JP2009039267A - Non-invasive biological information measuring device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To select a light quantity of a laser corresponding to a user's biological state in a non-invasive biological information measuring device for calibrating a blood glucose level measured with a non-invasive blood glucose measuring device using a blood glucose level measured with an invasive blood glucose measuring device In addition, a non-invasive biological information measuring device with low power consumption is provided.
A non-invasive biological information measuring apparatus for calibrating a blood glucose level measured by a non-invasive blood glucose measuring apparatus using a blood glucose level measured by an invasive blood glucose measuring apparatus. Is measured with multiple light quantities, and multiple estimated blood glucose levels are calculated from the multiple feature quantities calculated with the respective light quantities and the blood glucose levels measured with the invasive blood glucose measurement device. At the end of the calibration period, invasive blood glucose measurement is performed. It is possible to provide a noninvasive living body information measuring apparatus that compares a blood glucose level measured by the apparatus with a plurality of estimated blood glucose levels and performs measurement in a normal measurement period with the light amount of the estimated blood glucose level that is the closest result.
[Selection] Figure 2

Description

  The present invention relates to a noninvasive living body information measuring apparatus capable of measuring living body information without invading a living body, and more specifically, based on a blood glucose level measured noninvasively during a calibration period, The present invention relates to a non-invasive biological information measuring device that can be selected.

  The number of patients with diabetes, a typical lifestyle-related disease, is increasing worldwide. Diabetic patients require routine glycemic control to reduce complications from diabetes and improve the quality of life of patients. Therefore, patients must measure blood glucose regularly every day under the guidance of a doctor.

  As a typical method for measuring a blood glucose level, there is an invasive blood glucose measuring device that measures blood glucose level by collecting blood by inserting a patient's finger. The invasive blood glucose measurement device is troublesome and painful when blood is collected by puncturing a finger, and there is a risk of infection, etc., so there is no need to collect blood, and blood glucose measurement is not required. A device has already been proposed.

  As an example of this non-invasive blood glucose measurement device, a “biological measurement system” using a photoacoustic effect has been proposed (for example, Patent Document 1).

  A “biological measurement system” using a photoacoustic effect irradiates a part of a living body, such as a fingertip, from the biological measurement system with light having a wavelength absorbed by glucose. The light is focused on a relatively small focal area. In general, the collected light is absorbed by glucose and converted into kinetic energy in the tissue in the region adjacent to the focal region.

The kinetic energy converted in the tissue increases the temperature and pressure of the absorbing tissue region and generates sound waves. This sound wave is hereinafter referred to as “photoacoustic wave signal”. The photoacoustic wave signal is emitted from the absorbing tissue region and detected by an acoustic sensor included in the biological measurement system. The acoustic sensor is mounted in contact with the living body surface. The intensity of the photoacoustic wave signal is a function of the amount of glucose in the absorbing tissue region, and the intensity measured by the sensor is used to examine the blood glucose level.
Special table 2001-526557 gazette

  However, in the technique described in Patent Document 1, the photoacoustic wave obtained from a living body is very weak, and the output of the laser that can obtain a signal that can estimate the feature amount from the weak signal change is output from the blood vessel. It was used regardless of the user's biological condition such as the blood sugar concentration. For this reason, a user who can obtain a sufficient signal at a low output requires a large amount of power to use a high output laser, and is unsuitable as a portable device.

  Moreover, in the technique described in the said patent document 1, in order to minimize the influence of noise and the influence of a body motion, a measurement is performed in multiple times and a series of measurement results are averaged. Therefore, there is a problem that not only power consumption but also measurement time increases.

  SUMMARY OF THE INVENTION An object of the present invention is to solve the conventional problems, and to provide a non-invasive living body information measuring apparatus that selects a light amount of a laser according to a user's living state and has low power consumption and a short measuring time.

  In order to solve the conventional problems, the non-invasive living body information measuring device of the present invention uses a blood glucose level measured by an invasive blood glucose measuring device to calibrate the blood glucose level measured by the non-invasive blood glucose measuring device. In the biological information measuring device, from at least one light source, control means for controlling the light amount and lighting timing of the light source and activation of each means described later, a biological information sensor for measuring biological information for a predetermined time, and the biological information sensor Amplifying means for amplifying the output signal, A / D converting means for A / D converting the amplified signal, storage means for storing the A / D converted digital data, and storage means From the feature amount detection means that analyzes the digital data that is calculated to calculate the feature amount of the biological information, the feature amount calculated by the feature amount detection means, and the blood glucose level measured by the invasive blood glucose measurement device, Blood glucose level estimating means for obtaining a constant blood glucose level, performing measurement with the non-invasive blood glucose measurement device with a plurality of light amounts during a calibration period, and a plurality of the feature amounts calculated with the respective light amounts, and the invasive type A plurality of estimated blood glucose levels are calculated from the blood glucose levels measured by the blood glucose measuring device, and at the end of the calibration period, the blood glucose levels measured by the invasive blood glucose measuring device and the plurality of estimated blood glucose levels are compared, and the closest result is obtained. The measurement of the normal measurement period is performed with the light amount of the estimated blood sugar level.

  Further, in the non-invasive living body information measuring device, the blood glucose level estimating means calculates an average error by comparing the blood glucose level measured by the invasive blood glucose measuring device with the plurality of estimated blood glucose levels, and calculating the average error Is provided with light quantity selection means for detecting the smallest light quantity that is equal to or less than a preset threshold value.

  Further, in the non-invasive living body information measuring apparatus, the light amount selecting means includes a register which can be written from the outside, and the threshold value can be changed according to the value of the register.

  Furthermore, in the noninvasive living body information measuring apparatus, the control means includes a light quantity changing means, and controls the light quantity according to the light quantity instruction signal output from the blood sugar level estimating means.

  Further, in the non-invasive living body information measuring device, the light amount changing means includes at least one first register group writable from the outside, and can change a light amount value according to the light amount instruction signal. It is characterized by.

  Further, in the non-invasive living body information measuring apparatus, the control means includes a light quantity periodic confirmation means, and the light quantity is set in advance at a predetermined period for the light source during the normal measurement period. It is characterized by changing to a value and outputting.

  Furthermore, in the noninvasive living body information measuring device, the light quantity periodic confirmation means includes a register that can be written from the outside, and the period for changing the light quantity can be changed according to the value of the register. Is.

  Furthermore, in the non-invasive living body information measuring device, the light quantity periodic confirmation means includes a register which can be written from the outside, and the value of the light quantity can be changed by the value of the register. is there.

  Further, in the non-invasive living body information measuring apparatus, the blood glucose level estimation means includes a light quantity appropriateness confirmation means, and is changed by the estimated blood glucose level measured by the light quantity changed by the light quantity regular confirmation means and the light quantity regular confirmation means. When an error is calculated by comparing the estimated blood glucose level measured with the light amount set before the determination, the error is less than or equal to a preset threshold, and the error is less than or equal to a preset threshold Is characterized in that a light quantity restoration signal is output to the control means so as to return the light quantity set before the light quantity periodic confirmation means is changed.

  Furthermore, in the non-invasive living body information measuring device, the light quantity appropriateness confirmation means includes a register which can be written from the outside, and the threshold value can be changed according to the value of the register.

  Further, the noninvasive biological information measuring device of the present invention is a noninvasive biological information measuring device that calibrates a blood glucose level measured by a noninvasive blood glucose measuring device using a blood glucose level measured by an invasive blood glucose measuring device. One light source, control means for controlling the light quantity and lighting timing of the light source and activation of each means described later, a biological information sensor for measuring biological information for a predetermined time, and amplification for amplifying an output signal from the biological information sensor Means, A / D conversion means for A / D converting the amplified signal, storage means for storing the A / D converted digital data, lighting the light source, and storing the digital data in the storage means A series of operations until storage is repeated a predetermined number of times, the digital data for a predetermined number of times stored in the storage means is averaged, and the averaged data is analyzed to analyze biometric information. A feature amount detecting means for calculating a collected amount, a feature amount calculated by the feature amount detecting means, and a blood glucose level estimating means for obtaining an estimated blood glucose level from a blood glucose level measured by the invasive blood glucose measuring device, In the calibration period, the series of operations in the non-invasive blood glucose measurement device is performed at a plurality of repetitions, and the plurality of feature amounts calculated at the respective repetitions and the blood glucose level measured by the invasive blood glucose measurement device are used. A plurality of estimated blood glucose levels are calculated, and at the end of the calibration period, the blood glucose level measured by the invasive blood glucose measuring device is compared with the plurality of estimated blood glucose levels, and the number of repetitions of the estimated blood glucose level that is the closest result is The measurement period is measured.

  Further, in the non-invasive living body information measuring device, the blood glucose level estimating means calculates an average error by comparing the blood glucose level measured by the invasive blood glucose measuring device with the plurality of estimated blood glucose levels, and calculating the average error Is provided with repetition number selection means for detecting the smallest number of repetitions that is equal to or less than a preset threshold value.

  Furthermore, in the non-invasive living body information measuring apparatus, the repetition number selecting means includes a register which can be written from the outside, and the threshold value can be changed according to the value of the register.

  Furthermore, in the noninvasive living body information measuring apparatus, the control means includes a repetition number changing means, and controls the number of repetitions according to a repetition number instruction signal output from the blood sugar level estimation means. It is.

  Further, in the non-invasive living body information measuring apparatus, the repetition number changing means may include at least one first register group writable from the outside, and change the value of the repetition number according to the repetition number instruction signal. It is characterized by being able to.

  Further, in the non-invasive living body information measuring apparatus, the control means includes a repeat count periodic confirmation means, and in the normal measurement period, the lighting timing is set to a preset value at a preset period with respect to the light source. It is characterized in that the number of repetitions is changed and output.

  Furthermore, in the noninvasive living body information measuring device, the repetition number periodic confirmation means includes a register which can be written from the outside, and can change a cycle for changing the number of repetitions according to a value of the register. It is what.

  Furthermore, in the noninvasive living body information measuring apparatus, the repetition number periodic confirmation means includes a register that can be written from the outside, and the value of the number of repetitions can be changed according to the value of the register. Is.

  Furthermore, in the non-invasive living body information measuring apparatus, the blood glucose level estimation means includes a repetition number appropriateness confirmation means, and the estimated blood sugar level measured by the repetition number changed by the repetition number periodic confirmation part and the repetition number periodic confirmation An error is calculated by comparing the estimated blood glucose level measured at the number of repetitions set before the change by means, it is determined whether the error is less than a preset threshold, and the error is set in advance If it is less than or equal to the threshold value, a repeat count restoration signal is output to the control means so as to return to the repeat count set before being changed by the repeat count periodic confirmation means. is there.

  Furthermore, in the non-invasive living body information measuring apparatus, the repeat number appropriateness checking means includes a register which can be written from the outside, and the threshold value can be changed according to a value of the register. .

  According to the noninvasive living body information measuring device of the present invention, it is possible to realize a device with low power consumption and a short measuring time, and it is possible to improve the continuous measuring time of a portable device.

  Embodiments of the noninvasive living body information measuring apparatus of the present invention will be described below in detail with reference to the drawings.

(Embodiment 1)
In the first embodiment of the present invention, it is assumed that the noninvasive biological information measuring device is a noninvasive blood glucose measuring device 101.

  FIG. 1 is a diagram showing a system configuration according to Embodiment 1 of the present invention. In FIG. 1, 101 is a noninvasive blood glucose measuring device, 102 is the surface of a living body, 103 is light, 104 is a blood vessel, and 105 is a photoacoustic wave signal. (A) is an activation signal 83, (b) is a lighting timing 82, (c) is a photoacoustic wave signal 105, (d) is an end signal 84, and (e) is an estimated blood sugar level calculation timing.

  The noninvasive blood glucose measuring device 101 is mounted so as to be in contact with the surface 102 of the living body, and the light 103 irradiated by the noninvasive blood glucose measuring device 101 is incident on the living body. The light 103 propagates in the living body and is absorbed by a substance that can estimate the blood glucose level in the blood vessel 104, and a photoacoustic wave signal 105 is generated. The noninvasive blood glucose measuring device 101 detects a photoacoustic wave signal 105 generated by a substance that can estimate the blood glucose level in the blood vessel 104, and estimates a blood glucose level that is a characteristic amount of biological information.

  FIG. 2 is a diagram showing a block configuration of the noninvasive blood glucose measurement device 101 according to Embodiment 1 of the present invention. In FIG. 2, 101 is a non-invasive blood glucose measurement device, 201 is a light source, 202 is a biological information sensor, 203 is an amplification means, 204 is an A / D conversion means, 205 is a storage means, 206 is a feature amount detection means, 207 is A blood sugar level estimating means 208 is a control means.

  The light source 201 includes at least one light source, and emits light 103 having a wavelength that is absorbed by a substance capable of estimating a blood glucose level in the blood vessel 104. The control unit 208 includes a light amount change unit 281 and a light amount periodic confirmation unit 285, changes the light amount 81 of the light source 201 according to the light amount instruction signal 71, controls the lighting timing 82 of the light source 201, and further amplifies the unit 203. A start signal 83 is output to the A / D conversion means 204, and an end signal 84 is output to the amplification means 203, the A / D conversion means 204, the feature amount detection means 206, and the blood glucose level estimation means 207.

  The light amount changing unit 281 outputs the light amount 81 to the light source 201 in accordance with the light amount instruction signal 71 output from the blood sugar level estimating unit 207.

  The regular light quantity confirmation means 285 changes the light quantity 81 to a value preset in the confirmation light quantity register 287 and outputs it to the light source 201 at a period preset in the confirmation period register A 286 for the light source 201. To do.

  The biological information sensor 202 converts the photoacoustic wave signal 105 into the voltage signal 21. The amplifying unit 203 detects the voltage signal 21 based on the activation signal 83 from the control unit 208 and generates an amplified signal 31. The A / D conversion unit 204 converts the amplified signal 31 into sampling data 41 based on the activation signal 83 from the control unit 208. The storage unit 205 is an area for storing the sampling data 41, written by the A / D conversion unit 204, and read by the feature amount detection unit 206. The feature amount detection unit 206 analyzes the stored data 51 and calculates the feature amount 61 of the biological information.

  The blood sugar level estimation means 207 is composed of a light quantity selection means 271 and a light quantity appropriateness confirmation means 273, and the blood sugar level change amount measured by an invasive blood glucose measurement device (not shown) is preset in the calibration blood sugar threshold register 275. Calibration data is calculated when the threshold value is exceeded, and an estimated blood glucose level 72 is obtained from the feature amount 61 calculated by the feature amount detection means 206 and the blood glucose level measured by the invasive blood glucose measurement device based on the calculated calibration data. Output to the outside.

  The light amount selection means 271 compares the blood glucose level measured by the invasive blood glucose measurement device with a plurality of estimated blood glucose levels, calculates the average of the errors, and the average of the errors is equal to or less than a threshold value set in advance in the estimation error register A272. And the light quantity of the smallest estimated blood glucose level is detected, and the light quantity instruction signal 71 is output.

  The light quantity appropriateness confirmation means 273 compares the estimated blood sugar level measured with the light quantity changed by the light quantity periodic confirmation means 285 and the estimated blood sugar level measured with the light quantity set before being changed by the light quantity regular confirmation means 285. The error is calculated, and it is determined whether the error is less than or equal to a threshold value preset in the appropriate error register A 274. If the error is less than or equal to the threshold value, the control unit 208 is changed by the light quantity periodic confirmation unit 285. A light quantity restoration signal 73 is output so as to return to the previously set light quantity.

  FIG. 3 is a diagram in which the estimated blood glucose level 72 of the noninvasive blood glucose measurement device 101 according to Embodiment 1 of the present invention is plotted on the time axis. 3, (a) is an estimated blood glucose level 72, (b) is an enlarged view of the estimated blood glucose level 72 (time 10 minutes to time 20 minutes and time 90 minutes to time 100 minutes), and (c) is a light quantity 81. .

  FIG. 4 is an enlarged view from time 0 to 20 minutes in which the blood glucose level and the estimated blood glucose level 72 of the invasive blood glucose measurement device 101 and the non-invasive blood glucose measurement device 101 according to Embodiment 1 of the present invention are plotted on the time axis. . In FIG. 4, 401 is an approximate curve calculated based on the approximate expression.

  Hereinafter, the operation when the noninvasive blood glucose measuring device 101 performs continuous blood glucose measurement will be described with reference to FIGS. 1, 2, and 3.

  In the first embodiment of the present invention, the measurement with the invasive blood glucose measurement device is performed at 10-minute intervals, and the measurement with the non-invasive blood glucose measurement device 101 is performed by the control means 208 by the amplification means 203 and the A / D conversion means 204. The interval from the output of the activation signal 83 to the blood glucose level estimation means 207 calculating the estimated blood glucose level 72 and outputting it to the outside is defined as a measurement basic cycle, and is repeated at intervals of 6 minutes.

However, in order to minimize the error of the estimated blood glucose level 72 due to body movement such as breathing and pulse and the influence of external noise, the above measurement basic cycle is repeatedly operated a specified number of times at a period of about 10 μs to 100 ms, and the measurement basic cycle There is also a method of calculating the estimated blood glucose level 72. (Details are shown in Embodiment 2.)
Here, as an initial value of a register writable from the outside,
20 μJ as the minimum light amount value (minimum light amount register 282) of the light amount changing means 281
20 μJ as an increase amount (increase light amount register 283) of the light amount 81 of the light amount changing means 281
100 μJ as the maximum light amount value (maximum light amount register 284) of the light amount changing means 281,
10 mg / dl as an average threshold value (estimation error register A 272) of an error between the blood glucose level measured by the invasive blood glucose measurement device of the light quantity selection means 271 and the estimated blood glucose level 72;
30 minutes as the output period (confirmation period register A286) of the lighting timing 82 of the light quantity periodic confirmation means 285,
As the light amount 81 of the light amount periodic confirmation means 285 (confirmation light amount register 287), 100 μJ,
An error between the estimated blood glucose level measured with the light amount changed by the light amount periodic confirmation unit 285 of the light amount appropriateness confirmation unit 273 and the estimated blood glucose level measured with the light amount set before being changed by the light amount periodic confirmation unit 285 (appropriate 3 mg / dl as error register A274)
70 mg / dl is set as the blood glucose level change amount (calibration blood glucose threshold register 275) of the invasive blood glucose measuring device necessary for calculating the calibration data.

  First, at time 0 minutes, when a blood collection switch (not shown) provided in the invasive blood glucose measurement device is pressed by the user, measurement of a blood glucose level accompanying blood collection is started. Blood is collected from the living body by a blood collecting means such as a puncture needle, and the blood glucose level is measured.

  The blood glucose level at this time is 70 mg / dl.

  The user transmits blood glucose measurement information 91 (time 0 minutes: 70 mg / dl) such as a blood glucose level measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101. Blood glucose measurement information 91 is input by an information input means (not shown).

  The input blood glucose measurement information 91 is stored in the storage unit 205.

  Here, the blood glucose measurement information 91 measured by the invasive blood glucose measurement device is input to the non-invasive blood glucose measurement device 101 by the user, but the invasive blood glucose measurement device automatically transfers to the non-invasive blood glucose measurement device 101. May be transferred.

  As shown in FIG. 1, the non-invasive blood glucose measuring device 101 is attached to the surface 102 of a living body such as an arm, and then the blood glucose level measurement start switch (not shown) provided on the non-invasive blood glucose measuring device 101 by the user. Is activated, the control unit 208 outputs an activation signal 83 to the amplification unit 203 and the A / D conversion unit 204, and the light amount 81 of the light source 201 is turned on at the timing when the amplification unit 203 and the A / D conversion unit 204 enter a stable operation. The timing 82 is controlled and the light source 201 is turned on.

  At this time, since 20 μJ is set in the minimum light amount register 282 included in the light amount changing unit 281, 20 μJ is output as the light amount 81 to the light source 201.

  Here, the invasive blood glucose measurement device and the noninvasive blood glucose measurement device 101 have been described as being started by the user simultaneously pressing the blood collection switch and the measurement start switch, but the measurement is performed at the same time. The non-invasive blood glucose measurement device 101 may be activated from the invasive blood glucose measurement device and measurement may be started. Alternatively, the invasive blood glucose measurement device may be activated from the non-invasive blood glucose measurement device 101 to start measurement. May be.

  The light 103 from the light source 201 propagates in the living body and is absorbed by a substance capable of estimating the blood glucose level in the blood vessel 104 to generate a photoacoustic wave signal 105.

  The biological information sensor 202 converts the pressure of the photoacoustic wave signal 105 into the voltage signal 21. The amplification means 203 receives the activation signal 83 from the control means 208, amplifies the voltage signal 21 converted by the biological information sensor 202 with a preset gain, and outputs the amplified signal 31 to the A / D conversion means 204. To do.

  Here, the start signal 83 and the end signal 84 are input to the amplifying means 203 because the operation of an element such as an operational amplifier, which is a component of the amplifying means 203, is performed only at the timing when the photoacoustic wave signal 105 is generated. This is for the purpose of reducing the power consumption of the amplifying means 203 for enabling. Accordingly, even if these signals are not input, it is possible to perform the same operation.

  The A / D conversion unit 204 receives the activation signal 83 from the control unit 208, performs analog-digital conversion on the amplified signal 31 output from the amplification unit 203 at a specific interval, and writes the sampling data 41 in the storage unit 205.

  Here, the reason why the start signal 83 and the end signal 84 are input to the A / D conversion means 204 is AD that is a component of the A / D conversion means 204 only at the timing when the photoacoustic wave signal 105 is generated. This is for enabling the operation of an element such as a converter, and for the purpose of reducing the power consumption of the A / D conversion means 204. Accordingly, even if these signals are not input, it is possible to perform the same operation.

  The feature amount detection unit 206 receives the end signal 84 from the control unit 208, reads the stored data 51 stored in the storage unit 205, analyzes it, calculates the feature amount 61 of the biological information, and stores it.

  Here, the feature data 61 is calculated by writing the sampling data 41 of the A / D conversion means 204 once into the storage means 205, reading it by the feature value detection means 206, and analyzing it, but the feature value detection means 206. It is obvious that the feature quantity 61 can be calculated by directly receiving the sampling data 41 from the A / D conversion means 204.

  When the light source 201 is turned on with the light amount 81 of 20 μJ and the series of operations for storing the feature amount 61 is completed, the light amount changing unit 281 adds 20 μJ set in the increased light amount register 283 to the current light amount 81 and adds It is compared whether or not the light amount 81 (40 μJ) is larger than the maximum light amount (100 μJ) set in the maximum light amount register 284.

  Since the added light amount 81 does not exceed the maximum light amount register 284, the control unit 208 controls the light amount 81 of 40 μJ and the lighting timing 82 to turn on the light source 201.

  As in the case of the light amount 81 of 20 μJ, the light source 201 is turned on with the light amount 81 of 40 μJ, and a series of operations for storing the feature amount 61 is performed. Is added to the current light amount 81, and whether the added light amount 81 (60 μJ) is larger than the maximum light amount (100 μJ) set in the maximum light amount register 284 is compared.

  Since the added light quantity 81 does not exceed the maximum light quantity register 284, the control unit 208 controls the 60 μJ light quantity 81 and the lighting timing 82 to turn on the light source 201.

  As in the case of the light amount 81 of 20 μJ, the light source 201 is turned on with the light amount 81 of 60 μJ, a series of operations for storing the feature amount 61 is performed, and when the series of operations is completed, the light amount changing unit 281 Is added to the current light amount 81, and whether the added light amount 81 (80 μJ) is larger than the maximum light amount (100 μJ) set in the maximum light amount register 284 is compared.

  Since the added light amount 81 does not exceed the maximum light amount register 284, the control unit 208 controls the light amount 81 of 80 μJ and the lighting timing 82 to turn on the light source 201.

  As in the case of the light amount 81 of 20 μJ, the light source 201 is turned on with the light amount 81 of 80 μJ, and a series of operations for storing the feature amount 61 is performed. Is added to the current light amount 81, and whether the added light amount 81 (100 μJ) is larger than the maximum light amount (100 μJ) set in the maximum light amount register 284 is compared.

  Since the added light amount 81 does not exceed the maximum light amount register 284, the control unit 208 controls the light amount 81 of 100 μJ and the lighting timing 82 to turn on the light source 201.

  As in the case of the light amount 81 of 20 μJ, the light source 201 is turned on with the light amount 81 of 100 μJ, and a series of operations for storing the feature amount 61 is performed. The set 20 μJ is added to the current light amount 81, and whether the added light amount 81 (120 μJ) is larger than the maximum light amount (100 μJ) set in the maximum light amount register 284 is compared.

  Since the added light amount 81 exceeds the maximum light amount register 284, the light amount changing means 281 returns the light amount 81 to the minimum light amount (20 μJ) set in the minimum light amount register 282, and the next noninvasive blood glucose measuring device 101. Wait until the measurement timing (6 minutes).

  Here, the light amount 81 is changed from the minimum light amount (20 μJ) to the maximum light amount (100 μJ) according to the register group (minimum light amount register 282, increase light amount register 283, and maximum light amount register 284) provided in the light amount changing means 281. However, a method of changing the light amount 81 by providing a register group for setting a plurality of light amounts may be used.

  When the time is 6 minutes, the measurement with the non-invasive blood glucose measurement device 101 is performed at intervals of 6 minutes. Perform a series of actions to save.

  When the measurement with the light amount 81 of 100 μJ is completed, the light amount changing means 281 returns the light amount 81 to the minimum light amount (20 μJ) set in the minimum light amount register 282, and the next measurement timing (non-invasive blood glucose measuring device 101) 12 minutes).

  When the time is 10 minutes, as in the case of time 0 minutes, when the user presses a blood collection switch included in the invasive blood glucose measurement device, the measurement is started, and measurement is performed with the invasive blood glucose measurement device. The measurement method is the same as that at time 0 minutes.

  The blood glucose level at this time is 82 mg / dl. The user inputs blood glucose measurement information 91 (time 10 minutes: 82 mg / dl) measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101.

  The input blood glucose measurement information 91 is stored in the storage unit 205 and also input to the blood glucose level estimation unit 207, and is compared with the blood glucose level (70 mg / dl) at time 0 to calculate a change amount of 12 mg / dl. Since the calculated change amount is smaller than the threshold value 70 mg / dl set in the calibration blood glucose threshold register 275, the measurement with the invasive blood glucose measurement device is continued.

  When the time is 12 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 20 μJ from 20 μJ to 100 μJ and storing the feature quantity 61 as in the case of time 6 minutes.

  When the measurement with the light amount 81 of 100 μJ is completed, the light amount changing means 281 returns the light amount 81 to the minimum light amount (20 μJ) set in the minimum light amount register 282, and the next measurement timing (non-invasive blood glucose measuring device 101) 18 minutes).

  When the time is 18 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 20 μJ from 20 μJ to 100 μJ and storing the feature quantity 61 as in the case of time 6 minutes.

  When the measurement with the light amount 81 of 100 μJ is completed, the light amount changing means 281 returns the light amount 81 to the minimum light amount (20 μJ) set in the minimum light amount register 282, and the next measurement timing (non-invasive blood glucose measuring device 101) 24 minutes).

  When the time is 20 minutes, as in the case of time 0 minutes, when the user presses a blood collection switch provided in the invasive blood glucose measurement device, the measurement is started, and measurement is performed with the invasive blood glucose measurement device. The measurement method is the same as that at time 0 minutes.

  The blood glucose level at this time is 100 mg / dl. The user inputs blood glucose measurement information 91 (time 20 minutes: 100 mg / dl) measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101.

  The input blood glucose measurement information 91 is stored in the storage unit 205 and is also input to the blood glucose level estimation unit 207 and is compared with the blood glucose level (70 mg / dl) at time 0 to calculate a change amount of 30 mg / dl. Since the calculated change amount is smaller than the threshold value 70 mg / dl set in the calibration blood glucose threshold register 275, the measurement with the invasive blood glucose measurement device is continued.

  When the time is 24 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations to turn on the light source 201 at intervals of 20 μJ from 20 μJ to 100 μJ and store the feature value 61, as in the case of time 6 minutes.

  When the measurement with the light amount 81 of 100 μJ is completed, the light amount changing means 281 returns the light amount 81 to the minimum light amount (20 μJ) set in the minimum light amount register 282, and the next measurement timing (non-invasive blood glucose measuring device 101) 30 minutes).

  When the time is 30 minutes, as in the case of time 0 minutes, when the user presses a blood collection switch provided in the invasive blood glucose measurement device, the measurement is started, and measurement is performed with the invasive blood glucose measurement device. The measurement method is the same as that at time 0 minutes.

  The blood glucose level at this time is 118 mg / dl. The user inputs blood glucose measurement information 91 (time 30 minutes: 118 mg / dl) measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101.

  The input blood glucose measurement information 91 is stored in the storage unit 205 and also input to the blood glucose level estimation unit 207, and is compared with the blood glucose level (70 mg / dl) at time 0 to calculate a change amount of 48 mg / dl. Since the calculated change amount is smaller than the threshold value 70 mg / dl set in the calibration blood glucose threshold register 275, the measurement with the invasive blood glucose measurement device is continued.

  The non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 20 μJ from 20 μJ to 100 μJ and storing the feature quantity 61 as in the case of 6 minutes.

  When the measurement with the light amount 81 of 100 μJ is completed, the light amount changing means 281 returns the light amount 81 to the minimum light amount (20 μJ) set in the minimum light amount register 282, and the next measurement timing (non-invasive blood glucose measuring device 101) 36 minutes).

  When the time is 36 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 20 μJ from 20 μJ to 100 μJ and storing the feature quantity 61 as in the case of time 6 minutes.

  When the measurement with the light amount 81 of 100 μJ is completed, the light amount changing means 281 returns the light amount 81 to the minimum light amount (20 μJ) set in the minimum light amount register 282, and the next measurement timing (non-invasive blood glucose measuring device 101) 42 minutes).

  When the time is 40 minutes, as in the case of time 0 minutes, when the user presses a blood collection switch provided in the invasive blood glucose measurement device, the measurement is started, and measurement is performed with the invasive blood glucose measurement device. The measurement method is the same as that at time 0 minutes.

  The blood glucose level at this time is 125 mg / dl. The user inputs blood glucose measurement information 91 (time 40 minutes: 125 mg / dl) measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101.

  The input blood glucose measurement information 91 is stored in the storage unit 205 and also input to the blood glucose level estimation unit 207, and is compared with the blood glucose level (70 mg / dl) at time 0 to calculate a change amount of 60 mg / dl. Since the calculated change amount is smaller than the threshold value 70 mg / dl set in the calibration blood glucose threshold register 275, the measurement with the invasive blood glucose measurement device is continued.

  When the time is 42 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 20 μJ from 20 μJ to 100 μJ and storing the feature quantity 61 as in the case of time 6 minutes.

  When the measurement with the light amount 81 of 100 μJ is completed, the light amount changing means 281 returns the light amount 81 to the minimum light amount (20 μJ) set in the minimum light amount register 282, and the next measurement timing (non-invasive blood glucose measuring device 101) 48 minutes).

  At time 48 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 20 μJ from 20 μJ to 100 μJ, and storing the feature quantity 61, as in the case of time 6 minutes.

  When the measurement with the light amount 81 of 100 μJ is completed, the light amount changing means 281 returns the light amount 81 to the minimum light amount (20 μJ) set in the minimum light amount register 282, and the next measurement timing (non-invasive blood glucose measuring device 101) 54 minutes).

  When the time is 50 minutes, as in the case of time 0 minutes, when the user presses a blood collection switch provided in the invasive blood glucose measurement device, the measurement is started, and measurement is performed with the invasive blood glucose measurement device. The measurement method is the same as that at time 0 minutes.

  The blood glucose level at this time is 138 mg / dl. The user inputs blood glucose measurement information 91 (time 50 minutes: 138 mg / dl) measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101.

  The input blood glucose measurement information 91 is stored in the storage unit 205 and also input to the blood glucose level estimation unit 207, and is compared with the blood glucose level (70 mg / dl) at time 0 to calculate a change amount of 68 mg / dl. Since the calculated change amount is smaller than the threshold value 70 mg / dl set in the calibration blood glucose threshold register 275, the measurement with the invasive blood glucose measurement device is continued.

  When the time is 54 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 20 μJ from 20 μJ to 100 μJ and storing the feature quantity 61 as in the case of time 6 minutes.

  When the measurement with the light amount 81 of 100 μJ is completed, the light amount changing means 281 returns the light amount 81 to the minimum light amount (20 μJ) set in the minimum light amount register 282, and the next measurement timing (non-invasive blood glucose measuring device 101) 60 minutes).

  When the time is 60 minutes, as in the case of time 0 minutes, when the user presses the blood collection switch included in the invasive blood glucose measurement device, the measurement is started, and measurement is performed with the invasive blood glucose measurement device. The measurement method is the same as that at time 0 minutes.

  The blood glucose level at this time is 142 mg / dl. The user inputs blood glucose measurement information 91 (time 60 minutes: 142 mg / dl) measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101.

  The input blood glucose measurement information 91 is stored in the storage unit 205 and also input to the blood glucose level estimation unit 207, and is compared with the blood glucose level (70 mg / dl) at time 0 to calculate a change amount of 72 mg / dl. Since the calculated change amount is not less than the threshold value 70 mg / dl set in the calibration blood glucose threshold value register 275, seven data of the invasive blood glucose measurement device measured so far (time 0 minutes: 70 mg / dl, time 10 minutes: 82 mg / dl, time 20 minutes: 100 mg / dl, time 30 minutes: 118 mg / dl, time 40 minutes: 125 mg / dl, time 50 minutes: 138 mg / dl, time 60 minutes: 142 mg / dl) The approximate curve 401 is calculated from the calculated approximate expression. Furthermore, the approximate blood glucose level at the timing measured by the noninvasive blood glucose measurement device 101 is calculated from the approximate curve 401, and calibration is performed for each light quantity based on the approximate blood glucose level and the feature quantity 61 of the noninvasive blood glucose measurement device 101 for each light quantity. Calculate the data.

  Based on the calculated calibration data, an estimated blood glucose level 72 for each light amount from time 0 minutes to time 60 minutes is obtained.

When the estimated blood glucose level 72 at each measurement time is calculated based on the calibration data,
When time is 0 minutes
The estimated blood glucose level 72 with a light intensity of 20 μJ is 68 mg / dl,
The estimated blood glucose level 72 with a light intensity of 40 μJ is 69 mg / dl,
The estimated blood glucose level 72 with a light intensity of 60 μJ is 70 mg / dl,
The estimated blood glucose level 72 with a light intensity of 80 μJ is 70 mg / dl,
The estimated blood glucose level 72 with a light intensity of 100 μJ is 70 mg / dl.

At 6 minutes
The estimated blood glucose level 72 with a light intensity of 20 μJ is 75 mg / dl,
The estimated blood glucose level 72 with a light intensity of 40 μJ is 76 mg / dl,
The estimated blood glucose level 72 with a light intensity of 60 μJ is 78 mg / dl,
The estimated blood glucose level 72 with a light intensity of 80 μJ is 78 mg / dl,
The estimated blood glucose level 72 with a light intensity of 100 μJ is 78 mg / dl.

At 12 minutes
The estimated blood glucose level 72 with a light intensity of 20 μJ is 79 mg / dl,
The estimated blood glucose level 72 with a light intensity of 40 μJ is 80 mg / dl,
The estimated blood glucose level 72 with a light intensity of 60 μJ is 83 mg / dl,
The estimated blood glucose level 72 with a light intensity of 80 μJ is 85 mg / dl,
The estimated blood glucose level 72 with a light intensity of 100 μJ is 87 mg / dl.

At 18 minutes
The estimated blood glucose level 72 with a light intensity of 20 μJ is 80 mg / dl,
The estimated blood glucose level 72 with a light intensity of 40 μJ is 82 mg / dl,
Estimated blood glucose level 72 with a light intensity of 60 μJ is 85 mg / dl,
The estimated blood glucose level 72 with a light intensity of 80 μJ is 88 mg / dl,
The estimated blood glucose level 72 with a light intensity of 100 μJ is 92 mg / dl.

At 24 hours
The estimated blood glucose level 72 with a light intensity of 20 μJ is 82 mg / dl,
The estimated blood glucose level 72 with a light intensity of 40 μJ is 83 mg / dl,
The estimated blood glucose level 72 with a light intensity of 60 μJ is 92 mg / dl,
The estimated blood glucose level 72 with a light intensity of 80 μJ is 105 mg / dl,
The estimated blood glucose level 72 with a light intensity of 100 μJ is 108 mg / dl.

At 30 minutes
The estimated blood glucose level 72 with a light intensity of 20 μJ is 83 mg / dl,
The estimated blood glucose level 72 with a light intensity of 40 μJ is 85 mg / dl,
The estimated blood glucose level 72 with a light intensity of 60 μJ is 98 mg / dl,
The estimated blood glucose level 72 with a light intensity of 80 μJ is 113 mg / dl,
The estimated blood glucose level 72 with a light intensity of 100 μJ is 115 mg / dl.

At 36 minutes
The estimated blood glucose level 72 with a light intensity of 20 μJ is 83 mg / dl,
The estimated blood glucose level 72 with a light intensity of 40 μJ is 88 mg / dl,
The estimated blood glucose level 72 with a light intensity of 60 μJ is 105 mg / dl,
The estimated blood glucose level 72 with a light intensity of 80 μJ is 117 mg / dl,
The estimated blood glucose level 72 with a light intensity of 100 μJ is 119 mg / dl.

At 42 minutes
The estimated blood glucose level 72 with a light intensity of 20 μJ is 82 mg / dl,
The estimated blood glucose level 72 with a light intensity of 40 μJ is 90 mg / dl,
The estimated blood glucose level 72 with a light intensity of 60 μJ is 110 mg / dl,
The estimated blood glucose level 72 with a light intensity of 80 μJ is 128 mg / dl,
The estimated blood glucose level 72 with a light amount of 100 μJ is 129 mg / dl.

At 48 minutes
The estimated blood glucose level 72 with a light intensity of 20 μJ is 84 mg / dl,
The estimated blood glucose level 72 with a light intensity of 40 μJ is 92 mg / dl,
The estimated blood glucose level 72 with a light intensity of 60 μJ is 115 mg / dl,
The estimated blood glucose level 72 with a light intensity of 80 μJ is 133 mg / dl,
The estimated blood glucose level 72 with a light intensity of 100 μJ is 134 mg / dl.

At 54 minutes
The estimated blood glucose level 72 with a light intensity of 20 μJ is 85 mg / dl,
The estimated blood glucose level 72 with a light intensity of 40 μJ is 95 mg / dl,
The estimated blood glucose level 72 with a light intensity of 60 μJ is 123 mg / dl,
The estimated blood glucose level 72 with a light intensity of 80 μJ is 138 mg / dl,
The estimated blood glucose level 72 with a light amount of 100 μJ is 138 mg / dl.

At 60 minutes
The estimated blood glucose level 72 with a light intensity of 20 μJ is 85 mg / dl,
The estimated blood glucose level 72 with a light intensity of 40 μJ is 100 mg / dl,
The estimated blood glucose level 72 with a light intensity of 60 μJ is 133 mg / dl,
The estimated blood glucose level 72 with a light intensity of 80 μJ is 142 mg / dl,
The estimated blood glucose level 72 with a light amount of 100 μJ is 142 mg / dl.

  Next, the light quantity selection means 271 does not measure the estimated blood sugar level 72 of the non-invasive blood sugar measuring device and the blood sugar level of the invasive blood sugar measuring device or the blood sugar level for each light quantity from time 0 minutes to time 60 minutes. Compares the approximate blood glucose level to calculate the error.

When calculating the error at each measurement time,
At time 0 minutes, the blood glucose level of the invasive blood glucose measuring device is 70 mg / dl,
The error from the estimated blood glucose level 72 of 20 μJ is 2 mg / dl,
The error from the estimated blood glucose level 72 of 40 μJ is 1 mg / dl,
The error from the estimated blood glucose level 72 of 60 μJ is 0 mg / dl,
The error from the estimated blood glucose level 72 of 80 μJ is 0 mg / dl,
The error from the estimated blood glucose level 72 of 100 μJ is 0 mg / dl.

At time 6 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 78 mg / dl.
The error from the estimated blood glucose level 72 with a light intensity of 20 μJ is 3 mg / dl,
The error from the estimated blood glucose level 72 of 40 μJ is 2 mg / dl,
The error from the estimated blood glucose level 72 of 60 μJ is 0 mg / dl,
The error from the estimated blood glucose level 72 of 80 μJ is 0 mg / dl,
The error from the estimated blood glucose level 72 of 100 μJ is 0 mg / dl.

When the time is 12 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 89 mg / dl.
The error from the estimated blood glucose level 72 of 20 μJ is 10 mg / dl,
The error from the estimated blood glucose level 72 of 40 μJ is 9 mg / dl,
The error from the estimated blood glucose level 72 of 60 μJ is 6 mg / dl,
The error from the estimated blood glucose level 72 with a light intensity of 80 μJ is 4 mg / dl,
The error from the estimated blood glucose level 72 of 100 μJ is 2 mg / dl.

At time 18 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 98 mg / dl.
The error from the estimated blood glucose level 72 of 20 μJ is 18 mg / dl,
The error from the estimated blood glucose level 72 of 40 μJ is 16 mg / dl,
The error from the estimated blood glucose level 72 of 60 μJ is 13 mg / dl,
The error from the estimated blood glucose level 72 of 80 μJ is 10 mg / dl,
The error from the estimated blood glucose level 72 of 100 μJ is 6 mg / dl.

When the time is 24 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 107 mg / dl.
The error from the estimated blood glucose level 72 of 20 μJ is 25 mg / dl,
The error from the estimated blood glucose level 72 of 40 μJ is 24 mg / dl,
The error from the estimated blood glucose level 72 of 60 μJ is 15 mg / dl,
The error from the estimated blood glucose level 72 of 80 μJ is 2 mg / dl,
The error from the estimated blood glucose level 72 of 100 μJ is 1 mg / dl.

At time 30 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 118 mg / dl.
The error from the estimated blood glucose level 72 of 20 μJ is 35 mg / dl,
The error from the estimated blood glucose level 72 of 40 μJ is 33 mg / dl,
The error from the estimated blood glucose level 72 of 60 μJ is 20 mg / dl,
The error with the estimated blood glucose level 72 of 80 μJ is 5 mg / dl,
The error from the estimated blood glucose level 72 of 100 μJ is 3 mg / dl.

When the time is 36 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 122 mg / dl.
The error from the estimated blood glucose level 72 of 20 μJ is 39 mg / dl,
The error from the estimated blood glucose level 72 of 40 μJ is 37 mg / dl,
The error from the estimated blood glucose level 72 of 60 μJ is 24 mg / dl,
The error from the estimated blood glucose level 72 of 80 μJ is 9 mg / dl,
The error from the estimated blood glucose level 72 of 100 μJ is 7 mg / dl.

At time 42 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 128 mg / dl,
The error from the estimated blood glucose level 72 with a light intensity of 20 μJ is 46 mg / dl,
The error from the estimated blood glucose level 72 of 40 μJ is 38 mg / dl,
The error from the estimated blood glucose level 72 of 60 μJ is 18 mg / dl,
The error from the estimated blood glucose level 72 of 80 μJ is 0 mg / dl,
The error from the estimated blood glucose level 72 of 100 μJ is 1 mg / dl.

At time 48 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 133 mg / dl.
The error from the estimated blood glucose level 72 with a light intensity of 20 μJ is 49 mg / dl,
The error from the estimated blood glucose level 72 of 40 μJ is 41 mg / dl,
The error from the estimated blood glucose level 72 of 60 μJ is 18 mg / dl,
The error from the estimated blood glucose level 72 of 80 μJ is 0 mg / dl,
The error from the estimated blood glucose level 72 of 100 μJ is 1 mg / dl.

At time 54 minutes, the approximate blood glucose level of the invasive blood glucose measurement device is 138 mg / dl,
The error from the estimated blood glucose level 72 of 20 μJ is 53 mg / dl,
The error from the estimated blood glucose level 72 of 40 μJ is 43 mg / dl,
The error from the estimated blood glucose level 72 of 60 μJ is 15 mg / dl,
The error from the estimated blood glucose level 72 of 80 μJ is 0 mg / dl,
The error from the estimated blood glucose level 72 of 100 μJ is 0 mg / dl.

When the time is 60 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 142 mg / dl.
The error from the estimated blood glucose level 72 of 20 μJ is 57 mg / dl,
The error from the estimated blood glucose level 72 of 40 μJ is 42 mg / dl,
The error from the estimated blood glucose level 72 of 60 μJ is 90 mg / dl,
The error from the estimated blood glucose level 72 of 80 μJ is 0 mg / dl,
The error from the estimated blood glucose level 72 of 100 μJ is 0 mg / dl.

  Next, the light quantity selection unit 271 calculates an average of errors in each light quantity, and outputs the smallest light quantity as the light quantity instruction signal 71 with the calculated average error being equal to or less than the preset estimation error register A272.

The average error in each light quantity is
31 mg / dl when the light intensity is 20 μJ,
26 mg / dl when the light intensity is 40 μJ,
12 mg / dl when the light intensity is 60 μJ,
2.4 mg / dl when the light intensity is 80 μJ,
When the amount of light is 100 μJ, it is 1.5 mg / dl.

  The light quantity selecting means 271 outputs the average error calculated below the average error threshold value (10 mg / dl) preset in the estimation error register A 272 and the smallest light quantity of 80 μJ as the light quantity instruction signal 71, and the estimated blood glucose level. The value 72 is output to the outside.

  When the light intensity instruction signal 71 output from the blood sugar level estimation means 207 is input to the control means 208, the light intensity change means 281 changes the light intensity 81 used in the normal measurement period to 80 μJ according to the light intensity instruction signal 71. .

  When the light quantity periodic confirmation means 285 detects the light quantity instruction signal 71, it starts measuring the elapsed time.

  Here, the estimated blood glucose level 72 from time 0 minutes to time 60 minutes is calculated using the calculated calibration data, and the error between the blood glucose level of the invasive blood glucose measurement device and the estimated blood glucose level 72 at each measurement time is calculated. Although it has been described that the light quantity 81 used in the normal measurement period is determined by obtaining the average, the light quantity 81 used in the normal measurement period is determined by obtaining an error at the timing when the calibration data is calculated, or the result during the calibration period. Other methods for determining the amount of light 81 to be used in the normal measurement period using may be used.

  When the calibration period ends, the normal measurement period starts, and measurement is performed with the noninvasive blood sugar level measuring apparatus every 6 minutes after time 66 minutes.

  When the time is 66 minutes, the elapsed time is 6 minutes.

  Since the elapsed time does not exceed 30 minutes preset in the confirmation cycle register A286, the control unit 208 controls the 80 μJ light amount 81 and the lighting timing 82 determined in the calibration period to turn on the light source 201, and the light 103 Is used to calculate the feature quantity 61 of the biological information from the photoacoustic wave signal 105 generated from the substance that can estimate the blood glucose level in the blood vessel 104, and from the feature quantity 61 calculated by the blood glucose level estimation means 207, the estimated blood glucose level is calculated based on the calibration data. A series of processing for obtaining the value 72 and outputting it to the outside is the same as the calibration period.

  The measurement with the noninvasive blood glucose measurement device is performed every 6 minutes after the time 72 minutes until the elapsed time exceeds 30 minutes, as in the case of the elapsed time 66 minutes.

  When the time is 96 minutes, the elapsed time is 36 minutes.

  Since the elapsed time exceeds 30 minutes preset in the confirmation cycle register A286, the control unit 208 calculates the estimated blood glucose level 72 with the light amount 81 of 80 μJ determined in the calibration period, and then the light amount periodic confirmation unit 285 The estimated blood glucose level 72 is measured with a light amount 81 of 100 μJ set in the confirmation light amount register 287 in advance.

  First, the control means 208 controls the light amount 81 of 80 μJ and the lighting timing 82 to turn on the light source 201, and the characteristics of the biological information from the photoacoustic wave signal 105 generated from the substance that can estimate the blood glucose level in the blood vessel 104 by the light 103. An amount 61 is calculated, and an estimated blood glucose level 72 is obtained from the feature amount 61 calculated by the blood glucose level estimation means 207 based on the calibration data. Assume that the estimated blood glucose level 72 of 80 μJ is 162 mg / dl.

  Next, the light quantity periodic confirmation means 285 turns on the light source 201 with a light quantity 81 of 100 μJ preset in the confirmation light quantity register 287, resets the elapsed time that has been counted so far, and starts measuring the elapsed time anew. To do. A feature quantity 61 of biological information is calculated from a photoacoustic wave signal 105 generated from a substance capable of estimating a blood glucose level in the blood vessel 104 by the light 103 from the light source 201, and calibration is performed from the feature quantity 61 calculated by the blood glucose level estimation means 207. An estimated blood glucose level 72 is obtained based on 100 μJ calibration data calculated during the period. Assume that the estimated blood glucose level 72 of 100 μJ is 163 mg / dl.

  The light amount appropriateness checking unit 273 provided in the blood glucose level estimation unit 207 compares the estimated blood glucose level (162 mg / dl) with the light amount of 80 μJ and the estimated blood glucose level (163 mg / dl) with the light amount of 100 μJ to calculate the error (1 mg / dl). Then, it is determined whether this error is 3 mg / dl or less preset in the appropriate error register A274. Since the error is equal to or less than the preset appropriate error register A 274, the light amount restoration signal 73 is output to the control unit 208 so as to return the light amount to 80 μJ set before the light amount regular confirmation unit 285 changes. As a result of the determination by the light quantity appropriateness confirmation unit 273, if the error is larger than the preset appropriate error register A274, the light quantity restoration signal 73 is not output.

  When the control means 208 detects the light quantity restoration signal 73 output from the blood sugar level estimation means 207, the light quantity changing means 281 returns the light quantity 81 to 80 μJ according to the light quantity restoration signal 73. If the light amount restoration signal 73 cannot be detected, the subsequent measurement is performed with the light amount 81 changed by the light amount periodic confirmation means 285 (100 μJ preset in the confirmation light amount register 287).

  The estimated blood glucose level 72 is measured at a light intensity of 80 μJ every 6 minutes after the time 102 minutes until the elapsed time exceeds 30 minutes set in advance in the confirmation cycle register A286 as in the case of time 66 minutes.

  As described above, according to the noninvasive living body information measurement device according to Embodiment 1 of the present invention, the noninvasive blood glucose measurement device 101 performs measurement with a plurality of light amounts during the calibration period, and calculates a plurality of light amounts calculated with the respective light amounts. Calculate multiple estimated blood glucose levels from feature values and blood glucose levels measured with an invasive blood glucose measurement device, and compare and calculate blood glucose levels measured with the invasive blood glucose measurement device and multiple estimated blood glucose levels at the end of the calibration period The average error is less than the preset threshold value and the normal measurement period is measured with the smallest amount of light, so it is lower than when measuring with a high amount of light regardless of the user's biological condition. Power consumption can be realized, and the continuous measurement time when realized with a portable device can be greatly extended.

  In the first embodiment of the present invention, the average error calculated by comparing the blood glucose level measured by the invasive blood glucose measurement device calculated at the end of the calibration period with a plurality of estimated blood glucose levels is equal to or less than a preset threshold value. In addition, although it has been described that the measurement is performed in the normal measurement period with the smallest light quantity, an approximate curve with an error average for each light quantity is obtained, and the light quantity that falls below the threshold is newly calculated to calculate the light quantity used in the normal measurement period The same effect as described above may be obtained.

In the first embodiment of the present invention, the non-invasive blood glucose measurement device 101 has been described as assuming a device using photoacoustics. However, the non-invasive blood glucose measurement device 101 may be another device that non-invasively determines a blood glucose level, The same effect as above can be obtained.
(Embodiment 2)
In Embodiment 2 of the present invention, it is assumed that the noninvasive living body information measurement device is a noninvasive blood glucose measurement device 101.

  FIG. 5 is a diagram showing a system configuration diagram according to Embodiment 2 of the present invention. In FIG. 5, 101 is a noninvasive blood glucose measuring device, 102 is the surface of a living body, 103 is light, 104 is a blood vessel, and 105 is a photoacoustic wave signal. (A) is an activation signal 83, (b) is a lighting timing 82, (c) is a photoacoustic wave signal 105, (d) is an end signal 84, and (e) is an estimated blood sugar level calculation timing. A series of operations is performed every measurement period, with repeated measurement, with the interval for estimating the blood glucose level as the measurement basic cycle.

  The noninvasive blood glucose measuring device 101 is mounted so as to be in contact with the surface 102 of the living body, and the light 103 irradiated by the noninvasive blood glucose measuring device 101 is incident on the living body. The light 103 propagates in the living body and is absorbed by a substance that can estimate the blood glucose level in the blood vessel 104, and a photoacoustic wave signal 105 is generated.

  The noninvasive blood glucose measuring device 101 detects a photoacoustic wave signal 105 generated by a substance that can estimate the blood glucose level in the blood vessel 104, and estimates a blood glucose level that is a characteristic amount of biological information.

  FIG. 6 is a diagram showing a block configuration of the noninvasive blood glucose measurement device 101 according to the second embodiment of the present invention. In FIG. 6, 101 is a non-invasive blood glucose measurement device, 201 is a light source, 202 is a biological information sensor, 203 is an amplification means, 204 is an A / D conversion means, 205 is a storage means, 206 is a feature amount detection means, 601 A blood glucose level estimation unit 701 is a control unit.

  The light source 201 includes at least one light source, and emits light 103 having a wavelength that is absorbed by a substance capable of estimating a blood glucose level in the blood vessel 104. The control unit 208 includes a repetition number changing unit 711 and a repetition number periodic confirmation unit 715. The control unit 208 changes the lighting timing 82 of the light source 201 according to the repetition number instruction signal 615, controls the light amount 81 of the light source 201, and An activation signal 83 is output to the amplification means 203 and the A / D conversion means 204, and an end signal 84 is output to the amplification means 203, the A / D conversion means 204, the feature amount detection means 206, and the blood sugar level estimation means 207.

  The repeat count changing unit 711 outputs the lighting timing 82 to the light source 201 in accordance with the repeat count instruction signal 615 output from the blood sugar level estimating unit 207.

  The repeat count periodic confirmation means 715 changes the lighting timing 82 to the repeat count of the value preset in the check repeat count register 717 at the cycle preset in the check cycle register A286 for the light source 201 in the normal measurement period. And output.

  The biological information sensor 202 converts the photoacoustic wave signal 105 into the voltage signal 21. The amplifying unit 203 detects the voltage signal 21 based on the activation signal 83 from the control unit 208 and generates an amplified signal 31.

  The A / D conversion unit 204 converts the amplified signal 31 into sampling data 41 based on the activation signal 83 from the control unit 208.

  The storage unit 205 is an area for storing the sampling data 41, written by the A / D conversion unit 204, and read by the feature amount detection unit 206.

  A series of operations until the light source 201 is turned on and the sampling data 41 is stored is repeated a predetermined number of times.

  The feature amount detection means 206 averages the stored data 51 for a predetermined number of times, analyzes the averaged data, and calculates the feature amount 61 of the biological information.

  The blood sugar level estimation means 207 is composed of a repetition number selection means 611 and a repetition number appropriateness confirmation means 613, and the amount of change in blood sugar level measured by an invasive blood sugar measurement device (not shown) is stored in the calibration blood sugar threshold register 275 in advance. Calibration data is calculated when the threshold value is equal to or greater than the set threshold value, and based on the calculated calibration data, the estimated blood glucose level 72 is calculated from the feature amount 61 calculated by the feature amount detecting means 206 and the blood glucose level measured by the invasive blood glucose measuring device. Is output to the outside.

  The repetition frequency selection means 611 compares the blood glucose level measured by the invasive blood glucose measurement device with a plurality of estimated blood glucose levels, calculates the average error, and the average error is less than or equal to a threshold value set in advance in the estimation error register B612. In addition, the smallest number of repetitions is detected, and the repetition number instruction signal 615 is output.

  The repeat count appropriateness checking means 613 is an estimated blood glucose level measured at the repeat count changed by the repeat count periodic check means 715 and an estimate measured at the repeat count set before being changed by the repeat count periodic check means 715. The blood glucose level is compared to calculate an error, and it is determined whether the error is less than or equal to a threshold value set in advance in the appropriate error register B 614. If the error is less than or equal to the threshold value, the control means 208 is periodically checked repeatedly. The repetition number restoration signal 616 is output so as to return to the number of repetitions set before being changed by the means 715.

  FIG. 7 is a diagram in which the estimated blood glucose level 72 of the non-invasive blood glucose measurement device 101 according to the second embodiment of the present invention is plotted on the time axis. 7, (a) is an estimated blood glucose level 72, (b) is an enlarged view of the estimated blood glucose level 72 (time 10 minutes to time 20 minutes and time 90 minutes to time 100 minutes), and (c) is the number of repetitions. .

  Hereinafter, the operation when the noninvasive blood glucose measuring device 101 performs continuous blood glucose measurement will be described with reference to FIGS. 5, 6, and 7.

  In the second embodiment of the present invention, the measurement with the invasive blood glucose measurement device is performed at 10-minute intervals, and the measurement with the non-invasive blood glucose measurement device 101 is performed by the control means 208 using the amplification means 203 and the A / D conversion means 204. The interval from when the first activation signal 83 is output until the blood glucose level estimation means 207 calculates the estimated blood glucose level 72 and outputs it to the outside is defined as a measurement basic cycle and is repeated at intervals of 6 minutes.

Here, as an initial value of a register writable from the outside,
100 times as the minimum repetition number value (minimum repetition number register 712) of the repetition number changing means 711,
As the amount of increase of the number of repetitions of the repetition number changing means 711 (incremental repetition number register 713),
300 times as the maximum repetition number value (maximum repetition number register 714) of the repetition number changing means 711,
10 mg / dl as an average threshold value (estimation error register B 612) of an error between the blood glucose level measured by the invasive blood glucose measurement device of the repetition number selection means 611 and the estimated blood glucose level 72
30 minutes as a period (confirmation period register B 716) for changing the number of repetitions of the repetition number periodic confirmation means 715,
300 times as the repeat count (confirmation repeat count register 717) of the repeat count periodic confirmation means 715,
Estimated blood sugar level measured by the repetition number changed by the repetition number periodic confirmation unit 715 of the repetition number appropriate confirmation unit 613 and the estimated blood sugar level measured by the repetition number set before being changed by the repetition number periodic confirmation unit 715 3 mg / dl as a value error (appropriate error register B614),
70 mg / dl is set as the blood glucose level change amount (calibration blood glucose threshold register 275) of the invasive blood glucose measuring device necessary for calculating the calibration data.

  First, at time 0 minutes, when a blood collection switch (not shown) provided in the invasive blood glucose measurement device is pressed by the user, measurement of a blood glucose level accompanying blood collection is started. Blood is collected from the living body by a blood collecting means such as a puncture needle, and the blood glucose level is measured.

  The blood glucose level at this time is 70 mg / dl.

  The user transmits blood glucose measurement information 91 (time 0 minutes: 70 mg / dl) such as a blood glucose level measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101. Blood glucose measurement information 91 is input by an information input means (not shown).

  The input blood glucose measurement information 91 is stored in the storage unit 205.

  Here, the blood glucose measurement information 91 measured by the invasive blood glucose measurement device is input to the non-invasive blood glucose measurement device 101 by the user, but the invasive blood glucose measurement device automatically transfers to the non-invasive blood glucose measurement device 101. May be transferred.

  As shown in FIG. 5, the noninvasive blood glucose measuring device 101 is attached to the surface 102 of a living body such as an arm, and then the blood glucose level measurement start switch (not shown) provided on the noninvasive blood glucose measuring device 101 by the user. Is activated, the control unit 208 outputs an activation signal 83 to the amplification unit 203 and the A / D conversion unit 204, and the light amount 81 of the light source 201 is turned on at the timing when the amplification unit 203 and the A / D conversion unit 204 enter a stable operation. The timing 82 is controlled and the light source 201 is turned on.

  At this time, 100 is set in the minimum repetition number register 712 included in the repetition number changing unit 711, and the control unit 701 counts the number of lightings until the light source 201 is turned on 100 times.

  Here, the invasive blood glucose measurement device and the noninvasive blood glucose measurement device 101 have been described as being started by the user simultaneously pressing the blood collection switch and the measurement start switch, but the measurement is performed at the same time. The non-invasive blood glucose measurement device 101 may be activated from the invasive blood glucose measurement device and measurement may be started. Alternatively, the invasive blood glucose measurement device may be activated from the non-invasive blood glucose measurement device 101 to start measurement. May be.

  The light 103 from the light source 201 propagates in the living body and is absorbed by a substance capable of estimating the blood glucose level in the blood vessel 104 to generate a photoacoustic wave signal 105.

  The biological information sensor 202 converts the pressure of the photoacoustic wave signal 105 into the voltage signal 21.

  The amplification means 203 receives the activation signal 83 from the control means 208, amplifies the voltage signal 21 converted by the biological information sensor 202 with a preset gain, and outputs the amplified signal 31 to the A / D conversion means 204. To do.

  Here, the start signal 83 and the end signal 84 are input to the amplifying means 203 because the operation of an element such as an operational amplifier, which is a component of the amplifying means 203, is performed only at the timing when the photoacoustic wave signal 105 is generated. This is for the purpose of reducing the power consumption of the amplifying means 203 for enabling. Accordingly, even if these signals are not input, it is possible to perform the same operation.

  The A / D conversion unit 204 receives the activation signal 83 from the control unit 208, performs analog-digital conversion on the amplified signal 31 output from the amplification unit 203 at a specific interval, and writes the sampling data 41 in the storage unit 205.

  Here, the reason why the start signal 83 and the end signal 84 are input to the A / D conversion means 204 is AD that is a component of the A / D conversion means 204 only at the timing when the photoacoustic wave signal 105 is generated. This is for enabling the operation of an element such as a converter, and for the purpose of reducing the power consumption of the A / D conversion means 204. Accordingly, even if these signals are not input, it is possible to perform the same operation.

  A series of operations until the light source 201 is turned on and the sampling data 41 is stored is repeated 100 times. When the feature amount detection unit 206 receives the end signal 84 from the control unit 701, 100 is stored in the storage unit 205. The stored data 51 is read and averaged, the averaged data is analyzed, and the feature quantity 61 of the biological information when the number of repetitions is 100 is calculated and stored.

  When the number of times of lighting reaches 100 times, the repetition number changing means 711 compares whether the number of times of lighting is equal to or greater than the number of repetitions (300 times) set in the maximum repetition number register 714.

  Since the number of lighting times is smaller than the maximum repetition number register 714, the repetition number changing means 711 continues to control the lighting timing 82 by the amount of increase of the repetition number set in the increase repetition number register 713 (100 times). The light source 201 is turned on until the sampling time is reached, and a series of operations until the sampling data 41 is stored is repeated.

  When the feature amount detection unit 206 receives the end signal 84 from the control unit 701, the stored data 51 for 200 times stored in the storage unit 205 is read out and averaged, and the averaged data is analyzed and the number of repetitions is 200. The feature amount 61 of the biological information at the time of the calculation is calculated and stored.

  When the lighting number reaches 200, the repetition number changing means 711 compares the lighting number with the repetition number (300 times) or more set in the maximum repetition number register 714.

  Since the lighting number is smaller than the maximum repetition number register 714, the repetition number changing means 711 continues to control the lighting timing 82 by the increment of the repetition number set in the increase repetition number register 713 (100 times), and the lighting number is 300 times. The light source 201 is turned on until the sampling data 41 is stored until the light source 201 is turned on.

  When the feature amount detection unit 206 receives the end signal 84 from the control unit 701, the stored data 51 stored in the storage unit 205 is read out and averaged, the averaged data is analyzed, and the number of repetitions is 300. The feature amount 61 of the biological information at the time of the calculation is calculated and stored.

  When the number of times of lighting reaches 300 times, the repetition number changing means 711 compares whether the number of lighting times is equal to or greater than the number of repetitions (300 times) set in the maximum repetition number register 714.

  Since the number of lightings is greater than or equal to the maximum number of repetitions register 714, the number of repetitions change unit 711 returns the number of repetitions to the minimum number of repetitions (100 times) set in the minimum number of repetitions register 712, and the next noninvasive blood glucose measuring device 101 Wait until the measurement timing (6 minutes).

  Here, lighting is performed from the minimum number of repetitions (100 times) to the maximum number of repetitions (300 times) according to the register group (minimum repetition number register 712, incremental repetition number register 713, maximum repetition number register 714) provided in the light amount changing means 281. Although the timing 82 is changed, a method of changing the number of repetitions by providing a register group for setting a plurality of repetitions may be used.

  When the time is 6 minutes, the measurement with the non-invasive blood glucose measurement device 101 is performed at intervals of 6 minutes, so that the light source 201 is turned on at intervals of 100 times from 100 times to 300 times, similarly to the time of 0 minutes. A series of operations for saving the feature quantity 61 is performed.

  When the measurement with 300 repetitions is completed, the repetition number changing means 711 returns the repetition number to the minimum repetition number (100 times) set in the minimum repetition number register 712, and the next noninvasive blood glucose measurement device 101 Wait until the measurement timing (12 minutes).

  When the time is 10 minutes, as in the case of time 0 minutes, when the user presses a blood collection switch included in the invasive blood glucose measurement device, the measurement is started, and measurement is performed with the invasive blood glucose measurement device. The measurement method is the same as that at time 0 minutes.

  The blood glucose level at this time is 82 mg / dl.

  The user inputs blood glucose measurement information 91 (time 10 minutes: 82 mg / dl) measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101.

  The input blood glucose measurement information 91 is stored in the storage unit 205 and also input to the blood glucose level estimation unit 207, and is compared with the blood glucose level (70 mg / dl) at time 0 to calculate a change amount of 12 mg / dl. Since the calculated change amount is smaller than the threshold value 70 mg / dl set in the calibration blood glucose threshold register 275, the measurement with the invasive blood glucose measurement device is continued.

  At time 12 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 100 times from 100 to 300 times and storing the feature value 61, as in the case of time 6 minutes. Do.

  When the measurement with 300 repetitions is completed, the repetition number changing means 711 returns the repetition number to the minimum repetition number (100 times) set in the minimum repetition number register 712, and the next noninvasive blood glucose measurement device 101 Wait until the measurement timing (18 minutes).

  At time 18 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 100 times from 100 to 300 times and storing the feature value 61, as in the case of time 6 minutes. Do.

  When the measurement with 300 repetitions is completed, the repetition number changing means 711 returns the repetition number to the minimum repetition number (100 times) set in the minimum repetition number register 712, and the next noninvasive blood glucose measurement device 101 Wait until the measurement timing (24 minutes).

  When the time is 20 minutes, as in the case of time 0 minutes, when the user presses a blood collection switch provided in the invasive blood glucose measurement device, the measurement is started, and measurement is performed with the invasive blood glucose measurement device. The measurement method is the same as that at time 0 minutes.

  The blood glucose level at this time is 100 mg / dl.

  The user inputs blood glucose measurement information 91 (time 20 minutes: 100 mg / dl) measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101.

  The input blood glucose measurement information 91 is stored in the storage unit 205 and is also input to the blood glucose level estimation unit 207 and is compared with the blood glucose level (70 mg / dl) at time 0 to calculate a change amount of 30 mg / dl. Since the calculated change amount is smaller than the threshold value 70 mg / dl set in the calibration blood glucose threshold register 275, the measurement with the invasive blood glucose measurement device is continued.

  When the time is 24 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 100 times from 100 to 300 times and storing the feature quantity 61 as in the case of time 6 minutes. Do.

  When the measurement with 300 repetitions is completed, the repetition number changing means 711 returns the repetition number to the minimum repetition number (100 times) set in the minimum repetition number register 712, and the next noninvasive blood glucose measurement device 101 Wait until the measurement timing (30 minutes).

  When the time is 30 minutes, as in the case of time 0 minutes, when the user presses a blood collection switch provided in the invasive blood glucose measurement device, the measurement is started, and measurement is performed with the invasive blood glucose measurement device. The measurement method is the same as that at time 0 minutes.

  The blood glucose level at this time is 118 mg / dl.

  The user inputs blood glucose measurement information 91 (time 30 minutes: 118 mg / dl) measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101.

  The input blood glucose measurement information 91 is stored in the storage unit 205 and also input to the blood glucose level estimation unit 207, and is compared with the blood glucose level (70 mg / dl) at time 0 to calculate a change amount of 48 mg / dl. Since the calculated change amount is smaller than the threshold value 70 mg / dl set in the calibration blood glucose threshold register 275, the measurement with the invasive blood glucose measurement device is continued.

  The non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 100 times from 100 to 300 times and storing the feature value 61, as in the case of 6 minutes.

  When the measurement with 300 repetitions is completed, the repetition number changing means 711 returns the repetition number to the minimum repetition number (100 times) set in the minimum repetition number register 712, and the next noninvasive blood glucose measurement device 101 Wait until the measurement timing (36 minutes).

  When the time is 36 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations to turn on the light source 201 at intervals of 100 times from 100 times to 300 times and to store the feature value 61 as in the case of time 6 minutes. Do.

  When the measurement with 300 repetitions is completed, the repetition number changing means 711 returns the repetition number to the minimum repetition number (100 times) set in the minimum repetition number register 712, and the next noninvasive blood glucose measurement device 101 Wait until the measurement timing (42 minutes).

  When the time is 40 minutes, as in the case of time 0 minutes, when the user presses a blood collection switch provided in the invasive blood glucose measurement device, the measurement is started, and measurement is performed with the invasive blood glucose measurement device. The measurement method is the same as that at time 0 minutes.

  The blood glucose level at this time is 125 mg / dl.

  The user inputs blood glucose measurement information 91 (time 40 minutes: 125 mg / dl) measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101.

  The input blood glucose measurement information 91 is stored in the storage unit 205 and also input to the blood glucose level estimation unit 207, and is compared with the blood glucose level (70 mg / dl) at time 0 to calculate a change amount of 60 mg / dl. Since the calculated change amount is smaller than the threshold value 70 mg / dl set in the calibration blood glucose threshold register 275, the measurement with the invasive blood glucose measurement device is continued.

  When the time is 42 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 100 times from 100 to 300 times and storing the feature value 61 as in the case of time 6 minutes. Do.

  When the measurement with the 300 repetitions is completed, the repetition number changing unit 711 returns the repetition number to the minimum repetition number (100 times) set in the minimum repetition number register 712, and the next noninvasive blood glucose measurement device 101 performs the measurement. Wait until the measurement timing (48 minutes).

  When the time is 48 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 100 times from 100 to 300 times and storing the feature value 61 as in the case of time 6 minutes. Do.

  When the measurement with 300 repetitions is completed, the repetition number changing means 711 returns the repetition number to the minimum repetition number (100 times) set in the minimum repetition number register 712, and the next noninvasive blood glucose measurement device 101 Wait until the measurement timing (54 minutes).

  When the time is 50 minutes, as in the case of time 0 minutes, when the user presses a blood collection switch provided in the invasive blood glucose measurement device, the measurement is started, and measurement is performed with the invasive blood glucose measurement device. The measurement method is the same as that at time 0 minutes.

  The blood glucose level at this time is 138 mg / dl.

  The user inputs blood glucose measurement information 91 (time 50 minutes: 138 mg / dl) measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101.

  The input blood glucose measurement information 91 is stored in the storage unit 205 and also input to the blood glucose level estimation unit 207, and is compared with the blood glucose level (70 mg / dl) at time 0 to calculate a change amount of 68 mg / dl. Since the calculated change amount is smaller than the threshold value 70 mg / dl set in the calibration blood glucose threshold register 275, the measurement with the invasive blood glucose measurement device is continued.

  When the time is 54 minutes, the non-invasive blood glucose measurement device 101 performs a series of operations for turning on the light source 201 at intervals of 100 times from 100 to 300 times and storing the feature value 61 as in the case of time 6 minutes. Do.

  When the measurement with 300 repetitions is completed, the repetition number changing means 711 returns the repetition number to the minimum repetition number (100 times) set in the minimum repetition number register 712, and the next noninvasive blood glucose measurement device 101 Wait until the measurement timing (60 minutes).

  When the time is 60 minutes, as in the case of time 0 minutes, when the user presses the blood collection switch included in the invasive blood glucose measurement device, the measurement is started, and measurement is performed with the invasive blood glucose measurement device. The measurement method is the same as that at time 0 minutes.

  The blood glucose level at this time is 142 mg / dl.

  The user inputs blood glucose measurement information 91 (time 60 minutes: 142 mg / dl) measured by the invasive blood glucose measurement device to the non-invasive blood glucose measurement device 101.

  The input blood glucose measurement information 91 is stored in the storage unit 205 and also input to the blood glucose level estimation unit 207, and is compared with the blood glucose level (70 mg / dl) at time 0 to calculate a change amount of 72 mg / dl. Since the calculated change amount is not less than the threshold value 70 mg / dl set in the calibration blood glucose threshold value register 275, seven data of the invasive blood glucose measurement device measured so far (time 0 minutes: 70 mg / dl, time 10 minutes: 82 mg / dl, time 20 minutes: 100 mg / dl, time 30 minutes: 118 mg / dl, time 40 minutes: 125 mg / dl, time 50 minutes: 138 mg / dl, time 60 minutes: 142 mg / dl) The calculated approximate curve 402 is obtained. Further, the approximate blood glucose level measured by the noninvasive blood glucose measurement device 101 is calculated from the approximate curve 402, and the number of repetitions is based on the approximate blood glucose level and the feature value 61 of the noninvasive blood glucose measurement device 101 for each repetition frequency. Calculate calibration data.

  Based on the calculated calibration data, an estimated blood glucose level 72 for each number of repetitions from time 0 minutes to time 60 minutes is obtained.

When the estimated blood glucose level 72 at each measurement time is calculated based on the calibration data,
When time is 0 minutes
The estimated blood glucose level 72 with 100 repetitions is 68 mg / dl,
The estimated blood glucose level 72 for 200 repetitions is 70 mg / dl,
The estimated blood glucose level 72 with 300 repetitions is 70 mg / dl.

At 6 minutes
The estimated blood glucose level 72 with 100 repetitions is 75 mg / dl,
The estimated blood glucose level 72 with 200 repetitions is 78 mg / dl,
The estimated blood glucose level 72 of 300 repetitions is 78 mg / dl.

At 12 minutes
The estimated blood glucose level 72 with 100 repetitions is 82 mg / dl,
The estimated blood glucose level 72 with 200 repetitions is 84 mg / dl,
The estimated blood glucose level 72 with 300 repetitions is 87 mg / dl.

At 18 minutes
The estimated blood glucose level 72 with 100 repetitions is 84 mg / dl,
The estimated blood glucose level 72 with 200 repetitions is 90 mg / dl,
The estimated blood glucose level 72 after 300 repetitions is 94 mg / dl.

At 24 hours
The estimated blood glucose level 72 with 100 repetitions is 87 mg / dl,
The estimated blood glucose level 72 with 200 repetitions is 98 mg / dl,
The estimated blood glucose level 72 with 300 repetitions is 108 mg / dl,
At 30 minutes
The estimated blood glucose level 72 with 100 repetitions is 95 mg / dl,
The estimated blood glucose level 72 with 200 repetitions is 110 mg / dl,
The estimated blood glucose level 72 with 300 repetitions is 115 mg / dl.

At 36 minutes
The estimated blood glucose level 72 with 100 repetitions is 100 mg / dl,
Estimated blood glucose level 72 with 200 repetitions is 112 mg / dl,
The estimated blood glucose level 72 after 300 repetitions is 119 mg / dl.

At 42 minutes
The estimated blood glucose level 72 with 100 repetitions is 101 mg / dl,
The estimated blood glucose level 72 with 200 repetitions is 120 mg / dl,
The estimated blood glucose level 72 with 300 repetitions is 129 mg / dl.

At 48 minutes
The estimated blood glucose level 72 with 100 repetitions is 102 mg / dl,
The estimated blood glucose level 72 with 200 repetitions is 125 mg / dl,
The estimated blood glucose level 72 with 300 repetitions is 134 mg / dl.

At 54 minutes
The estimated blood glucose level 72 with 100 repetitions is 102 mg / dl,
The estimated blood glucose level 72 with 200 repetitions is 134 mg / dl,
The estimated blood glucose level 72 with 300 repetitions is 138 mg / dl.

At 60 minutes
The estimated blood glucose level 72 with 100 repetitions is 103 mg / dl,
The estimated blood glucose level 72 for 200 repetitions is 138 mg / dl,
The estimated blood glucose level 72 with 300 repetitions is 142 mg / dl.

  Next, the repetition number selection means 611 measures the estimated blood glucose level 72 of the non-invasive blood glucose measurement device and the blood glucose level of the invasive blood glucose measurement device or the blood glucose level for each number of repetitions from time 0 to time 60 minutes. If not, an error is calculated by comparing with the approximate blood glucose level.

When calculating the error at each measurement time,
At time 0 minutes, the blood glucose level of the invasive blood glucose measuring device is 70 mg / dl,
The error from the estimated blood glucose level 72 of 100 repetitions is 2 mg / dl,
The error from the estimated blood glucose level 72 of 200 repetitions is 0 mg / dl,
The error from the estimated blood glucose level 72 of 300 repetitions is 0 mg / dl.

At time 6 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 78 mg / dl.
The error from the estimated blood glucose level 72 of 100 repetitions is 3 mg / dl,
The error from the estimated blood glucose level 72 of 200 repetitions is 0 mg / dl,
The error from the estimated blood glucose level 72 of 300 repetitions is 0 mg / dl.

When the time is 12 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 89 mg / dl.
The error from the estimated blood glucose level 72 of 100 repetitions is 7 mg / dl,
The error from the estimated blood glucose level 72 of 200 repetitions is 5 mg / dl,
The error from the estimated blood glucose level 72 of 300 repetitions is 2 mg / dl.

At time 18 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 98 mg / dl.
The error from the estimated blood glucose level 72 of 100 repetitions is 14 mg / dl,
The error from the estimated blood glucose level 72 of 200 repetitions is 8 mg / dl,
The error from the estimated blood glucose level 72 of 300 repetitions is 4 mg / dl.

When the time is 24 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 107 mg / dl.
The error from the estimated blood glucose level 72 of 100 repetitions is 20 mg / dl,
The error from the estimated blood glucose level 72 of 200 repetitions is 9 mg / dl,
The error from the estimated blood glucose level 72 of 300 repetitions is 1 mg / dl.

At time 30 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 118 mg / dl.
The error from the estimated blood glucose level 72 of 100 repetitions is 23 mg / dl,
The error from the estimated blood glucose level 72 of 200 repetitions is 8 mg / dl,
The error from the estimated blood glucose level 72 of 300 repetitions is 3 mg / dl.

When the time is 36 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 122 mg / dl.
The error from the estimated blood glucose level 72 of 100 repetitions is 22 mg / dl,
The error from the estimated blood glucose level 72 of 200 repetitions is 10 mg / dl,
The error from the estimated blood glucose level 72 of 300 repetitions is 3 mg / dl.

At time 42 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 128 mg / dl,
The error from the estimated blood glucose level 72 of 100 repetitions is 27 mg / dl,
The error from the estimated blood glucose level 72 of 200 repetitions is 8 mg / dl,
The error from the estimated blood glucose level 72 of 300 repetitions is 1 mg / dl.

At time 48 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 133 mg / dl.
The error from the estimated blood glucose level 72 of 100 repetitions is 31 mg / dl,
The error from the estimated blood glucose level 72 of 200 repetitions is 8 mg / dl,
The error from the estimated blood glucose level 72 of 300 repetitions is 1 mg / dl.

At time 54 minutes, the approximate blood glucose level of the invasive blood glucose measurement device is 138 mg / dl,
The error from the estimated blood glucose level 72 of 100 repetitions is 36 mg / dl,
The error from the estimated blood glucose level 72 of 200 repetitions is 4 mg / dl,
The error from the estimated blood glucose level 72 of 300 repetitions is 0 mg / dl.

When the time is 60 minutes, the approximate blood glucose level of the invasive blood glucose measuring device is 142 mg / dl.
The error from the estimated blood glucose level 72 of 100 repetitions is 39 mg / dl,
The error from the estimated blood glucose level 72 of 200 repetitions is 4 mg / dl,
The error from the estimated blood glucose level 72 of 300 repetitions is 0 mg / dl.

  Next, the repetition number selection means 611 calculates the average of the errors in each repetition number, and the average of the calculated errors is equal to or less than the preset estimation error register B 612, and the smallest repetition number is set as the repetition number indication signal 615. Output as.

The average error at each iteration is
20 mg / dl at 100 repetitions,
5.8 mg / dl at 200 repetitions,
When the number of repetitions is 300, it becomes 1.4 mg / dl.

  The repetition number selection means 611 outputs the average of the calculated errors below the average error threshold (10 mg / dl) preset in the estimation error register B 612 and outputs the smallest number of repetitions 200 as the repetition number instruction signal 615. At the same time, the estimated blood glucose level 72 is output to the outside.

  When the repeat count instruction signal 615 output from the blood sugar level estimating means 207 is input to the control means 208, the repeat count changing means 711 sets the repeat count used in the normal measurement period to 200 according to the repeat count instruction signal 615. Change to times.

  When the repeat count periodic confirmation means 715 detects the repeat count instruction signal 615, the repeat count regular check means 715 starts measuring the elapsed time.

  Here, the estimated blood glucose level 72 from time 0 minutes to time 60 minutes is calculated using the calculated calibration data, and the error between the blood glucose level of the invasive blood glucose measurement device and the estimated blood glucose level 72 at each measurement time is calculated. Although it has been explained that the average is calculated and the number of repetitions used in the normal measurement period is determined, the error is calculated at the timing when the calibration data is calculated to determine the number of repetitions used in the normal measurement period, and the result during the calibration period Other methods may be used in which the number of repetitions used in the normal measurement period is determined using.

  When the calibration period ends, the normal measurement period starts, and measurement is performed with the noninvasive blood sugar level measuring apparatus every 6 minutes after time 66 minutes.

  When the time is 66 minutes, the elapsed time is 6 minutes.

  Since the elapsed time does not exceed 30 minutes preset in the confirmation cycle register B 716, the control unit 208 controls the lighting timing 82 for the number of repetitions (200 times) determined in the calibration period to turn on the light source 201. Based on the calibration data, the feature quantity 61 of the biological information is calculated from the photoacoustic wave signal 105 generated from the substance capable of estimating the blood sugar level in the blood vessel 104 by the light 103, and the blood sugar level estimation means 207 calculates the feature quantity 61. A series of processes for obtaining the estimated blood glucose level 72 and outputting it to the outside is the same as the calibration period.

  The measurement with the noninvasive blood glucose measurement device is performed every 6 minutes after the time 72 minutes until the elapsed time exceeds 30 minutes, as in the case of the elapsed time 66 minutes.

  When the time is 96 minutes, the elapsed time is 36 minutes.

  Since the elapsed time exceeds 30 minutes preset in the confirmation cycle register A286, the control unit 208 calculates the estimated blood glucose level 72 at the lighting timing 82 of the number of repetitions (200 times) determined in the calibration period. The light source 201 is continuously turned on until the repetition number periodic confirmation means 715 reaches the number of repetitions of 300 preset in the confirmation light quantity register 287, and the estimated blood glucose level 72 is measured even at the number of repetitions of 300.

  First, the control means 208 controls the light amount 81 and the lighting timing 82 for the number of repetitions of 200 to turn on the light source 201, and from the photoacoustic wave signal 105 generated from the substance that can estimate the blood glucose level in the blood vessel 104 by the light 103. A feature amount 61 of the biological information is calculated, and an estimated blood glucose level 72 is obtained from the feature amount 61 calculated by the blood glucose level estimation means 207 based on the calibration data. It is assumed that the estimated blood glucose level 72 with 200 repetitions is 162 mg / dl.

  Next, the light source 201 is continuously turned on until the repetition number periodic confirmation means 715 reaches the number of repetitions of 300 preset in the confirmation repetition number register 717. The elapsed time that was being used is reset and measurement of the elapsed time is newly started. A feature quantity 61 of biological information is calculated from a photoacoustic wave signal 105 generated from a substance capable of estimating a blood glucose level in the blood vessel 104 by the light 103 from the light source 201, and calibration is performed from the feature quantity 61 calculated by the blood glucose level estimation means 207. Estimated blood glucose level 72 is obtained based on the calibration data calculated 300 times during the period. Assume that the estimated blood glucose level 72 of 300 repetitions is 163 mg / dl.

  The repetition frequency appropriateness checking means 613 provided in the blood glucose level estimation means 207 compares the estimated blood glucose level (162 mg / dl) with the repetition count of 200 times with the estimated blood glucose level (163 mg / dl) with the repetition count of 300 times to determine an error (1 mg / dl). dl) is calculated, and it is determined whether this error is 3 mg / dl or less preset in the appropriate error register B614. Since the error is equal to or smaller than the preset appropriate error register B 614, the repetition number restoration signal 616 is output to the control unit 208 so that the number of repetitions is set to 200 before being changed by the repetition number periodic confirmation unit 715. . As a result of the determination by the repetition number appropriateness checking means 613, if the error is larger than the preset appropriate error register B614, the repetition number restoration signal 616 is not output.

  When the control unit 208 detects the repetition number restoration signal 616 output from the blood sugar level estimation unit 207, the repetition number changing unit 711 returns the number of repetitions to 200 according to the repetition number restoration signal 616. When the repetition number restoration signal 616 cannot be detected, the subsequent measurement is performed with the number of repetitions changed by the repetition number periodic confirmation unit 715 (300 times set in advance in the confirmation repetition number register 717).

  The estimated blood sugar level 72 is measured every 200 minutes after the time 102 minutes until the elapsed time exceeds 30 minutes preset in the confirmation cycle register B 716 in the same manner as at time 66 minutes.

  As described above, according to the noninvasive living body information measurement device according to Embodiment 2 of the present invention, the measurement with the noninvasive blood glucose measurement device 101 is performed with a plurality of repetitions during the calibration period, and the calculation is performed with each repetition. Calculate multiple estimated blood glucose levels from multiple feature quantities and blood glucose levels measured with an invasive blood glucose measurement device, and compare the blood glucose levels measured with the invasive blood glucose measurement device with multiple estimated blood glucose levels at the end of the calibration period The average of the calculated error is less than a preset threshold and the normal measurement period is measured with the smallest number of repetitions, so low power consumption without reducing the accuracy of the noninvasive blood glucose measurement device And a reduction in measurement time can be realized, and the continuous measurement time when realized with a portable device can be greatly extended.

  In the second embodiment of the present invention, the average error calculated by comparing the blood glucose level measured by the invasive blood glucose measurement device calculated at the end of the calibration period with a plurality of estimated blood glucose levels is equal to or less than a preset threshold value. In addition, although it has been described that the measurement is performed in the normal measurement period with the smallest number of repetitions, an approximate curve of an error average for each number of repetitions is obtained, and the number of repetitions that falls below the threshold is newly calculated and used for the normal measurement period. The number of repetitions may be calculated, and the same effect as described above can be obtained.

  In the second embodiment of the present invention, the non-invasive blood glucose measurement device 101 has been described as assuming a device using photoacoustics, but may be another device that non-invasively determines a blood glucose level, The same effect as above can be obtained.

  As described above, the noninvasive biological information measuring device according to the present invention compares the estimated blood glucose level calculated during the calibration period with the light amount and the number of repetitions used in the normal measurement period and the blood glucose level measured with the invasive blood glucose measuring apparatus. Therefore, it is possible to provide a non-invasive living body information measuring apparatus with low power consumption and short measurement time, which is useful for improving the continuous measurement time of portable devices.

The figure which shows the system configuration | structure in Embodiment 1 of this invention. The figure which shows the block configuration of the noninvasive blood glucose measuring device 101 by Embodiment 1 of this invention. The figure which plotted the estimated blood glucose level 72 of the noninvasive blood glucose measuring device 101 in Embodiment 1 of this invention on the time-axis Enlarged view from time 0 to 20 minutes in which the blood glucose level and the estimated blood glucose level 72 of the invasive blood glucose measurement device 101 and the non-invasive blood glucose measurement device 101 according to Embodiment 1 of the present invention are plotted on the time axis. The figure which shows the system configuration | structure in Embodiment 2 of this invention. The figure which shows the block configuration of the noninvasive blood glucose measuring device 101 by Embodiment 2 of this invention. The figure which plotted the estimated blood glucose level 72 of the noninvasive blood glucose measuring device 101 in Embodiment 2 of this invention on the time axis

Explanation of symbols

21 Voltage signal 31 Amplified signal 41 Sampling data 51 Stored data 61 Feature quantity 71 Light quantity instruction signal 72 Estimated blood glucose level 73 Light quantity restoration signal 81 Light quantity 82 Lighting timing 83 Start-up signal 84 End signal 91 Blood glucose measurement information 101 Non-invasive blood glucose measurement apparatus 102 Living body surface 103 Light 104 Blood vessel 105 Photoacoustic wave signal 201 Light source 202 Biometric information sensor 203 Amplifying means 204 A / D conversion means 205 Storage means 206 Feature quantity detection means 207 Blood glucose level estimation means 271 Light quantity selection means 273 Light quantity appropriateness confirmation means 272 Estimated error register A
274 Proper error register A
275 Blood glucose threshold register for calibration 208 Control means 281 Light quantity change means 285 Light quantity regular confirmation means 282 Minimum light quantity register 283 Increase light quantity register 284 Maximum light quantity register 286 Confirmation cycle register A
287 Confirmation light quantity register 401, 402 Approximate curve 601 Blood glucose level estimation means 611 Repeat count selection means 612 Estimation error register B
613 Repeatability check means 614 Appropriate error register B
615 Repeat count instruction signal 616 Repeat count restore signal 701 Control means 711 Repeat count change means 712 Minimum repeat count register 713 Increase repeat count register 714 Maximum repeat count register 715 Repeat count regular check means 716 Check cycle register B
717 Confirmation repeat count register

Claims (20)

In a non-invasive living body information measuring device for calibrating a blood glucose level measured by a non-invasive blood glucose measuring device using a blood glucose level measured by an invasive blood glucose measuring device,
At least one light source;
Control means for controlling the light quantity and lighting timing of the light source and activation of each means described later;
A biological information sensor for measuring biological information for a predetermined time;
Amplifying means for amplifying an output signal from the biological information sensor;
A / D conversion means for A / D converting the amplified signal;
Storage means for storing the A / D converted digital data;
Feature quantity detection means for analyzing the digital data stored in the storage means and calculating the feature quantity of biological information;
A blood sugar level estimating means for obtaining an estimated blood sugar level from the characteristic amount calculated by the feature amount detecting means and the blood sugar level measured by the invasive blood sugar measuring device;
During the calibration period, the non-invasive blood glucose measurement device performs measurement with a plurality of light amounts, and a plurality of estimated blood glucose values are calculated from the plurality of feature amounts calculated with the respective light amounts and the blood glucose levels measured with the invasive blood glucose measurement device. A value is calculated, and at the end of the calibration period, the blood glucose level measured by the invasive blood glucose measurement device is compared with the plurality of estimated blood glucose levels, and the measurement of the normal measurement period is performed with the light quantity of the estimated blood glucose level that is the closest result A noninvasive living body information measuring device characterized by that. The noninvasive living body information measuring device according to claim 1,
The blood glucose level estimation means calculates an average error by comparing the blood glucose level measured by the invasive blood glucose measurement device and the plurality of estimated blood glucose levels, the average error is equal to or less than a preset threshold value, and A non-invasive living body information measuring device comprising a light amount selection means for detecting the smallest light amount. The noninvasive living body information measuring device according to claim 2,
The non-invasive living body information measuring apparatus according to claim 1, wherein the light amount selecting means includes a register writable from the outside, and the threshold value can be changed according to a value of the register. The noninvasive living body information measuring device according to claim 1,
The non-invasive living body information measuring apparatus according to claim 1, wherein the control means includes a light quantity changing means, and controls the light quantity in accordance with a light quantity instruction signal output from the blood sugar level estimating means. The noninvasive living body information measuring device according to claim 4,
The non-invasive living body information measuring device characterized in that the light amount changing means includes at least one first register group writable from the outside, and can change a light amount value according to the light amount instruction signal. . The noninvasive living body information measuring device according to claim 1,
The control means includes a light quantity periodic confirmation means, and changes the light quantity to a preset value and outputs the light source at a preset period for the light source during a normal measurement period. A non-invasive living body information measuring device. The noninvasive living body information measuring device according to claim 6,
The non-invasive biological information measuring apparatus according to claim 1, wherein the light quantity periodic confirmation means includes a register writable from the outside, and can change a cycle of changing the light quantity according to a value of the register. The noninvasive living body information measuring device according to claim 6,
The non-invasive biological information measuring apparatus according to claim 1, wherein the light quantity periodic confirmation means includes a register writable from the outside, and the value of the light quantity can be changed according to a value of the register. The noninvasive living body information measuring device according to claim 6,
The blood glucose level estimation means includes a light quantity appropriateness confirmation means, and measures the estimated blood sugar level measured with the light quantity changed by the light quantity regular confirmation means and the light quantity set before being changed by the light quantity regular confirmation means. The estimated blood glucose level is compared to calculate an error, and it is determined whether the error is less than or equal to a preset threshold value. If the error is less than or equal to a preset threshold value, A noninvasive living body information measuring device which outputs a light quantity restoration signal so that it may return to the light quantity set before it was changed by light quantity regular check means. The noninvasive living body information measuring device according to claim 9,
The non-invasive biological information measuring apparatus according to claim 1, wherein the light quantity appropriateness confirmation means includes a register writable from outside, and the threshold value can be changed according to a value of the register. In a non-invasive living body information measuring device for calibrating a blood glucose level measured by a non-invasive blood glucose measuring device using a blood glucose level measured by an invasive blood glucose measuring device,
At least one light source;
Control means for controlling the light quantity and lighting timing of the light source and activation of each means described later;
A biological information sensor for measuring biological information for a predetermined time;
Amplifying means for amplifying an output signal from the biological information sensor;
A / D conversion means for A / D converting the amplified signal;
Storage means for storing the A / D converted digital data;
Turn on the light source, repeat a series of operations until the digital data is stored in the storage means a predetermined number of times, average the digital data for a predetermined number of times stored in the storage means,
A feature amount detection means for analyzing the averaged data and calculating a feature amount of biological information;
A blood sugar level estimating means for obtaining an estimated blood sugar level from the characteristic amount calculated by the feature amount detecting means and the blood sugar level measured by the invasive blood sugar measuring device;
In the calibration period, the series of operations in the non-invasive blood glucose measurement device is performed at a plurality of repetitions, and the plurality of feature amounts calculated at the respective repetitions and the blood glucose level measured by the invasive blood glucose measurement device are used. A plurality of estimated blood glucose levels are calculated, and at the end of the calibration period, the blood glucose level measured by the invasive blood glucose measuring device is compared with the plurality of estimated blood glucose levels, and the number of repetitions of the estimated blood glucose level that is the closest result is A noninvasive living body information measuring device characterized by performing measurement of a measuring period. The noninvasive living body information measuring device according to claim 11,
The blood glucose level estimation means calculates an average error by comparing the blood glucose level measured by the invasive blood glucose measurement device and the plurality of estimated blood glucose levels, the average error is equal to or less than a preset threshold value, and A non-invasive living body information measuring device comprising: a repetition number selection means for detecting the smallest number of repetitions. The noninvasive living body information measuring device according to claim 12,
The non-invasive biological information measuring apparatus according to claim 1, wherein the repetition number selecting means includes a register writable from the outside, and the threshold value can be changed according to a value of the register. The noninvasive living body information measuring device according to claim 11,
The non-invasive living body information measuring apparatus according to claim 1, wherein the control means includes a repetition number changing means, and controls the number of repetitions according to a repetition number instruction signal output from the blood sugar level estimation means. The noninvasive living body information measuring device according to claim 14,
The non-invasive living body characterized in that the repetition number changing means includes at least one first register group writable from the outside, and can change the value of the repetition number according to the repetition number instruction signal. Information measuring device. The noninvasive living body information measuring device according to claim 11,
The control means includes a repeat count periodic confirmation means, and changes the lighting timing to a preset number of repeats at a preset cycle and outputs the light source to the light source during a normal measurement period. Non-invasive living body information measuring device characterized. The noninvasive living body information measuring device according to claim 16,
The non-invasive biological information measuring apparatus according to claim 1, wherein the repeat count periodic confirmation means includes a register writable from the outside, and can change a cycle for changing the repeat count according to a value of the register. The noninvasive living body information measuring device according to claim 16,
The non-invasive biological information measuring device according to claim 1, wherein the repeat count periodic confirmation means includes a register writable from the outside, and the value of the repeat count can be changed according to a value of the register. The noninvasive living body information measuring device according to claim 16,
The blood glucose level estimation means includes a repeat count appropriateness confirmation means, and is set before the estimated blood glucose level measured at the repeat count changed by the repeat count periodic check means and before being changed by the repeat count regular check means. Calculating an error by comparing the estimated blood glucose level measured by the number of repetitions, determining whether the error is less than or equal to a preset threshold value,
If the error is less than or equal to a preset threshold value, a repeat count restoration signal is output to the control means so as to return to the repeat count set before being changed by the repeat count periodic confirmation means. A noninvasive living body information measuring device characterized by the above. The noninvasive living body information measuring device according to claim 19,
The non-invasive biological information measuring device according to claim 1, wherein the repeat count appropriateness checking means includes a register writable from outside, and the threshold value can be changed according to a value of the register.

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