JP2008255069A - Functional food material and method for producing the same - Google Patents
Functional food material and method for producing the same Download PDFInfo
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- JP2008255069A JP2008255069A JP2007101197A JP2007101197A JP2008255069A JP 2008255069 A JP2008255069 A JP 2008255069A JP 2007101197 A JP2007101197 A JP 2007101197A JP 2007101197 A JP2007101197 A JP 2007101197A JP 2008255069 A JP2008255069 A JP 2008255069A
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- Prior art keywords
- carotenoid
- food material
- functional food
- compound
- lutein
- Prior art date
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Abstract
Description
本発明は、生体に対してカロテノイドの吸収性を高められる、つまり生体への吸収性に優れた、そして水に対して澄明に溶解する機能性食品素材とその製造方法に関する。 The present invention relates to a functional food material that can enhance the absorbability of carotenoids to a living body, that is, excellent in absorbability to a living body, and that can be clearly dissolved in water, and a method for producing the same.
上記カロテノイドは優れた抗酸化作用を示し、がんの発症リスクを低減することや白内障、加齢黄斑変性などの疾病予防に効果があるといわれている。 The carotenoids are said to exhibit an excellent antioxidant action, and are effective in reducing the risk of developing cancer and preventing diseases such as cataracts and age-related macular degeneration.
加齢黄斑変性については決め手になるような治療法がまだ開発されていないが、有望な治療法のひとつとして、光感受性物質を静脈内に注入し、その物質と反応しやすい一定波長の半導体レーザーによる活性酸素で新生血管の閉塞を狙う方法が知られている。しかし、手術の技法が難しく、術後に網膜剥離や斜視などの合併症を引き起こすおそれがあり、その意味では開発途上の治療法といえども、健康保険の適用外であることからも問題点が多い。 A decisive treatment for age-related macular degeneration has not yet been developed, but one promising treatment is the injection of a photosensitive substance into a vein and a constant-wavelength semiconductor laser that easily reacts with the substance. There is known a method for aiming at occlusion of a new blood vessel with active oxygen caused by the above. However, the surgical technique is difficult and may cause complications such as retinal detachment and strabismus after the operation. In this sense, even though it is a developing treatment, it is problematic because it is not covered by health insurance. Many.
白内障や加齢黄斑変性などの目の疾病は発症してからでは治療が困難であるので、何らかの形で疾病予防をおこなう必要性があり、特に食品の摂取によりこれらの疾病を予防することは重要とされる。 Since eye diseases such as cataracts and age-related macular degeneration are difficult to treat after onset, there is a need to prevent the disease in some way, and it is particularly important to prevent these diseases by ingesting food. It is said.
従来、白内障や加齢黄斑変性などに有効とされるもののうち、ブルーベリーの飲用が好ましいとされている。つまり、ブルーベリーに含まれるアントシアニンは、パソコンによる目の疲れや、ドライアイ、目のかすみなど現代人の目に関するトラブルに有効とされている。しかし、ブルーベリーの摂取だけでは、白内障や加齢黄斑変性などの重篤な疾病の改善には必ずしも十分ではなく、またこれらの疾病予防に関しても有効とされる根本的な治療方法とはいえない。 Conventionally, among those that are effective for cataracts, age-related macular degeneration, etc., it is considered preferable to drink blueberries. In other words, anthocyanins contained in blueberries are effective for eye problems caused by personal computers, dry eyes, blurred eyes, and other problems related to modern eyes. However, the ingestion of blueberries alone is not always sufficient for the improvement of serious diseases such as cataracts and age-related macular degeneration, and it cannot be said to be a fundamental treatment method effective for the prevention of these diseases.
白内障や加齢黄斑変性などの疾病予防および改善に関して、例えば、ルテインやアスタキサンチンなどのカロテノイド化合物が有効であることが報告されている(例えば、非特許文献1および非特許文献2参照)。 For prevention and improvement of diseases such as cataract and age-related macular degeneration, it has been reported that carotenoid compounds such as lutein and astaxanthin are effective (see, for example, Non-Patent Document 1 and Non-Patent Document 2).
ルテインやアスタキサンチンは、健康な黄斑と網膜のための大切な要因である黄斑色素濃度を高める働きがあり、白内障の発病率が非常に低くなることがわかっている。これらのカロテノイドは野菜や果物に含まれているが、極微量であるため、これらを抽出し、油や有機溶剤で乳化することによって食品や化粧品分野に適用することが報告されている(例えば、特許文献1参照)。 Lutein and astaxanthin work to increase macular pigment concentration, an important factor for healthy macular and retina, and have been found to have a very low incidence of cataracts. These carotenoids are contained in vegetables and fruits, but since they are extremely small, they are reported to be extracted and emulsified with oil or organic solvent to be applied to the food and cosmetic fields (for example, Patent Document 1).
また別の方法としてそれらのカロテノイドを保護コロイドの水溶液と混合し、溶媒成分を水相中に移動させ、カロテノイドなどの疎水相をナノ分散相として生じさせ、更に乾燥粉末の形態とする技術も報告されている(例えば、特許文献2参照)。 Also reported is a technique in which these carotenoids are mixed with an aqueous solution of protective colloid, the solvent component is transferred into the aqueous phase, and a hydrophobic phase such as carotenoid is generated as a nano-dispersed phase, and further in the form of a dry powder. (For example, refer to Patent Document 2).
しかしながら、有機溶剤を用いて抽出されたものは、残留有機溶媒の問題から好ましいとはいえない。またシクロデキストリンで包接することで脂溶性のカロテノイドを水溶性化させる技術が報告されている(例えば、特許文献3参照)。 However, those extracted using an organic solvent are not preferred due to the problem of residual organic solvent. In addition, a technique for making a fat-soluble carotenoid water-soluble by inclusion with cyclodextrin has been reported (for example, see Patent Document 3).
上記の各先行技術を用いて得られるカロテノイドが、はたして速やかに生体に対し吸収されるか否かについては、検証されていない。
そこで、生体に対して吸収に優れたカロテノイドの組成物を得る技術が発明されれば、それを少量摂取するだけで、カロテノイドが効率よく吸収され、白内障や加齢黄斑変性などの疾病予防や改善に対して効果が期待できる。
It has not been verified whether or not carotenoids obtained by using the above-described prior arts can be rapidly absorbed into the living body.
Therefore, if a technique for obtaining a carotenoid composition excellent in absorption for a living body is invented, carotenoids can be efficiently absorbed just by ingesting a small amount thereof, and prevention and improvement of diseases such as cataracts and age-related macular degeneration. Can be expected to be effective.
ところで、本発明者らは、白内障や加齢黄斑変性などの疾病予防および改善に有効とされるカロテノイドを乳化処理することにより、乳化しないカロテノイドに比べて、生体吸収能が著しく向上することを見出した。さらに乳化処理時にレシチンとセラミドを配合するとその効果が更に著しく向上することを確認した。 By the way, the present inventors have found that the bioabsorbability is remarkably improved by emulsifying carotenoids effective in preventing and improving diseases such as cataracts and age-related macular degeneration compared to carotenoids that are not emulsified. It was. Furthermore, when lecithin and ceramide were blended during the emulsification treatment, it was confirmed that the effect was significantly improved.
本発明は上述の点に鑑みなされたもので、白内障や加齢黄斑変性などの疾病予防および改善に有効とされるカロテノイド乳化組成物からなり、生体における吸収性に優れ、かつ安全性が高い機能性食品素材を提供することを目的とする。 The present invention has been made in view of the above points, and is composed of a carotenoid emulsion composition that is effective in preventing and improving diseases such as cataracts and age-related macular degeneration, and has excellent absorbability in the living body and high safety. The purpose is to provide a food material.
本発明は、カロテノイド乳化組成物を錠剤、カプセル、粉末などに適用するサプリメントおよびその原料、あるいはカロテノイドの乳化物を添加することによる、一般食品、化粧品および医薬品として提供することも目的としている。 Another object of the present invention is to provide a supplement for applying a carotenoid emulsified composition to tablets, capsules, powders, and the like and its raw material, or a carotenoid emulsified product as a general food, cosmetic and pharmaceutical product.
上記の目的を達成するために本発明に係る機能性食品素材は、セラミドとレシチンを配合したカロテノイドの乳化組成物からなることを特徴とする。 In order to achieve the above object, the functional food material according to the present invention comprises a carotenoid emulsion composition containing ceramide and lecithin.
請求項2に記載のように、前記カロテノイドは、カロテノイド化合物またはカロテノイド混合物であり、前記カロテノイド化合物は、α−カロテン、β−カロテン、γ−カロテン、δ−カロテン、リコペン、ルテイン、アスタキサンチン、ゼアキサンチン、カンタキサンチン、フコキサンチン、アンテラキサンチン、ビオラキサンチンおよびこれらのエステル体の化合物であり、前記カロテノイド混合物は、前記カロテノイド化合物を溶剤で溶解あるいは懸濁させたもので、これらを含有させたものを含んでいてもよい。 The carotenoid according to claim 2, wherein the carotenoid is a carotenoid compound or a carotenoid mixture, and the carotenoid compound is α-carotene, β-carotene, γ-carotene, δ-carotene, lycopene, lutein, astaxanthin, zeaxanthin, Canthaxanthin, fucoxanthin, anteraxanthin, violaxanthin and their ester compounds, and the carotenoid mixture is a solution obtained by dissolving or suspending the carotenoid compound in a solvent, including those containing these May be.
請求項3に記載のように、前記セラミドが、米、小麦、コーン、蒟蒻由来のいずれかであってもよい。 As described in claim 3, the ceramide may be derived from rice, wheat, corn, or straw.
請求項4に記載のように、前記レシチンが、大豆、卵黄由来のいずれかであってもよい。 As described in claim 4, the lecithin may be one derived from soybean or egg yolk.
請求項5または請求項6に記載のように、前記請求項1〜4のいずれか記載の機能性食品素材を、錠剤、カプセルまたは粉末にしてサプリメントあるいはサプリメントの原料にすることができる。
As described in
請求項7に記載のように、前記請求項1〜4のいずれか記載の機能性食品素材を添加して一般食品、化粧品または医薬品にすることができる。 As described in claim 7, the functional food material according to any one of claims 1 to 4 can be added to make a general food, cosmetic, or pharmaceutical.
上記の目的を達成するために本発明(請求項8)に係る機能性食品素材の製造方法は、カロテノイドに対し、乳化剤と多価アルコール、水、レシチン、セラミド、酸化防止剤を配合し、乳化処理することを特徴とする。 In order to achieve the above object, the method for producing a functional food material according to the present invention (Claim 8) includes emulsifying an emulsifier, a polyhydric alcohol, water, lecithin, ceramide, and an antioxidant with respect to the carotenoid. It is characterized by processing.
請求項9に記載のように、前記カロテノイドは、カロテノイド化合物またはカロテノイド混合物であり、前記カロテノイド化合物は、α−カロテン、β−カロテン、γ−カロテン、δ−カロテン、リコペン、ルテイン、アスタキサンチン、ゼアキサンチン、カンタキサンチン、フコキサンチン、アンテラキサンチン、ビオラキサンチンおよびこれらのエステル体の化合物であり、 前記カロテノイド混合物は、前記カロテノイド化合物を溶剤で溶解あるいは懸濁させたもので、これらを含有させたものを含むものであってよい。 As described in claim 9, the carotenoid is a carotenoid compound or a carotenoid mixture, and the carotenoid compound is α-carotene, β-carotene, γ-carotene, δ-carotene, lycopene, lutein, astaxanthin, zeaxanthin, Canthaxanthin, fucoxanthin, anteraxanthin, violaxanthin and their ester compounds, wherein the carotenoid mixture is a solution obtained by dissolving or suspending the carotenoid compound in a solvent, including those containing these It may be.
請求項10に記載のように、前記カロテノイド化合物または前記カロテノイド混合物を、20〜180℃で乳化処理することが好ましい。
As described in
請求項11に記載のように、前記カロテノイド化合物またはカロテノイド混合物カロテノイドに対し、窒素ガス、炭酸ガス、ヘリウムガス、アルゴンガス等の不活性ガスを通気するか、それらの組成中に抗酸化剤を配合するかすることが好ましい。 The inert gas such as nitrogen gas, carbon dioxide gas, helium gas, argon gas, or the like is blended in the carotenoid compound or carotenoid mixture carotenoid as described in claim 11 or an antioxidant is mixed in the composition. It is preferable to do.
請求項12に記載のように、前記カロテノイド化合物あるいはカロテノイド混合物を加熱溶解させて得られるカロテノイド溶解液に対して、前記乳化剤、前記酸化防止剤、多価アルコール、レシチン、セラミド、水などを配合し、0〜100℃で乳化処理することが好ましい。 The carotenoid solution obtained by heating and dissolving the carotenoid compound or carotenoid mixture according to claim 12 is blended with the emulsifier, the antioxidant, a polyhydric alcohol, lecithin, ceramide, water, and the like. The emulsification treatment is preferably performed at 0 to 100 ° C.
本発明に係る機能性食品素材とその製造方法には、次のような優れた効果がある。 The functional food material and the production method thereof according to the present invention have the following excellent effects.
すなわち、本発明に係る機能性食品素材は、白内障や加齢黄斑変性などの疾病予防および改善に有効であり、しかもレシチンおよびセラミドを含むカロテノイド乳化組成物からなるので、生体における吸収性に優れ、かつ安全性が高い。また、界面活性剤の親水基の割合が高いことから水に対して澄明に溶解する。 That is, the functional food material according to the present invention is effective in preventing and improving diseases such as cataracts and age-related macular degeneration, and is composed of a carotenoid emulsion composition containing lecithin and ceramide. And safety is high. Moreover, since the ratio of the hydrophilic group of surfactant is high, it melt | dissolves clearly with respect to water.
請求項11記載の製造方法によれば、不活性ガスを通気するか、それらの組成中に抗酸化剤を配合することにより、カロテノイドの分解を防ぐことができる。 According to the manufacturing method of Claim 11, decomposition | disassembly of carotenoid can be prevented by ventilating inert gas or mix | blending an antioxidant in those compositions.
以下、本発明に係る機能性食品素材およびその製造方法について実施の形態を説明する。 Embodiments of the functional food material and the method for producing the same according to the present invention will be described below.
カロテノイドは、植物、藻類、細菌類などから、または化学合成して得られるが、本発明の機能性食品素材には、植物、藻類、細菌類などから得られるカロテノイドを使用するのが好ましい。 The carotenoid is obtained from a plant, algae, bacteria, or the like, or obtained by chemical synthesis, and it is preferable to use a carotenoid obtained from a plant, algae, bacteria, etc. as the functional food material of the present invention.
本発明の機能性食品素材としてのカロテノイド乳化組成物において、カロテノイドとはカロテノイド化合物またはカロテノイド混合物であり、カロテノイド化合物とは、α−カロテン、β−カロテン、γ−カロテン、δ−カロテン、リコペン、ルテイン、アスタキサンチン、ゼアキサンチン、カンタキサンチン、フコキサンチン、アンテラキサンチン、ビオラキサンチンなどの化合物で、カロテノイド混合物とはカロテノイド化合物を溶剤で溶解あるいは懸濁させたものをいう。 In the carotenoid emulsion composition as the functional food material of the present invention, the carotenoid is a carotenoid compound or a carotenoid mixture, and the carotenoid compound is α-carotene, β-carotene, γ-carotene, δ-carotene, lycopene, lutein , Astaxanthin, zeaxanthin, canthaxanthin, fucoxanthin, anteraxanthin, violaxanthin and the like, and a carotenoid mixture means a solution obtained by dissolving or suspending a carotenoid compound in a solvent.
本発明の機能性食品素材における溶剤には、動植物油脂、精油成分、脂溶性ビタミン類が用いられる。動植物油脂としては、ヤシ油、オリーブ油、大豆油、ナタネ油、綿実油、椿油、コーン油、ピーナッツ油、紅花油、ヒマワリ油、ゴマ油、シソ油、米油、ヒマシ油、魚油、牛油、豚油、鶏油、中鎖脂肪酸トリグリセライドなどがあげられる。精油成分としては、レモン油、オレンジ油などの柑橘油や、ハッカ、ラベンダー、バラ、ユーカリ、カミツレなどのハーブ類からの精油があげられる。脂溶性ビタミン類としては、ビタミンA、ビタミンD、ビタミンEなどの合成または天然抽出物があげられる。カロテノイドの添加量としては、0.01〜50重量%、好ましくは1〜30重量%の範囲内である。 Animal and vegetable oils and fats, essential oil components, and fat-soluble vitamins are used as the solvent in the functional food material of the present invention. Animal and vegetable oils include coconut oil, olive oil, soybean oil, rapeseed oil, cottonseed oil, coconut oil, corn oil, peanut oil, safflower oil, sunflower oil, sesame oil, perilla oil, rice oil, castor oil, fish oil, cow oil, pork oil Chicken oil, medium chain fatty acid triglycerides and the like. Examples of the essential oil component include citrus oils such as lemon oil and orange oil, and essential oils from herbs such as mint, lavender, rose, eucalyptus and chamomile. Examples of the fat-soluble vitamins include synthetic or natural extracts such as vitamin A, vitamin D, and vitamin E. The amount of carotenoid added is in the range of 0.01 to 50% by weight, preferably 1 to 30% by weight.
HLB(Hydrophile-Lipophile Balance)とは界面活性剤の親油基と親水基の割合を数値化したもので、HLBは高値であれば親水基が多く、HLBが8以上で水分散製剤、11以上で水可溶化製剤となることからここの範囲内にあるとカロテノイドが均一になり、扱いやすい。 HLB (Hydrophile-Lipophile Balance) is a numerical value of the ratio of lipophilic group and hydrophilic group of surfactant. If HLB is high, there are many hydrophilic groups, HLB is 8 or more, water dispersion formulation, 11 or more In this range, the carotenoid is uniform and easy to handle.
また、これらカロテノイドには、エステル類などが結合したものも存在するが、基本骨格がカロテノイド(フリー体)であればエステル類などが結合しているものもカロテノイド化合物を意味するものである(エステル体)。 In addition, some of these carotenoids are bonded with esters, but if the basic skeleton is a carotenoid (free form), those bonded with esters are also carotenoid compounds (esters). body).
本発明のカロテノイド組成物は、ポリグリセリン脂肪酸エステル、ショ糖脂肪酸エステル等の乳化剤と、多価アルコール、水、レシチン、セラミドを配合して乳化処理を行うことにより得られる。使用可能な乳化剤は、HLB値が8以上で、好ましくは11以上である。 The carotenoid composition of the present invention is obtained by blending an emulsifier such as polyglycerin fatty acid ester and sucrose fatty acid ester with a polyhydric alcohol, water, lecithin and ceramide and performing an emulsification treatment. The emulsifier that can be used has an HLB value of 8 or more, preferably 11 or more.
また、これらの乳化剤の複数種を混合して使用することは特に有効であり、本発明においてはポリグリセリン脂肪酸エステルとショ糖脂肪酸エステルを混合して使用しているが、どちらか単独でも本発明の目的を達することが可能である。 In addition, it is particularly effective to use a mixture of a plurality of these emulsifiers, and in the present invention, a polyglycerin fatty acid ester and a sucrose fatty acid ester are mixed and used. It is possible to achieve the purpose.
乳化剤の添加量としては、0.5%〜50重量%、好ましくは2〜20重量%の範囲内である。この範囲内であれば物性的に安定な乳化製剤が得られる。 The amount of the emulsifier added is in the range of 0.5% to 50% by weight, preferably 2 to 20% by weight. Within this range, a physically stable emulsion preparation can be obtained.
多価アルコールは、カロテノイド組成物を安定化するために使用される。一般に、カロテノイドは脂溶性であり、乳化処理によって得られた水可溶性製剤や水分散性製剤は経時的に分離や、カロテノイドの再結晶を起こす可能性がある。また、水分活性が高い状態では腐敗してしまう危険性もあり、多価アルコールを添加することでこれらを回避し、経時的安定性の向上を狙えるものである。 Polyhydric alcohols are used to stabilize carotenoid compositions. In general, carotenoids are fat-soluble, and water-soluble preparations and water-dispersible preparations obtained by emulsification treatment may cause separation or carotenoid recrystallization over time. Further, there is a risk of spoilage in a state where the water activity is high. By adding polyhydric alcohol, these can be avoided and the stability over time can be improved.
使用される多価アルコールは、食品、医薬品、化粧品等の原料として使用されるものであればよい。例えば、グリセリン、ジグリセリン、トリグリセリン、プロピレングリコール、エチレングリコール、グルコース、ソルビトール、マルチトール、マンニトール、キシリトール、キシロース、フラクトース、還元澱粉分解物などがある。また、同様の目的でデキストリン、デンプン、加工デンプンやエタノールなどのアルコール類を用いることも可能である。 The polyhydric alcohol used should just be used as raw materials, such as a foodstuff, a pharmaceutical, and cosmetics. Examples thereof include glycerin, diglycerin, triglycerin, propylene glycol, ethylene glycol, glucose, sorbitol, maltitol, mannitol, xylitol, xylose, fructose, and reduced starch degradation product. For the same purpose, it is also possible to use alcohols such as dextrin, starch, modified starch and ethanol.
レシチンとしては一般的に大豆レシチンが多く使用され、種類としては、ペーストレシチン、分画レシチン、酵素処理レシチン、化学処理されたレシチンが使用されている。また、卵黄レシチンも使用可能で、添加量としては、0.01〜20重量%、好ましくは0.1〜5重量%の範囲内である。この添加量が最も乳化安定性がよく、カロテノイドの生体吸収に優れている。 Soy lecithin is generally used as the lecithin, and paste lecithin, fractionated lecithin, enzyme-treated lecithin, and chemically treated lecithin are used as types. Egg yolk lecithin can also be used, and the amount added is 0.01 to 20% by weight, preferably 0.1 to 5% by weight. This added amount has the best emulsion stability and is excellent in carotenoid bioabsorption.
セラミドには一般的に米セラミド、小麦セラミド、コーンセラミド、蒟蒻セラミドがあるが、いずれのセラミドを使用してもよい。添加量としては、0.01〜10重量%、好ましくは0.1〜5重量%の範囲内である。この添加量が最もカロテノイドの生体吸収に優れている。 Ceramides generally include rice ceramide, wheat ceramide, corn ceramide, and straw ceramide, but any ceramide may be used. The addition amount is 0.01 to 10% by weight, preferably 0.1 to 5% by weight. This added amount is most excellent for the bioabsorption of carotenoids.
また、カロテノイドを安定化させるために酸化防止剤を配合させることが好ましい。利用可能な酸化防止剤としては、天然または合成の酸化防止剤で、合成のdl−α−トコフェロール、BHAやアスコルビン酸、アスコルビン酸ナトリウム、アスコルビン酸パルミチン酸エステル、エリソルビン酸、エリソルビン酸ナトリウムなどがあげられ、天然では抽出トコフェロール、トコトリエノール、ローズマリー抽出物、茶抽出物などがあげられる。 Moreover, it is preferable to add an antioxidant in order to stabilize the carotenoid. Available antioxidants include natural or synthetic antioxidants such as synthetic dl-α-tocopherol, BHA, ascorbic acid, sodium ascorbate, ascorbyl palmitate, erythorbic acid, sodium erythorbate, etc. Naturally, extracted tocopherol, tocotrienol, rosemary extract, tea extract and the like can be mentioned.
混合乳化機としては、ホモジナイザー、ホモミクサー、ホモジェッター、フィルミックス、ハイフレックスミキサー、クレアミックスなどの高速回転型攪拌機、ゴーリン型、ラニエ型などの超高圧式乳化機、ナノマイザー、アルティマイザーなどの高圧衝突型微粒化装置、CLEAR SS5、マスコローダーなどの摩砕型微粒子化装置、ウルトラビスコミル、スターミルなどのビーズミルなどが使用可能である。この他、3本ロールミルや超音波乳化機でも本発明の前記目的に使用することができる。本発明において平均粒径を0.1μm以下、好ましくは0.05μm以下に加工できるものであれば、使用する機器は特に限定されないが、ホモジナイザーもしくはホモミクサーの使用が好ましい。 The mixing emulsifiers include high-speed rotating stirrers such as homogenizers, homomixers, homojetters, fill mixes, high-flex mixers, and Clare mixes, ultra-high-pressure emulsifiers such as Gorin and Lanier types, and high-pressure collisions such as nanomizers and optimizers. A type atomizer, CLEAR SS5, a grinding type atomizer such as a mass loader, a bead mill such as an ultra visco mill, a star mill, or the like can be used. In addition, a three-roll mill or an ultrasonic emulsifier can be used for the object of the present invention. In the present invention, the apparatus to be used is not particularly limited as long as it can be processed to have an average particle size of 0.1 μm or less, preferably 0.05 μm or less, but a homogenizer or a homomixer is preferably used.
本発明のカロテノイド組成物を製造するには、カロテノイド化合物あるいはカロテノイド混合物を加熱溶解させる必要がある。そのために、動植物油脂、精油成分、脂溶性ビタミン類や酸化防止剤を配合することが望ましい。また、乳化剤を配合するのも効果的である。 In order to produce the carotenoid composition of the present invention, it is necessary to heat and dissolve the carotenoid compound or carotenoid mixture. Therefore, it is desirable to blend animal and vegetable oils and fats, essential oil components, fat-soluble vitamins and antioxidants. It is also effective to add an emulsifier.
処理条件はカロテノイドの種類や乳化機の種類により異なるため特に限定されることはないが、低温ではカロテノイドが溶けにくく、高温ではカロテノイドが分解することから、20〜180℃で乳化処理することが好ましい。加熱手段は、特に限定されない。カロテノイドは酸素によって分解されやすく、この際、カロテノイドの分解を防ぐために窒素ガス、炭酸ガス等の不活性ガスを通気することも有効である。 The treatment conditions vary depending on the type of carotenoid and the type of emulsifier, and are not particularly limited. However, since carotenoids are hardly soluble at low temperatures and carotenoids decompose at high temperatures, it is preferable to emulsify at 20 to 180 ° C. . The heating means is not particularly limited. Carotenoids are easily decomposed by oxygen. At this time, it is also effective to ventilate an inert gas such as nitrogen gas or carbon dioxide gas in order to prevent decomposition of carotenoids.
また、組成中に抗酸化剤を配合してカロテノイドの分解を防ぐことも有効である。 It is also effective to mix an antioxidant in the composition to prevent carotenoid decomposition.
カロテノイド化合物あるいはカロテノイド混合物を加熱溶解させて得られるカロテノイド溶解液に対して、前記乳化剤、前記酸化防止剤、多価アルコール、レシチン、セラミド、水などを配合し、0〜100℃で乳化処理することで、本発明のカロテノイド乳化組成物が得られる。本発明品には水が配合されており、0℃以下では凍結し、100℃以上では沸騰乾燥の可能性があることから0〜100℃で乳化処理することが必要である。 Mixing the emulsifier, the antioxidant, the polyhydric alcohol, lecithin, ceramide, water, etc. into the carotenoid solution obtained by heating and dissolving the carotenoid compound or carotenoid mixture, and emulsifying it at 0 to 100 ° C. Thus, the carotenoid emulsion composition of the present invention can be obtained. Since water is mix | blended with this-article product and it freezes at 0 degrees C or less, and there exists a possibility of boiling drying above 100 degrees C, it is necessary to emulsify at 0-100 degreeC.
本発明のカロテノイド乳化組成物は、後記の実施例に示すように、ラットにおける生体吸収促進作用を示した。本生理機能は、実際に動物に与えてその効果を検証したものであり、生体吸収促進はすなわち白内障や加齢黄斑変性などの疾病予防および改善、あるいはその他の機能効果に対して有効な機能性食品素材となり得るものである。 The carotenoid emulsified composition of the present invention exhibited a bioabsorption-promoting action in rats, as shown in the examples below. This physiological function was actually given to animals to verify its effects, and the enhancement of bioabsorption is effective for preventing and improving diseases such as cataracts and age-related macular degeneration, or other functional effects. It can be a food material.
以下、実施例を挙げて本発明を詳細に説明する。なお、本発明は下記の実施例に限定されるものではない。 Hereinafter, the present invention will be described in detail with reference to examples. In addition, this invention is not limited to the following Example.
<実施例1 ルテインの乳化物の製造>
マリーゴールドオイルNo.84790(ルテイン:総キサントフィル含量15% 三栄源エフ・エフ・アイ(株)製)6.7重量%、理研Eオイル600G(トコフェロール含量60% 理研ビタミン(株)製)0.5重量%、リョートーポリグリエステルL−7D(デカグリセリンラウリン酸エステル HLB=17.0 三菱化学フーズ(株)製)3.0重量%、リョートーシュガーエステルS−1670(ショ糖ステアリン酸エステル HLB=16.0 三菱化学フーズ(株)製)3.0重量%を混合し、70℃に昇温後エクセルオートホモジナイザーDX((株)日本精機製作所製)を用いて70℃で8000rpm/min、10分間の混合処理を行った。 この混合液に対して、グリセリン(坂本薬品工業(株)製)55.0重量%、水29.8重量%を加え、70℃に昇温後、エクセルオートホモジナイザーDXを用いて70℃で8000rpm/min、30分間の混合処理を行った。その結果、水に対して澄明に溶解するカロテノイド組成物を得た。
<Example 1 Production of an emulsion of lutein>
Marigold oil no. 84790 (Lutein:
<実施例2 レシチンを配合したルテインの乳化物の製造>
マリーゴールドオイルNo.84790(ルテイン:総キサントフィル含量15% 三栄源エフ・エフ・アイ(株)製)6.7重量%、理研Eオイル600G(トコフェロール含量60% 理研ビタミン(株)製)0.5重量%、リョートーポリグリエステルL−7D(デカグリセリンラウリン酸エステル HLB=17.0 三菱化学フーズ(株)製)3.0重量%、リョートーシュガーエステルS−1670(ショ糖ステアリン酸エステルHLB=16.0 三菱化学フーズ(株)製)3.0重量%を混合し、70℃に昇温後エクセルオートホモジナイザーDX((株)日本精機製作所製)を用いて70℃で8000rpm/min、10分間の混合処理を行った。この混合液に対して、SLPペースト(レシチン:辻製油(株)製)2.0重量%、グリセリン(坂本薬品工業(株)製)5.0重量%、水27.5重量%を加え、70℃に昇温後エクセルオートホモジナイザーDXを用いて70℃で8000rpm/min、30分間の混合処理を行った。その結果、水に対して澄明に溶解するカロテノイド組成物を得た。
<Example 2 Production of an emulsion of lutein containing lecithin>
Marigold oil no. 84790 (Lutein:
<実施例3 セラミド+レシチンを配合したルテインの乳化物の製造>
マリーゴールドオイルNo.84790(ルテイン:総キサントフィル含量15% 三栄源エフ・エフ・アイ(株)製)6.7重量%、理研Eオイル600G(トコフェロール含量60% 理研ビタミン(株)製)0.5重量%、リョートーポリグリエステルL−7D(デカグリセリンラウリン酸エステル HLB=17.0 三菱化学フーズ(株)製)3.0重量%、リョートーシュガーエステルS−1670(ショ糖ステアリン酸エステルHLB=16.0 三菱化学フーズ(株)製)3.0重量%を混合し、70℃に昇温後エクセルオートホモジナイザーDX((株)日本精機製作所製)を用いて70℃で8000rpm/min、10分間の混合処理を行った。 この混合液に対して、SLPペースト(レシチン:辻製油(株)製)2.0重量%、ニップンセラミドRPS(セラミド:日本製粉(株)製)1.0重量%、グリセリン(坂本薬品工業(株)製)55.0重量%、水26.8重量%を加え、70℃に昇温後エクセルオートホモジナイザーDXを用いて0℃で8000rpm/min、30分間の混合処理を行った。 その結果、水に対して澄明に溶解するカロテノイド組成物を得た。
<Example 3 Production of an emulsion of lutein containing ceramide + lecithin>
Marigold oil no. 84790 (Lutein:
<1:ルテインの分析方法>
ルテインには、フリー体ルテインとエステル類などが結合したエステル体ルテインが存在する。これらを定量的に分析するため、高速液体クラマトグラフ(HPLC)を用いた測定法を確立した。カラムには、Develosil C30−UG−5 4.6×250mm(野村化学製)を使用し、移動相には、エタノール:ヘキサン=3:1溶液、波長480nm、流速1ml/minで測定した。フリー体ルテインとエステル体ルテインをそれぞれ分析することができた。この条件で、血中および肝臓中のルテインを定量することができた。
<1: Analysis method of lutein>
Lutein includes ester lutein in which free lutein and esters are bound. In order to analyze these quantitatively, a measurement method using high performance liquid chromatograph (HPLC) was established. Develosil C30-UG-5 4.6 × 250 mm (manufactured by Nomura Chemical) was used for the column, and ethanol: hexane = 3: 1 solution, wavelength 480 nm, flow rate 1 ml / min was used for the mobile phase. Free lutein and ester lutein could be analyzed respectively. Under these conditions, lutein in blood and liver could be quantified.
図1は前記分析法を用いたHPLCによるルテインのクラマトグラムを示す線図である。 FIG. 1 is a diagram showing a chromatogram of lutein by HPLC using the above analytical method.
<2:動物実験によるルテイン化合物の乳化物の生体吸収性>
Sprague Dawley(SD)ラットの雄5週齢を1群5匹で群分けし、さまざまなルテイン化合物およびその乳化物をルテイン濃度で0.02%となるよう飼料に混ぜ、7日間、ラットに自由摂取させた。腹部大動脈より採血して血清中のルテイン含量(図2)と肝臓中に蓄積したルテイン含量(図3)を測定した。検討したルテイン化合物およびその乳化物は次に示した。
<2: Bioabsorbability of emulsion of lutein compound by animal experiment>
Sprague Dawley (SD) rats were grouped into 5 males aged 5 weeks, mixed with various lutein compounds and their emulsions to a concentration of 0.02% lutein, and free to rats for 7 days. Ingested. Blood was collected from the abdominal aorta and the serum lutein content (FIG. 2) and the lutein content accumulated in the liver (FIG. 3) were measured. The studied lutein compounds and their emulsions are shown below.
1)フリー体ルテイン化合物「Lutein Soft Extract」(味の素製)
2)エステル体ルテイン化合物「マリーゴールドオイルNo.84790」(三栄源エフ・エフ・アイ)
3)フリー体ルテイン化合物の乳化物(実施例1)
4)エステル体ルテイン化合物の乳化物(実施例1)
血中および肝臓中のルテイン含量は、フリー体およびエステル体ともに乳化することで、吸収性が有意に向上した(実施例1)。
1) Free Lutein Compound “Lutein Soft Extract” (Ajinomoto)
2) Ester Lutein Compound “Marigold Oil No. 84790” (San-Ei Gen FFI)
3) Emulsion of free lutein compound (Example 1)
4) Emulsion of ester lutein compound (Example 1)
Lutein content in blood and liver significantly improved absorbability by emulsifying both free and ester forms (Example 1).
図2は血清中のルテイン含量を示す棒グラフで、図2中の異なるアルファベットは有意差(p<0.05)を表している。 FIG. 2 is a bar graph showing the lutein content in serum, and the different alphabets in FIG. 2 represent significant differences (p <0.05).
図3は肝臓中のルテイン含量を示す棒グラフで、図3中の異なるアルファベットは有意差(p<0.05)を表している。 FIG. 3 is a bar graph showing the lutein content in the liver. Different alphabets in FIG. 3 represent significant differences (p <0.05).
<3:フリー体ルテインのレシチン配合による生体吸収性の向上>
Sprague Dawley(SD)ラットの雄5週齢を1群5匹で群分けし、フリー体ルテイン化合物、その乳化物およびレシチン配合の乳化物をルテイン濃度で
0.02%となるよう飼料に混ぜ、7日間、ラットに自由摂取させた。腹部大動脈より採血して血清および肝臓ルテイン含量を測定した。肝臓中に蓄積したルテイン含量を図4に示した。検討したルテイン化合物およびその乳化物は次に示している。
<3: Improvement of bioabsorbability by incorporating lecithin of free lutein>
Sprague Dawley (SD) rats, 5 weeks old male, were grouped into 5 groups per group, and free lutein compound, its emulsion and lecithin blended emulsion were mixed in the feed to a lutein concentration of 0.02%, Rats were allowed to ad libitum for 7 days. Blood was collected from the abdominal aorta and the serum and liver lutein contents were measured. The content of lutein accumulated in the liver is shown in FIG. The studied lutein compounds and their emulsions are shown below.
1)フリー体ルテイン化合物「Lutein Soft Extract」(味の素製)
2)フリー体ルテイン化合物の乳化物(レシチンなし)(実施例1)
3)フリー体ルテイン化合物の乳化物(レシチン配合)(実施例2)
1) Free Lutein Compound “Lutein Soft Extract” (Ajinomoto)
2) Emulsion of free lutein compound (no lecithin) (Example 1)
3) Emulsified free lutein compound (containing lecithin) (Example 2)
肝臓中のルテイン含量は、レシチンを配合したフリー体ルテイン化合物の乳化物(実施例2)において吸収性が有意に向上した。 As for the lutein content in the liver, the absorbability was significantly improved in the emulsion of free lutein compound containing lecithin (Example 2).
図4は肝臓中のルテイン含量を示す棒グラフで、図4中の符号*は有意差(p<0.05)、符号**は有意差(p<0.01)をそれぞれ表している。 FIG. 4 is a bar graph showing the lutein content in the liver. In FIG. 4, the symbol * represents a significant difference (p <0.05), and the symbol ** represents a significant difference (p <0.01).
<4:エステル体ルテインのセラミド+レシチン配合による生体吸収性の向上>
Sprague Dawley(SD)ラットの雄5週齢を1群5匹で群分けし、エステル体ルテイン化合物、そのレシチン配合の乳化物およびセラミド+レシチン配合の乳化物をルテイン濃度で0.02%となるよう飼料に混ぜ、7日間、ラットに自由摂取させた。腹部大動脈より採血して血清中のルテイン含量(図5)と肝臓中に蓄積したルテイン含量(図6)を調べた。検討したルテイン化合物およびその乳化物は次に示す。
<4: Improvement of bioabsorbability by mixing ceramide + lecithin of ester lutein>
Sprague Dawley (SD) rats are grouped in groups of 5 males per week, and the ester lutein compound, its lecithin-containing emulsion and ceramide + lecithin-containing emulsion are 0.02% in lutein concentration. It was mixed with the diet and allowed to freely ingest for 7 days. Blood was collected from the abdominal aorta, and the lutein content in the serum (FIG. 5) and the lutein content accumulated in the liver (FIG. 6) were examined. The studied lutein compounds and their emulsions are shown below.
1)エステル体ルテイン化合物「マリーゴールドオイルNo.84790」(三栄源エフ・エフ・アイ)
2)エステル体ルテイン化合物の乳化物(レシチン配合)(実施例2)
3)エステル体ルテイン化合物の乳化物(セラミド+レシチン配合)(実施例3)
肝臓中のルテイン含量は、セラミド+レシチンを配合したエステル体ルテイン化合物の乳化物(実施例3)において吸収性が向上した。
1) Ester Lutein Compound “Marigold Oil No. 84790” (San-Ei Gen FFI)
2) Emulsion of ester lutein compound (containing lecithin) (Example 2)
3) Emulsion of ester lutein compound (ceramide + lecithin combination) (Example 3)
As for the lutein content in the liver, the absorbability improved in the emulsion of the ester lutein compound in which ceramide + lecithin was blended (Example 3).
図5は血清中のルテイン含量を示す棒グラフで、図5中の異なるアルファベットは有意差(p<0.05)を表している。 FIG. 5 is a bar graph showing the lutein content in serum. Different alphabets in FIG. 5 represent significant differences (p <0.05).
図6は肝臓中のルテイン含量を示す棒グラフで、図6中の異なるアルファベットは有意差(p<0.05)を表している。 FIG. 6 is a bar graph showing the lutein content in the liver. Different alphabets in FIG. 6 represent significant differences (p <0.05).
<実施例4:本発明品を含有した飲料>
本発明品を含有した飲料の実施例を次に示している。下記の配合表に示すものを全て混合し、水で50mlとし瓶詰めする。90℃で火入れ殺菌をおこない、放冷することにより飲料を製造できる。本製造方法によりルテインが澄明に溶解した飲料が処方できる。
<Example 4: Beverage containing product of the present invention>
Examples of beverages containing the product of the present invention are shown below. Mix everything shown in the following recipe and make up to 50 ml with water. A beverage can be produced by sterilizing by heating at 90 ° C. and allowing to cool. By this production method, a beverage in which lutein is clearly dissolved can be prescribed.
配合表(50ml中)
1.高果糖液糖 6g
2.エリスリトール 3g
3.クエン酸 0.7g
4.本発明品(実施例3) 0.3g
5.香料 適量
6.クエン酸ナトリウム 適量
7.ローズマリー抽出物 0.025g
8.保存料(安息香酸ナトリウム) 0.015g
9.甘味料(スクラロース) 0.7mg
Recipe (in 50ml)
1. High fructose liquid sugar 6g
2. Erythritol 3g
3. Citric acid 0.7g
4). Product of the present invention (Example 3) 0.3 g
5. Perfume appropriate amount 6. Sodium citrate appropriate amount 7. Rosemary extract 0.025g
8). Preservative (sodium benzoate) 0.015g
9. Sweetener (sucralose) 0.7mg
<実施例5:本発明品を含有した食品(キャンディー)>
本発明品を含有した食品(キャンディー)の実施例を次に示している。還元麦芽水あめを170℃まで加熱し、130℃まで温度が下がったところで、本発明品(実施例例3)を加えて混ぜる。さらに50%クエン酸水をまぜて、すばやく型に流し込む。固まったら型からはずすことにより、キャンディーを製造できる。本製造方法によりルテインが澄明に溶解した食品(キャンディー)が処方できる。
<Example 5: Food (candy) containing the product of the present invention>
Examples of food (candy) containing the product of the present invention are shown below. The reduced malt syrup is heated to 170 ° C, and when the temperature drops to 130 ° C, the product of the present invention (Example 3) is added and mixed. Mix 50% citric acid water and pour it into the mold quickly. Once solidified, the candy can be produced by removing it from the mold. By this production method, a food (candy) in which lutein is clearly dissolved can be formulated.
10〜15個のキャンディーを作る場合の配合
1.還元麦芽水あめ50g
2.50%クエン酸水0.1ml
3.本発明品(実施例例3)0.5g
Formulation for making 10-15 candy Reduced malt syrup 50g
2. 50 ml of 50% citric acid water
3. Product of the present invention (Example 3) 0.5 g
Claims (12)
前記カロテノイド化合物は、α−カロテン、β−カロテン、γ−カロテン、δ−カロテン、リコペン、ルテイン、アスタキサンチン、ゼアキサンチン、カンタキサンチン、フコキサンチン、アンテラキサンチン、ビオラキサンチンおよびこれらのエステル体の化合物であり、
前記カロテノイド混合物は、前記カロテノイド化合物を溶剤で溶解あるいは懸濁させたもので、これらを含有させたものを含むことを特徴とする請求項1に記載の機能性食品素材。 The carotenoid is a carotenoid compound or a carotenoid mixture,
The carotenoid compound is α-carotene, β-carotene, γ-carotene, δ-carotene, lycopene, lutein, astaxanthin, zeaxanthin, canthaxanthin, fucoxanthin, anthaxanthin, violaxanthin and their ester compounds,
The functional food material according to claim 1, wherein the carotenoid mixture is obtained by dissolving or suspending the carotenoid compound with a solvent and containing the carotenoid compound.
前記カロテノイド化合物は、α−カロテン、β−カロテン、γ−カロテン、δ−カロテン、リコペン、ルテイン、アスタキサンチン、ゼアキサンチン、カンタキサンチン、フコキサンチン、アンテラキサンチン、ビオラキサンチンおよびこれらのエステル体の化合物であり、
前記カロテノイド混合物は、前記カロテノイド化合物を溶剤で溶解あるいは懸濁させたもので、これらを含有させたもの含むことを特徴とする請求項8に記載の機能性食品素材の製造方法。 The carotenoid is a carotenoid compound or a carotenoid mixture,
The carotenoid compound is α-carotene, β-carotene, γ-carotene, δ-carotene, lycopene, lutein, astaxanthin, zeaxanthin, canthaxanthin, fucoxanthin, anthaxanthin, violaxanthin and their ester compounds,
The method for producing a functional food material according to claim 8, wherein the carotenoid mixture is obtained by dissolving or suspending the carotenoid compound with a solvent and containing the compound.
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Cited By (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010155815A (en) * | 2009-01-05 | 2010-07-15 | Fujifilm Corp | Astaxanthin-containing dispersion and method for producing the same |
JP2016194971A (en) * | 2015-03-31 | 2016-11-17 | 大日本印刷株式会社 | Packaging material for batteries |
WO2020095881A1 (en) * | 2018-11-05 | 2020-05-14 | Jxtgエネルギー株式会社 | Composition for increasing retention of carotenoid in blood |
JP2022165021A (en) * | 2021-04-19 | 2022-10-31 | 学校法人 名城大学 | Functional food composition and functional food containing cis-form lutein |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000511923A (en) * | 1996-06-12 | 2000-09-12 | ラボラトワール エノビオル | Compositions with sunburn and photoprotective activity and their cosmetic application |
JP2002003390A (en) * | 2000-06-26 | 2002-01-09 | Maruzen Pharmaceut Co Ltd | Fibroblast growth agent, food and drink for beauty culture and skin cosmetic |
JP2002226323A (en) * | 2001-02-02 | 2002-08-14 | Maruzen Pharmaceut Co Ltd | Collagen production promoter, collagenase inhibitor, fibroblast proliferation agent, elastase inhibitor, estrogen-like action agent, skin cosmetic, and beautifying drink or food |
JP2002532389A (en) * | 1998-12-08 | 2002-10-02 | ファレス ファーマシューティカル リサーチ エヌブイ | Phospholipid composition |
JP2005522463A (en) * | 2002-03-13 | 2005-07-28 | コッラジェネックス ファーマシューチカルス インコーポレイテッド | Water based delivery system |
JP2005350445A (en) * | 2004-05-25 | 2005-12-22 | Coletica | Hydrated lamellar phase or liposome containing aliphatic monoamine or cationic polymer that promotes intracellular penetration, cosmetic or pharmaceutical composition containing the same, and screening method for this substance |
-
2007
- 2007-04-07 JP JP2007101197A patent/JP5196833B2/en not_active Expired - Fee Related
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000511923A (en) * | 1996-06-12 | 2000-09-12 | ラボラトワール エノビオル | Compositions with sunburn and photoprotective activity and their cosmetic application |
JP2002532389A (en) * | 1998-12-08 | 2002-10-02 | ファレス ファーマシューティカル リサーチ エヌブイ | Phospholipid composition |
JP2002003390A (en) * | 2000-06-26 | 2002-01-09 | Maruzen Pharmaceut Co Ltd | Fibroblast growth agent, food and drink for beauty culture and skin cosmetic |
JP2002226323A (en) * | 2001-02-02 | 2002-08-14 | Maruzen Pharmaceut Co Ltd | Collagen production promoter, collagenase inhibitor, fibroblast proliferation agent, elastase inhibitor, estrogen-like action agent, skin cosmetic, and beautifying drink or food |
JP2005522463A (en) * | 2002-03-13 | 2005-07-28 | コッラジェネックス ファーマシューチカルス インコーポレイテッド | Water based delivery system |
JP2005350445A (en) * | 2004-05-25 | 2005-12-22 | Coletica | Hydrated lamellar phase or liposome containing aliphatic monoamine or cationic polymer that promotes intracellular penetration, cosmetic or pharmaceutical composition containing the same, and screening method for this substance |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2010155815A (en) * | 2009-01-05 | 2010-07-15 | Fujifilm Corp | Astaxanthin-containing dispersion and method for producing the same |
JP2016194971A (en) * | 2015-03-31 | 2016-11-17 | 大日本印刷株式会社 | Packaging material for batteries |
WO2020095881A1 (en) * | 2018-11-05 | 2020-05-14 | Jxtgエネルギー株式会社 | Composition for increasing retention of carotenoid in blood |
JPWO2020095881A1 (en) * | 2018-11-05 | 2021-10-07 | Eneos株式会社 | Composition for increasing blood retention of carotenoids |
JP2022165021A (en) * | 2021-04-19 | 2022-10-31 | 学校法人 名城大学 | Functional food composition and functional food containing cis-form lutein |
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