JP2008099652A - Health food for metabolic syndrome - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a health food for metabolic syndrome, which not only avoids accumulation of visceral fat from occurring but also has an excellent inhibitory effect on hypertension and is suitably used as a health food without an adverse effect for a long period of time. <P>SOLUTION: The health food for metabolic syndrome comprises powder obtained by grinding a woody portion or leaf portion of kothala himubutu. salacia reticulata being a perennial lianous plant growing naturally only in Sri Lanka or an extract of kothala himubutu. salacia reticulata. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to a health food for metabolic syndrome.

  Metabolic syndrome has been taken up as an important issue recently, but it is a syndrome of postprandial hyperglycemia, serum lipid metabolism abnormalities, and hypertension based on the accumulation of visceral fat. It presents arteriosclerosis and heart disease symptoms and can lead to death. Currently, there are still few therapeutic drugs for metabolic syndrome, and development of preventive drugs and therapeutic drugs is desired.

  On the other hand, Kotala Himubutu (Salacia reticulata) is a perennial vine that grows only in the Democratic Socialist Republic of Sri Lanka, and is classified into the Dechinmuraceae or the Physiaceae family. Although it has long been known locally that the powder obtained by pulverizing the xylem of this plant and the extract decocted thereof are effective in lowering blood sugar, other medicinal effects were unclear (see Non-Patent Document 1). .

  Supervised by Hirokazu Kitamura, edited by Salacia Institute, "Mysterious Salacia Diet", Shiki Publishing, 1999

  Kotara Hinbutu has been known to contain various active ingredients such as Sarasinol and Kotalanol, but has not been studied in detail yet, and further research needs to be conducted.

  The present invention not only prevents the accumulation of visceral fat, but also has an excellent antihypertensive effect and is suitable for use over a long period of time without side effects as a health food. It is to provide.

  The present invention achieves the above-mentioned object, and the invention according to claim 1 contains a powder obtained by pulverizing Kotara Hinbuts into a fine particle or an extract of Kotara Hinbuts, which is a health containing Kotara Hinbuts It is food.

  The present invention can provide a health food that effectively contains various active ingredients of Kotara Hinbutu by efficiently using the various active ingredients contained in Kotara Hinbutu, and is obtained by the present invention. The active ingredient of Kotara Hinbutsu not only can avoid the accumulation of visceral fat, but also has an excellent antihypertensive effect and is suitable for use as a health food for a long period without side effects.

  Kotara Hinbutsu used in the present invention is a special vine plant of the Democratic Socialist Republic of Sri Lanka, and it is desirable to use a dried plant, but it is not limited to this. It is desirable to set the degree of dryness to a moisture content of 10% or less. It is desirable to dry Kota Hinbutu having a moisture content greater than 10%.

  First, the wood part and leaf part of Kotara Hinbuts are pulverized, but this pulverization is preferably performed using a jet mill (jet pulverizer) or the like, but is not limited thereto.

  When using Kontala Himubutu, it is desirable to extract the pulverized product with hot water, but it is desirable to use about 10 to 1000 times as much water as the weight of Kotara Hinbutsu pulverized product, but this is not restrictive. The temperature of the hot water is preferably in the temperature range of 80 ° C. or more and 100 ° C. or less, but it is possible to employ a high temperature under pressure. For the extraction, alcohols and other organic solvents can be used.

  Further, the powder or extract of Kotara Hinbutu of the present invention is used as an additive to foods, but as foods used for health foods, breads, rices, noodles, confectionery, processed marine products, dairy products These are beverages, seasonings, food supplements, etc., which can be mixed with the powder or extract of Kotara Hinbutu of the present invention to make a health food. The powder of Kotara Hinbuts of the present invention can also be used directly as a beverage. In this case, it is desirable to extract the pulverized product with hot water. Although it is desirable to use about twice as much water, it is not limited to this.

Example 1
The fine powder obtained by pulverizing the wood part of Kotara Hinbutu was soaked in water, heated to 80 ° C. and held for 2 hours for extraction treatment. After cooling, the solid content was removed by filtration to obtain a hot water extract. The obtained hot water extract was dried and powdered by adding an equal amount of cyclodextrin to obtain Kotarahim for this study.

  Twenty-four TSOD (Tsumura, Suzuki, Obese, Diabetes) mice, which are spontaneous type 2 diabetes obesity model mice, were used as experimental animals. These mice are 3-week-old male TSOD mice and were obtained from the Institute for Animal Breeding (Ibaraki Prefecture). Mice are raised in a breeding room under a day / night cycle of room temperature 23 ± 2 ° C, humidity 55 ± 10%, 12 hours a day, and freely given powdered diet MF (Oriental Yeast Co., Ltd.) and water for 1 week. After breeding, the animals were switched to the following research breeding from the age of 4 weeks.

  The 24 mice described above were divided into 3 groups of control group, Kotarahim 1% use group (Kotarahim low dose group), Kotarahim 3% use group (Kotarahim high dose group), 8 mice each, Only feed MF, powdered MF and 1.0% Kotarahim mixed feed for the Kotarahim 1% use group, powdered feed MF and 3.0% Kotarahim mixed feed for the Kotarahim 3% use group, respectively And raised for 8 weeks until 12 weeks of age.

  Changes in body weight, food intake, visceral fat mass, subcutaneous fat mass, blood pressure, etc. for the mice in the control group, the 1% use group of Kotarahim, and the 3% use group of Kotarahim at the start of this study Were measured and compared.

About change in body weight The body weight was measured every week from the start of the experiment (week 0) to the end of the experiment (week 8).

２．コタラヒム１％使用群のマウスの体重変動は下記のとおりであった。

３．コタラヒム３％使用群のマウスの体重変動は下記のとおりであった。

1. The change in body weight of the mice in the control group was as follows.

2. The weight fluctuations of the mice in the 1% use group of Kotarahim were as follows.

3. The body weight fluctuations of the mice in the Kotarahim 3% use group were as follows.

  The mice in the control group, the 3% use group of Kotarahim, and the 3% use group of Kotarahim, compared the changes in body weight. As a result, the mice bred with a diet not containing Kotarahim had a large weight gain and became obese. The mice in the Kotarahim 1% use group and Kotarahim 3% use group had little weight gain and were able to prevent becoming obese.

Changes in Visceral Fat Volume and Subcutaneous Fat Volume At the start of the experiment (week 0), 4 weeks, and at the end of the experiment (week 8), the mice were subjected to laboratory animal X under Nembutal anesthesia (50 mg / kg, ip). Visceral fat weight and subcutaneous fat weight were measured by setting the line CT apparatus La Theta (Aloka Co., Ltd.) and scanning from the xiphoid process to the sacrum at 1.5 mm intervals.

２．コタラヒム１％使用群のマウスの内蔵脂肪は下記のとおりであった。

３．コタラヒム３％使用群のマウスの内蔵脂肪は下記のとおりであった。

1. The internal fats of the mice in the control group were as follows.

2. The internal fats of mice in the 1% use group of Kotarahim were as follows.

3. The internal fats of mice in the Kotarahim 3% use group were as follows.

２．コタラヒム１％使用群のマウスの皮下脂肪は下記のとおりであった。

３．コタラヒム３％使用群のマウスの皮下脂肪は下記のとおりであった。

1. The subcutaneous fat of the control group of mice was as follows.

2. The subcutaneous fat of mice in the Kotarahim 1% use group was as follows.

3. The subcutaneous fat of mice in the Kotarahim 3% use group was as follows.

  When the visceral fat and subcutaneous fat were compared in the mice of the control group, the 1% using Kotarahim group, and the 3% using Kotarahim group, the visceral fat and subcutaneous fat were significantly increased in the mice fed with the diet not containing Kotarahim. However, the visceral fat and the subcutaneous fat were hardly increased in the mice in the Kotarahim 1% use group and the Kotarahim 3% use group.

About blood pressure Each mouse after breeding in this study was held in a holding device THC-2 (Softron, Tokyo, Japan) and maintained the body temperature at 37 ° C., while maintaining the body temperature at 37 ° C., a non-invasive blood pressure measuring device BP-98A ( Blood pressure was measured by non-invasive blood pressure insertion into tail cuff of Softtron Co., Ltd. Measurement results of systolic blood pressure, diastolic blood pressure, and average blood pressure are shown.

２．コタラヒム１％使用群のマウスの各血圧は下記のとおりであった。

３．コタラヒム３％使用群のマウスの各血圧は下記のとおりであった。

1. Each blood pressure of the control group mice was as follows.

2. Each blood pressure of the mice in the 1% use group of Kotarahim was as follows.

3. Each blood pressure of the mice in the Kotarahim 3% use group was as follows.

  After comparing the blood pressure of the three groups of mice, the control group, the 1% use group of Kotarahim, and the 3% use group of Kotarahim after breeding in this study, the mice raised on the diet without the addition of Kotarahim had high blood pressure and were in a hypertensive state. However, the mice in the Kotarahim 1% use group and the Kotarahim 3% use group did not have high blood pressure and were in a healthy state.

Claims (1)

  A health food for metabolic syndrome, comprising a powder obtained by pulverizing Kotara Hinbutu into fine particles or an extract of Kotah Hinbutu.