JP2008058250A - Analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an analyzer for preventing a reaction liquid and a cleaning liquid overflowing from a reaction vessel, from being diffused. <P>SOLUTION: The analyzer of the present invention for measuring an optical characteristic of the reaction liquid within the reaction vessel 7 accommodated in a rotating table 6 and for analyzing the reaction liquid is provided with: a cleaning apparatus 11 for injecting and sucking the cleaning liquid into/from the reaction vessel 7 after the measurement of the optical characteristic is completed, and for cleaning the reaction vessel; an opening 21b disposed, corresponding to an opening in the reaction vessel 7 accommodated in the rotating table 6; a flow path for guiding the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 toward an exterior of an outer wall of the reaction vessel through the opening 21b; a lid 21 for closely contacting an upper face of a side wall of the reaction vessel for composing the opening of the reaction vessel 7; a discharge groove 22 for discharging the reaction liquid and cleaning liquid guided by the flow path in the lid 21 to an exterior of the lid. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  The present invention relates to an analyzer for analyzing a reaction solution by measuring optical characteristics of the reaction solution contained in a reaction vessel.

  Conventionally, in an analyzer that analyzes the reaction liquid by measuring the optical characteristics of the reaction liquid including human blood and urine, the reaction between the reagent held in the reaction container and the sample is performed at a predetermined temperature. There is provided a thermostatic chamber for keeping the temperature of the reaction solution in each reaction vessel accommodated in the rotary table. As this thermostat, a heat conduction tank enclosing a thermostatic liquid of a predetermined temperature or a heat conduction layer provided with a heater is provided around each reaction container accommodated in the rotary table to keep the reaction liquid in the reaction container warm. Has been proposed (see, for example, Patent Document 1). Further, a water bath type thermostatic bath has been proposed in which a constant temperature liquid at a predetermined temperature is accommodated and circulated, and the reaction container is directly immersed in the constant temperature liquid to keep the reaction liquid in the reaction container warm (for example, Patent Documents). 2).

JP-A 63-186129 JP-A-4-258767

  By the way, such an analyzer cleans the reaction container after the analysis and repeatedly uses the reaction container. Specifically, the analyzer sucks and discharges the reaction liquid in the reaction container whose measurement has been completed by the nozzle, and injects and sucks and discharges the cleaning liquid such as detergent and washing water. Cleaning is performed.

  However, in the past, if the suction nozzle was clogged during cleaning, the reaction liquid or cleaning liquid could not be sucked and overflowed from the reaction container, and the overflowing reaction liquid or cleaning liquid was stored in the rotary table containing the reaction container or on the rotating table. I got around the table. In this case, in the dry bath type thermostatic bath, there is a problem that the reaction liquid and the cleaning liquid overflowing from the reaction container enter the periphery of the reaction container, and the reaction container surface is clouded to make photometry impossible. Also, in the water bath type thermostatic chamber, the reaction liquid and cleaning liquid overflowing from the reaction vessel are mixed into the thermostatic liquid in the thermostatic bath, the thermostatic liquid in the thermostatic bath is contaminated, and the photometric accuracy is reduced. There was a problem.

  The present invention has been made in view of the above, and an object of the present invention is to provide an analyzer that prevents diffusion of a reaction solution and a washing solution overflowing from a reaction vessel.

  In order to solve the above-mentioned problems and achieve the object, an analyzer according to the present invention is an analyzer for analyzing the reaction liquid by measuring optical characteristics of the reaction liquid in the reaction vessel stored in the storage means. The cleaning device is provided corresponding to an opening portion of the reaction container accommodated in the storage means, and a cleaning means for injecting and sucking a cleaning liquid into the reaction container for which the measurement of the optical characteristics is completed and sucking the reaction container. An open area, and a flow path for guiding the reaction liquid and the washing liquid overflowing from the reaction container through the open area toward the outside of the outer wall of the reaction container, A lid closely contacting the upper surface of the side wall of the reaction container; and a discharge means for discharging the reaction liquid and the cleaning liquid guided by the flow path in the lid to the outside of the lid.

  In the analyzer according to the present invention, the lid is provided with a partition between the open regions to form the flow path.

  Further, the analyzer according to the present invention is characterized in that the lid is provided with a downward slope in a region located on the discharge means side to form the flow path.

  In the analyzer according to the present invention, the lid includes an elastic body that seals between the upper surface of the side wall of the reaction vessel and the lower surface of the lid constituting the opening of the reaction vessel.

  Moreover, the analyzer according to the present invention is characterized in that the lid is provided with a recess for storing the reaction liquid and the washing liquid overflowing from the reaction container to form the flow path.

  In the analyzer according to the present invention, the discharge means is provided outside the storage means, and discharges the reaction liquid and the cleaning liquid guided by the flow path of the lid to the outside of the lid. And the flow path in the lid guides the reaction liquid and the cleaning liquid overflowing from the reaction container to the discharge means.

  Further, in the analyzer according to the present invention, the discharge means is a suction device that sucks the reaction liquid and the cleaning liquid accumulated in the recess and discharges the sucked reaction liquid and the cleaning liquid to the outside of the lid. It is characterized by that.

  Further, the analyzer according to the present invention is configured to detect whether or not the reaction liquid and the cleaning liquid have accumulated in the recess, and the detection means detects that the reaction liquid and the cleaning liquid have accumulated in the recess. And an output means for outputting a warning indicating that the reaction liquid and the cleaning liquid have overflowed from the reaction container.

  In the analyzer according to the present invention, when the detection unit detects that the reaction liquid and the cleaning liquid are accumulated in the concave portion, the suction device removes the reaction liquid and the cleaning liquid accumulated in the concave portion. It sucks and discharges outside the lid.

  Further, in the analyzer according to the present invention, the storage means is configured by a plurality of storage units that store a predetermined number of reaction containers and are detachable from the analyzer, and the lid corresponds to the storage unit. It is characterized by comprising a plurality of lid units having a size.

  The analyzer according to the present invention includes a lid having a flow path for guiding the reaction liquid and the washing liquid overflowing from the reaction container toward the outside of the outer wall of the reaction container, and the reaction liquid and the washing liquid guided by the flow path in the lid. By providing the discharge means for discharging to the outside, it becomes possible to prevent the diffusion of the reaction liquid and the cleaning liquid overflowing from the reaction vessel.

  Hereinafter, an analyzer according to an embodiment of the present invention will be described with reference to the drawings. Note that the present invention is not limited to the embodiments. In the description of the drawings, the same parts are denoted by the same reference numerals.

(Embodiment 1)
First, the first embodiment will be described. FIG. 1 is a schematic configuration diagram of an analyzer according to the first embodiment. As shown in FIG. 1, the analyzer 1 according to the first embodiment includes a sample table 3, a sample dispensing mechanism 5, a rotating table 6, a photometric device 10, a cleaning device 11, and a reagent dispensing mechanism 12 on a work table 2. A reagent table 13, a stirring device 20, an inner lid 21 and a drain groove 22 are provided. The sample to be analyzed and the reagent used for the analysis of the sample are accommodated in the reaction container 7 (see FIG. 2).

  As shown in FIG. 1, the sample table 3 is rotated in the direction indicated by the arrow by the driving means, and a plurality of storage chambers 3 a are provided on the outer periphery at regular intervals along the circumferential direction. In each storage chamber 3a, a sample container 4 storing a sample is detachably stored.

  The sample dispensing mechanism 5 is means for dispensing a sample into a plurality of reaction containers 7 held on a rotary table 6, and sequentially reacts the samples from the plurality of sample containers 4 on the sample table 3 as shown in FIG. Dispense into container 7.

  The rotary table 6 is rotated in a direction indicated by an arrow in FIG. 1 by a driving means different from that of the sample table 3, and a plurality of holders for individually storing reaction containers 7 holding liquids including reagents and samples on the outer periphery. Are provided on the top plate 6b at equal intervals along the circumferential direction. A plurality of holders 6a (see FIGS. 3 and 4) are detachably provided on the top plate 6b at equal intervals along the circumferential direction. The holder 6a is held by the top plate 6b in a state of being connected by a suitable connecting plate 6f, but may be held by the top plate 6b individually. Further, an elastic body 6e is fixed to a part of the inner wall of the holder 6a, and the accommodated reaction vessel 7 is held so as not to be easily detached from the holder 6a. The reaction vessel 7 can be taken out from the holder by an operation such as pulling it up from the holder 6a with fingers or protruding upward from a through hole (not shown) provided on the bottom surface of the holder 6a with an appropriate rod member. Yes. The turntable 6 rotates clockwise (1 turn-1 reaction vessel) / 4 minutes in one cycle, and rotates one holder in the counterclockwise direction in four cycles. In the vicinity of the outer periphery of the turntable 6, a photometric device 10, a cleaning device 11, and a stirring device 20 are arranged. An openable / closable outer lid (not shown) is provided above the rotary table 6. Further, below the rotary table 6, a constant temperature bath described later is provided in the circumferential direction via a holder 6a and a predetermined gap. For this reason, when the reaction container 7 is accommodated in the turntable 6 and the outer lid is closed, the reaction solution accommodated in the reaction container 7 can be kept in a constant temperature state.

  An inner lid 21 is provided on the rotary table 6 in addition to the outer lid. The inner lid 21 is provided in the circumferential direction from the upper part of the reaction container 7 housed in the turntable 6 to the end of the turntable 6 so as to cover at least the reaction container 7. The lower surface of the inner lid 21 is in close contact with the upper surface of the side wall constituting the opening of the reaction vessel 7. The inner lid 21 is provided with an opening 21b provided corresponding to the opening of each reaction vessel 7 housed in the turntable 6, and the reaction solution and the cleaning solution overflowing from the reaction vessel 7 through the opening 21b. It has a flow path that leads outside the outer wall of the reaction vessel 7. The reaction container 7 for storing the specimen and reagent is stored in the turntable 6 below the opening 21b.

  A drainage groove 22 is provided on the outer side of the turntable 6 in the circumferential direction. The drainage groove 22 discharges the reaction liquid and the cleaning liquid guided by the flow path in the inner lid 21 to the outside of the inner lid 21. The inner lid 21 and the drainage groove 22 prevent the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 from entering the rotary table 6 and the periphery of the rotary table.

  As shown in FIG. 1, the photometric device 10 is disposed near the outer periphery of the rotary table 6, and transmits a light source that emits analysis light (340 to 800 nm) for analyzing the liquid held in the reaction vessel 7 and transmits the liquid. And a light receiver that splits and receives the analysis light. In the photometric device 10, the light source and the light receiver are arranged at positions facing each other in the radial direction with the holder of the rotary table 6 interposed therebetween.

  The cleaning device 11 sucks and discharges the reaction liquid in the reaction vessel 7 that has been measured by the photometric device 10 by the nozzles 11a and 11b (see FIG. 2), and injects and sucks cleaning liquid such as detergent and cleaning water. As a result, the reaction vessel 7 is washed. The cleaning apparatus 11 dispenses the cleaning solution after discharging the photometric reaction solution from the reaction vessel 7 after photometry. And the washing | cleaning apparatus 11 wash | cleans the inside of the reaction container 7 by repeating operation | movement of dispensing and discharge | emission of washing | cleaning liquid in multiple times. The reaction container 7 washed in this way is used again for analysis of a new specimen.

  The reagent dispensing mechanism 12 is a means for dispensing a reagent to a plurality of reaction containers 7 held on the rotary table 6, and sequentially reacts the reagents from a predetermined reagent container 14 of the reagent table 13 as shown in FIG. Dispense into container 7.

  The reagent table 13 is rotated in a direction indicated by an arrow in FIG. 1 by a driving means different from the sample table 3 and the rotary table 6, and a plurality of storage chambers 13a formed in a fan shape are provided along the circumferential direction. In each storage chamber 13a, the reagent container 14 is detachably stored. Each of the plurality of reagent containers 14 is filled with a predetermined reagent corresponding to the inspection item, and an information medium (not shown) for recording information about the stored reagent is attached to the outer surface.

  On the outer periphery of the reagent table 13, as shown in FIG. 1, a reading device 15 that reads information such as the reagent type, lot, and expiration date recorded on the information medium attached to the reagent container 14 and outputs the information to the control unit 16. Is installed.

  The control unit 16 includes a sample table 3, a sample dispensing mechanism 5, a rotary table 6, a photometric device 10, a cleaning device 11, a reagent dispensing mechanism 12, a reagent table 13, a reading device 15, an analysis unit 17, an input unit 18, and a display. For example, a microcomputer or the like that is connected to the unit 19 and the stirring device 20 and has a storage function for storing the analysis result is used. The control unit 16 controls the operation of each unit of the analysis apparatus 1 and performs analysis so as to stop the analysis work when the reagent lot or expiration date is out of the installation range based on the information read from the record of the information medium. A function of controlling the device 1 or issuing a warning to the operator is provided.

  The analysis unit 17 is connected to the photometric device 10 via the control unit 16, analyzes the component concentration of the specimen from the absorbance of the liquid in the reaction container 7 based on the light quantity received by the light receiver, and analyzes the analysis result to the control unit 16. Output to. The input unit 18 is a part that performs an operation of inputting inspection items and the like to the control unit 16, and for example, a keyboard, a mouse, or the like is used. The display unit 19 displays analysis contents, analysis results, warnings, or the like, and a display panel or the like is used. The stirring device 20 is a device that stirs the liquid held in the reaction vessel 7, and includes a device that stirs the liquid directly with a stirring rod and a device that stirs the liquid in a non-contact manner using sound waves.

  In the analyzer 1 configured as described above, the reagent dispensing mechanism 12 sequentially dispenses the reagents from the reagent container 14 to the plurality of reaction containers 7 conveyed along the circumferential direction by the rotating rotary table 6. The reaction container 7 into which the reagent has been dispensed is conveyed along the circumferential direction by the rotary table 6, and the specimen is sequentially dispensed from the plurality of specimen containers 4 held on the specimen table 3 by the specimen dispensing mechanism 5.

  Then, the reaction container 7 into which the sample has been dispensed is conveyed to the stirring device 20 by the rotary table 6, and the dispensed reagent and the sample are sequentially stirred and reacted. The reaction container 7 holding the reaction liquid in which the sample and the reagent have reacted in this way passes through the photometric device 10 when the rotary table 6 rotates again, and transmits the luminous flux of the analysis light emitted from the light source. At this time, the light beam that has passed through the reaction solution is measured by the light receiving unit, and the component concentration and the like are analyzed by the analyzing unit 17. After the analysis is completed, the reaction vessel 7 is washed by the washing device 11 and then used again for analyzing the specimen. The analyzer 1 automatically executes such a series of operations under the control of the control unit 16.

  Next, the rotary table 6, the inner lid 21, and the drainage groove 22 shown in FIG. 1 will be described with reference to FIGS. 2 to 5. FIG. 2 is an enlarged plan view of the rotary table, cleaning device, inner lid, and drainage groove of the analyzer shown in FIG. FIG. 3 is an enlarged perspective view showing a part of the rotary table and the inner lid shown in FIGS. 1 and 2. 4 is a cross-sectional view taken along line X1-X1 shown in FIG. FIG. 5 is an enlarged plan view showing a part of the inner lid and the drainage groove shown in FIG.

  As shown in FIGS. 2, 3, and 5, the inner lid 21 provided on the turntable 6 is provided with a partition 21 a between the openings 21 b of the inner lid 21. As shown in FIGS. 2 and 4, the reaction liquid and the cleaning liquid that have flowed into the drainage groove 22 are supplied to the drainage groove 22 provided below and on the outer periphery of the turntable 6 through a tube 22 b to be connected to the outside. A drain port 22a for discharging is provided. As shown in FIGS. 2 and 4, the cleaning device 11 includes a nozzle 11 a that sucks the liquid in the reaction container 7 and a nozzle 11 b that injects the cleaning liquid 11 c into the reaction container 7.

  As shown in FIGS. 3 and 4, the inner lid 21 is attached to the top plate 6 b by screws 21 e inserted through the screw holes 21 d so that the opening 21 b overlaps the opening portions of the top plate 6 b and the reaction vessel 7. The screw hole 6d is fastened to the top plate 6b. For this reason, the inner lid 21 rotates integrally with the top plate 6b. Further, as shown in FIG. 4, the inner lid 21 is fixed to the top plate 6 b so that the opening 21 b overlaps the opening portions of the top plate 6 b and the reaction vessel 7. For this reason, the nozzle in the specimen dispensing mechanism 5, the nozzle in the reagent dispensing mechanism 12, and the nozzles 11a and 11b in the cleaning device 11 are passed through the opening 21b and the opening of the top plate 6b that overlap the opening in the reaction vessel 7. Can be inserted into and removed from the reaction vessel 7. Therefore, the specimen dispensing mechanism 5, the reagent dispensing mechanism 12, and the cleaning device 11 can inject the specimen, reagent, and cleaning liquid into the reaction container 7.

  As shown in FIGS. 3 and 4, in the inner lid 21, the partition 21 a that partitions the openings 21 b and a wall that is in contact with the end on the center side of the top plate 6 b of each partition 21 a in the region Sh. Are provided in the circumferential direction. The height of the partition 21a and the wall of the region Sh is set so that the reaction liquid and the washing liquid overflowing from the reaction container 7 do not enter the adjacent reaction container 7 and are contained in the reaction container 7 and the reaction container 7 It is set based on the volume of cleaning liquid injected into the. Further, as shown in FIGS. 3 to 5, in the inner lid 21, a downward slope is provided in an outer peripheral region Sp located on the drainage groove 22 side.

  Further, as shown in FIG. 4, the analyzer 1 is provided with a constant temperature bath 6c surrounding the reaction vessel 7 in a circumferential direction through a predetermined gap S from the side wall to the bottom wall of the reaction vessel 7 below the top plate 6b. It has been. The constant temperature bath 6c is composed of an outer wall 6c1 and an inner wall 6c2 made of a member having high thermal conductivity and a constant temperature liquid 6c3 stored therein, and conducts heat from a heater (not shown) to the reaction vessel 7 so as to react with the reaction vessel 7. The reaction solution inside is kept at a predetermined temperature.

  Here, in the analyzer 1, the case where the suction nozzle 11b is clogged at the time of cleaning and the reaction solution and the cleaning solution cannot be sucked and the reaction solution and the cleaning solution overflow from the reaction vessel 7 will be referred to FIG. 4 and FIG. To explain. 4 and 5, the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 overflow on the inner lid 21 through the opening 21b. The reaction liquid and the cleaning liquid overflowing from the opening 21b flow to the outer peripheral side of the inner lid 21 instead of the inner peripheral side of the inner lid 21 as shown by an arrow Ya by being blocked by the wall of the region Sh. Further, since the inner lid 21 is provided with a partition 21a between the openings 21b, as shown by an arrow Yd shown in FIG. 5, the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7a shown in FIG. It is not blocked by 21a and does not enter the adjacent reaction vessel 7b. Then, the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7a flow down into the drainage groove 22 from the outer peripheral side of the inner lid 21 due to the inclination of the region Sp as shown by the arrow Yb, and the drainage as shown by the arrow Yc. The water is discharged from the drain 22a in the groove 22 to the outside through the tube 22b.

  Thus, in the inner lid 21, the partition 21 a, the region Sh provided with the wall, and the region Sp provided with the inclination allow the reaction solution and the washing solution overflowing from the reaction vessel 7 to flow outside the outer wall of the reaction vessel 7. A flow path is formed to guide it toward. Then, the reaction liquid and the cleaning liquid guided by the flow path in the inner lid 21 are output to the outside through the discharge groove 22.

  Conventionally, when the reaction liquid or the cleaning liquid overflows from the reaction vessel, it has entered the rotary table or around the rotary table. Therefore, in the dry bath type thermostat as shown in FIG. 6, the reaction liquid and the cleaning liquid 11c overflowing from the reaction vessel 7 as shown by the arrow Yf enter the periphery of the reaction vessel 7 as shown by the arrow Yg. As a result, the cleaning liquid 11c adhered to the surface of the reaction vessel, and the cloudiness 7c was generated on the surface of the reaction vessel. In addition, in the water bath type thermostatic bath as shown in FIG. 7, as shown by the arrow Yh, the reaction liquid and the cleaning liquid 11c overflowing from the reaction vessel 7 are mixed into the thermostatic liquid 106c in the thermostatic bath, The constant temperature liquid 106c has been contaminated. As a result, the light emitted from the light source 10a in the photometric device 10 is not sufficiently incident on the reaction liquid L in the reaction vessel 7 due to the cloudy 7c or the contamination of the constant temperature liquid 106c, and the transmitted light P that has passed through the liquid L. The amount of light will also decrease. For this reason, in the conventional analyzer, the amount of light received through the reaction liquid L in the reaction vessel 7 cannot be accurately measured, and a highly accurate analysis cannot be performed.

  On the other hand, in the analyzer 1 according to the first embodiment, the inner lid 21 having the flow path formed by the partition 21a, the region Sh provided with the wall, and the region Sp provided with the inclination and the drainage groove 22 are provided. , The reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 are discharged to the outside through a predetermined path to prevent diffusion of the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7. For this reason, damage to the analyzer due to overflow of the reaction solution and the cleaning solution from the reaction vessel 7 can be minimized. Specifically, in the analyzer 1, the reaction liquid and the cleaning liquid overflowing from the reaction container 7 do not enter the inside of the rotary table and the periphery of the rotary table, so that the reaction container 7 is not clouded or contaminated with the constant temperature liquid. As a result, in the analyzer 1, the light passing through the reaction solution in the reaction vessel 7 in the photometric device 10 is prevented by preventing a decrease in the amount of light passing through the reaction solution due to clouding of the reaction vessel 7 or contamination of the constant temperature solution. Since the amount of received light can be measured accurately, it becomes possible to perform highly accurate analysis.

  In the first embodiment, the case where both the partition 21a and the slope in the region Sp are provided as the inner lid has been described. However, the present invention is not limited to this, and only the partition 21a may be provided. This is because the reaction liquid and the washing liquid overflowing from the reaction vessel 7 can flow out toward the discharge groove 22 without entering the adjacent reaction vessel 7 by the partition 21a. Moreover, although the case where the slope was provided in the region Sp on the outer periphery of the inner lid 21 has been described, of course, all regions located outside the region Sh where the wall of the inner lid 21 is provided are provided with a downward slope. The reaction liquid overflowing from the container 7 and the cleaning liquid may be smoothly guided to the drain groove 22.

(Embodiment 2)
Next, a second embodiment will be described. FIG. 8 is an enlarged plan view of the rotary table, the cleaning device, the inner lid, and the drainage groove of the analyzer according to the second embodiment. As shown in FIG. 8, the analyzer according to the second embodiment has an inner lid 221 instead of the inner lid 21 in the analyzer 1 shown in FIGS. 1 and 2. Note that the analyzer according to the second embodiment has the same configuration as the analyzer 1 shown in FIG.

  Next, the inner lid 221 shown in FIG. 8 will be described with reference to FIG. FIG. 9 is a cross-sectional view taken along line X2-X2 shown in FIG. As shown in FIG. 9, the inner lid 221 is formed between the upper surface of the side wall of the reaction vessel and the top plate constituting the opening of the reaction vessel 7, and the upper surface around the opening of the side wall upper surface of the holder 6 a and the lower surface of the lid 221. The elastic body 221f is hermetically sealed. FIG. 10 is a plan view of the elastic body shown in FIG. As shown in FIG. 10, the elastic body 221f has a rectangular opening corresponding to the shape of the opening of the reaction vessel 7, and includes a holder 6a for accommodating the reaction vessel 7 on the side wall and the top plate 6b. Between the two. The elastic body 221f is formed of an elastic resin or the like. The inner lid 221 is provided so that the opening in the top plate 6b and the reaction vessel 7 and the opening 21b overlap with each other, and the nozzle 11a in the cleaning device 11 passes through the opening 21b and the opening in the top plate 6b. 11b can be inserted into and removed from the reaction vessel 7.

  When the inner lid 221 is screwed to the top plate 6b with the screw 21e, the upper surface of the elastic body 221f and the lower surface around the opening 21b of the inner lid 221 are in close contact, and the lower surface of the elastic body 221f and the reaction vessel 7 The upper surface of the side wall is in close contact with the upper surface around the opening of the top plate 6b. For this reason, the elastic body 221f seals between the upper surface of the side wall of the reaction vessel 7 and the upper surface around the opening of the top plate 6b and the lower surface of the lid 221. Therefore, the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 are sealed between the side wall upper surface of the reaction vessel 7 and the inner lid 221 and between the reaction vessel 7 side wall and the holder 6a by sealing with the elastic body 221f. No intrusion. As a result, as shown by the arrows Ya and Yb shown in FIG. 9, the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 are separated from the partition 21a in the inner lid 221, the area Sh provided with walls, and the area provided with an inclination. It is possible to reliably flow into the discharge groove 22 from the flow path formed by Sp, and it is possible to reliably discharge to the outside as indicated by the arrow Yc.

  Thus, in the second embodiment, the elastic body 221f that seals between the upper surface of the side wall of the reaction vessel constituting the opening of the reaction vessel 7 and the upper surface around the opening of the top plate 6b and the lower surface of the inner lid 221 is provided. By providing the provided inner lid 221, the same effects as those of the first embodiment can be obtained, and the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 can be reliably discharged to the outside.

  In addition, the elastic body concerning Embodiment 2 is not restricted to the elastic body 221f shown in FIG. In order to prevent intrusion between the reaction vessel 7 and the inner lid 221 due to the reaction liquid and the washing liquid overflowing from the reaction vessel 7, the elastic body is provided with the upper surface of the side wall and the inner lid of the reaction vessel constituting the opening of the reaction vessel 7. It is sufficient if the space between the lower surface of 221 is sealed. For this reason, as shown in FIG. 11, it may be an annular elastic body 221 fa, and as shown in FIG. 12, the opening may be an elastic body 221 fb smaller than the opening of the reaction vessel 7.

(Embodiment 3)
Next, a third embodiment will be described. FIG. 13 is a schematic configuration diagram of an analyzer according to the third embodiment. As shown in FIG. 13, the analyzer 301 according to the third embodiment includes an inner lid 321 instead of the inner lid 21 shown in FIG. 1. Further, the analyzer 301 has a configuration further including a detection device 323, as compared with the analyzer 1 shown in FIG. Note that the control unit 16 also controls the detection device 323.

  Next, the inner lid 321 and the detection device 323 will be described with reference to FIGS. 14 is an enlarged plan view of the rotary table, the cleaning device, the inner lid, the drainage groove, and the detection device of the analyzer shown in FIG. 15 is a cross-sectional view taken along line X3-X3 shown in FIG. FIG. 15 also describes the detection device 323, the control unit 16, and the display unit 19 for the sake of explanation. 16 is a cross-sectional view taken along line X4-X4 shown in FIG.

  As shown in FIGS. 14 and 15, the inner lid 321 has a concave portion 321 g formed in the circumferential direction in the outer circumferential region Pg of the lid portion 321 c as compared with the inner lid 21 according to the first embodiment. The reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 through the opening 21b on the inner lid 321 flow not to the inner circumference side of the inner lid 321 but to the outer circumference side of the inner lid 321 by being blocked by the wall of the region Sh. . Then, the reaction liquid and the cleaning liquid overflowing from the reaction container 7 are guided into the recess 321g as shown by an arrow Yi in FIG. 15 without being blocked by the partition 21a and entering the adjacent reaction container 7.

  Furthermore, as shown in FIGS. 14 and 16, the inner lid 321 has a groove 321 h connected to a part of the recess 321 g and the outer end of the inner lid 321. As shown by the arrow Yj in FIG. 16, the reaction liquid and the cleaning liquid accumulated in the concave portion 321g of the outer peripheral region Pg flow into the groove 321h and flow down to the drain groove 22 as shown by the arrow Yk. Then, as shown by the arrow Yc, the reaction solution and the cleaning solution are discharged to the outside from the drain port 22a in the drain groove 22 through the tube 22b.

  As described above, in the inner lid 321, the recesses 321 g and the grooves 321 h provided in the outer peripheral region Pg together with the region Sh provided with the partition 21 a and the wall allow the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 to flow into the inner lid 321. The flow path leading to the drainage groove 22 located outside is formed.

  As shown in FIGS. 14 and 15, the detection device 323 includes electrodes 323a and 323b. One end of each of the electrodes 323a and 323b is disposed in the recess 321g, and the other end of each of the electrodes 323a and 323b is connected to the detection device 323. When the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 accumulate in the recess 321g, the electrode 323a and the electrode 323b are connected via the liquid accumulated in the recess 321g. When the electrode 323a is an input electrode and the electrode 323b is an output electrode, an electrical signal input from the detection device 323 to the electrode 323a is transmitted to the electrode 323b via the liquid, and then output from the electrode 323b to the detection device 323. Is done. Therefore, when the electrical signal input to the electrode 323a is output from the electrode 323b, the detection device 323 detects that the reaction liquid and the cleaning liquid have accumulated in the recess 321g and the reaction liquid and the cleaning liquid have overflowed from the reaction vessel 7. On the other hand, when the electrical signal input to the electrode 323a is not output from the electrode 323b, the detection device 323 detects that the reaction liquid and the cleaning liquid are not accumulated in the recess 321g and the reaction liquid and the cleaning liquid are not overflowing from the reaction vessel 7. . The detection device 323 outputs the detection result to the control unit 16.

  Next, a processing procedure in the case where the reaction solution and the cleaning solution overflow from the reaction vessel in the analyzer 301 will be described with reference to FIG. First, as shown in FIG. 17, the control unit 167 determines whether or not the detection device 323 has detected an overflow of the reaction liquid and the cleaning liquid from the reaction container 7 (step S <b> 2). The control unit 16 repeats the determination in step S <b> 2 until the detection device 323 detects the overflow of the reaction liquid and the cleaning liquid from the reaction container 7. And when it is judged that the detection apparatus 323 detected the overflow of the reaction liquid and the washing | cleaning liquid from the reaction container 7 (step S2: Yes), the reaction part and the washing | cleaning liquid overflowed from the reaction container with respect to the display part 19. A warning is displayed. Under the control of the control unit 16, the display unit 19 performs a warning process for displaying and outputting a warning indicating that the reaction liquid and the cleaning liquid have overflowed from the reaction container (step S4). The control unit 16 may return to step S2 after step S4 and perform the determination process in step S2.

  As described above, the analyzer 301 according to the third embodiment includes the inner lid 321 having the flow path formed by the partition 21a, the region Sh provided with the wall, the concave portion 321g, and the groove 321h. Since the reaction liquid and the cleaning liquid overflowing from can be discharged to the outside through the drainage groove 22, the same effects as those of the first embodiment are obtained.

  Furthermore, the analyzer 301 includes a detection device 323 that can detect overflow of the reaction solution and the cleaning solution by a simple electrode method, and when the detection device 323 determines that the overflow of the reaction solution and the cleaning solution from the reaction container 7 has been detected. Outputs a predetermined warning. Therefore, the operator of the analyzer 301 can immediately recognize that an abnormality has occurred in the nozzles 11a and 11b in the cleaning device 11, and can quickly respond to the abnormality of the cleaning device 11.

  In the third embodiment, an apparatus having the electrodes 323a and 323b has been described as the detection apparatus 323. However, the present invention is not limited to this, and any sensor that can detect the presence or absence of liquid accumulated in the recess 321g may be used. Moreover, in Embodiment 3, although the case where the groove | channel 321h was provided in four places of the outer peripheral area | region of the lid | cover 321 was of course, it may be provided only in one place and may be provided in four places or more. Alternatively, it may be provided only in the vicinity of the cleaning device 11, and it is sufficient if the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 accumulated in the recess 321 g can be poured into the discharge groove 22.

  In the analysis apparatus 301, the case where the display unit 19 displays and outputs a warning has been described as the warning process shown in step S4 of FIG. 17, but the analysis apparatus 301 includes an output unit that outputs sound and the like. May output a warning sound to notify that the reaction liquid and the cleaning liquid overflow from the reaction vessel.

(Embodiment 4)
Next, a fourth embodiment will be described. FIG. 18 is a schematic configuration diagram of an analyzer according to the fourth embodiment. As shown in FIG. 18, the analyzer 401 according to the fourth embodiment includes an inner lid 421 instead of the inner lid 321 shown in FIG. 13. Further, the analyzer 401 has a configuration in which the discharge groove 22 is deleted as compared with the analyzer 301 shown in FIG. Further, the analyzer 401 has a configuration further including a suction device 424 as compared with the analyzer 301 shown in FIG. Note that the control unit 16 also controls the suction device 424.

  Next, the inner lid 421, the detection device 323, and the suction device 424 will be described with reference to FIGS. 19 and 20. FIG. 19 is an enlarged plan view of the rotary table, inner lid, cleaning device, detection device, and suction device of the analyzer shown in FIG. 20 is a cross-sectional view of the rotary table and the inner lid shown in FIG. In FIG. 20, the detection device 323, the suction device 424, the control unit 16, and the display unit 19 are also described for explanation.

  As shown in FIGS. 19 and 20, the inner lid 421 is provided with a lid portion 421c having a recess 321g only in the outer peripheral region Sk, except for the groove 321h, as compared with the inner lid 321 according to the third embodiment. As shown in FIG. 20, the suction device 424 includes a nozzle 424a that sucks the reaction liquid and the cleaning liquid accumulated in the recess 321g, and a tube 424b that guides the reaction liquid and the cleaning liquid sucked by the nozzle 424a to an external discharge unit (not shown). . When the detection device 323 detects that the reaction liquid and the cleaning liquid have accumulated in the recess 321g and the reaction liquid and the cleaning liquid have overflowed from the reaction vessel 7, the suction device 424 sucks the reaction liquid and the cleaning liquid collected in the recess 321g.

  As shown in FIG. 20, the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 through the opening 21b on the inner lid 421 are blocked by the wall of the region Sh, so that not the inner peripheral side of the inner lid 421 but the inner side. It flows to the outer peripheral side of the lid 21. Then, the reaction liquid and the cleaning liquid overflowing from the reaction container 7 are guided into the recess 321g as shown by an arrow Yl in FIG. 20 without being blocked by the partition 21a and entering the adjacent reaction container 7. Then, the reaction liquid and the cleaning liquid accumulated in the recess 321g are sucked by the nozzle 424a of the suction device 424 as shown by the arrow Ym, and are discharged to the outside through the tube 424b as shown by the arrow Yn.

  Next, the processing operation in the analyzer 401 when the reaction liquid and the cleaning liquid overflow from the reaction vessel will be described with reference to FIG. First, as shown in FIG. 21, the controller 16 determines whether or not the detection device 323 has detected an overflow of the reaction liquid and the cleaning liquid from the reaction vessel 7 as in step S2 shown in FIG. S12). The control unit 16 repeats the determination in step S12 until the detection device 323 detects the overflow of the reaction liquid and the cleaning liquid from the reaction vessel 7. When the detection device 323 determines that the overflow of the reaction liquid and the cleaning liquid from the reaction container 7 has been detected (step S12: Yes), the display unit 19 of the control unit 16 is similar to step S4 illustrated in FIG. Under control, a warning process is performed to display and output a warning indicating that the reaction liquid and the cleaning liquid have overflowed from the reaction container (step S14). Then, the suction device 424 performs a suction process of sucking the reaction liquid and the cleaning liquid collected in the recess 321g and discharging them to the outside (step S16). In addition, the control part 16 may return to step S12 after completion | finish of step S16, and may perform the determination process in step S12.

  As described above, the analyzer 401 according to the fourth embodiment includes the suction device 424 that sucks the reaction liquid and the cleaning liquid accumulated in the recess 321 g and discharges them to the outside, so that the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 can be removed. Since it can be discharged to the outside and a warning indicating that the reaction liquid and the cleaning liquid have overflowed from the reaction vessel 7 is output, the same effects as those of the first and third embodiments are obtained.

  In addition, although the case where both the detection device 323 and the suction device 424 are provided as the analysis device 401 according to the fourth embodiment has been described, the configuration is not limited thereto, and a configuration in which the detection device 323 is omitted may be used. In this case, the suction device 424 may always suck and discharge the liquid accumulated in the concave portion 321g, or may suck and discharge the liquid every predetermined time. Also in this case, it is possible to discharge the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 to the outside.

  Further, when the turntable 6 stores a predetermined number of reaction containers and is constituted by a plurality of holder units that can be attached to and detached from the analyzers 1, 301, 401, the inner lid 21, described in the first to fourth embodiments, 221, 321, 421 may be constituted by a plurality of inner lid units having a size corresponding to this holder unit. FIG. 22 shows an inner lid unit 21A constituting the inner lid 21 according to the first embodiment, for example. As shown in FIG. 22, the holder unit 6 f that can be attached to and detached from the rotary table 6 and accommodates a predetermined number of reaction vessels 7 allows measurement light from the photometry device 10 to pass corresponding to the light irradiation region of each reaction vessel 7. A window 6g is provided. The inner lid unit 21A has a size corresponding to the size of the upper surface of the holder unit 6f, and has an opening 21b and a partition 21a corresponding to the number of reaction containers accommodated in the holder unit 6f. Is provided. Similarly to the inner lid 21, the inner lid unit 21A includes a region Sh having a wall and a region Sp having a downward slope, and is screwed into the holder unit 6f via a screw hole 21d and a screw hole in the holder unit 6f. Screwed.

  In addition, the inner lids 21, 221, 321, 421 or the inner lid unit 21A may be attached to the top plate 6b or the holder unit 6f by a fitting such as a hinge in addition to being attached to the top plate 6b or the holder unit 6f by screws 21e. . Furthermore, the inner lid 321 and the inner lid 421 may further include the elastic bodies 221f, 221fa, 221fb in the second embodiment, and the reaction liquid and the cleaning liquid overflowing from the reaction vessel 7 may be reliably discharged to the outside.

  Moreover, in Embodiment 1-4, although the case where the dry bath type thermostat which conducts the heat | fever by a heater to reaction container was used, of course, not only this but the thermostat of predetermined temperature is stored in a thermostat. Similarly, when using a water bath type thermostatic bath that keeps the reaction solution in the reaction vessel by directly immersing the reaction vessel in a constant temperature solution at a predetermined temperature, the reaction solution and washing solution overflowing from the reaction vessel are used. Can be prevented from spreading.

1 is a schematic configuration diagram of an analyzer according to a first embodiment. It is the top view to which the rotary table, the washing | cleaning apparatus, the inner cover, and the drainage groove | channel of the analyzer shown in FIG. 1 were expanded. It is a perspective view which expands and shows a part of rotary table and inner lid shown in FIG.1 and FIG.2. 4 is a cross-sectional view taken along line X1-X1 shown in FIG. FIG. 5 is an enlarged plan view showing a part of the inner lid and the drainage groove shown in FIG. It is sectional drawing of the turntable in the analyzer concerning a prior art. It is sectional drawing of the turntable in the analyzer concerning a prior art. It is the top view to which the rotary table of the analyzer concerning Embodiment 2, a washing | cleaning apparatus, an inner cover, and a drain groove were expanded. It is sectional drawing along the X2-X2 line shown in FIG. It is a top view of the elastic body shown in FIG. It is a top view which shows the other example of the elastic body shown in FIG. It is a top view which shows the other example of the elastic body shown in FIG. FIG. 6 is a schematic configuration diagram of an analyzer according to a third embodiment. It is the top view to which the rotary table of the analyzer shown in FIG. 13, a washing | cleaning apparatus, an inner cover, and a drain groove were expanded. It is sectional drawing along the X3-X3 line shown in FIG. 16 is a cross-sectional view taken along line X4-X4 shown in FIG. It is a flowchart which shows the process sequence when the reaction liquid and the washing | cleaning liquid overflow from the reaction container in the analyzer shown in FIG. FIG. 6 is a schematic configuration diagram of an analyzer according to a fourth embodiment. FIG. 19 is an enlarged plan view of a rotary table, a cleaning device, an inner lid, a detection device, and a suction device of the analyzer shown in FIG. 18. FIG. 20 is a cross-sectional view of the rotary table and the inner lid shown in FIG. It is a flowchart which shows the process sequence when the reaction liquid and the washing | cleaning liquid overflow from the reaction container in the analyzer shown in FIG. FIG. 10 is a perspective view for explaining another example of the inner lid in the first embodiment.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1,301,401 Analyzer 2 Work table 3 Specimen table 3a, 13a Storage chamber 4 Specimen container 5 Specimen dispensing mechanism 6 Rotating table 6a Holder 6b Top plate 6c Constant temperature bath 6d Screw hole 6f Holder unit 6g Window 7 Reaction container 10 Photometry Device 10a Light source 10b Light receiving unit 11 Cleaning device 11a, 11b, 424a Nozzle 11c Cleaning liquid 12 Reagent dispensing mechanism 13 Reagent table 14 Reagent container 15 Reading device 16 Control unit 17 Analyzing unit 18 Input unit 19 Display unit 20 Stirring device 21, 221 321, 421 Inner lid 21a Partition 21b Opening 21c, 321c, 421c Lid 21d Screw hole 21e Screw 21A Inner lid unit 22 Drain groove 22a Drain outlet 22b, 424b Tube 106c Constant temperature liquid 221f, 221fa, 221fb Elastic body Part 321h groove 323 detector 323a, 323b electrode 424 suction device

Claims (10)

In the analyzer for analyzing the reaction liquid by measuring the optical characteristics of the reaction liquid in the reaction container stored in the storage means,
A cleaning means for cleaning the reaction container by injecting and sucking a cleaning liquid into the reaction container for which the measurement of the optical characteristics is completed;
An opening region provided corresponding to an opening portion of the reaction container accommodated in the accommodating means, and the reaction liquid and the cleaning liquid overflowing from the reaction container through the opening region outside the outer wall of the reaction container. A lid that is in close contact with the upper surface of the side wall of the reaction vessel constituting the opening of the reaction vessel,
Discharging means for discharging the reaction liquid and the cleaning liquid guided by the flow path in the lid to the outside of the lid;
An analyzer characterized by comprising:   The analyzer according to claim 1, wherein the lid forms a flow path by providing a partition between each opening region.   The analysis apparatus according to claim 1, wherein the lid forms the flow path by providing a downward slope in a region located on the discharge means side.   The said lid | cover was equipped with the elastic body which seals between the side wall upper surface of the reaction container which comprises the opening part of the said reaction container, and the said cover lower surface. Analysis equipment.   The analyzer according to any one of claims 1 to 4, wherein the lid is provided with a recess for storing the reaction liquid and the washing liquid overflowing from the reaction container to form the flow path. The discharge means is a discharge groove that is provided outside the storage means and discharges the reaction liquid and the cleaning liquid guided by the flow path of the lid to the outside of the lid,
The analyzer according to claim 1, wherein the flow path in the lid guides the reaction liquid and the cleaning liquid overflowing from the reaction container to the discharge groove.   The said discharging means is a suction device that sucks the reaction liquid and the cleaning liquid accumulated in the concave portion and discharges the sucked reaction liquid and the cleaning liquid to the outside of the lid. Analysis equipment. Detecting means for detecting whether or not the reaction liquid and the cleaning liquid have accumulated in the recess;
An output means for outputting a warning indicating that the reaction liquid and the cleaning liquid have overflowed from the reaction container when the detection means detects that the reaction liquid and the cleaning liquid have accumulated in the recess;
The analyzer according to any one of claims 5 to 7, further comprising:   When the detecting unit detects that the reaction liquid and the cleaning liquid are accumulated in the recess, the suction device sucks the reaction liquid and the cleaning liquid accumulated in the recess and discharges the reaction liquid and the cleaning liquid to the outside of the lid. The analyzer according to claim 8. The storage means is configured by a plurality of storage units that store a predetermined number of reaction containers and are detachable from the analyzer.
The analyzer according to any one of claims 1 to 9, wherein the lid is configured by a plurality of lid units having a size corresponding to the storage unit.

Images