JP2007015963A - Patch - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a patch capable of readily making cost low and sufficiently preventing release of keratin when releasing from the skin while ensuring sufficient adhesive force between an adhesive layer and a support. <P>SOLUTION: The patch has a support and an adhesive layer provided on the support. The adhesive layer contains a base having adhesiveness, an oil and a medicine, and the base is composed of an adhesive composition composed of at least an elastomer and an adhesiveness-imparting agent and/or an adhesive polymer containing an unsaturated monomer having ≥5 total carbon numbers as a monomer unit and the oil is compatible with the adhesive composition and the adhesive polymer and the content of the oil is 60-200 pts.mass based on 100 pts.mass total of the adhesive composition and the adhesive polymer and the support is a nonwoven fabric or a woven fabric containing an antistatic agent. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a patch, and more particularly to a patch comprising at least an adhesive layer and a support containing an antistatic agent.

  Usually, the patch has a manufacturing process in which an adhesive paste is directly applied to a support made of a nonwoven fabric or a woven fabric, or the paste is spread by applying the paste to a release film and transferring it to the support. It is manufactured after.

  In the method for producing a patch having the steps as described above, if a support made of a normal nonwoven fabric or woven fabric is used, static electricity accumulates on the support during production, and the cause of wrinkling and twisting on the support is caused. It was. In order to manufacture while avoiding this, there is a problem that the manufacturing efficiency becomes extremely low. Of course, it is conceivable to install a device that discharges static electricity during the manufacturing process and remove the static electricity, but there is a problem that the capital investment is expensive and the static electricity cannot be completely removed.

  On the other hand, the manufactured patch is put on the market as a product and is applied to an affected part of a patient. As a characteristic of the patch used in this manner, the support does not peel from the pressure-sensitive adhesive layer, that is, a high anchoring property between the support and the pressure-sensitive adhesive layer is required. This is because when the support is peeled from the pressure-sensitive adhesive layer, the pressure-sensitive adhesive layer is left behind on the skin.

  In this way, anchorage with sufficient adhesive force is required between the support and the adhesive layer, whereas when the adhesive force between the adhesive layer and the skin is excessively strong. After the application time of the patch, the stratum corneum is peeled off when the patch is peeled from the skin, which may cause skin irritation or skin irritation.

In order to control the adhesive force between the pressure-sensitive adhesive layer and the skin, for example, Patent Documents 1 and 2 disclose that liquid polyisoprene and / or a block copolymer containing polyisoprene is a main component of the base of the pressure-sensitive adhesive layer. A patch has been proposed.
JP-A-61-151121 Japanese Patent Laid-Open No. 3-86828

  However, even in the case of a patch comprising a liquid polyisoprene and / or a block copolymer containing polyisoprene as a base component of the adhesive layer, the adhesive force between the adhesive layer and the skin, In addition, it is difficult to control the adhesive force between the support and the adhesive layer to an appropriate level. Moreover, in the support body used for the patch described in Patent Documents 1 and 2, static electricity cannot be prevented from accumulating during production, production efficiency cannot be sufficiently increased, and cost reduction is difficult. there were.

  Therefore, an object of the present invention is to provide a patch that can be easily reduced in cost and can sufficiently prevent keratin exfoliation when peeling from the skin while ensuring sufficient adhesive force between the adhesive layer and the support. Is to provide.

  As a result of intensive studies to achieve the above object, the present inventors have included an adhesive base and an oil compatible with the base in a predetermined ratio in the adhesive layer, and an antistatic agent. It has been found that the above-mentioned object can be achieved by spreading the pressure-sensitive adhesive layer on a support containing bismuth to form a patch, and the present invention has been completed.

  That is, the present invention provides a patch comprising a support and a pressure-sensitive adhesive layer formed on the support, wherein the pressure-sensitive adhesive layer contains an adhesive base, oil, and drug, and the base Is composed of at least an adhesive composition comprising an elastomer and a tackifier, and / or an adhesive polymer containing an unsaturated monomer having a total carbon number of 5 or more as a monomer unit, and the oil is the adhesive composition The oil content is 60 to 200 parts by mass with respect to a total of 100 parts by mass of the adhesive composition and the adhesive polymer. The support is a nonwoven fabric or a woven fabric containing an antistatic agent.

  In general, the adhesive base contained in the pressure-sensitive adhesive layer tends to be negatively charged, and the support made of woven or non-woven fabric also tends to be negatively charged. However, according to the patch of the present invention, it has been confirmed that the anchoring property between the support and the adhesive layer is sufficiently improved. The reason is not clear, but in the patch of the present invention, the pressure-sensitive adhesive layer can be obtained by increasing the mass ratio of oil to the total of the pressure-sensitive adhesive composition and the pressure-sensitive adhesive polymer in the pressure-sensitive adhesive layer. While the amount of the base in the substrate is relatively reduced, the charging of the support is suppressed by introducing an antistatic agent into the support. As a result, the anchoring property due to the charging of the adhesive layer and the charging of the support is reduced. This may be because the impact on the decline is suppressed.

In the pressure-sensitive adhesive layer, the mass ratio of the oil to the total of the pressure-sensitive adhesive composition and the pressure-sensitive polymer is larger than that of a general patch, so that the pressure-sensitive adhesive force between the pressure-sensitive adhesive layer and the skin is moderate. Can be a thing. For this reason, even if it peels after sticking the patch of this invention to a patient, keratin peeling is fully prevented and the pain at the time of peeling is also reduced.
Furthermore, since the pressure-sensitive adhesive layer contains a large amount of oil, the pressure-sensitive adhesive layer is appropriately softened and the adhesion to the skin is improved. For this reason, sufficiently high transdermal absorbability of the drug contained in the pressure-sensitive adhesive layer can be obtained.
Furthermore, in the patch of the present invention, since the antistatic agent is contained in the support, the support has an antistatic function. Therefore, when producing the patch of the present invention, charging of the woven fabric or nonwoven fabric constituting the support is sufficiently prevented, and generation of wrinkles and twists is sufficiently prevented, so that production efficiency is improved. As a result, cost reduction of the patch becomes easy.

  In the patch of the present invention, it is preferable that a part of the pressure-sensitive adhesive layer penetrates into the support. In this case, the anchoring property between the support and the pressure-sensitive adhesive layer can be further improved.

  In addition, the support of the patch of the present invention contains an antistatic agent, which can prevent static electricity from accumulating during production, and can suppress the generation of wrinkles and kinks caused by static electricity. Can be high enough. For this reason, cost reduction of the patch becomes easy.

  As the elastomer constituting the adhesive composition, a styrene-based block copolymer is suitable, and in particular, a styrene-isoprene-styrene block copolymer having a styrene content of 10 to 30% by mass and a diblock body content of 40% by mass or less. Is preferred.

  When such a styrenic block copolymer is used as an elastomer constituting the adhesive composition, there are more remarkable improvements in all of the adhesion to the skin, prevention of exfoliation of the skin, and anchorage of the support and the adhesive layer. It will come to be able to plan.

  As an adhesive polymer containing an unsaturated monomer having a total carbon number of 5 or more as a monomer unit, an adhesive polymer containing an alkyl (meth) acrylate having an alkyl group having 4 to 22 carbon atoms as a monomer unit is suitable. Here, (meth) acrylate means acrylate or methacrylate.

  The oil compatible with the adhesive composition and the adhesive polymer is preferably liquid paraffin. When liquid paraffin is used, the adhesion to the skin and the effect of preventing rash at the time of sticking become excellent.

  As the antistatic agent, at least one selected from the group consisting of a nonionic surfactant, an anionic surfactant, a cationic surfactant and an amphoteric surfactant is suitable.

  Moreover, what consists of polyester, polyethylene, or a polypropylene can be used as a nonwoven fabric or a woven fabric. In addition, since polyester, polyethylene, and polypropylene have a property of being easily negatively charged, an anionic surfactant is particularly suitable as an antistatic agent when using a nonwoven fabric or woven fabric made of these fibers. Yes.

  According to the present invention, there is provided a patch that can be easily reduced in cost and can sufficiently prevent keratin exfoliation when peeling from the skin while ensuring sufficient adhesive force between the adhesive layer and the support. Is done.

  Hereinafter, preferred embodiments of the patch of the present invention will be described in detail.

  The patch of the present invention comprises a pressure-sensitive adhesive layer containing a predetermined amount of oil having compatibility with the pressure-sensitive adhesive composition and the pressure-sensitive polymer, an antistatic agent, and a support made of a nonwoven fabric or a woven fabric. And at least a body.

  Since the patch is used by being attached to the skin, an adhesive base (hereinafter sometimes simply referred to as “base”) is an essential component. Here, “adhesiveness” means having tack at least at the application temperature (temperature applied to the skin), and the elastic modulus E ′ at 1 Hz at the temperature is 0.1 MPa or less (Dahlquist's criterion). That's fine. As a base, if it shows such a property, you may use only 1 type or may use it in combination of 2 or more type. Typical base materials include an adhesive composition obtained by adding a tackifier to an elastomer, and an adhesive polymer containing an unsaturated monomer having 5 or more carbon atoms as a monomer unit.

  Adhesive compositions include tackifier compositions in which tackifiers are added to natural rubber to develop tackiness, adhesive compositions in which tackifiers are added to synthetic rubber to develop tackiness, and blends thereof In view of ease of formulation, a pressure-sensitive adhesive composition in which a tackifier is added to a synthetic rubber to develop pressure-sensitive properties is preferable. More preferred as such a composition is a thermoplastic elastomer added with a tackifier, and particularly preferred is a tacky composition obtained by adding a tackifier to a styrenic block copolymer.

  Examples of styrenic block copolymers include styrene-butylene-styrene block copolymer (SBS), styrene-isoprene-styrene block copolymer (SIS), styrene-ethylene / butylene-styrene block copolymer (SEBS), and styrene-ethylene / propylene-styrene block. A copolymer (SEPS) is mentioned. These styrenic block copolymers may have a skeleton of a linear body, a diblock body, a radial body, or a star body, but a linear body is preferable. Since the linear body may partially contain the diblock body on the synthesis route, a linear body partially containing the diblock body may be used. Moreover, a styrenic block copolymer may be used alone or in combination of two or more.

  Specific examples of the styrenic block copolymer include Califlex TR-1101, TR-1107 or Califlex TR-1111 (trade name, manufactured by Shell Chemical Co., Ltd.), JSR5000 or JSR5002 (trade name, Nippon Synthetic Rubber Co., Ltd.) Manufactured), Quintac 3530, 3421 or 3570C (trade name, manufactured by Nippon Zeon Co., Ltd.), Kraton D-KX401CS or D-1107CU (trade name, manufactured by Shell Chemical Co., Ltd.), Solprene 428 (trade name, Philippe Petroleum) Etc.).

  A styrene-based block copolymer is preferably a styrene-isoprene-styrene block copolymer having a styrene content of 10 to 30% by mass and a diblock content of 40% by mass or less, and particularly preferably a styrene content of 20%. A styrene-isoprene-styrene block copolymer having -30% by mass and a diblock content of 20% by mass or less. The styrene content is particularly preferably 20 to 25% by mass, and the diblock content is preferably 15% or less. By using such a styrenic block copolymer, a remarkable improvement can be achieved in all of the adhesion to the skin, prevention of exfoliation of the keratin, and anchoring properties of the support and the pressure-sensitive adhesive layer.

  A high styrene content such as 20% by mass or more and a low diblock content such as 20% by mass or less improve the hardness of the styrenic block copolymer and can be obtained by mixing with a tackifier. Although the hardness will also be improved, if you use such a hard styrene block copolymer and use oil with a higher content than previously used, a soft styrene block copolymer will be used from the beginning. Compared with the case where a small amount of oil is added thereto, more remarkable improvements can be achieved in all of adhesion to the skin, prevention of exfoliation of the skin, and anchoring properties of the support and the adhesive layer.

  The tackifier may be any resin that can impart tackiness to the elastomer, and includes rosin, rosin derivatives, terpene resins, hydrogenated terpene resins, dicyclopentadienyl resins, alicyclic saturated hydrocarbon resins, coumarone. Examples thereof include resins and indene resins. Considering the addition to the styrene-isoprene-styrene block copolymer, the tackifier is preferably a rosin resin based on rosin or a rosin derivative, such as rosin ester, hydrogenated rosin ester, maleic acid-modified rosin ester, etc. Can be suitably used. As such, Harrier Star L, S or P (trade name, manufactured by Harima Chemical Co., Ltd.), Superester A-75, or S-100, Pine Crystal KE-100 or KE-311, Ester Gum A AA-G, H or HP, Alcon P-70 (trade name, manufactured by Arakawa Chemical Industries, Ltd.), Harikon D, Foral 85, 100 or 105 (trade name, manufactured by Hercules Co., Ltd.), etc. One or a combination of two or more of these can be used.

  What is necessary is just to determine the compounding ratio of an elastomer and a tackifier so that tack may arise at least in application temperature (temperature stuck on skin). A typical blending amount is 10 to 1000 parts by mass (preferably 30 to 200 parts by mass, more preferably 30 to 150 parts by mass, still more preferably 40 to 120 parts by mass) with respect to 100 parts by mass of the elastomer. It is.

  In addition to an adhesive composition comprising an elastomer and a tackifier, an adhesive polymer containing an unsaturated monomer having 5 or more carbon atoms as a monomer unit can be used as a base. Examples of the adhesive polymer containing an unsaturated monomer having a total carbon number of 5 or more as a monomer unit include an adhesive polymer containing an alkyl (meth) acrylate having an alkyl group having 4 to 22 carbon atoms as a monomer unit. The polymer is tacky without the addition of a tackifier. Examples of the alkyl (meth) acrylate having 4 to 22 carbon atoms in the alkyl group include butyl (meth) acrylate, hexyl (meth) acrylate, octyl (meth) acrylate, 2-ethylhexyl acrylate, decyl (meth) acrylate, dodecyl (meth) ) Acrylate, tetradecyl (meth) acrylate, hexadecyl (meth) acrylate, octadecyl (meth) acrylate and the like. In addition, the adhesive polymer containing an unsaturated monomer having a total carbon number of 5 or more as a monomer unit may be used alone or in combination of two or more.

  The adhesive polymer is preferably a copolymer containing not only an alkyl (meth) acrylate having an alkyl group having 4 to 22 carbon atoms but also other monomers as monomer units. The other monomer is preferably a monomer having a glass transition temperature (measured at 5 ° C. by DSC) of 50 ° C. or higher when homopolymerized. Examples of such a monomer include (meth) acrylic acid, methyl (meth) acrylate, isobornyl (meth) acrylate, N-vinylpyrrolidone, and styrene.

In the case of a copolymer, the mass ratio of the alkyl (meth) acrylate having 4 to 22 carbon atoms of the alkyl group and other monomers is determined by using the Fox equation and the glass transition temperature (Tg) is the temperature at which the pressure-sensitive adhesive layer is used (typically Storage modulus at a working temperature (typically a room temperature of about 25 ° C.) by measuring the dynamic viscoelasticity (frequency of about 1 Hz) of the polymer. Can be set to the order of 10 ⁵ dyne / cm ² , but in general, the mass ratio of the former: the latter is 90 to 98: 2 to 10.

  The base having adhesiveness may be composed of a plurality of components. For example, a blend comprising two or more adhesive compositions comprising an elastomer and a tackifier, or two or more adhesive polymers comprising unsaturated monomers having a total carbon number of 5 or more as monomer units It may be a blend of Further, it may be a blend of an adhesive composition comprising an elastomer and a tackifier and an adhesive polymer containing an unsaturated monomer having 5 or more carbon atoms as a monomer unit. In this case, the blend ratio (mass ratio) of the former: the latter is preferably 10-90: 90-10, more preferably 20-80: 80-20. In addition, the base may contain an adhesive component other than the adhesive composition and the adhesive polymer.

  The patch contains an oil that is compatible with the above-mentioned adhesive composition and adhesive polymer, and the content of the oil is 100 parts by mass in total of the adhesive composition and the adhesive polymer. It is 60-200 mass parts.

  Here, the oil is not particularly limited as long as it is compatible with the above-described adhesive composition and adhesive polymer. Examples of such an oil include a liquid at room temperature and a hydrophobic polymer. Those that are compatible with the substance are used. Specifically, glycols such as ethylene glycol, diethylene glycol, triethylene glycol, propylene glycol, polyethylene glycol, and polypropylene glycol, and fats such as almond oil, olive oil, camellia oil, persic oil, peanut oil, castor oil, squalene, and lanolin Organic solvents such as ethyl acetate, ethyl alcohol, dimethyl sulfoxide, methyl octyl sulfoxide, dimethyl decyl sulfoxide, methyl octyl sulfoxide, dimethylformamide, dimethyl acetylamide, dimethyl lauryl amide, dodecyl pyrrolidone, isosorbitol, and liquid paraffin Hydrocarbons, ethoxylated stearyl alcohol, glycerin ester, phthalate ester, isopropyl myristate At least one selected from the group consisting of isotridecyl myristate, diethyl sebacate, ethyl laurate, N-methylpyrrolidone, ethyl oleate, oleic acid, diisopropyl adipate, isopropyl palmitate, and the like can be used. Among them, it is particularly preferable to use liquid paraffin.

  The content of oil is based on only “adhesive composition comprising an elastomer and a tackifier” and “adhesive polymer containing an unsaturated monomer having a total carbon number of 5 or more as a monomer unit” contained in the base. It is determined. For example, when the base contains a compound other than these (for example, polyisobutylene containing an unsaturated monomer having a total carbon of 4 as a monomer unit), the oil content is calculated even if it is sticky. It is not a standard.

  The present invention relates to a total of 100 parts by mass of “adhesive composition comprising an elastomer and a tackifier” and “adhesive polymer containing an unsaturated monomer having 5 or more total carbon atoms as a monomer unit”. When using parts by mass of oil, the adhesive force between the adhesive layer and the skin can be controlled appropriately, and when it is spread on a support containing an antistatic agent, it has excellent anchoring properties. It was made based on the new knowledge that it can be demonstrated. The oil content is more preferably 65 to 185 parts by mass and particularly preferably 70 to 170 parts by mass because the above properties are optimized. When the oil content is less than 60 parts by mass, the adhesive force between the adhesive layer and the skin becomes excessively strong, and the exfoliation may occur when the patch is peeled from the skin. If it exceeds the part, stickiness tends to occur, and the adhesive force to the skin becomes excessively weak, and the adhesive force between the support and the support becomes excessively weak, and the anchoring property to the support may be lowered. When the adhesive force between the support and the support is excessively weak, for example, when the patch is peeled from the skin, the adhesive layer is agglomerated and broken, causing the inconvenience that the adhesive layer remains on the skin.

  Examples of other compounding agents in the pressure-sensitive adhesive layer include drugs, antioxidants, fillers, crosslinking agents, preservatives, ultraviolet absorbers, absorption accelerators, and other various polymers (adhesive or non-adhesive). It is done.

  The drug contained in the adhesive layer of the patch of the present invention is not particularly limited, for example, acetaminophenone, phenacetin, mefenamic acid, diclofenac sodium, flufenamic acid, aspirin, sodium salicylate, methyl salicylate, glycol salicylate, Antipyretic analgesics such as aminopyrine, alclofenac, ibuprofen, naproxen, flurbiprofen, ketoprofen, sodium amphenac, mepyrizole, indomethacin, piroxicam, felbinac; steroidal anti-inflammatory drugs such as hydrocortisone, triamcinolone, dexamethasone, prednisolone hydrochloride, diltiazem hydrochloride Pentaerythritol tetranitrate, isosorbide nitrate, taradipyl, nicorandil, nitroglycerin, prenylamine lactate, molsidomine, Vasodilators such as aluminum nitrate, trazoline hydrochloride, nifedipine; arrhythmic agents such as procainamide hydrochloride, lidocaine hydrochloride, propranolol hydrochloride, alprenolol hydrochloride, atenolol, nadolol, metoprolol tartrate, ajmarin, disopyramide, mexiletine hydrochloride; ecarazine hydrochloride, Antihypertensive agents such as indapamide, clonidine hydrochloride, bunitrolol hydrochloride, labetalol hydrochloride, captopril, guanabenz acetate, mebutamate, betanidine sulfate; carbetapentane citrate, cloperastine, oxerazine tannate, cloptinol hydrochloride, clofedanol hydrochloride, noscapine hydrochloride, hydrochloride Ephedrine, isoproterenol hydrochloride, chloriprenaline hydrochloride, methoxyphenamine hydrochloride, procaterol hydrochloride, tulobuterol hydrochloride, Antifungal agents such as pterol and ketotifen fumarate; antineoplastic agents such as cyclophosphamide, fluorouracil, degafur, mitomycin C, procarbazine hydrochloride, doxyfluridine, ranimustine; ethyl aminobenzoate, tetracaine hydrochloride, brocaine hydrochloride, hydrochloric acid Local anesthetics such as dibucaine, oxybuprocaine hydrochloride, propitocaine hydrochloride; hormonal agents such as propylthiouracil, thiamazole, metellonone acetate, estradiol, estriol, progesterone; diphenhydramine hydrochloride, chlorpheniramine maleate, promethazine, diproheptazine hydrochloride, hydrochloric acid Antihistamines such as diphenylpyraline; anticoagulants such as warfarin potassium and ticlopidine hydrochloride; antispasmodic agents such as methyl atropine bromide and scopolamine General anesthetics such as sodium thiopental and sodium pentobarbital; hypnotics and analgesics such as bromvalenyl urea, amobarbital and phenobarbital; antidepressants such as sodium phenytoin; stimulants and stimulants such as methamphetamine hydrochloride; difendol hydrochloride and betahistine mesylate Antipruritic agents such as: Chlorpromazine hydrochloride, thioridazine, meprobamate, imipramine hydrochloride, chlordiazepoxide, diazepam and other neuropsychiatric agents; Skeletal muscle relaxants such as squismethonium hydrochloride and eperisone hydrochloride; Autonomic nerve agents such as neostigmine bromide and betanecol chloride; Antiparkinsonian agents such as amantadine hydrochloride; diuretics such as hydroflumethiazide, isosorbide, furosemide; vasoconstrictors such as phenylephrine hydrochloride; lobeline bromide, dimorpholamine, sodium chloride Respiratory stimulants such as roxone; peptic ulcers such as glycopyrronium bromide, proglumide, cetraxate hydrochloride, cimetidine, spizofuron; and other antibacterial agents such as ursodeoxycholic acid and osalmid; Urogenital and anal preparations such as: salicylic acid, ciclopirox olamine, colconazole hydrochloride and other parasitic skin disease agents; urea and other emollients; calcitriol, thiamine hydrochloride, riboflavin sodium phosphate, pyridoxine hydrochloride, Vitamins such as nicotinamide, panthenol, and ascorbic acid; inorganic preparations such as calcium chloride, potassium iodide, and sodium iodide; hemostatic agents of ethanesylate; agents for liver diseases such as thiopronin; for addictive poisoning such as cyanamide Agents: colchicine, probene Ventilation treatments such as sulfinpyrazone, sulfinpyrazone; Tolbutamide, Chlorpropamide, Glymidine sodium, Glypsol, Puformin hydrochloride, Insulin, etc .; Benzylpenicillin potassium, propicillin potassium, cloxacillin sodium, ampicillin sodium, hydrochloric acid Antibiotics such as bacampyricin, sodium carbenicillin, cephaloridine, cefoxitin sodium, erythromycin, chloramphenicol, tetracycline, kanamycin sulfate, cycloserine; chemotherapeutic agents such as isocyanide, pyrazinamide, etionamide; morphine hydrochloride, codin phosphate Narcotics such as cocaine hydrochloride, pethidine hydrochloride, fentanyl citrate, and the like.

  As the antioxidant, tocopherol and its ester derivatives, ascorbic acid, ascorbic acid stearate, nordihydroguaiaretic acid, dibutylhydroxytoluene, butylhydroxyasonyl and the like are preferable.

  Examples of the filler include calcium carbonate, magnesium carbonate, silicate (eg, aluminum silicate, magnesium silicate, etc.), silicic acid, barium sulfate, calcium sulfate, calcium zincate, zinc oxide, titanium oxide, zinc stearate, etc. Is preferred.

  Examples of the crosslinking agent include thermosetting resins (amino resins, phenol resins, epoxy resins, alkyd resins, unsaturated polyesters, etc.), isocyanate compounds, organic crosslinking agents such as blocked isocyanate compounds, and metals or metal compounds. Inorganic crosslinking agents are preferred.

  As the preservative, ethyl paraoxybenzoate, propyl paraoxybenzoate, butyl paraoxybenzoate and the like are preferable.

  As the ultraviolet absorber, p-aminobenzoic acid derivatives, anthranilic acid derivatives, salicylic acid derivatives, coumarin derivatives, amine acid compounds, imidazoline derivatives, pyridine derivatives, dioxane derivatives and the like are preferable.

  Absorption accelerators include terpene oils such as d-limonene, fatty acid esters such as glycerol monolaurate, glycerol monooleate, and diethyl sebacate, fatty acids such as azone, pyrothiodecane, oleic acid, lauric acid, myristic acid, and derivatives thereof. Is mentioned.

  Examples of the other polymer include a polymer containing an unsaturated monomer having 2 to 4 carbon atoms as a monomer unit, such as polyisobutylene, and the polymer may be adhesive or non-adhesive. When such a polymer component is added, the content is 5 to 15% by mass based on the total mass of the patch, and the total weight of the adhesive base and oil is 80 to 90% by mass based on the same standard. It is preferable.

The patch of the present invention is constituted by plastering the above-mentioned pressure-sensitive adhesive layer on a support. In this case, the pressure-sensitive adhesive layer is applied on the support so that the coating amount is 50 to 300 g / m ^2. It is preferable to form. More preferably 60~250g / ^{m 2,} more preferably from 80~210g / ^{m 2.}

  As the support constituting the patch of the present invention, a non-woven fabric or a woven fabric containing an antistatic agent is used for preventing static electricity from accumulating on the support and for good anchoring properties with the adhesive layer. Use.

  The support is not limited to a single layer structure, and may be a laminated structure. For example, it may be a structure in which a plurality of nonwoven fabrics or woven fabrics made of different materials are laminated, or a structure in which a plastic film, a metal foil or the like and a nonwoven fabric or woven fabric are laminated. The non-woven fabric or woven fabric can be formed of a material usually used for the support of the patch, but as a preferred example, a non-woven fabric or a combination of one or more polyester-based, polyethylene-based, or polypropylene-based materials A woven fabric is mentioned, and among them, a woven fabric made of polyester-based polyethylene terephthalate that has little interaction with drugs is more preferable.

  Furthermore, the woven fabric is not limited as long as it has an adhesive layer and excellent anchoring properties, but if it is a polyester-based knitted fabric by multi-stage double-sided knitting multifilament yarn constructed by crimping, Furthermore, a preferable anchoring property and a feeling of use at the time of sticking can be obtained.

  That is, when a support containing the antistatic agent shown below is used for the patch on a knitted fabric knitted by such a knitting method, a part of the pressure-sensitive adhesive layer penetrates into the inside of the support, which is even better. It will have a throwing ability.

Moreover, when using a polyethylene terephthalate woven fabric from the above, it is preferable that the fabric weight is 80-150 g / m < ² >. If it is this range, when apply | coating an adhesive layer to a woven fabric, an adhesive layer does not ooze out through the mesh | network of a woven fabric, and anchorage with an adhesive layer can be maintained. The polyethylene terephthalate woven fabric preferably has a longitudinal (major axis) modulus of 2 to 12 N / 5 cm and a transverse (minor axis direction) modulus of 2 to 8 N / 5 cm (measurement method: JIS L 1018). When the adhesive layer has a modulus lower than 2 N / 5 cm, the woven fabric is stretched when the adhesive layer is applied, and the adhesive layer penetrates into the mesh, and the function as a patch tends to be reduced. In addition, 12 N / 5 cm (longitudinal direction) ) Or a modulus higher than 8 N / 5 cm (lateral direction), the stretchability is poor, and when applied to a bent part of the body, there is a tendency not to follow the stretching of the skin.

The antistatic agent contained in the support is not particularly limited as long as it has the effects of the present invention, but a surfactant is preferably used as the antistatic agent. The surfactant may be any of an anionic surfactant, a cationic surfactant, a nonionic surfactant and an amphoteric surfactant, and one or more of these may be used in combination. As the surfactant, an anionic surfactant is particularly preferable because of its relationship with the material of the support (for example, polyester is easily negatively charged). In order to obtain a high antistatic effect and a high anchoring property between the support and the pressure-sensitive adhesive layer, the content of the antistatic agent contained in the support is 0.05 to 2% by mass based on the total mass of the support. It is preferable that it is 0.05-1 mass%.

  The anionic surfactant is not particularly limited, and examples thereof include fatty acid salts (such as sodium stearate, sodium laurate, triethanolamine laurate), alkylbenzene sulfonates (such as sodium dodecylbenzene sulfonate), alkyl sulfonates, α -Olefin sulfonate, monoalkyl sulfosuccinate, dialkyl sulfosuccinate, α-sulfonated fatty acid salt, acylmethyl taurate, N-methyl-N-alkyl taurate, polyoxyethylene alkyl ether sulfate, polyoxyethylene Alkylphenyl ether sulfate, alkyl phosphate, polyoxyethylene alkyl ether phosphate, polyoxyethylene alkylphenyl ether phosphate, N-acyl amino acid salt, N-acyl-N-alkyl amino acid salt, poly Examples include oxyethylene alkylphenyl ether sulfonate, alkyl naphthalene sulfonate, alkyl diphenyl ether disulfonic acid, polyoxyethylene alkyl ether sulfosuccinate, polyoxyethylene alkyl ether acetate, alkenyl succinate, and their acids. . These anionic surfactants may be used alone or in combination of two or more.

  The cationic surfactant is not particularly limited. For example, a long-chain alkyl short-chain trialkylammonium salt (lauryltrimethylammonium chloride, myristyltrimethylammonium chloride, palmityltrimethylammonium chloride, stearyltrimethylammonium chloride), long-chain dialkyl short-chain dia Lucur ammonium salt, (distearyl allyl ammonium chloride), alkyl pyridinium salt (myristyl pyridinium chloride, cetyl pyridinium chloride, stearyl pyridinium chloride, etc.), alkyl imidazolinium salt (1,1-dimethyl-2-hexadecyl imidazolinium) Chloride), benzyl long-chain alkyl short-chain dialkylammonium salts (benzalkonium chloride, benzethonium chloride, etc.), and their derivatives Is mentioned. These cationic surfactants may be used alone or in combination of two or more.

  The nonionic surfactant is not particularly limited, and for example, glycerin fatty acid ester and its alkylene glycol adduct, polyglycerin fatty acid ester and its alkylene glycol adduct, propylene glycol fatty acid ester and its alkylene glycol adduct, propylene glycol fatty acid ester and Its alkylene glycol adduct, sorbitan fatty acid ester and its alkylene glycol adduct, sorbitol fatty acid ester and its alkylene glycol adduct, polyalkylene glycol fatty acid ester, sucrose fatty acid ester, polyoxyalkylene alkyl ether, glycerin alkyl ether, polyoxyethylene Alkyl phenyl ether, polyoxyethylene hydrogenated castor oil, lanolin alkylene Recall adducts, polyoxyalkylene alkyl co-modified silicone, polyether-modified silicone, and the like. These nonionic surfactants may be used alone or in combination of two or more.

  The amphoteric surfactant is not particularly limited. For example, betaine acetate type amphoteric surfactant (lauryldimethylaminoacetic acid betaine, stearyldimethylaminoacetic acid betaine, myristylaminoacetic acid betaine, lauric acid amidopropylacetic acid betaine, etc.), alkylamine oxide type amphoteric Surfactant (alkyldimethylamine oxide, etc.), imidazoline type double-sided activator (2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, 2-cococoyl-N-carboxymethyl-N-hydroxymethyl imidazole) Nitrobetaine, 2-lauryl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, etc.), sulfobetaine-type amphoteric surfactants and the like. These amphoteric surfactants may be used alone or in combination of two or more.

  The support made of a nonwoven fabric or a woven fabric containing the antistatic agent preferably has a charged voltage of −50 to −4000 V after the chargeability test specified in JIS L 1094, and preferably has a voltage of −100 to −3000 V. More preferably, it is -500 to -3000V. In addition, in the support whose charging voltage after the charging test is smaller than −4000 V (absolute voltage has a large absolute value), not only is the wrinkle easily generated by static electricity, but also the anchoring property when the adhesive layer is spread. There is a tendency that the adhesive layer peels off from the support after spreading, or the adhesive layer remains on the skin after the patch is applied to the affected area. On the other hand, in the support having a charged voltage after the chargeability test of greater than −50 V (the absolute value of the charged voltage is small), the anchoring property of the pressure-sensitive adhesive layer tends to decrease. That is, by using a support in which the charged voltage after the chargeability test is in the above range, not only can the production efficiency be reduced due to static electricity, but also the anchoring property of the pressure-sensitive adhesive layer and the support can be made more favorable. It becomes possible.

  As a method for incorporating the surfactant into the nonwoven fabric or woven fabric, a known method for imparting an antistatic agent to fibers such as clothing can be used. For example, the nonwoven fabric or woven fabric is immersed in an aqueous solution containing a surfactant, and the surfactant is adsorbed on the nonwoven fabric or woven fabric, and then dried.

  The present invention will be described in more detail based on the following examples, but the present invention is not limited to these examples.

<Example 1>
A predetermined amount of each component shown in Table 1 was weighed and mixed to obtain a paste.

Meanwhile, polyethylene terephthalate woven fabric (100 g / m ² in basis weight, longitudinal modulus 10 N / 5 cm, lateral modulus 5 N / 5 cm) and anionic surfactant (Delectol KC: manufactured by Meisei Chemical Co., Ltd.) in terms of solid content About 0.1% by mass was adsorbed. The charged voltage after the chargeability test of the support thus obtained was −2000V. The chargeability test was carried out in accordance with JIS L 1094, using cotton as a friction cloth and tested in an environment of 20 ° C. and humidity 40% RH.

Then, the plaster was spread on one side of the support by a hot melt method to form an adhesive layer, and then cut into a desired size to obtain a tape-like patch.

<Example 2>
A predetermined amount of each component shown in Table 2 was weighed and mixed under the same conditions as in Example 1 to obtain a paste.

On the other hand, an anionic surfactant (Nicepol PR-99: manufactured by Nikka Chemical Co., Ltd.) is converted into solid content on a polyethylene terephthalate woven fabric (weighing 80 g / m ² , longitudinal modulus 4 N / 5 cm, transverse modulus 3 N / 5 cm). And about 0.5% by mass was adsorbed with respect to the total mass. The charged voltage after the chargeability test of the support thus obtained was -1000V. The chargeability test was performed in the same manner as in Example 1.

Then, the plaster was spread on one side of the support by a hot melt method to form an adhesive layer, and then cut into a desired size to obtain a tape-like patch.

<Example 3>
A predetermined amount of each component shown in Table 3 was weighed and mixed under the same conditions as in Example 1 to obtain a paste.

Meanwhile, polyethylene terephthalate woven fabric (weighing 140 g / m ² , longitudinal modulus 12 N / 5 cm, transverse modulus 7 N / 5 cm) and anionic surfactant (Delectol KC: manufactured by Meisei Chemical Co., Ltd.) in terms of solid content About 0.05% by mass was adsorbed. The charged voltage after the chargeability test of the support thus obtained was -3900V. The chargeability test was performed in the same manner as in Example 1. The plaster was spread on one side of the support by a hot melt method to form an adhesive layer, and then cut into a desired size to obtain a tape-like patch.

<Example 4>
A predetermined amount of each component shown in Table 4 was weighed and mixed under the same conditions as in Example 1 to obtain a paste.

On the other hand, a nonionic surfactant (Nice Pol EF-26: manufactured by Nikka Chemical Co., Ltd.) is solidified on a polyethylene terephthalate woven fabric (weighing 120 g / m ² , longitudinal modulus 8 N / 5 cm, transverse modulus 4 N / 5 cm). About 0.1% by mass was adsorbed with respect to the total mass in terms of minutes. The charged voltage after the chargeability test of the support thus obtained was −3000V. The chargeability test was performed in the same manner as in Example 1.

Then, the plaster was spread on one side of the support by a hot melt method to form an adhesive layer, and then cut into a desired size to obtain a tape-like patch.

<Comparative Example 1>
A predetermined amount of each component shown in Table 5 was weighed and mixed under the same conditions as in Example 1 to obtain a paste.

On the other hand, a polyethylene terephthalate woven fabric (weighing 100 g / m ² , longitudinal modulus 10 N / 5 cm, lateral modulus 5 N / 5 cm) was used as a support. The charged voltage after the chargeability test of this support was -6000V. The plaster was spread on one side of the support by a hot melt method to form an adhesive layer, and then cut into a desired size to obtain a tape-like patch.

<Comparative example 2>
A predetermined amount of each component shown in Table 5 was weighed and mixed under the same conditions as in Example 1 to obtain a paste.

On the other hand, a polyethylene terephthalate woven fabric (weighing 100 g / m ² , longitudinal modulus 10 N / 5 cm, transverse modulus 5 N / 5 cm) was used as a support. The charged voltage after the chargeability test of this support was -6000V. The plaster of Comparative Formulation Example 2 was spread on one side of the support by a hot melt method to form an adhesive layer, and then cut into a desired size to obtain a tape-like patch.

<Comparative Example 3>
Polyethylene terephthalate woven fabric (100 g / m ² per unit area, longitudinal modulus 10 N / 5 cm, transverse modulus 5 N / 5 cm) non-ionic surfactant (Nice Pol EF-26: manufactured by Nikka Chemical Co., Ltd.) as solid content And about 0.1% by mass with respect to the total mass. The charged voltage after the chargeability test of the support thus obtained was −3000V. After the plaster of Comparative Example 2 was spread on one side of the support by the hot melt method to form an adhesive layer, it was cut into a desired size to obtain a tape-like patch.

The chargeability test of the support used in Comparative Examples 1 to 3 was performed in the same manner as in Example 1.

<Evaluation>
The following points were evaluated for the patches of Examples 1-4 and Comparative Examples 1-3 produced as described above.

(Manufacturability)
In the manufacturing process of the patches of the above Examples and Comparative Examples, the occurrence of defective products was observed. Manufactured products with good manufacturability that are not observed when such defects are found to be "bad" due to static electricity accumulated on the substrate due to static or accumulated on the substrate during production. Was evaluated as “good”. The results are shown in Table 6.

(Throwing property)
The patches of the above Examples and Comparative Examples were applied to the inside of the upper arm of 10 healthy adult males for 8 hours, and the remaining plaster after detachment was observed. The case where there was no remaining plaster was designated as “A”, the case where some remaining plaster was recognized as “B”, and the case where significant remaining plaster was observed as “C”. The results are shown in Table 6.

表６に示す結果より、実施例１〜４の貼付剤は、比較例１〜３の貼付剤に比べて、支持体と粘着剤層との間の投錨性に優れ、且つ貼付剤を剥離した後の角質の剥離が十分に防止できることが分かった。更に、実施例１〜４の貼付剤は、比較例１〜３の貼付剤に比べて、製造性が良好となることが分かった。
従って、本発明の貼付剤によれば、低コスト化が容易であり、粘着剤層と支持体との間に十分な粘着力を確保しながら、皮膚から剥離する際に角質剥離を十分に防止できることが確認された。 (Exfoliation)
About the patch which performed the said anchoring property test, the surface of the adhesive layer was dye | stained over the day and night with the amide black dyeing | staining liquid containing 0.25 mass% amide black. The staining solution was prepared by dissolving Amido Black 10B manufactured by Kanto Chemical Co., Ltd. in a mixed solvent of water, acetic acid and methanol (water: acetic acid: methanol = 45: 10: 45 (mass ratio)). After dyeing, the patch was washed with water and a washing solution (water: acetic acid: methanol = 8: 2: 90) for 15 minutes or more. About the patch processed in this way, the presence or absence of exfoliation was observed by observing the surface of the adhesive. When the stratum corneum is hardly recognized on the surface of the pressure-sensitive adhesive layer, it is assumed that the exfoliation can be sufficiently prevented, and “A” is obtained. In the case where the stratum corneum was considerably observed on the surface of the pressure-sensitive adhesive, it was evaluated as “C” because there was significant exfoliation. The results are shown in Table 6.

From the results shown in Table 6, the patches of Examples 1 to 4 were excellent in anchoring properties between the support and the pressure-sensitive adhesive layer as compared with the patches of Comparative Examples 1 to 3, and the patches were peeled off. It was found that exfoliation of the keratin later can be sufficiently prevented. Furthermore, it was found that the patches of Examples 1 to 4 were more manufacturable than the patches of Comparative Examples 1 to 3.
Therefore, according to the patch of the present invention, cost reduction is easy, and the keratin exfoliation is sufficiently prevented when exfoliating from the skin while ensuring sufficient adhesive force between the adhesive layer and the support. It was confirmed that it was possible.

Claims (8)

In a patch comprising a support and an adhesive layer provided on the support,
The pressure-sensitive adhesive layer contains an adhesive base, oil, and drug, and the base is an adhesive composition composed of at least an elastomer and a tackifier, and / or unsaturated with a total carbon number of 5 or more. Composed of an adhesive polymer containing a monomer as a monomer unit,
The oil is an oil compatible with the adhesive composition and the adhesive polymer,
The content of the oil is 60 to 200 parts by mass with respect to a total of 100 parts by mass of the adhesive composition and the adhesive polymer,
The patch is characterized in that the support is a nonwoven fabric or a woven fabric containing an antistatic agent.   The patch according to claim 1, wherein the elastomer is a styrenic block copolymer.   The patch according to claim 1 or 2, wherein the elastomer is a styrene-isoprene-styrene block copolymer having a styrene content of 10 to 30% by mass and a diblock content of 40% by mass or less.   4. The adhesive polymer according to claim 1, wherein the adhesive polymer is an adhesive polymer containing an alkyl (meth) acrylate having an alkyl group having 4 to 22 carbon atoms as a monomer unit. 5. Patch.   The patch according to any one of claims 1 to 4, wherein the oil is liquid paraffin.   The antistatic agent is at least one selected from the group consisting of a nonionic surfactant, an anionic surfactant, a cationic surfactant, and an amphoteric surfactant. The patch according to any one of the above.   The patch according to any one of claims 1 to 5, wherein the antistatic agent is an anionic surfactant.   The patch according to any one of claims 1 to 7, wherein the nonwoven fabric or woven fabric is made of polyester, polyethylene, or polypropylene.