JP2006111560A - Ceramide synthesis promoter - Google Patents
Ceramide synthesis promoter Download PDFInfo
- Publication number
- JP2006111560A JP2006111560A JP2004299675A JP2004299675A JP2006111560A JP 2006111560 A JP2006111560 A JP 2006111560A JP 2004299675 A JP2004299675 A JP 2004299675A JP 2004299675 A JP2004299675 A JP 2004299675A JP 2006111560 A JP2006111560 A JP 2006111560A
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- extract
- production example
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- skin
- ethanol
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- 229940106189 ceramide Drugs 0.000 title claims abstract description 32
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- ZVEQCJWYRWKARO-UHFFFAOYSA-N ceramide Natural products CCCCCCCCCCCCCCC(O)C(=O)NC(CO)C(O)C=CCCC=C(C)CCCCCCCCC ZVEQCJWYRWKARO-UHFFFAOYSA-N 0.000 title claims abstract description 31
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Abstract
Description
本発明は、コメ、クズ、アンズ、スイカズラ、ユキノシタ、テンチャ、ラフマ、サンザシ、イザヨイバラ、エゾウコギ、ナツメ、シソ、オウレン、サイシン、コガネバナ、キハダ、クワ、ボタン、シャクヤク、チンピ、ムクロジ、チョウジ、ユリ、ダイズおよびシロキクラゲの抽出物から選ばれる1種又は2種以上を含有することを特徴とするセラミド合成促進剤に関し、特に肌荒れ、乾燥肌の防止に有効性を発揮する組成物に関するものである。 The present invention includes rice, kudzu, apricot, honeysuckle, snow flake, tencha, rafma, hawthorn, izayoibara, ezokogi, jujube, perilla, auren, saishin, koganebana, kihada, mulberry, button, peonies, chimpi, mukuroji, clove, lily, The present invention relates to a ceramide synthesis promoter characterized by containing one or more selected from soybean and white jellyfish extracts, and particularly to a composition that exhibits effectiveness in preventing rough skin and dry skin.
セラミドは、皮膚の基底層から角質層に細胞が移行する際に、上層の有棘層および顆粒層で産生、分泌される層板顆粒の主成分であり、皮膚のバリア機能や水分保持能に重要な役割を果たす角質細胞間脂質を形成する。肌荒れの一因として乾燥や刺激物との接触や紫外線等による皮膚の炎症がある。乾燥や刺激物から肌を守るバリア機能の回復において、セラミドの産生を促進することが有効であるとされている。ヒト皮膚には、７系統のセラミドが存在することが確認されており、全種類のセラミドが角質層に存在する比率で補うことが理想的である。 Ceramide is the main component of lamellar granules produced and secreted in the upper spiny layer and granule layer when cells move from the basal layer of the skin to the stratum corneum. Forms keratinocyte lipids that play an important role. Causes of rough skin include dryness, contact with irritants, and skin irritation due to ultraviolet rays. It is said that promoting the production of ceramide is effective in restoring the barrier function that protects the skin from dryness and irritants. It has been confirmed that seven types of ceramide are present in human skin, and it is ideal that all kinds of ceramides are supplemented at a ratio of existing in the stratum corneum.
従来、この様な肌荒れ、乾燥肌の予防改善に有効な化粧料として、セラミドが種々の皮膚外用剤に配合されているが、ヒトの皮膚に存在する全種類のセラミドを適正な比率で補充することは技術的に困難であった。したがって、生体内におけるセラミド合成を促進する事が重要であると考えられる。セラミド合成促進剤としては、特許文献１や特許文献２が報告されている。なお、コメ、クズ、アンズ、スイカズラ、ユキノシタ、テンチャ、ラフマ、サンザシ、イザヨイバラ、エゾウコギ、ナツメ、シソ、オウレン、サイシン、コガネバナ、キハダ、クワ、ボタン、シャクヤク、チンピ、ムクロジ、チョウジ、ユリ、ダイズおよびシロキクラゲの抽出物のセラミド合成促進効果については報告されていない。
以上のことから、肌荒れ、乾燥肌の改善効果に優れたセラミド合成促進剤が望まれている。 From the above, a ceramide synthesis accelerator excellent in the effect of improving rough skin and dry skin is desired.
この様な事情により、本発明者らは鋭意研究検討した結果、コメ、クズ、アンズ、スイカズラ、ユキノシタ、テンチャ、ラフマ、サンザシ、イザヨイバラ、エゾウコギ、ナツメ、シソ、オウレン、サイシン、コガネバナ、キハダ、クワ、ボタン、シャクヤク、チンピ、ムクロジ、チョウジ、ユリ、ダイズおよびシロキクラゲの抽出物によりセラミド合成が促進されることを見出し、さらにそれらの抽出物から選ばれる1種又は2種以上を含有する組成物に肌荒れ、乾燥肌の予防改善効果を見出し、本発明を完成するに至った。 Under these circumstances, as a result of intensive research and investigation, the present inventors have found that rice, kudzu, apricot, honeysuckle, saxifrage, tencha, rafma, hawthorn, izayoibara, ezokogi, jujube, perilla, ouren, saishin, koganebana, kihada, quail , Button, peonies, chimpi, mugwort, clove, lily, soybean, and white jellyfish extracts are found to promote ceramide synthesis, and further to a composition containing one or more selected from these extracts The present inventors have found the effect of preventing and improving rough skin and dry skin, and have completed the present invention.
本発明に用いるコメは、イネ科に属するＯｒｙｚａ ｓａｔｉｖａ Ｌの果実であり、玄米や米ヌカなどを利用することができる。 The rice used in the present invention is the fruit of Oryza sativa L belonging to the family Gramineae, and brown rice or rice bran can be used.
本発明に用いるクズは、マメ科に属し、学名：Ｐｕｅｒａｒｉａ ｌｏｂａｔａ ｏｈｗｉであり、東アジアやインド、マレー半島方面の熱帯から一部の温帯まで野生し、日本では北海道から九州まで普通に見られる大型の多年草である。クズの周皮を除いた根の部分（生薬名：葛根）などを利用することができる。また葛根として流通する近縁植物を用いてもよい。 Kudu used in the present invention belongs to the leguminous family and has the scientific name: Pueraria lobata ohwi. It is wild from eastern Asia, India, and the tropics of the Malay Peninsula to some temperate zones. Is a perennial. You can use the root part (herbal medicine name: kakkon), etc., excluding the pericarp. Moreover, you may use the related plant which distribute | circulates as a kudzu root.
本発明に用いるアンズは、バラ科に属し、例えば、ホンアンズ（Ｐｒｕｎｕｓ ａｒｍｅｎｉａｃａ Ｌ）、アンズ（Ｐｒｕｎｕｓ ａｒｍｅｎｉａｃａ Ｌ．ｖａｒ．ａｎｓｕ Ｍａｘｉｍｏｗｉｃｚ）またはその他近縁植物の種子を乾燥したもの（生薬名：杏仁）などを利用することができる。 The apricot used in the present invention belongs to the family Rosaceae, such as dried apricot (Prunus armenica L), apricot (Prunus armenica L. var. Ans Maximowicz) or other related plant seeds (herbal medicine name: apricot kernel) Can be used.
本発明に用いるスイカズラはスイカズラ科に属し、スイカズラ（学名：Ｌｏｎｉｃｅｒａ Ｊａｐｏｎｉｃａ Ｔｈｉｎｂｅｒｇ）又はその他同属植物であり、日本や中国などに自生するツル性の植物である。枝ごと摘み刻むか、または葉だけを摘み取り乾燥したもの（生薬名：忍冬）や花部を乾燥したもの（生薬名：金銀花）などを利用することができる。 The honeysuckle used in the present invention belongs to the family Lonicera, and is a honeysuckle (scientific name: Lonicera Japanpica Thinberg) or other related genus plant, and is a vine plant that grows naturally in Japan, China and the like. It is possible to use things that are picked and chopped with branches, or leaves that are picked and dried (herbal medicine name: Shinobu) or dried flower parts (herbal medicine name: gold and silver flowers).
本発明に用いるユキノシタはユキノシタ科に属し、学名：Ｓａｘｉｆｒａｇａ ｓｔｏｌｏｎｉｆｅｒａ（Ｌ．） Ｍｅｅｒｂであり、日本や中国などに分布する多年性草本である。全草を利用することができる。 The saxifrage used in the present invention belongs to the family Saxifragaceae and has the scientific name: Saxifraga stolonifera (L.) Meerb, which is a perennial herb distributed in Japan, China, and the like. Whole grass can be used.
本発明に用いるテンチャはバラ科に属し、学名：Ｒｕｂｕｓ ｓｕａｖｉｓｓｉｍｕｓ Ｓｈｕｇａｎ Ｌｅｅであり、中国南西部の山岳地帯にのみ産し、開胃茶とも呼ばれ、食欲増進、去痰、咳止めとして用いられている。葉を乾燥したもの（生薬名：甜茶）などを利用することができる。 The tencha used in the present invention belongs to the family Rosaceae and has the scientific name: Rubus suavissimus Shugan Lee, which is produced only in the mountainous area of southwestern China, and is also called open stomach tea, and is used as an appetite booster, expectorant and cough. The dried leaves (herbal medicine name: tea) can be used.
本発明で用いられるラフマ（羅布麻、学名：Ａｐｏｃｙｎｕｍ ｖｅｎｅｔｕｍ Ｌ．）は、キョウチクトウ科の低木である。主に中国の北西部に分布し、その葉、茎など植物の一部や全草を乾燥したものなどを利用することができる。 Raffma (Rafu hemp, scientific name: Apocynum venetum L.) used in the present invention is a shrub of the Oleander family. It is mainly distributed in the northwestern part of China, and it is possible to use parts of plants such as leaves and stems or dried whole plants.
本発明に用いるサンザシはバラ科に属し、サンザシ（学名：Ｃｒａｔａｅｇｕｓ ｃｕｎｅａｔａ Ｓｉｅｂ．ｅｔ Ｚｕｃｃ）又はその近縁植物であり、中国の各省や日本に分布する落葉低木である。果実の部分を乾燥したもの（生薬名：山査子）などを利用することができる。 The hawthorn used in the present invention belongs to the family Rosaceae and is a hawthorn (Scientific name: Crataegus cuneata Sieb. Et Zucc) or a related plant thereof, and is a deciduous shrub distributed in various provinces of China and Japan. What dried the fruit part (namely, herbal medicine: Yamako) can be used.
本発明に用いるイザヨイバラはバラ科に属し、学名：Ｒｏｓａ ｒｏｘｂｕｒｇｈｉｉ Ｔｒａｆｆ．ｆ． ｎｏｒｍａｌｉｓ Ｒｅｈｄ．ｅｔ Ｗｉｌｓである。果実を乾燥したもの（生薬名：刺梨）などを利用することができる。 The Izayoi rose used in the present invention belongs to the family Rosaceae and has a scientific name: Rosa roxburghii Traffic. f. normalis Rehd. et Wils. The dried fruit (herbal medicine name: pear) can be used.
本発明に用いるエゾウコギはウコギ科に属し、学名：Ａｃａｎｔｈｏｐａｎａｘ ｓｅｎｔｉｃｏｓｕｓ Ｈａｒｍｓであり、北海道、樺太、朝鮮半島、中国大陸北部、アムール地方に分布する。根皮を乾燥したもの（生薬名：五加皮）などを利用することができる。 Ezoukogi used in the present invention belongs to the family Uridaceae, and has the scientific name: Acanthopanax senticosus Harms, and is distributed in Hokkaido, Saita, the Korean Peninsula, northern China, and Amur. What dried the root bark (namely, crude drug name: five skins) etc. can be used.
本発明に用いるナツメはクロウメモドキ科に属し、ナツメ（学名：Ｚｉｚｙｐｈｕｓ ｊｕｊｕｂａ ｖａｒ．ｉｎｅｒｍｉｓ Ｒｅｈｄ）又はその近縁植物であり、北アメリカからヨーロッパ西部に原産地がある落葉性高木である。果実を乾燥したもの（生薬名：大棗）などを利用することができる。 The jujube used in the present invention belongs to the family Oleaceae, and is a jujube (scientific name: Zizyhus jujuba var. Inermis Rehd) or a related plant thereof, and is a deciduous tree that originates from North America to western Europe. The dried fruit (herbal medicine name: Daegu) can be used.
本発明に用いるシソはシソ科に属し、シソ（学名：Ｐｅｒｉｌｌａ Ｆｒｕｔｅｓｃｅｎｓ ｖａｒ Ａｃｕｔａ）又はその近縁植物であり、中国が原産地である。葉を乾燥させたもの（生薬名：蘇葉）や種子を乾燥させたもの（生薬名：紫蘇子）などを利用することができる。 The perilla used in the present invention belongs to the family Lamiaceae, and is perilla (Perilla Fruitscens var Acta) or a related plant thereof, and its origin is China. Those obtained by drying leaves (name of crude drugs: Soyo), those obtained by drying seeds (name of crude drugs: Shiso) can be used.
本発明に用いるオウレンはキンポウゲ科に属し、オウレン（学名：Ｃｏｐｔｉｓ ｊａｐｏｎｉｃａ）又はその他同属植物であり、北海道西南部から本州、四国に分布する林床植物であり、その根茎を乾燥したもの（生薬名：黄連）などを利用することができる。 The auren used in the present invention belongs to the family Ranunculaceae, and is an oren (scientific name: Coptis japonica) or other related plant, and is a forest floor plant distributed from the southwestern Hokkaido to Honshu and Shikoku, with dried rhizomes (name of crude drugs : Henren) etc.
本発明で用いられるサイシンは、ウマノスズクサ科のケイリンサイシン（学名：Ａｓｉａｓａｒｕｍ ｈｅｔｅｒｏｔｒｏｐｏｉｄｅｓ Ｆ．）またはウスバサイシン（学名：Ａｓｉａｓａｒｕｍ ｓｉｅｂｏｌｄｉ Ｆ．）であり、根茎および根、または根つき全草を乾燥したもの（生薬名：細辛）などを利用することができる。 The saicin used in the present invention is Keirinsaicin (scientific name: Asiasarum heterotropides F.) or Usbasaicin (scientific name: Asiasarum sieboldi F.), which is obtained by drying rhizomes and roots, or rooted whole plants (herbal medicines). Name: Spicy) can be used.
本発明に用いるコガネバナはシソ科に属し、学名：Ｓｃｕｔｅｌｌａｒｉａ ｂａｉｃａｌｅｎｓｉｓ Ｇｅｏｒｇｉであり、中国北部からシベリア、日本では群馬県や奈良県で栽培される、多年生草本である。根を乾燥したもの（生薬名：黄ごん）などを利用することができる。また、黄ごんとして流通する同属植物を用いてもよい。 Scarabae used in the present invention belongs to the family Lamiaceae and has the scientific name: Scutellaria baicalensis Georgi. It is a perennial herb grown in Siberia from northern China and in Gunma and Nara prefectures in Japan. Dry roots (herbal medicine name: yellow rice) can be used. Moreover, you may use the same genus plant distribute | circulated as yellow rice.
本発明に用いるキハダはミカン科に属し、キハダ（学名：Ｐｈｅｌｌｏｄｅｎｄｒｏｎ ａｍｕｒｅｎｓｅ Ｒｕｐｒｅｃｈｔ）又はその他同属植物であり、アムール川、中国北部、日本列島に広く分布する落葉高木である。周皮を除いた樹皮を乾燥したもの（生薬名：黄柏）などを利用することができる。 The yellowfin used in the present invention belongs to the citrus family and is yellowfin (Scientific name: Phellodendron amurense Ruprecht) or other related plants, and is a deciduous tree widely distributed in the Amur River, northern China and the Japanese archipelago. The dried bark excluding the pericard (herbal medicine name: jaundice) can be used.
本発明に用いるクワはクワ科に属し、マグワ（学名：Ｍｏｒｕｓ ａｌｂａ Ｌ．）又はその他同属植物であり、アムール川、中国原産の落葉高木である。根皮を乾燥させたもの（生薬名：桑白皮）などを利用することができる。 The mulberry used in the present invention belongs to the mulberry family and is a mulberry (scientific name: Morus alba L.) or other related plant, and is a deciduous tree native to the Amur River, China. What dried the root bark (namely, crude drug name: mulberry skin) etc. can be used.
本発明に用いるボタンはボタン科に属し、学名：Ｐａｅｏｎｉａ ｓｕｆｆｒｕｔｉｃｏｓａ Ａｎｄｒｅｗｓ Ｐａｅｏｎｉａであり、中国西北部原産の落葉性低木である。根皮を乾燥したもの（生薬名：牡丹皮）などを利用することができる。 The button used in the present invention belongs to the button family, and has the scientific name: Paeonia suffruticosa Andrews Paeonia, which is a deciduous shrub native to northwestern China. What dried the root bark (namely, herbal medicine: peony skin) etc. can be used.
本発明に用いるシャクヤクはボタン科に属し、シャクヤク（学名：Ｐａｅｏｎｉａ ｌａｃｔｉｆｌｏｒａ Ｐａｌｌａｓ）又はその近縁植物であり、中国東北部、東シベリア、朝鮮半島に分布する多年生草本である。根を乾燥させたもの（生薬名：芍薬）などを利用することができる。 The peony used in the present invention belongs to the button family, and is a peony (scientific name: Paeonia lactiflora Pallas) or a related plant thereof, and is a perennial herb distributed in Northeast China, East Siberia, and the Korean Peninsula. The dried roots (herbal medicine name: glaze) can be used.
本発明に用いるチンピはミカン科に属し、ウンシュウミカン（学名：Ｃｉｔｒｕｓ ｕｎｓｈｉｕ Ｍａｒｃｏｖ）又はその近縁植物であり、果実の皮を乾燥したもの（生薬名：陳皮）などを利用することができる。 The chimney used in the present invention belongs to the citrus family, and can be used in the citrus unshiu marcov (scientific name: Citrus unshiu Markov) or a related plant thereof, in which fruit skin is dried (name of crude drug: cheng).
本発明に用いるムクロジはムクロジ科に属し、学名：Ｓａｐｉｎｄｕｓ ｍｕｋｏｒｏｓｓｉ Ｇａｅｒｔｎであり、日本、台湾、中国、インド、ネパールに分布する落葉性高木である。果皮を乾燥させたもの（生薬名：延命皮）などを利用することができる。 Mukuroji used in the present invention belongs to the family Mukurodiaceae and has the scientific name: Sapindus mukorossi Gaertn, and is a deciduous tree distributed in Japan, Taiwan, China, India and Nepal. It is possible to use a dried fruit skin (name of crude drug: life-extending skin).
本発明に用いるチョウジはフトモモ科に属し、学名：Ｓｙｚｙｇｉｕｍ ａｒｏｍａｔｉｃｕｍ Ｍｅｒｒｉｌｌ ｅｔ Ｐｅｒｒｙであり、日本、台湾、中国、インド、ネパールに分布する落葉性高木であり、花蕾を乾燥したもの（生薬名：丁字）などを利用することができる。 The clove used in the present invention belongs to the Myrtaceae family and has the scientific name: Syzygium aromaticum Merrill et Perry, which is a deciduous tree distributed in Japan, Taiwan, China, India, Nepal, and dried florets (herbal medicine name: nickname) Etc. can be used.
本発明に用いるユリは、ユリ科ユリ属に属し、例えばマドンナリリー（学名：Ｌｉｌｉｕｍ ｃａｎｄｉｄｕｍ）またはハカタユリ（学名：Ｌｉｌｉｕｍ ｂｒｏｗｎｉｉ Ｆ．Ｅ．Ｂ．）、ヒメユリ（学名：Ｌｉｌｉｕｍ ｃｏｎｃｏｌｏｒ Ｓ．）、オニユリ（Ｌｉｌｉｕｍ ｌａｎｃｉｆｏｌｉｕｍ Ｔ．）、ヤマユリ（学名：Ｌｉｌｉｕｍ ａｕｒａｔｕｍ Ｌ．）の球根を乾燥したもの（生薬名：百合）などを利用することができる。 The lily used in the present invention belongs to the genus Lily of the family Lilyaceae. For example, Madonna Lily (scientific name: Lilium candidum) or Hakatayuri (scientific name: Lilium brownii FE), Himeyuri (scientific name: Lilium controller S.) Lilium lancifolium T.), dried lily bulb (scientific name: Lilium auratum L.) bulbs (herbal medicine name: lily) and the like can be used.
本発明に用いるダイズはマメ科に属し、学名：Ｇｌｙｃｉｎｅ ｍａｘ Ｍｅｒｒｉｌｌであり、中国原産の一年草である。胃腸を整え、鬱血散らす効果をもつとして、古くから用いられている。種子または種子から抽出したDaidzinなどのイソフラボン類などを利用することができる。 The soybean used in the present invention belongs to the leguminous family and has the scientific name: Glycine max Merrill, and is an annual plant native to China. It has been used since ancient times for its gastrointestinal preparation and the effect of spreading congestion. Isoflavones such as Daidzin extracted from seeds or seeds can be used.
本発明で用いるシロキクラゲ（学名：Ｔｒｅｍｅｌｌａ ｆｕｃｉｆｏｒｍｉｓ Ｂ．）は、シロキクラゲ科に属するキノコで、子実体、菌体などを利用することができる。 The white jellyfish used in the present invention (scientific name: Tremella fuciformis B.) is a mushroom belonging to the family Asteraceae, and can use fruit bodies, fungus bodies, and the like.
本発明のコメ、クズ、アンズ、スイカズラ、ユキノシタ、テンチャ、ラフマ、サンザシ、イザヨイバラ、エゾウコギ、ナツメ、シソ、オウレン、サイシン、コガネバナ、キハダ、クワ、ボタン、シャクヤク、チンピ、ムクロジ、チョウジ、ユリ、ダイズおよびシロキクラゲの抽出物は特に限定されず、例えば、加熱抽出したものであっても良いし、常温又は低温で抽出したものであっても良い。抽出する溶媒としては、例えば、水、低級アルコール類（メタノール、エタノール、１−プロパノール、２−プロパノール、１−ブタノール、２−ブタノール等）、液状多価アルコール（１，３−ブチレングリコール、プロピレングリコール、グリセリン等）、ケトン類（アセトン、メチルエチルケトン等）、アセトニトリル、エステル類（酢酸エチル、酢酸ブチル等）、炭化水素類（ヘキサン、ヘプタン、流動パラフィン等）、エーテル類（エチルエーテル、テトラヒドロフラン、プロピルエーテル等）が挙げられる。好ましくは、水、低級アルコールおよび液状多価アルコール等の極性溶媒が良く、特に好ましくは、水、エタノール、１，３−ブチレングリコールおよびプロピレングリコールが良い。これらの溶媒は１種でも２種以上を混合して用いても良い。 Rice, crumbs, apricots, honeysuckle, marsh, tencha, rafma, hawthorn, izayoibara, ezokogi, jujube, perilla, lauren, saishin, koganebana, kihada, mulberry, button, peonies, chimpi, mukuroji, choji, lily, soybean The extract of white jellyfish is not particularly limited, and for example, it may be extracted by heating, or may be extracted at normal temperature or low temperature. Examples of the solvent to be extracted include water, lower alcohols (methanol, ethanol, 1-propanol, 2-propanol, 1-butanol, 2-butanol, etc.), liquid polyhydric alcohols (1,3-butylene glycol, propylene glycol). , Glycerin, etc.), ketones (acetone, methyl ethyl ketone, etc.), acetonitrile, esters (ethyl acetate, butyl acetate, etc.), hydrocarbons (hexane, heptane, liquid paraffin, etc.), ethers (ethyl ether, tetrahydrofuran, propyl ether) Etc.). Preferred are polar solvents such as water, lower alcohols and liquid polyhydric alcohols, and particularly preferred are water, ethanol, 1,3-butylene glycol and propylene glycol. These solvents may be used alone or in combination of two or more.
上記抽出物は、抽出した溶液のまま用いても良く、必要に応じて、濃縮、希釈、濾過、活性炭等による脱色、脱臭等の処理をして用いても良い。更には、抽出した溶液を濃縮乾固、噴霧乾燥、凍結乾燥等の処理を行い、乾燥物として用いても良いし、カラム精製等を行って有効成分を濃縮したり単離してから用いても良い。 The extract may be used as it is, or may be used after concentration, dilution, filtration, decolorization with activated carbon, deodorization, or the like, if necessary. Further, the extracted solution may be used as a dried product after being concentrated and dried, spray dried, freeze dried, etc., or may be used after concentrating or isolating the active ingredient by performing column purification or the like. good.
本発明のコメ、クズ、アンズ、スイカズラ、ユキノシタ、テンチャ、ラフマ、サンザシ、イザヨイバラ、エゾウコギ、ナツメ、シソ、オウレン、サイシン、コガネバナ、キハダ、クワ、ボタン、シャクヤク、チンピ、ムクロジ、チョウジ、ユリ、ダイズおよびシロキクラゲの抽出物から選ばれる１種又は２種以上を含有することを特徴とするセラミド合成促進剤を肌荒れ改善の目的で用いるには、通常全身的又は局所的に内用や外用により投与される。投与量は、年齢、体重、症状、治療効果、投与方法、処理時間などにより異なるが、通常成人１人当たり１回に１ｍｇ〜１ｇ、好ましくは２０ｍｇ〜２００ｍｇの範囲で１日１回から数回投与される。投与量は種々の条件で変動するので、上記投与範囲より少ない量で十分な場合もあるし、また、範囲を超えて投与する必要のある場合もある。 Rice, crumbs, apricots, honeysuckle, marsh, tencha, rafma, hawthorn, izayoibara, ezokogi, jujube, perilla, lauren, saishin, koganebana, kihada, mulberry, button, peonies, chimpi, mukuroji, choji, lily, soybean In order to improve rough skin, a ceramide synthesis promoter characterized by containing one or two or more selected from the extract of white jellyfish is usually administered systemically or locally for internal or external use. The The dose varies depending on age, body weight, symptoms, therapeutic effect, administration method, treatment time, etc., but is usually 1 mg to 1 g per adult, preferably 20 mg to 200 mg once to several times a day. Is done. Since the dosage varies depending on various conditions, an amount smaller than the above-mentioned administration range may be sufficient, or it may be necessary to administer beyond the range.
本発明の経口投与のためのセラミド合成促進剤としては、食品、医薬部外品および医薬品のいずれにも用いることができ、錠剤、丸剤、散剤、顆粒剤、カプセル剤、乳濁剤、溶液剤、懸濁剤、シロップ剤、エリキシル剤などが挙げられる。上記抽出物をそのまま使用しても良く、抽出物の効果を損なわない範囲内で、賦形剤、増量剤、結合剤、湿潤剤、崩壊剤、界面活性剤、滑沢剤、分散剤、緩衝剤、香料、保存料、溶解補助剤、溶剤等を用いることができる。具体的には、乳糖、ショ糖、ソルビット、マンニット、澱粉、沈降性炭酸カルシウム、重質酸化マグネシウム、タルク、ステアリン酸カルシウム、ステアリン酸マグネシウム、セルロース又はその誘導体、アミロペクチン、ポリビニルアルコール、ゼラチン、界面活性剤、水、生理食塩水、エタノール、グリセリン、プロピレングリコール、カカオ脂、ラウリン脂、ワセリン、パラフィン、高級アルコール等である。 As the ceramide synthesis promoter for oral administration of the present invention, it can be used for any of foods, quasi drugs and pharmaceuticals, tablets, pills, powders, granules, capsules, emulsions, solutions Agents, suspensions, syrups, elixirs and the like. The above extract may be used as it is, and the excipient, extender, binder, wetting agent, disintegrant, surfactant, lubricant, dispersant, buffer, as long as the effect of the extract is not impaired. Agents, fragrances, preservatives, solubilizers, solvents and the like can be used. Specifically, lactose, sucrose, sorbit, mannitol, starch, precipitated calcium carbonate, heavy magnesium oxide, talc, calcium stearate, magnesium stearate, cellulose or derivatives thereof, amylopectin, polyvinyl alcohol, gelatin, surface activity Agents, water, physiological saline, ethanol, glycerin, propylene glycol, cacao butter, lauric fat, petrolatum, paraffin, higher alcohol and the like.
本発明の外用のためのセラミド合成促進剤は、化粧品、医薬部外品および医薬品のいずれにも用いることができ、その剤型としては、例えば、化粧水、クリーム、乳液、ゲル剤、エアゾール剤、エッセンス、パック、洗浄剤、浴用剤、ファンデーション、打粉、口紅、軟膏、パップ剤等の皮膚に適用されるものが挙げられる。上記抽出物をそのまま使用しても良く、抽出物の効果を損なわない範囲内で、外用剤に用いられる成分である油脂類、ロウ類、炭化水素類、脂肪酸類、アルコール類、エステル類、界面活性剤、金属石鹸、ｐＨ調整剤、防腐剤、香料、保湿剤、粉体、紫外線吸収剤、増粘剤、色素、酸化防止剤、美白剤、キレート剤等の成分を配合することもできる。 The ceramide synthesis promoter for external use of the present invention can be used in any of cosmetics, quasi drugs and pharmaceuticals. Examples of the dosage form thereof include lotions, creams, emulsions, gels, and aerosols. , Essences, packs, cleaning agents, bath preparations, foundations, dusting powders, lipsticks, ointments, poultices, and the like. The above-mentioned extract may be used as it is, and the components used for the external preparation are within the range not impairing the effect of the extract, oils, waxes, hydrocarbons, fatty acids, alcohols, esters, interfaces Components such as activators, metal soaps, pH adjusters, preservatives, fragrances, moisturizers, powders, ultraviolet absorbers, thickeners, dyes, antioxidants, whitening agents, chelating agents, and the like can also be blended.
本発明に用いる上記抽出物の配合量は、本発明のセラミド合成促進剤に対し、固形物に換算して０．０００１重量％以上、好ましくは０．００１〜５０重量％の配合が良い。０．０００１重量％未満では十分な効果は望みにくい。５０重量％を越えて配合した場合、効果の増強はみられにくく不経済である。また、添加の方法については、予め加えておいても、製造途中で添加しても良く、作業性を考えて適宜選択すれば良い。 The amount of the extract used in the present invention is 0.0001% by weight or more, preferably 0.001 to 50% by weight, in terms of solid matter, based on the ceramide synthesis accelerator of the present invention. If it is less than 0.0001% by weight, a sufficient effect is hardly expected. When it exceeds 50% by weight, the effect is hardly increased and it is uneconomical. In addition, the addition method may be added in advance or during the production, and may be appropriately selected in consideration of workability.
本発明のコメ、クズ、アンズ、スイカズラ、ユキノシタ、テンチャ、ラフマ、サンザシ、イザヨイバラ、エゾウコギ、ナツメ、シソ、オウレン、サイシン、コガネバナ、キハダ、クワ、ボタン、シャクヤク、チンピ、ムクロジ、チョウジ、ユリ、ダイズおよびシロキクラゲの抽出物はセラミド合成促進効果に優れていた。また、これらの抽出物を1種又は2種以上含有する皮膚外用剤は、安全で肌荒れ、乾燥肌の改善効果に優れていた。 Rice, crumbs, apricots, honeysuckle, marsh, tencha, rafma, hawthorn, izayoibara, ezokogi, jujube, perilla, lauren, saishin, koganebana, kihada, mulberry, button, peonies, chimpi, mukuroji, choji, lily, soybean And the extract of white jellyfish was excellent in ceramide synthesis promoting effect. In addition, a skin external preparation containing one or more of these extracts was safe, rough skin, and excellent in improving dry skin.
次に本発明を詳細に説明するため、実施例として本発明に用いる抽出物の製造例、本発明の処方例および実験例を挙げるが、本発明はこれに限定されるものではない。実施例に示す配合量の部とは重量部を示し、％は重量％を示す。 Next, in order to describe the present invention in detail, examples of producing the extract used in the present invention, formulation examples of the present invention, and experimental examples will be given as examples, but the present invention is not limited thereto. The part of the amount shown in the examples indicates part by weight, and% indicates% by weight.
製造例１ コメの熱水抽出物
米ヌカ１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してコメの熱水抽出物を３．５ｇ得た。
Production Example 1 Hot water extract of rice 2 L of purified water was added to 100 g of rice bran, extracted at 95-100 ° C. for 2 hours, filtered, and the filtrate was concentrated and freeze-dried to obtain a hot water extract of rice. 3.5 g was obtained.
製造例２ コメのエタノール抽出物
米ヌカ１００ｇにエタノール２Ｌを加え、常温で７日間抽出した後、濾過し、その濾液を濃縮乾固して、コメのエタノール抽出物を３．７ｇ得た。
Production Example 2 Rice Ethanol Extract 2L of ethanol was added to 100 g of rice bran and extracted at room temperature for 7 days, followed by filtration. The filtrate was concentrated to dryness to obtain 3.7 g of rice ethanol extract.
製造例３ クズの熱水抽出物
クズの葉の乾燥物１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してクズの熱水抽出物を２．７ｇ得た。
Production Example 3 Hot Water Extract of Scratch 2 L of purified water was added to 100 g of a dried product of Scrap leaves and extracted at 95-100 ° C. for 2 hours, followed by filtration. 2.7 g of water extract was obtained.
製造例４ クズのエタノール抽出物
葛根１００ｇにエタノール２Ｌを加え、常温で７日間抽出した後、濾過し、その濾液を濃縮乾固して、クズのエタノール抽出物を４．２ｇ得た。
Production Example 4 Ethanol extract of kudzu 2 L of ethanol was added to 100 g of kudzu root and extracted at room temperature for 7 days, followed by filtration. The filtrate was concentrated to dryness to obtain 4.2 g of kudzu ethanol extract.
製造例５ アンズの５０％１，３−ブチレングリコール水溶液抽出物
アンズの葉の乾燥物２０ｇに精製水２００ｍＬおよび１，３−ブチレングリコール２００ｍＬを加え、常温で7日間抽出した後、濾過し、アンズの５０％１，３−ブチレングリコール抽出物を３７０ｇ得た。
Production Example 5 Extract of apricot 50% 1,3-butylene glycol aqueous solution To 20 g of dried apricot leaves, 200 mL of purified water and 200 mL of 1,3-butylene glycol were added, extracted at room temperature for 7 days, filtered, and apricot. 370 g of 50% 1,3-butylene glycol extract was obtained.
製造例６ アンズのエタノール抽出物
杏仁１００ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固してアンズのエタノール抽出物を５．５ｇ得た。
Production Example 6 Apricot ethanol extract 1 L of ethanol was added to 100 g of apricot kernel, extracted at room temperature for 7 days, filtered, and the filtrate was concentrated to dryness to obtain 5.5 g of apricot ethanol extract.
製造例７ スイカズラの熱水抽出物
忍冬１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してスイカズラの熱水抽出物を２．９ｇ得た。
Production Example 7 Hot water extract of honeysuckle 2 L of purified water was added to 100 g of Shinobi winter, extracted at 95-100 ° C. for 2 hours, filtered, the filtrate was concentrated, freeze-dried, and 2 hot water extract of honeysuckle was obtained. .9 g was obtained.
製造例８ スイカズラのエタノール抽出物
金銀花１００ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固してスイカズラのエタノール抽出物を５．８ｇ得た。
Production Example 8 Honeysuckle ethanol extract 1 L of ethanol was added to 100 g of gold and silver flowers, extracted at room temperature for 7 days, filtered, and the filtrate was concentrated to dryness to obtain 5.8 g of honeysuckle ethanol extract.
製造例９ ユキノシタの熱水抽出物
ユキノシタの全草の乾燥物２５ｇに精製水８００ｍＬを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してユキノシタの熱水抽出物を３．２ｇ得た。
Production Example 9 Hot Water Extract of Yukinoshita 800 ml of purified water was added to 25 g of a dried whole plant of Yukinoshita, extracted at 95-100 ° C. for 2 hours, filtered, and the filtrate was concentrated and freeze-dried. 3.2 g of hot water extract was obtained.
製造例１０ テンチャのエタノール抽出物
テンチャの全草の乾燥物１００ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固してテンチャのエタノール抽出物を４．７ｇ得た。
Production Example 10 Tencha Ethanol Extract 1 L of ethanol was added to 100 g of dried tencha plant, extracted at room temperature for 7 days, filtered, and the filtrate was concentrated to dryness to obtain 4.7 g of tencha ethanol extract. Obtained.
製造例１１ ラフマのエタノール抽出物
ラフマの葉および茎の乾燥物１００ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固してラフマのエタノール抽出物を４．５ｇ得た。
Production Example 11 Raffa Ethanol Extract 1 L of ethanol was added to 100 g of dried Raffa leaves and stems, extracted at room temperature for 7 days, filtered, and the filtrate was concentrated to dryness to obtain Raffa ethanol extract. 5 g was obtained.
製造例１２ サンザシの５０％１，３−ブチレングリコール水溶液抽出物
山査子２０ｇに精製水２００ｍＬおよび１，３−ブチレングリコール２００ｍＬを加え、常温で7日間抽出した後、濾過し、サンザシの５０％１，３−ブチレングリコール抽出物を３３０ｇ得た。
Production Example 12 Hawthorn 50% 1,3-butylene glycol aqueous solution extract 20 ml of Yamashiko was added 200 mL of purified water and 200 mL of 1,3-butylene glycol, extracted for 7 days at room temperature, filtered, 330 g of 3-butylene glycol extract was obtained.
製造例１３ イザヨイバラの熱水抽出物
イザヨイバラの葉および茎の乾燥物２５ｇに精製水８００ｍＬを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してイザヨイバラの熱水抽出物を３．０ｇ得た。
Production Example 13 Hot Water Extract of Isaiyobara Add 800 mL of purified water to 25 g of dried leaves and stems of Isaiyobara, extract at 95-100 ° C. for 2 hours, filter, concentrate the filtrate, freeze-dry, 3.0 g of a hot water extract was obtained.
製造例１４ イザヨイバラのエタノール抽出物
刺梨１００ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固し、イザヨイバラのエタノール抽出物を６．７ｇ得た。
Production Example 14 Isaiyobara Ethanol Extract 1 L of ethanol was added to 100 g of pear and extracted at room temperature for 7 days, followed by filtration. The filtrate was concentrated to dryness to obtain 6.7 g of Isaiyobara ethanol extract.
製造例１５ エゾウコギの熱水抽出物
エゾウコギの根の乾燥物２０ｇに精製水８００ｍＬを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してエゾウコギの熱水抽出物を３．７ｇ得た。
Production Example 15 Hot water extract of Ekokogi 800 mL of purified water was added to 20 g of dried dried Ezogi root, extracted at 95-100 ° C. for 2 hours, filtered, and the filtrate was concentrated, freeze-dried and heated 3.7g of water extract was obtained.
製造例１６ ナツメの熱水抽出物
ナツメの葉の乾燥物２０ｇに精製水８００ｍＬを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してナツメの熱水抽出物を３．３ｇ得た。
Production Example 16 Hot water extract of jujube 800 ml of purified water was added to 20 g of dried jujube leaves, extracted at 95-100 ° C. for 2 hours, filtered, and the filtrate was concentrated, freeze-dried, 3.3 g of water extract was obtained.
製造例１７ ナツメのエタノール抽出物
大棗１００ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固し、ナツメのエタノール抽出物を５．９ｇ得た。
Production Example 17 Ethanol Extract of Jujube 1 L of ethanol was added to 100 g of jujube and extracted at room temperature for 7 days, followed by filtration. The filtrate was concentrated to dryness to obtain 5.9 g of jujube ethanol extract.
製造例１８ シソのエタノール抽出物
シソの葉の乾燥物５０ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固し、シソのエタノール抽出物を９．８ｇ得た。
Production Example 18 Perilla ethanol extract 1L of ethanol was added to 50 g of dried perilla leaves, extracted at room temperature for 7 days, filtered, and the filtrate was concentrated to dryness to obtain 9.8 g of perilla ethanol extract. It was.
製造例１９ オウレンの熱水抽出物
黄連１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してオウレンの熱水抽出物を４．５ｇ得た。
Production Example 19 Hot Water Extract of Aureen 2 L of purified water was added to 100 g of Yellow Ren, extracted at 95-100 ° C. for 2 hours, filtered, and the filtrate was concentrated and lyophilized to obtain a hot water extract of Aureen. 4.5 g was obtained.
製造例２０ サイシンの熱水抽出物
ウスバサイシンの葉の１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してサイシンの熱水抽出物を４．０ｇ得た。
Production Example 20 Hot Water Extract of Saisin 2 L of purified water was added to 100 g of the leaves of Usuba Saisin, extracted at 95-100 ° C. for 2 hours, filtered, the filtrate was concentrated, freeze-dried, and hot water of Saisin 4.0 g of extract was obtained.
製造例２１ サイシンのエタノール抽出物
細辛５０ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固し、サイシンのエタノール抽出物を７．２ｇ得た。
Production Example 21 Ethylene extract of saicin 1 L of ethanol was added to 50 g of fine spices, extracted at room temperature for 7 days, filtered, and the filtrate was concentrated to dryness to obtain 7.2 g of ethanol extract of saicin.
製造例２２ コガネバナの５０％１，３−ブチレングリコール水溶液抽出物
コガネバナの葉および茎の乾燥物２０ｇに精製水２００ｍＬおよび１，３−ブチレングリコール２００ｍＬを加え、常温で7日間抽出した後、濾過し、コガネバナの５０％１，３−ブチレングリコール抽出物を３２０ｇ得た。
Production Example 22 Extract of 50% 1,3-butylene glycol aqueous solution of Koganebana 200 mL of purified water and 200 mL of 1,3-butylene glycol were added to 20 g of dried leaves and stems of Koganebana, extracted for 7 days at room temperature, and then filtered. 320 g of 50% 1,3-butylene glycol extract of Koganebana was obtained.
製造例２３ コガネバナの熱水抽出物
黄ごん１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してコガネバナの熱水抽出物を４．１ｇ得た。
Production Example 23 Hot Water Extract of Koganebana Add 2 L of purified water to 100 g of yellow rice, extract at 95-100 ° C. for 2 hours, filter, concentrate the filtrate, freeze-dry and extract hot water extract of Koganebana 4.1g was obtained.
製造例２４ キハダの熱水抽出物
キハダの根の乾燥物１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してキハダの熱水抽出物を３．９ｇ得た。
Production Example 24 Yellow Hot Water Extract of Yellowfin Addition of 2 L of purified water to 100 g of dried yellowfin root, extracted at 95-100 ° C. for 2 hours, filtered, concentrated, lyophilized and freeze-dried. 3.9 g of water extract was obtained.
製造例２５ キハダのエタノール抽出物
黄柏１００ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固し、キハダのエタノール抽出物を７．６ｇ得た。
Production Example 25 Yellow extract of yellowfin 1 lL of ethanol was added to 100 g of jaundice and extracted at room temperature for 7 days, followed by filtration. The filtrate was concentrated to dryness to obtain 7.6 g of yellowfin ethanol extract.
製造例２６ クワの熱水抽出物
ヤマグワの根の乾燥物１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してクワの熱水抽出物を４．０ｇ得た。
Production Example 26 Mulberry Hot Water Extract 2 L of purified water was added to 100 g of dried maggot root, extracted at 95-100 ° C. for 2 hours, filtered, the filtrate was concentrated, lyophilized and mulberry heat 4.0 g of water extract was obtained.
製造例２７ クワのエタノール抽出物
桑白皮１００ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固し、クワのエタノール抽出物を５．１ｇ得た。
Production Example 27 Mulberry ethanol extract 1 L of ethanol was added to 100 g of mulberry white skin, extracted at room temperature for 7 days, filtered, and the filtrate was concentrated to dryness to obtain 5.1 g of mulberry ethanol extract.
製造例２８ ボタンの熱水抽出物
ボタンの葉の乾燥物１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してボタンの熱水抽出物を３．５ｇ得た。
Production Example 28 Hot Water Extract of Button 2 L of purified water was added to 100 g of dried button leaf, extracted at 95-100 ° C. for 2 hours, filtered, and the filtrate was concentrated and freeze-dried to heat the button. 3.5 g of water extract was obtained.
製造例２９ ボタンの５０％１，３−ブチレングリコール水溶液抽出物
牡丹皮２０ｇに精製水２００ｍＬおよび１，３−ブチレングリコール２００ｍＬを加え、常温で7日間抽出した後、濾過し、ボタンの５０％１，３−ブチレングリコール抽出物を３７０ｇ得た。
Production Example 29 Extract from 50% 1,3-butylene glycol aqueous solution of button Add 200 mL of purified water and 200 mL of 1,3-butylene glycol to 20 g of peony skin, extract at room temperature for 7 days, filter, and filter 50% 1 of button , 3-butylene glycol extract was obtained.
製造例３０ シャクヤクの熱水抽出物
芍薬１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してシャクヤクの熱水抽出物を３．９ｇ得た。
Production Example 30 Peonies hot water extract 2 L of purified water was added to 100 g of glaze, extracted at 95-100 ° C. for 2 hours, filtered, and the filtrate was concentrated and freeze-dried to obtain 3 peonies hot water extract. .9 g was obtained.
製造例３１ チンピの熱水抽出物
ウンシュウミカンの葉および茎の乾燥物１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してチンピの熱水抽出物を３．１ｇ得た。
Production Example 31 Hot Water Extract of Chinpi Add 2 L of purified water to 100 g of dried leaves and stems of Citrus unshiu, extract at 95-100 ° C. for 2 hours, filter, concentrate the filtrate and freeze-dry it. 3.1 g of hot water extract of chimpi was obtained.
製造例３２ チンピのエタノール抽出物
陳皮１００ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固し、チンピのエタノール抽出物を４．５ｇ得た。
Production Example 32 Ethylic extract of Chinpi 1 L of ethanol was added to 100 g of skin and extracted at room temperature for 7 days, followed by filtration. The filtrate was concentrated to dryness to obtain 4.5 g of Chinpi ethanol extract.
製造例３３ ムクロジのエタノール抽出物
ムクロジ果皮の乾燥物１００ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固し、ムクロジのエタノール抽出物を４．４ｇ得た。
Production Example 33 Ethanol Extract of Mukuroji 1 L of ethanol was added to 100 g of dried mukuroji peel and extracted at room temperature for 7 days, followed by filtration. The filtrate was concentrated to dryness to obtain 4.4 g of an extract of mukuroji. .
製造例３４ チョウジの熱水抽出物
丁字１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してチョウジの熱水抽出物を５．２ｇ得た。
Production Example 34 Hot Water Extract of Clove Add 2 L of purified water to 100 g of clove, extract at 95-100 ° C. for 2 hours, filter, concentrate the filtrate and freeze-dry to obtain 5 hot water extract of clove. 0.2 g was obtained.
製造例３５ ユリの５０％１，３−ブチレングリコール水溶液抽出物
マドンナリリーの球根の乾燥物２０ｇに精製水２００ｍＬおよび１，３−ブチレングリコール２００ｍＬを加え、常温で7日間抽出した後、濾過し、ユリの５０％１，３−ブチレングリコール抽出物を３２０ｇ得た。
Production Example 35 Lily 50% 1,3-butylene glycol aqueous solution extract To 20 g of dried Madonna lily bulbs, 200 mL of purified water and 200 mL of 1,3-butylene glycol were added, extracted at room temperature for 7 days, filtered, 320 g of a lily 50% 1,3-butylene glycol extract was obtained.
製造例３６ ダイズのエタノール抽出物
ダイズの葉の乾燥物１００ｇにエタノール１Ｌを加え、常温で7日間抽出した後、濾過し、その濾液を濃縮乾固し、ダイズのエタノール抽出物を４．２ｇ得た。
Production Example 36 Ethanol Extract of Soybean 1 L of ethanol was added to 100 g of dried soybean leaves, extracted at room temperature for 7 days, filtered, and the filtrate was concentrated to dryness to obtain 4.2 g of soybean ethanol extract. It was.
製造例３７ ダイズの熱水抽出物
ダイズの種子１００ｇに精製水２Ｌを加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してダイズの熱水抽出物を５．０ｇ得た
Production Example 37 Soybean hot water extract 2 L of purified water was added to 100 g of soybean seeds, extracted at 95-100 ° C. for 2 hours, filtered, and the filtrate was concentrated and freeze-dried to obtain a hot water extract of soybeans. 5.0g was obtained
製造例３８ シロキクラゲの熱水抽出物
シロキクラゲの子実体の乾燥物２０ｇに４Ｌの精製水を加え、９５〜１００℃で２時間抽出した後、濾過し、その濾液を濃縮し、凍結乾燥してシロキクラゲの熱水抽出物を１．５ｇ得た。
Manufacture example 38 Hot water extract of white jellyfish 4 L of purified water was added to 20 g of dried fruit body of white jellyfish, extracted at 95-100 ° C. for 2 hours, filtered, and the filtrate was concentrated, lyophilized and dried. 1.5 g of a hot water extract was obtained.
処方例１ クリーム１
処方 配合量
１．クズのエタノール抽出物（製造例４） １．０部
２．スクワラン ５．５
３．オリーブ油 ３．０
４．ステアリン酸 ２．０
５．ミツロウ ２．０
６．ミリスチン酸オクチルドデシル ３．５
７．ポリオキシエチレンセチルエーテル（２０Ｅ．Ｏ．） ３．０
８．ベヘニルアルコール １．５
９．モノステアリン酸グリセリン ２．５
１０．香料 ０．１
１１．１，３−ブチレングリコール ８．５
１２．パラオキシ安息香酸エチル ０．０５
１３．パラオキシ安息香酸メチル ０．２
１４．精製水 ６７．１５
［製造方法］成分２〜９を加熱溶解して混合し、７０℃に保ち油相とする。成分１および１１〜１４を加熱溶解して混合し、７５℃に保ち水相とする。油相に水相を加えて乳化して、かき混ぜながら冷却し、４５℃で成分１０を加え、更に３０℃まで冷却して製品とする。
Formulation Example 1 Cream 1
Formulation Formulation 1. Waste ethanol extract (Production Example 4) 1.0 part Squalane 5.5
3. Olive oil 3.0
4). Stearic acid 2.0
5. Beeswax 2.0
6). Octyldodecyl myristate 3.5
7). Polyoxyethylene cetyl ether (20E.O.) 3.0
8). Behenyl alcohol 1.5
9. Glycerol monostearate2.5
10. Fragrance 0.1
11.1,3-butylene glycol 8.5
12 Ethyl paraoxybenzoate 0.05
13. Methyl paraoxybenzoate 0.2
14 Purified water 67.15
[Manufacturing method] Components 2 to 9 are heated and dissolved and mixed, and kept at 70 ° C to obtain an oil phase. Ingredients 1 and 11 to 14 are dissolved by heating and mixed, and kept at 75 ° C. to obtain an aqueous phase. The aqueous phase is added to the oil phase to emulsify, and the mixture is cooled while stirring. The component 10 is added at 45 ° C, and further cooled to 30 ° C to obtain a product.
処方例２ クリーム２
処方 配合量
１．シロキクラゲの熱水抽出物（製造例３８） １．０部
２．シソのエタノール抽出物（製造例１８） １．０
３．スクワラン ５．５
４．オリーブ油 ３．０
５．ステアリン酸 ２．０
６．ミツロウ ２．０
７．ミリスチン酸オクチルドデシル ３．５
８．ポリオキシエチレンセチルエーテル（２０Ｅ．Ｏ．） ３．０
９．ベヘニルアルコール １．５
１０．モノステアリン酸グリセリン ２．５
１１．香料 ０．１
１２．１，３−ブチレングリコール ８．５
１３．パラオキシ安息香酸エチル ０．０５
１４．パラオキシ安息香酸メチル ０．２
１５．精製水 ６６．１５
［製造方法］成分３〜１０を加熱溶解して混合し、７０℃に保ち油相とする。成分１および２と成分１２〜１５を加熱溶解して混合し、７５℃に保ち水相とする。油相に水相を加えて乳化して、かき混ぜながら冷却し、４５℃で成分１１を加え、更に３０℃まで冷却して製品とする。
Formulation Example 2 Cream 2
Formulation Formulation 1. 1.0 parts of hot water extract of white jellyfish (Production Example 38) Perilla ethanol extract (Production Example 18) 1.0
3. Squalane 5.5
4). Olive oil 3.0
5. Stearic acid 2.0
6). Beeswax 2.0
7). Octyldodecyl myristate 3.5
8). Polyoxyethylene cetyl ether (20E.O.) 3.0
9. Behenyl alcohol 1.5
10. Glycerol monostearate2.5
11. Fragrance 0.1
12.1,3-Butylene glycol 8.5
13. Ethyl paraoxybenzoate 0.05
14 Methyl paraoxybenzoate 0.2
15. Purified water 66.15
[Manufacturing method] Components 3 to 10 are dissolved by heating and mixed, and kept at 70 ° C to obtain an oil phase. Ingredients 1 and 2 and ingredients 12-15 are dissolved by heating and mixed, and kept at 75 ° C. to form an aqueous phase. The aqueous phase is added to the oil phase to emulsify, and the mixture is cooled while stirring.
処方例３ クリーム３
処方例１において、クズのエタノール抽出物を、オウレンの熱水抽出物（製造例１９）に置き換えたものをクリーム３とした。
Formulation Example 3 Cream 3
In Formulation Example 1, cream 3 was obtained by replacing the ethanol extract of kudzu with the hot water extract of auren (Production Example 19).
比較例１ 従来のクリーム
処方例１において、クズのエタノール抽出物を精製水に置き換えたものを従来のクリームとした。
Comparative Example 1 Conventional Cream A conventional cream was prepared by replacing the ethanol extract of kudzu with purified water in Formulation Example 1.
処方例４ 化粧水１
処方 配合量
１．キハダのエタノール抽出物（製造例２５） ０．１部
２．１，３−ブチレングリコール ８．０
３．グリセリン ２．０
４．キサンタンガム ０．０２
５．クエン酸 ０．０１
６．クエン酸ナトリウム ０．１
７．エタノール ５．０
８．パラオキシ安息香酸メチル ０．１
９．ポリオキシエチレン硬化ヒマシ油（４０Ｅ．Ｏ．） ０．１
１０．香料 ０．１
１１．精製水 ８４．４７
［製造方法］成分２〜６および１１と、成分１および成分７〜１０をそれぞれ均一に溶解し、両者を混合し濾過して製品とする。
Formulation Example 4 Lotion 1
Formulation Formulation 1. Yellowfin ethanol extract (Production Example 25) 0.1 part 2.1,3-butylene glycol 8.0
3. Glycerin 2.0
4). Xanthan gum 0.02
5. Citric acid 0.01
6). Sodium citrate 0.1
7). Ethanol 5.0
8). Methyl paraoxybenzoate 0.1
9. Polyoxyethylene hydrogenated castor oil (40E.O.) 0.1
10. Fragrance 0.1
11. Purified water 84.47
[Manufacturing method] Components 2-6 and 11 and components 1 and 7-10 are uniformly dissolved, mixed and filtered to obtain a product.
処方例５ 化粧水２
処方例４において、キハダのエタノール抽出物を、アンズのエタノール抽出物（製造例６）に置き換えたものを化粧水２とした。
Formulation Example 5 Lotion 2
In Formulation Example 4, the lotion 2 was obtained by replacing yellowfin ethanol extract with apricot ethanol extract (Production Example 6).
処方例６ 化粧水３
処方例４において、キハダのエタノール抽出物を、スイカズラのエタノール抽出物（製造例８）に置き換えたものを化粧水３とした。
Formulation Example 6 Lotion 3
In Formulation Example 4, lotion 3 was obtained by replacing yellowfin ethanol extract with honeysuckle ethanol extract (Production Example 8).
処方例７ 化粧水４
処方例４において、キハダのエタノール抽出物を、ラフマのエタノール抽出物（製造例１１）に置き換えたものを化粧水４とした。
Formulation Example 7 Lotion 4
In Formulation Example 4, lotion 4 was obtained by replacing the ethanol extract of yellowfin with an ethanol extract of Rahuma (Production Example 11).
処方例８ 化粧水５
処方例４において、キハダのエタノール抽出物を、イザヨイバラのエタノール抽出物（製造例１４）に置き換えたものを化粧水５とした。
Formulation Example 8 Lotion 5
In Formulation Example 4, the lotion 5 was obtained by replacing the ethanol extract of yellowfin with an ethanol extract of Izayoi Rose (Production Example 14).
処方例９ 化粧水６
処方例４において、キハダのエタノール抽出物を、サイシンのエタノール抽出物（製造例２１）に置き換えたものを化粧水６とした。
Formulation Example 9 Lotion 6
In Formulation Example 4, lotion 6 was obtained by replacing the ethanol extract of yellowfin with an ethanol extract of Saicin (Production Example 21).
処方例１０ 化粧水７
処方例４において、キハダのエタノール抽出物を、ダイズのエタノール抽出物（製造例３６）に置き換えたものを化粧水７とした。
Formulation Example 10 Lotion 7
In Formulation Example 4, the lotion 7 was obtained by replacing the yellow extract of yellowfin with an ethanol extract of soybean (Production Example 36).
比較例２ 従来の化粧水
処方例４において、キハダのエタノール抽出物を精製水に置き換えたものを従来の化粧水とした。
Comparative Example 2 Conventional Lotion A conventional lotion was obtained by replacing the ethanol extract of yellowfin with purified water in Formulation Example 4.
処方例１１ 乳液１
処方 配合量
１．アンズのエタノール抽出物（製造例６） ０．５部
２．スクワラン ５．０
３．オリーブ油 ５．０
４．ホホバ油 ５．０
５．セタノール １．５
６．モノステアリン酸グリセリン ２．０
７．ポリオキシエチレンセチルエーテル（２０Ｅ．Ｏ．） ３．０
８．ポリオキシエチレンソルビタンモノオレエート（２０Ｅ．Ｏ．） ２．０
９．香料
０．１
１０．プロピレングリコール
１．０
１１．グリセリン
２．０
１２．パラオキシ安息香酸メチル
０．２
１３．精製水 ７２．７
［製造方法］成分２〜８を加熱溶解して混合し、７０℃に保ち油相とする。成分１および１０〜１３を加熱溶解して混合し、７５℃に保ち水相とする。油相に水相を加えて乳化して、かき混ぜながら冷却し、４５℃で成分９を加え、更に３０℃まで冷却して製品とする。
Formulation Example 11 Latex 1
Formulation Formulation 1. Apricot ethanol extract (Production Example 6) 0.5 part
2. Squalane 5.0
3. Olive oil 5.0
4). Jojoba oil 5.0
5. Cetanol 1.5
6). Glycerol monostearate 2.0
7). Polyoxyethylene cetyl ether (20E.O.) 3.0
8). Polyoxyethylene sorbitan monooleate (20E.O.) 2.0
9. Fragrance
0.1
10. Propylene glycol
1.0
11. Glycerin
2.0
12 Methyl paraoxybenzoate
0.2
13. Purified water 72.7
[Manufacturing method] Components 2 to 8 are dissolved by heating and mixed, and kept at 70 ° C to obtain an oil phase. Ingredients 1 and 10-13 are dissolved by heating and mixed, and kept at 75 ° C. to form an aqueous phase. The aqueous phase is added to the oil phase to emulsify, and the mixture is cooled while stirring.
処方例１２ 乳液２
処方例１１において、アンズのエタノール抽出物０．５部をスイカズラのエタノール抽出物（製造例８）０．２５部とナツメのエタノール抽出物（製造例１７）０．２５部に置き換えたものを乳液２とした。
Formulation Example 12 Emulsion 2
In Prescription Example 11, 0.5 parts of apricot ethanol extract was replaced with 0.25 parts of honeysuckle ethanol extract (Production Example 8) and 0.25 parts of jujube ethanol extract (Production Example 17). 2.
処方例１３ ゲル剤
処方 配合量
１．サイシンのエタノール抽出物（製造例２１） １．０部
２．エタノール ５．０
３．パラオキシ安息香酸メチル ０．１
４．ポリオキシエチレン硬化ヒマシ油（６０Ｅ．Ｏ．） ０．１
５．香料 ０．０５
６．１，３−ブチレングリコール ５．０
７．グリセリン ５．０
８．キサンタンガム ０．１
９．カルボキシビニルポリマー ０．２
１０．水酸化カリウム ０．２
１１．精製水 ８３．２５
［製造方法］成分２〜５と、成分１および６〜１１をそれぞれ均一に溶解し、両者を混合して製品とする。
Formulation Example 13 Gel agent Formulation Formulation amount 1. 1. Ethanol extract of saicin (Production Example 21) 1.0 part Ethanol 5.0
3. Methyl paraoxybenzoate 0.1
4). Polyoxyethylene hydrogenated castor oil (60 EO) 0.1
5. Fragrance 0.05
6.1,3-Butylene glycol 5.0
7). Glycerin 5.0
8). Xanthan gum 0.1
9. Carboxyvinyl polymer 0.2
10. Potassium hydroxide 0.2
11. Purified water 83.25
[Manufacturing method] Components 2 to 5 and components 1 and 6 to 11 are uniformly dissolved and mixed to obtain a product.
処方例１４ パック
処方 配合量
１．コメのエタノール抽出物（製造例２） ０．１部
２．クワのエタノール抽出物（製造例２７） ０．１
３．ポリビニルアルコール １２．０
４．エタノール ５．０
５．１，３−ブチレングリコール ８．０
６．パラオキシ安息香酸メチル ０．２
７．ポリオキシエチレン硬化ヒマシ油（２０Ｅ．Ｏ．） ０．５
８．クエン酸 ０．１
９．クエン酸ナトリウム ０．３
１０．香料 ０．０５
１１．精製水 ７３．６５
［製造方法］成分１〜１１を均一に溶解し製品とする。
Formulation Example 14 Pack Formulation Formulation 1. Rice ethanol extract (Production Example 2) 0.1 part Mulberry ethanol extract (Production Example 27) 0.1
3. Polyvinyl alcohol 12.0
4). Ethanol 5.0
5.1,3-Butylene glycol 8.0
6). Methyl paraoxybenzoate 0.2
7). Polyoxyethylene hydrogenated castor oil (20 EO) 0.5
8). Citric acid 0.1
9. Sodium citrate 0.3
10. Fragrance 0.05
11. Purified water 73.65
[Production Method] Components 1 to 11 are uniformly dissolved to obtain a product.
処方例１５ ファンデーション
処方 配合量
１．テンチャのエタノール抽出物（製造例１０） ０．５部
２．イザヨイバラのエタノール抽出物（製造例１４） ０．５
３．ステアリン酸 ２．４
４．ポリオキシエチレンソルビタンモノステアレート
（２０Ｅ．Ｏ．） １．０
５．ポリオキシエチレンセチルエーテル（２０Ｅ．Ｏ．） ２．０
６．セタノール １．０
７．液状ラノリン ２．０
８．流動パラフィン ３．０
９．ミリスチン酸イソプロピル ６．５
１０．カルボキシメチルセルロースナトリウム ０．１
１１．ベントナイト ０．５
１２．プロピレングリコール ４．０
１３．トリエタノールアミン １．１
１４．パラオキシ安息香酸メチル ０．２
１５．二酸化チタン ８．０
１６．タルク ４．０
１７．ベンガラ １．０
１８．黄酸化鉄 ２．０
１９．香料 ０．１
２０．精製水 ６０．１
［製造方法］成分３〜８を加熱溶解し、８０℃に保ち油相とする。成分２０に成分１０をよく膨潤させ、続いて、成分１，２および成分１２〜１４を加えて均一に混合する。これに粉砕機で粉砕混合した成分１５〜１８を加え、ホモミキサーで撹拌し７５℃に保ち水相とする。この水相に油相をかき混ぜながら加え、冷却し、４５℃で成分１９を加え、かき混ぜながら３０℃まで冷却して製品とする。
Formulation Example 15 Foundation Formulation Formulation amount 1. Tencha ethanol extract (Production Example 10) 0.5 part Isaiyoibara ethanol extract (Production Example 14) 0.5
3. Stearic acid 2.4
4). Polyoxyethylene sorbitan monostearate (20EO) 1.0
5. Polyoxyethylene cetyl ether (20E.O.) 2.0
6). Cetanol 1.0
7). Liquid lanolin 2.0
8). Liquid paraffin 3.0
9. Isopropyl myristate 6.5
10. Sodium carboxymethylcellulose 0.1
11. Bentonite 0.5
12 Propylene glycol 4.0
13. Triethanolamine 1.1
14 Methyl paraoxybenzoate 0.2
15. Titanium dioxide 8.0
16. Talc 4.0
17. Bengala 1.0
18. Yellow iron oxide 2.0
19. Fragrance 0.1
20. Purified water 60.1
[Manufacturing method] Components 3 to 8 are dissolved by heating and kept at 80 ° C to form an oil phase. Swell component 10 well in component 20, then add components 1, 2 and 12-14 and mix uniformly. To this, components 15 to 18 pulverized and mixed with a pulverizer are added, and the mixture is stirred with a homomixer and kept at 75 ° C. to obtain an aqueous phase. The oily phase is added to the aqueous phase with stirring, cooled, and component 19 is added at 45 ° C, and cooled to 30 ° C with stirring to give a product.
処方例１６ 軟膏
処方 配合量
１．ラフマのエタノール抽出物（製造例１１） ０．０１部
２．ボタンの５０％１，３−ブチレングリコール抽出物（製造例２９） ０．５
３．ポリオキシエチレンセチルエーテル（３０Ｅ．Ｏ．） ２．０
４．モノステアリン酸グリセリン １０．０
５．流動パラフィン ５．０
６．セタノール ６．０
７．パラオキシ安息香酸メチル ０．１
８．プロピレングリコール １０．０
９．精製水 ６６．３９
［製造方法］成分３〜６を加熱溶解して混合し、７０℃に保ち油相とする。成分１、２および７〜９を加熱溶解して混合し、７５℃に保ち水相とする。油相に水相を加えて乳化して、かき混ぜながら３０℃まで冷却して製品とする。
Formulation Example 16 Ointment Formulation Formulation 1. Raffma ethanol extract (Production Example 11) 0.01 part 50% 1,3-butylene glycol extract of button (Production Example 29) 0.5
3. Polyoxyethylene cetyl ether (30E.O.) 2.0
4). Glycerol monostearate 10.0
5. Liquid paraffin 5.0
6). Cetanol 6.0
7). Methyl paraoxybenzoate 0.1
8). Propylene glycol 10.0
9. Purified water 66.39
[Production Method] Components 3 to 6 are dissolved by heating and mixed, and kept at 70 ° C. to obtain an oil phase. Ingredients 1, 2 and 7-9 are dissolved by heating and mixed, and kept at 75 ° C. to form an aqueous phase. The aqueous phase is added to the oil phase to emulsify, and the mixture is cooled to 30 ° C. with stirring to obtain a product.
処方例１７ 飲料
処方 配合量
１．コガネバナの熱水抽出物（製造例２３） １．０部
２．ステビア ０．０５
３．リンゴ酸 ５．０
４．香料 ０．１
５．水 ９３．８５
［製造方法］成分２および３を少量の水に溶解する。次いで、成分１および４、５を加えて混合する。
Formulation Example 17 Beverage Formulation Formulation 1. 1. Hot water extract of Koganebana (Production Example 23) 1.0 part Stevia 0.05
3. Malic acid 5.0
4). Fragrance 0.1
5. Water 93.85
[Production Method] Components 2 and 3 are dissolved in a small amount of water. Components 1 and 4, 5 are then added and mixed.
処方例１８ 錠剤
処方 配合量
１．ムクロジのエタノール抽出物（製造例３３） １０．０部
２．トウモロコシデンプン １０．０
３．精製白糖 ２０．０
４．カルボキシメチルセルロース １０．０
５．微結晶セルロース ３５．０
６．ポリビニルピロリドン ５．０
７．タルク １０．０
［製造方法］成分１〜５を混合し、次いで成分６の水溶液を結合剤として加えて常法により顆粒化した。これに滑沢剤として成分７を加えて配合した後、１錠１００ｍｇの錠剤に打錠した。
Formulation Example 18 Tablet Formulation Formulation 1. Mukuroji ethanol extract (Production Example 33) 10.0 parts Corn starch 10.0
3. Purified white sugar 20.0
4). Carboxymethylcellulose 10.0
5. Microcrystalline cellulose 35.0
6). Polyvinylpyrrolidone 5.0
7). Talc 10.0
[Production Method] Components 1 to 5 were mixed, and then an aqueous solution of Component 6 was added as a binder and granulated by a conventional method. This was mixed with ingredient 7 as a lubricant and then tableted into 100 mg tablets.
次に、本発明の効果を詳細に説明するため、実験例を挙げる。 Next, experimental examples will be given to explain the effects of the present invention in detail.
実験例１ セラミド合成促進試験
マウスケラチノサイト由来細胞株であるＰａｍ２１２細胞を６ｃｍディッシュに１×１０５個播種し、４日間培養した。その後、試料を最終濃度が固形物として１０μｇ／ｍＬになるように添加し、さらに２４時間培養を続けた。次に細胞をＰＢＳ（−）にて３回洗浄した後、ラバーポリスマンにて集め、凍結乾燥した。クロロホルム：メタノール（２：１）１ｍＬにて細胞から脂質を抽出し、その中のセラミド量をＫｉｓｉｃらの蛍光法（Ｋｉｓｉｃ Ａ. ａｎｄ Ｒａｐｐｏｒｔ Ｍ．Ｍ．， Ｊｏｕｒｎａｌ ｏｆ Ｌｉｐｉｄ Ｒｅｓｅａｒｃｈ， １５， １７９−１８０ （１９７４））により測定した。すなわち、脂質を３Ｎ塩酸０．１５ｍＬにて１００℃で２時間加水分解し、デシケーター中で乾燥、塩酸除去した後、酢酸エチル２ｍＬと０．１Ｍ酢酸緩衝液（ｐＨ３．７）１．２５ｍＬを加え、よく撹拌した。次に、フルオレスカミン溶液（フルオレスカミン ７ｍｇ／２５ｍＬ アセトン）０．２５ｍＬを加え、よく撹拌した後、遠心分離し、酢酸エチル層の蛍光強度をＥｘ４１０ｎｍ、Ｅｍ４９０ｎｍにて測定した。試料未添加のセラミド合成量をコントロールとし、コントロールを１００としたときの試料添加時のセラミド合成量の値をセラミドの合成促進率とした。
Experimental Example 1 Ceramide Synthesis Promotion Test 1 × 10 5 Pam212 cells, a mouse keratinocyte-derived cell line, were seeded in a 6 cm dish and cultured for 4 days. Thereafter, the sample was added to a final concentration of 10 μg / mL as a solid, and the culture was further continued for 24 hours. Next, the cells were washed three times with PBS (−), collected by a rubber policeman, and lyophilized. Lipids were extracted from cells with 1 mL of chloroform: methanol (2: 1), and the amount of ceramide in the cells was determined by the fluorescence method of Kisic et al. (Kisic A. and Rapport MM, Journal of Lipid Research, 15, 179-180. (1974)). That is, the lipid was hydrolyzed with 0.15 mL of 3N hydrochloric acid at 100 ° C. for 2 hours, dried in a desiccator, removed with hydrochloric acid, and then added with 2 mL of ethyl acetate and 1.25 mL of 0.1 M acetate buffer (pH 3.7). Stir well. Next, 0.25 mL of a fluorescamine solution (fluorescamine 7 mg / 25 mL acetone) was added, stirred well, then centrifuged, and the fluorescence intensity of the ethyl acetate layer was measured at Ex 410 nm and Em 490 nm. The amount of ceramide synthesis with no sample added was defined as the control, and the value of the amount of ceramide synthesized when the sample was added when the control was 100 was defined as the ceramide synthesis acceleration rate.
これらの実験結果を表１に示した。その結果、コメ、クズ、アンズ、スイカズラ、ユキノシタ、テンチャ、ラフマ、サンザシ、イザヨイバラ、エゾウコギ、ナツメ、シソ、オウレン、サイシン、コガネバナ、キハダ、クワ、ボタン、シャクヤク、チンピ、ムクロジ、チョウジ、ユリ、ダイズおよびシロキクラゲの抽出物は、コントロールと比較して優れたセラミド合成促進効果を示した。 The results of these experiments are shown in Table 1. As a result, rice, kudzu, apricot, honeysuckle, snow flakes, tencha, rafma, hawthorn, izayoi rose, elephant kogi, jujube, perilla, auren, saishin, koganebana, kihada, mulberry, button, peonies, chimpi, mukuroji, clove, clove, lily, soybean And the extract of white jellyfish showed an excellent ceramide synthesis promoting effect compared with the control.
コメ、クズ、アンズ、スイカズラ、ユキノシタ、テンチャ、ラフマ、サンザシ、イザヨイバラ、エゾウコギ、ナツメ、シソ、オウレン、サイシン、コガネバナ、キハダ、クワ、ボタン、シャクヤク、チンピ、ムクロジ、チョウジ、ユリ、ダイズおよびシロキクラゲの抽出物から選ばれる2種以上の混合物についても同様にセラミド合成促進試験を行ったところ、優れたセラミド合成促進効果を示した。 Rice, Kudzu, Apricot, Honeysuckle, Snowflake, Tencha, Rafuma, Hawthorn, Izayoi Rose, Ezocogi, Jujube, Perilla, Ouren, Saishin, Koganebana, Yellowfin, Mulberry, Button, Peonies, Chimpi, Mukuroji, Clove, Lily, Soybean When a mixture of two or more selected from the extracts was subjected to the same ceramide synthesis promotion test, it showed an excellent ceramide synthesis promotion effect.
実験例２ 使用試験１
処方例４〜１０の化粧水、比較例２の従来の化粧水を用いて、肌荒れ、乾燥肌に悩む女性３０人（１８才〜５０才）を対象に１ヶ月間の使用試験を行った。使用後、肌荒れ、乾燥肌の改善作用をアンケートにより判定した。
Experiment 2 Use test 1
Using the skin lotions of Formulation Examples 4 to 10 and the conventional skin lotion of Comparative Example 2, a 1 month use test was conducted on 30 women (18 to 50 years old) who suffer from rough skin and dry skin. After use, the improvement effect of rough skin and dry skin was determined by questionnaire.
これらの試験結果を表２に示した。その結果、その結果、処方例４〜１０で得られる化粧水は、比較例２で得られる従来の化粧水よりも、肌荒れ、乾燥肌の予防改善効果に優れていた。なお、試験期間中、皮膚トラブルは一人もなく、安全性においても問題なかった。 The test results are shown in Table 2. As a result, the lotion obtained in Formulation Examples 4 to 10 was superior to the conventional lotion obtained in Comparative Example 2 in the effect of preventing and improving rough skin and dry skin. During the test period, there was no skin problem and there was no problem with safety.
製造例１から製造例３８に示される抽出物から選ばれる１種又は２種以上を含有するその他の化粧水についても使用試験を行ったところ、安全であり、優れた肌荒れ、乾燥肌の改善効果を示した。 When other use lotions containing one or more selected from the extracts shown in Production Example 1 to Production Example 38 were used, they were safe and had excellent rough skin and dry skin. showed that.
実験例３ 使用試験２
処方例１〜３のクリーム、比較例１の従来のクリームを用いて、肌荒れ、乾燥肌に悩む女性３０人（１８〜５０才）を対象に２ヶ月間の使用試験を行った。使用後、肌荒れ、乾燥肌の改善作用をアンケートにより判定した。
Experiment 3 Use test 2
Using the creams of Formulation Examples 1 to 3 and the conventional cream of Comparative Example 1, a use test for 2 months was conducted on 30 women (18 to 50 years old) who suffer from rough skin and dry skin. After use, the improvement effect of rough skin and dry skin was determined by questionnaire.
これらの試験結果を表３に示した。その結果、処方例１〜３で得られるクリームは、比較例１で得られる従来のクリームよりも、肌荒れ、乾燥肌の予防改善効果に優れていた。なお、試験期間中、皮膚トラブルは一人もなく、安全性においても問題なかった。また、処方成分の劣化についても問題なかった。 The test results are shown in Table 3. As a result, the creams obtained in Formulation Examples 1 to 3 were superior to the conventional cream obtained in Comparative Example 1 in the effect of preventing and improving rough skin and dry skin. During the test period, there was no skin problem and there was no problem with safety. There was also no problem with the deterioration of the prescription ingredients.
処方例１１〜１８についても使用試験を行ったところ、安全であり、優れた肌荒れ、乾燥肌の予防改善作用を示した。 When a usage test was conducted on Formulation Examples 11 to 18 as well, it was safe and exhibited excellent rough skin and a preventive and improving action on dry skin.
本発明のコメ、クズ、アンズ、スイカズラ、ユキノシタ、テンチャ、ラフマ、サンザシ、イザヨイバラ、エゾウコギ、ナツメ、シソ、オウレン、サイシン、コガネバナ、キハダ、クワ、ボタン、シャクヤク、チンピ、ムクロジ、チョウジ、ユリ、ダイズおよびシロキクラゲの抽出物から選ばれる1種又は2種以上は優れたセラミド合成促進剤として用いることが出来る。また、安全で肌荒れ、乾燥肌の改善効果に優れた組成物を提供できる。
Rice, crumbs, apricots, honeysuckle, marsh, tencha, rafma, hawthorn, izayoibara, ezokogi, jujube, perilla, lauren, saishin, koganebana, kihada, mulberry, button, peonies, chimpi, mukuroji, choji, lily, soybean One or two or more selected from the extract of white jellyfish can be used as an excellent ceramide synthesis accelerator. In addition, it is possible to provide a composition that is safe, rough, and excellent in improving dry skin.
Claims (2)
A composition excellent in the effect of preventing or improving rough skin and dry skin, comprising the ceramide synthesis accelerator according to claim 1.
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