JP2006096669A - Skin-beautifying composition - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin-beautifying composition exhibiting high skin-beautifying effect and preventing aging symptoms of skin such as wrinkle, slackness and chapped skin. <P>SOLUTION: The skin-beautifying composition comprises moray and/or its extract. External preparations and foods and beverages are obtained by using the composition. The composition can be applied to cosmetics, quasi-drugs, medicines, foods, health foods and functional foods. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to a beautifying skin-derived composition applied to cosmetics, quasi drugs, pharmaceuticals, foods and drinks, and the like.

  Skin troubles such as rough skin and fine lines are particularly serious problems for women. In skin tissue, acidic mucopolysaccharides such as hyaluronic acid and chondroitin sulfate, and proteins such as collagen and elastin are known as components that are largely involved in water retention and elasticity.

  The acidic mucopolysaccharide has high water retention, binds to collagen that plays the role of the matrix of the intercellular substance matrix, and is distributed in connective tissue, cartilage tissue, skin tissue, etc. Helps to maintain. If these amounts are reduced due to aging, ultraviolet rays, etc., the water retention and elasticity of the skin are lost, which causes rough skin and fine lines.

  Therefore, in order to prevent and improve rough skin and fine lines, it is important to maintain the moisture and tension of the skin.

  Conventionally, cosmetics and beauty health foods containing various ingredients having an effect of maintaining skin moisture and elasticity have been commercially available. Examples of such components include mucopolysaccharides such as hyaluronic acid and chondroitin sulfate described above, proteins such as collagen, low molecular sugars such as trehalose and sorbitol, vitamins, amino acid derivatives, ceramide, α-oryzanol, and purification. Examples include oils and fats such as camellia oil, and recently, there is a tendency to respect highly safe and naturally derived ingredients.

  Specifically, beauty and health food (see Patent Document 1) characterized by containing mucopolysaccharides containing hyaluronic acid and chondroitin sulfate, collagen and nucleic acid, improving active oxygen scavenging factor, antiallergic factor, skin, etc. Processed foods (see Patent Document 2) containing a mixture of two or more of food materials having factors and antioxidant factors (see Patent Document 2), foods composed of conchiolin or processed products thereof (see Patent Document 3), mucopolysaccharides and peptides Health foods having complex mucopolysaccharides bound to each other (see Patent Document 4), health foods containing ceramide (see Patent Document 5), and the like.

JP-A-10-165138 JP 10-000070 A JP-A-8-173091 JP-A-9-98739 JP-A-11-113530

  An object of the present invention is to provide a skin-beautifying composition that exhibits a high skin-beautifying effect and prevents skin aging symptoms such as wrinkles, sagging, and rough skin.

  Under such circumstances, the present inventor has conducted extensive research, and as a result, by taking the moray eel and / or extract thereof orally or transdermally, it exhibits a high skin-beautifying effect, and skin aging symptoms such as wrinkles, sagging, and rough skin The present invention has been completed.

  Moray eels were unusual in appearance, had many bones, and were difficult to cook, so that they were rarely used for food except in some areas.

  In the present invention, a moray eel and / or an extract thereof is taken orally or transdermally to exhibit a high skin-beautifying effect and prevent skin aging symptoms such as wrinkles, sagging and rough skin.

The moray used in the present invention is not particularly limited as long as it is a fish of Muraenidae . Specifically, Arashiutsubo genus (Echidna) Kumoutsubo (Echidna nebulosa), striped Arashi eels (Echidna polyzona), tears Waka eels (Echidna rhodochilus), Arashiutsubo (Echidna delicatula), Ensherikore genus (Enchelycore) Kokeutsubo (Enchelycore lichenosa), Hidautsubo (Enchelycore schismatorhynchus), zebra moray species (Gymnomuraena) zebra moray (Gymnomuraena zebra), Torautsubo genus (Muraena) Torautsubo (Muraena pardalis), moray eels belonging to the genus (Gymnothorax) Herishiroutsubo (Gymnothorax albimarginatus), Hawaii moray eels (Gymnothorax berndti), Wakautsubo (Gymnothorax eurostus) , Herigoishiutsubo (Gymnothorax fimbriatus), Gomautsubo (Gymnothorax. flavimarginatus), giant moray (Gymnothorax javanicus), moray eels (Gymnothorax kidako), Yuriutsubo (Gymnothorax leucostigmus), Nisegoishiutsubo (Gy mnothorax melanospilus), Hanabirautsubo (Gymnothorax meleagris), Adeutsubo (Gymnothorax nudivomer), Amimeutsubo (Gymnothorax pseudothyrsoideus), Amiutsubo (Gymnothorax reticularis), Mobautsubo (Gymnothorax richardsoni), Sabiutsubo (Gymnothorax thyrsoideus), Namiutsubo (Gymnothorax undulatus), Hireobiutsubo (Gymnothorax zonipectis), Yamiutsubo (Gymnothorax monochrous), Aseutsubo (Gymnothorax pictus), Kurakakeutsubo (Gymnothorax rueppelliae), honey comb moray eels (Gymnothorax favagineus), ribbon eel species (Rhinomuraena) ribbon eel (Rhinomuraena quaesita), moray eels belonging to the Pusoidoshidona genus (Pseudechidna), Sutorofidon genus (Strophidon) pattern bamboo moray eels (Strophidon brummeri), belonging to the genus Monopenkerisu (Monopenchelys) moray eels, Enkerinassa genus (Ench moray eels belonging to the elynassa), moray eels belonging to the Shiderea genus (Siderea), moray eels belonging to the Chirusoidea genus (Thyrsoidea), Sukuchikaria genus (Scuticaria) Bandedomorei (Scuticaria okinawae), Tiger mode Rei (Scuticaria tigrina), Uroputerijiusu genus (Uropterygius) pattern Machinery moray eel ( Uropterygius tigrina ), moray eels belonging to the genus Anarchias , moray eels belonging to the genus Channomuraena , etc. These morays are known to be poisonous, but can be used except for toxic sites or components. Among the above-mentioned morays , it is particularly preferable to use a moray ( Gymnothorax kidako ) from the viewpoint of supply of raw materials and safety.

  The use part of the moray in the skin beautifying composition of the present invention is not particularly limited, and one or two or more parts selected from the whole or each part of bone, skin, fruit, scale, fin, heel, and viscera are used. be able to.

  In the composition for beautifying skin of the present invention, the collected crucible may be used as it is, but may be dried for ease of processing. Moreover, you may use what was extracted with the solvent with the raw | natural or dried thing.

  The method for drying the moray is not particularly limited, and it can be dried by a method such as sun drying, heat drying, etc., but it is preferable to dry using a freeze-drying method that can be dried while retaining the content components. .

  A method for extracting from a moray using a solvent will be described below, but is not limited to these extraction solvents and extraction methods. As an extraction solvent, water, ethanol, methanol, isopropanol, isobutanol, n-hexanol, methyl amyl alcohol, 2-ethylbutanol, n-octyl alcohol and other alcohols, glycerin, ethylene glycol, ethylene glycol monomethyl ether, ethylene glycol Polyethyl alcohol such as monoethyl ether, propylene glycol, propylene glycol monomethyl ether, propylene glycol monoethyl ether, triethylene glycol, 1,3-butylene glycol, hexylene glycol or derivatives thereof, acetone, methyl ethyl ketone, methyl isobutyl ketone, methyl -Ketones such as n-propyl ketone, esters such as ethyl acetate and isopropyl acetate, ethyl ether, isop Pills ether, one or more mixed solvents selected from polar solvents such as ethers such as n- butyl ether can be preferably used, also can be used in phosphate buffered saline. Or low polarity or non-polarity such as petroleum ether, n-hexane, n-pentane, n-butane, n-octane, cyclohexane, squalane and other hydrocarbons, carbon tetrachloride, chloroform, dichloromethane, trichloroethylene, benzene, toluene One or two or more mixed solvents selected from solvents can also be suitably used. Furthermore, 1 type, or 2 or more types of supercritical fluids and subcritical fluids, such as water, a carbon dioxide, ethylene, propylene, ethanol, methanol, ammonia, can also be used.

  As extraction methods, extraction is carried out by impregnation under normal pressure or under pressure or reduced pressure at room temperature, in a cooled or heated state, extraction using a distillation method such as steam distillation, squeaker of the genus Pleurotus genus. The squeezing method etc. which obtain an extract are illustrated, and these methods can also be extracted individually or in combination of 2 or more types.

  The crucible extract thus obtained can be used as it is, but as long as the effect is not lost, purification operations such as deodorization, decolorization and concentration are added, and further column chromatography is performed. May be used as a fraction. These extracts, purified products, and fractions thereof can be dried by removing the solvent from them, and further used in a form solubilized in a solvent such as alcohol or in the form of an emulsion. be able to.

  The skin beautifying composition of the present invention can be contained in a skin external preparation such as cosmetics, pharmaceuticals, and quasi drugs. Cosmetics include emulsion, soap, facial cleanser, bath preparation, cream, emulsion, lotion, eau de cologne, shaving cream, shaving lotion, cosmetic oil, sunscreen lotion, funny powder, foundation, perfume, pack, nails Creams, enamels, enamel removers, eyebrows, blushers, eye creams, eye shadows, mascaras, eye liners, lipsticks, lip balms, shampoos, rinses, hair dyes, dispersions, cleaning agents and the like. Examples of the medicinal product or quasi-drug include medicinal products such as ointments, creams, and liquids for external use.

  In addition to the above essential components, the external preparation for skin of the present invention contains ingredients that are blended in external preparations for skin such as cosmetics and quasi-drugs, oils, higher alcohols, fatty acids, ultraviolet absorbers, in addition to the above essential components. Powders, pigments, surfactants, polyhydric alcohols, sugars, polysaccharides, amino acids, peptides, proteins, polymer compounds, physiologically active ingredients, solvents, antioxidants, fragrances, preservatives, and the like can be blended.

  Moreover, the composition for beautiful skin of this invention can be contained in food-drinks. For example, confectionery (gum, candy, caramel, chocolate, cookies, snack confectionery, jelly, gummy, tablet confectionery, etc.), noodles (soba, udon, ramen, etc.), dairy products (milk, ice cream, yogurt, etc.), seasoning (Miso, soy sauce, etc.), soups, beverages (juice, coffee, tea, tea, carbonated drinks, sports drinks, etc.) and other general and health foods (tablets, capsules, etc.), nutritional supplements (nutrient drinks, etc.) ) And the like.

  You may add the skin beautifying composition of this invention to an instant food. For example, a composition for beautifying skin that is spray-dried or freeze-dried together with powdered cellulose can be easily contained in a food or drink by making it into powder, granule, tableting or solution.

  The skin beautifying composition of the present invention is not limited to a skin external preparation, but can be contained in drugs (including pharmaceuticals and quasi drugs) used for oral administration. For example, it can be in the form of products such as soft / hard capsules or tablets, granules, fine granules, powders, liquids and the like.

  The present invention will be described in more detail with reference to examples.

[Preparation Example 1] Freeze-dried cruciferous body The body part of the crucible ( Gymnothorax kidako ), from which bones, skin, internal organs, wings and scales have been removed, is dried by freeze-drying and freeze-dried crucible body 447.06 g was obtained.

[Preparation Example 2] Molybdenum liver freeze-dried product 300.4 g of crucible liver ( Gymnothorax kidako ) was dried by freeze-drying method to obtain 148.3 g of crucible liver freeze-dried product.

[Preparation Example 3] Moray eel body supercritical extract 10.03 g of the crabs body freeze-dried product obtained in Preparation Example 1 was used to obtain 25 MPa carbon dioxide at 40 ° C. and atmospheric pressure at the outlet of the separation tank using a supercritical extraction device. The supercritical carbon dioxide was supplied for 3 hours while adjusting the flow rate of carbon dioxide below to be 3 mL / min. Thereafter, the pressure in the extraction tank was reduced, and the extract and the residue were taken out. The yield of the extract was 1.16 g.

[Preparation Example 4] Critical extract of moray eel liver 15.22 g of the lyophilized crucifer liver obtained in Preparation Example 2 was subjected to 25 MPa carbon dioxide at 40 ° C. under atmospheric pressure at 40 ° C. using a supercritical extraction device. The carbon dioxide in a supercritical state was supplied for 3 hours while adjusting the flow rate of carbon dioxide at 3 mL / min. Thereafter, the pressure in the extraction tank was reduced, and the extract and the residue were taken out. The yield of the extract was 1.24g.

[Preparation Example 5] Crucible hydrophilic solvent extract All parts of the sun-dried crucible ( Gymnothorax kidako ) were pulverized and immersed in a 50 vol% ethanol aqueous solution for 1 week with occasional stirring, and then the supernatant was collected and dried under reduced pressure. The solvent was removed to obtain a crucible hydrophilic solvent extract.

[Preparation Example 6] Moray eel body hot water extract The crabs body freeze-dried product obtained in Preparation Example 1 was pulverized and heated in 10 times the amount of hot water for 4 hours, and then the supernatant was collected and dried under reduced pressure. Then, the solvent was removed, and a crucible body hot water extract was obtained.

  Then, the Example of the cosmetic composition using the moray prepared in the preparation example is shown.

[Examples 1-6, Comparative Example 1] Granule (1) Crucible preparation example shown in Table 1 5.0 (wt%)
(2) Citric acid 2.5
(3) Powdered sugar 50.0
(4) Ascorbic acid 1.0
(5) Fragrance 0.1
(6) Lactose 41.4
Manufacturing method: (1) to (6) are mixed, an appropriate amount of an 80% by volume ethanol aqueous solution is added, and extrusion granulation is performed, followed by drying.

[Examples 7 to 12, Comparative Example 2] Tablet (1) Crucible preparation example shown in Table 1 5.00 (% by weight)
(2) Citric acid 4.00
(3) Powdered sugar 50.00
(4) Lactose 37.49
(5) Saflower Yellow 0.01
(6) Fragrance 0.10
(7) Sucrose fatty acid ester 3.00
Production method: An appropriate amount of an 80% by volume aqueous ethanol solution is added to the mixture of (1) to (5), granulated, and then dried. Next, (6) and (7) are added and tableted.

[Examples 13 to 18, Comparative Example 3] Skin cream
(1) Beeswah 6.00 (wt%)
(2) Cetanol 5.00
(3) Reduced lanolin 8.00
(4) Squalane 37.50
(5) Fatty acid glycerin 4.00
(6) Lipophilic glyceryl monostearate 2.00
(7) Polyoxyethylene (20E.O.) sorbitan
Monolauric acid ester 2.00
(8) Propylene glycol 5.00
(9) Methyl parahydroxybenzoate 0.10
(10) Amount with 100% purified water
(11) Moray eel preparation examples shown in Table 1 0.50
(12) Fragrance 0.20
Production method: The oil phase components (1) to (7) are mixed, dissolved and made uniform, and heated to 75 ° C. On the other hand, the water phase components (8) to (10) are mixed and dissolved and heated to 75 ° C. Subsequently, after adding an oil phase component to the said water phase component and pre-emulsifying, it emulsifies uniformly with a homomixer. Thereafter, the mixture is cooled, and (11) to (12) are added and mixed at 50 ° C.

  A use test was conducted on the examples and comparative examples of the present invention. In the use test, 20 female panelists in their 30s to 60s who exhibit skin aging symptoms such as fine lines, sagging skin, and rough skin are used as one group, and each of the examples and comparative examples is blinded to each group. Ingested. For Examples 1 to 6 and Comparative Example 1, 5g twice a day, for Examples 7 to 12 and Comparative Example 2, 2 tablets twice a day, Examples 13 to 18 And about the comparative example 3, the normal usage-amount was ingested or apply | coated twice a day for two months. Before and after the use test, the skin condition was observed, and a questionnaire survey was conducted on skin texture, elasticity, dryness, skin color, spots, fine lines, and makeup paste. The results are shown in Tables 2 to 4 in terms of the number of panelists who answered that there was an effect.

  As is clear from Tables 2 to 4, in the group using the examples of the present invention, the number of panelists who answered that there was an effect of improving the skin condition was higher than in the comparative examples, and improvements such as dryness, wrinkles, and elasticity were improved. The effect was recognized.

[Example 19] Beverage (1) Crucible hydrophilic solvent extract (Preparation Example 5) 3.00 (wt%)
(2) Fragrance 0.10
(3) Ethanol 0.50
(4) Citric acid 0.70
(5) Glucose 6.00
(6) Purified water 89.70
Production method: Dissolve (1) and (2) in (3), add to (6) together with (4) and (5), mix, dissolve, filter, heat sterilize, and fill into bottles.

[Example 20] Beverage (1) Moray eel hot water extract (Preparation Example 6) 5.0 (wt%)
(2) Fragrance 0.1
(3) Citric acid 0.7
(4) Reduced maltose starch syrup 6.0
(5) Purified water 88.2
Manufacturing method: (1) to (4) are sequentially added to (5), mixed, dissolved, filtered, heat-sterilized, and filled into a bottle.

Example 21 Granule (1) Moray lyophilized product (Preparation Example 1) 5.0 (wt%)
(2) Moray eel liver lyophilizate (Preparation Example 2) 5.0
(3) Citric acid 2.5
(4) Powdered sugar 50.0
(5) Vitamin E 1.0
(6) Fragrance 0.1
(7) Lactose 36.4
Production method: (1) to (7) are mixed, an appropriate amount of 80% by volume ethanol aqueous solution is added, extrusion granulation is performed, and then drying is performed.

[Example 22] Hair nourishing agent
(1) Purified water 48.0 (wt%)
(2) Ethanol 50.0
(3) Moray eel body supercritical extract (Preparation Example 3) 1.0
(4) Moray liver supercritical extract (Preparation Example 4) 1.0
Production method: Components (1) to (4) are mixed and homogenized.

[Example 23] Emulsion
(1) Squalane 5.0 (% by weight)
(2) White petrolatum 2.0
(3) Beeswax 0.5
(4) Sorbitan sesquioleate 0.8
(5) Polyoxyethylene (20E.O.) oleyl ether 1.2
(6) Phytosteryl isostearate 3.0
(7) Methyl paraoxybenzoate 0.1
(8) Propylene glycol 5.0
(9) Purified water Amount of 100
(10) Carboxyvinyl polymer (1 wt% aqueous solution) 20.0
(11) Potassium hydroxide (10% by weight aqueous solution) 1.0
(12) Moray eel hydrophilic solvent extract (Preparation Example 5) 0.5
(13) Ethanol 5.0
(14) Fragrance 0.2
Production method: The oil phase components (1) to (6) are mixed and heated to 75 ° C. to dissolve and homogenize. On the other hand, the water phase components (7) to (9) are mixed and dissolved, heated to 75 ° C., and the oil phase component is added and pre-emulsified. After (10) is added, the mixture is uniformly emulsified with a homomixer, and (11) is added to adjust the pH. After cooling, add and mix (12) to (14) at 40 ° C.

[Example 24] Skin lotion
(1) Ethanol 10.0 (wt%)
(2) Hydroxyethyl cellulose 1.0
(3) Moray eel body hot water extract (Preparation Example 6) 0.5
(4) Methyl paraoxybenzoate 0.1
(5) Glycerin 10.0
(6) 1,3-Butylene glycol 10.0
(7) Purified water Mass production method with a total amount of 100: (1) to (7) are mixed and made uniform.

[Example 25] Emulsion for skin
(1) Stearic acid 0.2 (% by weight)
(2) Cetanol 1.5
(3) Vaseline 3.0
(4) Liquid paraffin 7.0
(5) Polyoxyethylene (10E.O.) monooleate 1.5
(6) Tocopherol acetate 0.5
(7) Glycerin 5.0
(8) Methyl paraoxybenzoate 0.1
(9) Triethanolamine 1.0
(10) Purified water 79.2
(11) Moray eel body supercritical extract (Preparation Example 3) 0.5
(12) Moray liver supercritical extract (Preparation Example 4) 0.5
Production method: The oil phase components (1) to (6) are mixed, heated and uniformly dissolved, and kept at 70 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and heated to be uniform, and set to 70 ° C. The oil phase component is gradually added to the aqueous phase component with stirring and emulsified. After cooling, the components (11) and (12) are added and mixed at 40 ° C.

[Example 26] Gel for skin
(1) Purified water 78.5 (wt%)
(2) Carboxyvinyl polymer 0.5
(3) Dipropylene glycol 20.0
(4) Methyl paraoxybenzoate 0.1
(5) Potassium hydroxide 0.1
(6) Moray eel body hot water extract (Preparation Example 6) 0.8
Manufacturing method: (2) is uniformly dissolved in (1), (4) is dissolved and added to (3), and then (5) is added to increase the viscosity. Added.

[Example 27] Skin cream
(1) Beeswaw 6.0 (wt%)
(2) Cetanol 5.0
(3) Reduced lanolin 8.0
(4) Squalane 29.5
(5) Lipophilic glycerin monostearate 4.0
(6) Polyoxyethylene (20E.O.)
Sorbitan monolaurate 5.0
(7) Propylene glycol 8.0
(8) Glycerin 5.0
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 28.4
(11) Moray eel hydrophilic solvent extract (Preparation Example 5) 1.0
Production method: The oil phase components (1) to (6) are mixed, dissolved, and heated to 75 ° C. On the other hand, the aqueous phase components (7) to (10) are mixed and dissolved and heated to 75 ° C. Next, the oil phase component is added to the water phase component and pre-emulsified, and then uniformly emulsified with a homomixer. After cooling, the component (11) is added and mixed at 40 ° C.

Example 28 Oil-in-water emulsion ointment
(1) White petrolatum 25.0 (wt%)
(2) Stearyl alcohol 25.0
(3) Glycerin 15.0
(4) Sodium lauryl sulfate 1.0
(5) Methyl paraoxybenzoate 0.1
(6) Purified water 32.9
(7) Moray eel hot water extract (Preparation Example 6) 1.0
Production method: The oil phase components (1) to (4) are mixed, dissolved and made uniform, and heated to 75 ° C. On the other hand, (5) is dissolved in (6) and heated to 75 ° C., the oil phase component is added thereto to emulsify, and after cooling, (7) is added and mixed at 40 ° C.

[Example 29] Lotion
(1) Ethanol 10.0 (wt%)
(2) 1,3-butylene glycol 20.0
(3) Moray eel hydrophilic solvent extract (Preparation Example 5) 0.5
(4) Fragrance 0.1
(5) Purified water 69.4
Production method: (1) to (4) are sequentially added to (5) and mixed and dissolved uniformly.

Example 30 Water-in-oil emulsified emollient cream
(1) Liquid paraffin 30.0 (wt%)
(2) Microcrystalline wax 2.0
(3) Vaseline 5.0
(4) Diglycerin oleate 5.0
(5) Sodium L-glutamate 1.6
(6) L-serine 0.4
(7) Propylene glycol 3.0
(8) 1,3-butylene glycol 5.0
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 47.3
(11) Fragrance 0.1
(12) Moray liver supercritical extract (Preparation Example 4) 0.5
Production method: (5) and (6) are dissolved in a part of (10) to 50 ° C., and gradually added to (4) heated to 50 ° C. with stirring. This was mixed in advance and uniformly dispersed in (1) to (3) dissolved at 70 ° C., and (7) to (9) were dissolved in the remainder of (10) and heated to 70 ° C. Is added with stirring and emulsified with a homomixer. After cooling, add and mix components (11) and (12) at 40 ° C.

[Example 31] Make-up base cream
(1) Stearic acid 12.0 (wt%)
(2) Cetanol 2.0
(3) Glycerin tri-2-ethylhexanoate 2.5
(4) Self-emulsifying glycerin monostearate 2.0
(5) Propylene glycol 11.0
(6) Potassium hydroxide 0.3
(7) Purified water 68.1
(8) Titanium oxide 1.0
(9) Bengala 0.1
(10) Yellow iron oxide 0.4
(11) Fragrance 0.1
(12) Moray eel hydrophilic solvent extract (Preparation Example 5) 0.5
Production method: The oil phase components (1) to (4) are mixed and heated to 75 ° C. to be uniform. On the other hand, the aqueous phase components (5) to (7) are mixed, heated and dissolved at 75 ° C. to make it uniform, and the pigments (8) to (10) are added to this and dispersed uniformly with a homomixer. Let The oil phase component is added to the water phase component, emulsified with a homomixer, cooled, and the components (11) and (12) are added and mixed at 40 ° C.

[Example 32] Emulsion foundation
(1) Stearic acid 2.0 (wt%)
(2) Squalane 5.0
(3) Octyldodecyl myristate 5.0
(4) Cetanol 1.0
(5) Decaglycerin monoisopalmitate 9.0
(6) Macadamia nut fatty acid phytosteryl 0.5
(7) 1,3-butylene glycol 8.0
(8) Potassium hydroxide 0.1
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 50.6
(11) Titanium oxide 9.0
(12) Talc 7.4
(13) Bengala 0.5
(14) Yellow iron oxide 1.1
(15) Black iron oxide 0.1
(16) Fragrance 0.1
(17) Moray eel body hot water extract (Preparation Example 6) 0.5
Production method: The oil phase components (1) to (6) are mixed and heated to 75 ° C. to be uniform. On the other hand, the water phase components (7) to (10) are mixed, heated and dissolved at 75 ° C. to make it uniform, and the pigments (11) to (15) are added thereto and uniformly emulsified with a homomixer. After cooling, add components (16) and (17) at 40 ° C and mix.

[Example 33] Hand cream
(1) Cetanol 4.0 (wt%)
(2) Vaseline 2.0
(3) Liquid paraffin 10.0
(4) Glycerin monostearate 1.5
(5) Polyoxyethylene (20E.O.)
Glycerol isostearate 2.5
(6) Tocopherol acetate 0.5
(7) Soybean phospholipid 0.5
(8) Glycerin 20.0
(9) Methyl paraoxybenzoate 0.1
(10) Purified water 58.4
(11) Moray eel hydrophilic solvent extract (Preparation Example 5) 0.5
Production method: The oil phase components (1) to (7) are mixed, dissolved, and heated to 75 ° C. On the other hand, the water phase components (8) to (10) are mixed and dissolved and heated to 75 ° C. Next, the oil phase component is added to the water phase component and pre-emulsified, and then uniformly emulsified with a homomixer and cooled, and the component (11) is added and mixed at 40 ° C.

Claims (3)

A composition for beautiful skin containing a moray and / or an extract thereof. An external preparation containing a moray and / or an extract thereof as a beautifying skin composition. A food or drink containing a moray and / or an extract thereof as a beautifying skin composition.