JP2011093889A - Eye wash agent - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide (i) an eye wash agent exhibiting practically sufficient washing effect, (ii) an eye wash agent for cosmetic cleansing use sufficiently and effectively washing away and removing makeup from eyeballs or their surroundings and preventing reattachment of the cosmetics, and (iii) an eye wash agent for pollen washing use sufficiently and effectively washing away and removing the pollens from eyeballs or their surroundings and preventing reattachment of the pollens. <P>SOLUTION: There are provided (i) the eye wash agent including a carboxyvinyl polymer and a monoterpene, wherein the amount of the eye wash agent used each time is 500 μL or more; (ii) the eye wash agent for washing away makeup and comprising the carboxyvinyl polymer and the monoterpene; and (iii) the eye wash agent for washing away pollens and comprising the carboxyvinyl polymer and the monoterpene. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an eye wash, in particular, an eye wash for washing and removing cosmetics adhering to the eyeball and eyelid, and an eyewash for washing and removing pollen adhering to the eyeball and eyelid.

Eyewashes are used to prevent eye diseases by washing eyes and removing dust and sweat from the eyes.
For example, Patent Document 1 includes an ophthalmic agent containing a water-soluble polymer, ethanol, 0.005 to 0.040 w / v% menthol, and chlorobutanol, and having an absolute viscosity at 25 ° C. of 1.3 to 15 mPa · s. Is disclosed. Patent Document 1 describes a carboxyvinyl polymer as an example of a water-soluble polymer, and describes that this ophthalmic agent contains an eyewash.
Patent Document 2 discloses an ophthalmic composition containing a terpenoid, a water-soluble polymer compound, and a local anesthetic. In Patent Document 2, a carboxyvinyl polymer is described as an example of a water-soluble polymer, and an eye wash is described as one of the uses of an ophthalmic composition.
However, the eyewashes described in these documents cannot provide a practically sufficient eyewash effect.

JP 2006-176501 (Claim 1, paragraph 0014, paragraph 0022, etc.) JP 2003-183157 (Claim 1, paragraph 0012, paragraph 0028, etc.)

  An object of the present invention is to provide an eye wash that provides a practically sufficient cleaning effect. The present invention also provides an eyewash for cleaning cosmetics that can effectively cleanse and remove cosmetics from the eyeball or its surroundings, prevent re-adhesion to the eyeball or its surroundings, and sufficiently clean and remove the pollen. An object of the present invention is to provide an eyewash for pollen washing that can be effectively washed from its surroundings, and can be sufficiently washed and removed while preventing re-adhesion to the eyeball or its surroundings.

The present inventor repeated researches to solve the above problems, and obtained the following knowledge.
(i) An eye wash containing carboxyvinyl polymer and monoterpene effectively cleans the cosmetics adhering to the eyeball and its surroundings, and prevents re-adhesion to the eyeball (especially the cornea) and its surroundings. Can be washed and removed.
(ii) An eye wash containing carboxyvinyl polymer and monoterpene effectively cleans the pollen adhering to the eyeball and its surroundings, and prevents re-adhesion to the eyeball (especially the cornea) and its surroundings. Can be cleaned and removed.
(iii) Eyewashes containing carboxyvinyl polymer and monoterpene, particularly when the amount used (contact amount once) brought into contact with the site to be cleaned is 500 μl or more, such as cosmetics, pollen, dust, etc. The dirt can be washed effectively, and reattachment to the eyeball (especially the cornea) and its surroundings can be prevented, and it can be sufficiently washed and removed.
(iv) By using carboxyvinyl polymer and monoterpene in combination, a synergistic effect on the eye washing action is recognized as compared with the case where each component is used alone.
The present invention has been completed based on the above findings, and provides the following eye wash.

Item 1. An eye wash comprising a carboxyvinyl polymer and a monoterpene and having a use amount of 500 μl or more in contact with a site to be cleaned at a time.
Item 2. Item 2. The eyewash according to Item 1, wherein the content of the carboxyvinyl polymer is 0.001 to 10 w / v% with respect to the eyewash.
Item 3. Item 3. The eyewash according to Item 1 or 2, wherein the monoterpene content is 0.0001 to 0.2 w / v% with respect to the eyewash.
Item 4. Item 4. The eye wash according to any one of Items 1 to 3, wherein the monoterpene is at least one selected from the group consisting of menthol, borneol, geraniol, and bergamot oil.
Item 5. An eyewash for washing cosmetics comprising carboxyvinyl polymer and monoterpene.
Item 6. Item 6. The eyewash according to Item 5, wherein the content of the carboxyvinyl polymer is 0.001 to 10 w / v% with respect to the eyewash.
Item 7. Item 7. The eyewash according to Item 5 or 6, wherein the monoterpene content is 0.0001 to 0.2 w / v% with respect to the eyewash.
Item 8. Item 8. The eye wash according to any one of Items 5 to 7, wherein the monoterpene is at least one selected from the group consisting of menthol, borneol, geraniol, and bergamot oil.
Item 9. Item 9. The eye wash according to any one of Items 5 to 8, wherein the amount used to contact the site to be cleaned at a time is 500 μl or more.
Item 10. An eyewash for pollen cleaning comprising carboxyvinyl polymer and monoterpene.
Item 11. Item 11. The eyewash according to Item 10, wherein the content of the carboxyvinyl polymer is 0.001 to 10 w / v% with respect to the eyewash.
Item 12. Item 12. The eyewash according to Item 10 or 11, wherein the monoterpene content is 0.0001 to 0.2 w / v% with respect to the eyewash.
Item 13. Item 13. The eye wash according to any one of Items 10 to 12, wherein the monoterpene is at least one selected from the group consisting of menthol, borneol, geraniol, and bergamot oil.
Item 14. Item 14. The eyewash according to any one of Items 10 to 13, wherein the amount used to contact the site to be cleaned at a time is 500 μl or more.

The eye wash of the present invention effectively removes dirt such as pollen, dust and cosmetics (mascara, eyeliner, eye shadow, lotion, milky lotion, eye cream, etc.) adhering to the eyeball (particularly the cornea) Adhesion can be prevented and sufficient cleaning and removal can be performed.
Even if the stain is transferred from the eyeball into the eye wash, generally, the stain transferred to the eye wash tends to reattach to the eyeball or eyelid, but the eye wash of the present invention prevents such reattachment. , Dirt can be effectively removed.
In addition, there are cases where pollen is attached around the eyes or cosmetics such as mascara, eyeliner, and eye shadow are applied, and stains that have moved into the eyewash due to the use of the eyewash On the other hand, it may adhere to the eyeball, but if the eyewash is used with the eyewash of the present invention, adhesion of a large amount of cosmetics and the like transferred into the eyewash can also be suppressed.
Moreover, the eye wash of this invention is especially suitable for the washing | cleaning use of cosmetics, or the washing | cleaning use of pollen by including a carboxy vinyl polymer and a monoterpene.
In addition, the eyewash of the present invention includes a carboxyvinyl polymer and a monoterpene, so that a synergistic eyewash effect is recognized as compared with the case where each component is used alone.
Furthermore, the eye wash of the present invention is safe for the eyes.

It is a figure which shows the synergistic effect of a carboxy vinyl polymer and menthol about the washing | cleaning effect | action of the cosmetics from a rabbit corneal cell. It is a figure which shows the influence of the usage-amount of the eye wash which has on the washing | cleaning effect | action of the cosmetics from a rabbit corneal cell. It is a figure which shows the synergistic effect of a carboxy vinyl polymer and a menthol regarding the washing | cleaning effect | action of the pollen from a rabbit corneal cell.

Hereinafter, the present invention will be described in detail.
The eye wash of the present invention is an eye wash containing a carboxyvinyl polymer and a monoterpene and having a single use amount of 500 μl or more brought into contact with a site to be cleaned at a time. The part to be cleaned is a part selected from the eyes (eyeballs) and other parts around the eyeball.

Carboxyvinyl polymers carboxyvinyl polymers (Carboxyvinyl polymer:. To herein sometimes abbreviated as "CVP") is a hydrophilic polymer obtained by polymerizing acrylic acid as a main component, a polyacrylic acid, or Any of polyacrylates may be used.
Even when polyacrylic acid is used at the time of mixing each component, when the pH is adjusted, a part or all of the resulting composition may be a polyacrylate. Preferably, low-viscosity polyacrylic acid is used when mixing the carboxyvinyl polymer and the other components, and the viscosity of the eyewash composition is adjusted by adjusting the pH, optionally partially or entirely as a polyacrylate. May be raised. It is also preferable to use a polyacrylate from the time of mixing.
Polyacrylic acid salts include alkali metal salts such as polyacrylic acid sodium salt and potassium salt; polyacrylic acid monoethanolamine salt, diethanolamine salt, amine salt such as triethanolamine salt; polyacrylic acid ammonium salt Salt can be used. Of these, alkali metal salts are preferred.

Further, the polyacrylic acid or a salt thereof may be either a crosslinked type or a non-crosslinked type, but a crosslinked polymer is preferable in that the effect of the present invention is easily exhibited.
A carboxy vinyl polymer can use a commercial item. Commercially available products include Carbopol (trade name) (Noveon, Lubrizol), Shintalen (trade name), Hibiswako (trade name) (both Wako Pure Chemical Industries, Ltd.), Apec (trade name) (Sumitomo Seika) Junron (trade name) (Nippon Pure Chemicals) and the like can be used.
Carboxyvinyl polymers can be used alone or in combination of two or more.
The content ratio of the carboxyvinyl polymer is preferably about 0.001 to 10 (w / v)%, more preferably about 0.05 to 5 (w / v)%, more preferably 0.1 to Even more preferably about 1 (w / v)%. If it is the range of the said content ratio, sufficient washing | cleaning effect and reattachment inhibitory effect will be acquired. Moreover, if it is the range of the said content ratio, a favorable usability | use_condition will be obtained, an eyewash will not adhere easily to the periphery of an eyeball, and the irritation | stimulation feeling of a monoterpene can be suppressed effectively.

Monoterpenes Monoterpenes include monocyclic monoterpenes such as menthol, anethole, eugenol; bicyclic monoterpenes such as borneol, isoborneol, cineol, and pinene; geraniol, nerol, myrsenol, linalool, linalool acetate, and laban Examples include acyclic monoterpenes such as durol. The monoterpene may be any of d-form, l-form, or dl-form.
As a monoterpene, you may use the essential oil containing it. Such essential oils include peppermint oil, eucalyptus oil, peppermint oil, bergamot oil, spearmint oil, rose oil and the like.
Among them, menthol, borneol, geraniol, and bergamot oil are preferable, menthol, geraniol, and bergamot oil are more preferable, menthol is further preferable, and l-menthol is particularly preferable.
A monoterpene can use a commercial item. Examples of commercially available products include, for example, 1-menthol, dl-menthol, d-borneol, dl-borneol, geraniol, cineole, eucalyptus oil, bergamot oil, manufactured by Takasago Inc. Mentha oil and the like can be mentioned.

In addition, essential oils can be collected from plants by known methods. As such a known essential oil collection method, steam distillation method, oil adsorption method of extracting essential oil with ethanol after adding plant to deodorized animal oil and fat, extracting the essential oil with ethanol, organic plant such as hexane and benzene Examples of the extraction method include a solvent extraction method in which extraction is performed with a solvent or a supercritical fluid, the extraction solvent is dissolved in ethanol, and then the residue is collected by evaporation of ethanol. Monoterpenes can also be recovered from essential oils by various chromatographies.
A monoterpene can be used individually by 1 type or in mixture of 2 or more types.

The content ratio of the monoterpene is preferably about 0.0001 to 0.2 (w / v)%, more preferably about 0.001 to 0.15 (w / v)%, and more preferably 0.003 to 0.1 ( Even more preferred is about w / v)%.
In particular, a particularly preferable range as the content ratio of menthol is preferably about 0.0001 to 0.08 (w / v)% as a total amount of menthol, and about 0.001 to 0.05 (w / v)% with respect to the whole eye wash. More preferably, about 0.003-0.03 (w / v)% is still more preferable.
If it is the range of the said content ratio, sufficient washing | cleaning effect and reattachment inhibitory effect will be acquired. Moreover, if it is the range of the said content ratio, a favorable feeling of use will be obtained and sufficient refreshing feeling will be acquired by suppressing the unpleasant feeling of use by the other component contained in an eyewash.

Optional components In addition to the above-described components, the eye wash of the present invention may contain active ingredients (pharmacologically active ingredients, physiologically active ingredients, etc.) widely used in ophthalmic compositions. The type of such component is not particularly limited, and examples thereof include a decongestant component, an eye muscle modulator component, an anti-inflammatory component or an astringent component, an antihistamine component or an antiallergic component, vitamins, amino acids, antibacterial agents. Examples thereof include a drug component or a bactericidal component, a saccharide, a polymer compound or a derivative thereof, cellulose or a derivative thereof, a local anesthetic component, a glaucoma treatment component, a cataract treatment component, and the like. Examples of the pharmacologically active component and physiologically active component suitable in the present invention include the following components.

  Decongestant: For example, α-adrenergic agonists, specifically epinephrine, epinephrine hydrochloride, ephedrine hydrochloride, oxymetazoline hydrochloride, tetrahydrozoline hydrochloride, naphazoline hydrochloride, phenylephrine hydrochloride, methylephedrine hydrochloride, epinephrine hydrogen tartrate, naphazoline nitrate. These may be d-form, l-form or dl-form.

  Eye muscle modulator component: For example, cholinesterase inhibitor having an active center similar to acetylcholine, specifically, neostigmine methyl sulfate, tropicamide, atropine sulfate helenien, and the like.

  Anti-inflammatory component or astringent component: for example, zinc sulfate, zinc lactate, allantoin, epsilon-aminocaproic acid, indomethacin, lysozyme chloride, silver nitrate, pranoprofen, sodium azulenesulfonate, dipotassium glycyrrhizinate, diammonium glycyrrhizinate, Diclofenac sodium, bromfenac sodium, berberine chloride, berberine sulfate, etc.

  Antihistamine component or antiallergic agent component: for example, salt such as acitazanolast, diphenhydramine or its hydrochloride, salt such as chlorpheniramine maleate, ketotifen fumarate, levocabastine or its hydrochloride, amlexanox, ibudilast, tazanolast, Salts such as tranilast, oxatomide, suplatast or its tosylate, sodium cromoglycate, potassium pemirolast, etc.

  Vitamins: for example, retinol acetate, retinol palmitate, pyridoxine hydrochloride, flavin adenine dinucleotide sodium, pyridoxal phosphate, cyanocobalamin, panthenol, calcium pantothenate, sodium pantothenate, ascorbic acid, tocopherol acetate, tocopherol nicotinate, succinic acid Tocopherol, tocopherol calcium succinate, ubiquinone derivatives, etc.

  Amino acids: for example, aminoethyl sulfonic acid (taurine), glutamic acid, creatinine, sodium aspartate, potassium aspartate, magnesium aspartate, magnesium aspartate mixture, glutamic acid, sodium glutamate, magnesium glutamate, epsilon-aminocaproic acid, glycine , Alanine, arginine, lysine, γ-aminobutyric acid, γ-aminovaleric acid, sodium chondroitin sulfate and the like. These may be d-form, l-form or dl-form.

  Antibacterial component or bactericidal component: for example, alkylpolyaminoethylglycine, chloramphenicol, sulfamethoxazole, sulfisoxazole, sulfamethoxazole sodium, sulfisoxazole diethanolamine, sulfisoxa Zole monoethanolamine, sodium sulfisomezole, sodium sulfisomidine, ofloxacin, norfloxacin, levofloxacin, lomefloxacin hydrochloride, acyclovir and the like.

  Sugars: For example, monosaccharides, disaccharides, specifically glucose, maltose, trehalose, sucrose, cyclodextrin, xylitol, sorbitol, mannitol and the like.

  High molecular compound or derivative thereof: for example, alginic acid, sodium alginate, dextrin, dextran, pectin, hyaluronic acid, chondroitin sulfate, polyvinyl alcohol (completely or partially saponified product), polyvinylpyrrolidone, macrogol and pharmaceutically acceptable salts thereof Such.

  Cellulose or derivatives thereof: for example, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, methyl cellulose, carboxymethyl cellulose, carboxymethyl cellulose sodium, carboxyethyl cellulose, nitrocellulose and the like.

  Local anesthetic components: for example, chlorobutanol, procaine hydrochloride, lidocaine hydrochloride, etc.

  The blending ratio of various components is known in the field of eyewash, and the blending ratio of the above components of the eyewash of the present invention is appropriately set according to the type of pharmacologically active ingredient or physiologically active ingredient. For example, the blending ratio of the pharmacologically active ingredient or the physiologically active ingredient can be selected from the range of about 0.0001 to 30% by weight, preferably about 0.001 to 10% by weight, based on the total amount of the eyewash.

  In addition, in the eyewash of the present invention, various components and additives are appropriately selected according to conventional methods according to the use and form as long as the effects of the invention are not impaired, and one or more are used in combination. Can be contained. As those components or additives, for example, carriers (aqueous solvent, aqueous or oily base, etc.) commonly used in the preparation of solutions, surfactants, preservatives, bactericides or antibacterial agents, pH adjusters, Various additives such as an isotonizing agent, a chelating agent, a buffering agent and a stabilizing agent can be mentioned.

Although the typical component used for the eyewash of this invention is illustrated below, it is not limited to these.
Carrier: An aqueous solvent such as water or hydrous ethanol.

  Surfactant: For example, polyoxyethylene (hereinafter abbreviated as POE) -polyoxypropylene (hereinafter abbreviated as POP) block copolymer (specifically, poloxamer 407, etc.), ethylenediamine POE-POP block copolymer adduct ( Specifically, such as poloxamine), POE sorbitan fatty acid ester (specifically, polysorbate 80), POE hydrogenated castor oil (specifically, POE (60) hydrogenated castor oil), non-oxygen such as polyoxyl stearate Ionic surfactants; glycine-type amphoteric surfactants such as alkyldiaminoethylglycine; cationic surfactants such as alkyl quaternary ammonium salts (specifically, benzalkonium chloride, benzethonium chloride, etc.). The numbers in parentheses indicate the number of added moles.

  Perfume or refreshing agent: for example, essential oils (eg fennel oil, cinnamon oil).

  Preservatives, bactericides or antibacterials: for example, polydronium chloride, alkyldiaminoethylglycine hydrochloride, sodium benzoate, ethanol, benzalkonium chloride, benzethonium chloride, chlorhexidine gluconate, chlorobutanol, sorbic acid, potassium sorbate, dehydroacetic acid Sodium, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate, oxyquinoline sulfate, phenethyl alcohol, benzyl alcohol, biguanide compounds (specifically, polyhexamethylene biguanide or its hydrochloride) , Glow Kill (trade name, manufactured by Rhodia).

  pH adjuster: For example, hydrochloric acid, sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, triethanolamine, monoethanolamine, diisopropanolamine, sulfuric acid, phosphoric acid and the like.

  Isotonizing agents: for example, sodium bisulfite, sodium sulfite, potassium chloride, calcium chloride, sodium chloride, magnesium chloride, potassium acetate, sodium acetate, sodium bicarbonate, sodium carbonate, sodium thiosulfate, magnesium sulfate, dihydrogen phosphate Sodium, sodium dihydrogen phosphate, potassium dihydrogen phosphate, glycerin, propylene glycol and the like.

  Chelating agent: for example, ascorbic acid, tetrasodium edetate, sodium edetate, citric acid and the like.

  Buffer: citrate buffer, acetate buffer, carbonate buffer, borate buffer, phosphate buffer, etc. Specifically, citric acid, sodium citrate, acetic acid, potassium acetate, sodium acetate, sodium bicarbonate, sodium carbonate, boric acid, borax, phosphoric acid, disodium hydrogen phosphate, sodium dihydrogen phosphate, phosphoric acid Such as potassium dihydrogen.

  Stabilizers: dibutylhydroxytoluene, trometamol, sodium formaldehyde sulfoxylate (Longalite), tocopherol, sodium pyrosulfite, monoethanolamine, aluminum monostearate, glyceryl monostearate, etc.

  An arbitrary component can be used individually by 1 type or in combination of 2 or more types.

In addition , the dosage form of the eye wash of the present invention is not particularly limited, and examples of the dosage form include solutions, suspensions, and emulsions. In these cases, the water content is usually about 90% by weight or more, preferably about 95% by weight or more. A liquid agent is preferable.
Further, the pH of the eye wash of the present invention may be about 3 to 9, preferably about 5 to 8.5, more preferably about 5.5 to 8.
Further, the osmotic pressure ratio of the eye wash of the present invention may be about 0.6 to 1.6, preferably about 0.7 to 1.5, more preferably about 0.8 to 1.4, particularly preferably. Is in the range of about 0.8 to 1.2. The osmotic pressure ratio is the ratio of the osmotic pressure of the sample to the osmotic pressure (286 mOsm) of the 0.9 w / v% sodium chloride aqueous solution based on the 15th revised Japanese pharmacopoeia. Measure by referring to the freezing point method. As the standard solution for osmotic pressure ratio measurement, a commercially available standard solution for osmotic pressure ratio measurement (0.9 w / v% sodium chloride aqueous solution) or the like can be used.

Further, the viscosity of the eye wash of the present invention may be about 2 to 1100 mPa · s, preferably about 4 to 400 mPa · s, and more preferably about 10 to 100 mPa · s. The viscosity is measured according to the viscosity measurement method described in the 15th revised Japanese Pharmacopoeia General Test Method, and (3) a cone-plate rotational viscometer (cone plate viscometer). Specifically, TV-20 (Toki Sangyo) can be used as a cone plate viscometer. Selection of conditions such as rotor and rotational speed is based on the machine's instruction manual and the viscosity at 25 ° C is measured.
The material of the container for storing the eyewash of the present invention is not particularly limited, and examples thereof include polyethylene terephthalate, polyethylene naphthalate, polyarylate, polycarbonate, polyethylene, polypropylene, and the like, particularly polyethylene terephthalate and / or polyethylene. A container containing naphthalate is preferred. Further, the eye wash of the present invention is preferably filled in a light-shielded container, and may be shielded from light by mixing a colorant or the like with the container material described above, or covered with a shrink film, an outer box, or the like. May be shielded from light. By putting it in a light shielding container, the eye wash of the present invention can be kept stable for a long period of time.

Production Method The eye wash of the present invention can be prepared by a conventional method. For example, after dispersing each component (carboxyvinyl polymer, monoterpene, and other pharmacologically active components, physiologically active components, additives, etc., which may be optionally added) in a carrier such as water, a homogenizer or the like is used. What is necessary is just to prepare by making it uniform, melt | dissolve or emulsify, and adjusting pH with a pH adjuster. In addition, as a method for sterilizing the preparation, methods such as autoclave sterilization and filter sterilization are selected.

Method of use The eye wash of the present invention has a use amount (meaning a single use amount used for washing one eye) of contact with the site to be cleaned at a time, usually 500 μL or more, preferably about 1 mL to 10 mL. More preferably, it is about 2 mL to 8 mL, particularly preferably about 3 to 7 mL. If it is in the above range, the effects of the present invention will be sufficiently exerted, such as sufficiently removing dirt adhered to the eyeball and eyelid and preventing reattachment to the eyeball (cornea, conjunctiva, ocular mucosa) and its surroundings. can do. In addition, if the amount is extremely large, the cleaning effect may be reduced, but if it is within the above range, a practically sufficient cleaning effect can be obtained.
Washing may be performed by bringing a single use amount of an eyewash into contact with the eye and its surroundings (eyelid etc.) at once. Specifically, for example, a single use amount of an eye wash is placed in a cup-shaped container, the end of the cup is pressed around the eye, and the single use amount is applied to the eyes and the surroundings (eyelids, etc.). What is necessary is just to carry out by making eyewash contact at a time. In this case, it is preferable to wash the eyewash in the cup with stirring by pressing the cup using a flexible cup. Even if it is used by such a method, the dirt once removed by the eyewash of this application is hard to reattach.
The cleaning may be performed when necessary, and the number of cleanings per day is not particularly limited, but is preferably about 3 to 6 times per day.
Moreover, the human subject to be used is not particularly limited. In addition to healthy people, it can also be used for patients with dry eye, eye strain, and other eye diseases.

Use The washing object of the eye wash of the present invention is not particularly limited, and can be used to remove all stains attached to the eyeball and its surroundings. In particular, it is suitable as an eye wash for washing cosmetics, that is, for removing makeup stains, or an eye wash for pollen washing. When it is used for cosmetic cleaning or pollen cleaning, the amount used once is not particularly limited, but is preferably 500 μL or more. The amount used once is more preferably about 1 mL to 10 mL, still more preferably about 2 mL to 8 mL, and particularly preferably about 3 to 7 mL.

EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited to these.
Test 1 (Synergistic effect of carboxyvinyl polymer and monoterpene)
(1) Method
(1) Rabbit corneal cell line (SIRC) was inoculated on a culture plate (24 well, Nippon Corning) and cultured under conditions of 37 ° C., 5% CO ₂ and humidity of 90% until it became confluent. The growth medium used was Medium 199 (Nippon Invitrogen) with fetal bovine serum added to 10 v / v% of the total amount of Medium 199. The bottom area of this culture plate is close to the surface area of one eyeball.
(2) After aspirating and removing the growth medium in each well, mascara product 1 (Shiseido; Maquillage full vision mascara) (Note 1), mascara product 2 (Shiseido; Majorica Majorca mascara) (Note 2), or mascara product 3 (NEL, Inc .; Maybelline Volume Express Magnum Mascara) (Note 3) is dispersed in 1 w / v% Tween20 aqueous solution for 30 minutes, and then the concentration of mascara is adjusted to 0.1 w / v% in the HBSS buffer. 500 μL of the lysed product was added and incubated at 37 ° C. under 5% CO ₂ for 5 minutes to adsorb the mascara to the cells.
(3) After removing the supernatant from each well by suction, 500 μL of each test solution shown in Tables 1 to 6 below was added to each well and shaken for 30 seconds at a speed of 400 rpm.
(4) After each test solution in each well was removed by suction, a 5-point photomicrograph was arbitrarily taken from each well, and the total area of the remaining mascara was calculated with image analysis software (WinROOF).

(Note 1) Ingredients: hydrogenated polyisobutene, cyclomethicone, dextrin palmitate, trimethylsiloxysilicic acid, polymethylsilsesquioxane, distedimonium hectorite, microcrystalline wax, sucrose acetate stearate, PEG-10 dimethicone, BG, tri (trimethylsiloxy) silylpropylcarbamic acid pullulan, water, polyethylene, nylon-12, sucrose tetraisostearate, arginine, PEG-20 hydrogenated castor oil triisostearate, triethoxycaprylylsilane, silica, tocopherol, BHT , Iron oxide, mica (note 2) ingredients: hydrogenated polyisobutene, cyclomethicone, dextrin palmitate, sucrose acetate stearate, distedimonium hectorite, tri (trime Lucyloxy) silylpropylcarbamic acid pullulan, candelilla wax, PEG-10 dimethicone, nylon-6, BG, water, triisostearic acid PEG-20 hydrogenated castor oil, tocopherol acetate, macadamia nut oil, triethoxycaprylylsilane, silica, Sucrose tetraisostearate, paraffin, microcrystalline wax, tocopherol, BHT, iron oxide, carbon black (Note 3) Ingredients: isododecane, beeswax, carnauba wax, disteardimonium hectorite, water, (allyl stearate / VA) copolymer, Rice bran wax, paraffin, modified alcohol, poly (vinyl laurate), (VP / eicosene) copolymer, propylene carbonate, talc, (ethylene diamine / dimer dilinoleate stearyl) copolymer, PEG-30 glyceryl stearate Ru, propylparaben, methylparaben, hydrogenated jojoba oil, water-soluble collagen, [+/-] iron oxide, gunjou, titanium oxide, mica, chromium oxide, chromium hydroxide, manganese violet, conjugate, silica

In the test using each test solution shown in Table 1 below, the above operations (1) to (4) were repeated three times.
The washing rate was calculated from the total area of the remaining mascara measured for each test solution according to the following formula. In the experiment using each test solution shown in Table 1 below, the cleaning rate was calculated using the average value of the total area of the remaining mascara.

Cleaning rate (%)
= (1-Total area of remaining mascara in Examples or Comparative Examples /
Control remaining mascara total area) x 100

(2) Results
(2-1) Menthol / Mascara product 1 / CVP product 1
The composition of each test solution is shown in Table 1 below. The mascara used was Shiseido's Maquillage full vision mascara.
For menthol, 1-menthol manufactured by Nagaoka Jitsugyo Co., Ltd. was used. As the carboxyvinyl polymer, AQUPEC HV-505E (cross-linked type) manufactured by Sumitomo Seika Co., Ltd. was used. As the PBS buffer, D-PBS (code: 16220015) manufactured by Kojin Bio Inc. was used. The general composition of D-PBS is 0.2 g / L potassium chloride, 0.2 g / L potassium dihydrogen phosphate, 8 g / L sodium chloride, 1.15 g / L disodium monohydrogen phosphate (anhydride).

The results are shown in FIG. As is clear from FIG. 1, the mascara washing rate was markedly higher by using both menthol and carboxyvinyl polymer in combination than when both were used alone. By using both in combination, it can be seen that the cosmetic was sufficiently washed, the reattachment to the cornea was effectively prevented, and a synergistic effect was observed in the washing action.
(2-2) Bergamot oil, mascara product 1 and CVP product 1
The composition of each test solution and the washing rate are shown in Table 2 below. The mascara used was Shiseido's Maquillage full vision mascara.
As the bergamot oil, bergamot oil manufactured by Takasago International Corporation was used. As the carboxyvinyl polymer, AQUPEC HV-505E (cross-linked type) manufactured by Sumitomo Seika Co., Ltd. was used. As the PBS buffer, D-PBS (code: 16220015) manufactured by Kojin Bio Inc. was used.
From Table 2, it can be seen that even when bergamot oil and carboxyvinyl polymer are used in combination, an excellent cleaning effect and anti-reattachment effect can be obtained for cosmetics attached to corneal cells.
(2-3) Bergamot oil or geraniol mascara product 2 CVP product 1
The composition of each test solution and the washing rate are shown in Table 3 below. For mascara, we used Majolica Majorca mascara from Shiseido.
As the bergamot oil, bergamot oil manufactured by Takasago International Corporation was used. As geraniol, geraniol pure manufactured by Takasago International Corporation was used. As the carboxyvinyl polymer, AQUPEC HV-505E (cross-linked type) manufactured by Sumitomo Seika Co., Ltd. was used. As the PBS buffer, D-PBS (code: 16220015) manufactured by Kojin Bio Inc. was used.
From Table 3, it can be seen that even when bergamot oil or geraniol and a carboxyvinyl polymer are used in combination, an excellent cleaning effect and reattachment suppressing effect can be obtained for cosmetics attached to corneal cells. Moreover, it was confirmed that the eye wash of this invention has the outstanding washing | cleaning effect | action and the reattachment inhibitory effect irrespective of the kind of mascara cosmetics.
(2-4) Menthol / Mascara product 1 / CVP product 2
The composition of each test solution and the cleaning rate are shown in Table 4 below. The mascara used was Shiseido's Maquillage full vision mascara.
For menthol, 1-menthol manufactured by Nagaoka Jitsugyo Co., Ltd. was used. As the carboxyvinyl polymer, Carbopol 981 (cross-linked type) manufactured by Lubrizol was used. As the PBS buffer, D-PBS (code: 16220015) manufactured by Kojin Bio Inc. was used.
Table 4 shows that the eye wash of this invention has the outstanding washing | cleaning effect | action and reattachment inhibitory effect with respect to the cosmetics adhering to the corneal cell irrespective of the kind of carboxyvinyl polymer.
(2-5) Bergamot oil or Geraniol / Mascara product 1 / CVP product 2
The composition of each test solution and the washing rate are shown in Table 5 below. The mascara used was Shiseido's Maquillage full vision mascara.
As the bergamot oil, bergamot oil manufactured by Takasago International Corporation was used. As geraniol, geraniol pure manufactured by Takasago International Inc. was used. As the carboxyvinyl polymer, Carbopol 981 (cross-linked type) manufactured by Lubrizol was used. As the PBS buffer, D-PBS (code: 16220015) manufactured by Kojin Bio Inc. was used.
Table 5 shows that the eye wash of this invention has the outstanding washing | cleaning effect | action and reattachment inhibitory effect with respect to the cosmetics adhering to the corneal cell irrespective of the kind of carboxyvinyl polymer.
(2-6) Menthol / Mascara products 3 / CVP products 1 or 2
The composition of each test solution and the cleaning rate are shown in Table 6 below. The mascara used was a Maybelline Volume Express Magnum mascara manufactured by NLO.
For menthol, 1-menthol manufactured by Nagaoka Jitsugyo Co., Ltd. was used. As the carboxyvinyl polymer ¹⁾ , AQUPEC HV-505E (cross-linked type) manufactured by Sumitomo Seika Co., Ltd. was used. As the carboxyvinyl polymer ²⁾ , Carbopol 981 (cross-linked type) manufactured by Lubrizol was used. As the PBS buffer, D-PBS (code: 16220015) manufactured by Kojin Bio Inc. was used.
From Table 6, it can be seen that the eye wash of the present invention has an excellent cleaning action and anti-reattachment action on cosmetics attached to corneal cells, regardless of the type of mascara or the type of carboxyvinyl polymer. .

Test 2 (Evaluation of usage)
(1) Rabbit corneal cell line (SIRC) was inoculated on a culture plate (12 well, Nippon Corning), and cultured under conditions of 37 ° C., 5% CO ₂ and 90% humidity until it became confluent. The growth medium used was Medium 199 (Nippon Invitrogen) with fetal bovine serum added to 10 v / v% of the total amount of Medium 199.
(2) After the growth medium in each well is removed by suction, mascara (Shiseido, Maquillage full vision mascara is dispersed in 1 w / v% Tween20 aqueous solution for 30 minutes, and then the mascara concentration becomes 0.1 w / v%. 500 μL of the solution dissolved in HBSS buffer was added and incubated at 37 ° C. under 5% CO ₂ for 5 minutes to adsorb the mascara to the cells.
(3) After removing the supernatant from each well by suction, add 100 μL, 500 μL, and 5 mL of Example Formula 1 shown in Table 1 to each well, and shake for 30 seconds at a speed of 400 rpm. (Test solution)
As a control, 500 μL of the test solution of Comparative Formulation Example 1 in Table 1 was added to 1 well and shaken for 30 seconds at a speed of 400 rpm.
(4) After each test solution in each well was removed by suction, a 5-point photomicrograph was arbitrarily taken from each well, and the total area of the remaining mascara was calculated with image analysis software (WinROOF).

The above operations (1) to (4) were repeated three times.
From the average value of the total area of the remaining mascara measured for each test solution (Example Formula 1 (100 μL, 500 μL, 5 mL), Comparative Example Formula 1 (500 μL)), the washing rate for the test solution was calculated according to the following formula. Furthermore, from the cleaning rate, a ratio (cleaning degree) with respect to the cleaning rate when 500 μL of Example Formulation 1 was used was calculated.

Cleaning rate (%) =
(1- remaining mascara total area / Example formulation 1 (100 μL, 500 μL, 5 mL) /
Comparative Example Formula 1 (500 μL) remaining mascara total area) × 100

Degree of cleaning = (Cleaning rate of Example formulation 1 (100 μL, 500 μL, 5 mL) /
Example prescription 1 (500 μL) cleaning rate) × 100

  The results are shown in FIG. As is clear from FIG. 2, the agent of Example Formula 1 of the present invention showed a high cleaning effect at both usage amounts of 500 μL and 5 mL.

Test 3 (Evaluation of effect on pollen)
(1) Rabbit corneal cell line (SIRC) was inoculated on a culture plate (24 well, Nippon Corning) and cultured under conditions of 37 ° C., 5% CO ₂ and humidity of 90% until it became confluent. The growth medium used was Medium 199 (Nippon Invitrogen) with fetal bovine serum added to 10 v / v% of the total amount of Medium 199.
(2) After removing the growth medium in each well by suction, add 500 μL of HBSS buffer in which mugwort pollen (SIGMA, Cat.P9395-1G) is dispersed to 2 mg / ml, and add it at 37 ° C under 5% CO ₂ . Incubation for 5 minutes allowed the pollen to adsorb to the cells.
(3) After removing the supernatant from each well by suction, 500 μL of each test solution shown in Table 1 above was added to each well and shaken for 30 seconds at a speed of 400 rpm.
(4) After each test solution in each well was removed by suction, a 5-point photomicrograph was arbitrarily taken from each well, and the total area of residual pollen was calculated with image analysis software (WinROOF).

The above operations (1) to (4) were repeated three times.
From the average value of the total area of the remaining pollen measured for each test liquid (Example Formulation 1, Comparative Example Formulation 1, Comparative Example Formulation 2, Control Formulation), according to the following formula, Example Formulation 1 and Comparative Example Formulations 1 and 2 The washing rate was calculated.

Cleaning rate (%)
= 100-100 × (total residual pollen area of Example or Comparative Example / total residual pollen area of control)

  The results are shown in FIG. In the case of using menthol alone, the pollen cleaning effect was worse than the control using only PBS buffer, but by using menthol together with carboxyvinyl polymer, a higher pollen cleaning effect was obtained than in the case of using carboxyvinyl polymer alone. From this, it can be seen that a synergistic effect was also observed in pollen washing by the combined use of menthol and carboxyvinyl polymer.

  Formulation examples of the eye wash of the present invention are shown in Tables 7 to 10 below. AQUPEC HV-505E was used as carbomer 940, which is a carboxyvinyl polymer in each table, AQUPEC HV-504E (2984) was used as carbomer 934, and Carbopol 981NF was used as carbomer 941.

  The eye wash of the present invention can be suitably used for makeup stain removal, pollen cleaning and the like.

Claims (10)

  An eye wash comprising a carboxyvinyl polymer and a monoterpene and having a use amount of 500 μl or more in contact with a site to be cleaned at a time.   The eyewash according to claim 1, wherein the content of the carboxyvinyl polymer is 0.001 to 10 w / v% with respect to the eyewash.   The eye wash according to claim 1 or 2, wherein the monoterpene content is 0.0001 to 0.2 w / v% with respect to the eye wash.   The eye wash according to any one of claims 1 to 3, wherein the monoterpene is at least one selected from the group consisting of menthol, borneol, geraniol, and bergamot oil.   An eyewash for washing cosmetics comprising carboxyvinyl polymer and monoterpene.   An eyewash for pollen cleaning comprising carboxyvinyl polymer and monoterpene.   The eye wash according to claim 5 or 6, wherein the content of the carboxyvinyl polymer is 0.001 to 10 w / v% with respect to the eye wash.   The eye wash according to any one of claims 5 to 7, wherein the monoterpene content is 0.0001 to 0.2 w / v% with respect to the eye wash.   The eye wash according to any one of claims 5 to 8, wherein the monoterpene is at least one selected from the group consisting of menthol, borneol, geraniol, and bergamot oil.   The eye wash according to any one of claims 5 to 9, wherein the amount used to contact the site to be cleaned at a time is 500 µl or more.