JP2008266223A - Chillability improving composition - Google Patents

Abstract

[PROBLEMS] To be easily ingested, excellent in safety and productivity, and inexpensive, yet having a high cooling effect, and by improving the cooling property, various symptoms associated with the cooling property ( Providing a composition having an effect of improving stiff shoulders, low back pain, constipation, discomfort, abnormal urination, abnormal defecation, swelling, hypotension, anemia, etc.
A composition for improving cooling properties, comprising a extract of red pepper, an extract of red pepper, iron and ubiquinone. Further, vitamin C and vitamin B12 may be contained. The composition is a pharmaceutical composition or a food form.
[Selection figure] None

Description

  The present invention relates to a composition for improving cooling properties, which is highly safe and can be easily ingested.

  Coldness is a symptom in which the limbs and lower back are felt cold, and it is said that many women are suffering from coldness, and in recent years, men are increasingly complaining of coldness. Several reasons are considered as the cause of coldness, and it is thought that it becomes easy to become coldness especially when there are many states in which body heat production decreases. In recent years, air-conditioning facilities have rapidly penetrated and the room temperature has become constant regardless of the season, but the temperature difference between the inside and outside of the room is large, so it is subject to sudden temperature changes every time you enter and exit the room. became. For this reason, it has been pointed out that the function of nerves that sense the temperature of the skin surface is reduced, and information about the temperature is not normally transmitted to the brain. As a result, the body's ability to adapt to the season is also reduced by adjusting the body temperature, and by continuing to live in such a sudden temperature difference, the function of the neurotransmission system to adapt to changes in temperature is also reduced. It is said that there is a cold symptom due to abnormal body temperature regulation. Furthermore, when the body temperature decreases, a vicious cycle occurs in which the ability to produce body heat decreases, and the coldness is not cured. Other diseases (stiff shoulders, back pain, constipation, discomfort, abnormal urination, abnormal stool, swelling, hypotension, anemia) Etc.).

  As a method of dealing with such coldness, bathing that warms the body from the outside, moderate exercise such as jogging that warms from the inside, taking herbal medicine, ingesting foods that warm the body such as root vegetables, ginger and green onions are effective. It is said that there is. However, awareness of coldness occurs in various situations, and there has never been a simple method for improving coldness.

  Exercise has the effect of enhancing cardiac function, improving blood flow and spreading the blood throughout the body, and increasing the amount of muscle and increasing the production of body heat as the basal metabolic rate increases. However, it is difficult to continue exercising, and the amount of exercise in daily life inevitably decreases in desk work.

  It is known that ginger, green onions, garlic, chili peppers, etc. are strong foods that warm the body. Furthermore, root vegetables such as konjac and burdock, miso, soy sauce and salt are said to warm the body. These foods have the effect of increasing body temperature due to vasodilation and the promotion of burning of body fat. However, it is difficult for these foods to continuously take the necessary amount for improving the coldness.

  In addition to the methods based on the usual dietary attention as described above, various methods for improving the cooling property have been proposed.

  For example, Patent Document 1 discloses a cooling property improving agent and a functional food containing a plum extract as an active ingredient. This agent and food are said to improve peripheral blood flow and be useful for improving cold.

  Patent Document 2 discloses a medicinal seasoning nutritional food consisting of a combination of six or more selected from hawthorn, keihi, fennel, turmeric, shrimp, ginkgo, wolfberry, capsicum, sesame, ginger and mulberry. . This food is said to be effective in preventing high blood pressure, high cholesterol, diabetes, and the like, as well as preventing female coldness and obesity.

  Patent Document 3 describes a coldness-improving agent containing an extract of a palm tree of the family Pepperaceae as an active ingredient. Ginkgo biloba leaves, safflower, ginger, chili, winter summer grass, plum meat, ginseng, garlic, viper , Egg yolk oil, dokudami, mugwort, field carrot, elephant kogi, mugwort, touki, senkyu, cinnamon, nicke, kudu, leek, leek, onion, lotus root, carrot, sesame, seaweed, wakame, pumpkin, burdock, radish, cabbage, A composition for improving cooling properties by using in combination with one or more materials selected from the group consisting of red beans, grapes, mandarin oranges, eggs, chicken, beef, cheese, sanma, shrimp, vitamin B1, vitamin E, ubiquinone and iron Is disclosed.

JP 2006-348001 A JP-A-11-243913 Japanese Patent Laid-Open No. 2003-40788

  An object of the present invention is to provide a composition that can be easily ingested, is excellent in safety and productivity, is inexpensive, and has a high effect of improving coldness. Furthermore, the present invention provides a composition having an effect of improving various cold symptoms such as stiff shoulders, low back pain, constipation, discomfort, abnormal urination, abnormal defecation, swelling, hypotension, anemia, etc. There is.

  As a result of searching for natural materials that can improve the cooling property, the inventors of the present invention have significantly improved the cooling property even when a small amount of ingestion is obtained by combining the composition of hihatsu extract, red pepper extract, iron and ubiquinone as active ingredients. The present inventors have found that this can be done and have completed the present invention.

That is, the present invention includes the following inventions.
(1) A composition for improving cooling properties, comprising a extract of red pepper, an extract of red pepper, iron and ubiquinone.
(2) The composition for improving cooling properties according to (1), further comprising vitamin C and vitamin B12.
(3) The composition according to (1) or (2), which is a pharmaceutical composition.
(4) The composition according to (1) or (2), which is in the form of food.

  The composition for improving chilliness combining the extract of red pepper, capsicum extract, iron and ubiquinone as active ingredients of the present invention is highly safe, improves chillability, and has the effect of improving various subjective symptoms due to chilliness. Have. The composition for improving chilliness of the present invention can be easily ingested anytime and anywhere, the effect can be obtained in a short time, high safety, and effective in improving various symptoms caused by chilliness and chilliness. is there.

  Hereinafter, the cooling property improving composition (cooling property improving agent) of the present invention will be described. The degree of coldness and the improvement effect are based on the method of measuring the recovery of skin surface temperature by applying a low temperature load to the hands and feet, measuring the blood flow, and measuring the blood flow, and the actual feeling of coldness in daily life or when taking a bath. And a method of scoring subjective symptoms.

  Although the cause of coldness has been studied from various viewpoints, it has been pointed out that the ratio of awareness of coldness is higher in women: male: female = 3: 7. There are many reasons for women compared to men, because changes in female hormones are likely to cause autonomic malfunction, and subcutaneous fat is difficult to pass through heat and it is difficult to warm once cooled, so women with more subcutaneous fat than men It is easier to cool, muscle is a body heat-producing organ that burns fat, but women with less muscle mass than men have less heat production by muscles, and the blood pumping function by muscles is weak, so blood flow Are likely to be stagnant, and women are more likely to feel cold due to differences in clothing.

  Hihatsu (Pepper longum) is a pepper family plant distributed in Southeast Asia and is used as a spice. In the present invention, the cherries extract includes cherries juice, solvent extracts, and dried and purified products thereof. As the hihatsu, any part such as fruit ears, roots, leaves, stems and flowers can be used. Hibatsu juice can be obtained by squeezing the above part using a known method such as a hammer mill or a stone mill.

  As a method for preparing a solvent extract of hihatsu, a known method can be used, for example, a method in which all or any part of hihatsu is immersed in an extraction solvent and stirred or refluxed, and a supercritical fluid extraction method And so on.

  Examples of the extraction solvent include water, an aqueous solution, an organic solvent, and a water-containing organic solvent. Specific examples of the organic solvent include liquids at room temperature such as lower alcohols such as methanol, ethanol, n-propanol, isopropanol, and n-butanol, and polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, and glycerin. Examples thereof include: alcohols such as diethyl ether and propyl ether; esters such as butyl acetate and ethyl acetate; ketones such as acetone and ethyl methyl ketone; hexane; and chloroform. These may be used alone or in combination of two or more. As the extraction solvent, a water-containing organic solvent in which an aqueous component is further contained in the organic solvent may be used. In this case, examples of the aqueous component include water and an aqueous solution of a water-soluble component.

  The extraction operation is as follows: raw chicks, those cut into small pieces, dried chicks, those returned using water or hot water, or dried chicks were pulverized by processing such as crushing or grinding. A thing etc. can be implemented by extracting using the above extraction solvents. The extraction operation can also be performed by a supercritical fluid extraction method using carbon dioxide or the like. Next, the mixture containing the extract and the residue is subjected to filtration or centrifugation as necessary to remove the solid component as a residue to obtain an extract. The removed solid component can be used again for the extraction operation, and this operation may be repeated several times.

  The extract obtained in this way may be used as it is as a Hihatsu extract, and further, if necessary, added with excipients, etc., and dried or powdered by a method such as concentration or freeze-drying or spray-drying. You may use it as an extract of Hibatsu. In the case of drying the extract, any specific drying method may be used as long as it is performed under conditions that do not cause denaturation or thermal decomposition of the extract of cherries. For example, if necessary, an excipient is added, and filtration, centrifugation, centrifugal filtration, spray drying, spray cool, drum drying, vacuum drying, freeze drying, and the like can be mentioned. These methods can be used alone or Can be used in combination. A commercial product (hihatsu extract powder MF; Maruzen Pharmaceutical) can also be used as the hihatsu extract.

  In the composition of the present invention, the content of the extract of the cherries varies depending on the degree of purification of the extract, and can be appropriately set according to the form, use and expected effect of the composition of the present invention. Although it does not restrict | limit, it is 0.1-70 mass parts normally in 100 mass parts of compositions on the basis of dry mass, Preferably it is 0.5-60 mass parts, More preferably, it is 1-50 mass parts.

  Pepper is a pungent plant that is widely eaten as a spice. Red pepper (Capcisum annuun L. var. Fasciculatum) used as a hawk's claw, chimney or shichimi pepper, or red pigment (C. furutescens), chili pepper (C. furutescens) used in tabasco, etc. C. annuum L. var. Grossum). In the present invention, the pepper extract includes squeezed pepper juice, solvent extract, and dried and purified products thereof. As the pepper, any part such as a fruit, a root, a leaf, a stem and a flower can be used. In the present invention, the red pepper extract can be obtained in the same manner as the Japanese extract. Moreover, a commercial item (a chili extract; Nippon Shinyaku) can also be used for a pepper extract.

  In the composition of the present invention, the content of the pepper extract varies depending on the degree of purification of the extract, and can be appropriately set according to the form, use and expected effect of the composition of the present invention. Although it does not restrict | limit, it is 0.01-30 mass parts normally in 100 mass parts of compositions on the basis of dry mass, Preferably it is 0.1-25 mass parts, More preferably, it is 0.5-20 mass parts. Since the pepper extract has a strong pungent taste, it is preferable to appropriately adjust the content of the pepper extract in accordance with the dosage form and the palatability when the composition of the present invention is ingested.

  Iron is an important mineral, and in mammals, it constitutes hemoglobin, which is a major component in red blood cells. When iron is deficient, normal red blood cells are deficient, which may cause anemia, or the blood flow may stagnate, resulting in uneven temperature distribution throughout the body.

  Since iron is a metal, its absorbability is poor as it is, and it can be made into fine powders to increase the absorbency, salt and ionic forms, for example, salts with organic acids such as iron citrate and ferric pyrophosphate, sulfuric acid It is preferable to use a salt with an inorganic acid such as ferric iron and an iron halide such as iron chloride. Such products are commercially available and may be used. Alternatively, iron (heme iron) bound to hemoglobin, or enzyme-treated heme iron bound to a peptide or the like may be used.

  In the composition of the present invention, the iron content can be appropriately set according to the form, use, and expected effect of the composition of the present invention, and is not particularly limited. In 100 mass parts of a thing, it is 0.01-40 mass parts normally, Preferably it is 0.05-30 mass parts, More preferably, it is 0.1-20 mass parts.

  In the present invention, ubiquinone is a substance also called coenzyme Q, vitamin Q or the like. Among them, coenzyme Q10 is also referred to as coenzyme Q10 or ubidecalenone, and is a drug that is used clinically as a metabolic cardiotonic drug, has an energy producing action, is highly safe, and has long been a health food in the United States. It is used as. Even in Japan, since 2001, it has not been judged as a pharmaceutical product unless it has a medicinal effect, and it can be used as a food.

  Ubiquinone is a fat-soluble substance that has low absorbency, but has been processed into a water-soluble composition, and the use of such water-soluble ubiquinone increases the absorption of ubiquinone. The effect can be further enhanced, which is preferable. Examples of the water-soluble ubiquinone include a composition obtained by emulsifying and dispersing ubiquinone in a water-soluble substance in the presence of an organic acid and drying it as necessary (see Japanese Patent Publication No. 2004-242508), octenyl succinate starch A composition obtained by dispersing and emulsifying coenzyme Q10 in an aqueous liquid containing glycerin as a polyhydric alcohol and a water-soluble substance consisting of glycine and dextrin (see WO 2006/022187 International Publication Pamphlet) ) And the like. In the present invention, commercially available water-soluble coenzyme Q10 (Nisshin Pharma; Aqua Q10-P5, Aqua Q10-P40, etc.) may be used as the ubiquinone.

  In the composition of the present invention, the content of ubiquinone can be appropriately set according to the form, use and expected effect of the composition of the present invention, and is not particularly limited. In 100 mass parts of thing, it is 0.01-60 mass parts normally, Preferably it is 0.1-50 mass parts, More preferably, it is 0.5-40 mass parts.

  Patent Document 3 discloses a composition for improving cooling properties, which uses an extract of a pepper of a pepper family Pepper plant as an active ingredient and further uses other ingredients in combination. Ginkgo biloba dry extract and mugwort dry extract have been studied as other components to be used in combination with the extract of Hihatsu. Although the amount of the extract of Hihatsu used in combination can be reduced, the effect of improvement is not as high as that of Hihatsu alone, and the combined effect of other components other than ginkgo biloba and mugwort is not disclosed.

  On the other hand, when the composition of the present invention blended with a jade extract, capsicum extract, iron and ubiquinone is used, a remarkable effect of improving coldness that is immediate and lasts for a long time can be obtained. As a result, it is possible to obtain an excellent effect of improving the cooling property as compared with the case where the extract of the cherries is taken alone. And by effectively improving the cooling property, various symptoms associated with the cooling property can also be improved. Accordingly, in one embodiment, the present invention relates to a method for improving cooling, comprising administering a jade extract, a red pepper extract, iron and ubiquinone to a mammal.

  The above-mentioned extract of pepper, capsicum extract, iron and ubiquinone are all components used as food, and the composition of the present invention can be widely provided not only as a pharmaceutical composition but also as a food. . Therefore, it is also useful for application to improvement of general coldness, which is not a disease. That is, the form of the cooling property improving composition of the present invention is not particularly limited, and can be prepared, for example, as a pharmaceutical composition or as a food (including feed).

  In the present invention, the improvement of chilliness includes improvement of a disease associated with chilliness, and includes healing of symptoms, improvement of symptoms, and suppression of progression of symptoms. Examples of diseases associated with coldness include stiff shoulders, back pain, constipation, discomfort, abnormal urination, abnormal stool, swelling, hypotension, anemia and the like.

  The composition of the present invention can be administered to various animals, and is preferably administered to mammals. Mammals refer to warm-blooded vertebrates, for example, primates such as humans and monkeys, rodents such as mice, rats and rabbits, pets such as dogs and cats, and domestic animals such as cattle, horses and pigs. Is mentioned. The compositions of the present invention are suitable for administration to primates, particularly humans. It is particularly preferred to administer the composition of the present invention to a human who has chilliness or a human who may become cold.

  The composition for improving chilliness of the present invention is 0.01 to 20 g, preferably 0.05, per day for an adult in terms of the total mass of the active ingredients, such as Hihatsu extract, red pepper extract, iron and ubiquinone, based on the dry mass. Administered in the range of -10 g. Since any active ingredient of the composition of the present invention is highly safe used as a food, the dosage can be further increased. It is desirable to increase or decrease the dose appropriately while observing the effects. Although the daily dose can be administered or ingested once, it is desirable to administer the dose in several divided doses.

  When the composition of the present invention is prepared as a pharmaceutical composition, it is usually prepared as a preparation comprising an active ingredient, such as an extract of pepper, a pepper extract, iron and ubiquinone, and a pharmaceutically acceptable carrier. Pharmaceutically acceptable carriers generally refer to inert, non-toxic, solid or liquid, bulking agents, diluents or encapsulating materials that do not react with the active ingredients of the present invention, for example Water, ethanol, polyol (eg, glycerol, propylene glycol, liquid polyethylene glycol, etc.), suitable mixtures thereof, solvents or dispersion media such as vegetable oils, and the like.

  The dosage form of the pharmaceutical composition is not particularly limited, and oral administration forms such as tablets, pills, granules, powders, fine granules, powders, capsules, syrups, drinks, liquids, suppositories, liquid foods, etc. In addition, any dosage form such as a parenteral dosage form such as a sublingual tablet, a nasal spray, or an injection can be used.

  Examples of the administration method of the pharmaceutical composition of the present invention include oral administration and administration methods generally used for pharmaceutical administration, such as intravenous administration, intramuscular administration, transdermal administration, and subcutaneous administration. In addition, it is also possible to adopt an administration method in which it is absorbed from mucous membranes other than the digestive tract, such as the rectum, sublingual, and intranasal. Can be administered.

  The contents of the extract of red pepper, capsicum extract, iron and ubiquinone in the pharmaceutical composition vary depending on the form of the food, but the total mass is usually 0.001 to 100% by mass, preferably 0, based on the dry mass. It is 0.01-80 mass%, More preferably, it is the range of 0.1-60 mass%. In order to achieve the above-mentioned daily intake amount for adults, it is desirable that the daily dose can be controlled. Hibatsu extract, capsicum extract, iron and ubiquinone are highly safe, so their content can be further increased. The daily intake may be taken once, but may be taken in several divided doses.

  When the composition of the present invention is prepared as a food, the form is not particularly limited. The food includes beverages, and includes health foods, foods for specified health use, and functional foods. Health foods, foods for specified health use and functional foods are specifically various types such as tablets, pills, granules, powders, fine granules, powders, capsules, syrups, drinks, liquids, liquid foods, etc. It can be in the form of a preparation. Specific examples of food further include coffee beverages, tea beverages, fruit juice beverages, soft drinks, milk beverages, butter, mayonnaise, shortening, margarine, various salad dressings, breads, noodles, cooked rice, pasta, sauces, Examples include confectionery, cookies, chocolate, candy, chewing gum, various seasonings, and various diet products.

  The composition of the present invention in the form of food includes, in addition to citrus extract, red pepper extract, iron and ubiquinone, other food materials used in the production of the food, various nutrients, various vitamins, minerals, dietary fiber, various Additives (for example, flavoring ingredients, sweeteners, acidulants such as organic acids, stabilizers, flavors) and the like can be blended and manufactured according to conventional methods. You may prepare the composition of the food form of this invention by mix | blending a jade extract, a red pepper extract, iron, and ubiquinone with a normal foodstuff. A food in the form of a preparation can be produced in the same manner as the above pharmaceutical composition. For example, after adding an appropriate excipient (eg, starch, processed starch, lactose, glucose, water, etc.), conventional means are used. Can be used. In addition, since the feed is almost the same as the food except that the subject is other than a person, the description regarding the food in the present specification can be similarly applied to the feed.

  In the composition of the food form of the present invention, the contents of the extract of pepper, capsicum extract, iron and ubiquinone vary depending on the form of the food, but the total mass is usually 0.001 to 80 based on the dry mass. % By mass, preferably 0.01 to 50% by mass, more preferably 0.1 to 20% by mass. Hibatsu extract, capsicum extract, iron and ubiquinone are highly safe, so their content can be further increased. The daily intake may be taken once, but may be taken in several divided doses. It is preferable to use a form that can be managed so that the daily intake per adult can be achieved.

  The composition of the present invention contains one or more components such as other components that improve cooling, such as components that improve blood flow, components that promote metabolism and promote body heat production, components that improve anemia, etc. Can be made. Examples of such components include vitamin C, vitamin E, carnitine, α-lipoic acid, hesperidin, pycnogenol, ornithine, apple polyphenol, hizop, cocoa bean processed product, purple potato extract, Kintoki ginger and copper. The blending ratio of the other components for improving the cooling property can be appropriately set according to the type, the form of the composition, the use, the expected effect, etc., but is not limited at all. The amount is usually 0.01 to 30 parts by mass in 100 parts by mass of the composition of the present invention based on the dry mass.

  In addition to the above components, the composition of the present invention may be further combined with various components (including pharmacologically active components and physiologically active components) as long as the effects of the present invention are not hindered. The kind of such components is not particularly limited, and examples thereof include vitamins, amino acids, organic acids and the like.

  Vitamins include water-soluble vitamins and fat-soluble vitamins. Examples of water-soluble vitamins include vitamin B group and vitamin C. The vitamin B group includes vitamin B1 and its derivatives, vitamin B2, vitamin B6, vitamin B12, orotic acid, and various vitamin B complexes such as biotin, pantothenic acid, nicotinic acid and folic acid. Vitamin B1 and its derivatives include thiamine or salts thereof, thiamine disulfide, fursultiamine or salts thereof, dicetiamine, bisbuthiamine, bisbenchamine, benfotiamine, thiamine monophosphate disulfide, chicotiamine, octothiamine, prosulfur All compounds having bioactivity of vitamin B1 such as thiamine are included. Examples of fat-soluble vitamins include vitamin E, vitamin D or derivatives thereof, vitamin K1, vitamin K2, vitamin A, β-carotene and the like.

  Although the compounding quantity of the said vitamins is not specifically limited, It can set suitably on the basis of the required amount per day for adults (15 years old or older). In addition, these compounding quantities can be increased / decreased suitably according to a use, a dosage form, the kind of compound, the effect anticipated, etc.

  Specific examples of amino acids include alanine, glycine, valine, isoleucine, leucine, cysteine, asparagine, aspartic acid, glutamine, glutamic acid, serine, threonine, and the like. The compounding quantity of amino acids is not specifically limited, It can set suitably.

  Examples of the organic acid include monocarboxylic acids such as fatty acids, dicarboxylic acids such as fumaric acid, maleic acid, tartaric acid, citric acid, lactate, and gluconic acid, and tricarboxylic acids. The compounding amount of the organic acid is not particularly limited, and can be set as appropriate.

  In the composition of the present invention, various additives used in the production of pharmaceuticals, foods, and feeds can be blended, and they may coexist with various active substances. Such additives and active substances include various oils and fats, crude drugs, amino acids, polyhydric alcohols, natural polymers, vitamins, minerals, dietary fibers, surfactants, purified water, excipients, stabilizers, pH adjusters. , Antioxidants, sweeteners, flavoring ingredients, acidulants, colorants, and flavors.

  Examples of the various fats and oils include vegetable oils such as soybean oil, safflower oil, and olive oil, and animal fats such as beef tallow and sardine oil.

  Examples of the herbal medicine include cow yellow, ground yellow, eggplant, royal jelly, carrot and deer.

  Examples of the polyhydric alcohol include ethylene glycol, polyethylene glycol, propylene glycol, glycerin, sugar alcohol and the like. Examples of the sugar alcohol include sorbitol, erythritol, xylitol, maltitol, mannitol and the like.

  Examples of the natural polymer include gum arabic, starch, modified starch, agar, water-soluble corn fiber, gelatin, guar gum, xanthan gum, casein, gluten or gluten hydrolyzate, lecithin, and dextrin.

  Examples of the mineral include calcium, magnesium, zinc, iron and the like.

  Examples of the dietary fiber include gums, mannan, pectin, hemicellulose, lignin, β-glucan, xylan, and arabinoxylan.

  Examples of the surfactant include glycerin fatty acid ester, sorbitan fatty acid ester, and sucrose fatty acid ester.

  Examples of the excipient include sucrose, glucose, corn starch, calcium phosphate, lactose, sorbitol, dextrin, starch, crystalline cellulose, cyclodextrin, and polyvinylpyrrolidone.

  In addition to the above, for example, taurine, glutathione, carnitine, creatine, α-lipoic acid, glucuronic acid, glucuronolactone, theanine, γ-aminobutyric acid, capsaicin, various organic acids, flavonoids, polyphenols, catechins, xanthine derivatives Indigestible oligosaccharides such as fructooligosaccharide, polyvinylpyrrolidone and the like may be added as additives. The amount of these additives is appropriately determined according to the type of additive and the amount of intake to be desired, but is usually 0.01 to 90 parts by mass in 100 parts by mass of the composition of the present invention based on the dry mass. It is.

  As described above, the composition of the present invention not only has an effect of improving the cooling property, but also uses raw materials with food experience, and has high safety. Furthermore, since it does not interfere with the flavor of the food itself even if added to various foods, it can be added to various foods and continuously ingested, improving coldness and various symptoms associated with coldness (stiff shoulders, low back pain, constipation) Discomfort, abnormal urination, abnormal stool, swelling, hypotension, anemia, etc.) are expected to improve.

  The present invention will be described in more detail with reference to the following production examples, examples and test examples, but the present invention is not limited to the following examples.

(Manufacturing Example) 100 g of dried dried ears of Piper longum was extracted by refluxing in 500 mL of hot water at about 90 ° C. for 2 hours. The reflux liquid was filtered to remove insoluble matters, and the mixture was concentrated under reduced pressure until the volume was halved. Dextrin was added to this and powdered by the spray drying method. 5.2 g of Hibatsu extract powder was obtained.

(Example 1) Powder composition Hihatsu extract (hihatsu extract powder MF; Maruzen Pharmaceutical) 500 g, pepper extract (chili extract; Nippon Shinyaku) 200 g, iron (ferric pyrophosphate = 25% iron content) 50 g, coenzyme 250 g of Q10 (aqua Q10-P40 = coenzyme Q10 40% -containing product; Nisshin Pharma) was accurately weighed and mixed using a mixer. A powder that was uniformly mixed and had good fluidity was obtained. This powder readily dissolved in water and ethanol.

(Example 2) Tablets Hihatsu extract (hihatsu extract powder MF; Maruzen Pharmaceutical) 50 mg, Capsicum extract (chili extract; Nippon Shinyaku) 8.3 mg, Iron (ferric pyrophosphate = iron 25% containing product) 26.7 mg , Coenzyme Q10 (Aqua Q10-P40 = Coenzyme Q10 40% product; Nisshin Pharma) 25mg, Vitamin C 30mg, Vitamin B12 10μg, Folic acid 200μg, Reduced maltose 59.8mg, Cellulose 100mg, Agar 20mg The mixture was uniformly prepared by stirring and tableted to obtain a tablet of 320 mg.

(Example 3) 30 mg of the extract from the granule preparation example, 5 mg of pepper extract (chili extract; Nippon Shinyaku), 26 mg of iron (containing ferric pyrophosphate = 25% iron), coenzyme Q10 (Aqua Q10-P40) = Coenzyme Q10 40% content; Nisshin Pharma) 25mg, Folic acid 100µg, Vitamin B12 600µg added and mixed, Orange flavor (orange micron; Takasago) 6.5mg, Yogurt flavor (yogurt micron; Takasago) 4mg, Furthermore, 155 mg of sorbitol and 24.84 mg of sugar ester were mixed as excipients, and 277 mg of granules were obtained by fluidized bed granulation.

(Comparative example)
50 mg of Hihatsu extract (hihatsu extract powder MF; Maruzen Seiyaku), 150 mg of reduced maltose, 100 mg of cellulose and 20 mg of agar as the excipient were mixed and stirred to prepare uniformly and tableted to obtain a tablet of 320 mg. .

(Test Example 1) Test of coldness improving effect The effect of the coldness improving composition of the present invention was examined by a total of 21 men and women who actually feel coldness on a daily basis. 21 tablets of Example 2 once per day, once daily, for 10 consecutive days so that the amount of ingredients is 150 mg of lamb extract, 25 mg of pepper extract, 20 mg of iron and 30 mg of coenzyme Q10. I took it. After the completion of taking the tablets of Example 2, with a 7-day drug holiday, 21 tablets of 3 tablets of Comparative Example 1 were taken once a day, and the daily amount of ingredients was 150 mg As such, it was taken for 10 consecutive days. After the completion of taking the tablets of Example 2 and Comparative Example 1, questionnaires were conducted. As shown in Table 1, each item was related to the coldness and various symptoms associated with coldness, and the score was markedly improved (+2), improved (+1), and invalid (0). The result was a total of 21 scores for each item. Table 2 shows the results of the questionnaire about the subjective symptoms of coldness.

  The number of people who realized the improvement of “cooling of limbs / fingertips” was 15 out of 21 people taking the tablet of Example 2, 10 out of 21 people taking the tablet of Comparative Example 1, and “ The number of people who realized the improvement of “climbing cold” was 12 out of 21 people who took the tablet of Example 2, and 6 out of 21 people who took the tablet of Comparative Example 1. Also, it can be seen that the composition of the present invention exhibits an excellent improvement effect over the comparative example of Hihatsu alone. From Table 2, it can be seen that the cooling property improving composition of the present invention exhibits a very high cooling property improvement effect and further improves various symptoms caused by the cooling property. On the other hand, the comparative example containing only chicks was less effective than the composition of the present invention in any item.

(Test Example 2) Test of temperature recovery effect of the hand The temperature recovery effect of the hand of a woman who feels coldness on a daily basis was examined.
The test was performed on an empty stomach in a room with a room temperature of 24 ° C. and a humidity of 50% so that no stimulant was taken on the day of the test. The subject was rested in the test room, and the test was started after confirming that there was no tension or chills. Three tablets of Example 2 (150 mg of extract of red pepper, 25 mg of pepper extract, 20 mg of iron and 30 mg of coenzyme Q10) were taken with 50 mL of mineral water. After taking 30 minutes, immerse your hand in a wash basin containing water at 24 ° C for 1 minute, lift your hand from the wash basin, wipe off the water droplets, and measure the body surface temperature between the first and second joints of the middle finger of your left hand. Manufactured by Thermo Tracer TH9100). The time when the hands were immersed in water was 0 minute, and after cooling for 1 minute, water droplets were wiped off by 3 minutes, and measurement was performed at 5 minutes and 10 minutes.

  On the next day, in the same manner, instead of the tablet of Example 2, three tablets of Comparative Example 1 (hihatsu extract 150 mg) were taken with 50 mL of mineral water for testing. As a control, measurement was carried out without taking tablets on the day before Example 2. The results are shown in Table 3.

  From Table 3, it can be seen that the composition of the present invention improves finger hypothermia in a very short time.

(Example 4) 40 g of sodium caseinate (DMV), 160 g of maltodextrin (Sanwa starch) and 50 g of the powder obtained in Example 1 were added to 700 g of pure water of about 65 ° C. liquid food and dissolved, and then the vitamin mix And each component mixture of trace mineral was added. The mixed solution was put into a homomixer and roughly emulsified at about 8000 rpm for 15 minutes. The obtained emulsified liquid was cooled to about 20 ° C., and after adding a fragrance, the final volume was increased. After 230 g of this liquid was filled in the pouch, the pouch was sealed while performing nitrogen substitution, and sterilized at 121 ° C. for 15 minutes to obtain a liquid food.

(Example 5) 160 g of bread wheat flour (strong flour) and 2 g of dry yeast were mixed. Separately, 5 g of the powder obtained in Example 1, 25 g of sugar, 3 g of sodium chloride and 6 g of skimmed milk powder were dissolved in 70 g of hot water, and 1 chicken egg was added and mixed well. This was added to the above flour and kneaded by hand, then about 40 g of butter was added and kneaded well to prepare 20 roll bread dough. Next, after fermenting, a beaten egg was applied on the surface and baked in an oven at 180 ° C. for about 15 minutes to prepare a roll. Appearance, taste and texture were good.

(Example 6) After using rice and rice 2go, adding 2g of the powder obtained in Example 1 and seasoning liquid to a general amount of water, cooking rice, and filling this into a retort pack according to a conventional method The mixture was sealed with nitrogen substitution and sterilized at 121 ° C. for 15 minutes to obtain retort rice. Appearance, taste and texture were good.

(Example 7) One serving (150 g) of meat sauce for meat sauce pasta was placed in a pan, and 1 tablet of Example 2 was added thereto and stirred well while warming to completely dissolve. After filling this pouch with a pouch, the pouch was sealed with nitrogen substitution and sterilized at 121 ° C. for 15 minutes to obtain a meat sauce for pasta. Appearance, taste and texture were good.

Claims (4)

  A composition for improving chilliness, comprising a extract of red pepper, an extract of pepper, iron and ubiquinone.   The composition for improving cooling properties according to claim 1, further comprising vitamin C and vitamin B12.   The composition according to claim 1 or 2, which is a pharmaceutical composition.   The composition according to claim 1 or 2, which is in the form of food.