JP2009155227A - Living body tissue repair promoting drug - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a living body tissue repair promoting drug which can be used in skin aging prevention, rejuvenation treatment, and beautification, can exhibit the effect of skin aging prevention, rejuvenation and the like equal to the administration of a female hormone, further promotes wound healing, and enables long-term, safe use without side effects. <P>SOLUTION: The living body tissue repair promoting drug has lavender oil and tea tree oil as active ingredients and promotes the damage of the skin tissue and/or the subcutaneous tissue of a living body. The active ingredient is an estrogenic action component, an antiandrogenic action component and/or a hyaluronic acid production promoting component. <P>COPYRIGHT: (C)2009,JPO&INPIT

Description

  The present invention is used as a medicine such as a functional external preparation for cosmetics, rejuvenation treatment, wound healing of skin tissue or subcutaneous tissue damaged by aging or wound, and repairs damage to living tissue. The present invention relates to a biological tissue repair promoting drug.

  Skin aging such as spots, wrinkles and sagging is caused by various external environmental factors including exposure to ultraviolet rays of sunlight and near infrared rays. Even if light exposure is shielded with a parasol, etc., or sun damage applied to the skin, UV protection agents, or near infrared protection agents prevent damage due to light exposure, internal hormones such as a decrease in female hormones may occur. Skin aging also progresses depending on factors.

  Such estrogen, a female hormone such as the follicular hormone, is produced in the ovary, placenta, adrenal cortex, etc., and its secretion increases from around puberty to promote secondary sexual characteristics and regulate the sexual cycle. However, secretion is remarkably reduced by hormonal imbalance and aging, especially after menopause.

  When female hormone decreases, fibroblast collagen production decreases and hyaluronic acid production decreases, resulting in aging of the skin and subcutaneous tissues throughout the body, fine lines, large wrinkles, sagging, The firmness, elasticity, and transparency disappear, wound healing is delayed, and hair loss is observed.

  Therefore, even in a young woman, when the female hormone balance is lost due to stress or the like and the female hormone decreases, the aging of the skin proceeds. Especially in women after menopause, due to a significant decrease in female hormones due to aging, skin aging progresses rapidly, and it appears that they are getting old rapidly.

  Therefore, in order to prevent skin rejuvenation, aging prevention and beauty, countermeasures such as skin massage, and pharmacotherapy such as subcutaneous injection of hyaluronic acid and administration of female hormones are performed.

  In particular, female hormones have dramatic effects such as skin rejuvenation, but there are many cases in which side effects such as carcinogenesis appear.

  Lavender oil and tea tree oil are fragrances commonly used for aromatherapy. However, as in Non-Patent Document 1, boys dilute and contain any one of them in puberty. When exposed, even without female hormones themselves, they sometimes develop estrogenic effects and induce gynecomastia.

  Moreover, both lavender oil and tea tree oil are highly irritating, and direct application of each of them may cause redness, itchiness, and dryness, and the concentration must be very low when used for external preparations and cosmetics. It was difficult to get the skin rejuvenation effect.

Derek V. Henley et al., The New England of Journal Medicine, 356, 2007, pp. 479-485.

  The present invention was made to solve the above problems, and can be used for skin aging prevention, rejuvenation treatment, beauty, and exhibits effects such as skin aging prevention and rejuvenation equivalent to female hormone administration, Another object of the present invention is to provide a biological tissue repair accelerating drug that promotes wound healing and can be used safely for a long period with few side effects.

  The biological tissue repair-promoting agent according to claim 1, which has been made to achieve the above-mentioned object, contains lavender oil and tea tree oil as active ingredients, so that skin tissue of the living body, and It is characterized by promoting repair of damage to subcutaneous tissue.

  The biological tissue repair-promoting agent according to claim 2 is the agent according to claim 1, wherein the active ingredient is an estrogen-like active ingredient, an antiandrogen-like active ingredient, and / or a hyaluronic acid production-promoting active ingredient. It is characterized by that.

  The biological tissue repair promoting agent according to claim 3 is the agent according to claim 1, wherein the estrogen-like active ingredient and the antiandrogen-like active ingredient promote collagen production of fibroblasts, and the hyaluronic acid Improves the rejuvenation, wrinkles or sagging of the whole body skin or subcutaneous tissue by the production promoting component, and restores the tension, elasticity, texture, deposition or transparency of the whole body skin or subcutaneous tissue by the hyaluronic acid production promoting component, Wound healing is promoted by the estrogen action, and / or hair growth or hair growth at a hair loss site is promoted by the antiandrogen action.

  The biological tissue repair-promoting agent according to claim 4 is the agent described in claim 1 and is an external preparation.

  The biological tissue repair promoting drug according to claim 5 is the drug described in claim 4, wherein the external preparation is a cosmetic, an external medicine, or an external quasi drug.

  The biological tissue repair accelerating agent according to claim 6 is the agent according to claim 1, and includes higher alcohol derivatives, aralkyl alcohol derivatives, long chain branched fatty acid derivatives, higher fatty acid derivatives, higher fatty acid metal soaps, nitrogen-containing derivatives. , Hydrocarbon derivatives, fats and oils, waxes, lanolins, sphingophospholipids, phospholipids, phospholipid derivatives, sterols, sapogenins, saponins, sterol esters, lipid complexes, oxyacid esters, It contains polyhydric alcohol fatty acid esters, silicones, and / or fluorine-based oils.

  The biological tissue repair accelerating agent according to claim 7 is the agent described in claim 1, and includes a moisturizer, a touch improver, a surfactant, a polymer, a thickener, a gelling agent, a solvent, a propellant, Antioxidants, reducing agents, oxidizing agents, antiseptics, antibacterial agents, chelating agents, pH adjusters, acids, alkalis, powders, inorganic salts, UV absorbers, whitening agents, vitamins, vitamin derivatives, anti-inflammatory agents, Anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, astringents, astringents, cooling sensations, warming sensations, wound healing promoters, stimulation relieving agents, analgesics Agent, cell activator, plant extract, animal extract, microorganism extract, antipruritic agent, keratolytic agent, keratolytic agent, peeling agent, antiperspirant, refreshing agent, enzyme, nucleic acid, fragrance, pigment, colorant, dye, pigment And / or water.

  The biological tissue repair accelerating agent according to claim 8 is the agent according to claim 7, and includes normal water, purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkaline ionized water, electrolytic acidic ionized water, Ionic water and / or cluster water.

  The biological tissue repair accelerating agent according to claim 9 is the agent according to claim 7, wherein the plant extract, the animal extract or the microorganism extract is extracted from a plant tissue or animal tissue, or from a microorganism tissue. It is an extract or a microbial product.

  The biological tissue repair accelerating drug according to claim 10 is the drug according to claim 1, characterized by containing 0.0001 to 99.9% by mass of the active ingredient.

  The biological tissue repair-promoting agent of the present invention uses the estrogenic action, antiandrogenic action, and hyaluronic acid production promoting action of lavender oil and tea tree oil to prevent aging and rejuvenation of biological tissues such as skin tissue and subcutaneous tissue. It is useful as a functional cosmetic / quasi-drug that can be used for treatment and beauty, and as a pharmaceutical that promotes healing of wounds in living tissues.

  This biological tissue repair-promoting drug has the effects of preventing aging, rejuvenation, and beauty of biological tissue equivalent to female hormone administration. Moreover, there is no risk of side effects such as carcinogenesis due to the administration of female hormones themselves. Furthermore, due to the synergistic effect of including both lavender oil and tea tree oil as active ingredients, a sufficient effect can be obtained at a lower concentration than when only one of them is contained, and harmful effects such as redness, itchiness, and dryness can be obtained. Skin rejuvenation can be achieved without the possibility of causing an event.

  In addition, lavender oil and tea tree oil are not generally preferred because they not only have strong skin irritation as a topical preparation, but also the odor of the volatile component is too strong. However, by using both in combination, the odor irritation can be alleviated and can be used as a drug such as a practical external preparation without reducing the efficacy.

  Furthermore, even if they are used continuously for a long time or in large quantities, if both oils are contained, sufficient effects can be expected even if the respective concentrations are low, and gynecomastia in adolescent boys There are no side effects such as onset, adverse events such as redness, itchiness and dryness can be avoided, and the irritating odor can be alleviated.

Preferred form for carrying out the invention

  Hereinafter, although the preferable form for implementing this invention is demonstrated in detail, the scope of the present invention is not limited to these forms.

  The biological tissue repair-promoting agent of the present invention comprises lavender oil and tea tree oil as active ingredients that are an estrogen-like active ingredient, an antiandrogen-like active ingredient, and a hyaluronic acid production-promoting active ingredient, and an oily ingredient that is a solvent as a substrate. It contains.

  Lavender oil is a vegetable oil, for example, an essential oil obtained by a technique such as steam distillation or extraction from flowers or branches and leaves such as Lavandula vera.

  Tea tree oil is a vegetable oil, and is an essential oil obtained from a leaf of a tea tree (Melaleuca Alternifolia) by a method such as steam distillation or extraction.

  The blending amount of lavender oil and tea tree oil, which are active ingredients in the biological tissue repair promoting drug, can be appropriately selected according to the type of the active ingredient and the shape of the biological tissue repair promoting drug, and is not particularly limited. , Preferably 0.0001 to 99.9% by mass, more preferably 0.001 to 50% by mass, and 0.01 to 20% by mass with respect to the total mass of the biological tissue repair promoting agent. And even more preferred.

  The mixing ratio of lavender oil and tea tree oil in the biological tissue repair accelerating agent is preferably 1: 100 to 100: 1.

  The product form of the biological tissue repair accelerating drug is not particularly limited, but is preferably an external preparation, and more preferably a cosmetic, an external medicine, or an external quasi drug.

  More specifically, the product forms of the tissue repair promoting drug include perfume, eau de toilette, eau de cologne, shampoo, rinse, hair conditioning, hair treatment, hair spray, hair wax, hair gel, water grease, set lotion, color lotion, hair Tonic, Hair Liquid, Pomade, Hair Cream, Hair Blow, Split Hair Coat, Hair Oil, Hair Color Agent, Gray Hair Dye, Hair Manicure, Hair Growth Agent, Facial Cleanser, Cleansing Foam, Powder Washing, Face Wash Powder, Cleansing Gel, Cleansing Gel, Cleansing Cream, Cleansing milk, cleansing oil, cleansing mask, lotion, soft lotion, astringent lotion, cleaning lotion, multi-layer lotion, emulsion, emollient lotion, moisture Lotion, milky lotion, nourishing lotion, nourishing milk, sun protect, sun protector, ultraviolet (UV) care milk, sunscreen, makeup lotion, makeup cream, hand lotion, hand cream, body lotion, body cream, emollient cream, Moisture cream, nutrition cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, soap, cosmetic soap, medicated soap, medicated soap, liquid soap, shaving soap, synthetic soap, Body shampoo, body rinse, body powder, pack, mask, essence, moisturizing essence, whitening essence, UV protection essence , Cosmetics, basic cosmetics, white powder, dusting powder, foundations, lipsticks, lip balm, lip gloss, blusher, eyeliner, mascara, eye shadow, eyebrow, eyebrow, nail enamel, enamel remover, nail treatment, Examples include deodorant cosmetics, insect repellent sprays, ointments, patches, lotions, and bath preparations.

  Although the example which uses a biological tissue repair promotion agent as an external preparation was shown, as long as the said effect can be achieved, you may use it for another use. For example, this biological tissue repair promoting agent can be used as a fragrance, deodorant, aroma candle, incense, stationery, purse, bag, miscellaneous goods such as shoes, clothing such as underwear, clothes, hats, stockings, and socks. May be included. Furthermore, this biological tissue repair promoting drug may be included in inhaled products such as inhaled pharmaceuticals, beverages, and foods.

  The dosage form of the biological tissue repair promoting drug is not particularly limited, and examples thereof include a liquid, a powder, a granule, an aerosol, a solid, and a gel. The biological tissue repair promoting drug may be added with any substrate depending on the product form or dosage form.

  Substrates include, for example, cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, aralkyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, seraalkyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2 -Higher alcohols such as octyldodecanol and dimer diol; aralkyl alcohols such as benzyl alcohol and derivatives thereof; lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, behenic acid, undecylenic acid, 1,2-hydroxystearic acid Acid, palmitooleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexa Long-chain linear or branched fatty acid derivatives such as decanoic acid and anteisohenicoic acid, long-chain cyclic or branched higher fatty acid derivatives such as dimer acid and hydrogenated dimer acid, and their Metal soaps such as aluminum salt, calcium salt, magnesium salt, zinc salt and potassium salt; nitrogen-containing derivatives such as amide; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefin oligomer, polyisobutene, Hydrocarbons such as hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, solid paraffin; candelilla wax, carnauba wax, rice wax, wax, beeswax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, Micro crystal Waxes such as palm wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, ethylene / propylene copolymer; palm oil, palm oil, palm kernel oil, safflower oil, olive oil, castor oil, avocado oil, sesame oil, tea oil, evening primrose oil, Wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadow foam oil, persic oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, Vegetable oils such as cacao butter, shea fat, hydrogenated palm oil, hydrogenated castor oil, jojoba oil, hydrogenated jojoba oil, animal fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, turtle oil Animal waxes such as whale wax, lanolin, orange luffy oil; liquid lanolin, Lanolins such as original lanolin, adsorptive purified lanolin, lanolin acetate, lanolin acetate, hydroxy lanolin, polyoxyethylene lanolin, lanolin fatty acid, hard lanolin fatty acid, lanolin alcohol, lanolin alcohol acetate, and acetates thereof; lecithin, phosphatidylcholine, phosphatidyl Sphingophospholipids such as ethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingomyelin; phospholipids such as phosphatidic acid and lysolecithin; phospholipid derivatives; sterols; sapogenins; saponins; sterol esters; Oxyacid esters; polyhydric alcohol fatty acid esters; fatty acid alkanolamides; silicones; It is. These may be used alone or in combination.

  Lavender oil and tea tree oil diluted with these substances in biological tissue repair-promoting drugs act as female hormone analogs and act directly on female hormone receptors, which is comparable to the effects of female hormone administration. The effect is expressed.

  For tissue repair accelerators, moisturizers, feel improvers, surfactants, polymers, thickeners, gelling agents, solvents, propellants, antioxidants, reducing agents, oxidizing agents, antiseptics, antibacterial agents , Chelating agents, pH adjusters, acids, alkalis, powders, inorganic salts, UV absorbers, UV absorbers, whitening agents, vitamins, vitamin derivatives, anti-inflammatory agents, anti-inflammatory agents, hair restoration agents, blood circulation promoters , Stimulant, hormones, anti-wrinkle agent, anti-aging agent, astringent, astringent, cooling sensation, warming sensation, wound healing promoter, irritation relieving agent, analgesic, cell activator, plant extract, animal extract Microbial extract, antipruritic agent, exfoliating agent, exfoliating agent, exfoliating agent, antiperspirant, refreshing agent, enzyme, nucleic acid, fragrance, coloring matter, coloring agent, dye, pigment, water may be added. These may be added alone or in combination.

  Water is ordinary water such as tap water and industrial water; purified water such as ion exchange water and distilled water; hard water; soft water; natural water such as ground water and river water; deep ocean water; electrolytic alkaline ion water, electrolysis Acidic ionic water, ionic water; and cluster water.

  Plant extracts, animal extracts, and microbial extracts are extracts from plant tissues or animal tissues, extracts from microbial tissues, or microbial products, and more specifically, iris extracts, ashitaba extract, asunalo extract, asparagus. Gas extract, Avocado extract, Avocado oil, Achacha extract, Almond extract, Almond oil, Altea extract, Arnica extract, Aloe extract, Apricot extract, Apricot kernel extract, Ginkgo biloba extract, Inkkou extract, Fennel extract, Turmeric extract, Oolong tea extract, Ouurushi extract, Ages extract, Echinacea leaf extract, Enmeo extract, Ogon extract, Oat extract, Auren extract, Barley extract, Panax ginseng extract, Hypericum extract, Oyster extract, Onionis extract, Dutch mosquito Shii extract, orange extract, orange oil, orange seed oil, seawater dried product, seaweed extract, oyster leaf extract, oyster extract, hydrolyzed elastin, hydrolyzed wheat powder, hydrolyzed silk, cuckoo extract, chamomile extract, oil-soluble chamomile extract, Carrot extract, Kawara mugwort extract, oat extract, calcade extract, licorice extract, oil-soluble licorice extract, kiwi extract, kiou extract, jellyfish extract, quinoa extract, cucumber extract, kiri leaf extract, guanosine, guava extract, cucumber extract, gardenia extract, kumazasa extract, Clara extract, walnut extract, chestnut extract, grapefruit extract, grapefruit oil, grapefruit seed oil, clematis extract, black rice extract, brown sugar extract, black vinegar, chlorella extract, Wax extract, Gentianana extract, Gennoshoco extract, Black tea extract, Yeast extract, Koboku extract, Coffee extract, Burdock extract, Rice extract, Rice fermented extract, Rice bran fermented extract, Rice germ oil, Comfrey extract, Collagen, Coriander extract, Cowberry extract, Saisin Extract, Psycho extract, Saitai extract, Saffron extract, Salvia extract, Soap extract, Sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Linden extract, Shimotake extract, Jatoba extract, Peonies extract , German chamomile extract, ginger extract, ginger root extract, birch extract, white fungus extract, ginger extract, horsetail extract, star Anise extract, Strawberry extract, Stevia extract, Stevia fermented product, Nishikawa willow extract, Atlantic kizuta extract, Hawthorn extract, Atlantic elder extract, Achillea millefolium extract, Prunus mint extract, Sage extract, Zeny mushroom extract, Senkyu extract, Senbu extract, Sakuhakuhi Extract, Daio Extract, Soybean Extract, Tiso Extract, Thyme Extract, Dandelion Extract, Lichen Extract, Tea Extract, Clove Extract, Chigaya Extract, Chinpi Extract, Evening Primrose Extract, Evening Primrose Oil, Bamboo Tea Extract, Capsicum Extract, Toki Extract, Tokinsenka Extract, Tonin Extract , Spruce extract, dokudami extract, tomato extract, nutmeg extract, natto extract, carrot extract, garlic extract, neroli extract, neroli oil, nova Extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, honey, clam extract, bilberry extract, parietaria extract, toad extract, bisabolol, hinoki extract, bifidobacteria extract, loquat extract, dandelion extract, fukinoto extract , Bukuryu extract, butcher bloom extract, grape extract (preferably containing polyphenols such as resveratrol), grape seed extract, grape seed oil (preferably containing polyphenols such as pignogenol) , Propolis, blackberry extract, blackcurrant extract, blackcurrant oil, blueberry extract, loofah extract, safflower extract, safflower oil, peppermint extract Bodaiju extract, button extract, hop extract, jojoba extract, jojoba oil, borage extract, borage oil, borage seed oil, mica squid extract, pine extract, maronier extract, mizuba pepper extract, mukuroji extract, melissa extract, peach extract, cornflower extract, Eucalyptus extract, Eucalyptus oil, Yukinoshita extract, Yuzu extract, Lily extract, Yokuinin extract, Artemisia extract, Raspberry extract, Eggshell membrane extract, Green tea extract, Apple extract, Rooibos tea extract, Ganoderma extract, Lettuce extract, Lemon extract, Lemon oil, Lemon seed Oil, lemon balm extract, forsythia extract, forsythia extract, rose extract, rose oil, rosemary extract, roman chamomile extract, royal jelly extract, and bitumen extract I can get lost. These may be used alone or in combination.

  Moreover, the perfume component generally used may be suitably added to the biological tissue repair promotion agent.

  The biological tissue repair promoting agent is preferably used as an external preparation, and may be directly applied to the skin or sprayed. After using it as soap or shampoo, it may be washed away, or it may be left on for a while like cosmetics. It may also be worn by impregnating or spraying clothes.

  Hereinafter, an example in which a biological tissue repair accelerating drug to which the present invention is applied is made as an experiment is shown in Examples.

Example 1
Jojoba oil (manufactured by Irid Corporation) 80 parts by weight Lavender oil (manufactured by La Drome Provencal) 10 parts by weight tea tree oil (manufactured by La Drome Provencal) 10 parts by weight Then, an external preparation for skin which is a biological tissue repair promoting agent was prepared.
Ten healthy healthy persons aged 18 to 84 years without skin disease were subjects, and this external preparation for skin was applied to the unilateral face and unilateral upper extremity once every night for 30 days at about 0.001 g / cm ² . . The effect of this skin external preparation was evaluated by comparing one side to which the skin external preparation was applied and one side to which the skin external preparation was not applied.

  In the half of the five people, from the day after the application, recovery of fine lines, sagging, elasticity, elasticity, and transparency of the applied part was confirmed by both the person concerned and a third party not involved in the experiment. In the other half, within 5 days after application, fine wrinkles, sagging, firmness, elasticity, and transparency of the applied part were confirmed by both the person and a third party not involved in the experiment. . Even after 30 days from the start of application, on the non-application side, no obvious changes or problem events were observed in all subjects, and on the application side, fine wrinkles, sagging, firmness, elasticity, and recovery of transparency were maintained. .

  It was confirmed that this biological tissue repair promoting drug has an estrogenic action and an antiandrogenic action.

  The biological tissue repair-promoting agent of the present invention promotes repair of damage to biological tissue, particularly aging of skin tissue and subcutaneous tissue, and is therefore used for beauty treatment, rejuvenation treatment, and wound treatment.

  In particular, when used for beauty and rejuvenation treatment, collagen production and hyaluronic acid production of fibroblasts are promoted by estrogen action and antiandrogen action, and rejuvenation of whole body skin, subcutaneous tissue, fine lines, by collagen and hyaluronic acid increase Improves wrinkles and sagging, restores elasticity, elasticity, and transparency, and also promotes wound healing by estrogen action and antiandrogen action to grow and grow male pattern hair loss sites. Prevents aging and rejuvenation of tissue morphology and function, delays aging. For this reason, it is possible to live a rich life both physically and mentally, and further, it is possible to reduce the medical expenses due to aging and to improve the health of the medical economy.

Claims (10)

  A biological tissue repair-promoting drug characterized by promoting repair of damage to skin tissue and / or subcutaneous tissue of a living body by containing lavender oil and tea tree oil as active ingredients.   The said active ingredient is an estrogen-like action component, an antiandrogen-like action component, and / or a hyaluronic acid production promotion action component, The biological tissue repair promotion drug of Claim 1 characterized by the above-mentioned.   The estrogen-like active ingredient and the anti-androgen-like active ingredient promotes collagen production of fibroblasts, and the hyaluronic acid production-promoting active ingredient improves rejuvenation, wrinkles or sagging of whole body skin or subcutaneous tissue, and the hyaluron Restoring tension, elasticity, texture, deposition or transparency of the whole body skin or subcutaneous tissue with an acid production promoting component, promoting wound healing by the estrogen action, and / or hair growth at a hair loss site by the antiandrogen action Alternatively, the body tissue repair promoting agent according to claim 1, which promotes hair growth.   The biological tissue repair-promoting agent according to claim 1, which is an external preparation.   The said external preparation is cosmetics, an external pharmaceutical, or an external pharmaceutical quasi-drug, The biological tissue repair promotion drug of Claim 4 characterized by the above-mentioned.   Higher alcohol derivatives, aralkyl alcohol derivatives, long-chain linear, branched or cyclic fatty acid derivatives, metal soaps of the fatty acid derivatives, nitrogen-containing derivatives, hydrocarbons, waxes, fats and oils, waxes, lanolin , Sphingophospholipids, phospholipids, phospholipid derivatives, sterols, sapogenins, saponins, sterol esters, lipid complexes, oxyacid esters, polyhydric alcohol fatty acid esters, fatty acid alkanolamides, The biological tissue repair-promoting agent according to claim 1, comprising silicones and / or fluorine-based oils.   Moisturizer, feel improver, surfactant, polymer, thickener, gelling agent, solvent, propellant, antioxidant, reducing agent, oxidizing agent, preservative, antibacterial agent, chelating agent, pH adjuster, Acids, alkalis, powders, inorganic salts, UV absorbers, whitening agents, vitamins, vitamin derivatives, anti-inflammatory agents, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti Aging agent, attractant, astringent, cooling sensation, warming sensation, wound healing promoter, irritation relieving agent, analgesic agent, cell activator, plant extract, animal extract, microbial extract, antipruritic agent, exfoliating agent, keratin It contains a solubilizer, a peeling agent, an antiperspirant, a refreshing agent, an enzyme, a nucleic acid, a fragrance, a pigment, a colorant, a dye, a pigment, and / or water. Drug.   8. The water according to claim 7, wherein the water is normal water, purified water, hard water, soft water, natural water, deep ocean water, electrolytic alkali ion water, electrolytic acid ion water, ion water, and / or cluster water. The biological tissue repair promoting agent described.   The biological tissue repair according to claim 7, wherein the plant extract, the animal extract or the microbial extract is an extract from a plant tissue or an animal tissue, an extract from a microbial tissue, or a microbial product. Promotion drug.   The biological tissue repair-promoting drug according to claim 1, wherein the active ingredient is contained in an amount of 0.0001 to 99.9% by mass.