JP2006312589A - Composition for oral cavity - Google Patents
Composition for oral cavity Download PDFInfo
- Publication number
- JP2006312589A JP2006312589A JP2005134741A JP2005134741A JP2006312589A JP 2006312589 A JP2006312589 A JP 2006312589A JP 2005134741 A JP2005134741 A JP 2005134741A JP 2005134741 A JP2005134741 A JP 2005134741A JP 2006312589 A JP2006312589 A JP 2006312589A
- Authority
- JP
- Japan
- Prior art keywords
- dehydroabietic acid
- composition
- acid
- sodium
- oral cavity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 51
- 210000000214 mouth Anatomy 0.000 title claims abstract description 14
- QUUCYKKMFLJLFS-UHFFFAOYSA-N Dehydroabietan Natural products CC1(C)CCCC2(C)C3=CC=C(C(C)C)C=C3CCC21 QUUCYKKMFLJLFS-UHFFFAOYSA-N 0.000 claims abstract description 46
- NFWKVWVWBFBAOV-UHFFFAOYSA-N Dehydroabietic acid Natural products OC(=O)C1(C)CCCC2(C)C3=CC=C(C(C)C)C=C3CCC21 NFWKVWVWBFBAOV-UHFFFAOYSA-N 0.000 claims abstract description 46
- NFWKVWVWBFBAOV-MISYRCLQSA-N dehydroabietic acid Chemical compound OC(=O)[C@]1(C)CCC[C@]2(C)C3=CC=C(C(C)C)C=C3CC[C@H]21 NFWKVWVWBFBAOV-MISYRCLQSA-N 0.000 claims abstract description 46
- 229940118781 dehydroabietic acid Drugs 0.000 claims abstract description 46
- RSWGJHLUYNHPMX-UHFFFAOYSA-N Abietic-Saeure Natural products C12CCC(C(C)C)=CC2=CCC2C1(C)CCCC2(C)C(O)=O RSWGJHLUYNHPMX-UHFFFAOYSA-N 0.000 claims abstract description 17
- KHPCPRHQVVSZAH-HUOMCSJISA-N Rosin Natural products O(C/C=C/c1ccccc1)[C@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 KHPCPRHQVVSZAH-HUOMCSJISA-N 0.000 claims abstract description 17
- KHPCPRHQVVSZAH-UHFFFAOYSA-N trans-cinnamyl beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OCC=CC1=CC=CC=C1 KHPCPRHQVVSZAH-UHFFFAOYSA-N 0.000 claims abstract description 17
- 208000028169 periodontal disease Diseases 0.000 claims abstract description 12
- 150000003242 quaternary ammonium salts Chemical class 0.000 claims abstract description 10
- 239000000463 material Substances 0.000 claims abstract description 7
- 238000011282 treatment Methods 0.000 claims abstract description 6
- 229960001927 cetylpyridinium chloride Drugs 0.000 claims description 12
- YMKDRGPMQRFJGP-UHFFFAOYSA-M cetylpyridinium chloride Chemical group [Cl-].CCCCCCCCCCCCCCCC[N+]1=CC=CC=C1 YMKDRGPMQRFJGP-UHFFFAOYSA-M 0.000 claims description 12
- 230000002265 prevention Effects 0.000 claims description 5
- 238000011321 prophylaxis Methods 0.000 abstract 1
- -1 fatty acid esters Chemical class 0.000 description 40
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 22
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerol Natural products OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 22
- 235000014113 dietary fatty acids Nutrition 0.000 description 17
- 239000000194 fatty acid Substances 0.000 description 17
- 229930195729 fatty acid Natural products 0.000 description 17
- 102000005741 Metalloproteases Human genes 0.000 description 15
- 108010006035 Metalloproteases Proteins 0.000 description 15
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 15
- 239000011159 matrix material Substances 0.000 description 15
- 235000011187 glycerol Nutrition 0.000 description 12
- 230000000694 effects Effects 0.000 description 11
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 10
- 239000004615 ingredient Substances 0.000 description 10
- 239000008213 purified water Substances 0.000 description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 10
- 239000002324 mouth wash Substances 0.000 description 8
- 229940051866 mouthwash Drugs 0.000 description 8
- RUVINXPYWBROJD-ONEGZZNKSA-N trans-anethole Chemical compound COC1=CC=C(\C=C\C)C=C1 RUVINXPYWBROJD-ONEGZZNKSA-N 0.000 description 8
- 238000013329 compounding Methods 0.000 description 7
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 6
- 210000001519 tissue Anatomy 0.000 description 6
- FTLYMKDSHNWQKD-UHFFFAOYSA-N (2,4,5-trichlorophenyl)boronic acid Chemical compound OB(O)C1=CC(Cl)=C(Cl)C=C1Cl FTLYMKDSHNWQKD-UHFFFAOYSA-N 0.000 description 5
- 239000002202 Polyethylene glycol Substances 0.000 description 5
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 5
- 239000011230 binding agent Substances 0.000 description 5
- 239000004359 castor oil Substances 0.000 description 5
- 235000019438 castor oil Nutrition 0.000 description 5
- 239000003205 fragrance Substances 0.000 description 5
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 5
- 230000002401 inhibitory effect Effects 0.000 description 5
- 238000004519 manufacturing process Methods 0.000 description 5
- OSWPMRLSEDHDFF-UHFFFAOYSA-N methyl salicylate Chemical compound COC(=O)C1=CC=CC=C1O OSWPMRLSEDHDFF-UHFFFAOYSA-N 0.000 description 5
- 229920001223 polyethylene glycol Polymers 0.000 description 5
- 229940085605 saccharin sodium Drugs 0.000 description 5
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 5
- 229940034610 toothpaste Drugs 0.000 description 5
- 239000000606 toothpaste Substances 0.000 description 5
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 4
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 4
- 102000010834 Extracellular Matrix Proteins Human genes 0.000 description 4
- 108010037362 Extracellular Matrix Proteins Proteins 0.000 description 4
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 4
- 229940011037 anethole Drugs 0.000 description 4
- 229960003237 betaine Drugs 0.000 description 4
- 150000004287 bisbiguanides Chemical class 0.000 description 4
- FUFJGUQYACFECW-UHFFFAOYSA-L calcium hydrogenphosphate Chemical compound [Ca+2].OP([O-])([O-])=O FUFJGUQYACFECW-UHFFFAOYSA-L 0.000 description 4
- 239000001506 calcium phosphate Substances 0.000 description 4
- 239000001768 carboxy methyl cellulose Substances 0.000 description 4
- 210000002744 extracellular matrix Anatomy 0.000 description 4
- 239000000417 fungicide Substances 0.000 description 4
- 238000002156 mixing Methods 0.000 description 4
- RUVINXPYWBROJD-UHFFFAOYSA-N para-methoxyphenyl Natural products COC1=CC=C(C=CC)C=C1 RUVINXPYWBROJD-UHFFFAOYSA-N 0.000 description 4
- 201000001245 periodontitis Diseases 0.000 description 4
- 239000011734 sodium Substances 0.000 description 4
- 229910052708 sodium Inorganic materials 0.000 description 4
- 239000001509 sodium citrate Substances 0.000 description 4
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 description 4
- 239000000600 sorbitol Substances 0.000 description 4
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 3
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 235000019739 Dicalciumphosphate Nutrition 0.000 description 3
- 102000004190 Enzymes Human genes 0.000 description 3
- 108090000790 Enzymes Proteins 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 3
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 description 3
- 239000004373 Pullulan Substances 0.000 description 3
- 229920001218 Pullulan Polymers 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- 230000000844 anti-bacterial effect Effects 0.000 description 3
- 239000003899 bactericide agent Substances 0.000 description 3
- UREZNYTWGJKWBI-UHFFFAOYSA-M benzethonium chloride Chemical compound [Cl-].C1=CC(C(C)(C)CC(C)(C)C)=CC=C1OCCOCC[N+](C)(C)CC1=CC=CC=C1 UREZNYTWGJKWBI-UHFFFAOYSA-M 0.000 description 3
- 229960001950 benzethonium chloride Drugs 0.000 description 3
- 235000010418 carrageenan Nutrition 0.000 description 3
- 239000000679 carrageenan Substances 0.000 description 3
- 229920001525 carrageenan Polymers 0.000 description 3
- 229940113118 carrageenan Drugs 0.000 description 3
- 125000002091 cationic group Chemical group 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 3
- 229910000390 dicalcium phosphate Inorganic materials 0.000 description 3
- 229940038472 dicalcium phosphate Drugs 0.000 description 3
- REZZEXDLIUJMMS-UHFFFAOYSA-M dimethyldioctadecylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)CCCCCCCCCCCCCCCCCC REZZEXDLIUJMMS-UHFFFAOYSA-M 0.000 description 3
- 239000004664 distearyldimethylammonium chloride (DHTDMAC) Substances 0.000 description 3
- 229940088598 enzyme Drugs 0.000 description 3
- 210000002919 epithelial cell Anatomy 0.000 description 3
- 235000010445 lecithin Nutrition 0.000 description 3
- 239000000787 lecithin Substances 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
- 229930014626 natural product Natural products 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- 230000003239 periodontal effect Effects 0.000 description 3
- 235000019423 pullulan Nutrition 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- SERLAGPUMNYUCK-DCUALPFSSA-N 1-O-alpha-D-glucopyranosyl-D-mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O SERLAGPUMNYUCK-DCUALPFSSA-N 0.000 description 2
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 description 2
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- XGRSAFKZAGGXJV-UHFFFAOYSA-N 3-azaniumyl-3-cyclohexylpropanoate Chemical compound OC(=O)CC(N)C1CCCCC1 XGRSAFKZAGGXJV-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
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- 229920001661 Chitosan Polymers 0.000 description 2
- WJLVQTJZDCGNJN-UHFFFAOYSA-N Chlorhexidine hydrochloride Chemical compound Cl.Cl.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WJLVQTJZDCGNJN-UHFFFAOYSA-N 0.000 description 2
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- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 description 2
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- WEEGYLXZBRQIMU-UHFFFAOYSA-N Eucalyptol Chemical compound C1CC2CCC1(C)OC2(C)C WEEGYLXZBRQIMU-UHFFFAOYSA-N 0.000 description 2
- 108010026132 Gelatinases Proteins 0.000 description 2
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- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 2
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- AOMUHOFOVNGZAN-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)dodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CCO)CCO AOMUHOFOVNGZAN-UHFFFAOYSA-N 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
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- VBIIFPGSPJYLRR-UHFFFAOYSA-M Stearyltrimethylammonium chloride Chemical compound [Cl-].CCCCCCCCCCCCCCCCCC[N+](C)(C)C VBIIFPGSPJYLRR-UHFFFAOYSA-M 0.000 description 2
- MSCCTZZBYHQMQJ-AZAGJHQNSA-N Tocopheryl nicotinate Chemical compound C([C@@](OC1=C(C)C=2C)(C)CCC[C@H](C)CCC[C@H](C)CCCC(C)C)CC1=C(C)C=2OC(=O)C1=CC=CN=C1 MSCCTZZBYHQMQJ-AZAGJHQNSA-N 0.000 description 2
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- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 2
- 150000001298 alcohols Chemical class 0.000 description 2
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- ISWSIDIOOBJBQZ-UHFFFAOYSA-N phenol group Chemical group C1(=CC=CC=C1)O ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 2
- 235000013824 polyphenols Nutrition 0.000 description 2
- NROKBHXJSPEDAR-UHFFFAOYSA-M potassium fluoride Chemical compound [F-].[K+] NROKBHXJSPEDAR-UHFFFAOYSA-M 0.000 description 2
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- 150000003839 salts Chemical class 0.000 description 2
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 2
- 239000000741 silica gel Substances 0.000 description 2
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Abstract
Description
本発明は、口腔用組成物に関する。さらに詳しくは、デヒドロアビエチン酸と第四級アンモニウム塩からなる口腔用組成物に関する。 The present invention relates to an oral composition. More specifically, the present invention relates to an oral composition comprising dehydroabietic acid and a quaternary ammonium salt.
マトリックスメタロプロテアーゼ（ＭＭＰ）は、細胞外マトリックスを分解する金属酵素の総称である。細胞外マトリックスは、哺乳動物の組織において細胞間のすきまを埋めている生体高分子であり、コラーゲンやプロテオグリカン、エラスチンなどを成分とする。この細胞外マトリックスの代謝は、マトリックスメタロプロテアーゼと、マトリックスメタロプロテアーゼに特異的な組織由来メタロプロテアーゼインヒビター（ＴＩＭＰ）とのバランスにより、主に調節されている。細胞外マトリックス成分の構造異常や、合成・分解の代謝バランスの崩れは、変形性関節症や慢性関節リウマチ等の関節疾患や癌の浸潤・転移と関連し、歯周病においても、病態の進行と種々のマトリックスメタロプロテアーゼ活性の上昇は関連していることが知られている。 Matrix metalloprotease (MMP) is a general term for metalloenzymes that degrade extracellular matrix. The extracellular matrix is a biopolymer that fills gaps between cells in mammalian tissue, and contains collagen, proteoglycan, elastin, and the like as components. The metabolism of this extracellular matrix is mainly regulated by the balance between matrix metalloprotease and tissue-derived metalloprotease inhibitor (TIMP) specific to matrix metalloprotease. Abnormal structure of extracellular matrix components and disruption of synthesis / degradation metabolic balance are associated with joint diseases such as osteoarthritis and rheumatoid arthritis, as well as cancer invasion and metastasis. And increased matrix metalloprotease activity are known to be related.
マトリックスメタロプロテアーゼとしては、コラゲナーゼ（ＭＭＰ-１および８）、ストロメライシン（ＭＭＰ-３）、ゼラチナーゼ（ＭＭＰ-２および９）など１０種類以上の酵素分子種が知られ（吉原, 新名：炎症と免疫，2，177-185，1994）、これらは多種の細胞によって産生される。コラゲナーゼは通常上皮系の細胞からは産生されないが、歯周組織においては付着上皮およびポケット上皮周辺においてしばしば発現が認められている（M．Kylmaniemi et al： J．Dent Res．，75：919-926，1996）。また、基底膜の構成成分であるＩＶ型コラーゲンを分解するゼラチナーゼは、歯周病原因菌由来のリポ多糖等の因子の刺激により上皮細胞から産生されることが報告されており、これらのことから、マトリックスメタロプロテアーゼは、歯周病の進行と深く関っていると考えられる。 As matrix metalloproteases, more than 10 types of enzyme molecules such as collagenase (MMP-1 and 8), stromelysin (MMP-3), gelatinase (MMP-2 and 9) are known (Yoshihara, new name: inflammation) And immunization, 2, 177-185, 1994), these are produced by a variety of cells. Collagenase is usually not produced from epithelial cells, but in periodontal tissues it is frequently expressed around the adherent and pocket epithelium (M. Kylmaniemi et al: J. Dent Res., 75: 919-926). 1996). In addition, it has been reported that gelatinase that degrades type IV collagen, which is a component of the basement membrane, is produced from epithelial cells by stimulation of factors such as lipopolysaccharide derived from periodontal disease-causing bacteria. Matrix metalloproteinases are thought to be deeply involved in the progression of periodontal disease.
さらに、歯周病患者の口腔洗浄液、歯肉溝滲出液および唾液中のマトリックスメタロプロテアーゼ量は、患者の病態を反映し、治療行為によりマトリックスメタロプロテアーゼ量が減少することが報告されている（M.．Makela et al：J．Dent Res．，73：1397−1406，1994）。また、マトリックスメタロプロテアーゼとＴＩＭＰの量を健常者と比較した場合、歯肉炎患者においてかなり高く、歯周炎患者はさらに高かったことが報告されている（A．Haerian et al：J．Clin Periodontol．，22：505-509，1995）。これまでに、テトラサイクリンおよびこの修飾体が、線維芽細胞と上皮細胞のマトリックスメタロプロテアーゼ活性を阻害することが報告されている（L．H．Nip et al：J．Periodont Res．，28：379-385，1993）。また、マトリックスメタロプロテアーゼに対する阻害剤として、多数のヒドロキサム酸誘導体（特表平７−５０５３８７号公報、特開平０８−８１４４３号公報）、エスクレチン誘導体（特開平０８−１８３７８５号公報）等が合成され、天然物を由来とするフラボン類またはアントシアニジン類を有効成分とするものも報告されている（特開平０８−１０４６２８号公報）。 In addition, the amount of matrix metalloprotease in oral irrigation fluid, gingival crevicular fluid and saliva of periodontal disease patients has been reported to reflect the patient's pathology, and the amount of matrix metalloprotease decreases with treatment (M. Makela et al: J. Dent Res., 73: 1397-1406, 1994). It has also been reported that when the amounts of matrix metalloprotease and TIMP are compared with those in healthy subjects, it is considerably higher in patients with gingivitis and higher in patients with periodontitis (A. Haerian et al: J. Clin Periodontol. 22: 505-509, 1995). To date, tetracycline and its modifications have been reported to inhibit matrix metalloprotease activity in fibroblasts and epithelial cells (L. H. Nip et al: J. Periodont Res., 28: 379-). 385, 1993). In addition, as inhibitors for matrix metalloproteases, a number of hydroxamic acid derivatives (Japanese Patent Publication No. 7-505387, Japanese Patent Laid-Open No. 08-81443), esculetin derivatives (Japanese Patent Laid-Open No. 08-183785) and the like are synthesized. A substance containing a flavone or anthocyanidins derived from a natural product as an active ingredient has also been reported (Japanese Patent Laid-Open No. 08-104628).
また、天然物由来のキノン、三環式ジテルペンおよび五環式トリテルペンが、マトリックスメタロプロテアーゼ活性に対する阻害効果、および／または、細胞のマトリックスメタロプロテアーゼ産生に対する阻害効果を有するとの報告がある。（特開平１１−１３９９４７号公報）
近年、ロジン由来のデヒドロアビエチン酸がマトリックスメタロプロテアーゼ活性阻害を有することが報告された（二宮、武村、永田：the Quintessence, Vol.22 No.9: 41-47, 2003）。なお、デヒドロアビエチン酸はこれまでにテルペノイド及びフラボノイドを含む口腔用組成物（特表２００４−５２１８８０号公報）、ロジン及びロジン加工物質を配合する歯周病菌増殖抑制剤（特開平０４−６６５２３号公報）、イソチペンチジル類含有組成物（特開昭６３−６３６１４号公報）において口腔用組成物に配合されることが報告されている。しかしながら、デヒドロアビエチン酸を配合した口腔用組成物は、製剤化、歯周病予防効果の面で問題点があり、上記の報告においても改善するべき課題があった。
In addition, it has been reported that quinones derived from natural products, tricyclic diterpenes and pentacyclic triterpenes have an inhibitory effect on matrix metalloprotease activity and / or an inhibitory effect on cellular matrix metalloprotease production. (JP-A-11-139947)
Recently, rosin-derived dehydroabietic acid has been reported to have matrix metalloprotease activity inhibition (Ninomiya, Takemura, Nagata: the Quintessence, Vol.22 No.9: 41-47, 2003). In addition, dehydroabietic acid is an oral composition containing terpenoids and flavonoids (Japanese Patent Publication No. 2004-521880), a periodontal pathogen growth inhibitor containing rosin and a processed rosin (JP-A 04-66523). ) And isothipentidyl-containing compositions (Japanese Patent Laid-Open No. 63-63614), it is reported that they are blended into oral compositions. However, the oral composition containing dehydroabietic acid has problems in terms of formulation and periodontal disease prevention effect, and there is a problem to be improved in the above report.
本発明の目的は、上記問題を解決したデヒドロアビエチン酸を配合した口腔用組成物を提供することにある。 The objective of this invention is providing the composition for oral cavity which mix | blended dehydroabietic acid which solved the said problem.
上記目的を達成するため、本発明者らは、鋭意研究を重ねた結果、デヒドロアビエチン酸を配合してなる口腔用組成物に第四級アンモニウム塩を配合することにより、製剤化、歯周病予防効果の面での問題点が改善することを見出し、本発明を完成するに至った。すなわち、本発明は、以下の口腔用組成物を提供するものである。
項１ デヒドロアビエチン酸、デヒドロアビエチン酸含有物から選ばれる１種以上と第四級アンモニウム塩を含有してなる口腔用組成物。
項２ 第４級アンモニウム塩が塩化セチルピリジニウムである項１に記載の口腔用組成物。
項３ デヒドロアビエチン酸含有物がデヒドロアビエチン酸を４０％以上含有するデヒドロアビエチン酸高含有不均化ロジンである項１、２の何れか１項に記載の口腔用組成物。
項４ デヒドロアビエチン酸含有物がデヒドロアビエチン酸を５５％以上含有するデヒドロアビエチン酸高含有不均化ロジンである項１、２の何れか１項に記載の口腔用組成物。
項５ 口腔用組成物が歯周疾患予防、あるいは治療用である項１、２、３及び４の何れか１項に記載の口腔用組成物。
In order to achieve the above-mentioned object, the present inventors have conducted intensive research, and as a result, formulated a quaternary ammonium salt into a composition for oral cavity containing dehydroabietic acid. The present inventors have found that the problem in terms of preventive effect is improved and have completed the present invention. That is, the present invention provides the following oral composition.
Item 1 An oral composition comprising one or more selected from dehydroabietic acid and dehydroabietic acid-containing substances and a quaternary ammonium salt.
Item 2. The oral composition according to Item 1, wherein the quaternary ammonium salt is cetylpyridinium chloride.
Item 3. The oral composition according to any one of Items 1 and 2, wherein the dehydroabietic acid-containing material is a dehydroabietic acid-rich disproportionated rosin containing 40% or more of dehydroabietic acid.
Item 4. The oral composition according to any one of Items 1 and 2, wherein the dehydroabietic acid-containing material is a dehydroabietic acid-rich disproportionated rosin containing 55% or more of dehydroabietic acid.
Item 5. The oral composition according to any one of Items 1, 2, 3, and 4, wherein the oral composition is used for the prevention or treatment of periodontal diseases.
本発明の口腔用組成物においてデヒドロアビエチン酸の製剤化、歯周病予防効果の面での問題点が改善しており、実使用において好ましく使用できる。また、本発明の口腔用組成物はデヒドロアビエチン酸高含有物の配合により歯周疾患予防あるいは治療の効果が期待できる In the composition for oral cavity of the present invention, the problems of formulation of dehydroabietic acid and prevention of periodontal disease have been improved, and it can be preferably used in actual use. In addition, the composition for oral cavity of the present invention can be expected to have an effect of preventing or treating periodontal diseases by blending a high content of dehydroabietic acid.
以下に、本発明を詳細に説明する。
本発明に用いるデヒドロアビエチン酸、デヒドロアビエチン酸含有物は、特に限られるものではなく、合成品あるいは天然物由来品として得られ、主として松に含まれる樹脂から製造され商業的に入手できるデヒドロアビエチン酸あるいは不均化ロジンであり、中でもデヒドロアビエチン酸を４０％以上含有するデヒドロアビエチン酸高含有不均化ロジンが好ましく、特にデヒドロアビエチン酸を５５％以上含有するデヒドロアビエチン酸高含有不均化ロジンが好ましい。これらは、例えばＫＲ６１４、ロンジスＲ（荒川化学株式会社製）、G-１００Ｆ（ハリマ化成株式会社製）などとして商業的に入手できる。
The present invention is described in detail below.
The dehydroabietic acid and dehydroabietic acid-containing product used in the present invention are not particularly limited, and are obtained as a synthetic product or a natural product-derived product, and are mainly produced from a resin contained in pine and are commercially available. Alternatively, it is a disproportionated rosin, and in particular, a dehydroabietic acid-rich disproportionated rosin containing 40% or more of dehydroabietic acid is preferable, and a dehydroabietic acid-containing disproportionated rosin containing 55% or more of dehydroabietic acid is particularly preferable. preferable. These are commercially available, for example, as KR614, Longis R (Arakawa Chemical Co., Ltd.), G-100F (Harima Kasei Co., Ltd.), and the like.
本発明におけるデヒドロアビエチン酸、デヒドロアビエチン酸含有物の配合量は組成物全量に対して０．００１〜２０重量％であり、特に０．０１〜１０重量％が好ましい。配合量が０．００１重量％に満たないときは、十分な効果が得られず、２０重量％を超えると口腔用組成物として製剤化が困難となる。 The compounding quantity of the dehydroabietic acid and the dehydroabietic acid containing material in this invention is 0.001-20 weight% with respect to the composition whole quantity, and 0.01-10 weight% is especially preferable. When the blending amount is less than 0.001% by weight, a sufficient effect cannot be obtained, and when it exceeds 20% by weight, it becomes difficult to formulate as an oral composition.
本発明に用いる第四級アンモニウム塩は特に限定されるものではなく、例えば塩化セチルピリジニウム、塩化ベンゼトニウム、塩化ジステアリルジメチルアンモニウム、塩化ステアリルジメチルベンジルアンモニウム、塩化ステアリルトリメチルアンモニウム、塩化セチルトリメチルアンモニウム、塩化ラウリルトリメチルアンモニウム、塩化ラウリルピリジニウム、塩化ベンザルコニウム等があげられるが、特に塩化セチルピリジニウムが好ましい。 The quaternary ammonium salt used in the present invention is not particularly limited. For example, cetylpyridinium chloride, benzethonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, cetyltrimethylammonium chloride, lauryl chloride. Examples thereof include trimethylammonium, laurylpyridinium chloride, and benzalkonium chloride, and cetylpyridinium chloride is particularly preferable.
本発明における第四級アンモニウム塩の配合量は０．００１〜３０重量％であり、特に０．０１〜５．０が好ましい。配合量が０．００１重量％に満たないときは、目的を達成するための十分な効果が得られず、３０重量％を越えると香味の面から好ましくない。
また、本発明では、特にデヒドロアビエチン酸と第四級アンモニウム塩の重量比が５０：１〜１：５０の範囲が好ましい。
The compounding quantity of the quaternary ammonium salt in this invention is 0.001-30 weight%, and 0.01-5.0 is especially preferable. When the blending amount is less than 0.001% by weight, a sufficient effect for achieving the object cannot be obtained, and when it exceeds 30% by weight, it is not preferable from the aspect of flavor.
In the present invention, the weight ratio of dehydroabietic acid and quaternary ammonium salt is particularly preferably in the range of 50: 1 to 1:50.
本発明のデヒドロアビエチン酸は、マトリックスメタロプロテアーゼの活性阻害効果が知られており、該阻害効果は歯周病等に罹患した歯周組織細胞が産生したマトリックスメタロプロテアーゼが、組織間の細胞外マトリックスを分解し、組織の破壊を増悪させるのを阻害するものである。マトリックスメタロプロテアーゼの産生阻害効果は、歯周炎、歯肉炎、歯根膜炎、智歯周囲炎、インプラント周囲炎等の歯周疾患等の症状、疾患の予防、治療に有効とされている。従って、本発明の口腔用組成物は、歯周病の予防及び治療に好適である。 The dehydroabietic acid of the present invention is known to have an inhibitory effect on the activity of matrix metalloprotease, and this inhibitory effect is caused by the matrix metalloprotease produced by periodontal tissue cells affected by periodontal disease, etc. It inhibits the degradation of tissue and exacerbates tissue destruction. The production inhibitory effect of matrix metalloproteinase is effective for the prevention and treatment of symptoms such as periodontitis, gingivitis, periodontitis, periodontitis, periodontal disease such as peri-implantitis, and the like. Therefore, the composition for oral cavity of the present invention is suitable for prevention and treatment of periodontal disease.
本発明の口腔用組成物は、その形態に応じて種々の公知成分を配合し、練歯磨、液体歯磨、洗口剤、口腔用ゲル剤等として提供でき、特に洗口剤が最適の形態である。これらの口腔用組成物の形態にあっては、通常の製造方法によって製造することができ、特に洗口剤にあっては高エネルギー下で製造する方法も有効とされる。 The oral composition of the present invention can be provided as a toothpaste, a liquid toothpaste, a mouthwash, a mouth gel, etc., particularly in the optimal form of a mouthwash, depending on its form. is there. In the form of these oral compositions, it can be produced by a normal production method, and in particular for a mouthwash, a production method under high energy is also effective.
本発明では上記必須の成分以外にそれぞれの形態に応じ、その他の成分、例えば殺菌剤、界面活性剤、研磨剤、湿潤剤、１価アルコール、粘結剤、香料、甘味剤、ｐＨ調整剤、防腐剤、色素等を、本発明の効果を損なわない範囲で適宜配合することができる。
界面活性剤としてアニオン性、カチオン性、ノニオン性及び両性界面活性剤を単独または２種以上を組合わせて配合することができ、ノニオン性界面活性剤は、特に限定されるものではなく、口腔用組成物に用いられるショ糖脂肪酸エステルやマルトース脂肪酸エステルなどの糖脂肪酸エステル、マルチトール脂肪酸エステル等の糖アルコール脂肪酸エステル、モノラウリン酸ソルビタン等のソルビタン脂肪酸エステル、ポリオキシエチレンソルビタンモノラウレートやポリオキシエチレンソルビタンモノステアレート等のポリオキシエチレンソルビタン脂肪酸エステル、ラウリン酸ジエタノールアミドのような脂肪酸アルカノールアミド、ポリオキシエチレンステアリルエーテル、ポリオキシエチレンオレイルエーテル等のポリオキシエチレンアルキルエーテル、モノオレイン酸ポリエチレングリコール、モノラウリン酸ポリエチレングリコール等のポリエチレングリコール脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレン脂肪酸エステル、アルキルグルコシド類、ポリオキシエチレン硬化ヒマシ油、グリセリン脂肪酸エステル、ポリオキシエチレンプロピレンブロックコポリマーなどが挙げられる。アニオン性界面活性剤としてはラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウムなどのアルキル硫酸ナトリウム、Ｎ−ラウロイルザルコシン酸ナトリウム、Ｎ−ミリストイルザルコシン酸ナトリウムなどのＮ−アシルザルコシン酸ナトリウム、Ｎ−パルミトイルグルタミン酸ナトリウムなどのＮ−アシルグルタミン酸塩、ポリオキシエチレンアルキル（Ｃ12〜Ｃ14）スルホコハク酸２ナトリウムなどが挙げられる。両性界面活性剤としては、アミノ酸型、アルキルベタイン型、アルキルアミドベタイン型、スルホベタイン型、イミダゾリン型等であり、好ましくは２−アルキル−Ｎ−カルボキシメチル−Ｎ−ヒドロキシエチルイミダゾリニウムベタインまたはヤシ油脂肪酸アミドプロピルベタインなどが挙げられる。これらの配合量は通常、組成物全量に対して０．０５〜３０重量％であり、特に０．１％〜５％重量％が好ましい。
In the present invention, in addition to the essential components described above, other components such as bactericides, surfactants, abrasives, wetting agents, monohydric alcohols, binders, fragrances, sweeteners, pH adjusters, Preservatives, pigments and the like can be appropriately blended within a range that does not impair the effects of the present invention.
As the surfactant, anionic, cationic, nonionic and amphoteric surfactants can be blended alone or in combination of two or more. The nonionic surfactant is not particularly limited and is used for oral use. Sugar fatty acid esters such as sucrose fatty acid esters and maltose fatty acid esters used in the composition, sugar alcohol fatty acid esters such as maltitol fatty acid esters, sorbitan fatty acid esters such as sorbitan monolaurate, polyoxyethylene sorbitan monolaurate and polyoxyethylene Polyoxyethylene such as polyoxyethylene sorbitan fatty acid ester such as sorbitan monostearate, fatty acid alkanolamide such as lauric acid diethanolamide, polyoxyethylene stearyl ether, polyoxyethylene oleyl ether Alkyl ether, polyethylene glycol monooleate, polyethylene glycol monolaurate, polyethylene glycol fatty acid ester, polyglycerin fatty acid ester, polyoxyethylene glycerin fatty acid ester, polyoxyethylene fatty acid ester, alkyl glucosides, polyoxyethylene hydrogenated castor oil, Examples include glycerin fatty acid ester and polyoxyethylene propylene block copolymer. Examples of anionic surfactants include sodium alkyl sulfates such as sodium lauryl sulfate and sodium myristyl sulfate, sodium N-acyl sarcosine such as sodium N-lauroyl sarcosine, sodium N-myristoyl sarcinate, and sodium N-palmitoyl glutamate. N- acyl glutamates, polyoxyethylene alkyl (C 12 ~C 14), such as sulfosuccinate disodium and the like. Examples of the amphoteric surfactant include amino acid type, alkyl betaine type, alkylamido betaine type, sulfobetaine type, imidazoline type, etc., preferably 2-alkyl-N-carboxymethyl-N-hydroxyethyl imidazolinium betaine or palm And oil fatty acid amidopropyl betaine. These compounding amounts are usually 0.05 to 30% by weight, particularly 0.1% to 5% by weight, based on the total amount of the composition.
研磨剤として、炭酸カルシウム、リン酸カルシウム、第２リン酸カルシウム、ピロリン酸カルシウム、不溶性メタリン酸ナトリウム、酸化チタン、非晶質シリカ、結晶質シリカ、アルミノシリケート、酸化アルミニウム、水酸化アルミニウム、レジンなどを、単独または２種以上を組合わせて配合することができる。これらの配合量は、通常、組成物全量に対して１０〜６０重量％である。 As an abrasive, calcium carbonate, calcium phosphate, dicalcium phosphate, calcium pyrophosphate, insoluble sodium metaphosphate, titanium oxide, amorphous silica, crystalline silica, aluminosilicate, aluminum oxide, aluminum hydroxide, resin, etc. alone or 2 It can mix | blend combining a seed | species or more. These compounding quantities are 10-60 weight% normally with respect to the composition whole quantity.
湿潤剤としては、例えば、グリセリン、ソルビトール、ポリエチレングリコール、プロピレングリコール、エチレングリコール、ヘキシレングリコール、１，３−ブチレングリコール、ポリプロピレングリコール、キシリトール、マルチトール、ラクチトールなどの多価アルコールを、単独または２種以上を組み合わせて配合することができ、その配合量は、通常、組成物全体に対して３〜２０重量％である。 As the wetting agent, for example, polyhydric alcohols such as glycerin, sorbitol, polyethylene glycol, propylene glycol, ethylene glycol, hexylene glycol, 1,3-butylene glycol, polypropylene glycol, xylitol, maltitol, and lactitol may be used alone or in combination. It can mix | blend combining a seed | species or more, The compounding quantity is 3 to 20 weight% normally with respect to the whole composition.
１価アルコールとしては、例えば、エタノール、プロピルアルコール、イソプロピルアルコールなどが挙げられ、特にエタノールが好ましい。これら１価アルコールは単独または２種以上を組み合わせて配合することができ、その配合量は、通常、組成物全体に対して０〜１５重量％である。 Examples of the monohydric alcohol include ethanol, propyl alcohol, and isopropyl alcohol, and ethanol is particularly preferable. These monohydric alcohols can be blended singly or in combination of two or more, and the blending amount is usually 0 to 15% by weight with respect to the whole composition.
粘結剤としては、例えば、カラギーナン、カルボキシメチルセルロース等のセルロース誘導体、アルギン酸ナトリウム等のアルカリ金属アルギネート、キサンタンガム、トラガカントガム、アラビアガム等のガム類、ポリビニルアルコール、ポリアクリル酸ナトリウム等の合成粘結剤、シリカゲル、アルミニウムシリカゲル、ビーガム等の無機粘結剤などが挙げられ、これら粘結剤の配合量は、通常、組成物全量に対して０．０１〜５重量％である。 Examples of the binder include cellulose derivatives such as carrageenan and carboxymethyl cellulose, alkali metal alginates such as sodium alginate, gums such as xanthan gum, tragacanth gum and gum arabic, and synthetic binders such as polyvinyl alcohol and sodium polyacrylate. Examples thereof include inorganic binders such as silica gel, aluminum silica gel, and bee gum. The amount of these binders is usually 0.01 to 5% by weight based on the total amount of the composition.
香味剤としては、例えば、アネトール、メントール、ペパーミント油、スペアミント油、レモン油、オレンジ油、セージ油、ローズマリー油、珪皮油、シソ油、冬緑油、丁子油、ユーカリ油、ピメント油、カルボン、シンナミックアルデヒド、シネオール、メントン、リモネン、サリチル酸メチルなどを本発明の効果を損なわない範囲で、単独または２種以上を組み合わせて配合することができる。その配合量は通常組成物全量に対して０．０００１〜１．０重量％である。 Examples of flavoring agents include anethole, menthol, peppermint oil, spearmint oil, lemon oil, orange oil, sage oil, rosemary oil, cinnamon oil, perilla oil, winter green oil, clove oil, eucalyptus oil, pimento oil, Carvone, cinnamic aldehyde, cineol, menthone, limonene, methyl salicylate and the like can be blended alone or in combination of two or more thereof within a range not impairing the effects of the present invention. The amount is usually 0.0001 to 1.0% by weight based on the total amount of the composition.
甘味剤としては、例えば、パラチニット、サッカリンナトリウム、アセスルファームカリウム、ステビオサイド、ネオヘスペリジルジヒドロカルコン、グリチルリチン、ペリラルチン、タウマチン、アスパラチルフェニルアラニルメチルエステル、ｐ−メトキシシンナミックアルデヒドなどが挙げられ、これらは単独または２種以上を組み合わせて配合することができる。その配合量は、通常、組成物全体に対して０．０１〜１重量％、好ましくは０．０５〜０．５重量％である。 Examples of the sweetening agent include palatinit, saccharin sodium, acesulfame potassium, stevioside, neohesperidyl dihydrochalcone, glycyrrhizin, perilartine, thaumatin, asparatylphenylalanyl methyl ester, p-methoxycinnamic aldehyde, and the like. Can be blended alone or in combination of two or more. The compounding quantity is 0.01 to 1 weight% normally with respect to the whole composition, Preferably it is 0.05 to 0.5 weight%.
ｐＨ調整剤としては、例えば、クエン酸、リン酸、リンゴ酸、ピロリン酸、乳酸、酒石酸、グリセロリン酸、酢酸、硝酸、またはこれらの化学的に可能な塩や水酸化ナトリウムなどが挙げられ、これらは、組成物のｐＨが５〜９の範囲となるよう、単独または２種以上を組み合わせて配合することができる。その配合量は、通常、組成物全体に対して０．０１〜２重量％である。 Examples of the pH adjuster include citric acid, phosphoric acid, malic acid, pyrophosphoric acid, lactic acid, tartaric acid, glycerophosphoric acid, acetic acid, nitric acid, or a chemically possible salt thereof, sodium hydroxide, and the like. Can be blended alone or in combination of two or more so that the pH of the composition is in the range of 5-9. The compounding quantity is 0.01 to 2 weight% normally with respect to the whole composition.
さらに、本発明の口腔用組成物には、酢酸ｄｌ−α−トコフェロール、コハク酸トコフェロール、またはニコチン酸トコフェロールなどのビタミンＥ類、デキストラナーゼ、アミラーゼ、プロテアーゼ、ムタナーゼ、リゾチーム、溶菌酵素（リテックエンザイム）などの酵素、トラネキサム酸やイプシロンアミノカプロン酸の抗プラスミン剤、アルミニウムクロルヒドロキシルアラントイン、ジヒドロコレステロール、グリチルリチン塩類、グリチルレチン酸、グリセロフォスフェート、クロロフィル、塩化ナトリウム、カロペプタイド、水溶性無機リン酸化合物、フッ化物としてフッ化ナトリウム 、フッ化カリウム、フッ化アンモニウム、フッ化カルシウム、フッ化銅、フッ化亜鉛、フッ化リチウム、フッ化セシウム、フッ化ジルコニウム、フッ化スズ、フッ化水素酸、モノフルオルリン酸ナトリウム、モノフルオルリン酸カリウム、フッ化チタンナトリウム、フッ化チタンカリウム、ヘキシルアミンハイドロフルオライド、ラウリルアミンハイドロフルオライド、グリシンハイドロフルオライド、アラニンハイドロフルオライド、フルオロシラン、フッ化ジアンミン銀などを、単独または２種以上を組み合わせて配合することができる。 Furthermore, the oral composition of the present invention includes vitamin Es such as dl-α-tocopherol acetate, tocopherol succinate, or tocopherol nicotinate, dextranase, amylase, protease, mutanase, lysozyme, lytic enzyme (lytech enzyme). ), Enzymes such as tranexamic acid and epsilon aminocaproic acid, aluminum chlorohydroxyl allantoin, dihydrocholesterol, glycyrrhizin salts, glycyrrhetinic acid, glycerophosphate, chlorophyll, sodium chloride, caropeptide, water-soluble inorganic phosphate compound, fluoride As sodium fluoride, potassium fluoride, ammonium fluoride, calcium fluoride, copper fluoride, zinc fluoride, lithium fluoride, cesium fluoride, zirconium fluoride Tin fluoride, hydrofluoric acid, sodium monofluorophosphate, potassium monofluorophosphate, sodium titanium fluoride, potassium titanium fluoride, hexylamine hydrofluoride, laurylamine hydrofluoride, glycine hydrofluoride, Alanine hydrofluoride, fluorosilane, silver fluorinated diamine, etc. can be blended alone or in combination of two or more.
本発明の口腔用組成物は、これらの成分を混合し、通常の方法に従って製造することができる。さらに殺菌剤としてビスビグアニド系、フェノール系、非カチオン性殺菌剤が配合でき、ビスビグアニド系殺菌剤としてはビスビグアニドヘキサン類、ビスビグアニドプロピルエーテル類、ビスビグアニドキシレン類、ビスビグアニドデカン類、ビスビグアニドドデカン類及びそれらの化学的に許容な塩などが挙げられ、特にビスビグアニドヘキサン類であるグルコン酸クロルヘキシジン、塩酸クロルヘキシジンなどのクロルヘキシジン塩類が好ましい。フェノール系殺菌剤としてはイソプロピルメチルフェノール、ヒノキチオールが挙げられる。非カチオン性殺菌剤としてはトリクロサンが挙げられる。これら殺菌剤の配合量は、０．００１〜０．５重量％であり、特に０．０１〜.０
口腔内粘膜滞留性を向上させるため、ゼラチン、コラーゲン、コンニャクマンナン、プルラン、キトサン、デンプンなどの天然高分子、ポリエチレングリコール、カルボキシビニルポリマーなどの合成高分子、デキストラン、ポリアクリルデキストランなどの多糖類、大豆レシチン、卵黄レシチンなどのレシチン、ポリ乳酸、ポリグリコール酸、アルブミン、シクロデキストリン等から単独または２種以上を組み合わせて配合することができる。
The composition for oral cavity of this invention can mix these components and can manufacture it according to a normal method. In addition, bisbiguanide, phenolic, and non-cationic fungicides can be added as bactericides. Bisbiguanide bactericides include bisbiguanide hexanes, bisbiguanide propyl ethers, bisbiguanide xylenes, bisbiguanide decanes, and bisbiguanides. Examples thereof include dodecanes and chemically acceptable salts thereof, and chlorhexidine salts such as chlorhexidine gluconate and chlorhexidine hydrochloride which are bisbiguanide hexanes are particularly preferable. Examples of phenolic fungicides include isopropylmethylphenol and hinokitiol. An example of a non-cationic fungicide is triclosan. The content of these fungicides is 0.001 to 0.5% by weight, particularly 0.01 to 0.0%.
In order to improve oral mucosal retention, natural polymers such as gelatin, collagen, konjac mannan, pullulan, chitosan, starch, synthetic polymers such as polyethylene glycol and carboxyvinyl polymer, polysaccharides such as dextran and polyacryldextran, It can be blended alone or in combination of two or more from lecithins such as soybean lecithin and egg yolk lecithin, polylactic acid, polyglycolic acid, albumin, cyclodextrin and the like.
以下に実施例により本発明をさらに具体的に説明するが,本発明は下記の実施例に制限されるものではない。また、特に断らない限り［％］は［重量％］である。
実施例１ 洗口液
成分 配合量％
デヒドロアビエチン酸 ０．２
酢酸ｄｌ−α−トコフェロール ０．０５
塩酸クロルヘキシジン ０．０５
エタノール ８．０
パラオキシ安息香酸メチル ０．３
サッカリンナトリウム ０．０５
アネトール ０．１
メントール ０．３
ペパーミント油 ０．５
グリセリン １５．０
ポリオキシエチレン硬化ヒマシ油 １．０
塩化セチルピリジニウム ０．０５
プルラン ０．１
精製水 残量
合計 １００．０
The present invention will be described more specifically with reference to the following examples. However, the present invention is not limited to the following examples. Further, unless otherwise specified, [%] is [% by weight].
Example 1 Mouthwash
Ingredient amount%
Dehydroabietic acid 0.2
Dl-α-tocopherol acetate 0.05
Chlorhexidine hydrochloride 0.05
Ethanol 8.0
Methyl paraoxybenzoate 0.3
Saccharin sodium 0.05
Anethole 0.1
Menthol 0.3
Peppermint oil 0.5
Glycerin 15.0
Polyoxyethylene hydrogenated castor oil 1.0
Cetylpyridinium chloride 0.05
Pullulan 0.1
Purified water remaining
Total 100.0
実施例２ 練歯磨
成分 配合量％
デヒドロアビエチン酸 １．０
塩化セチルピリジニウム ０．１
モノフルオロリン酸ナトリウム １．０
リン酸水素カルシウム ２０．０
ソルビット液 １５．０
グリセリン ２０．０
アルキルグルコシド ２．０
ヒドロキシエチルセルロース １．５
パラオキシ安息香酸エステル ０．５
プロピレングリコール ３．０
サッカリンナトリウム ０．１
ペパーミント ０．３
サリチル酸メチル ０．２
アネトール ０．１
メントール ０．２
シネオール ０．３
塩化ベンゼトニウム ０．１
ラウリル硫酸ナトリウム １．５
キトサン ２．０
精製水 残量
合計 １００．０
Example 2 Toothpaste
Ingredient amount%
Dehydroabietic acid 1.0
Cetylpyridinium chloride 0.1
Sodium monofluorophosphate 1.0
Calcium hydrogen phosphate 20.0
Sorbit liquid 15.0
Glycerin 20.0
Alkyl glucoside 2.0
Hydroxyethyl cellulose 1.5
P-Hydroxybenzoate ester 0.5
Propylene glycol 3.0
Saccharin sodium 0.1
Peppermint 0.3
Methyl salicylate 0.2
Anethole 0.1
Menthol 0.2
Cineol 0.3
Benzethonium chloride 0.1
Sodium lauryl sulfate 1.5
Chitosan 2.0
Purified water remaining
Total 100.0
実施例３ 洗口剤
成分 配合量％
不均化ロジン ０．５
パラチニット １．０
プルロニック ３．０
クエン酸 ０．３
クエン酸ナトリウム ０．５
ステビアエキス ０．３
アネトール ０．３
ペパーミント ０．６
スペアミント ０．０４
エタノール ５．０
ソルビトール １５．０
塩化セチルピリジニウム ０．０２
塩化ベンザルコニウム ０．０３
ポリリジン ０．５
精製水 残量
合計 １００．０
Example 3 Mouthwash
Ingredient amount%
Disproportionated rosin 0.5
Palatinit 1.0
Pluronic 3.0
Citric acid 0.3
Sodium citrate 0.5
Stevia extract 0.3
Anethole 0.3
Peppermint 0.6
Spearmint 0.04
Ethanol 5.0
Sorbitol 15.0
Cetylpyridinium chloride 0.02
Benzalkonium chloride 0.03
Polylysine 0.5
Purified water remaining
Total 100.0
実施例４ 練歯磨
成分 配合量％
第２リン酸カルシウム ２５．０
グリセリン １５．０
ソルビトール １８．０
カルボキシメチルセルロースナトリウム ２．０
ラウリル硫酸ナトリウム １．６
カラギーナン ０．４
サッカリンナトリウム ０．２
香料 １．５
安息香酸ナトリウム ０．５
不均化ロジン ０．０３
塩化セチルピリジニウム ０．０５
グリチルリチン酸ジカリウム ０．１
ショ糖脂肪酸エステル ０．１
塩化ジステアリルジメチルアンモニウム ０．０５
プルラン ２．０
精製水 残量
合計 １００．０
Example 4 Toothpaste
Ingredient amount%
Dicalcium phosphate 25.0
Glycerin 15.0
Sorbitol 18.0
Sodium carboxymethylcellulose 2.0
Sodium lauryl sulfate 1.6
Carrageenan 0.4
Saccharin sodium 0.2
Fragrance 1.5
Sodium benzoate 0.5
Disproportionated rosin 0.03
Cetylpyridinium chloride 0.05
Dipotassium glycyrrhizinate 0.1
Sucrose fatty acid ester 0.1
Distearyldimethylammonium chloride 0.05
Pullulan 2.0
Purified water remaining
Total 100.0
実施例５ 洗口剤
成分 配合量％
エタノール ５．０
グリセリン １０．０
クエン酸 ０．１
クエン酸ナトリウム ０．３
ポリオキシエチレン(６０ＥＯ)硬化ヒマシ油 ５．０
パラオキシ安息香酸メチル ０．３
香料 ０．５
デヒドロアビエチン酸高含有不均化ロジン ３．０
トリクロサン ０．５
塩化ステアリルトリメチルアンモニウム ５．０
塩化セチルピリジニウム ０．０８
レシチン １．０
精製水 残量
合計 １００．０
Example 5 Mouthwash
Ingredient amount%
Ethanol 5.0
Glycerin 10.0
Citric acid 0.1
Sodium citrate 0.3
Polyoxyethylene (60EO) hydrogenated castor oil 5.0
Methyl paraoxybenzoate 0.3
Fragrance 0.5
Dehydroabietic acid-rich disproportionated rosin 3.0
Triclosan 0.5
Stearyltrimethylammonium chloride 5.0
Cetylpyridinium chloride 0.08
Lecithin 1.0
Purified water remaining
Total 100.0
実施例６ 洗口剤
成分 配合量％
エタノール ５．５
トラネキサム酸 ０．１
グリセリン ５．５
クエン酸 ０．０５
クエン酸ナトリウム ０．４
ポリオキシエチレン硬化ヒマシ油 ０．８
パラオキシ安息香酸メチル ０．３
デヒドロアビエチン酸高含有不均化ロジン １．５
シラカバエキス ０．６
グリセリン脂肪酸エステル ０．５
塩化ステアリルジメチルベンジルアンモニウム ０．５
デキストラン １．０
精製水 残量
合計 １００．０
Example 6 Mouthwash
Ingredient amount%
Ethanol 5.5
Tranexamic acid 0.1
Glycerin 5.5
Citric acid 0.05
Sodium citrate 0.4
Polyoxyethylene hydrogenated castor oil 0.8
Methyl paraoxybenzoate 0.3
High content of dehydroabietic acid disproportionated rosin 1.5
Birch extract 0.6
Glycerin fatty acid ester 0.5
Stearyldimethylbenzylammonium chloride 0.5
Dextran 1.0
Purified water remaining
Total 100.0
実施例７ 口腔用パスタ
成分 配合量％
流動パラフィン １１．０
セタノール ９．０
グリセリン ２０．０
ソルビタンモノパルミテート １．０
ポリオキシエチレンソルビタンモノステアレート ４．０
ラウリル硫酸ナトリウム ０．３
塩化ベンゼトニウム ０．２
ニコチン酸トコフェロール １．０
塩化セチルピリジニウム ０．０５
塩化セチルベンゼトニウム ０．１
サリチル酸メチル ０．１５
サッカリン ０．０５
香料 ０．３
ローズマリーエキス ０．３
α−アミリン ０．０８
デヒドロアビエチン酸 ０．５
塩化セチルトリメチルアンモニウム ２．０
レシチン ２．０
精製水 残量
合計 １００．０
Example 7 Oral Pasta
Ingredient amount%
Liquid paraffin 11.0
Cetanol 9.0
Glycerin 20.0
Sorbitan monopalmitate 1.0
Polyoxyethylene sorbitan monostearate 4.0
Sodium lauryl sulfate 0.3
Benzethonium chloride 0.2
Tocopherol nicotinate 1.0
Cetylpyridinium chloride 0.05
Cetylbenzethonium chloride 0.1
Methyl salicylate 0.15
Saccharin 0.05
Fragrance 0.3
Rosemary extract 0.3
α-Amylin 0.08
Dehydroabietic acid 0.5
Cetyltrimethylammonium chloride 2.0
Lecithin 2.0
Purified water remaining
Total 100.0
実施例８ 口腔用パスタ
成分 配合量％
カルボキシメチルセルロース ５．０
グリセリン ２０．０
デヒドロアビエチン酸 １．５
塩化ラウリルトリメチルアンモニウム ２．０
シクロデキストリン ２．０
精製水 残量
合計 １００．０
Example 8 Oral Pasta
Ingredient amount%
Carboxymethylcellulose 5.0
Glycerin 20.0
Dehydroabietic acid 1.5
Lauryltrimethylammonium chloride 2.0
Cyclodextrin 2.0
Purified water remaining
Total 100.0
実施例９ 洗口液
成分 配合量％
エタノール １１．０
グリセリン ７．０
クエン酸 ０．０３
クエン酸ナトリウム ０．２
ポリオキシエチレン（６０ＥＯ）硬化ヒマシ油 ０．７
ラウリン酸ジエタノールアミド １．０
パラオキシ安息香酸メチル ０．３
デヒドロアビエチン酸高含有不均化ロジン １．０
塩化セチルピリジニウム ０．４５
精製水 残量
合計 １００．０
Example 9 Mouthwash
Ingredient amount%
Ethanol 11.0
Glycerin 7.0
Citric acid 0.03
Sodium citrate 0.2
Polyoxyethylene (60EO) hydrogenated castor oil 0.7
Lauric acid diethanolamide 1.0
Methyl paraoxybenzoate 0.3
Dehydroabietic acid-rich disproportionated rosin 1.0
Cetylpyridinium chloride 0.45
Purified water remaining
Total 100.0
実施例１０ 練歯磨
成分 配合量％
第２リン酸カルシウム ２５．０
グリセリン １５．０
ソルビトール １８．０
カルボキシメチルセルロースナトリウム ２．０
ラウリル硫酸ナトリウム １．６
カラギーナン ０．４
サッカリンナトリウム ０．２
香料 １．５
安息香酸ナトリウム ０．５
デヒドロアビエチン酸高含有不均化ロジン ０．０５
塩化セチルピリジニウム ２．０
グリチルリチン酸ジカリウム ０．１
ショ糖脂肪酸エステル ０．１
塩化ジステアリルジメチルアンモニウム ０．０５
精製水 残量
合計 １００．０
Example 10 Toothpaste
Ingredient amount%
Dicalcium phosphate 25.0
Glycerin 15.0
Sorbitol 18.0
Sodium carboxymethylcellulose 2.0
Sodium lauryl sulfate 1.6
Carrageenan 0.4
Saccharin sodium 0.2
Fragrance 1.5
Sodium benzoate 0.5
High content of dehydroabietic acid disproportionated rosin 0.05
Cetylpyridinium chloride 2.0
Dipotassium glycyrrhizinate 0.1
Sucrose fatty acid ester 0.1
Distearyldimethylammonium chloride 0.05
Purified water remaining
Total 100.0
Claims (5)
The composition for oral cavity according to any one of claims 1, 2, 3, and 4, wherein the composition for oral cavity is used for prevention or treatment of periodontal diseases.
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| JP2005134741A JP2006312589A (en) | 2005-05-06 | 2005-05-06 | Composition for oral cavity |
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|---|---|---|---|
| JP2005134741A JP2006312589A (en) | 2005-05-06 | 2005-05-06 | Composition for oral cavity |
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| Publication Number | Publication Date |
|---|---|
| JP2006312589A true JP2006312589A (en) | 2006-11-16 |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010280610A (en) * | 2009-06-04 | 2010-12-16 | Sunstar Inc | Periodontal disease treatment composition |
| JP2012046433A (en) * | 2010-08-25 | 2012-03-08 | Kao Corp | Liquid composition for oral cavity |
| JP2012111732A (en) * | 2010-11-26 | 2012-06-14 | Sunstar Inc | Composition for oral cavity |
| WO2013010709A3 (en) * | 2011-07-21 | 2013-11-07 | Henkel Ag & Co. Kgaa | Alcoholic hair treatment agent comprising poly-l-lysine |
| WO2012167936A3 (en) * | 2011-06-07 | 2013-11-21 | Beiersdorf Ag | ACTIVE INGREDIENT COMBINATIONS OF ε-POLYLYSIN (EPSILON-POLYLYSINE) AND ONE OR MORE TERPENES |
| JP2018512870A (en) * | 2015-04-22 | 2018-05-24 | アナリティコン ディスカバリー ゲーエムベーハー | Preparations containing dehydroabietic acid |
| JP2018537446A (en) * | 2015-12-19 | 2018-12-20 | アナリティコン・ディスカバリー・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Pharmaceutical formulation |
| JP2022092900A (en) * | 2020-12-11 | 2022-06-23 | サンスター株式会社 | Oral composition |
-
2005
- 2005-05-06 JP JP2005134741A patent/JP2006312589A/en not_active Withdrawn
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2010280610A (en) * | 2009-06-04 | 2010-12-16 | Sunstar Inc | Periodontal disease treatment composition |
| JP2012046433A (en) * | 2010-08-25 | 2012-03-08 | Kao Corp | Liquid composition for oral cavity |
| JP2012111732A (en) * | 2010-11-26 | 2012-06-14 | Sunstar Inc | Composition for oral cavity |
| WO2012167936A3 (en) * | 2011-06-07 | 2013-11-21 | Beiersdorf Ag | ACTIVE INGREDIENT COMBINATIONS OF ε-POLYLYSIN (EPSILON-POLYLYSINE) AND ONE OR MORE TERPENES |
| WO2013010709A3 (en) * | 2011-07-21 | 2013-11-07 | Henkel Ag & Co. Kgaa | Alcoholic hair treatment agent comprising poly-l-lysine |
| JP2018512870A (en) * | 2015-04-22 | 2018-05-24 | アナリティコン ディスカバリー ゲーエムベーハー | Preparations containing dehydroabietic acid |
| JP2018537446A (en) * | 2015-12-19 | 2018-12-20 | アナリティコン・ディスカバリー・ゲゼルシャフト・ミト・ベシュレンクテル・ハフツング | Pharmaceutical formulation |
| JP2022092900A (en) * | 2020-12-11 | 2022-06-23 | サンスター株式会社 | Oral composition |
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