JP2008086605A - Endoscope processor, autofluorescence image display program, and endoscope system - Google Patents

Abstract

An image capable of discriminating a lesion site and a bleeding site in a fluorescence endoscope system is created.
A front-stage signal processing circuit (41) alternately receives a reference light image signal and a fluorescence image signal. The matrix circuit 45 decomposes the image signal into an R signal component, a G signal component, and a B signal component. The RGB signal component is stored in the DRAM 43. The RGB signal components obtained by decomposing the reference light image signal are sent to the ratio producing circuit 46. The ratio calculation circuit 46 calculates G / R and B / R based on the RGB signal components. The determination circuit 47 determines whether or not G / R and B / R are included in the bleeding determination region. Based on the discrimination by the discrimination circuit 47, the pseudo color image calculation circuit 48 creates a pseudo color image in the bleeding estimation region. Further, the pseudo color image calculation circuit 48 creates a reference light image in the non-bleeding region.
[Selection] Figure 2

Description

  The present invention relates to an endoscope processor that creates an image that contributes to the identification of a lesion in an electronic endoscope system using autofluorescence.

  Autofluorescence is known in which a living tissue emits fluorescence by irradiating the living tissue with light (excitation light) having a specific wavelength such as ultraviolet rays. In addition, it is known that the amount of this fluorescent light is low in lesion sites such as cancer cells. An electronic endoscope system using this property is known (see Patent Document 1).

  In this electronic endoscope system, the reference light image when the reference light such as white light is irradiated is compared with the autofluorescence image when the excitation light is irradiated, and the pixel is dark in the autofluorescence image and bright in the reference light image. By performing signal processing for extracting the image and displaying a pseudo color image in which the pixels are colored, it is possible to specify the lesion site.

  In the autofluorescence image, the inner part of the lumen and the concave part are darkly displayed in addition to the lesion part, so that it is difficult to distinguish from the lesion part and it is difficult to specify the lesion part. Therefore, it is easy to specify a region estimated as a lesion site by displaying a pseudo color image colored by extracting pixels as described above.

By the way, since hemoglobin strongly absorbs excitation light and autofluorescence, a bleeding site unrelated to the lesion site is displayed dark in the autofluorescence image and brightly displayed in the reference light image, like the lesion site. Therefore, since such a bleeding site is also colored in the pseudo color image, it is difficult to distinguish between a lesion site and a bleeding site.
Japanese Patent Laying-Open No. 2005-40181

  Therefore, an object of the present invention is to provide an endoscope processor that creates an image for specifying a lesion site based on an autofluorescence image, such as a pseudo color image, in a region other than a region where a bleeding site is displayed. .

  The endoscope processor of the present invention includes an imaging device that generates respective image signals based on optical images of respective subjects irradiated with excitation light or reference light that emits fluorescence when irradiated on a living tissue at different timings. A receiving unit that receives a reference light image signal that is an image signal generated when the reference light is irradiated and a fluorescent image signal that is an image signal generated when the excitation light is irradiated, and forms a reference light image signal A color discriminating unit for identifying a bleeding estimation region estimated as a bleeding site based on a color signal component to be detected inside the imaging region, which is a region captured by the imaging device, and only a non-bleeding region that is an imaging region other than the bleeding estimation region And an image processing unit for generating a lesion estimated image based on the fluorescence image signal.

  Note that the color signal is an R signal component, a G signal component, and a B signal component, and the color determination unit calculates G / R and B / R, which are ratios of signal strengths of the G signal component and the B signal component to the R signal component It is preferable to specify a region where the calculated G / R is within the first range and B / R is within the second range as the bleeding estimation region.

  In addition, it is preferable that the bleeding estimation region is specified by the color determination unit for a region whose luminance is lower than the threshold in the fluorescent image corresponding to the fluorescent image signal.

  Moreover, it is preferable that a lesion part estimation image is created based on a reference light image signal.

  The image processing unit preferably colors the bleeding estimation region in a predetermined color. Alternatively, the image processing unit preferably shades the bleeding estimation area in a predetermined form.

  The pseudo color image creation program according to the present invention includes an imaging device that generates respective image signals based on optical images of respective subjects that are irradiated with excitation light or reference light that emits fluorescence when irradiated on biological tissue at different timings. A drive unit that causes the receiving unit to receive a reference light image signal that is an image signal generated when the reference light is irradiated and a fluorescent image signal that is an image signal generated when the excitation light is irradiated; and a reference light image A color discriminating unit for identifying a bleeding estimation region estimated as a bleeding site based on a color signal forming a signal inside an imaging region which is a region captured by the imaging device, and a non-bleeding which is a photographing region other than the bleeding estimation region An endoscope processor is made to function as an image processing unit that creates a lesion estimated image based on a fluorescence image signal only in a region.

  An endoscope system of the present invention includes a light source unit that emits reference light and excitation light that emits fluorescence when irradiated on a living tissue, a light source control unit that emits excitation light and reference light at different timings, and excitation light. An imaging device that receives an optical image of the subject when the subject is irradiated and generates a fluorescent image signal and receives an optical image of the subject when the reference light is irradiated to generate a reference light image signal; A color discriminating unit for identifying a bleeding estimation region estimated as a bleeding site based on a color signal forming a reference light image signal inside an imaging region, which is a region captured by the imaging device, and an imaging region other than the bleeding estimation region An image processing unit that creates a lesion estimated image based on a fluorescence image signal only in a non-bleeding region, and a monitor that displays the lesion estimated image created in the image processing unit That.

  According to the present invention, it is possible to create a lesion estimated image for estimating a lesion site based on a fluorescence image signal only in a non-bleeding region other than the bleeding estimation region. Therefore, the bleeding site and the lesion site can be easily distinguished.

Embodiments of the present invention will be described below with reference to the drawings.
FIG. 1 is a block diagram schematically showing an internal configuration of an endoscope system having an endoscope processor to which an embodiment of the present invention is applied.

  The endoscope system 10 includes an endoscope processor 20, an electronic endoscope 50, and a monitor 60. The endoscope processor 20 is connected to the electronic endoscope 50 and the monitor 60.

  Illumination light for illuminating the subject is supplied from the endoscope processor 20. The illuminated subject is photographed by the electronic endoscope 50. An image signal generated by photographing with the electronic endoscope 50 is sent to the endoscope processor 20.

  In the endoscope processor 20, predetermined signal processing is performed on the image signal obtained from the electronic endoscope 50. The image signal subjected to the predetermined signal processing is sent to the monitor 60 as a video signal, and an image corresponding to the sent video signal is displayed on the monitor 60.

  The endoscope processor 20 is provided with a light source unit 30, an image processing unit 40, a system controller 21, a timing controller 22, and the like. As will be described later, the light source unit 30 emits illumination light for illuminating the subject. As will be described later, the image processing unit 40 performs predetermined signal processing on the image signal.

  The operation of the entire endoscope processor 20 is controlled by the system controller 21. The timing controller 22 adjusts the operation timing in each part of the endoscope processor 20.

  When the endoscope processor 20 and the electronic endoscope 50 are connected, the light source unit 30 and the light guide 51 provided in the electronic endoscope 50 are optically connected. Further, when the endoscope processor 20 and the electronic endoscope 50 are connected, the image processing unit 40 and the image sensor 52 provided in the electronic endoscope 50 are imaged with the timing controller 22 via the image sensor driving circuit 23. The element 52 is electrically connected, and the system controller 21 and the operation input unit 53 provided in the electronic endoscope 50 are further electrically connected.

  The light source unit 30 includes a light source 31 that emits white light, a condenser lens 32, a light source filter 33, a light source filter drive mechanism 34, and a motor 35. A condensing lens 32 is provided in the optical path for guiding light emitted from the light source 31 to the incident end of the light guide 51. The light emitted from the light source 31 is collected by the condenser lens 32 and is incident on the incident end of the light guide 51.

  The light source filter 33 is supported by the light source filter drive mechanism 34 and can be inserted into and removed from the optical path of the light source 31. The light source filter 33 is inserted into and removed from the optical path of the light source 31 by driving the motor 35. The drive of the motor 35 is controlled by the system controller 21.

  The light source filter drive mechanism 34 is provided with a position detection sensor 36, and the position of the light source filter 33 is detected by the position detection sensor 36. Further, the position of the light source filter 33 detected by the position detection sensor 36 is sent to the system controller 21. Based on the position of the light source filter 33, the drive of the motor 35 is controlled by the system controller 21 as described above.

  The light source filter 33 is formed of a member that absorbs the red light component in the irradiated light and transmits the blue and green light components. Therefore, when the light source filter 33 is inserted into the optical path of the light source 31, excitation light that is a blue or green partial light component or ultraviolet component of white light is incident on the incident end of the light guide 51. On the other hand, when the light source filter 33 is separated from the optical path of the light source 31, white light is incident on the incident end of the light guide 51.

  The light source filter 33 is inserted into or removed from the optical path by operating an operation input unit 53 provided in the electronic endoscope 50. Based on the input to the operation input unit 53, the system controller 21 controls the motor 35, and the light source filter 33 is inserted or removed.

  Note that the endoscope system 10 is provided with a reference light image display mode, an autofluorescence image display mode, and a pseudo color image display mode. In the reference light image display mode, the light source filter 33 leaves the optical path. In the autofluorescence image display mode, the light source filter 33 is inserted into the optical path. In the pseudo color image display mode, the insertion and removal of the light source filter 33 in the optical path are alternately repeated in synchronization with a continuous field.

  Next, the configuration of the electronic endoscope 50 will be described in detail. The electronic endoscope 50 is provided with a light guide 51, an imaging device 52, an operation input unit 53, an excitation light cut filter 54, and the like. The light guide 51 extends from the connection portion with the endoscope processor 20 to the distal end of the insertion tube 55 of the electronic endoscope 50.

  As described above, the reference light or excitation light emitted from the light source unit 30 enters the incident end of the light guide 51. The light incident on the incident end is transmitted to the exit end. Light exiting from the exit end of the light guide 51 is applied to the vicinity of the distal end of the insertion tube 55 via the light distribution lens 56.

  The image sensor 52 is driven by the image sensor driving circuit 23 so as to capture at least one field of subject image while the reference light is continuously irradiated or while the excitation light is continuously irradiated. . The operation of the image sensor driving circuit 23 is controlled by the timing controller 22.

  An optical image by reflected light of the subject when irradiated with the reference light and an optical image by fluorescence of the subject when irradiated with the excitation light are formed on the light receiving surface of the image sensor 52 by the objective lens 57.

  During excitation light irradiation, the excitation light component reflected by the subject is removed from the light incident through the objective lens 57 by the excitation light cut filter 54. By removing the excitation light component, only the fluorescent component emitted from the living tissue as the subject is imaged by the imaging element 52.

  By executing the imaging operation, the imaging device 52 generates an image signal. Therefore, when the reference light is irradiated, a reference light image signal corresponding to the optical image by the reflected light of the subject is generated. Further, when the excitation light is irradiated, a fluorescence image signal corresponding to an optical image by fluorescence of the living tissue is generated. The reference light image signal and the fluorescence image signal are sent to the image processing unit 40.

  A plurality of pixels (not shown) are provided on the light receiving surface of the image sensor 52. By executing the imaging operation of the imaging element 52, a pixel signal corresponding to the amount of received light in each pixel is generated. The image signal is composed of pixel signals generated in the plurality of pixels.

  Each pixel is covered with a color filter of any one of an R filter, a G filter, and a B filter (not shown). Each color filter is arranged according to the Bayer method.

  A pixel signal generated in a pixel covered with each color filter is a pixel signal corresponding to the amount of light received by a light component transmitted by each color filter. That is, the R signal component corresponding to the received light amount of the red light component from the pixel covered by the R filter, and the G signal component corresponding to the received light amount of the green light component from the pixel covered by the G filter are converted to the B filter. A B signal component corresponding to the amount of received blue light component is generated from the pixel covered by the pixel and sent to the image processing unit 40.

  Next, the configuration of the image processing unit 40 will be described. The image processing unit 40 includes a front-stage signal processing circuit 41, an image processing unit 42, a DRAM 43, a rear-stage signal processing circuit 44, and the like.

  The image signal composed of the R signal component, the G signal component, and the B signal component is sent to the pre-stage signal processing circuit 41. In the pre-stage signal processing circuit 41, the image signal is converted from an analog signal to a digital signal.

  Further, the pre-stage signal processing circuit 41 performs predetermined signal processing such as color interpolation processing and white balance. The pixel signal corresponding to each pixel is one of an R signal component, a G signal component, and a B signal component, but an R signal component, a G signal component, and a B signal component corresponding to each pixel are generated by color interpolation processing. Is done.

  The image signal subjected to the predetermined signal processing is sent to the image processing unit 42. The image signal sent to the image processing unit 42 is sent to the DRAM 43 and stored therein. In the reference light image display mode or the autofluorescence image display mode, the image signal stored in the DRAM 43 is sent to the subsequent signal processing circuit 44 via the image processing unit 42. On the other hand, in the pseudo color image display mode, pseudo color image processing for creating a pseudo color image is performed on the image signal stored in the DRAM 43 as described later. The image signal subjected to the pseudo color image processing is sent to the subsequent signal processing circuit 44.

  The image signal sent to the post-stage signal processing circuit 44 is subjected to predetermined signal processing such as clamping and blanking processing, and these image signals are converted from digital signals to analog signals. The image signal converted into the analog signal is sent to the monitor 60. An image corresponding to the sent image signal is displayed on the monitor 60.

  Next, the configuration of the image processing unit 42 and the pseudo color image processing performed by the image processing unit 42 in the pseudo color image display mode will be described with reference to FIG. FIG. 2 is a block diagram showing an internal configuration of the image processing unit 42.

  The image processing unit 42 includes a matrix circuit 45, a ratio calculation circuit 46, a determination circuit 47, a pseudo color image calculation circuit 48, and a ROM 49.

  The image signal sent to the image processing unit 42 is input to the matrix circuit 45. In the matrix circuit 45, the image signal is decomposed into an R signal component, a G signal component, and a B signal component. The decomposed R signal component, G signal component, and B signal component are sent to the DRAM 43 and stored therein. In the pseudo color image display mode, when the decomposed image signal is a reference light image signal, the R signal component, the G signal component, and the B signal are also sent to the ratio calculation unit 46.

  The DRAM 43 is provided with a reference light image storage area and a fluorescence image storage area, and the reference light R signal component, the reference light G signal component, and the reference light B signal component obtained by decomposing the reference light image signal are stored in the reference light image. The fluorescence R signal component, the fluorescence G signal component, and the fluorescence B signal component which are stored in the region and decomposed the fluorescence image signal are stored in the fluorescence image storage region.

  In the ratio calculation circuit 46, the reference light G signal component and the reference light B signal component of the same pixel are divided by the reference light R signal component, and G / R and B / R are calculated. The calculated G / R and B / R are sent to the discrimination circuit 47.

  In the determination circuit 47, it is determined whether or not the optical image received by each pixel is a bleeding estimation region based on G / R and B / R. Note that the bleeding estimation region is a region that is considered to have captured the bleeding site of the subject in the entire imaging region in which the subject image was captured.

  As shown in FIG. 3, on the graph having G / R as the horizontal axis and B / R as the vertical axis, the first range where g1 <G / R <g2 is satisfied, and the first range where b1 <B / R <b2 is satisfied. An area surrounded by the range 2 is defined as a bleeding determination area.

  In the pixel signal corresponding to the optical image of the bleeding site, the signal intensity of the G signal component and the B signal component with respect to the R signal component is relatively low. Therefore, it is observed that G / R and B / R at the bleeding site are included in a predetermined range lower than 1. As described above, the values of g1, g2, b1, and b2 are determined based on the measurement result and stored in the ROM 49.

  It is confirmed whether G / R and B / R of each pixel are included in the first and second ranges, respectively. A pixel when G / R is included in the first range and B / R is included in the second range is determined to be a pixel in the bleeding estimation region. Other pixels, that is, pixels in which at least one of G / R and B / R is outside the first and second ranges are determined to be non-bleeding region pixels.

  The result of determining that the pixel is a bleeding estimation region pixel or a non-bleeding region pixel is sent to the pseudo color image calculation circuit 48 as a determination signal. Further, an image signal is sent from the DRAM 43 to the pseudo color image calculation circuit 48. From the DRAM 43, a reference light R signal component, a reference light G signal component, and a reference light B signal component, and a fluorescence R signal component, a fluorescence G signal component, and a fluorescence B signal component are sent.

  When the determination circuit 47 determines that the pixel is in the bleeding estimation region, the fluorescence R signal component, the fluorescence G signal component, and the fluorescence B signal component are discarded. On the other hand, the reference light R signal component, the reference light G signal component, and the reference light B signal component are sent to the subsequent signal processing circuit 44. That is, when it is determined that the pixel is in the bleeding estimation region, the pixel signal forming the reference light image signal is sent to the subsequent signal processing circuit 44.

  When the determination circuit 47 determines that the pixel is a non-bleeding region pixel, the reference light R signal component, the reference light G signal component, and the reference light B signal component, the fluorescence R signal component, the fluorescence G signal component, and the fluorescence B A pseudo color image (lesion site estimation image) is created based on the signal component.

  The pseudo color image is an area that is darkly displayed in the fluorescent image that is an image corresponding to the fluorescent image signal, and only a region that is brightly displayed in the reference light image corresponding to the reference light image signal is a predetermined color. It is an image colored with.

  The pseudo color image is created by performing the following processing, for example. First, the luminance of pixel signals of all pixels in the non-bleeding region, which are pixel signals forming one field of reference light image signal, is calculated. Further, an average value of the obtained luminance is calculated.

  Similarly, it is a pixel signal that forms a fluorescence image signal of one field, and the luminance of the pixel signal of all the pixels in the non-bleeding region and the average value of the luminance are calculated. Normalization of the pixel signal forming the fluorescent image signal is performed so that the average values of the two coincide.

  The luminance ratio is calculated by dividing the normalized luminance signal component of the pixel signal by the luminance signal component of the pixel signal forming the reference light image signal. The luminance ratio is compared with a predetermined threshold, and a pixel signal colored with a pseudo color such as blue is generated for a pixel having a luminance ratio smaller than the predetermined threshold, and is sent to the subsequent signal processing circuit 44. On the other hand, a pixel signal forming a reference light image signal is sent to the subsequent signal processing circuit 44 for a pixel having a luminance ratio larger than a predetermined threshold.

  An image signal of one frame is sent to the post-stage signal processing circuit 44 by the pixel signal of the pixel in the bleeding estimation region and the pixel signal of the pixel in the non-bleeding region. As described above, the image signal formed by the pixel signal of the pixel in the bleeding estimation region and the pixel signal of the pixel in the non-bleeding region corresponds to the reference light image colored only by the pseudo color only in the region estimated as the lesioned part. .

  When a subject having a lesion part DP, a healthy part around the lesion part, and a bleeding part BP as shown in FIG. 4 is photographed, a pseudo color image is not created in the bleeding estimation area BA (see FIG. 5). A light image is created. On the other hand, a pseudo color image is created in the lesioned region BP and the imaging region of the healthy part (see the non-bleeding region NBA in FIG. 5). As a result, as shown in FIG. 6, only the lesion site DP is colored with a pseudo color, and an entire image that is a normal reference light image is created in other regions.

  Next, pseudo color image processing performed in the image processing unit 40 when the pseudo color display mode is set will be described with reference to the flowchart of FIG.

  By switching to the pseudo color image display mode, the pseudo color image processing in the present embodiment is started. First, in step S100, an image signal generated by the electronic endoscope 50 is received. In the next step S101, predetermined signal processing in the preceding signal processing circuit 41 is performed on the image signal.

  When predetermined signal processing is performed, the process proceeds to step S102, where the image signal is decomposed into an R signal component, a G signal component, and a B signal component. When the signal is decomposed into the R signal component, the G signal component, and the B signal component, the process proceeds to step S103.

  In step S103, G / R and B / R for each pixel are calculated. In the next step S104, it is determined whether or not G / R and B / R are within the range of the bleeding determination region (see FIG. 3). That is, it is determined whether or not g1 <G / R <g2 and b1 <B / R <b2.

  If G / R and B / R are outside the range of the bleeding determination area in step S104, the process proceeds to step S105. In step S105, a pseudo color image is created at pixels whose G / R and B / R are outside the range of the bleeding determination region.

  When G / R and B / R are within the range of the bleeding determination area in step S104, the process proceeds to step S106. In step S106, a reference light image is created in pixels where G / R and B / R are within the range of the bleeding determination region.

  After the processing of step S105 or step S106 is completed for all pixels, the pseudo color image processing performed by the image processing unit 40 is completed.

  As described above, according to the endoscope processor 20 of the present embodiment, a pseudo color image is not created for the bleeding estimation region, and a pseudo color image is created only for the non-bleeding region. It becomes possible to clearly indicate the estimated region.

  In the present embodiment, the pixel in the bleeding estimation region is configured to generate the reference light image signal, but may be configured to be colored with a color different from the pseudo color. Alternatively, the pixels in the bleeding estimation region may be covered with a predetermined form of shading.

  Note that when the pixels in the bleeding estimation region are colored or shaded as described above, a pseudo color image may be once created for the entire imaging region. If coloring or shading is performed after the entire pseudo color image is created, an image that is not related to the fluorescence image signal is displayed in the bleeding estimation region, so that the same effect as in this embodiment can be obtained. .

  In this embodiment, the pseudo color image in the non-bleeding region is created. However, any image that can estimate the lesion site may be created. For example, even if the autofluorescence image itself is displayed, it is possible to identify the lesion site in distinction from the bleeding site. However, in an autofluorescence image, it is difficult to distinguish between a luminal site and a lesion site, and therefore it is preferable to create an image that displays a lesion site in a distinguishable manner from other sites as in this embodiment.

  In this embodiment, an example pseudo color image is created as an image that can estimate a lesion site. However, a pseudo color image is created that colors pixels that are displayed brightly in the reference light image and darkly displayed in the fluorescence image. For example, a pseudo color image created by another method may be used. Furthermore, the region estimated to be a lesion site may not be colored with a pseudo color. For example, a configuration in which a boundary between a lesion site and a healthy site is clearly indicated may be used.

  In the present embodiment, the configuration is such that the bleeding estimation region and the non-bleeding region are discriminated depending on whether G / R and B / R are included in the first and second ranges, but by any other method. Even if it discriminate | determines, it is possible to acquire the effect similar to this embodiment.

  In the present embodiment, it is configured to determine whether the pixel is a bleeding estimation region or a non-bleeding region for all pixels, but the luminance signal component of the pixel signal forming the fluorescent image signal is below the threshold value. It is only necessary to determine whether or not the pixel is a bleeding estimation region. Thus, according to the configuration for determining whether or not a part of the pixels is a bleeding estimation region, it is possible to reduce the amount of calculation for determining whether or not it is a bleeding estimation region. .

  In addition, the endoscope processor 20 to which this embodiment is applied reads the pseudo color image creation program into a general-purpose endoscope processor incorporating a light source unit or a general-purpose endoscope processor connectable to an external light source unit. It is also possible to configure.

1 is a block diagram schematically showing an internal configuration of an endoscope system having an endoscope processor to which an embodiment of the present invention is applied. FIG. It is a block diagram which shows roughly the internal structure of an image process part. It is a graph which shows a bleeding discrimination area. An image of a living tissue including a bleeding site and a lesion site is shown. FIG. 5 is a diagram for explaining a region in which a reference light image is created and a region in which a pseudo color image is created in the biological tissue image of FIG. 4. An image created by performing pseudo color image processing is shown. It is a flowchart for demonstrating the pseudo color image processing performed by an image processing unit.

Explanation of symbols

DESCRIPTION OF SYMBOLS 10 Endoscope system 20 Endoscope processor 21 System controller 22 Timing controller 23 Image pick-up element drive circuit 30 Light source unit 31 Light source 32 Condensing lens 33 Light source filter 34 Light source filter drive mechanism 35 Motor 36 Position detection sensor 40 Image processing unit 41 Previous stage Signal processing circuit 42 Image processing unit 43 DRAM
44 Subsequent signal processing circuit 45 Matrix circuit 46 Ratio calculation circuit 47 Discrimination circuit 48 Pseudo color image arithmetic circuit 49 ROM
DESCRIPTION OF SYMBOLS 50 Electronic endoscope 51 Light guide 52 Image pick-up element 53 Operation input part 54 Excitation light cut filter 55 Insertion tube 56 Light distribution lens 57 Objective lens 60 Monitor BA Bleeding estimation area BP Bleeding part DP Lesion part NBA Non-bleeding area

Claims (8)

Generated when the reference light is irradiated from an imaging device that generates respective image signals based on optical images of respective subjects irradiated with excitation light or reference light that emits fluorescence when irradiated on a living tissue at different timings A receiving unit that receives a reference light image signal that is the image signal and a fluorescent image signal that is the image signal generated when the excitation light is irradiated;
Based on the color signal component that forms the reference light image signal, a color discrimination unit that identifies a bleeding estimation region estimated as a bleeding site inside an imaging region that is a region photographed by the imaging device;
An endoscope processor comprising: an image processing unit that creates a lesion estimated image based on the fluorescence image signal only in a non-bleeding region that is the imaging region other than the bleeding estimation region. The color signal is an R signal component, a G signal component, and a B signal component,
The color discriminating unit calculates G / R and B / R, which are ratios of the signal intensity of the G signal component and the B signal component with respect to the R signal component, and G / R is within the first range, The endoscope processor according to claim 1, wherein a region where R is in a second range is specified as the bleeding estimation region.   The specification of the bleeding estimation region by the color discrimination unit is performed on a region whose luminance is lower than a threshold in a fluorescent image corresponding to the fluorescent image signal. Endoscopic processor.   The endoscope processor according to any one of claims 1 to 3, wherein the lesion site estimation image is created based on the reference light image signal.   The endoscope processor according to any one of claims 1 to 4, wherein the image processing unit colors the bleeding estimation region in a predetermined color.   The endoscope processor according to any one of claims 1 to 4, wherein the image processing unit shades the bleeding estimation region in a predetermined form. Generated when the reference light is irradiated from an imaging device that generates respective image signals based on optical images of respective subjects irradiated with excitation light or reference light that emits fluorescence when irradiated on a living tissue at different timings A driving unit that causes a receiving unit to receive a reference light image signal that is the image signal and a fluorescent image signal that is the image signal generated when the excitation light is irradiated;
A color discriminating unit that identifies a bleeding estimation region estimated as a bleeding site in an imaging region, which is a region imaged by the imaging device, based on a color signal forming the reference light image signal;
An auto-fluorescent image display characterized by causing an endoscope processor to function as an image processing unit that creates a lesion estimated image based on the fluorescence image signal only in a non-bleeding region that is the imaging region other than the bleeding estimation region. program. A light source unit that emits excitation light that emits fluorescence when irradiated with reference light and biological tissue;
A light source controller that emits the excitation light and the reference light at different timings;
A fluorescent image signal is generated by receiving an optical image of the subject when the excitation light is applied to the subject, and a reference light image is received by receiving the optical image of the subject when the reference light is applied to the subject. An image sensor for generating a signal;
A color discriminating unit that identifies a bleeding estimation region estimated as a bleeding site in an imaging region, which is a region imaged by the imaging device, based on a color signal forming the reference light image signal;
An image processing unit that creates a lesion estimated image based on the fluorescence image signal only in a non-bleeding region that is the imaging region other than the bleeding estimation region;
An endoscope system comprising: a monitor that displays the lesion-containing image created in the image processing unit.

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