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JP2007322285A - Dispensing device - Google Patents

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JP2007322285A
JP2007322285A JP2006153917A JP2006153917A JP2007322285A JP 2007322285 A JP2007322285 A JP 2007322285A JP 2006153917 A JP2006153917 A JP 2006153917A JP 2006153917 A JP2006153917 A JP 2006153917A JP 2007322285 A JP2007322285 A JP 2007322285A
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dispensing
liquid sample
sample
liquid
probe
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Naoya Imai
直也 今井
Hirotaka Kakegawa
宏隆 掛川
Atsushi Matsushita
敦 松下
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Olympus Corp
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Olympus Corp
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Abstract

【課題】分注の良否を判定することで、高精度な分注を可能とした分注装置を提供すること。
【解決手段】プローブ３における静電容量の変化によって液体試料の液面を検知し、プローブによって液体試料を吸引・吐出して分注を行う分注装置１。液体試料を吸引後に検知した液体試料の第１の液面位置と、吸引した液体試料を吐出後、同一の液体試料について吸引前に検知した第２の液面位置との差に基づいて液体試料における分注の良否を判定する判定装置１３が設けられている。
【選択図】 図１Disclosed is a dispensing device that can perform dispensing with high accuracy by determining the quality of dispensing.
A dispensing apparatus 1 detects a liquid surface of a liquid sample by a change in capacitance of a probe 3 and performs dispensing by sucking and discharging the liquid sample with the probe. Based on the difference between the first liquid surface position of the liquid sample detected after the liquid sample is sucked and the second liquid surface position detected before the suction of the same liquid sample after discharging the sucked liquid sample. A determination device 13 is provided for determining whether or not dispensing is good.
[Selection] Figure 1

Description

本発明は、液体試料の分注の良否を判定する判定機能を備えた分注装置に関するものである。   The present invention relates to a dispensing device having a determination function for determining whether or not a liquid sample is dispensed.

従来、試薬を用いて血液等の検体中に含まれる物質の量を分析する自動分析装置においては、正しい分析結果を得るため、検体や試薬等の液体試料を精度よく分注する必要があった。このため、自動分析装置は、通常、液体試料の液面を検知する分注装置を備え、分注装置が検知した液面位置に基づいて液体試料の適切な分注作業を行っている（例えば、特許文献１参照。）。   Conventionally, in an automatic analyzer that analyzes the amount of a substance contained in a sample such as blood using a reagent, it has been necessary to accurately dispense a liquid sample such as a sample or a reagent in order to obtain a correct analysis result. . For this reason, the automatic analyzer normally includes a dispensing device that detects the liquid level of the liquid sample, and performs an appropriate dispensing operation of the liquid sample based on the liquid level position detected by the dispensing device (for example, , See Patent Document 1).

特開２００３−５７０９６号公報JP 2003-57096 A

ところで、上述の自動分析装置は、検体や試薬等の液体試料を分注する際、内蔵した分注装置において、液体試料を吸引・吐出するプローブが液面に接触するときの静電容量の変化に基づいて液体試料の液面を検知している。しかし、自動分析装置は、分析中に液体試料の液面に気泡や膜等、例えば、気泡が存在すると、分注装置がその気泡を液面として誤検知し、分注作業を開始してしまう。この結果、自動分析装置においては、分注装置が液体試料を空気と共に吸い込んでしまい、液体試料の高精度な分注が妨げられ、信頼性のある分析ができなくなる恐れがあった。   By the way, when the above-described automatic analyzer dispenses a liquid sample such as a specimen or a reagent, the capacitance change when the probe for sucking and discharging the liquid sample comes into contact with the liquid surface in the built-in dispensing device. The liquid level of the liquid sample is detected based on the above. However, the automatic analyzer, when a bubble or a film, for example, is present on the liquid surface of the liquid sample during analysis, the dispensing device erroneously detects the bubble as the liquid level and starts dispensing work. . As a result, in the automatic analyzer, the dispensing device sucks the liquid sample together with the air, so that high-precision dispensing of the liquid sample is hindered, and there is a possibility that reliable analysis cannot be performed.

また、自動分析装置においては、液体試料の容器が適正にセットされていないと、液体試料中に気泡が紛れ込んでしまうことから、取扱い説明書に容器の適正なセット方法が注意事項として記載されている。しかし、作業者が分析作業に忙殺されたり、うっかりミス等によって液体試料の容器を適正でない状態にセットすると、液体試料中に気泡が混入する結果、液体試料の液面に気泡が発生してしまい、上記と同様の状況が発生するという問題があった。   Also, in the automatic analyzer, if the container for the liquid sample is not set properly, bubbles will be mixed in the liquid sample, so the instruction manual describes how to set the container properly. Yes. However, if an operator is busy with analysis work, or if the container for the liquid sample is set in an inappropriate state due to a mistake, etc., bubbles will be mixed into the liquid sample, resulting in bubbles on the liquid surface of the liquid sample. There was a problem that the same situation as described above occurred.

この発明は、上述した従来技術による問題点を解消するため、分注の良否を判定することで、高精度な分注を可能とした分注装置を提供することを目的とする。   An object of the present invention is to provide a dispensing apparatus that enables high-precision dispensing by determining the quality of dispensing in order to solve the above-described problems caused by the prior art.

上述した課題を解決し、目的を達成するために、本発明は、プローブにおける静電容量の変化によって液体試料の液面を検知し、前記プローブによって前記液体試料を吸引・吐出して分注を行う分注装置において、前記液体試料を吸引後に検知した前記液体試料の第１の液面位置と、吸引した前記液体試料を吐出後、同一の液体試料について吸引前に検知した第２の液面位置との差に基づいて前記液体試料における分注の良否を判定する判定装置が設けられていることを特徴とする。   In order to solve the above-described problems and achieve the object, the present invention detects the liquid level of a liquid sample by a change in capacitance of the probe, and sucks and discharges the liquid sample by the probe to perform dispensing. In the dispensing apparatus to be performed, the first liquid surface position of the liquid sample detected after the liquid sample is sucked, and the second liquid surface detected before sucking the same liquid sample after discharging the sucked liquid sample A determination device is provided that determines whether the liquid sample is dispensed based on a difference from the position.

本発明にかかる分注装置は、液体試料を吸引後に検知した前記液体試料の第１の液面位置と、吸引した前記液体試料を吐出後、同一の液体試料について吸引前に検知した第２の液面位置との差に基づいて判定装置が前記液体試料における分注の良否を判定するので、気泡等を含む液面の異常を検知して分注の良否を判定することで、高精度な分注を行うことができるという効果を奏する。   The dispensing apparatus according to the present invention includes a first liquid surface position of the liquid sample detected after the liquid sample is sucked, and a second liquid detected before the suction of the same liquid sample after discharging the sucked liquid sample. Since the determination device determines the quality of the dispensing in the liquid sample based on the difference from the liquid level position, it is highly accurate by detecting the abnormality of the liquid level including bubbles or the like and determining the quality of the dispensing. There is an effect that dispensing can be performed.

以下、図面を参照して、この発明に係る分注装置の好適な実施例について説明する。   A preferred embodiment of a dispensing apparatus according to the present invention will be described below with reference to the drawings.

まず、この発明の分注装置に係る実施例について説明する。図１は、この発明の実施例である検体を分注する分注装置の構成を示す図である。分注装置１は、図１に示すように、プローブ３、給排ポンプ５、圧力センサ７、洗浄水ポンプ８、増幅回路１２、判定装置１３、制御回路１４及び入力装置１５を備えている。   First, the Example which concerns on the dispensing apparatus of this invention is described. FIG. 1 is a diagram showing the configuration of a dispensing apparatus that dispenses a sample according to an embodiment of the present invention. As shown in FIG. 1, the dispensing device 1 includes a probe 3, a supply / discharge pump 5, a pressure sensor 7, a washing water pump 8, an amplification circuit 12, a determination device 13, a control circuit 14, and an input device 15.

プローブ３は、管路２によって給排ポンプ５、圧力センサ７及び洗浄水ポンプ８と接続され、検体あるいは試薬を含む液体試料の液面と接触したときに静電容量が変化するステンレス等の導電性素材から形成されている。プローブ３は、駆動手段４によって図中矢印Ａで示す上下方向及び各位置Ｐ1〜Ｐ4に移動され、液体試料の液面との相対位置に基づく静電容量の変化を判定装置１３に出力する。ここで、管路２は、合成樹脂からなる可撓性を有する内径２〜３ｍｍのパイプが使用されている。また、位置Ｐ1には、検体が入ったサンプルカップ２０が、位置Ｐ2には、サンプルカップ２０から分注した検体を吐出する分注容器２１が、それぞれ配置されている。位置Ｐ3には、プローブ３を洗浄した洗浄水１１を吐出する洗浄容器２２が、位置Ｐ4には、洗浄水１１では洗浄しきれないときに、プローブ３を洗浄する洗剤が入った洗剤カップ２３が、それぞれ配置されている。この洗剤によるプローブ３の洗浄は選択に基づいて実行される。一方、駆動手段４は、後述するＣＰＵ１３ｂからの指令に基づいて作動が制御され、プローブ３を位置Ｐ1〜Ｐ4に移動すると共に、プローブ３の先端を所定深さまで液体試料中に侵入させる。   The probe 3 is connected to the supply / discharge pump 5, the pressure sensor 7 and the washing water pump 8 by the pipe line 2, and is electrically conductive such as stainless steel whose capacitance changes when it comes into contact with the liquid surface of the liquid sample containing the specimen or the reagent. It is formed from a sex material. The probe 3 is moved by the driving means 4 in the vertical direction indicated by the arrow A in the figure and each of the positions P1 to P4, and outputs a change in capacitance based on the relative position of the liquid sample to the liquid surface to the determination device 13. Here, the pipe 2 is a flexible pipe made of synthetic resin and having an inner diameter of 2 to 3 mm. In addition, a sample cup 20 containing a sample is disposed at the position P1, and a dispensing container 21 for discharging the sample dispensed from the sample cup 20 is disposed at the position P2. A cleaning container 22 that discharges the cleaning water 11 that has cleaned the probe 3 is located at the position P3, and a detergent cup 23 that contains a detergent that cleans the probe 3 when the cleaning water 11 cannot be cleaned at the position P4. , Each is arranged. The cleaning of the probe 3 with this detergent is executed based on the selection. On the other hand, the operation of the driving unit 4 is controlled based on a command from the CPU 13b described later, and the probe 3 is moved to positions P1 to P4 and the tip of the probe 3 is penetrated into the liquid sample to a predetermined depth.

給排ポンプ５は、プローブ３に液体試料を吸引・吐出させるシリンジで、ポンプ駆動手段６によってピストン５ａが往復動される。   The supply / discharge pump 5 is a syringe that causes the probe 3 to suck and discharge the liquid sample, and the piston 5 a is reciprocated by the pump driving means 6.

圧力センサ７は、給排ポンプ５によって液体試料を吸引・吐出する際の管路２内における液体試料の圧力を検知し、圧力信号（アナログ）として増幅回路１２へ出力する。   The pressure sensor 7 detects the pressure of the liquid sample in the pipe line 2 when the liquid sample is aspirated / discharged by the supply / discharge pump 5 and outputs the pressure to the amplifier circuit 12 as a pressure signal (analog).

洗浄水ポンプ８は、タンク１０に貯留された脱気した洗浄水１１を吸い上げて圧力センサ７との間に設けた電磁弁９を介して管路２内に圧送する。このとき、電磁弁９は、吸い上げた洗浄水１１を管路２内に圧送するときは「開」に切り替えられ、給排ポンプ５によってプローブ３が液体試料を吸引・吐出するときは「閉」に切り替えられる。   The washing water pump 8 sucks up the degassed washing water 11 stored in the tank 10 and pumps it into the pipe line 2 through an electromagnetic valve 9 provided between the washing water pump 8 and the pressure sensor 7. At this time, the electromagnetic valve 9 is switched to “open” when the sucked wash water 11 is pumped into the pipe 2, and “closed” when the probe 3 sucks and discharges the liquid sample by the supply / discharge pump 5. Can be switched to.

増幅回路１２は、圧力センサ７から出力される圧力信号（アナログ）を増幅し、増幅した圧力信号を判定装置１３へ出力する。   The amplifier circuit 12 amplifies the pressure signal (analog) output from the pressure sensor 7 and outputs the amplified pressure signal to the determination device 13.

判定装置１３は、液体試料の分注の良否を判定するもので、Ａ／Ｄ変換器１３ａ、ＣＰＵ１３ｂ、記憶装置１３ｃ及び静電容量検出回路１３ｄを備えている。Ａ／Ｄ変換器１３ａは、増幅回路１２から入力される圧力信号（アナログ）をデジタル信号に変換する。ＣＰＵ１３ｂは、記憶装置１３ｃから読み出した制御信号に基づいて駆動手段４の作動によるプローブ３の上下方向並びに位置Ｐ1〜Ｐ4への位置決めを制御すると共に、静電容量検出回路１３ｄから出力される静電容量信号と記憶装置１３ｃから読み出される駆動手段４の制御信号とに基づき、液体試料を吸引後に検知した液体試料の第１の液面位置、吸引した液体試料を吐出後、同一の液体試料について吸引前に検知した第２の液面位置及び両液面位置の差ΔＨを、それぞれ演算し、第１及び第２の液面位置とその差ΔＨとを液面情報信号として記憶装置１３ｃへ出力する。記憶装置１３ｃは、プローブ３によって液体試料を吸引・吐出する際の管路２内における洗浄水１１の圧力に関する所定の閾値、駆動手段４の制御信号及びＣＰＵ１３ｂから出力された前記液面情報信号並びに予め設定された前記液面位置の差ΔＨに関する閾値ΔＨtを格納している。静電容量検出回路１３ｄは、プローブ３と液体試料の液面との相対位置に基づく静電容量の変化を検知し、検知した静電容量信号をＣＰＵ１３ｂに出力する。   The determination device 13 determines whether or not the liquid sample is dispensed, and includes an A / D converter 13a, a CPU 13b, a storage device 13c, and a capacitance detection circuit 13d. The A / D converter 13a converts the pressure signal (analog) input from the amplifier circuit 12 into a digital signal. The CPU 13b controls the positioning of the probe 3 in the vertical direction and the positions P1 to P4 by the operation of the driving unit 4 based on the control signal read from the storage device 13c, and outputs the electrostatic output from the capacitance detection circuit 13d. Based on the capacity signal and the control signal of the driving unit 4 read from the storage device 13c, the first liquid surface position of the liquid sample detected after the liquid sample is aspirated, the aspirated liquid sample is ejected, and the same liquid sample is aspirated The previously detected second liquid surface position and the difference ΔH between both liquid surface positions are calculated, respectively, and the first and second liquid surface positions and the difference ΔH are output to the storage device 13c as a liquid surface information signal. . The storage device 13c has a predetermined threshold value regarding the pressure of the cleaning water 11 in the pipe line 2 when the liquid sample is sucked and discharged by the probe 3, a control signal of the driving means 4, the liquid level information signal output from the CPU 13b, and Stored is a threshold value ΔHt relating to the liquid level position difference ΔH set in advance. The capacitance detection circuit 13d detects a change in capacitance based on the relative position between the probe 3 and the liquid surface of the liquid sample, and outputs the detected capacitance signal to the CPU 13b.

制御回路１４は、入力装置１５から入力された情報と判定装置１３から入力される情報とに基づいて駆動手段４，ポンプ駆動手段６，洗浄水ポンプ８及び電磁弁９の動作を制御する。   The control circuit 14 controls the operation of the driving means 4, the pump driving means 6, the washing water pump 8 and the electromagnetic valve 9 based on the information input from the input device 15 and the information input from the determination device 13.

入力装置１５は、前記閾値等を入力するキーボード等で、例えば、増幅回路１２及び判定装置１３と共に、ディスプレイ装置を備えたパーソナルコンピュータとして一体化したものであってもよい。   The input device 15 may be a keyboard that inputs the threshold value or the like, and may be integrated as a personal computer including a display device together with the amplifier circuit 12 and the determination device 13, for example.

以上のように構成される分注装置１は、以下のように使用される。先ず、電磁弁９を開の状態にして洗浄水ポンプ８によってタンク１０内の洗浄水１１を管路２内に圧送し、プローブ３の先端に空気層を所定量残して洗浄水１１を満たす。   The dispensing device 1 configured as described above is used as follows. First, the electromagnetic valve 9 is opened and the cleaning water 11 in the tank 10 is pumped into the pipe line 2 by the cleaning water pump 8, and a predetermined amount of air layer is left at the tip of the probe 3 to fill the cleaning water 11.

次に、電磁弁９を閉の状態に切り替え、駆動手段４によってプローブ３をサンプルカップ２０が配置された位置Ｐ1に位置決めした後、下降させ、プローブ３の先端をサンプルカップ２０の検体中に所定量侵入させる。   Next, the electromagnetic valve 9 is switched to the closed state, the probe 3 is positioned by the driving means 4 at the position P1 where the sample cup 20 is disposed, and then lowered, and the tip of the probe 3 is placed in the sample of the sample cup 20. Make a constant intrusion.

次いで、ポンプ駆動手段６によって給排ポンプ５のピストン５ａを引き、プローブ３内に検体を所定量吸い込む。このとき、検体は、洗浄水１１との間に前記空気層が介在した状態で吸い込まれるので、洗浄水１１と混ざり合うことはない。   Next, the piston 5 a of the supply / discharge pump 5 is pulled by the pump driving means 6, and a predetermined amount of sample is sucked into the probe 3. At this time, since the specimen is sucked in with the air layer interposed between the cleaning water 11 and the cleaning water 11, the specimen is not mixed with the cleaning water 11.

しかる後、駆動手段４によってプローブ３を上昇させ、分注容器２１が配置された位置Ｐ2にプローブ３を位置決めした後、再び下降させ、ポンプ駆動手段６によって給排ポンプ５のピストン５ａを押してプローブ３内に吸い込んだ検体を分注容器２１に吐出する。   Thereafter, the probe 3 is raised by the driving means 4, the probe 3 is positioned at the position P2 where the dispensing container 21 is disposed, and then lowered again, and the piston 5a of the supply / discharge pump 5 is pushed by the pump driving means 6 to probe. The sample sucked into 3 is discharged into the dispensing container 21.

そして、駆動手段４によってプローブ３を上昇させ、洗浄容器２２が配置された位置Ｐ3にプローブ３を位置決めした後、再び下降させ、電磁弁９を開の状態に切り替える。そして、洗浄水ポンプ８を駆動してタンク１０内の洗浄水１１を管路２内に圧送し、プローブ３から洗浄容器２２に吐出させてプローブ３を洗浄水１１で洗浄することで、１つの検体の分注作業が完了する。このとき、プローブ３を洗浄水１１で洗浄しきれないときには、洗剤でプローブ３を洗浄することもある。一方、他の検体を分注するときには、以上の動作を繰り返すことにより、新たなサンプルカップ２０から新たな分注容器２１に順次新たな検体を分注してゆく。   Then, the probe 3 is raised by the driving means 4, the probe 3 is positioned at the position P3 where the cleaning container 22 is disposed, and then lowered again to switch the electromagnetic valve 9 to the open state. Then, the cleaning water pump 8 is driven to pump the cleaning water 11 in the tank 10 into the pipe line 2, and is discharged from the probe 3 to the cleaning container 22 to clean the probe 3 with the cleaning water 11. Sample dispensing work is completed. At this time, if the probe 3 cannot be washed with the washing water 11, the probe 3 may be washed with a detergent. On the other hand, when another sample is dispensed, a new sample is sequentially dispensed from a new sample cup 20 to a new dispensing container 21 by repeating the above operation.

このとき、分注装置１においては、判定装置１３が以下のようにして分注の良否を判定する。   At this time, in the dispensing device 1, the determination device 13 determines the quality of dispensing as follows.

先ず、ＣＰＵ１３ｂは、検体を所定量吸い込んだプローブ３が上昇し、サンプルカップ２０の液面から離れる吸引後に検知した検体の第１の液面位置Ｌs1、吸引した検体を吐出後、プローブ３が下降してきて同一の検体について吸引前に検知した第２の液面位置Ｌs2及び両液面位置の差ΔＨ（＝Ｌs2−Ｌs1）を、静電容量検出回路１３ｄから出力される静電容量信号と記憶装置１３ｃから読み出される駆動手段４の制御信号とに基づいて演算する。このとき、検体に気泡等が発生せず、分注が良好に実行されていれば差ΔＨ＝０となる。   First, the CPU 13b raises the probe 3 that has sucked a predetermined amount of the sample, and after the aspirated sample is discharged, the probe 3 is lowered after the first liquid surface position Ls1 of the sample detected after aspiration away from the liquid surface of the sample cup 20 is discharged. Then, the second liquid level position Ls2 detected for the same specimen before aspiration and the difference ΔH (= Ls2−Ls1) between the two liquid level positions and the capacitance signal output from the capacitance detection circuit 13d are stored. It calculates based on the control signal of the drive means 4 read from the apparatus 13c. At this time, if no bubbles or the like are generated in the sample and the dispensing is performed well, the difference ΔH = 0.

これに対し、図２に示すように、検体を所定量吸い込んだプローブ３が上昇した後、サンプルカップ２０の検体に気泡Ｂが存在すると、吸引した検体を吐出後、吸引前に同一の検体に関してＣＰＵ１３ｂによって演算される第２の液面位置Ｌs2は、気泡Ｂの存在によって第１の液面位置Ｌs1とは異なり、両液面位置の差ΔＨ＞０となる。このため、記憶装置１３ｃには、許容誤差等を考慮した閾値ΔＨtを予め記憶させておく。この場合、閾値ΔＨtは、前記許容誤差の他、試薬や検体等の粘性等によって異なり、個々の液体試料について決められる。   On the other hand, as shown in FIG. 2, when the bubble 3 is present in the sample of the sample cup 20 after the probe 3 that has sucked a predetermined amount of the sample is raised, The second liquid level position Ls2 calculated by the CPU 13b differs from the first liquid level position Ls1 due to the presence of the bubbles B, and the difference ΔH> 0 between the two liquid level positions. For this reason, the storage device 13c stores in advance a threshold value ΔHt in consideration of an allowable error or the like. In this case, the threshold value ΔHt differs depending on the viscosity of the reagent or the specimen in addition to the tolerance, and is determined for each liquid sample.

そして、ＣＰＵ１３ｂは、記憶装置１３ｃから読み出した閾値ΔＨtと実測された差ΔＨとを比較し、前記液面位置の差ΔＨが閾値ΔＨt以内であれば、検体の分注を良と判定し、閾値ΔＨtを超えていれば、検体の分注を不良と判定する。このように、分注装置１は、分注する液体試料を収容した容器の形状や分注量に関係なく、分注の良否を判定装置１３によって判定することができる。この場合、分注装置１においては、サンプルカップ２０等の液体試料の容器は、内容量が減少しても、液面形状が変化しない範囲で使用することが好ましいが、液面形状が変化する場合には、予め液面位置の変化量も考慮して分注の良否を判定するようにする。   Then, the CPU 13b compares the threshold value ΔHt read from the storage device 13c with the actually measured difference ΔH, and if the difference ΔH in the liquid level position is within the threshold value ΔHt, the CPU 13b determines that the sample is dispensed. If ΔHt is exceeded, the dispensing of the specimen is determined to be defective. Thus, the dispensing device 1 can determine the quality of dispensing by the determination device 13 regardless of the shape of the container containing the liquid sample to be dispensed and the dispensing amount. In this case, in the dispensing apparatus 1, it is preferable to use the liquid sample container such as the sample cup 20 within a range in which the liquid level shape does not change even if the internal volume decreases, but the liquid level shape changes. In this case, the quality of dispensing is determined in advance in consideration of the amount of change in the liquid level position.

このようにして判定された分注の良否に基づき、分注装置１においては、分注不良と判定されたときには、警報や分注不良マークが制御回路１４から表示装置（図示せず）に出力される。このような分注不良が発生した場合、オペレータは、マニュアル操作によってプローブを引き上げて容器を取り出し、内部の気泡を除去した後、改めて分注操作を行う。   Based on the quality of the dispensing thus determined, in the dispensing device 1, when it is determined that the dispensing is defective, an alarm or a dispensing failure mark is output from the control circuit 14 to the display device (not shown). Is done. When such a dispensing failure occurs, the operator pulls up the probe by manual operation, takes out the container, removes bubbles inside, and then performs the dispensing operation again.

以上のように、本発明にかかる分注装置は、液体試料の分注に有用であり、特に、自動分析装置での使用に適している。   As described above, the dispensing apparatus according to the present invention is useful for dispensing a liquid sample, and is particularly suitable for use in an automatic analyzer.

本発明の実施例である分注装置の構成を示す図である。It is a figure which shows the structure of the dispensing apparatus which is an Example of this invention. 図１の分注装置における分注の良否の判定を説明する図である。It is a figure explaining the determination of the quality of dispensing in the dispensing apparatus of FIG.

符号の説明Explanation of symbols

１ 分注装置
２ 管路
３ プローブ
４ 駆動手段
５ 給排ポンプ
５ａ ピストン
６ ポンプ駆動手段
７ 圧力センサ
８ 洗浄水ポンプ
９ 電磁弁
１０ タンク
１１ 洗浄水
１２ 増幅回路
１３ 判定装置
１３ａ Ａ／Ｄ変換器
１３ｂ ＣＰＵ
１３ｃ 記憶装置
１３ｄ 静電容量検出回路
１４ 制御回路
１５ 入力装置
２０ サンプルカップ
２１ 分注容器
２２ 洗浄容器
２３ 洗剤カップ
Ｌs1 第１の液面位置
Ｌs2 第２の液面位置
Ｐ1〜Ｐ4 位置 DESCRIPTION OF SYMBOLS 1 Dispensing apparatus 2 Pipe line 3 Probe 4 Driving means 5 Supply / discharge pump 5a Piston 6 Pump driving means 7 Pressure sensor 8 Washing water pump 9 Electromagnetic valve 10 Tank 11 Washing water 12 Amplifying circuit 13 Judgment device 13a A / D converter 13b CPU
13c Storage device 13d Capacitance detection circuit 14 Control circuit 15 Input device 20 Sample cup 21 Dispensing container 22 Cleaning container 23 Detergent cup Ls1 First liquid level position Ls2 Second liquid level position P1 to P4 position

Claims (1)

プローブにおける静電容量の変化によって液体試料の液面を検知し、前記プローブによって前記液体試料を吸引・吐出して分注を行う分注装置において、
前記液体試料を吸引後に検知した前記液体試料の第１の液面位置と、吸引した前記液体試料を吐出後、同一の液体試料について吸引前に検知した第２の液面位置との差に基づいて前記液体試料における分注の良否を判定する判定装置が設けられていることを特徴とする分注装置。 In a dispensing device that detects the liquid level of a liquid sample by a change in capacitance in the probe, and performs dispensing by sucking and discharging the liquid sample by the probe,
Based on the difference between the first liquid level position of the liquid sample detected after aspiration of the liquid sample and the second liquid level position detected before aspiration of the same liquid sample after discharging the aspirated liquid sample. And a determination device for determining whether or not the liquid sample is dispensed is provided.
JP2006153917A 2006-06-01 2006-06-01 Dispensing device Pending JP2007322285A (en)

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