JP2010265214A - Keratolytic detergent composition and keratolytic detergent - Google Patents

Abstract

A keratolytic detergent composition having high safety and keratolytic effect, and a keratolytic detergent.
A hydroxyalkyl ether carboxylic acid type anionic surfactant and an alkylamine oxide type semipolar surfactant are contained in the composition in a weight ratio of 60:40 to 10:90. Let
[Selection figure] None

Description

  The present invention relates to a keratolytic detergent composition capable of dissolving keratin and a keratolytic detergent.

  As one method for removing aging keratin, a method in which a strongly acidic or strongly alkaline chemical agent is applied to the skin and the keratin is dissolved, that is, a chemical peeling method is known. Such a chemical peeling method is a method for regaining healthy and beautiful skin by chemically dissolving the keratin with a strong acid or strong alkaline agent to promote the regeneration of new skin. There was a risk of damaging eyes, mucous membranes, etc.

  For this reason, the development of a keratolytic agent having high safety, that is, weak irritation to the skin, has been promoted (for example, Patent Documents 1 and 2).

JP 2000-186036 A JP 2007-269669 A

  However, in the chemical peeling method using the chemical peeling agent described in Patent Document 1, the first agent containing the chemical peeling agent is applied to the skin, and before or after that, the second agent containing L-ascorbic acid is 1 It was carried out by applying once or a plurality of times, that is, it was carried out using two drugs, and lacked convenience. In addition, it is required to be carried out by a specialist doctor and cannot be used safely by general consumers.

  In addition, the oil-in-water type keratolytic cosmetic described in Patent Document 2 has little irritation to the skin and can be safely used by general consumers, but does not provide a sufficient keratolytic effect.

  This invention is made | formed in view of such a condition, Comprising: It aims at providing the keratolytic detergent composition which has high safety | security and a keratolytic effect, and a keratolytic detergent.

  As a result of intensive studies on the above problems, the present inventors have found that a composition containing a hydroxyalkyl ether carboxylic acid type anionic surfactant and an alkylamine oxide type semipolar surfactant is safe. And it was found to be excellent in keratin solubility.

  That is, the keratolytic detergent composition according to the present invention has the following general formula (1):

(Wherein R ₁ represents an alkyl group or alkenyl group having 6 to 20 carbon atoms, and X represents hydrogen, an inorganic cation, or an organic cation.) An anionic surfactant of the hydroxyalkyl ether carboxylic acid type And the following general formula (2)

(In the formula, R ₂ represents an alkyl group having 8 to 22 carbon atoms, an alkenyl group or a polyoxyethylene alkyl ether group, and R ₃ and R ₄ represent an alkyl group having 1 to ₄ carbon atoms, an alkoxy group, and a hydroxyalkyl group. The alkylamine oxide type semipolar surfactant represented by the formula (1), wherein the weight ratio of the anionic surfactant to the semipolar surfactant is 60: 40-10. : 90.

  In addition, the keratolytic detergent composition according to the present invention may contain a bactericidal component. The bactericidal component contained in this case may be one or more selected from benzalkonium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, chlorhexidine, trichlorocarbanilide, triclosan, pyrithione zinc, and hinokitiol.

  Further, the keratolytic detergent composition according to the present invention may contain a moisturizing component.

  In addition, the keratolytic detergent composition according to the present invention may contain an anti-skin component.

  In addition, the keratolytic detergent composition according to the present invention may contain a scrub agent.

  Further, the keratolytic detergent according to the present invention is a keratolytic detergent configured by filling a container with a keratolytic detergent composition, and the keratolytic detergent composition is used as the keratolytic detergent composition. It may be filled with a cleaning composition.

  Alternatively, the keratolytic detergent according to the present invention is a keratolytic detergent configured by filling a pump former container with a keratolytic detergent composition. The keratolytic detergent composition may be filled.

  According to the present invention, it is possible to provide a keratolytic detergent composition excellent in safety and keratolysis, and a keratolytic detergent.

  Hereinafter, the present invention will be described in detail.

<Surfactant>
The keratolytic detergent composition of the present invention contains a hydroxyalkyl ether carboxylic acid type anionic surfactant and an alkylamine oxide type semipolar surfactant as essential components.

  The hydroxyalkyl ether carboxylic acid type anionic surfactant used in the present invention is represented by the following general formula (1).

(Wherein R ₁ represents an alkyl group or alkenyl group having 6 to 20 carbon atoms, and X represents hydrogen, an inorganic cation, or an organic cation).

Specifically, R ₁ is a saturated or unsaturated, linear or branched alkyl group having 6 to 20 carbon atoms, preferably 8 to 14 carbon atoms.

X is hydrogen, an inorganic cation, or an organic cation. Specific examples of the inorganic cation include alkali metal ions (Li ⁺ , Na ⁺ , K ⁺ ). Specific examples of the organic cation include , Ammonium ion (NH ₄ ⁺ ), triethanolamine, monoethanolamine, arginine, lysine, N-methyltaurine salt and the like.

  As such a hydroxyalkyl ether carboxylic acid type anionic surfactant represented by the above general formula (1), Levon HSA-3 (dodecane-1,2-diol) sold by Sanyo Chemical Industries, Ltd. And sodium acetate ether).

  Moreover, the alkylamine oxide type semipolar surfactant used in the present invention is represented by the following general formula (2).

(In the formula, R ₂ represents an alkyl group having 8 to 22 carbon atoms, an alkenyl group or a polyoxyethylene alkyl ether group, and R ₃ and R ₄ represent an alkyl group having 1 to ₄ carbon atoms, an alkoxy group, and a hydroxyalkyl group. It shows the selected one.)

Specifically, R ₂ is a saturated or unsaturated, linear or branched alkyl group having 8 to 22 carbon atoms, preferably 10 to 18 carbon atoms.

  As a specific example of such an alkylamine oxide type semipolar surfactant represented by the general formula (2), Unisafe A-LMR (lauryl dimethylamine oxide) manufactured by NOF Corporation may be mentioned. .

  In the keratolytic detergent composition according to the present invention, the hydroxyalkyl ether carboxylic acid type anionic surfactant and the alkylamine oxide type semipolar surfactant have a weight ratio of 60 in the composition. : 40 to 10:90, more preferably 30:70 to 10:90. If the content of the hydroxyalkyl ether carboxylic acid type anionic surfactant with respect to the alkylamine oxide type semipolar surfactant is more than 60/40, the irritation to the skin becomes too strong and the keratin solubility decreases. To do. Conversely, even if the content of the hydroxyalkyl ether carboxylic acid type anionic surfactant with respect to the alkylamine oxide type semipolar surfactant is less than 10/90, the skin irritation becomes too strong, and the keratin Solubility decreases.

  Further, in the keratolytic detergent composition according to the present invention, the content of the hydroxyalkyl ether carboxylic acid type anionic surfactant and the alkylamine oxide type semipolar surfactant is less irritating to the skin, and It is not particularly limited as long as it can provide a high keratolytic effect, but the content of hydroxyalkyl ether carboxylic acid type anionic surfactant and alkylamine oxide type semipolar surfactant is not limited. The total is preferably from 2 to 30% by weight, more preferably from 3 to 20% by weight as the effective amount of the surfactant, based on the entire composition. If the total content of the hydroxyalkyl ether carboxylic acid type anionic surfactant and the alkylamine oxide type semipolar surfactant is less than 2% by weight, a sufficient keratolytic effect may not be obtained. On the other hand, if the amount is more than 30% by weight, the skin irritation may become too strong.

  As described above, the keratolytic detergent composition according to the present invention, in which the hydroxyalkyl ether carboxylic acid type anionic surfactant and the alkylamine oxide type semipolar surfactant are contained as essential components, High safety and keratolytic effect. In addition, since it has good foaming properties, it is suitable for use as a cleaning agent.

<Bactericidal component>
In addition, the keratolytic detergent composition according to the present invention may contain a bactericidal component as long as the effects of the present invention are not impaired. As the bactericidal component, any one having a bactericidal effect can be used. Specific examples include benzalkonium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, chlorhexidine, trichlorocarbanilide, triclosan, zinc pyrithione, And hinokitiol. These bactericidal components may be used alone or in combination of two or more.

  Thus, when the keratolytic detergent composition according to the present invention contains a bactericidal component, for example, a detergent composition for preventing or treating acne and a detergent composition for preventing or treating athlete's foot It can be used as a product.

<Moisturizing ingredient>
In addition, the keratolytic detergent composition according to the present invention may contain a moisturizing component as long as the effects of the present invention are not impaired. As the moisturizing component, any one having a moisturizing effect can be used. Specific examples include 1,3-butylene glycol, glycerin, xylitol, propylene glycol, diglycerin, dipropylene glycol, polyethylene glycol, 1, Examples include 2-pentanediol, 1,2-hexanediol, sorbitol, isopropylene glycol, 1,2-octanediol, 2,4-hexylene glycol, and the like. These moisturizing components may be used alone or in combination of two or more.

  In this way, when the keratolytic detergent composition according to the present invention contains a moisturizing component, it is possible to eliminate the feeling of tension after use and to provide a detergent composition with better usability. be able to. In addition, when moisturizing component is contained in the keratolytic detergent composition according to the present invention, the content of the moisturizing component with respect to the whole composition is preferably 1 to 30% by weight, and more preferably 3 to 15% by weight. If the content of the moisturizing component relative to the whole composition is less than 1% by weight, a good moisturizing effect may not be obtained. Conversely, if it exceeds 30% by weight, the keratolytic effect is impaired or sticky. A feeling may occur.

<Skin prevention ingredients>
In addition, the keratolytic detergent composition according to the present invention may contain an anti-skin component as long as the effects of the present invention are not impaired. As the skin irritation component, any of those known to have an effect of preventing skin irritation can be used. Specific examples include dipotassium glycyrrhizinate, allantoin, tranexamic acid, vitamins, amino acids and coconut extract, and loquat leaf extract. And plant extracts such as In addition, these rough skin prevention components may be used independently, or 2 or more types may be used together.

  In this way, when the keratolytic detergent composition according to the present invention contains an anti-skin component, it is possible to provide a detergent composition with less burden on the skin.

<Scrubbing agent>
Further, the keratolytic detergent composition according to the present invention may contain a scrub agent within a range not impairing the effects of the present invention. As the scrub agent, any known one can be used. Specific examples include spherical silica P-1500 (manufactured by Catalytic Chemical Industry Co., Ltd.), SST-H1000 (manufactured by Kakuhachi Fish Scale), Tospearl 2000- B (manufactured by Toshiba Silicone), hydroxyapatite (manufactured by Advanced), calcium alginate, spherical polyethylene SS (manufactured by Sumitomo Seika Co., Ltd.), sun wax 151P (manufactured by Sanyo Chemical Industries, Ltd.), PW powder M-2010 (Parico) Product), spherical polyethylene SS-2 (manufactured by Sumitomo Seika Co., Ltd.), nylon SP-500 (manufactured by Nikko Riken Sangyo Co., Ltd.), Celluloflow C-25 (manufactured by Chisso Corporation), and the like.

  Thus, when a scrub agent is contained in the keratolytic detergent composition according to the present invention, the keratolytic effect can be further enhanced by the peeling effect of the scrub agent.

<Other ingredients>
In the keratolytic detergent composition of the present invention, within the range that does not impair the effects of the present invention, components that are usually blended in the detergent composition as necessary, for example, water-soluble polymers having a thickening effect , Cationic polymer / amphoteric polymer / nonionic polymer, metal ion sequestering agent (chelating agent), preservative, deodorant, pigment, fragrance, granule, capsule, etc. Good.

  In addition, the keratolytic detergent composition according to the present invention can be used in any conventionally known form such as gel or liquid.

  The keratolytic detergent composition according to the present invention can be prepared by a conventionally known method. For example, a liquid keratolytic detergent composition can be prepared by dissolving various components in a solvent such as water or alcohol.

  In addition, the gel-like keratolytic detergent composition is prepared by previously moistening a water-soluble polymer having a thickening effect (such as a mixture of xanthan gum and hydroxyethyl cellulose) with a humectant (such as 1,3-butylene glycol). , Add to the main kettle filled with purified water, disperse and heat dissolve, then add other ingredients (the above-mentioned anionic surfactant, semipolar surfactant, etc.), and finally scrub agent if necessary Can be prepared by adding and stirring and mixing and then cooling. In this preparation method, a thickening base material is prepared with a water-soluble polymer having a thickening effect, and then other compounding components (the above-mentioned anionic surfactant, semipolar surfactant, etc.) are added. However, it is also possible to add a water-soluble polymer having a thickening effect to a uniform mixture of various components excluding a water-soluble polymer having a thickening effect, thereby increasing the viscosity to form a gel.

  The keratolytic detergent according to the present invention is a container in which a container is filled with the above-mentioned keratolytic detergent composition according to the present invention. The form of the container is not particularly limited, and specific examples include a bottle-type container, a tube-type container, a dispenser container with a pump, and a pump former container. A keratolytic detergent using a dispenser container or a pump former container is excellent in convenience because an appropriate amount of a keratin detergent composition can be taken out during use. Moreover, since only the usage amount can be taken out, hygiene is not impaired even if a plurality of people share and use it. Further, the keratolytic detergent using the pump former container is more convenient because the keratolytic cleaning composition can be taken out in the form of foam when used. In addition, when filling a pump former container, it is preferable that the keratolysis detergent composition is made into a liquid state.

  EXAMPLES Hereinafter, although an Example is given and this invention is demonstrated in detail, this invention is not limited to these Examples.

<Examples 1-12 and Comparative Examples 1-8>
The keratolysis detergent composition which concerns on Examples 1-12 and Comparative Examples 1-8 with the compounding component and compounding quantity shown to the following Tables 1-3 was prepared by the usage shown next. In addition, all the component amounts described in Tables 1 to 3 are converted into pure components.

  The keratolytic detergent compositions according to Examples 1 to 12 and Comparative Examples 1 to 3 first measured Levon HSA3P as an anionic surfactant and Unisafe A-LMR as a semipolar surfactant, Thereafter, purified water was added and dissolved by stirring. In addition, the keratolytic detergent compositions according to Comparative Examples 4 to 8 were prepared by first measuring raw materials other than purified water, and then adding purified water and stirring and dissolving. Comparative Example 8 was prepared by dissolving lactic acid and palmityldimethylaminoacetate betaine in 70 ° C. purified water and emulsifying cetyl ethylhexanoate using a homogenizer.

  “Keratolytic”, “safety”, and “foaming” of each of the keratolytic detergent compositions according to Examples 1 to 12 and Comparative Examples 1 to 8 thus prepared were evaluated as follows. It was evaluated by. The results are shown in Tables 1 to 3 above.

[Keratosolubility]
The keratin solubility was determined by the following method. That is, the epidermis that has been immersed in warm water at 60 ° C. for 1 minute and peeled off from ice-cold pork skin is treated with 0.1% trypsin for 30 minutes at a temperature of 37 ° C. to remove viable cells, A layer was obtained. This stratum corneum is washed with water and dried, then cut into a size of 0.5 cm × 0.5 cm, immersed in 15 ml of a test sample (keratin dissolution detergent composition), and stored in a thermostatic bath at 25 ° C. did. The degree of collapse of the stratum corneum at this time was observed with the naked eye, and the solubility was evaluated according to the following evaluation criteria.

A: The stratum corneum is disintegrated very finely.
○: The stratum corneum has collapsed.
Δ: The stratum corneum is slightly disintegrated.
X: The stratum corneum is not disintegrated at all.

[safety]
Safety was determined by the following cytotoxicity test. That is, each sample in which the dilution ratio of the keratolytic detergent composition was changed was added to SIRC cells (rabbit cornea-derived established cells) cultured in 96-well plates. Then, each SIRC cell to which each sample was added was stained with crystal violet, and the absorbance at 595 nm of the stained portion was measured. The obtained when showing 50% of the absorbance of the absorbance in the case without addition of the keratolytic detergent composition, keratolytic detergent composition density LD ₅₀ value (survival rate of 50% strength). And safety was evaluated according to the following evaluation criteria.

A: LD ₅₀ value is a concentration of 0.1% or more ○: LD ₅₀ value is a concentration of 0.05% or more and less than 0.1% Δ: LD ₅₀ value is a concentration of 0.01% or more and less than 0.05% ×: LD ₅₀ value is less than 0.01%

[Foaming]
400 ml of a sample (keratin dissolution detergent composition) was stirred using a cylindrical cylinder with a stirrer at a temperature of 40 ° C., the amount of foam was measured, and the foamability was evaluated according to the following evaluation criteria.

◎: Bubble amount 2000 ml or more ○: Bubble amount 1500 ml or more to less than 2000 ml Δ: Bubble amount 1000 ml or more to less than 1500 ml ×: Bubble amount less than 1000 ml

  From the results shown in Tables 1 to 3, Example 1 containing a hydroxyalkyl ether carboxylic acid type anionic surfactant (Levon HSA3P) and an alkylamine oxide type semipolar surfactant (Unisafe A-LMR) -12 are conventional keratolytic compositions in which glycolic acid, malic acid, lactic acid, trichloroacetic acid, sodium ascorbate phosphate, betaine palmitate dimethylaminoacetate, and cetyl ethylhexanoate are blended as keratolytic components It was recognized that it was excellent in keratin solubility, safety, and foaming property as compared with products (Comparative Examples 4 to 8).

  Moreover, the weight ratio of anionic surfactant (Levon HSA3P) and semipolar surfactant (Unisafe A-LMR) is 60:40 from the comparison with Examples 1-12 and Comparative Examples 1-3. -10: 90, it was recognized that better keratolytic properties and safety were exhibited as compared with conventional keratolytic compositions (Comparative Examples 4-8).

  Furthermore, from the results shown in Examples 1 to 12, the larger the total amount of the anionic surfactant (Levon HSA3P) and the semipolar surfactant (Unisafe A-LMR), the more keratolytic and foaming properties are. It is recognized that the smaller the amount, the higher the safety, and when the total amount of the anionic surfactant (Levon HSA3P) and the semipolar surfactant (Unisafe A-LMR) is 3 to 20% by weight (ie, In the case of Examples 5 to 8), in particular, it was observed that all of the keratin solubility, safety, and foaming properties were good.

<Example 13>
The keratolytic detergent composition of Example 13 that can be applied as a detergent for foot care was prepared by the following method. In addition, the compounding components and compounding amounts of the keratolytic detergent composition of Example 13 are as shown in Table 4.

  That is, first, Levon HSA3P as an anionic surfactant, Unisafe A-LMR as a semipolar surfactant, and 1,3-butylene glycol (humectant) were stirred and dissolved by adding purified water. . To this, triclosan (bactericidal agent) dissolved in ethanol was added. Furthermore, the tea dry distillation extract (deodorant) was added, and the whole was stirred, mixed and dissolved to obtain a keratolytic detergent composition as a foot care detergent according to Example 13.

  The keratolytic detergent composition of Example 13 is used for washing feet by adding water to the foamed foam as appropriate and applying to the foot. The keratolytic detergent composition attached to the foot is washed away with water after washing.

  In such use, the foaming condition of the keratolytic detergent composition of Example 13 was good. In addition, a feeling of smoothness was obtained on the feet after washing. Furthermore, there was no irritation such as tingling of the foot during and after washing.

<Example 14>
A keratolytic detergent composition of Example 14 that can be applied as an acne detergent was prepared by the following method. In addition, the compounding components and compounding amount of the keratolytic detergent composition of Example 14 are as shown in Table 5.

  That is, first, Levon HSA3P as an anionic surfactant, Unisafe A-LMR as a semipolar surfactant, and 1,3-butylene glycol (humectant) were stirred and dissolved by adding purified water. . To this, add a solution of triclosan (disinfectant) dissolved in ethanol, and then add a solution of dipotassium glycyrrhizinate (anti-rough skin) in some purified water, and stir and dissolve the whole. Thus, a keratolytic detergent composition as an acne detergent according to Example 14 was obtained.

  For example, the keratolytic detergent composition of Example 14 is applied to the face or body by adding water and foaming as appropriate, and used for washing the face or body. In addition, the keratolytic detergent composition attached to the face or body is washed away with water after washing.

In such use, the foaming condition of the keratolytic detergent composition of Example 14 was good. Also, a smooth feeling was obtained on the face or body after washing. Furthermore, there was no irritation such as irritation of the face or body during and after washing.

Claims (9)

The following general formula (1)

(Wherein R ₁ represents an alkyl group or alkenyl group having 6 to 20 carbon atoms, and X represents hydrogen, an inorganic cation, or an organic cation.) An anionic surfactant of the hydroxyalkyl ether carboxylic acid type When,
The following general formula (2)

(In the formula, R ₂ represents an alkyl group having 8 to 22 carbon atoms, an alkenyl group or a polyoxyethylene alkyl ether group, and R ₃ and R ₄ represent an alkyl group having 1 to ₄ carbon atoms, an alkoxy group, and a hydroxyalkyl group. An alkylamine oxide type semipolar surfactant represented by the following formula:
A keratolytic detergent composition, wherein a weight ratio of the anionic surfactant and the semipolar surfactant in the composition is 60:40 to 10:90. A keratolytic detergent composition according to claim 1,
A keratolytic detergent composition comprising 3 to 20% by weight of the anionic surfactant and the semipolar surfactant in total in the composition. A keratolytic detergent composition according to claim 1 or 2,
A keratolytic detergent composition comprising a bactericidal component. A keratolytic detergent composition according to claim 3,
The keratolytic agent characterized by containing at least one selected from the group consisting of benzalkonium chloride, chlorhexidine hydrochloride, chlorhexidine gluconate, chlorhexidine, trichlorocarbanilide, triclosan, pyrithione zinc, and hinokitiol as the bactericidal component. Cleaning composition. A keratolytic detergent composition according to any one of claims 1 to 4, wherein
A keratolytic detergent composition comprising a moisturizing component. A keratolytic detergent composition according to any one of claims 1 to 5, wherein
A keratolytic detergent composition comprising an anti-skin component. A keratolytic detergent composition according to any one of claims 1 to 6, wherein
A keratolytic detergent composition comprising a scrub agent. A keratolytic detergent composed by filling a container with a keratolytic detergent composition,
A keratolytic detergent comprising the keratolytic detergent composition filled with the keratolytic detergent composition according to any one of claims 1 to 7. A keratolytic detergent configured by filling a pump former container with a keratolytic detergent composition,
A keratolytic detergent, wherein the keratolytic detergent composition is filled with the composition according to any one of claims 1 to 6.