JP2006028115A - Antimicrobial agent - Google Patents
Antimicrobial agent Download PDFInfo
- Publication number
- JP2006028115A JP2006028115A JP2004211140A JP2004211140A JP2006028115A JP 2006028115 A JP2006028115 A JP 2006028115A JP 2004211140 A JP2004211140 A JP 2004211140A JP 2004211140 A JP2004211140 A JP 2004211140A JP 2006028115 A JP2006028115 A JP 2006028115A
- Authority
- JP
- Japan
- Prior art keywords
- oligosaccharide
- acid
- stearyl
- mass
- purified water
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 239000000126 substance Substances 0.000 claims abstract description 13
- 125000001183 hydrocarbyl group Chemical group 0.000 claims abstract 2
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- 150000002482 oligosaccharides Chemical class 0.000 claims description 50
- 239000003242 anti bacterial agent Substances 0.000 claims description 17
- 125000004432 carbon atom Chemical group C* 0.000 claims description 4
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- UUJLHYCIMQOUKC-UHFFFAOYSA-N trimethyl-[oxo(trimethylsilylperoxy)silyl]peroxysilane Chemical compound C[Si](C)(C)OO[Si](=O)OO[Si](C)(C)C UUJLHYCIMQOUKC-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Food Preservation Except Freezing, Refrigeration, And Drying (AREA)
- Saccharide Compounds (AREA)
- Cosmetics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Detergent Compositions (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
本発明は抗菌剤に関する。さらに詳しくは皮膚外用組成物、洗浄料、食品、日用品等に好ましく使用できる広範な微生物に対して優れた抗菌活性を有し、人体に安全な抗菌剤に関する。 The present invention relates to an antibacterial agent. More specifically, the present invention relates to an antibacterial agent that has excellent antibacterial activity against a wide range of microorganisms that can be preferably used in a composition for external use on skin, a cleaning material, food, daily necessities, etc., and is safe for the human body.
微生物の増殖を抑制するために、食品・医薬品・化粧品類等の抗菌・防腐剤としては、ソルビン酸、デヒドロ酢酸及びその塩、パラオキシ安息香酸誘導体などがよく使用されているが、安全性の点で問題があり、添加量や対象食品が制限（例えば、ソルビン酸及びその塩の食品への配合上限は０．２％であり、デヒドロ酢酸及びその塩は、チーズ、バター及びマーガリンにのみ使用可能、又、パラオキシ安息香酸メチルナトリウムの化粧品類への配合上限は１．０％）されていた。 In order to suppress the growth of microorganisms, sorbic acid, dehydroacetic acid and its salts, paraoxybenzoic acid derivatives, etc. are often used as antibacterial and antiseptic agents for foods, pharmaceuticals, cosmetics, etc. There is a problem, and the amount of addition and target food are limited (for example, the upper limit of incorporation of sorbic acid and its salt into food is 0.2%, dehydroacetic acid and its salt can be used only for cheese, butter and margarine In addition, the upper limit of incorporation of methyl sodium paraoxybenzoate into cosmetics was 1.0%).
又、微生物の増殖を抑制するために、生体では皮膚や粘膜で物理的若しくは殺菌性物質や粘液の分布といった化学的な方法によって、微生物の侵入を抑え、更に、生体内に侵入した微生物に対しては、免疫グロブリンによる付着阻止、食細胞による食作用、リゾチームによる溶菌作用等、先天的で非特異的な感染抵抗や特定の病原菌に対する免疫応答などによって抵抗が行われている。 In order to suppress the growth of microorganisms, in the living body, the invasion of microorganisms is suppressed by chemical methods such as physical or bactericidal substances and mucus distribution in the skin and mucous membranes. For example, resistance is achieved by innate and nonspecific infection resistance, immune response to specific pathogens, such as adhesion prevention by immunoglobulin, phagocytosis by phagocytic cells, and lysis by lysozyme.
しかしながら、もし、微生物の感染力が生体における抵抗力を上回ってしまえば、生体内では、例えば、黄色ブドウ球菌による膿皮症などの感染性皮膚炎、食中毒、敗血症、枯草菌による結膜炎、虹彩炎、大腸菌による尿路感染症、下痢症など、又、アクチノバシルスなどによる歯周病、う触原菌による虫歯、更にニキビ菌（プロピオニバクテリウムアクネス）、フケ菌（ピティロスポルムオバーレ）などによるニキビ、フケ又はフケに伴うカユミ等、様々な感染症を起こす危険性がある。 However, if the infectivity of microorganisms exceeds the resistance in the body, in vivo, for example, infectious dermatitis such as pyoderma caused by Staphylococcus aureus, food poisoning, sepsis, conjunctivitis due to Bacillus subtilis, iritis Urinary tract infections due to Escherichia coli, diarrhea, periodontal disease due to Actinobacillus, caries due to protozoa, acne (propionibacteria acnes), dandruff (Pityrosporum obare) There is a risk of causing various infectious diseases such as acne, dandruff or scabs accompanying dandruff.
従って、生体内外における感染症の予防や治療に対して、これまで様々な薬物が使用されて来たが、その大半を占める抗生物質や抗菌・防腐剤は、確かにその効果は強いが、安全性の面で問題があり、これらの使用には厳重な注意が必要で、その効力、安全性などの面において、更に有用な物質が求められていた。
そこで、本発明者らは、細菌、酵母、カビなどの微生物による感染症、疾患に対して抗菌、防腐効果、すなわち、殺菌若しくは経時により増殖を防止する効果があり、且つ、各種分野に利用しても安全であるものを探求すべく鋭意研究を重ねてきた。
Therefore, various drugs have been used for the prevention and treatment of infectious diseases in and outside the body. Antibiotics, antibacterials and antiseptics, which account for the majority of these drugs, have strong effects, but are safe. There is a problem in terms of sexuality, and strict attention is required for their use, and more useful substances have been demanded in terms of efficacy and safety.
Therefore, the present inventors have antibacterial and antiseptic effects against infectious diseases and diseases caused by microorganisms such as bacteria, yeasts, and molds, that is, have the effect of sterilizing or preventing proliferation over time, and are used in various fields. However, I have been eagerly researching what is safe.
本発明は、広範な微生物に対して優れた抗菌活性を有し、人体に安全な抗菌剤を提供することを技術的課題とする。 An object of the present invention is to provide an antibacterial agent that has excellent antibacterial activity against a wide range of microorganisms and is safe for the human body.
本発明者らは、上記の課題に鑑み、下記化学式（１）で表わされるカチオン化オリゴ糖が各種の微生物に対して強い抗菌・防腐効果を有し、人又は動物に対して安全であることを確認し、新規な抗菌剤として各種分野に応用することが非常に有効であることを発見し、本発明を完成するに至った。
即ち、本発明は下記化学式（１）で表わされるカチオン化オリゴ糖からなる抗菌剤である。
以下、本発明の構成について詳述する。 Hereinafter, the configuration of the present invention will be described in detail.
本発明に用いる下記化学式（１）のカチオン化オリゴ糖は、塩化Ｏ−[２−ヒドロキシ−３−アルキルジメチルアンモニオ]プロピルオリゴ糖、又は、アルキルジヒドロキシプロピルジモニウムオリゴ糖と称され、公知物質であるが抗菌剤としては新規な用途である。
本発明に用いるカチオン化オリゴ糖はＡｒｃｈＰｅｒｓｏｎａｌＣａｒｅ Ｐｒｏｄｕｃｔｓ社等から市販されており（商品名：ＯｌｉｇｏｑｕａｔＭ：ステアリルジヒドロキシプロピルジモニウムオリゴ糖とプロピレングリコールの混合物）、容易に入手することができる。 The cationized oligosaccharide used in the present invention is commercially available from ArchPersonalCare Products, Inc. (trade name: Oligoquat M: a mixture of stearyl dihydroxypropyldimonium oligosaccharide and propylene glycol) and can be easily obtained.
本発明に用いるカチオン化オリゴ糖は、１，３−ブチレングリコール、プロピレングリコール等のジオール類や水の混合物として配合してもよい。 The cationized oligosaccharide used in the present invention may be blended as a mixture of diols such as 1,3-butylene glycol and propylene glycol, and water.
本発明の抗菌剤は任意の皮膚外用組成物へ配合することができる。また、本発明の抗菌剤は医療器具類や患部の消毒洗浄を目的とする医療用洗浄料；食器等を殺菌洗浄する家庭用洗浄料；食品工業用洗浄料；食品包装フィルム、繊維、合成樹脂、木材、日用品等を抗菌加工するための抗菌剤；抗菌性塗料；口腔用組成物（ガム、キャンディ等）やかまぼこ、ちくわ等の水産ねり製品、ソーセージ、ハム等の畜産製品、菓子類、めん類、ソース、醤油等の調味料、惣菜、飲料等の食品のための抗菌剤等としても配合することができる。 The antibacterial agent of this invention can be mix | blended with arbitrary skin external compositions. Further, the antibacterial agent of the present invention is a medical cleaning agent for disinfecting and cleaning medical instruments and affected parts; a household cleaning agent for sterilizing and cleaning dishes; a food industry cleaning agent; a food packaging film, a fiber, and a synthetic resin Antibacterial agent for antibacterial processing of wood, daily necessities, etc .; antibacterial paint; marine products such as oral composition (gum, candy, etc.), kamaboko, chikuwa, livestock products such as sausage, ham, confectionery, noodles Also, it can be blended as a seasoning such as sauce and soy sauce, an antibacterial agent for food such as side dishes and beverages, and the like.
本発明の抗菌剤の使用方法は特に限定されず、様々な対象に適用することができる。例えば、対象物に添加する方法、スプレーする方法、塗布する方法、浸漬させる方法、含浸させる方法、成形加工時等に練りこむ方法等、通常採用される方法をそのまま用いることができる。 The usage method of the antibacterial agent of this invention is not specifically limited, It can apply to various object. For example, methods usually employed such as a method of adding to an object, a spraying method, a coating method, a dipping method, an impregnation method, and a kneading method at the time of molding can be used as they are.
本発明の抗菌剤は、そのままでも利用できるが、抗菌剤として配合する場合の配合量は、製品形態、期待される作用の程度により異なり特に限定されないが、通常、１００ｐｐｍ以上、好ましくは、１０００ｐｐｍ以上が良い。 The antibacterial agent of the present invention can be used as it is, but the blending amount when blended as an antibacterial agent varies depending on the product form and the degree of expected action and is not particularly limited, but is usually 100 ppm or more, preferably 1000 ppm or more. Is good.
又、本発明のカチオン化オリゴ糖を各種組成物に配合する場合は、本発明の効果を損なわない範囲内で、食品、化粧品、医薬品、医薬部外品等に一般的に用いられる各種成分、例えば、砂糖、練乳、小麦粉、ショートニング、食塩、ブドウ糖、鶏卵、バター、マーガリン、水飴、カルシウム、鉄分、調味料、香辛料や油分（動植物油、鉱物油、エステル油、ワックス油、シリコーン油、高級アルコール、リン脂質類、脂肪酸類等）、界面活性剤（アニオン性、カチオン性、両性又は非イオン性界面活性剤）、ビタミン類（ビタミンＡ群、ビタミンＢ群、葉酸類、ニコチン酸類、パントテン酸類、ビオチン類、ビタミンＣ群、ビタミンＤ群、ビタミンＥ群、その他フェルラ酸、γ−オリザノール等）、紫外線吸収剤（ｐ−アミノ安息香酸、アントラニル、サルチル酸、クマリン、ベンゾトリアゾール、テトラゾール、イミダゾリン、ピリミジン、ジオキサン、フラン、ピロン、カンファー、核酸、アラントイン及びそれらの誘導体、アミノ酸系化合物、シコニン、バイカリン、バイカレイン、ベルベリン等）、抗酸化剤（ステアリン酸エステル、ノルジヒドログアセレテン酸、ジブチルヒドロキシトルエン、ブチルヒドロキシアニソール、パラヒドロキシアニソール、没食子酸プロピル、セサモール、セサモリン、ゴシポール等）、増粘剤（ヒドキシエチルセルロース、エチルセルロース、カルボキシエチルセルロース、メチルセルロース、カルボキシメチルセルロース、カルボキシメチルセルロースナトリウム、ヒドキシプロピルセルロース、ニトロセルロース、ポリビニルアルコール、ポリビニルメチルエーテル、ポリビニルピロリドン、ポリビニルメタアクリレート、ポリアクリル酸塩、カルボキシビニルポリマー、アラビアゴム、トラガントゴム、寒天、カゼイン、デキストリン、ゼラチン、ペクチン、デンプン、アルギン酸及びその塩等）、保湿剤（プロピレングリコール、１，３−ブチレングリコール、ポリエチレングリコール、グリセリン、１，２−ペンタンジオール、ヘキシレングリコール、オクチレングリコール、コンドロイチン硫酸及びその塩、ヒアルロン酸及びその塩、乳酸ナトリウム等）又、その他、低級アルコール、多価アルコール、水溶性高分子、ｐＨ調整剤、防腐・防黴剤、着色料、香料、清涼剤、安定化剤、動・植物抽出物、動・植物性蛋白質及びその分解物、動・植物性多糖類及びその分解物、動・植物性糖蛋白質及びその分解物、微生物培養代謝成分、血流促進剤、消炎剤、抗炎症剤、抗アレルギー剤、細胞賦活剤、アミノ酸及びその塩、角質溶解剤、収斂剤、創傷治療剤、増泡剤、口腔用剤、消臭・脱臭剤、乳化剤等と共に配合し、併用して用いることもできる。 In addition, when the cationized oligosaccharide of the present invention is blended in various compositions, various components generally used in foods, cosmetics, pharmaceuticals, quasi-drugs, etc. within the range not impairing the effects of the present invention, For example, sugar, condensed milk, flour, shortening, salt, glucose, chicken eggs, butter, margarine, starch syrup, calcium, iron, seasonings, spices and oils (animal and vegetable oils, mineral oils, ester oils, wax oils, silicone oils, higher alcohols) Phospholipids, fatty acids, etc.), surfactants (anionic, cationic, amphoteric or nonionic surfactants), vitamins (vitamin A group, vitamin B group, folic acid, nicotinic acid, pantothenic acid, Biotins, vitamin C group, vitamin D group, vitamin E group, other ferulic acid, γ-oryzanol, etc.), UV absorber (p-aminobenzoic acid, anne) Ranyl, salicylic acid, coumarin, benzotriazole, tetrazole, imidazoline, pyrimidine, dioxane, furan, pyrone, camphor, nucleic acid, allantoin and their derivatives, amino acid compounds, shikonin, baicalin, baicalein, berberine, etc.), antioxidant ( Stearic acid ester, nordihydrogua cetelenic acid, dibutylhydroxytoluene, butylhydroxyanisole, parahydroxyanisole, propyl gallate, sesamol, sesamorin, gossypol, etc.), thickener (hydroxyethylcellulose, ethylcellulose, carboxyethylcellulose, methylcellulose, Carboxymethylcellulose, sodium carboxymethylcellulose, hydroxypropylcellulose, nitrocellulose, polyvinyl alcohol , Polyvinyl methyl ether, polyvinylpyrrolidone, polyvinyl methacrylate, polyacrylate, carboxyvinyl polymer, gum arabic, tragacanth gum, agar, casein, dextrin, gelatin, pectin, starch, alginic acid and its salts), moisturizer (propylene) Glycol, 1,3-butylene glycol, polyethylene glycol, glycerin, 1,2-pentanediol, hexylene glycol, octylene glycol, chondroitin sulfate and its salt, hyaluronic acid and its salt, sodium lactate, etc.) Alcohol, polyhydric alcohol, water-soluble polymer, pH adjuster, antiseptic / antifungal agent, coloring agent, fragrance, refreshing agent, stabilizer, animal / plant extract, animal / plant protein and its degradation product, animal・ Plant polysaccharides and their equivalents Products, animal / plant glycoproteins and degradation products thereof, microbial culture metabolic components, blood flow promoters, anti-inflammatory agents, anti-inflammatory agents, anti-allergic agents, cell activators, amino acids and salts thereof, keratolytic agents, astringents, It can also be used in combination with a wound treatment agent, foam increasing agent, oral preparation, deodorant / deodorant, emulsifier and the like.
又、本発明のカチオン化オリゴ糖を皮膚外用組成物に配合した場合の剤型については、任意であり、常法により配合し、例えば、化粧水、クリーム、軟膏、乳液、ファンデーション、オイル、パック、石鹸（薬用石鹸も含む）、ボディソープ、口紅、爪化粧品、眉目化粧品、香水、洗顔料、口腔用類（歯磨き、マウスウオッシュ等）、防臭剤（腋臭、足臭等）、浴用剤、シャンプー、リンス、ヘアトニック、ヘアスプレー、染毛料等の剤型とすることができる。 In addition, the dosage form when the cationized oligosaccharide of the present invention is blended in the composition for external use on the skin is arbitrary, and blended by a conventional method, for example, lotion, cream, ointment, emulsion, foundation, oil, pack , Soap (including medicated soap), body soap, lipstick, nail cosmetics, eyebrow cosmetics, perfume, face wash, oral products (toothpaste, mouthwash, etc.), deodorants (smelly odor, foot odor, etc.), bath preparation, shampoo , Rinse, hair tonic, hair spray, hair dye and the like.
又、本発明のカチオン化オリゴ糖をその他の組成物に配合した場合の剤型についても、任意であり、常法により配合し、例えば、経口薬剤、繊維製品（シーツ類、衣類等）、更に衛生綿類、ウエットティシュや拭き取り用ペーパー類、除菌用クロス等の不織布に、又、口腔用組成物（ガム、キャンデー等）やかまぼこ、ちくわ等の水産ねり製品、ソーセージ、ハム等の畜産製品、洋菓子類、和菓子類、中華めん、うどん、そば等のめん類、ソース、醤油、たれ等の調味料、惣菜、ジュース、スープ等、一般的な飲食類の剤型とすることができる。 In addition, the dosage form when the cationized oligosaccharide of the present invention is blended with other compositions is also optional, and blended by a conventional method, for example, oral drugs, textile products (sheets, clothing, etc.), Sanitary cotton, wet tissue, wiping paper, non-woven cloth such as sterilization cloth, oral products (gum, candy, etc.), fishery products such as kamaboko and chikuwa, and livestock products such as sausage and ham Western food confectionery, Japanese confectionery, Chinese noodles, udon, noodles such as buckwheat, seasonings such as sauces, soy sauce, sauces, side dishes, juices, soups, etc.
更に、本発明のカチオン化オリゴ糖を配合した各種組成物の形態は、任意であり、溶液状、クリーム状、ペースト状、ゲル状、ジェル状、泡状、固形状又は粉末状として用いることができる。 Furthermore, the form of various compositions containing the cationized oligosaccharide of the present invention is arbitrary, and may be used as a solution, cream, paste, gel, gel, foam, solid, or powder. it can.
本発明のカチオン化オリゴ糖は、広範な微生物に対して優れた抗菌活性を有し、人体に安全な抗菌剤が提供できる。 The cationized oligosaccharide of the present invention has an excellent antibacterial activity against a wide range of microorganisms, and can provide an antibacterial agent that is safe for the human body.
次に実施例をあげて本発明をさらに具体的に説明する。本発明はこれによって限定されるものではない。配合量は質量％である。 Next, the present invention will be described more specifically with reference to examples. The present invention is not limited thereby. A compounding quantity is the mass%.
試験例１：抗菌効果
各種の菌に対する最小発育阻止濃度（ＭＩＣ）を求めた。 寒天平板法により、細菌については、カチオン化オリゴ糖としてステアリルジヒドロキシプロピルジモニウムオリゴ糖を用い、各濃度配合したソイビーンカゼインダイジェスト寒天培地（栄研製）に、下記各細菌を接種して３０℃で２４時間培養し、コロニーを形成しない各試験化合物の濃度（最小発育阻止濃度：ＭＩＣ）を求めた。また、真菌については各試験化合物を各濃度配合したポテトデキストロース寒天培地に、下記各真菌を接種して２５℃で４８時間培養し、コロニーを形成しない各試験化合物の濃度（最小発育阻止濃度：ＭＩＣ）を求めた。判定結果は以下の評価基準により表１に示した。
（試験菌）
Ｐｓ：緑膿菌 標準株（菌株名：Pseudomonas aeruginosa ATCC15442）
Ｅ：大腸菌 標準株（菌株名：Escherichia coli ATCC8739）
Ｓ：黄色ブドウ球菌 標準株（菌株名：Staphylococcus aureus ATCC6538）
Ｃａｎ：キャンジダ菌（酵母）標準株（菌株名：Candida albicans ATCC10231）
Ａｓｐ：黒カビ 標準株（菌株名：Aspergillus niger ATCC16404）
Test Example 1: Antibacterial effect The minimum inhibitory concentration (MIC) for various bacteria was determined. According to the agar plate method, for bacteria, stearyl dihydroxypropyl dimonium oligosaccharide was used as a cationized oligosaccharide, and each of the following bacteria was inoculated into a soybean casein digest agar medium (produced by Eiken) at 24C at 24C. After culturing for a while, the concentration of each test compound that did not form colonies (minimum growth inhibitory concentration: MIC) was determined. As for fungi, potato dextrose agar medium containing each test compound at various concentrations was inoculated with the following fungi, cultured at 25 ° C. for 48 hours, and the concentration of each test compound that did not form colonies (minimum growth inhibitory concentration: MIC). ) The determination results are shown in Table 1 according to the following evaluation criteria.
(Test bacteria)
Ps: Pseudomonas aeruginosa standard strain (strain name: Pseudomonas aeruginosa ATCC15442)
E: E. coli standard strain (Strain name: Escherichia coli ATCC8739)
S: Staphylococcus aureus standard strain (strain name: Staphylococcus aureus ATCC6538)
Can: Candida albicans standard strain (strain name: Candida albicans ATCC10231)
Asp: black mold standard strain (strain name: Aspergillus niger ATCC16404)
（評価基準）
Ａ：最小発育阻止濃度が１０００ｐｐｍ未満
Ｂ：最小発育阻止濃度が、１０００ｐｐｍ以上、５０００ｐｐｍ未満
Ｃ：最小発育阻止濃度が、５０００ｐｐｍ以上、１００００ｐｐｍ未満
Ｄ：最小発育阻止濃度が、１００００ｐｐｍ以上、３００００ｐｐｍ未満
Ｅ：最小発育阻止濃度が、３００００ｐｐｍ以上
(Evaluation criteria)
A: Minimum growth inhibition concentration is less than 1000 ppm B: Minimum growth inhibition concentration is 1000 ppm or more and less than 5000 ppm C: Minimum growth inhibition concentration is 5000 ppm or more and less than 10,000 ppm D: Minimum growth inhibition concentration is 10000 ppm or more and less than 30000 ppm E: Minimum growth inhibitory concentration is 30000ppm or more
試験例２：安全性試験
本試験に用いたステアリルジヒドロキシプロピルジモニウムオリゴ糖はＡｒｃｈＰｅｒｓｏｎａｌＣａｒｅ Ｐｒｏｄｕｃｔｓ社にて安全性試験を行っている。それによるとＲＩＰＴ試験、及び皮膚刺激試験、眼刺激を行った結果、いずれも刺激性は極めて弱いと判断された。
Test Example 2: Safety Test Stearyl dihydroxypropyl dimonium oligosaccharide used in this test is being tested for safety at ArchPersonalCare Products. According to this, as a result of RIPT test, skin irritation test, and eye irritation, all of the irritation was judged to be extremely weak.
以上のように、本発明に用いるステアリルジヒドロキシプロピルジモニウムオリゴ糖の安全性は良好であった。 As described above, the safety of stearyl dihydroxypropyl dimonium oligosaccharide used in the present invention was good.
以下に、本発明の利用方法を更に詳述するが、本発明は以下の実施例に限定されることはなく、各種の医薬品、医薬部外品、化粧品分野の皮膚外用組成物、洗浄料、食品、日用品等に配合して用いることが出来る。尚、各実施例は各製品の製造における常法により製造したもので良く、配合量のみを示した。 Hereinafter, the method of using the present invention will be described in more detail, but the present invention is not limited to the following examples, and various pharmaceuticals, quasi drugs, compositions for external use in the cosmetics field, cleaning agents, It can be used in foods and daily necessities. In addition, each Example may be what was manufactured by the conventional method in manufacture of each product, and showed only the compounding quantity.
実施例１ 化粧水 質量％
エタノール ５．０
１，３−ブチレングリコール ６．０
グリセリン ４．０
オレイルアルコール ０．１
ＰＯＥ（２０）ソルビタンモノラウリン酸エステル ０．５
ＰＯＥ（１５）ラウリルエーテル ０．５
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．３
香料 適量
精製水 残余
Example 1 lotion mass%
Ethanol 5.0
1,3-butylene glycol 6.0
Glycerin 4.0
Oleyl alcohol 0.1
POE (20) sorbitan monolaurate 0.5
POE (15) lauryl ether 0.5
Stearyl dihydroxypropyl dimonium oligosaccharide 0.3
Perfume Appropriate amount of purified water
実施例２ 化粧水 質量％
ソルビット ４．０
１，３−ブチレングリコール ６．０
グリセリン ２．０
ＰＯＥ（２０）オレイルアルコールエーテル ０．５
メチルセルロース ０．２
クインスシード ０．１
２，２−ジエチル−１，３−プロパンジオール ０．１
エチルヘキサンジオール ０．３
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．２
香料 適量
精製水
Example 2 lotion
Sorbit 4.0
1,3-butylene glycol 6.0
Glycerin 2.0
POE (20) oleyl alcohol ether 0.5
Methylcellulose 0.2
Quince Seed 0.1
2,2-diethyl-1,3-propanediol 0.1
Ethylhexanediol 0.3
Stearyl dihydroxypropyl dimonium oligosaccharide 0.2
Perfume appropriate amount purified water
実施例３ 化粧水 質量％
（アルコール相）
エタノール ５．０
オレイルアルコール ０．２
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．３
ＰＯＥ（２０）ソルビタンモノラウリン酸エステル ０．５
ＰＯＥ（１５）ラウリルエーテル ０．５
４，５−ジモルホリノ−３−ヒドロキシピリダジン ０．１
フェノキシエタノール ０．２
香料 適量
（水相）
１，３−ブチレングリコール ６．０
グリセリン ５．０
精製水 残余
Example 3 lotion
(Alcohol phase)
Ethanol 5.0
Oleyl alcohol 0.2
Stearyl dihydroxypropyl dimonium oligosaccharide 0.3
POE (20) sorbitan monolaurate 0.5
POE (15) lauryl ether 0.5
4,5-Dimorpholino-3-hydroxypyridazine 0.1
Phenoxyethanol 0.2
Perfume appropriate amount (water phase)
1,3-butylene glycol 6.0
Glycerin 5.0
Purified water residue
実施例４ 化粧水 質量％
（アルコール相）
エタノール ５．０
ＰＯＥ（２０）オレイルエーテル ０．５
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．３
香料 適量
（水相）
ジプロピレングリコール ６．０
ソルビット ４．０
ＰＥＧ１５００ ５．０
メチルセルロース ０．２
クインスシード ０．１
精製水 残余
Example 4 lotion
(Alcohol phase)
Ethanol 5.0
POE (20) oleyl ether 0.5
Stearyl dihydroxypropyl dimonium oligosaccharide 0.3
Perfume appropriate amount (water phase)
Dipropylene glycol 6.0
Sorbit 4.0
PEG 1500 5.0
Methylcellulose 0.2
Quince Seed 0.1
Purified water residue
実施例５ 乳液 質量％
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 １．０
グリセリン ３．０
セタノール １．５
ステアリルアルコール １．８
ジメチルポリシロキサン（２０ｃｓ） １．５
スクワラン ２．０
ワセリン ２．０
イソプロピルミリステート ２．５
グリセリルモノステアレート １．８
ポリオキシエチレン（ＰＯＥ＝５）グリセリルモノステアレート １．８
ポリオキシエチレン（ＰＯＥ＝２０）セチルエーテル １．５
カルボキシビニルポリマー ０．２５
水酸化カリウム ０．０５
Ｌ−アルギニン ０．２
ジプロピレングリコール ５．０
１，３−ブチレングリコール ３．０
エデト酸三ナトリウム ０．２
フェノキシエタノール ０．１
精製水 残量
Example 5 Latex mass%
Stearyl dihydroxypropyl dimonium oligosaccharide 1.0
Glycerin 3.0
Cetanol 1.5
Stearyl alcohol 1.8
Dimethylpolysiloxane (20cs) 1.5
Squalane 2.0
Vaseline 2.0
Isopropyl myristate 2.5
Glyceryl monostearate 1.8
Polyoxyethylene (POE = 5) glyceryl monostearate 1.8
Polyoxyethylene (POE = 20) cetyl ether 1.5
Carboxyvinyl polymer 0.25
Potassium hydroxide 0.05
L-Arginine 0.2
Dipropylene glycol 5.0
1,3-butylene glycol 3.0
Edetate trisodium 0.2
Phenoxyethanol 0.1
Purified water remaining
実施例６ 乳液 質量％
ステアリン酸 ２．５
セチルアルコール １．５
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 １．５
３−ヘキシン−２，５−ジオール ０．２
ワセリン ５．０
流動パラフィン １０．０
ＰＯＥ（１０）モノオレイン酸エステル ２．０
ＰＥＧ１５００ ３．０
トリエタノールアミン １．０
３−フェノキシ−１，２−プロパンジオール ２．０
３−ベンジルオキシ−１，２−プロパンジオール １．０
亜硫酸水素ナトリウム ０．０１
カルボキシビニルポリマー ０．０５
香料 適量
精製水 残余
Example 6 Latex Mass%
Stearic acid 2.5
Cetyl alcohol 1.5
Stearyl dihydroxypropyl dimonium oligosaccharide 1.5
3-Hexin-2,5-diol 0.2
Vaseline 5.0
Liquid paraffin 10.0
POE (10) monooleate 2.0
PEG 1500 3.0
Triethanolamine 1.0
3-phenoxy-1,2-propanediol 2.0
3-Benzyloxy-1,2-propanediol 1.0
Sodium bisulfite 0.01
Carboxyvinyl polymer 0.05
Perfume Appropriate amount of purified water
実施例７ 乳液 質量％
流動パラフィン ７．０
ワセリン ３．０
デカメチルシクロペンタシロキサン ２．０
ベヘニルアルコール １．０
グリセリン ５．０
ジプロピレングリコール ７．０
ポリエチレングリコール１５００ ２．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 １．５
ホホバ油 １．０
イソステアリン酸 ０．５
ステアリン酸 ０．５
ベヘニン酸 ０．５
テトラ２−エチルヘキサン酸ペンタエリスリット ３．０
２−エチルヘキサン酸セチル ３．０
モノステアリン酸グリセリン １．０
モノステアリン酸ポリオキシエチレングリセリン １．０
水酸化カリウム ０．１
ヘキサメタリン酸ナトリウム ０．０５
グリチルレチン酸ステアリル ０．０５
Ｌ−アルギニン ０．１
ローヤルゼリーエキス ０．１
酢酸トコフェロール ０．１
アセチル化ヒアルロン酸ナトリウム ０．１
エデト酸三ナトリウム ０．０５
４−ｔ−ブチル−４’−メトキシジベンゾイルメタン ０．１
パラメトキシ桂皮酸２−エチルヘキシル ０．１
カルボキシビニルポリマー ０．１５
精製水 残余
Example 7 Latex Mass%
Liquid paraffin 7.0
Vaseline 3.0
Decamethylcyclopentasiloxane 2.0
Behenyl alcohol 1.0
Glycerin 5.0
Dipropylene glycol 7.0
Polyethylene glycol 1500 2.0
Stearyl dihydroxypropyl dimonium oligosaccharide 1.5
Jojoba oil 1.0
Isostearic acid 0.5
Stearic acid 0.5
Behenic acid 0.5
Tetra-2-ethylhexanoic acid pentaerythritol 3.0
Cetyl 2-ethylhexanoate 3.0
Glycerol monostearate 1.0
Polyoxyethylene glycerol monostearate 1.0
Potassium hydroxide 0.1
Sodium hexametaphosphate 0.05
Stearyl glycyrrhetinate 0.05
L-Arginine 0.1
Royal Jelly Extract 0.1
Tocopherol acetate 0.1
Acetylated sodium hyaluronate 0.1
Edetate trisodium 0.05
4-t-butyl-4'-methoxydibenzoylmethane 0.1
2-Ethylhexyl paramethoxycinnamate 0.1
Carboxyvinyl polymer 0.15
Purified water residue
実施例８ ジェル 質量％
９５％エタノール ５．０
ジプロピレングリコール １５．０
ＰＯＥ（５０）オレイルエーテル ２．０
カルボキシビニルポリマー １．０
水酸化ナトリウム ０．１５
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．３
香料 適量
精製水 残余
Example 8 Gel Mass%
95% ethanol 5.0
Dipropylene glycol 15.0
POE (50) oleyl ether 2.0
Carboxyvinyl polymer 1.0
Sodium hydroxide 0.15
Stearyl dihydroxypropyl dimonium oligosaccharide 0.3
Perfume Appropriate amount of purified water
実施例 ９ 美容液 質量％
９５％エタノール ５．０
ＰＯＥ（２０）オクチルドデカノール １．０
パントテニルエチルエーテル ０．１
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．３
水酸化カリウム ０．１
グリセリン ５．０
ジプロピレングリコール １０．０
亜硫酸水素ナトリウム ０．０３
カルボキシビニルポリマー ０．２
精製水 残余
Example 9 Essence Mass%
95% ethanol 5.0
POE (20) Octyldodecanol 1.0
Pantothenyl ethyl ether 0.1
Stearyl dihydroxypropyl dimonium oligosaccharide 0.3
Potassium hydroxide 0.1
Glycerin 5.0
Dipropylene glycol 10.0
Sodium bisulfite 0.03
Carboxyvinyl polymer 0.2
Purified water residue
実施例１０ パック 質量％
（Ａ相）
ジプロピレングリコール ５．０
ＰＯＥ（６０）硬化ヒマシ油 ５．０
（Ｂ相）
オリーブ油 ５．０
酢酸トコフェロール ０．２
香料 ０．２
（Ｃ相）
亜硫酸水素ナトリウム ０．０３
ポリビニルアルコール
(ケン化度９０，重合度２０００) １３．０
エタノール ５．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．３
精製水 残余
Example 10 Pack Mass%
(Phase A)
Dipropylene glycol 5.0
POE (60) hydrogenated castor oil 5.0
(Phase B)
Olive oil 5.0
Tocopherol acetate 0.2
Fragrance 0.2
(Phase C)
Sodium bisulfite 0.03
Polyvinyl alcohol
(Degree of saponification 90, degree of polymerization 2000) 13.0
Ethanol 5.0
Stearyl dihydroxypropyl dimonium oligosaccharide 0.3
Purified water residue
実施例１１ クリーム 質量％
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 １．０
ステアリルアルコール ３．５
ステアリン酸 ２．０
スクワラン １０．５
イソプロピルミリステート ７．５
ポリオキシエチレン（ＰＯＥ＝２５）セチルアルコールエーテル ３．０
モノステアリン酸グリセリン ２．０
酢酸トコフェロール ０．２
グリチルリチン酸モノアンモニウム ０．０５
グリセリン ３．０
ジプロピレングリコール ５．０
１，３−ブチレングリコール ３．０
フェノキシエタノール ０．２
エデト酸三ナトリウム ０．０１
精製水 残量
Example 11 Cream Mass%
Stearyl dihydroxypropyl dimonium oligosaccharide 1.0
Stearyl alcohol 3.5
Stearic acid 2.0
Squalane 10.5
Isopropyl myristate 7.5
Polyoxyethylene (POE = 25) cetyl alcohol ether 3.0
Glycerol monostearate 2.0
Tocopherol acetate 0.2
Monoammonium glycyrrhizinate 0.05
Glycerin 3.0
Dipropylene glycol 5.0
1,3-butylene glycol 3.0
Phenoxyethanol 0.2
Edetate trisodium 0.01
Purified water remaining
実施例１２ クリーム 質量％
ステアリン酸 ６．０
ソルビタンモノステアリン酸エステル ２．０
ＰＯＥ（２０）ソルビタンモノステアリン酸エステル １．５
エチルヘキサンジオール ２．０
プロピレングリコール １０．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．５
グリセリントリオクタノエート １０．０
スクワレン ５．０
亜硫酸水素ナトリウム ０．０１
香料 適量
精製水 残余
Example 12 Cream Mass%
Stearic acid 6.0
Sorbitan monostearate ester 2.0
POE (20) sorbitan monostearate ester 1.5
Ethylhexanediol 2.0
Propylene glycol 10.0
Stearyl dihydroxypropyl dimonium oligosaccharide 0.5
Glycerin trioctanoate 10.0
Squalene 5.0
Sodium bisulfite 0.01
Perfume Appropriate amount of purified water
実施例１３ クリーム 質量％
流動パラフィン １０．０
ジメチルポリシロキサン ２．０
グリセリン １０．０
１，３−ブチレングリコール ２．０
エリスリトール １．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 １．５
ポリエチレングリコール１５００ ５．０
スクワラン １５．０
水酸化カリウム ０．１
ヘキサメタリン酸ナトリウム ０．０５
酢酸トコフェロール ０．０５
ヒドロキシプロピルメチルセルロース ０．３
ポリビニルアルコール ０．１
カルボキシビニルポリマー ０．２
アクリル酸・メタクリル酸アルキル共重合体（ペミュレンＴＲ−２） ０．１
Example 13 Cream Mass%
Liquid paraffin 10.0
Dimethylpolysiloxane 2.0
Glycerin 10.0
1,3-butylene glycol 2.0
Erythritol 1.0
Stearyl dihydroxypropyl dimonium oligosaccharide 1.5
Polyethylene glycol 1500 5.0
Squalane 15.0
Potassium hydroxide 0.1
Sodium hexametaphosphate 0.05
Tocopherol acetate 0.05
Hydroxypropyl methylcellulose 0.3
Polyvinyl alcohol 0.1
Carboxyvinyl polymer 0.2
Acrylic acid / alkyl methacrylate copolymer (Pemulene TR-2) 0.1
実施例１４ クリーム 質量％
ワセリン ２．０
ジメチルポリシロキサン（6mPa.s） ２．０
エタノール ５．０
ベヘニルアルコール ０．５
バチルアルコール ０．２
グリセリン ７．０
１，３−ブチレングリコール ５．０
ポリエチレングリコール２００００ ０．５
ホホバ油 ３．０
スクワラン ２．０
ヒドロキシステアリン酸フィトステリル ０．５
ポリオキシエチレン（６０）硬化ヒマシ油 １．０
水酸化カリウム ０．１
ピロ亜硫酸ナトリウム ０．０１
ヘキサメタリン酸ナトリウム ０．０５
グリチルレチン酸ステアリル ０．１
パントテニルエチルエーテル ０．１
アルブチン ７．０
トラネキサム酸 １．０
酢酸トコフェロール ０．１
ヒアルロン酸ナトリウム ０．０５
エデト酸三ナトリウム ０．０５
エチルヘキサンジオール １．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．６
ジパラメトキシ桂皮酸モノ−２−エチルヘキサン
酸グリセリル ０．１
フェノキシエタノール ０．１
黄酸化鉄 適量
キサンタンガム ０．１
カルボキシビニルポリマー ０．２
精製水 残余
Example 14 Cream Mass%
Vaseline 2.0
Dimethylpolysiloxane (6mPa.s) 2.0
Ethanol 5.0
Behenyl alcohol 0.5
Batyl alcohol 0.2
Glycerin 7.0
1,3-butylene glycol 5.0
Polyethylene glycol 20000 0.5
Jojoba oil 3.0
Squalane 2.0
Phytosteryl hydroxystearate 0.5
Polyoxyethylene (60) hydrogenated castor oil 1.0
Potassium hydroxide 0.1
Sodium pyrosulfite 0.01
Sodium hexametaphosphate 0.05
Stearyl glycyrrhetinate 0.1
Pantothenyl ethyl ether 0.1
Arbutin 7.0
Tranexamic acid 1.0
Tocopherol acetate 0.1
Sodium hyaluronate 0.05
Edetate trisodium 0.05
Ethylhexanediol 1.0
Stearyl dihydroxypropyl dimonium oligosaccharide 0.6
Diparamethoxycinnamic acid mono-2-ethylhexanoate glyceryl 0.1
Phenoxyethanol 0.1
Yellow iron oxide xanthane gum 0.1
Carboxyvinyl polymer 0.2
Purified water residue
実施例１５ クリーム 質量％
デカメチルシクロペンタシロキサン ３０．０
ポリオキシエチレン・メチルポリシロキサン共重合体
（分子量6000） １．５
トリメチルシロキシケイ酸 ０．５
グリセリン ２．０
エチルヘキサンジオール １．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．８
ジプロピレングリコール ５．０
タルク ５．０
球状無水ケイ酸 ０．５
パルミチン酸デキストリン被覆微粒子酸化チタン（30nm） ７．０
球状ポリエチレン粉末 ２．０
ポリ（オキシエチレン・オキシプロピレン）
・メチルポリシロサン共重合体（分子量５５０００） １．０
フェノキシエタノール ０．２
エデト酸３ナトリウム ０．０２
ジメチルジステアリルアンモニウムヘクトライト ０．５
精製水 残余
Example 15 Cream mass%
Decamethylcyclopentasiloxane 30.0
Polyoxyethylene / methylpolysiloxane copolymer (molecular weight 6000) 1.5
Trimethylsiloxysilicate 0.5
Glycerin 2.0
Ethylhexanediol 1.0
Stearyl dihydroxypropyl dimonium oligosaccharide 0.8
Dipropylene glycol 5.0
Talc 5.0
Spherical silica 0.5
Palmitic acid dextrin coated fine particle titanium oxide (30nm) 7.0
Spherical polyethylene powder 2.0
Poly (oxyethylene / oxypropylene)
-Methyl polysilosan copolymer (molecular weight 55000) 1.0
Phenoxyethanol 0.2
Edetate trisodium 0.02
Dimethyl distearyl ammonium hectorite 0.5
Purified water residue
実施例１６ 洗顔料 質量％
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．５
３−ヘキシン−２，５−ジオール ０．１
ステアリン酸 ８．０
パルミチン酸 ６．０
ミリスチン酸 ６．０
ラウリン酸 ４．０
水酸化カリウム ５．２
グリセリルモノステアレート ２．０
プロピレングリコール １．０
ビースワックス １．５
ポリエチレングリコール１５００ ５．０
グリセリン １０．０
精製水 残量
Example 16 Face wash
Stearyl dihydroxypropyl dimonium oligosaccharide 0.5
3-Hexin-2,5-diol 0.1
Stearic acid 8.0
Palmitic acid 6.0
Myristic acid 6.0
Lauric acid 4.0
Potassium hydroxide 5.2
Glyceryl monostearate 2.0
Propylene glycol 1.0
Bees wax 1.5
Polyethylene glycol 1500 5.0
Glycerin 10.0
Purified water remaining
実施例１７ リンス 質量％
シリコーン油 ３．０
流動パラフィン １．０
セチルアルコール １．５
ステアリルアルコール １．０
塩化ステアリルトリメチルアンモニウム ０．７
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．４
グリセリン ３．０
色素 適量
香料 適量
精製水 残余
Example 17 Rinse Mass%
Silicone oil 3.0
Liquid paraffin 1.0
Cetyl alcohol 1.5
Stearyl alcohol 1.0
Stearyltrimethylammonium chloride 0.7
Stearyl dihydroxypropyl dimonium oligosaccharide 0.4
Glycerin 3.0
Dye Appropriate amount of perfume Appropriate amount of purified water
実施例１８ ゼリー状パック 質量％
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．１
ポリオキシエチレンオレイルアルコールエーテル ０．５
グリチルリチン酸モノアンモニウム ０．０５
カルボキシメチルセルロース ５．０
エタノール １２．０
ポリビニルアルコール １２．０
１，３−ブチレングリコール ５．０
エデト酸三ナトリウム ０．０１
精製水 残 量
Example 18 Jellied Pack Mass%
Stearyl dihydroxypropyl dimonium oligosaccharide 0.1
Polyoxyethylene oleyl alcohol ether 0.5
Monoammonium glycyrrhizinate 0.05
Carboxymethylcellulose 5.0
Ethanol 12.0
Polyvinyl alcohol 12.0
1,3-butylene glycol 5.0
Edetate trisodium 0.01
Purified water balance
実施例１９ 固形パウダリ−ファンデ−ション 質量％
タルク １５．０
セリサイト １０．０
球状ナイロン粉末 １０．０
多孔性無水ケイ酸粉末 １５．０
窒化ホウ素 ５．０
二酸化チタン ５．０
酸化鉄 ３．０
ステアリン酸亜鉛 ５．０
流動パラフィン 残余
トリイソオクタン酸グリセリン １５．０
セスキオレイン酸ソルビタン １．５
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．２
香料 適量
Example 19 Solid Powdery Foundation Mass%
Talc 15.0
Sericite 10.0
Spherical nylon powder 10.0
Porous silicic acid powder 15.0
Boron nitride 5.0
Titanium dioxide 5.0
Iron oxide 3.0
Zinc stearate 5.0
Liquid paraffin Residual glycerin triisooctanoate 15.0
Sorbitan sesquioleate 1.5
Stearyl dihydroxypropyl dimonium oligosaccharide 0.2
Perfume
実施例２０ 油中水型乳化ファンデ−ション 質量％
球状ナイロン １０．０
多孔性無水ケイ酸粉末 ８．０
雲母チタン ２．０
シリコーン処理セリサイト ２．０
シリコーン処理マイカ １２．０
シリコーン処理二酸化チタン ５．０
シリコーン処理酸化鉄 ２．０
精製水 残余
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．８
２，２−ジメチル−１−フェニル−１，３−プロパンジオール ０．２
３−ヘキシン−２，５−ジオール ０．１
デカメチルシクロペンタシロキサン １８．０
ジメチルポリシロキサン ５．０
スクワラン １．０
ポリオキシエチレン変性ジメチルポリシロキサン ２．０
香料 適量
Example 20 Water-in-oil type emulsification foundation Mass%
Spherical nylon 10.0
Porous silica powder 8.0
Mica titanium 2.0
Silicone-treated sericite 2.0
Silicone-treated mica 12.0
Silicone-treated titanium dioxide 5.0
Silicone-treated iron oxide 2.0
Purified water Residual stearyl dihydroxypropyl dimonium oligosaccharide 0.8
2,2-Dimethyl-1-phenyl-1,3-propanediol 0.2
3-Hexin-2,5-diol 0.1
Decamethylcyclopentasiloxane 18.0
Dimethylpolysiloxane 5.0
Squalane 1.0
Polyoxyethylene-modified dimethylpolysiloxane 2.0
Perfume
実施例２１ 白粉 質量％
タルク 残余
セリサイト １０．０
球状ナイロン粉末 １０．０
窒化ホウ素 ５．０
酸化鉄 ３．０
炭酸マグネシウム ５．０
スクワラン ３．０
トリイソオクタン酸グリセリン ２．０
セスキオレイン酸ソルビタン ２．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．４
香料 適量
Example 21 White powder% by mass
Talc Residual sericite 10.0
Spherical nylon powder 10.0
Boron nitride 5.0
Iron oxide 3.0
Magnesium carbonate 5.0
Squalane 3.0
Glycerin triisooctanoate 2.0
Sorbitan sesquioleate 2.0
Stearyl dihydroxypropyl dimonium oligosaccharide 0.4
Perfume
実施例２２ アイライナー 質量％
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 １．０
酸化鉄（黒） １４．０
イソプロピルミリステート １．５
ポリオキシエチレンソルビタンモノオレイン酸エステル １．０
酢酸ビニル樹脂エマルジョン ４５．０
グリチルリチン酸モノアンモニウム ０．０５
カルボキシビニルポリマー １．５
クエン酸アセチルトリブチル １．０
ジプロピレングリコール ４．０
イソプロピルアルコール １．０
エデト酸三ナトリウム ０．０１
精製水 残量
Example 22 Eyeliner Mass%
Stearyl dihydroxypropyl dimonium oligosaccharide 1.0
Iron oxide (black) 14.0
Isopropyl myristate 1.5
Polyoxyethylene sorbitan monooleate 1.0
Vinyl acetate resin emulsion 45.0
Monoammonium glycyrrhizinate 0.05
Carboxyvinyl polymer 1.5
Acetyltributyl citrate 1.0
Dipropylene glycol 4.0
Isopropyl alcohol 1.0
Edetate trisodium 0.01
Purified water remaining
実施例２３ アイシャド− 質量％
タルク 残余
マイカ １５．０
球状ナイロン粉末 １０．０
窒化ホウ素 ５．０
酸化鉄 ３．０
酸化チタン被覆マイカ ５．０
スクワラン ３．０
トリイソオクタン酸グリセリン ２．０
セスキオレイン酸ソルビタン ２．０
エチルヘキサンジオール １．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．６
香料 適量
Example 23 Eye Shadow-% by Mass
Talc Residual Mica 15.0
Spherical nylon powder 10.0
Boron nitride 5.0
Iron oxide 3.0
Titanium oxide coated mica 5.0
Squalane 3.0
Glycerin triisooctanoate 2.0
Sorbitan sesquioleate 2.0
Ethylhexanediol 1.0
Stearyl dihydroxypropyl dimonium oligosaccharide 0.6
Perfume
実施例２４ 口紅 質量％
カルナバロウ ０．５
キャンデリラロウ ５．０
セレシン １０．０
スクワラン 残余
トリイソステアリン酸グリセリン １０．０
ジイソステアリン酸グリセリン ２０．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．５
マカデミアナッツ油脂肪酸コレステリル ４．０
合成ケイ酸ナトリウム−マグネシウム ０．５
疎水性シリカ ０．５
精製水 ２．０
色剤 適量
香料 適量
Example 24 Lipstick mass%
Carnavalo 0.5
Candelilla Row 5.0
Ceresin 10.0
Squalane Residual glycerin triisostearate 10.0
Glycerin diisostearate 20.0
Stearyl dihydroxypropyl dimonium oligosaccharide 0.5
Macadamia nut oil fatty acid cholesteryl 4.0
Synthetic sodium silicate-magnesium 0.5
Hydrophobic silica 0.5
Purified water 2.0
Colorant Appropriate amount of perfume Appropriate amount
実施例２５ ヘアフォーム 質量％
（原液処方）
アクリル樹脂アルカノールアミン液（５０％） ８．０
ポリオキシエチレン硬化ヒマシ油 １．０
流動パラフィン ５．０
グリセリン ３．０
香料 適量
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．３
エタノール ５．０
精製水 残余
（充填処方）
原液 ９０．０
液化石油ガス １０．０
Example 25 Hair foam% by mass
(Stock solution formulation)
Acrylic resin alkanolamine solution (50%) 8.0
Polyoxyethylene hydrogenated castor oil 1.0
Liquid paraffin 5.0
Glycerin 3.0
Fragrance Appropriate amount Stearyl dihydroxypropyl dimonium oligosaccharide 0.3
Ethanol 5.0
Purified water residue (fill formula)
Stock solution 90.0
Liquefied petroleum gas 10.0
実施例２６ ヘアトニック 質量％
硬化ヒマシ油エチレンオキシド（４０モル）付加物 ２．０
エタノール ６０．０
香料 適 量
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．０１
精製水 残 量
Example 26 Hair tonic% by mass
Hardened castor oil ethylene oxide (40 mol) adduct 2.0
Ethanol 60.0
Fragrance Appropriate amount Stearyl dihydroxypropyl dimonium oligosaccharide 0.01
Purified water balance
実施例２７ 浴用剤 質量％
炭酸水素ナトリウム ６４．５
無水硫酸ナトリウム ３５．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．５
Example 27 Bath agent% by mass
Sodium bicarbonate 64.5
Anhydrous sodium sulfate 35.0
Stearyl dihydroxypropyl dimonium oligosaccharide 0.5
実施例２８ 中華めん 質量％
小麦粉 ９８．０
食塩 １．０
甘味料 ０．５
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．５
Example 28 Chinese noodles by mass
Wheat flour 98.0
Salt 1.0
Sweetener 0.5
Stearyl dihydroxypropyl dimonium oligosaccharide 0.5
実施例２９ めんつゆ液 質量％
醤油 ８０．７
酢 １．０
ブドウ糖 １５．０
グルタミン酸ソーダ ２．０
砂糖 １．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．３
Example 29 Mentsuyu liquid% by mass
Soy sauce 80.7
Vinegar 1.0
Glucose 15.0
Sodium glutamate 2.0
Sugar 1.0
Stearyl dihydroxypropyl dimonium oligosaccharide 0.3
実施例３０ そば 質量％
そば粉 ９６．０
食塩 ０．９
水 ３．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．１
Example 30 Buckwheat mass%
Buckwheat flour 96.0
Salt 0.9
Water 3.0
Stearyl dihydroxypropyl dimonium oligosaccharide 0.1
実施例３１ パン 質量％
小麦粉 ９０．０
食塩 １．２
砂糖 ２．０
水 ６．５
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．３
Example 31 Bread Mass%
Flour 90.0
Salt 1.2
Sugar 2.0
Water 6.5
Stearyl dihydroxypropyl dimonium oligosaccharide 0.3
実施例３２ ハム 質量％
ひき肉 ９５．０
鶏卵 ４．０
食塩 ０．５
香辛料 ０．４
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 ０．１
Example 32 Ham Mass%
Minced meat 95.0
Egg 4.0
Salt 0.5
Spice 0.4
Stearyl dihydroxypropyl dimonium oligosaccharide 0.1
実施例３３ 果汁飲料 質量％
ブドウ糖液糖 １３．０
オレンジ果汁 ８５．０
香料 １．０
ステアリルジヒドロキシプロピルジモニウムオリゴ糖 １．０
Example 33 Fruit juice mass%
Glucose liquid sugar 13.0
Orange juice 85.0
Fragrance 1.0
Stearyl dihydroxypropyl dimonium oligosaccharide 1.0
前記の実施例は、いずれも良好な防腐性を示した。 Each of the above examples showed good antiseptic properties.
本発明は、医薬品、医薬部外品、化粧品分野（人及びその他の動物用に用いる各種製剤も含む）の各種皮膚外用組成物に利用でき、具体的には、化粧水、乳液、クリーム（軟膏を含む）、サンスクリーン、ファンデーション、オイル、パック、石鹸（薬用石鹸も含む）、ボディソープ、口紅、爪化粧品、眉目化粧品、香水、洗顔料、口腔用類（歯磨き、マウスウオッシュ等）、防臭剤（腋臭、足臭等）、浴用剤、リンス、ヘアトニック、ヘアスプレー、染毛料などへの応用が上げられる。また、医療器具類や患部の消毒洗浄を目的とする医療用洗浄料、食器等を殺菌洗浄する家庭用洗浄料、食品工業用洗浄料などへの応用が上げられる。さらに、繊維製品（シーツ類、衣類等）、食品包装フィルム、合成樹脂、木材、日用品等の抗菌加工、各種形態の経口薬剤、衛生綿類、ウエットティシュや拭き取り用ペーパー類、除菌用クロス等の不織布に、又、口腔用組成物（ガム、キャンデー等）やかまぼこ、ちくわ等の水産ねり製品、ソーセージ、ハム等の畜産製品、洋菓子類、和菓子類、生めん、ゆでめん、中華めん、うどん、そば、スパゲッティー等のめん類、醤油、ソース、たれ等の調味料、惣菜、ジュース、スープ等、一般的な飲食類への利用可能性がある。
INDUSTRIAL APPLICABILITY The present invention can be used for various skin external compositions in the pharmaceutical, quasi-drug, and cosmetic fields (including various preparations used for humans and other animals). Specifically, lotions, emulsions, creams (ointments) ), Sunscreen, foundation, oil, pack, soap (including medicated soap), body soap, lipstick, nail cosmetics, eyebrow cosmetics, perfume, face wash, oral products (toothpaste, mouthwash, etc.), deodorant (Smell, foot odor, etc.), bath agents, rinses, hair tonics, hair sprays, hair dyes, etc. In addition, it can be applied to medical cleaning materials for the purpose of disinfecting and cleaning medical instruments and affected areas, household cleaning materials for sterilizing and cleaning dishes, and food industry cleaning materials. In addition, textile products (sheets, clothing, etc.), food packaging films, synthetic resins, wood, daily products, antibacterial processing, various forms of oral drugs, sanitary cotton, wet tissue, wipes, sanitizing cloth, etc. Non-woven fabric, marine products such as oral compositions (gum, candy, etc.), kamaboko, chikuwa, livestock products such as sausage, ham, Western confectionery, Japanese confectionery, raw noodles, boiled noodles, Chinese noodles, udon, soba , Spaghetti and other noodles, soy sauce, sauces, sauces and other seasonings, side dishes, juices, soups, etc.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004211140A JP2006028115A (en) | 2004-07-20 | 2004-07-20 | Antimicrobial agent |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004211140A JP2006028115A (en) | 2004-07-20 | 2004-07-20 | Antimicrobial agent |
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| Publication Number | Publication Date |
|---|---|
| JP2006028115A true JP2006028115A (en) | 2006-02-02 |
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|---|---|---|---|
| JP2004211140A Withdrawn JP2006028115A (en) | 2004-07-20 | 2004-07-20 | Antimicrobial agent |
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Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008517880A (en) * | 2004-10-25 | 2008-05-29 | ユニリーバー・ナームローゼ・ベンノートシヤープ | Personal care composition comprising a salt of dihydroxypropyltri (C1-C3 alkyl) ammonium monosubstituted polyol |
| WO2010029998A1 (en) * | 2008-09-11 | 2010-03-18 | ライオン株式会社 | Method for producing a monobenzyl ether of glycerol and/or a glycerol polymer, method for preventing yellowing, yellowing prevention agent, and buccal composition |
| JP2014502954A (en) * | 2010-09-22 | 2014-02-06 | イーコラブ ユーエスエー インコーポレイティド | Antibacterial composition comprising a cationic active ingredient and a surfactant derived from a quaternary sugar |
| JP2016050194A (en) * | 2014-09-02 | 2016-04-11 | 株式会社ナノカム | Sanitizer |
-
2004
- 2004-07-20 JP JP2004211140A patent/JP2006028115A/en not_active Withdrawn
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008517880A (en) * | 2004-10-25 | 2008-05-29 | ユニリーバー・ナームローゼ・ベンノートシヤープ | Personal care composition comprising a salt of dihydroxypropyltri (C1-C3 alkyl) ammonium monosubstituted polyol |
| WO2010029998A1 (en) * | 2008-09-11 | 2010-03-18 | ライオン株式会社 | Method for producing a monobenzyl ether of glycerol and/or a glycerol polymer, method for preventing yellowing, yellowing prevention agent, and buccal composition |
| JP2014502954A (en) * | 2010-09-22 | 2014-02-06 | イーコラブ ユーエスエー インコーポレイティド | Antibacterial composition comprising a cationic active ingredient and a surfactant derived from a quaternary sugar |
| JP2016155856A (en) * | 2010-09-22 | 2016-09-01 | エコラボ ユーエスエー インコーポレイティド | Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants |
| JP2017155053A (en) * | 2010-09-22 | 2017-09-07 | エコラボ ユーエスエー インコーポレイティド | Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants |
| US10624826B2 (en) | 2010-09-22 | 2020-04-21 | Ecolab Usa Inc. | Antimicrobial compositions containing cationic active ingredients and quaternary sugar derived surfactants |
| JP2016050194A (en) * | 2014-09-02 | 2016-04-11 | 株式会社ナノカム | Sanitizer |
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