JP2006312611A - Hair grower and hair cosmetic - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hair grower containing Acer palmatum extract, and to provide hair cosmetics each compounded with the hair grower. <P>SOLUTION: The hair grower comprises the extract of Acer palmatum as a subtall deciduous tree belonging to Aceraceae plant family. As a preferable embodiment of this hair grower, it has testosterone 5α-reductase inhibitory activity. The hair cosmetics each containing the above extract include hair tonic, hair cream, hair liquid, shampoo, pomade and rinse. <P>COPYRIGHT: (C)2007,JPO&INPIT

Description

  The present invention relates to a hair restorer containing an extract of Japanese maple and a hair cosmetic containing the hair restorer as an active ingredient.

Testosterone, a kind of male hormone, is reduced to dihydrotestosterone by the reductase testosterone-5α-reductase. When this produced dihydrotestosterone accumulates in the scalp, it is known to cause hair loss by causing hair roots to contract. Therefore, it is considered that hair loss can be prevented and treated by suppressing or inhibiting the production of dihydrotestosterone.
Examples of herbal medicine extracts having testosterone-5α reductase inhibitory activity include extracts of plants belonging to the genus Cholerospondias (see Patent Document 1), extracts of majito and cuta extract (see Patent Document 2), Gojo. An extract of a child (see Patent Document 3), any extract selected from red bean cedar, bird cage, hooded umbrella, and centripetal lotus (see Patent Document 4), and the like have been proposed.

  Thus, there is a strong demand from consumers for a natural hair restorer that is excellent in safety and productivity, and that is inexpensive but has an excellent testosterone 5α-reductase inhibitory effect, and a hair cosmetic that contains the hair restorer, At present, there are no products that can meet the demand.

JP 2003-055162 A JP 2002-241297 A JP 2002-241296 A JP 2002-087976 A

  An object of the present invention is to solve the conventional problems and achieve the following objects. That is, an object of the present invention is to provide a hair growth agent having an excellent testosterone 5α-reductase inhibitory action and a hair cosmetic composition having an excellent hair growth action formed by blending the hair growth agent.

  As a result of intensive studies by the present inventors in order to solve the above problems, it has been found that the extract of Japanese maple has an excellent testosterone 5α-reductase inhibitory action and is useful as a hair restorer. Moreover, it discovered that the hair cosmetics which mix | blended the extract of Japanese maple as an active ingredient have the outstanding hair growth effect | action.

The present invention is based on the above findings by the present inventors, and means for solving the above problems are as follows. That is,
<1> A hair restorer comprising an extract of Japanese maple.
<2> The hair restorer according to <1>, which has a testosterone 5α-reductase inhibitory action.
<3> A hair cosmetic comprising the hair restorer according to any one of <1> to <2> as an active ingredient.

According to the hair restorer of the present invention, the action of male hormone can be suppressed through the testosterone 5α-reductase inhibitory action, which is extremely useful for the prevention and treatment of male pattern baldness. Moreover, since the hair restorer of this invention is excellent in a usability | use_condition and safety | security, it is suitable for mix | blending with hair cosmetics.
Since the hair cosmetic composition of the present invention is formed by blending the hair restorer of the present invention, it has an excellent hair restoring effect.

(Hair restorer)
The hair restorer of the present invention contains an extract of Japanese maple, and further contains other components as necessary.

The maple tree (scientific name: Acer palmatum ) is a deciduous sub-tree of the genus Kaede, and is also called maple tree, maple tree, maple maple. This maple is distributed in areas such as Honshu, Shikoku, Kyushu, southern Korea, and eastern China, and is easily available from these areas.
The Japanese maple leaves are divided into 5 to 9 palm-like leaves and have a slightly rough sawtooth. In autumn, the leaves turn red and are very beautiful, so many horticultural varieties have been made since the Edo period, and it is one of the plants that have been popular since ancient times. It has not been known so far that this extract of Japanese maple has a testosterone 5α-reductase inhibitory action and is effective as a hair restorer, and these are new findings by the present inventors.

  Although the details of the substance having testosterone 5α-reductase inhibitory activity of the extract of Acer palmatum are unknown, it can be easily obtained by a method generally used for plant extraction. In addition, the extract of Acer palmatum includes an extract of Acer palmatum, a dried product obtained by drying a diluted solution of the extract, or a crudely purified product or a purified product thereof.

  There is no particular limitation on the raw material for the extraction of the Japanese maple, and it can be appropriately selected according to the purpose.For example, it is possible to use components such as leaves, branches, bark, stems, seeds, and roots. Among these, the leaf portion is particularly preferable because it has a high testosterone 5α-reductase inhibitory action.

  The leaf part of the Japanese maple, which is the raw material for extraction, can be obtained by drying or pulverizing it as it is or using a crusher and subjecting it to solvent extraction. Drying may be performed in the sun or using a commonly used dryer. In addition, you may use the leaf part of the said Japanese maple after performing pretreatments, such as a degreasing | defatting, by nonpolar solvents, such as hexane and benzene. In addition, by performing pre-processing, such as degreasing, the extraction process by the polar solvent of Japanese maple can be performed efficiently.

As the solvent used for the extraction, it is preferable to use water, a hydrophilic organic solvent, or a mixture thereof at room temperature or a temperature not higher than the boiling point of the solvent.
Examples of water that can be used as the extraction solvent include pure water, tap water, well water, mineral spring water, mineral water, hot spring water, spring water, fresh water, and the like, as well as water that has been subjected to various treatments. Examples of the treatment applied to water include purification, heating, sterilization, filtration, ion exchange, adjustment of osmotic pressure, buffering, and the like. Therefore, the water that can be used as the extraction solvent includes purified water, hot water, ion exchange water, physiological saline, phosphate buffer, phosphate buffered saline, and the like.

The hydrophilic organic solvent is not particularly restricted and may be appropriately selected according to purpose. Examples thereof include lower alcohols having 1 to 5 carbon atoms such as methanol, ethanol, propyl alcohol and isopropyl alcohol; acetone, methyl ethyl ketone and the like Lower aliphatic ketones; C2-C5 polyhydric alcohols such as 1,3-butylene glycol, propylene glycol, glycerin and the like, and a mixed solvent of these hydrophilic organic solvents and water can be used. .
In addition, when using the mixed solvent of the said water and a hydrophilic organic solvent, in the case of a lower alcohol, it is 1-90 mass parts with respect to 10 mass parts of water, and in the case of a lower aliphatic ketone, it is 10 mass parts of water. It is preferable to add 1-40 mass parts with respect to it. In the case of a polyhydric alcohol, it is preferable to add 1 to 90 parts by mass with respect to 10 parts by mass of water.

  In the present invention, it is not necessary to adopt a special extraction method for extracting a substance having testosterone 5α-reductase inhibitory action from the Japanese maple, which is an extraction raw material, and it is extracted using any apparatus at room temperature or under reflux heating. Can do.

  Specifically, after adding the leaf portion of Japanese maple as an extraction raw material to a treatment tank filled with the extraction solvent, and standing still for 30 minutes to 2 hours with occasional stirring as necessary to elute soluble components The solid matter is removed by filtration, and the extract is distilled off from the resulting extract and dried to obtain an extract. The amount of the extraction solvent is usually 5 to 15 times (mass ratio) of the extraction raw material. The extraction conditions are usually about 1 to 4 hours at 50 to 95 ° C. when water is used as the extraction solvent. When a mixed solvent of water and ethanol is used as the extraction solvent, it is usually about 30 minutes to 4 hours at 40 to 80 ° C. In addition, the extract obtained by extracting with a solvent can be blended as it is and used as the hair restorer of the present invention if the extraction solvent is highly safe.

  In order to obtain the extract of Acer palmatum, a diluted or concentrated solution of the extract, a dried product of the extract, or a crude purified product or a purified product thereof, dilution, concentration, drying, purification, etc. You may perform the process of.

  In addition, although the obtained extract of Acer palmatum can be used as it is as a hair restorer, a concentrated solution or a dried product thereof is easier to use. In obtaining a dried extract, a carrier such as dextrin or cyclodextrin may be added to improve hygroscopicity. Moreover, although the said Japanese maple has a peculiar smell, it is not unpleasant and can be used as it is as a raw material for hair cosmetics. In addition, if necessary, purification for the purpose of decolorization, deodorization and the like can be performed within a range not causing a decrease in physiological activity, and it may be formulated by mixing with any auxiliary agent.

  The hair restorer of the present invention can suppress the action of male hormones through an excellent testosterone 5α-reductase inhibitory action, is useful for the prevention and treatment of male pattern baldness, and may be applied directly to the hair. However, it is preferably used by blending with various cosmetics, and can be particularly suitably used for the following hair cosmetics of the present invention.

(Hair cosmetic)
The hair cosmetic composition of the present invention contains the hair-restoring agent of the present invention, and further contains other components appropriately selected as necessary.
The extract of Japanese maple contained in the hair restorer has an excellent hair-growth action and is excellent in feeling of use and safety. Can provide an excellent hair-growth effect.

  Here, there is no restriction | limiting in particular as a use of the said hair cosmetics, It can select suitably from various uses, For example, a hair tonic, a hair cream, a hair liquid, a shampoo, a pomade, a rinse, etc. are mentioned.

  The blending amount of the hair restorer with respect to the entire hair cosmetic is not particularly limited and can be appropriately selected depending on the type of the hair cosmetic, the physiological activity of the extract, and the like. 0001-10 mass% is preferable and 0.001-1 mass% is more preferable.

  The hair cosmetic containing the hair restorer may further contain various main ingredients and auxiliaries usually used in the production of the hair cosmetic, as long as the effects of the present invention are not impaired, if necessary. it can.

-Other ingredients-
The other components are not particularly limited as long as they do not interfere with the hair-restoring action, and include components appropriately selected according to the purpose, such as astringents, bactericides, antibacterial agents, ultraviolet absorbers, humectants, Examples include cell activators, anti-inflammatory agents, antioxidants, active oxygen scavengers, fats and oils, waxes, hydrocarbons, fatty acids, alcohols, esters, surfactants, perfumes, and the like. These components may act synergistically when used in combination with the above-mentioned Japanese maple extract, resulting in superior effects than expected.

  The hair cosmetic composition of the present invention has high safety and can suppress the action of androgen through the excellent testosterone 5α-reductase inhibitory action of the extract of the Japanese maple extract, which is an active ingredient. Very useful for prevention and treatment.

  The hair-restoring agent and hair cosmetic composition of the present invention are preferably applied to humans, but are not particularly limited as long as their respective effects are exhibited, and are applied to animals other than humans. You can also

  Examples of the present invention will be described below, but the present invention is not limited to these examples.

(Production Example 1)
-Production of water extract of Japanese maple-
Water (1000 mL) was added to 100 g of the dried leaf of the Japanese maple leaf, extracted with a reflux extractor at 80 ° C. for 2 hours, and filtered while hot. The same extraction process was performed on the residue. The obtained extracts were combined, concentrated under reduced pressure, and further dried to obtain a water extract of Japanese maple. The yield of the extract is shown in Table 1.

(Production Example 2)
-Production of 50% by weight ethanol extract of Japanese maple-
1000 g of 50% ethanol (mass ratio of water to ethanol: 1: 1) is added to 100 g of dried leafy leaf leaves, extracted with a reflux extractor at 80 ° C. for 2 hours, and filtered while hot did. The same extraction process was performed on the residue. The obtained extracts were combined, concentrated under reduced pressure, and further dried to obtain a 50% by weight ethanol extract of Japanese maple. The yield of the extract is shown in Table 1.

(Production Example 3)
-Production of ethanol extract of Japanese maple-
Ethanol (1000 mL) was added to 100 g of the dried leaf of the Japanese maple leaf, extracted with a reflux extractor at 80 ° C. for 2 hours, and filtered while hot. The same extraction process was performed on the residue. The obtained extracts were combined, concentrated under reduced pressure, and further dried to obtain an ethanol extract of Japanese maple. The yield of the extract is shown in Table 1.

Example 1
-Testosterone 5α-reductase inhibitory action test-
About each Acer palmatum extract obtained in manufacture examples 1-3, the testosterone 5 (alpha) -reductase inhibitory effect was tested as follows.
First, 20 μL of 4.2 mg / mL testosterone prepared with propylene glycol and 825 μL of 5 mmol / mL Tris-HCl buffer (pH 7.13) containing 1 mg / mL NADPH were mixed in a V-bottom test tube with a lid. . To this, 80 μL of the extract of Production Examples 1 to 3 (hereinafter referred to as “test sample”) and 75 μL of rat liver homogenate (S-9) were added and mixed again, and reacted at 37 ° C. for 30 minutes. The reaction was stopped by adding 1 mL of methylene chloride. This was centrifuged (1600 × g, 10 minutes), and the methylene chloride layer was analyzed by gas chromatography under the following conditions. A blank test was conducted in the same manner.

-Gas chromatography analysis-
In advance, 3α-androstanediol, dihydrotestosterone (DHT), and methylene chloride solutions of standard testosterone were analyzed by gas chromatography in the same manner. In addition, the concentrations per peak area of 3α-androstanediol, dihydrotestosterone (DHT), and testosterone after the reaction with S-9 were determined (see Formula 1 below). Then, according to following Numerical formula 2, the conversion rate of each test sample was calculated | required. Based on the obtained conversion rate, the testosterone 5α-reductase activity inhibition rate was determined by the following formula 3.

<Formula 1>
Concentration (%) = (peak area of test sample × standard product concentration) / peak area of standard product

<Formula 2>
Conversion rate (%) = (A + B) / (A + B + C)
In Formula 2, A represents the concentration of 3α-androstanediol. B represents the concentration of dihydrotestosterone (DHT). C represents the concentration of testosterone.

<Formula 3>
Testosterone 5α-reductase activity inhibition rate (%) = (1−E / D) × 100
In Equation 3, D represents the conversion rate in the blank test. E represents the conversion rate when the test sample is added.

<Conditions for gas chromatography>
Equipment used: Shimadzu GC-7A (manufactured by Shimadzu Corporation)
Column: DB-1701 (diameter 0.53 mm × 30 m, film thickness: 1.0 μm)
Column temperature / injection temperature: 240 ° C./300° C.
Detector: FID
Carrier gas: Nitrogen gas

  Subsequently, the sample concentration of the test sample is decreased stepwise, the testosterone 5α-reductase activity inhibition rate is measured, and the sample concentration (μg / mL) that inhibits the activity of testosterone 5α-reductase by 50% is interpolated. Determined by The results are shown in Table 2.

表２の結果から、製造例１〜３の各イロハモミジの抽出物は、テストステロン５α−リダクターゼ阻害作用を有することが分かった。また、テストステロン５α−リダクターゼ阻害作用の程度は、抽出物の濃度によって調節できることが確認できた。

From the results of Table 2, it was found that the extracts of each maple of Production Examples 1 to 3 have testosterone 5α-reductase inhibitory action. It was also confirmed that the degree of testosterone 5α-reductase inhibitory action can be adjusted by the concentration of the extract.

(Formulation Example 1)
-Hair tonic-
A hair tonic having a hair nourishing action having the following composition was produced by a conventional method.
0.1 g of pyridoxine hydrochloride
Resorcin 0.01g
D-pantothenyl alcohol 0.1g
0.1g dipotassium glycyrrhizinate
l-Menthol 0.05g
1,3-butylene glycol 4.0 g
Carrot extract 0.5g
Ethanol 25.0g
0.2 g of 50% by weight ethanol extract of Japanese maple (Production Example 2)
Perfume
Purified water balance
Total 100.0g

(Formulation Example 2)
-Shampoo-
A shampoo (cream shampoo) having a hair nourishing action having the following composition was produced by a conventional method.
Sodium polyoxyethylene alkyl ether sulfate 30.0g
Polyoxyethylene alkyl ether ammonium sulfate 20.0g
Coconut oil fatty acid amidopropyl betaine 6.0g
Coconut oil fatty acid modiethanolamide 4.0g
2.0g ethylene distearate
Preservative (Methyl paraoxybenzoate) 0.15g
0.2 g of water extract of Japanese maple (Production Example 1)
Mukuroji extract 0.2g
Twilight extract 0.5g
Oat extract 0.3g
Rosemary extract 0.5g
Fragrance 0.01g
1,3-butylene glycol 3.0 g
Purified water balance
Total amount 100.0g

(Formulation Example 3)
-Rinse-
A rinse having a hair nourishing action having the following composition was produced by a conventional method.
Stearyltrimethylammonium chloride 1.5g
Polyoxyethylene cetyl ether 1.0g
Cetyl alcohol 2.0g
Octyldodecanol 1.0g
Cationized cellulose 0.5g
Propylene glycol 5.0g
0.2 g of water extract of Japanese maple (Production Example 1)
Mukuroji extract 0.2g
Twilight extract 0.5g
Oat extract 0.3g
Rosemary extract 0.5g
Fragrance 3.0g
Purified water balance
Total amount 100.0g

(Formulation Example 4)
-Rinse-
A rinse having a hair nourishing action having the following composition was produced by a conventional method.
Stearyltrimethylammonium chloride 1.5g
Polyoxyethylene cetyl ether 1.0g
Cetyl alcohol 2.0g
Octyldodecanol 1.0g
Cationized cellulose 0.5g
Propylene glycol 5.0g
0.2 g of ethanol extract of Japanese maple (Production Example 3)
Mukuroji extract 0.2g
Twilight extract 0.5g
Oat extract 0.3g
Rosemary extract 0.5g
Fragrance 3.0g
Purified water balance
Total amount 100.0g

The hair restorer of the present invention and the hair cosmetic composition containing the same have an excellent testosterone 5α-reductase inhibitory action, and can suppress the action of male hormones through the testosterone 5α-reductase inhibitory action, thereby eliminating male hair loss. It is useful for at least one of prevention and treatment of diseases and the like, and is widely used for hair tonic, hair cream, hair liquid, shampoo, pomade, rinse, and the like.

Claims (3)

  A hair restorer comprising an extract of Japanese maple.   The hair restorer according to claim 1, which has a testosterone 5α-reductase inhibitory action. A hair cosmetic comprising the hair restorer according to claim 1 as an active ingredient.