JP2007309852A - Prepared slide, and apparatus and method for controlling the prepared slide - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a prepared slide which is user-friendly and controlled easily and enables inspection and diagnosis to be carried out easily from a remote place, and to provide a prepared slide controlling apparatus. <P>SOLUTION: The prepared slide has an RFID tag device and a positioning closure line indicated around a region on which a sample is placed. The prepared slide controlling apparatus comprises an RFID tag reading means; a digital camera for photographing the image of the prepared slide as a whole; a microscope enabling photographing to be carried out under external control and by using a microscope camera; an electrically-operated stage which can move the prepared slide; and a computer for controlling the entirely. When a desired part in the displayed image as a whole is clicked simply by using a mouse, since the electrically-operated stage is controlled, a high-magnification image of the part is displayed, and positional information and an optional microscopic image are recorded, the user-friendliness and repeatability are improved significantly. <P>COPYRIGHT: (C)2008,JPO&INPIT

Description

  TECHNICAL FIELD The present invention relates to a preparation, a preparation management apparatus, and a preparation management method, and in particular, a preparation, a preparation management apparatus, and a preparation management method that are easy to operate, easy to manage, and easily inspected and diagnosed from a remote location. It is about.

  Some surgeries require a pathological diagnosis during surgery by a specialist. In the pathological diagnosis, a lesion is removed, and a sliced tissue is enlarged with a microscope to diagnose the cell shape and arrangement. Specifically, there are cases where a clinician confirms with a pathologist during surgery how far a cancer cell should be removed.

  Conventionally, when a pathological diagnosis is performed in a hospital, a tissue collected from a patient is placed on a slide, and a specialized pathologist makes a diagnosis with a microscope. In diagnosis, first, the objective lens of the microscope is focused at a low magnification, the focus is adjusted, and the preparation is moved in the XY directions to check the image of the entire tissue. Next, the portion to be diagnosed is determined, the target portion is aligned with the center of the optical axis of the microscope, the magnification of the objective lens is increased to focus, and the detailed portion is verified and diagnosed. If further detailed analysis is required, a higher magnification objective lens is selected and the same operation is repeated.

  The following Patent Document 1 discloses a sample inspection system capable of performing a sample inspection by easily preventing a patient from being mistaken for a living body without performing troublesome work. In this system, the collected tissue is attached to a slide with a non-contact ID tag attached in advance, and the specimen is prepared by staining and covering with a cover glass.

Then, by inserting the patient's magnetic card examination ticket into the information transmission BOX and turning on the transmission switch, the patient information is read from the magnetic card examination ticket and temporarily stored in the memory unit in the information transmission BOX, It is written from the antenna to the storage unit inside the non-contact ID tag. Therefore, even when a preparation is sent and pathological diagnosis is performed, by reading out the patient information written in the storage section of the preparation, it is possible to surely know which patient the sample belongs to and to make a mistake. Can be prevented.
JP 2003-111733 A

  In addition, since there are very few pathologists who perform pathological diagnosis, there are many hospitals where pathologists are not resident even in hospitals that frequently perform surgery. Therefore, there are cases where a pathologist goes to the hospital and performs an operation according to the day or performs an operation twice. In order to solve this problem, conventionally, a preparation is placed on a microscope that can take an image and can be operated remotely, and a pathologist operates the microscope from a remote location, and makes a pathological diagnosis by looking at the transmitted microscope image of the preparation. Research and development of systems that can be performed has been conducted.

  In the preparation management system as described above, since patient information is written in the preparation ID tag, it is necessary to use a writable tag, which is expensive. In addition, there is a problem that a specific preparation cannot be easily extracted from a large number of preparations even if tags are attached.

  In the case of pathological diagnosis, a certain degree of diagnosis can be made by observing the entire preparation tissue, and it can be determined which part of the tissue should be observed with a microscope. However, in the remote diagnosis as described above, the microscope has a problem that the magnification is too high and an image of the whole tissue of the slide cannot be taken, and the pathological diagnosis takes time and effort.

It is conceivable to take high-resolution images of all parts of the preparation in advance, but because the images also require information in the Z-axis direction, it takes a lot of time and effort to shoot high-resolution images. In addition, there is a problem that a huge amount of image data must be transferred and stored.
An object of the present invention is to provide a preparation, a preparation management device, and a preparation management that solve the above-described problems of the prior art, have good operability, are easy to manage, and can be easily inspected and diagnosed from a remote location. It is to provide a method.

  The preparation of the present invention includes an RFID tag means for transmitting unique ID information stored in response to a read command from the outside, and an outer frame for positioning displayed on at least a part of the periphery of the region on which the sample is placed The main feature is that it is provided with means. Further, the above-described preparation is characterized in that it includes a display unit that emits light or changes color in response to a display command from the outside. Also, the above-mentioned preparation is characterized in that it has a structure in which a plastic plate having the RFID tag means and the outer frame means and having an opening in which a sample is placed is bonded to a glass plate. is there.

  The preparation management apparatus according to the present invention includes an RFID tag reading unit that reads ID information from a preparation, a digital camera unit that captures an entire image of a preparation sample, and a microscope camera that can be controlled from the outside and is mounted. Microscope means capable of photographing, electric stage means connected to the microscope means and capable of moving the preparation in a desired direction, the RFID tag reading means, the digital camera means, the microscope means, and the electric stage means are controlled. The main feature is that it comprises computer means.

  In the preparation management apparatus described above, the microscope means is further connected to the computer means via a communication means, displays a microscope image sent from the computer means, and transmits control information of the microscope means to the computer means. The second computer means is also characterized.

  Further, the preparation management apparatus described above further includes server means for storing an entire image of the preparation photographed by the digital camera means and transmitting it to the second computer means in response to a request. is there.

  In the preparation management apparatus described above, the computer means controls the microscope means based on the control information received from the second computer means, and periodically captures an image from the microscope camera, and the second means. The second computer means has a function of displaying the entire image acquired from the server means and generating control information of the microscope means based on a click position on the image. There is also a feature in the point.

  The preparation management method of the present invention includes a step of reading and displaying an entire image of a stored preparation, a step of acquiring position information of a clicked location on the entire image, and a microscope in which the preparation is set based on the position information. Calculating the control information of the electric stage for matching the optical axis of the clicked position, moving the electric stage so that the optical axis of the microscope matches the clicked position, and displaying the microscope image Is the main feature.

The preparation, preparation management apparatus, and preparation management method of the present invention have the following effects.
(1) The preparation and the patient can be associated with each other by a simple operation, and the patient can be prevented from being mixed up.
(2) Since the entire image has been captured in advance by the camera, if a high magnification is not required, the stored entire image is read and displayed, and a certain degree of judgment can be made by simply increasing the magnification as necessary. It becomes possible.
(3) Even when a high-magnification image is required, the stage can be moved continuously and freely from a remote place in the same way as an actual microscope, and pathological diagnosis from a remote place can be performed easily and quickly. .

(4) Just by clicking the desired part of the displayed whole image with the mouse, the motorized stage is controlled, a high-magnification image of that part is displayed, and positional information and, if necessary, a microscopic image are recorded. Therefore, operability and reproducibility are dramatically improved.
(5) Since the preparation can be easily extracted from the storage location by the LED incorporated in the preparation, the preparation can be easily retrieved and extracted.
(6) A past pathological diagnosis image diagnosed by a pathologist can be easily read.

  Embodiments of the present invention will be described below in detail with reference to the drawings.

  The first embodiment of the present invention will be described below. FIG. 1 is a block diagram showing the hardware configuration of the entire system including the apparatus of the present invention. In the embodiment, an example will be described in which a tissue is collected from a patient at Hospital A 35 to create and manage a preparation, and a pathologist at Hospital B 45 performs remote diagnosis of the preparation. For example, it can be performed in an operating room and a pathologist's office in the same hospital.

  The A hospital 35 is provided with a known hospital information system 34 also called HIS. This HIS includes a LAN 32 and a router 33. The PC 10 and the preparation management server 30 according to the present invention are connected to, for example, the LAN 32, and each device connected to the LAN 32 and the Internet 35 or any other high-speed communication network or communication line can be connected to an external device. It is configured to be possible.

  The PC 10 is obtained by installing a program related to the present invention described later on a known personal computer. Connected to the PC 10 is a display such as a known display device, keyboard, mouse, input device 11, magnetic card reader 12, portable RFID tag reader 13, digital camera 20, tag reader 21, microscope 25, microscope camera 26, and electric XY stage 27. Has been.

  The magnetic card reader 12 is used to read the ID information from the patient's examination ticket, and the portable RFID tag reader 13 reads the ID of the preparation to be examined, or manually scans the preparation storage shelf 14 in which a large number of preparations are stored. And used to detect and extract the desired preparation.

  The digital camera 20 is fixed to a table, and captures the entire image of the slide as one image. Also, a tag reader 21 is built in the stand, and the ID of the preparation is read when the digital camera 20 takes a picture, and is recorded corresponding to the image. Note that the tag reader 21 may be omitted and the portable RFID tag reader 13 may read the ID.

  The microscope 25 can directly observe the preparation with the naked eye and includes a microscope camera 26 so that a microscope image can always be output. In addition, the magnification, focus, and the like can be controlled from the PC 10. Furthermore, an electric XY stage 27 capable of moving the preparation in a desired biaxial direction is provided, and the electric XY stage 27 is configured to be controlled from the PC 10.

  Note that such an externally controllable microscope is known. The electric XY stage 27 may have the same function as the tag reader 21.

  The preparation management server 30 is obtained by installing a program to be described later on a known server device, and includes a database (DB) 31. The DB 31 stores a whole image photographed by the digital camera 20 using the preparation ID information as a key, a microscope image photographed by the microscope camera 26 at the time of diagnosis, diagnostic information such as an inspection result, and the like.

  For example, a remote PC 40 connected to the Internet 35 is installed at the hospital B where the pathologist is located. The remote PC 40 is connected to a remote control console 43 in addition to a known keyboard, mouse 42 and display device 41. Yes. The microscope remote control console 43 has a shape similar to that of the microscope 25, and includes a magnification switching knob, a focus, a slide movement knob in the XY-axis direction, and the like. The operation amounts of these knobs are detected by a rotary encoder or the like and output to the remote PC 40.

  FIG. 2 is a plan view and a cross-sectional view showing the structure of the preparation 50 of the present invention. The preparation 50 is obtained by bonding a thin plate-like cover 51 made of plastic with an adhesive or the like on a preparation 50 which is a conventional glass plate serving as a base. A window (opening) 52 is provided in a portion where the central structure of the cover 51 is placed and the cover glass 59 is covered.

  An RFID tag chip 56, a display light emitting diode (LED) 57, and a loop antenna 58 connected to the RFID tag chip 56 are embedded in the cover 51. The LED 57 is mounted so as to emit light in a longitudinal direction parallel to the surface of the preparation.

  An outer frame 53 that is a line for detecting the origin position from the image is printed or stamped around the window (opening) 52. Further, a handwriting area 55 and a printing area 54 are provided on the left and right surfaces of the cover 51. In this area, a sticker is attached to the surface so that handwriting or printing can be performed, or very fine irregularities are provided on the surface. It is.

  FIG. 3 is a sectional view showing the structure of another embodiment of the preparation 50 of the present invention. (A) does not use a conventional glass preparation, and the entire preparation is composed of a plastic plate 60. An RFID tag chip 56, an LED 57, and an antenna 58 are embedded inside the plate 60. If the surface of the plate 60 is glass-coated, durability against chemicals is improved.

  (B) is obtained by bonding a thin plate-like cover 51 made of plastic to the lower surface of a glass preparation 50 with an adhesive or the like. By disposing the cover 50 on the lower surface, since the upper surface is entirely made of glass, preparation of a preparation is easy and durability against chemicals is improved. In addition, since handwriting etc. can be performed from the front side, you may stick the stickers 61 and 62 which can be handwritten or printed in a handwriting area | region or a printing area.

(C) shows a structure in which a glass plate 65 serving as a stage on which a tissue is placed is sandwiched between two plastic plates 63 and 64. There is no need to bond the glass plate and the plastic plate, and the two plastic plates can be easily manufactured by fitting them with a nail, a hole or a step.

  FIG. 4 is a block diagram of a preparation having the RFID tag function of the present invention. An output signal of a tuning circuit (antenna) 70 that performs communication and power supply is rectified by a rectifier circuit 71 and charges a capacitor 72. When the voltage detection circuit 73 detects a voltage at which the CPU 74 can operate, the voltage detection circuit 73 sends a reset signal to the CPU 74 to activate the CPU 74.

  The CPU 74 receives a signal from the signal transmission / reception circuit 77 based on a program stored in the ROM 75, analyzes a command from an external reader, and signals unique ID information stored in the ROM 74 according to the command. Transmission is performed via the transmission / reception circuit 77. The RAM 76 is used for work. Note that RFID tags having the above functions are known.

  The RFID tag circuit of the present invention further includes a booster circuit 80 and a capacitor 81, a current limiting resistor 82, an LED 83 (57), and a switching FET 84. The booster circuit 80 boosts the voltage charged in the capacitor 72 to a voltage necessary for lighting the LED, and charges the capacitor 81.

  When the CPU 74 turns on the FET 84 based on a command from the outside, a current flows from the capacitor 81 through the resistor 82, the LED 83 (57), and the FET 84, and the LED 83 (57) is lit. The LED 83 (57) blinks by periodically transmitting a lighting command from the outside.

  FIG. 5 is a block diagram of another embodiment of a preparation having the RFID tag function of the present invention. The difference from FIG. 4 is that a booster circuit 80, a capacitor 81, a drive circuit 85, and an EL element 86 are provided, and the other configurations are the same. The EL (Electro Luminesence) element 86 needs to be driven with an alternating current of several tens of volts. Accordingly, the booster circuit 80 boosts the voltage to a voltage necessary for driving the EL element 86, the drive circuit 85 performs on / off control and conversion to alternating current, and the EL element 86 is lit.

  FIG. 6 is a flowchart showing the contents of processing in the PC 10. In this embodiment, it is assumed that a high-speed connection is established between the PC 10 and the remote PC 40 by a known method. In S10, a microscope camera image is captured. In S11, the latest captured image is transmitted to the remote PC 40. Usually, the microscope image is displayed / updated on the display device of the remote PC 40 almost in real time by repeating the processes of S10 and S11 as fast as possible.

  In S12, it is determined whether a microscope control instruction is received from the remote PC 40. If the determination result is negative, the process proceeds to S14, but if the determination is affirmative, the process proceeds to S13. In S13, the magnification of the microscope 25, the focus, the electric XY stage 27, and the like are controlled based on control information received from the microscope remote control console 43 or the keyboard and mouse 42 via the remote PC 40 and the Internet 35.

  In S14, for example, it is determined whether or not a preparation search instruction is input from the keyboard. If the determination result is negative, the process proceeds to S16, but if the determination is affirmative, the process proceeds to S15. In S15, a later-described preparation search process is executed.

  In S16, for example, it is determined whether or not an execution request for processing necessary for setting a slide is set from the keyboard to the XY stage 27 of the microscope. If the determination result is negative, the process proceeds to S20. In this case, the process proceeds to S17. In S17, the preparation ID is read by the portable RFID tag reader 13 or the tag reader incorporated in the electric XY stage.

  In S18, the microscope is set to the minimum magnification, the XY stage 27 is moved to a position where the outer frame is estimated to exist, and an image including the outer frame 53 of the slide is photographed. In S19, the outer frame line 53 is detected from the image by a known recognition method, and the coordinate origin position (for example, the upper left corner of the outer frame) on the XY stage is recognized and recorded. If there is no outer frame at the estimated position, S18 and 19 are repeated to search the surroundings.

  In S20, for example, it is determined whether or not a microscope image storage instruction has been received from the remote PC 40. If the determination result is negative, the process proceeds to S24, but if the determination is affirmative, the process proceeds to S21. In S21, the read latest microscope image is acquired. In S22, microscope state information such as magnification, focus position, and stage position information is acquired. In S23, the microscope image, the microscope state information, the preparation ID, and the like are transmitted as a set to the preparation management server 30.

  In S24, for example, it is determined whether or not a digital camera shooting instruction is input from the keyboard. If the determination result is negative, the process returns to S10, but if the determination is positive, the process proceeds to S25. In S <b> 25, the entire image including the outer frame of the slide captured by the digital camera 20 is captured.

  In S26, the outer frame line is detected from the entire image by a known method, and the coordinate origin position on the image is recognized and recorded. In S27, the preparation ID is read by the tag reader 21. In S28, the patient ID is read by the magnetic card reader 12 from the patient's examination ticket or input from the keyboard. In S29, the whole image, the origin position information on the image, the preparation ID, the patient ID, and the like are transmitted as a set to the preparation management server 30.

  FIG. 7 is a flowchart showing the contents of processing in the remote PC 40. In S40, the ID of the preparation currently set on the XY stage of the microscope is acquired from the PC 10. In S41, the corresponding whole image data is acquired from the preparation management server 30 based on the acquired preparation ID and displayed.

  In S42, the origin position data of the entire image is acquired from the preparation management server 30. In S43, it is determined whether a microscope image has been received from the PC 10, and if the determination result is negative, the process proceeds to S45, but if the determination is affirmative, the process proceeds to S44. In S44, the received microscope image is displayed / updated.

  In S45, it is determined whether or not there has been a remote control of the microscope, that is, whether or not operation information has been input from the microscope remote control console 43. If the determination result is negative, the process proceeds to S47. To S46. In S46, microscope remote control information is transmitted to the PC 10.

  In S47, it is determined whether or not a position specifying operation has been performed, that is, whether or not a desired position of the displayed whole image has been clicked with the mouse. If the determination result is negative, the process proceeds to S51. If yes, the process proceeds to S48. In S48, position information at coordinates on the slide is calculated from the display position of the entire image on the display device and the mouse click position information.

  FIG. 10 is an explanatory diagram showing the relationship between the display image and the slide movement on the remote PC. The upper part of FIG. 10 is an example of a display screen in the remote PC 40, and an entire image is displayed on the left side and a microscope image is displayed on the right side. A soft button for performing an enlargement or movement operation by clicking with the mouse is displayed at the bottom of the screen.

  When a user such as a pathologist clicks a desired position on the entire image, the remote PC 40 calculates the distance between the click position and the outer frame origin. That is, if the origin position of the entire image on the screen is (x1, y1), the click position is (x2, y2), and the display magnification is m, the distance between the click position and the origin is ((x2-x1) / m, ( y2-y1) / m).

  Returning to FIG. 7, in S49, the movement control information of the electric XY stage is generated from the distance information described above and the origin position information of the slide on the XY stage calculated in S19 and recorded in the slide management server 30. That is, if the coordinate origin position of the preparation on the XY stage is (x3, y3), the click position in the coordinates of the XY stage is (x3 + (x2-x1) / m, y3 + (y2-y1) / m). Control information for moving the XY stage 27 so that this position coincides with the optical axis of the microscope is generated.

  In S50, the generated control information of the electric XY stage is transmitted to the PC 10. As a result, as shown in FIG. 10, the microscopic image at the clicked position is displayed on the remote PC 40. Therefore, the user can easily display an enlarged image by simply clicking a desired position and adjusting the focus, and can record the image by clicking the save button. In S51, it is determined whether or not an end instruction is input. If the determination result is negative, the process proceeds to S43, but if the determination is affirmative, the process ends.

  FIG. 8 is a flowchart showing the contents of processing in the preparation management server 30. In S60, it is determined whether or not an entire image registration request has been received from the PC 10. If the determination result is negative, the process proceeds to S62, but if the determination is affirmative, the process proceeds to S61. In S61, the received whole image is registered in the DB together with the preparation ID and the like.

  The DB 31 includes items such as a preparation ID, patient ID, whole image, outer frame position information in the whole image, preparation date and time, creator ID, comment, microscope image, microscope image coordinate information, microscope state information such as magnification and focus position, etc. It is configured so that information can be registered.

  In S62, it is determined whether or not it is an image read request from the remote PC 40 or the like. If the determination result is negative, the process proceeds to S64, but if the determination is affirmative, the process proceeds to S63. In S63, the entire image designated by the preparation ID or a previously stored microscope image is transmitted.

  In S64, it is determined whether or not a microscopic image storage request from the PC 10 has been received. If the determination result is negative, the process proceeds to S66, but if the determination is affirmative, the process proceeds to S65. In S65, the accompanying data such as the received microscope image and position information is registered in the DB 31 using the preparation ID as a key.

  In S66, it is determined whether or not a search request is received. If the determination result is negative, the process proceeds to S67, but if the determination is affirmative, the process proceeds to S68. In S67, the DB is searched using the patient ID or the like as a search key, and the result is output. The search by patient name or the like is processed in cooperation with the HIS 34.

  FIG. 9 is a flowchart showing the contents of the preparation search process (S15). This process is a process for taking out a preparation with a desired preparation ID from the storage shelf 14 in which a large number of preparations are stored. In S70, for example, a preparation ID to be searched is read from the keyboard.

  In S71, the portable RFID tag reader 13 is controlled to send a command so as to respond only to the tag of the preparation ID to be searched. Here, the user scans the preparation storage shelf 14 with the portable RFID tag reader 13. Then, only the RFID tag within a predetermined distance from the portable RFID tag reader 13 is supplied with power to receive and analyze the command. Only the ID tag specified by the command responds.

  In S72, it is determined whether or not there is a response from the tag. If the determination result is negative, the process proceeds to S71, but if the determination is affirmative, the process proceeds to S73. In S73, an LED lighting command is sent to the corresponding tag. The LED lighting command may be repeatedly sent at a predetermined cycle in which the LED can be turned on.

  In the tag, the LED 83 is turned on. In S74, the portable RFID tag reader 13 is controlled to display tag detection by lighting, sounding or the like. The user can easily take out the target preparation by displaying from the tag reader 13 and turning on the LED 83 of the preparation.

  Although the embodiments have been described above, the following modifications may be considered in the present invention. In the embodiment, an example in which a read-only tag is used has been disclosed. However, a writable nonvolatile memory such as a flash memory may be provided so that data such as a patient ID can be written from the outside.

As the tag display means, an example of using an LED or an EL has been disclosed. However, for example, a display device that only changes color without emitting light, such as a liquid crystal display or an electronic paper element, may be used. They can be driven with very low power.
The outer frame line may be a square frame, but may be a figure such as a + character arranged only at the four corners or the upper left corner.

  In the embodiment, an example in which the PC 10, the remote PC 40, and the management server 30 are separate devices is disclosed, but for example, either the PC 10 or the remote PC 40 may have the functions of the management server 30 and the DB 31.

It is a block diagram which shows the hardware constitutions of the whole system containing the apparatus of this invention. It is the top view and sectional drawing which show the structure of the preparation 50 of this invention. It is sectional drawing which shows the structure of the other Example of the preparation 50 of this invention. It is a block diagram of the preparation provided with the RFID tag function of the present invention. It is a block diagram of the other Example of the preparation provided with the RFID tag function of this invention. It is a flowchart which shows the content of the process in PC10. It is a flowchart which shows the content of the process in remote PC40. 4 is a flowchart showing the contents of processing in a preparation management server 30. It is a flowchart which shows the content of a preparation search process (S15). It is explanatory drawing which shows the relationship between the display image in a remote PC, and the movement of a preparation.

Explanation of symbols

10 ... PC
DESCRIPTION OF SYMBOLS 11 ... Display and input device 12 ... Magnetic card reader 13 ... Portable RFID tag reader 14 ... Preparation slide storage 20 ... Digital camera 21 ... Tag reader 25 ... Microscope 26 ... Microscope camera 27 ... Electric XY stage 30 ... Preparation management server 31 ... Database (DB) )
32 ... LAN
33 ... Router 34 ... Hospital information system 35 ... Internet 40 ... Remote PC
41 ... Display device 42 ... Keyboard, mouse 43 ... Microscope remote control console

Claims (8)

RFID tag means for transmitting unique ID information stored in response to an external read command;
A preparation comprising: a positioning outer frame means displayed on at least a part of a periphery of an area on which a sample is placed.   2. The preparation according to claim 1, further comprising display means for emitting or changing color in response to an external display command. The preparation according to claim 1, wherein the plastic plate includes the RFID tag unit and the outer frame unit, and further has a structure in which a plastic plate having an opening on which a sample is placed is bonded to a glass plate. . RFID tag reading means for reading ID information from the preparation;
Digital camera means for taking a whole image of the preparation sample;
Microscope means that can be controlled from the outside and can be photographed by a mounted microscope camera,
Electric stage means connected to the microscope means and capable of moving the preparation in a desired direction;
A preparation management apparatus comprising: the RFID tag reading means; the digital camera means; the microscope means; and a computer means for controlling the electric stage means.   And a second computer means connected to the computer means via the communication means, displaying a microscope image sent from the computer means, and transmitting control information of the microscope means to the computer means. The preparation management apparatus according to claim 4, wherein   6. The preparation management apparatus according to claim 5, further comprising server means for storing an entire image of the preparation photographed by the digital camera means and transmitting it to the second computer means in response to a request. . The computer means controls the microscope means based on the control information received from the second computer means, and has a function of periodically taking an image from the microscope camera and transmitting it to the second computer means,
The second computer means has a function of displaying a whole image acquired from the server means and generating control information of the microscope means based on a click position on the image. The prepared preparation management device. Reading out and displaying the entire image of the stored preparation;
Obtaining position information of the clicked part on the whole image;
A step of calculating control information of the electric stage for matching the position where the optical axis of the microscope on which the preparation is set is clicked based on the position information;
Moving the motorized stage so that the optical axis of the microscope matches the clicked position;
The preparation management method characterized by including the step which displays a microscope image.

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