JP2011068660A5 - - Google Patents
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- Publication number
- JP2011068660A5 JP2011068660A5 JP2010261850A JP2010261850A JP2011068660A5 JP 2011068660 A5 JP2011068660 A5 JP 2011068660A5 JP 2010261850 A JP2010261850 A JP 2010261850A JP 2010261850 A JP2010261850 A JP 2010261850A JP 2011068660 A5 JP2011068660 A5 JP 2011068660A5
- Authority
- JP
- Japan
- Prior art keywords
- pancreatic
- cells
- composition
- cell
- pdx
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 101000612089 Homo sapiens Pancreas/duodenum homeobox protein 1 Proteins 0.000 claims 6
- 102100041030 Pancreas/duodenum homeobox protein 1 Human genes 0.000 claims 6
- 210000004027 cell Anatomy 0.000 claims 5
- 238000000034 method Methods 0.000 claims 5
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims 4
- 210000001705 ectoderm cell Anatomy 0.000 claims 4
- 210000004039 endoderm cell Anatomy 0.000 claims 4
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 4
- 210000001704 mesoblast Anatomy 0.000 claims 4
- 102000051325 Glucagon Human genes 0.000 claims 2
- 108060003199 Glucagon Proteins 0.000 claims 2
- 102000004877 Insulin Human genes 0.000 claims 2
- 108090001061 Insulin Proteins 0.000 claims 2
- 102000005157 Somatostatin Human genes 0.000 claims 2
- 108010056088 Somatostatin Proteins 0.000 claims 2
- 210000002798 bone marrow cell Anatomy 0.000 claims 2
- 230000014509 gene expression Effects 0.000 claims 2
- MASNOZXLGMXCHN-ZLPAWPGGSA-N glucagon Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(C)C)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC=1C=CC=CC=1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC=1NC=NC=1)[C@@H](C)O)[C@@H](C)O)C1=CC=CC=C1 MASNOZXLGMXCHN-ZLPAWPGGSA-N 0.000 claims 2
- 229960004666 glucagon Drugs 0.000 claims 2
- 210000003494 hepatocyte Anatomy 0.000 claims 2
- 230000001939 inductive effect Effects 0.000 claims 2
- 229940125396 insulin Drugs 0.000 claims 2
- 229960003966 nicotinamide Drugs 0.000 claims 2
- 235000005152 nicotinamide Nutrition 0.000 claims 2
- 239000011570 nicotinamide Substances 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 210000004927 skin cell Anatomy 0.000 claims 2
- NHXLMOGPVYXJNR-ATOGVRKGSA-N somatostatin Chemical compound C([C@H]1C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CSSC[C@@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C=CC=CC=2)C(=O)N[C@@H](CC=2C3=CC=CC=C3NC=2)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1)[C@@H](C)O)NC(=O)CNC(=O)[C@H](C)N)C(O)=O)=O)[C@H](O)C)C1=CC=CC=C1 NHXLMOGPVYXJNR-ATOGVRKGSA-N 0.000 claims 2
- 229960000553 somatostatin Drugs 0.000 claims 2
- VBEQCZHXXJYVRD-GACYYNSASA-N uroanthelone Chemical compound C([C@@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(O)=O)C(C)C)[C@@H](C)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@@H](NC(=O)[C@H](CC=1NC=NC=1)NC(=O)[C@H](CCSC)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)CNC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H]1N(CCC1)C(=O)[C@H](CS)NC(=O)CNC(=O)[C@H]1N(CCC1)C(=O)[C@H](CC=1C=CC(O)=CC=1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)CC)C1=CC=C(O)C=C1 VBEQCZHXXJYVRD-GACYYNSASA-N 0.000 claims 2
- 208000016222 Pancreatic disease Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 208000024691 pancreas disease Diseases 0.000 claims 1
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US46971503P | 2003-05-12 | 2003-05-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006506631A Division JP2006525994A (ja) | 2003-05-12 | 2004-05-12 | 非膵島組織における調節された膵ホルモンの産生を誘導する方法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011068660A JP2011068660A (ja) | 2011-04-07 |
| JP2011068660A5 true JP2011068660A5 (de) | 2011-10-06 |
Family
ID=33435254
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006506631A Pending JP2006525994A (ja) | 2003-05-12 | 2004-05-12 | 非膵島組織における調節された膵ホルモンの産生を誘導する方法 |
| JP2010261850A Pending JP2011068660A (ja) | 2003-05-12 | 2010-11-24 | 非膵島組織における調節された膵ホルモンの産生を誘導する方法 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006506631A Pending JP2006525994A (ja) | 2003-05-12 | 2004-05-12 | 非膵島組織における調節された膵ホルモンの産生を誘導する方法 |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1624898A1 (de) |
| JP (2) | JP2006525994A (de) |
| AU (1) | AU2004236573B2 (de) |
| WO (1) | WO2004098646A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8778899B2 (en) | 1999-06-01 | 2014-07-15 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| US6774120B1 (en) | 1999-06-01 | 2004-08-10 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| EP1969118B2 (de) | 2005-12-21 | 2014-09-10 | Université Catholique De Louvain | Isolierte leberstammzellen |
| AU2007299649B2 (en) * | 2006-09-22 | 2012-11-15 | Baylor Research Institute | In vivo transformation of pancreatic acinar cells into insulin-producing cells |
| US20160067212A1 (en) * | 2013-03-15 | 2016-03-10 | Universite De Geneve | Use of insulin signaling antagonists, optionally in combination of transfection of non-beta cells, for inducing insulin production |
| MX2015017235A (es) | 2013-06-13 | 2017-05-04 | Orgenesis Ltd | Poblaciones celulares, metodos de transdiferenciacion y metodos de uso de los mismos. |
| EP3016665B1 (de) | 2013-07-05 | 2019-09-18 | Université Catholique de Louvain | Konditioniertes medium aus menschlichen adulten leberstammzellen und verwendung davon bei der behandlung von lebererkrankungen |
| MA41296A (fr) | 2014-12-30 | 2017-11-07 | Orgenesis Ltd | Procédés de transdifférenciation et procédés d'utilisation de ceux-ci |
| US9957287B2 (en) | 2016-05-26 | 2018-05-01 | Cornell University | Methods and compositions to treat type-1 and type-2 diabetes |
| EP3503909A4 (de) * | 2016-08-29 | 2020-04-01 | Hackensack University Medical Center | Zusammensetzungen und verfahren zur umprogrammierung adulter zellen durch die stammzelleigenschaften einer plättchenreichen fraktion von blut mit plättchenartigen zellen beim menschen |
| US10729730B2 (en) | 2016-08-29 | 2020-08-04 | Hackensack University Medical Center | Compositions and methods for reprogramming adult cells through the stemness of a platelet rich fraction of blood containing platelet-like cells in humans |
| EP3635106A4 (de) | 2017-05-08 | 2021-01-06 | Orgenesis Ltd. | Transdifferenzierte zellpopulationen und verfahren zur verwendung davon |
| US11788062B2 (en) * | 2017-07-27 | 2023-10-17 | Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College | Functional feline pancreatic cells from adipose tissue |
| CN112899351B (zh) * | 2021-02-03 | 2022-08-26 | 东华大学 | 一种双重荧光定量pcr检测pdx模型小鼠细胞浸润状态试剂盒 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6774120B1 (en) * | 1999-06-01 | 2004-08-10 | Sarah Ferber | Methods of inducing regulated pancreatic hormone production in non-pancreatic islet tissues |
| US20030138951A1 (en) * | 2001-10-18 | 2003-07-24 | Li Yin | Conversion of liver stem and progenitor cells to pancreatic functional cells |
| GB0206357D0 (en) * | 2002-03-18 | 2002-05-01 | Univ Bath | Cells |
| JP4136434B2 (ja) * | 2002-04-17 | 2008-08-20 | 進 清野 | インスリン産生細胞の誘導 |
-
2004
- 2004-05-12 EP EP04732369A patent/EP1624898A1/de not_active Ceased
- 2004-05-12 JP JP2006506631A patent/JP2006525994A/ja active Pending
- 2004-05-12 WO PCT/IB2004/001973 patent/WO2004098646A1/en active Application Filing
- 2004-05-12 AU AU2004236573A patent/AU2004236573B2/en not_active Expired
-
2010
- 2010-11-24 JP JP2010261850A patent/JP2011068660A/ja active Pending
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