JP2007170973A - Dispenser, analyzer and discharge chip - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a dispenser for accurately grasping an actually discharged amount at every discharge nozzle, an analyzer and a discharge chip. <P>SOLUTION: The dispenser has a discharge nozzle 142 for holding a predetermined amount of a liquid and determining the discharge amount of the liquid discharged outside, the discharge port 143 connected to the discharge nozzle 142 to work as a flow channel at the time of discharge of the liquid outside, a pressure mechanism 12 for applying the pressure for discharging the liquid outside from the discharge port 143 to the liquid and an IC tag 15 for holding the data related to the discharge amount of the liquid discharged outside. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a dispensing device, an analyzer, and a discharge chip for dispensing a minute amount of a desired liquid.

  Conventionally, in order to perform an analysis on a living body, a sample of a minute amount of nL to μL is discharged, a reagent is dispensed to the discharged sample, and the absorbance of a mixed solution of the sample and the reagent is measured. An analyzer for analyzing a sample is known. In general, an analyzer includes a dispensing device that discharges a liquid as a sample. As a configuration of the dispensing apparatus, Patent Document 1 and Patent Document 2 include a dispensing tip having a discharge nozzle for discharging a liquid, and applies a predetermined amount of liquid by applying pressure to the liquid held by the discharge nozzle. A technique for discharging is disclosed.

Special Table 2000-500567 German Patent Invention No. 10102152

  By the way, the amount of liquid ejected using the chip depends on the volume of the ejection nozzle. In general, the discharge tip is formed by injection molding using a mold, but the volume of the discharge nozzle may vary depending on the processing accuracy of the mold itself or various conditions of the processing steps. For this reason, since the amount of liquid actually discharged from the discharge nozzle differs from the designed amount, it has been difficult to accurately grasp the amount actually discharged.

  The present invention has been made in view of the above, and an object thereof is to provide a dispensing device, an analyzer, and a discharge chip that can accurately grasp the amount actually discharged for each discharge nozzle.

  In order to achieve the above object, a dispensing apparatus according to claim 1 is connected to a discharge nozzle that holds a predetermined amount of liquid and determines a discharge amount for discharging the liquid to the outside, and the discharge nozzle. A discharge port serving as a flow path when discharging the liquid to the outside; a pressurizing mechanism that applies pressure to the liquid to discharge the liquid from the discharge port to the outside; and discharging the liquid discharged to the outside And an information storage unit that holds information about the quantity.

  The dispensing apparatus according to claim 2 is characterized in that, in the above-described invention, the discharge amount determined by the discharge nozzle is determined based on a volume of the discharge nozzle.

  According to a third aspect of the present invention, in the above invention, the dispensing apparatus has a plurality of the discharge nozzles.

  According to a fourth aspect of the present invention, in the above-described dispensing device, the information storage unit holds information regarding the discharge amount for each of the plurality of discharge nozzles.

  According to a fifth aspect of the present invention, in the above-described dispensing device, the information relating to the discharge amount held by the information storage unit is information corresponding to individual differences of the discharge nozzles.

  The dispensing apparatus according to claim 6 is characterized in that, in the above invention, the information corresponding to the individual difference is information on variation in volume of the discharge nozzle.

  According to a seventh aspect of the present invention, in the above-described invention, the information on the variation in the volume of the discharge nozzle is an effective dispensing amount that is the amount of the liquid discharged to the outside. .

  Further, in the dispensing device according to claim 8, in the above invention, the information on the variation in the volume of the discharge nozzle is a manufacturing lot of the discharge nozzle or a die number used when manufacturing the discharge nozzle. It is characterized by corresponding.

  The dispensing apparatus according to claim 9 is characterized in that, in the above invention, the information storage unit includes an IC tag, an optically readable code, or a character or symbol visible to the naked eye. .

  The dispensing apparatus according to claim 10 further includes a reservoir connected to the discharge nozzle and holding the liquid in the invention, and the liquid held in the reservoir utilizes capillary force. And introduced into the discharge nozzle.

  The dispensing apparatus according to claim 11 is characterized in that, in the above invention, the liquid is a biological sample.

  According to a twelfth aspect of the present invention, there is provided the analyzer according to the above invention, wherein the analyzer is configured to hold a predetermined amount of liquid and determine a discharge amount for discharging the liquid to the outside; A discharge port serving as a flow path when discharging liquid to the outside, a pressurizing mechanism for applying pressure to the liquid to discharge the liquid from the discharge port to the outside, and a discharge amount of the liquid discharged to the outside An information storage unit that holds information; a reading unit that reads information about the discharge amount held in the information storage unit; and an information processing unit that processes information about the discharge amount read by the reading unit. It is characterized by.

  The analyzing apparatus according to a thirteenth aspect of the present invention is characterized in that, in the above-described invention, the analyzer further includes a correcting unit that performs correction according to information on the ejection amount.

  According to a fourteenth aspect of the present invention, in the above invention, the correction means has information for correction associated with information related to the discharge amount.

  The analyzing apparatus according to claim 15 is characterized in that, in the above invention, the correction means adjusts the amount of the reagent added to the liquid after being discharged to the outside.

  According to a sixteenth aspect of the present invention, in the above invention, the correction means corrects the analysis data of the liquid after being discharged to the outside.

  According to a seventeenth aspect of the present invention, there is provided a discharge chip according to the above invention, wherein the discharge chip holds a predetermined amount of liquid, determines a discharge amount for discharging the liquid to the outside, and is connected to the discharge nozzle and the liquid. A discharge port serving as a flow path when discharging the liquid to the outside, and an information storage unit for holding information on the discharge amount of the liquid discharged from the discharge port to the outside by applying pressure to the liquid. It is characterized by having.

  In the dispensing device, the analyzer, and the discharge chip according to the present invention, the actual discharge amount actually discharged by the discharge nozzle of the discharge chip is stored in a storage medium such as an IC tag. There is an effect that can be accurately grasped.

  Exemplary embodiments of a dispensing device, an analyzer, and a discharge chip according to the present invention will be explained below in detail with reference to the accompanying drawings.

(Embodiment 1)
FIG. 1 is a block diagram showing a schematic configuration of an analyzer 1 according to the first embodiment of the present invention. As shown in FIG. 1, the analyzer 1 discharges a very small amount of a sample to be analyzed, dispenses a reagent to the discharged sample, and performs an absorbance measurement on a mixed solution of the sample and the reagent. A table 2 and a control unit 3 that controls the work performed by the work table 2 and calculates the absorbance of the specimen. Here, the specimen refers to a biological sample that is a body fluid such as blood, blood extract components, saliva, lymph, or a liquid extracted from them, and the reagent is a liquid that reacts with or dilutes the specimen. It is.

  The work table 2 includes a dispensing mechanism 16 that dispenses a sample to the discharge tip 14, a discharge tip 14 that discharges the sample to the cuvette 11, and a dispensing mechanism 6 that dispenses a reagent to the cuvette 11 from which the sample has been discharged. Have As shown in FIG. 3, the discharge chip 14 includes a reservoir 140 that stores a specimen, a discharge nozzle 142 that discharges the specimen, and a flow path 141 that connects the reservoir 140 and the discharge nozzle 142.

  Furthermore, the work table 2 includes a sample container 19 that stores a sample that is a liquid such as blood and urine, a sample rack 18 that holds the sample container 19, a dispensing arm 160 attached to the dispensing mechanism 16, and a dispensing. The cleaning unit 17 that cleans the nozzles of the arm 160, removes the previous specimen history, and the discharge tip 14 are fixed and rotated, and the position at which the specimen is dispensed to the discharge tip 14 and the discharge tip 14 are placed in the cuvette 11. A pedestal 20 that stops at a position where the sample is discharged and a pressure mechanism 12 that pressurizes the discharge tip 14 and discharges the sample to the cuvette 11 are provided. Embedded in the discharge chip 14 is an IC tag 15 that is a storage medium for storing discharge nozzle information, which is information relating to the amount of the sample discharged by the discharge chip 14. Further, the work table 2 holds and rotates the reader 13 for reading information stored in the IC tag 15 and the cuvette 11, and the cuvette 11 is rotated by the sample discharge position, the reagent dispensing position, and the mixed liquid of the sample and the reagent. A holder 10 that is stopped at each absorbance measurement position, a cool box 4 that holds a reagent container 5, a light source unit 8 that irradiates light to a mixed liquid in which a specimen and a reagent are mixed, and a cuvette. And a light receiving unit 9 that receives the transmitted light that has passed through 11.

  The control unit 3 includes a reading information processing unit 30 that performs input processing on the discharge nozzle information read by the reader 13, and a reagent that is dispensed to the specimen to make corrections based on the discharge nozzle information input by the reading information processing unit 30. A reagent dispensing amount calculation unit 31 for calculating the amount of light, an absorbance calculation unit 32 for calculating absorbance based on the light intensity received by the light receiving unit 9 of the work table 2, and reader drive control for controlling the drive of the reader 13 Part 33.

  Here, the discharge operation of the discharge chip 14 will be described. FIG. 2 is a plan view showing the discharge tip 14 fixed to the pedestal 20. As shown in FIG. 2, the four discharge chips 14 are fixed to the base 20 by two bolts 143a and 143b, respectively. The corner on one side of the discharge tip 14 is scraped off, and the pedestal 20 has a protrusion at a position corresponding to this one side to prevent the discharge tip 14 from being attached upside down. Of course, the corners do not necessarily have to be removed. The pedestal 20 stops at a position where the dispensing arm 160 dispenses the sample to the discharge tip 14, and the dispensing arm 160 aspirates the sample from the sample container 19 and dispenses a predetermined amount of sample to the discharge tip 14. To do. Thereafter, the pedestal 20 rotates 1/4 in the counterclockwise direction, and stops at a position where the discharge tip 14 discharges a predetermined minute amount of sample to the cuvette 11.

  When the discharge tip 14 stops at a position where a small amount of specimen is discharged, the pressurizing mechanism 12 is lowered and attached to the discharge tip 14. The pressurizing mechanism 12 pressurizes the liquid held by the ejection tip 14 and ejects the specimen from the ejection tip 14 to the cuvette 11. Thereafter, the reader 13 is driven under the control of the reader drive control unit 33 and reads the ejection nozzle information stored in the IC tag 15.

  FIG. 3 is a perspective view showing details of the discharge tip 14 and a state in which the discharge tip 14 is fixed to the base 20. The discharge chip 14 has three discharge nozzles 142 and an IC tag 15 is embedded on the side surface of each discharge chip 14. The IC tag 15 stores discharge nozzle information of each discharge nozzle 142 included in the discharge chip 14. As the discharge nozzle information, information corresponding to individual differences of the discharge nozzles 142 is stored. The information corresponding to the individual difference is information on the variation in volume for each discharge nozzle 142. For example, as shown in FIG. “Manufacturing mold No” indicating the mold used for manufacturing, “Manufacturing lot No” indicating the manufacturing lot, “Notation discharge amount” which is the design capacity of the discharge nozzle 142, and actual measurement using liquid The “substantially discharged amount” is stored. Of course, the information stored in the IC tag 15 need not necessarily include all of the above, and may be any one. The discharge tip 14 is fixed to the pedestal 20 by two bolts 143a and 143b so as not to be positioned.

  Since the discharge nozzles 142 are arranged to match the arrangement of the cuvettes 11, the three discharge nozzles 142 correspond to the three cuvettes 11 at the same time (can be arranged on the three cuvettes at the same time).

  FIG. 4 is a cross-sectional view showing the discharge tip 14 to which the pressurizing mechanism 12 is attached. As shown in FIG. 4, the pressurizing mechanism 12 includes a gas introduction pipe 120 that introduces pressurized gas to the discharge tip 14, an on-off valve 121 that controls the timing of gas introduction, and a pressurization introduced into the discharge tip 14. It has the filter 122 which applies a gas equally, and the O-ring 123 which adhere | attaches the discharge tip 14. FIG. On the other hand, the discharge chip 14 discharges the specimen held by the discharge nozzle 142 from the discharge port 143 when the pressurized gas is introduced in pulses by the opening / closing valve 121 of the pressurization mechanism 12. Even without the filter 122, the liquid can be discharged.

  FIG. 5 is a perspective view showing the detailed appearance of the ejection tip 14. As shown in FIG. 5, the reservoir 140, the flow path 141, the discharge nozzle 142, and the discharge port 143 are integrated. When the sample filled in the discharge nozzle 142 is pressurized and discharged from the discharge port 143 and the discharge nozzle 142 becomes empty, the sample is supplied from the reservoir 140 to the discharge nozzle 142 via the flow path 141 by capillary action and discharged. The nozzle 142 is again filled with the specimen. That is, the discharge chip 14 discharges a sample corresponding to the volume of the discharge nozzle 142 and always discharges a predetermined amount of sample.

  FIG. 6 is a flowchart showing the operation procedure of the dispensing process of the analyzer 1. First, the control unit 3 determines whether or not the ejection tip 14 is at the specimen ejection position (step S101). When the discharge tip 14 is at the discharge position (step S101, Yes), the sample is discharged to the cuvette 11 (step 102). Thereafter, the reader drive control unit 33 drives the reader 13 and reads the stored contents of the IC tag 15 (step S103). The reader 13 sends the read ejection nozzle information to the reading information processing unit 30. The reading information processing unit 30 inputs the indicated discharge amount, which is a design amount of the discharge nozzle 142, and the actual discharge amount actually measured using the liquid from the discharge nozzle information. Then, the read information processing unit 30 determines whether or not the actual discharge amount L of the discharge nozzle 142 that has discharged is within a predetermined allowable range (L0 ≦ L ≦ L1) with respect to the discharge amount required this time. (Step S104). When the actual discharge amount L is within the allowable range (step S104, Yes), the control unit 3 controls the dispensing mechanism 6 to dispense a predetermined amount of reagent to the cuvette 11 (step S105). On the other hand, when the actual discharge amount L is not within the allowable range (L0 ≦ L ≦ L1) (No at Step S104), the reagent dispensing amount calculation unit 31 has the liquid volume ratio between the sample and the reagent within the allowable range. The amount of reagent dispensed is calculated (step S106). Thereafter, the control unit 3 drives and controls the dispensing mechanism 6, and dispenses the reagent whose amount has been adjusted by the reagent dispensing amount computing unit 31 with respect to the cuvette 11 from which the specimen has been discharged (step). S107). Note that the order of step S102 and step S103 can be interchanged. Moreover, you may go simultaneously.

  FIG. 8 is a schematic diagram showing that the analyzer 1 can measure absorbance with a liquid mixture having a desired liquid volume ratio. For example, it is assumed that 30 nL of sample is discharged and a mixed liquid with a liquid volume ratio of 1.0% with respect to 3 μL of reagent is measured, and the actual discharge volume of the discharge nozzle 142 is 27 nL. The read information processing unit 30 detects that the discharge nozzle 142 has discharged a 27 nL sample through the IC tag 15 and determines that 27 nL is outside the allowable range. Therefore, the reagent dispensing amount calculation unit 31 calculates a reagent dispensing amount of 2.7 μL to make the liquid ratio 1.0%. The control unit 3 controls the dispensing mechanism 6 to dispense 2.7 μL of reagent to the cuvette 11 from which 27 nL of sample has been discharged. As a result, the liquid volume ratio of the sample with respect to the reagent of the cuvette 11 becomes 1.0%, and the absorbance can be measured for the mixed liquid having a desired liquid volume ratio of 1.0%. That is, the control unit 3 detects the amount of sample actually discharged by the discharge nozzle 142, calculates the amount of reagent to be added, and dispenses the calculated reagent, thereby creating a mixed liquid having a desired liquid volume ratio. it can. Since the required amount of the reagent is larger than that of the sample, the adjustment of the reagent amount is easier than the adjustment of the sample amount.

  In the first embodiment, since the IC tag 15 storing the substantial discharge amount is attached to the discharge chip 14, even if the discharge chip 14 actually discharges, the discharge chip 14 is different from the manufacturing design value. However, it is possible to accurately grasp the amount actually discharged from the discharge tip 14. Further, when the specimen is ejected from the ejection tip 14, the reader 13 reads the IC tag 15 storing the actual ejection amount actually ejected by the ejection nozzle 142, and calculates the reagent amount to be dispensed based on this actual ejection amount. Therefore, the absorbance of the mixed liquid having a desired liquid volume ratio can be measured, and high-precision analysis can be performed.

  In the first embodiment, the IC tag 15 is disposed on the side surface of the ejection chip 14, but may be disposed on a location other than the side surface. Moreover, although the discharge tip 14 has the three discharge nozzles 142, it is not limited to three.

  Further, the IC tag 15 stores the discharge nozzle information, but instead of the IC tag 15, an optically readable code or a magnetic tape or the like stores the discharge nozzle information. It may be replaced with a typical reader or a magnetic head. Further, “characters”, “symbols” and the like that are visible to the naked eye as a storage medium may be printed on the ejection chip 14 and projected by a CCD camera or the like so that they can be seen. In the first embodiment, the reagent is dispensed into the cuvette 11 after dispensing the sample into the cuvette 11. However, it is also possible to dispense the specimen into the cuvette 11 after dispensing the reagent. In this case, the discharge nozzle information is read in advance from the IC tag, the reagent amount calculated from the information is dispensed to the cuvette 11, and then the sample is dispensed to the cuvette 11.

(Embodiment 2)
Next, a second embodiment of the present invention will be described. In the first embodiment, the reagent corresponding to the discharge amount is dispensed after the specimen is ejected first. However, in this second embodiment, the specimen is ejected after the reagent is dispensed first, and the measurement result. I am trying to correct.

  FIG. 9 is a block diagram showing a schematic configuration of the analyzer 1A according to the second embodiment. As shown in FIG. 9, the analysis apparatus 1A replaces the control unit 3 shown in the first embodiment with a control unit 3A. The control unit 3A replaces the reagent dispensing amount calculation unit 31 with the correction unit 34, and the correction unit 34 includes a table 340. The table 340 describes correction information associated with the discharge nozzle information. Other configurations are the same as those of the first embodiment, and the same reference numerals are given to the same components.

  In the analyzer 1A, the holder 10 moves counterclockwise as viewed from above, and after the dispensing mechanism 6 dispenses a predetermined amount of reagent into the cuvette 11, the discharge tip 14 discharges the sample into the cuvette 11. I am doing so. When the sample is dispensed first and the sample whose amount is adjusted is discharged later, it is difficult to adjust because the amount of sample discharged is very small, and it is possible to measure the absorbance using a mixture of the desired liquid volume ratio. difficult.

  Therefore, once the absorbance measurement is performed on the liquid mixture that does not have a predetermined liquid volume ratio, the control unit 3A determines that the measurement result is a predetermined value based on the actual discharge amount detected via the reader 13. Correction is performed so that the measurement result obtained at the liquid volume ratio is obtained.

  FIG. 10 is a flowchart showing a series of operations of the analyzer 1A. As shown in FIG. 10, first, the dispensing mechanism 6 dispenses a predetermined amount of reagent into the cuvette 11 (step S201). Thereafter, the control unit 3A determines whether or not the discharge tip 14 is at the discharge position (step S202). If the discharge tip 14 is at the discharge position (step S202, Yes), the sample is placed in the cuvette 11. The ejection nozzle information stored in the IC tag 15 is read (step S204). Thereafter, the absorbance of the mixed solution of the reagent and the sample is measured, and the absorbance is calculated (step S205). The reading processing unit 30 inputs the actual discharge amount L via the reader 13, and determines whether or not the actual discharge amount L is within an allowable range (L0 ≦ L ≦ L1) (step S206). When the actual discharge amount L is within the allowable range (L0 ≦ L ≦ L1) (step S206, Yes), the control unit 3A directly uses the calculation result calculated by the absorbance calculation unit 32 as the absorbance result. On the other hand, when the actual discharge amount L is not within the allowable range (L0 ≦ L ≦ L1) (No at Step S206), the correction unit 34 calculates a correction coefficient corresponding to the actual discharge amount L described in the table 340. The result is multiplied to correct the measurement result (step S207).

  FIG. 11 is an example of the contents described in this table 340. As shown in FIG. 11, the liquid amount ratio and the correction coefficient are described together with the actual discharge amount with respect to the indicated discharge amount. In addition, this example shows the content of the written discharge amount 30 nL, but it can cope with different written discharge amounts.

  FIG. 12 shows that the analyzer 1A matches the measurement result obtained at the desired liquid volume ratio by correcting the measurement result even when the mixed liquid of the reagent and the sample is not at the desired liquid volume ratio. It is a schematic diagram which shows that it can be performed. As shown in FIG. 12, for example, when the desired liquid volume ratio between the reagent and the sample is 1.0%, after dispensing 3 μL of the reagent, a sample with a written discharge amount of 30 nL and a substantial discharge amount of 27 nL is obtained. Suppose that it was discharged. In this case, the liquid volume ratio between the reagent and the sample is 0.9%. The absorbance calculation unit 32 calculates the absorbance of the liquid mixture having a liquid volume ratio of 0.9%. When the sample discharge amount 27 nL is outside the allowable range, the correction unit 34 reads the correction coefficient 1.3 corresponding to the actual discharge amount 27 nL and the liquid volume ratio 0.9% from the table 340, and outputs 1. Multiply by 3. As a result, even when the measurement is performed with respect to the liquid volume ratio of 0.9% between the reagent and the specimen, the measurement can be made to coincide with the measurement result with respect to the liquid volume ratio of 1.0%.

  In the second embodiment, an accurate analysis result can be acquired by correcting the analysis result even when the reagent is dispensed first and then the specimen is discharged. In the second embodiment, the correction unit 34 has the table 340. However, a correction coefficient may be calculated each time correction is performed. In addition, the correction unit 34 multiplies the analysis result by the correction coefficient, but the calculation result may be corrected using other methods.

  In the first embodiment described above, by detecting the discharge amount actually discharged by the discharge nozzle 142, a mixed liquid having a desired liquid amount ratio can be created, and high-precision analysis can be performed. Moreover, the same analysis result as the absorbance measurement performed on the mixed liquid having a desired liquid volume ratio can also be obtained by correcting the analysis result as in the second embodiment.

  In the first embodiment, the control unit 3 has the reagent dispensing amount calculation unit 31, and in the second embodiment, the control unit 3A has the correction unit 34. You may make it have both the reagent dispensing amount calculating part 31 and the correction | amendment part 34 so that it can do.

It is a block diagram which shows schematic structure of the analyzer concerning Embodiment 1 of this invention. It is a top view which shows the upper surface of the base and discharge tip concerning Embodiment 1 of this invention. It is a perspective view which shows the attachment condition of the discharge tip concerning Embodiment 1 of this invention. It is sectional drawing which shows the cross section of the pressurization mechanism concerning Embodiment 1 of this invention. It is a perspective view which shows the detail of the discharge tip concerning Embodiment 1 of this invention. It is a flowchart which shows the dispensing operation | movement of the analyzer concerning Embodiment 1 of this invention. It is a schematic diagram which shows the content which the IC tag concerning Embodiment 1 of this invention memorize | stores. It is a schematic diagram which shows operation | movement of the analyzer concerning Embodiment 1 of this invention. It is a block diagram which shows schematic structure of the analyzer concerning Embodiment 2 of this invention. It is a flowchart which shows dispensing operation | movement of the analyzer concerning Embodiment 2 of this invention. It is a schematic diagram which shows the content of the table concerning Embodiment 2 of this invention. It is a schematic diagram which shows operation | movement of the analyzer concerning Embodiment 2 of this invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1,1A Analyzer 2 Work table 3,3A Control part 4 Cold storage 5 Reagent container 6,16 Dispensing mechanism 7,160 Dispensing arm 8 Light source part 9 Light receiving part 10 Holder 11 Cuvette 12 Pressurization mechanism 13 Reader 14 Discharge tip DESCRIPTION OF SYMBOLS 15 IC tag 17 Washing part 18 Sample rack 19 Sample container 20 Base 30 Reading information processing part 31 Reagent dispensing amount calculation part 32 Absorbance calculation part 33 Reader drive part 34 Correction part 140 Reservoir 141 Flow path 142 Discharge nozzle 143 Discharge port 340 Table

Claims (17)

A discharge nozzle for holding a predetermined amount of liquid and determining a discharge amount for discharging the liquid to the outside;
A discharge port connected to the discharge nozzle and serving as a flow path when discharging the liquid to the outside;
A pressurizing mechanism for applying a pressure to the liquid to discharge the liquid to the outside from the discharge port;
An information storage unit for holding information on the discharge amount of the liquid discharged to the outside;
A dispensing device characterized by comprising:   The dispensing apparatus according to claim 1, wherein the discharge amount determined by the discharge nozzle is determined based on a volume of the discharge nozzle.   The dispensing apparatus according to claim 1, comprising a plurality of the discharge nozzles.   The dispensing apparatus according to claim 3, wherein the information storage unit holds information regarding the discharge amount for each of the plurality of discharge nozzles.   The dispensing apparatus according to claim 1, wherein the information related to the discharge amount held by the information storage unit is information corresponding to individual differences of the discharge nozzles.   6. The dispensing apparatus according to claim 5, wherein the information corresponding to the individual difference is information on variation in volume of the discharge nozzle.   The dispensing apparatus according to claim 6, wherein the information on the variation in volume of the discharge nozzle is an effective dispensing amount that is an amount of the liquid discharged to the outside.   7. The dispensing apparatus according to claim 6, wherein the information on the variation in volume of the discharge nozzle corresponds to a manufacturing lot of the discharge nozzle or a die number used when manufacturing the discharge nozzle.   The dispensing apparatus according to claim 1, wherein the information storage unit includes an IC tag, an optically readable code, or characters or symbols that are visible to the naked eye. A reservoir connected to the discharge nozzle and holding the liquid;
The dispensing apparatus according to claim 1, wherein the liquid held in the reservoir is introduced into the discharge nozzle using a capillary force.   The dispensing apparatus according to claim 1, wherein the liquid is a biological sample. A discharge nozzle for holding a predetermined amount of liquid and determining a discharge amount for discharging the liquid to the outside;
A discharge port connected to the discharge nozzle and serving as a flow path when discharging the liquid to the outside;
A pressurizing mechanism for applying a pressure to the liquid to discharge the liquid to the outside from the discharge port;
An information storage unit for holding information on the discharge amount of the liquid discharged to the outside;
A reading unit for reading information on the ejection amount held in the information storage unit;
An information processing unit for processing information relating to the ejection amount read by the reading unit;
An analysis apparatus comprising:   The analysis apparatus according to claim 12, further comprising a correction unit that performs correction according to information on the ejection amount.   The analysis apparatus according to claim 13, wherein the correction unit includes information for correction associated with information related to the ejection amount.   The analyzer according to claim 13, wherein the correction unit adjusts an amount of a reagent added to the liquid after being discharged to the outside.   The analyzer according to claim 13, wherein the correction unit corrects analysis data of the liquid after being discharged to the outside. A discharge nozzle for holding a predetermined amount of liquid and determining a discharge amount for discharging the liquid to the outside;
A discharge port connected to the discharge nozzle and serving as a flow path when discharging the liquid to the outside;
An information storage unit for holding information on the discharge amount of the liquid discharged from the discharge port to the outside when pressure is applied to the liquid;
Discharge tip characterized by having.

Images