JP2009222451A - Automatic analyzer - Google Patents

Abstract

【Task】
The problem to be solved by the invention tends to be inefficient in the current operation of the equipment, which is to improve the management work that compares the measurement results of the normal measurement items and the control sample, that is, the accuracy management work flow by the laboratory technician, In the above comparison work, it is possible to easily realize statistical accuracy management work that has been difficult until now, and to contribute to improvement of reliability of the accuracy management work.
[Solution]
The application of the present invention can be realized by improving application software for controlling the operation screen of the automatic analyzer and displaying a specific number of managed sample measurement results simultaneously with the measurement results of the normal measurement items.
[Selection] Figure 4

Description

  The present invention relates to an automatic analyzer that requires operation of internal accuracy management, and more particularly to an automatic analyzer that requires periodic operation of an accuracy control sample from the viewpoint of stability of analysis data.

  Conventional automatic analyzers dispense samples consisting of biological samples such as blood and urine from sample containers to reaction vessels on the reaction line, and dispense reagents from reagent vessels to reaction vessels on the reaction line, The liquid mixture of the sample and the reagent is measured by a measuring means such as a photometer.

  Further, as a daily quality control means in a laboratory, a quality control sample is requested to be analyzed at a specific cycle interval, and is generally operated for the purpose of tracing the measurement result of a normal measurement item. An example of such an accuracy management method is described in Patent Document 1.

JP-A-62-862

  When operating the above-mentioned quality control sample, the reference is mainly the control sample measurement result immediately before the current target or the control sample measurement result of the previous cycle, and the operation is mainly from the viewpoint of traceability. . In addition, as described above, most of the functions on the operation screen of the device support the search of the immediately preceding or past data, and the work efficiency of the comparison between the normal measurement item measurement result and the quality control sample measurement result is reduced. There was a possibility that stable accuracy control would be difficult due to human error such as overlooked measurement data.

  In the present invention, as a means for reliably improving the management accuracy, an arbitrary number of management sample measurement results before and after the analysis, that is, a specific range number is displayed on the screen together with the measurement results of the normal measurement items, or output to a peripheral device. Provide a means for statistically determining the control sample measurement results. In particular, the management sample measurement results after measurement of the normal measurement items, which have not been regarded as important so far, can be displayed and easily handled as a material for statistical judgment. Therefore, it is possible to greatly contribute to the work efficiency of the entire specimen inspection work.

  The configuration of the present invention for achieving the above object is as follows.

  An automatic analyzer including a display unit that displays a measurement result of a general sample and a measurement result of a quality control sample that guarantees the measurement result on the same screen for each measurement item. In such an automatic analyzer, it is preferable that the measurement result of the quality control sample is further displayed for a total of four times, two times before the measurement of the general sample and two times after the measurement. Further, the measurement result of the general sample displays one sample on one screen, displays the measurement results of the measurement items measured for the sample in a vertical arrangement, and designates any of the measurement results arranged in the vertical direction. Thus, it is preferable to display the measurement result of the quality control sample that guarantees the measurement result.

  The inspection engineer's accuracy management work flow can be improved and work efficiency can be greatly improved.

  Embodiments of the present invention will be described below in order from FIG.

  FIG. 1 is a schematic view of the periphery of a dispensing mechanism of a general automatic analyzer. Since the function of each part is well-known, detailed description is omitted. The sampling arm 2 of the sampling mechanism 1 moves up and down and rotates. Using the probe 105 attached to the sampling arm 2, the sample 7 in the sample container 101 arranged on the sample disk 102 rotating left and right is sucked and reacted. It is comprised so that it may discharge to the container 106. FIG. As can be seen from this figure, the sample container 101 is placed on the sample disk 102 in a universal arrangement in which the sample container 101 can be placed directly on the sample disk 102 or on the test tube (not shown). The thing of the structure which can respond is common.

  The configuration of the automatic analyzer in FIG. 1 will be further described. On the rotatable reagent disk 125, reagent bottles 112 corresponding to a plurality of analysis items to be analyzed are arranged. The reagent dispensing probe 110 attached to the movable arm dispenses a predetermined amount of reagent from the reagent bottle 112 to the reaction container 106.

  The sample dispensing probe 105 performs a sample suction operation and a discharge operation in accordance with the operation of the sample syringe pump 107. The reagent dispensing probe 110 executes a reagent suction operation and a discharge operation in accordance with the operation of the reagent syringe pump 111. The analysis items to be analyzed for each sample are input from an input device such as a keyboard 121 or a CRT 118 screen. The operation of each unit in this automatic analyzer is controlled by the computer 103.

  As the sample disk 102 rotates intermittently, the sample container 101 is transferred to the sample suction position, and the sample dispensing probe 105 is lowered into the stopped sample container. When the tip of the dispensing probe 105 comes into contact with the liquid level of the sample along with the lowering operation, a detection signal is output from the liquid level detection circuit 151, and the computer 103 stops the lowering operation of the driving unit of the movable arm 2 based on the detection signal. Control as follows. Next, after a predetermined amount of sample is sucked into the dispensing probe 105, the dispensing probe 105 rises to the top dead center. While the dispensing probe 105 is sucking a predetermined amount of sample, the pressure detection circuit uses the signal from the pressure sensor 152 to detect the pressure fluctuation in the flow channel during the suction operation between the dispensing probe 105 and the sample pump 107 flow channel. When monitoring is performed at 153 and an abnormality is found in the pressure fluctuation during suction, an alarm is added to the analysis data because there is a high possibility that a predetermined amount has not been sucked.

  Next, the sampling arm 2 rotates in the horizontal direction, the sample dispensing probe 105 is lowered at the position of the reaction vessel 106 on the reaction disk 109, and the sample held in the reaction vessel 106 is discharged. When the reaction container 106 containing the sample is moved to the reagent addition position, a reagent corresponding to the corresponding analysis item is added from the reagent dispensing probe 110. As the sample and reagent are dispensed, the liquid level of the sample in the sample container 101 and the reagent in the reagent bottle 112 is detected. The sample and the mixture in the reaction vessel to which the reagent has been added are stirred by the stirrer 113. The reaction container containing the mixture is transferred to the measuring means 162, and simultaneously the shielding means by the actuator 160 is opened, and the luminescence value or absorbance of each mixture is measured by the photomultiplier 161 or the photometer as the measuring means. . The emission signal enters the computer 103 via the interface 104 via the A / D converter 116, and the concentration of the analysis item is calculated. The analysis result is printed out to the printer 117 via the interface 104 or output to the CRT 118 and stored in the hard disk 122 as a memory. After completion of photometry, the reaction vessel 106 is cleaned at the position of the cleaning mechanism 119. The cleaning pump 120 supplies cleaning water to the reaction container and discharges waste from the reaction container. In the example of FIG. 1, three rows of container holding portions are formed so that three rows of sample vessels 101 can be set concentrically on the sample disk 102, and the sample suction position by the sample dispensing probe 105 is in each row. One by one is set.

  Next, a general workflow for an inspection request in a hospital will be described below with reference to FIG. As a general routine measurement including accuracy management, first, an accuracy management item is measured, and after confirming that the measurement value is within the management value, measurement of the normal measurement item which is the next process is performed. The measurement cycle / frequency of quality control items naturally depends on the number of items to be measured, but the measurement is performed once each in the morning / afternoon, and the number of measurements of about 2 to 3 times / day is a typical numerical value. . Accordingly, as shown in FIG. 2, “measurement of quality control items” and “measurement of normal measurement items”, that is, (1)-(2), (3)-(4), (5)-(6) It can be seen that each is a set and has a very important relationship in managing the accuracy of the device output data.

  Accordingly, as shown in FIG. 3, some conventional automatic analyzers have a function of simultaneously displaying the measurement results of the accuracy management items on the screen as the measurement results of the normal measurement items. Some devices have a function of retrieving and displaying the measurement result.

  However, (4) the measurement result (current) of the normal measurement item shown in FIG. 2 (3) only the measurement result (current) of the accuracy management item is displayed, or (1) the accuracy management item of the past measurement result is displayed. Searching and displaying the measurement results (previous) only fulfills the function from the viewpoint of traceability.

  In other words, in quality control, the validity of the measurement result (current) of the normal measurement item is generally guaranteed after comparing the before and after value data, that is, (1) measurement of the quality control item. Results (previous), (3) Measurement results of quality control items (current), (6) Measurement results of quality control items (next time) By making a statistical judgment using these multiple data as judgment materials, (4) It is self-evident that it contributes to improving the certainty of the measurement result of the normal measurement item (this time).

  Next, an embodiment of the present invention will be described with reference to FIG.

  The case shown as Example 1 in FIG. 4 shows a specific example in which the current value and the previous and subsequent measurement results are displayed on the screen with respect to the current normal item measurement result. That is, (4) Normal item measurement results in FIG. 2 (1), (3), (5) (previous) (current) (next) quality management measurement results are displayed simultaneously, and the accuracy management measurement results ( It can be easily imagined that the value at the next time can be easily grasped, and the statistical judgment can be easily judged as a result.

  Next, the case shown as Example 2 in FIG. 4 is a specific example in which the measurement results as the preceding and following values are further expanded one layer at a time, and as described above, it becomes easier to make further statistical judgments and grasp the trend of the measurement results. In addition to improving the accuracy control, which is the purpose of the above, it is also possible to contribute to a significant improvement in workability of the inspection engineer who performs this work.

  Furthermore, when an abnormality is confirmed in the trend value before and after the measurement result, as shown in Example 2, it is possible to further enhance the workability of the inspection engineer by highlighting and displaying the specific measurement result.

  In the embodiment shown in FIG. 4, the front / rear value display once and the front / rear value display are shown as specific examples, but the number of times the front / rear value is displayed should be arbitrarily settable. The number of before and after values is not specified and details should not be mentioned.

  Further, in the embodiment shown in FIG. 3 and FIG. 4, the display on the operation screen is shown as a specific example. However, the display portion is specified on the operation screen in the present invention as described above, and details should not be mentioned.

Schematic which shows the whole analysis part structure of the automatic analyzer to which this invention is applied. 1 is a schematic diagram of the overall configuration of an automatic analyzer including a plurality of analysis units. Problems to be solved by the present invention. The example of an apparatus screen display of the automatic analyzer to which the present invention is applied.

Explanation of symbols

1 Sampling mechanism 10 Analysis unit 1
11 Analysis unit 2
12 Analysis unit 3
13 Analysis unit 4
14 Sample loading unit 15 Sample unloading unit 18 Sample transport unit 101 Sample container (sample container)
118 CRT (operation screen)

Claims (3)

  An automatic analyzer comprising a display means for displaying a measurement result of a general sample and a measurement result of a quality control sample that guarantees the measurement result on the same screen for each measurement item. The automatic analyzer according to claim 1, wherein
The automatic analysis apparatus is characterized in that the measurement result of the quality control sample displays a total of four times for two times prior to the measurement of the general sample and two times after the measurement. The automatic analyzer according to claim 1 or 2,
The measurement result of the general sample displays one sample on one screen, displays the measurement results of the measurement items measured for the sample in a vertical arrangement, and designates any of the measurement results arranged in the vertical direction. An automatic analyzer characterized in that the measurement result of a quality control sample that guarantees the measurement result is displayed.

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