JP2005270464A - Catheter for removing and sucking foreign matter inside blood vessel - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a catheter for removing and sucking foreign matters inside a blood vessel, capable of stripping an embolic material inside the blood vessel from the blood vessel without damaging the blood vessel and recovering the stripped foreign matter. <P>SOLUTION: The catheter 1 for removing and sucking the foreign matters inside the blood vessel comprises a wire-like member 3 provided with a loop part 31 for removing the foreign matter inside the blood vessel and a catheter tube 2 provided with a lumen 22 in the inside thereof, to which a suction means for sucking the inside of the lumen 22 can be connected. The surface of the loop part 31 is to be provided with lubricity when wetted. Further, the catheter 1 is provided with an operation part 5 capable of housing the wire-like member 3 for projecting the loop part 31 from the tip of the catheter tube 2 and moving it to the front and back in the axial direction of the catheter tube in the state of projecting it. <P>COPYRIGHT: (C)2006,JPO&NCIPI

Description

  The present invention relates to an intravascular foreign matter removing and aspiration catheter for removing a cause of stenosis in a blood vessel and collecting the removed material by suction.

  As a device for removing a thrombus or a foreign substance in a blood vessel, for example, a Foggy catheter of US Pat. No. 3,435,826 (Patent Document 1), an atheroma cutter of US Pat. No. 4,842,579 (Patent Document 2), etc. It has become. However, these have a complicated structure and a large diameter, and require a single guide catheter or a thick guide catheter, and cannot be used for a thin blood vessel. Japanese Patent No. 2620881 (Patent Document 3) discloses an intra-arterial extraction device having a wire loop. Those disclosed in these patent documents attempt to capture and remove foreign substances in blood vessels.

U.S. Pat. No. 3,435,826 US Pat. No. 4,842,579 Japanese Patent No. 2620881 JP 2003-10193 A

What is disclosed in the above-mentioned patent documents is intended to capture and remove foreign substances in blood vessels, and cannot sufficiently capture them. In addition, the applicant of the present application has proposed an intravascular foreign matter removing wire and a medical instrument disclosed in Japanese Patent Application Laid-Open No. 2003-10193 (Patent Document 4). Although this method has a sufficient effect, it is desired to be able to remove and collect intravascular foreign bodies more easily and reliably.
An object of the present invention is to provide an intravascular foreign matter removing and aspiration catheter that has a simple structure, can detach an embolus in a blood vessel from the blood vessel, and collect the removed foreign matter without damaging the blood vessel. There is.

What achieves the above object is as follows.
(1) Intravascular foreign matter removal comprising a wire-like member having a loop portion for removing foreign matter in a blood vessel, and a catheter tube having a lumen inside and connectable with suction means for sucking the inside of the lumen A suction catheter, wherein the surface of the loop portion is a surface having lubricity when wet, and the catheter can store the wire-like member, and the catheter tube of the loop portion A catheter for removing and sucking intravascular foreign matter, comprising an operation portion for projecting from the distal end of the tube and moving the catheter tube forward and rearward in the projected state.
(2) The intravascular foreign body removal suction according to (1) above, wherein the operation portion is configured by an operation member fixed to a wire-like member protruding from a rear end portion of the catheter tube. Catheter.
(3) The intravascular foreign matter removal according to (1) or (2), wherein the wire-like member includes the loop portion formed at the tip and a main body portion extending to the rear end side from the loop portion. Aspiration catheter.
(4) The intravascular foreign matter removal and suction catheter according to any one of (1) to (3), wherein the wire-like member includes a holding member that holds one end side and the other end side of the loop portion. .
(5) The wire member includes a holding member that holds one end side and the other end side of the loop portion, and the wire member is held by the holding member by twisting the wire member. The intravascular foreign matter removing and aspiration catheter according to any one of (1) to (3), wherein the length between the one end side and the other end side of the portion changes, and the size of the loop portion can be changed.
(6) The operation portion is fixed to a wire-like member at a portion protruding from the rear end portion of the catheter tube, and is configured by an operation member capable of performing the forward and backward movements and the twisting of the wire-like member. The catheter for removing and sucking intravascular foreign matter according to (5) above.

Moreover, what achieves the said objective is as follows.
(7) Intravascular foreign matter removal comprising a wire-like member having a loop portion for removing foreign matter in a blood vessel, and a catheter tube having a lumen inside and connectable with suction means for sucking the inside of the lumen In the suction catheter, the surface of the loop portion is a surface having lubricity when wet, and the loop portion is one end portion of the wire-like member fixed to the distal end portion of the catheter tube. And the main body part housed in the catheter tube, and the catheter is a loop part formed by sending the wire-like member to the distal end side of the catheter and pulling it back to the proximal end side. A catheter for removing and sucking intravascular foreign matter having an operation unit for changing the size of the blood vessel.
(8) The intravascular foreign matter removing and aspiration catheter according to (7), wherein the main body portion of the wire-like member is housed in the lumen of the catheter tube.
(9) The intravascular foreign matter removing and aspiration catheter according to (7), wherein the catheter tube includes a wire-shaped member housing lumen that houses the main body portion of the wire-shaped member.

Moreover, what achieves the said objective is as follows.
(10) Intravascular foreign matter removal comprising a wire-like member having a loop portion for removing foreign matter in a blood vessel, and a catheter tube having a lumen inside and connectable with suction means for sucking the inside of the lumen A suction catheter, wherein the wire-like member has a plurality of portions having different flexibility, and includes two main body portions that are folded back at the loop portion and extend in parallel to the rear end side of the catheter tube. The catheter further comprises a wire constituting the loop portion by feeding the two main body portions of the wire-like member to the distal end side of one catheter and pulling back the main body portion to the proximal end side of the other catheter. The wire-like member catheter is in a state of changing the part of the wire-like member and protruding from the distal end of the catheter tube of the loop portion. A catheter for removing and sucking intravascular foreign matter, which includes an operation unit for moving the tube forward and backward in the axial direction.
(11) In the blood vessel according to (10), at least a surface of a portion of the wire-like member that protrudes from a distal end of the catheter tube and can form a loop portion is a surface having lubricity when wet. Catheter for removing foreign substances.
(12) The catheter is provided in the catheter tube at a position closer to the proximal side than the suction means connecting portion, and the catheter tube is substantially liquid-tightly closed, and the wire-like member is liquid-tight. The intravascular foreign matter removing and aspiration catheter according to any one of the above (1) to (11), comprising a valve member slidable in a state.

The intravascular foreign matter removing and aspiration catheter of the present invention has a wire-like member having a loop part for removing foreign matter in a blood vessel, and a lumen inside, and suction means can be connected to suck the inside of the lumen. A catheter tube, and the surface of the loop portion is a surface having lubricity when wet, and the catheter can store the wire-like member, and the catheter of the loop portion. An operation unit is provided for projecting from the distal end of the tube and for moving the catheter tube forward and rearward in the projected state.
For this reason, in a state where the suction means is connected to the suction means connecting portion and operated, the foreign matter on the inner wall of the blood vessel is peeled and collected in the catheter tube without damaging the blood vessel by operating the operation portion. Can do.

Further, if the operation portion is constituted by an operation member fixed to a wire-like member in a portion protruding from the rear end portion of the catheter tube, the operation becomes easier.
The wire member includes a holding member that holds one end side and the other end side of the loop portion, and the wire member is held by the holding member by twisting the wire member. If the length between the one end side and the other end side is changed and the size of the loop portion can be changed, the size of the loop portion can be appropriately changed according to the situation.
Further, the operation portion is configured by an operation member that is fixed to a portion of the wire-like member protruding from the rear end portion of the catheter tube and capable of performing the forward and backward movements and the twisting of the wire-like member. If it is, the operation becomes easier.

The catheter for removing and sucking foreign matter in the blood vessel according to the present invention has a wire-like member having a loop part for removing foreign matter in the blood vessel, and a suction means connected to the lumen for suction inside the lumen. And the surface of the loop portion is a surface having lubricity when wet, and the loop portion is fixed to the distal end portion of the catheter tube. The wire-like member is formed between one end portion of the wire-like member and the main body portion accommodated in the catheter tube. Further, the catheter is fed to the distal end side of the catheter of the main-body portion of the wire-like member and the proximal end side. An operation unit is provided for changing the size of the loop part by pulling back.
For this reason, in a state where the suction means is connected to the suction means connecting portion and operated, the foreign matter on the inner wall of the blood vessel is peeled and collected in the catheter tube without damaging the blood vessel by operating the operation portion. Can do.

The catheter for removing and sucking foreign matter in the blood vessel according to the present invention has a wire-like member having a loop part for removing foreign matter in the blood vessel, and a suction means connected to the lumen for suction inside the lumen. The wire-like member has a plurality of portions having different flexibility, and is folded back at the loop portion and extends in parallel to the rear end side of the catheter tube 2. A main body portion of the book, and the catheter further sends out the two main body portions of the wire-like member to the distal end side of one catheter and pulls the main body portion back to the proximal end side of the other catheter. In order to change the wire-like member portion constituting the loop portion and in the state of protruding from the distal end of the catheter tube of the loop portion, And an operation unit for performing forward and backward in the axial direction of the catheter tube sagittal members.
For this reason, the flexibility of the loop portion can be changed as appropriate according to the situation, and the blood vessel is damaged by operating the operation unit in a state where the suction unit is connected to the suction unit connection unit and operated. The foreign matter on the inner wall of the blood vessel can be peeled off and collected in the catheter tube without any trouble.
The catheter is provided in the catheter tube at a position closer to the proximal end than the suction means connecting portion, and the catheter tube is substantially liquid-tightly closed, and the wire-like member is liquid-tight. If the valve member is provided with a slidable valve member, it is possible to maintain the suction state by the suction means and prevent blood leakage.

Therefore, the intravascular foreign matter removing and aspiration catheter of the present invention will be described with reference to the embodiments shown in the drawings.
FIG. 1 is a partially omitted external view of an embodiment of an intravascular foreign matter removal and suction catheter according to the present invention. FIG. 2 is an enlarged view of the distal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 3 is an enlarged cross-sectional view of the proximal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 4 is an enlarged cross-sectional view of the proximal end portion of another embodiment of the catheter for removing intravascular foreign matter of the present invention. FIG. 5 is an explanatory view for explaining the operation of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 6 is an explanatory view for explaining the operation of the intravascular foreign matter removing and aspiration catheter shown in FIG.
An intravascular foreign matter removing and aspiration catheter 1 according to the first embodiment of the present invention has a wire-like member 3 having a loop portion 31 for removing foreign matter in a blood vessel, a lumen 22 inside, and the inside of the lumen 22. And a catheter tube 2 to which suction means can be connected for suction. The surface of the loop portion 31 is a surface having lubricity when wet, and the catheter 1 can store the wire-like member 3, and the loop portion 31 protrudes and protrudes from the distal end of the catheter tube 2. The operation unit 5 is provided for moving the catheter tube forward and rearward in the axial direction in this state.

As shown in FIG. 1, the intravascular foreign matter removing and aspiration catheter 1 of this embodiment constitutes a catheter tube 2, a wire-like member 3, and an operation portion 5 fixed to the rear end portion of the wire-like member 3. An operation member. And the catheter tube 2 consists of the tube main body 21 and the hub 4 fixed to the rear-end part. In addition, the operation part may be constituted by a wire-like member that protrudes from the rear end of the catheter tube 2.
The tube body 21 of the catheter tube 2 is a cylindrical body including a lumen 22 penetrating from the front end to the rear end, and is formed of a flexible material. As the tube main body 21, the outer diameter is preferably about 1.0 to 3.0 mm, more preferably about 1.4 to 2.7 mm, and the inner diameter is about 0.5 to 2.7 mm. The length is preferably about 1.1 to 2.4 mm, and the length is preferably about 500 to 2000 mm, more preferably about 800 to 1500 mm.
The tube main body 21 is made of, for example, polyolefin such as polypropylene and polyethylene, and olefin-based elastomer (for example, polyethylene elastomer and polypropylene elastomer), polyester and polyester elastomer such as polyethylene terephthalate, soft polyvinyl chloride, polyurethane and urethane-based elastomer, polyamide and amide. It is formed of a flexible polymer material such as a base elastomer (for example, polyamide elastomer), polytetrafluoroethylene and fluororesin elastomer, polyimide, ethylene-vinyl acetate copolymer, silicone rubber, or the like.

The hub 4 is a so-called branch hub, and includes a hub main body 41 provided with the suction means connecting portion 6, a cylindrical member 42 fixed to the rear end portion of the hub main body 41, and a valve member 45 accommodated in the hub main body. I have. The inside of the hub 4 communicates with a lumen 22 formed in the tube main body 21, and the suction means connecting portion 6 communicates with the lumen 22.
The valve member 45 is provided in the catheter tube (specifically, in the hub) at a position closer to the base end side than the suction means connection portion 6, and closes the catheter tube substantially in a liquid-tight manner. The member 3 can be slid in a liquid-tight state. Specifically, the valve member 45 is housed in the rear end portion of the hub main body 41, and substantially between the front end portion of the tubular member 42 that has entered the rear end portion of the hub main body 41 and the hub main body 41. It is held immovable. The valve member 45 allows passage and sliding of the wire-like member 3 and prevents passage of liquid. Specifically, the valve member has a cut or a hole through which a wire-like member can be inserted. Further, natural or synthetic rubber or elastomer can be used as the material for forming the valve member. Further, a lubricant may be applied or coated on the contact portion of the valve member with the wire-like member. Examples of the lubricant include a hydrophilic polymer and silicone oil.

The cylindrical member 42 accommodates a distal end side portion 5a of the operation member 5 to be described later so as to be slidable in the axial direction, and an axially extending slit 43 for slidably accommodating the projection 5b of the operation member 5. The locking member 44 is provided for preventing the operation member 5 from being detached from the cylindrical member. The protrusion 5 b of the operation member 5 contacts the locking portion 44.
As a material for forming the hub main body 41 and the cylindrical member 42, thermoplastic resins such as polycarbonate, polyamide, polysulfone, polyarylate, and methacrylate-butylene-styrene copolymer can be suitably used.
As shown in FIG. 2, the wire-like member 3 includes a loop portion 31 formed at the front end and a main body portion extending from the loop portion 31 toward the rear end side. Furthermore, in this embodiment, as shown in FIG. 2, a loop portion forming member 32 is provided. Further, the rear end of the wire-like member 3 protrudes from the rear end of the catheter tube 2. The loop portion forming member 32 includes a first hole for holding the distal end portion of the wire-like member 3 and a second hole for holding the rear end portion of the loop portion. And the wire-shaped member 3 is provided with the latching | locking part 3a which penetrates the 1st hole and bends. In addition, the loop portion may be formed by fixing or winding one end of the wire-like member 3 to a proximal end portion of a predetermined distance from one end of the wire-like member without providing the loop portion forming member 32. Further, a loop portion may be formed by forming a ring-shaped portion or a coil-shaped portion by one end portion of the wire-shaped member 3 and passing a portion on the proximal end side by a predetermined distance from one end of the wire-shaped member. . The loop portion of the type described above has a constant size.

  The shape of the loop portion may be a perfect circle or an elliptical polygon. As a magnitude | size of the loop part 31, when it is a perfect circle shape, it is preferable that it is 0.5-5.0 mm in diameter, More preferably, it is 1.5-4.0 mm. In the case of an elliptical or polygonal shape, the length (the length in the direction parallel to the axial direction) is preferably 3 to 30 mm, more preferably 5 to 20 mm, and the width (axial direction). Is preferably 0.5 to 5.0 mm, and more preferably 1.5 to 4.0 mm. The wire-like member 3 has a wire diameter of 0.1 mm to 1.5 mm and a length of 700 mm to 3000 mm, preferably 1000 mm to 2000 mm.

As a forming material of the wire-like member, an elastic metal wire, a coil pair, and a fiber body are preferable. In particular, an elastic metal wire is suitable because it can be made thin. Examples of the elastic metal used for the elastic metal wire include stainless steel (for example, SUS304), β titanium steel, Co—Cr alloy, piano wire, platinum-iridium alloy (Pt90 / Ir10, Pt80 / Ir20, etc.) and other noble metals. Various metal materials such as an alloy having spring properties such as a spring alloy and a nickel titanium alloy are preferable. As the fibrous body, mono-multi fibers made of resin are preferable. Further, as the wire-like member, the loop portion forming portion and the main body portion (in other words, the portion other than the loop portion forming portion) may have different elasticity. In this case, it is conceivable to use a body having a certain degree of hardness in order to enhance the movement response of the wire-like member in the axial direction, and to make the loop part more flexible than the body.
Furthermore, a super elastic alloy wire may be used as the wire member. A superelastic alloy is an alloy having a wide elastic region that does not undergo plastic deformation even when the tensile strain is about 8%. For example, a Ni-Ti alloy, a Cu-Al-Ni alloy, a Cu-Zn-Al alloy, etc. Superelastic materials are preferred. Moreover, it is preferable that the front end side (loop part) of the wire-shaped member 3 is flexible.

Furthermore, the outer surface of the loop portion 31 of the wire-like member 3 is a lubricious surface that reduces frictional resistance when wet (in other words, when in contact with blood). The whole wire-like member 3 may be a lubricious surface.
In order to obtain a lubricious surface, for example, a lubricity imparting agent is coated. The thickness is preferably about several microns to several hundred microns. As the lubricity imparting agent, a water-soluble polymer substance or a derivative thereof is preferable. For example, poly (2-hydroxyethyl methacrylate), polyhydroxyethyl acrylate, a cellulose-based polymer substance (for example, hydroxypropylcellulose, hydroxyethylcellulose), Maleic anhydride polymer (eg, methyl vinyl ether maleic anhydride copolymer), acrylamide polymer (eg, polyacrylamide), polyethylene oxide polymer (eg, polyethylene oxide, polyethylene glycol), polyvinyl alcohol Polyacrylic acid polymer materials (eg, polyacrylic acid soda), phthalic acid polymer materials (eg, polyhydroxyethyl phthalate), water-soluble polyesters (eg, polydimethyl ether) Propionic acid ester), a ketone aldehyde resin (e.g., methyl isopropyl ketone formaldehyde), polyvinyl pyrrolidone, polyethylene imine, polystyrene sulfonate, and water-soluble nylon can be used.

  Furthermore, it is preferable that the lubricity imparting agent does not easily peel or flow out. For this reason, it is preferable to coat the outer surface of the loop portion of the wire-like member or the entire wire-like member with a compound having a coat-forming property (film-forming property). By providing a film of this film-forming compound, the adhesion of the imparting agent is improved as compared with coating the lubricity imparting agent on the wire-like member. Furthermore, it is preferable to use a compound having a reactive functional group as the film-forming compound. A film of such a compound having a reactive functional group is first formed on the outer surface of the wire-like member, and a water-soluble polymer substance or a derivative thereof as a lubricity imparting agent is ionically bonded to the reactive functional group of the compound. Alternatively, it is preferable that a water-soluble polymer substance or a derivative thereof is coated on the film of the compound by covalent bonding. The above-mentioned substances can be preferably used as the water-soluble polymer substance or derivative thereof.

  As the reactive functional group, an isocyanate group, an amino group, an aldehyde group, an epoxy group, and the like are preferable. Therefore, as a compound having a reactive functional group and having a film forming property (film forming property), polyurethane is used. Polyamide and the like are preferable. Furthermore, in order to increase the reactive functional group, it is preferable to mix a substance having a reactive functional group in the compound. Such materials include isocyanates such as ethylene diisocyanate, hexanemethylene diisocyanate, xylene diisocyanate, toluene diisocyanate, diphenylmethane diisocyanate, and adducts or prepolymers of these isocyanates and polyols, polyamines (eg, low molecular weight polyamines, ethylenediamine, trimethylenediamine). And high molecular weight polyamine) glutaraldehyde.

  Further, as a coating method, a substance having a reactive functional group [for example, a solution of polyurethane (tetrahydrofuran solution)] and a substance having a reactive functional group [for example, a solution of 4,4′diphenylmethane diisocyanate (methyl ethyl ketone solution)] After contacting the coating site (the outer surface of the core metal core 2) with the mixture of, dried, and contacted with a water-soluble polymer [for example, a solution of methyl vinyl ether maleic anhydride copolymer (methyl ethyl ketone solution)], This can be done by drying. By doing so, lubricity can be imparted to the surface of the guide wire, and the lubricity can be maintained for a long time.

  The operation member 5 is fixed to the rear end of the catheter tube 2, specifically, to the rear end portion of the wire-like member protruding from the hub body 41. As described above, the distal end portion 5a of the operation member 5 is accommodated in the cylindrical member 42 so as to be movable in the axial direction. Furthermore, the protrusion 5 b of the operation member 5 can move in the slit 43 of the cylindrical member 42 until it comes into contact with the locking portion 44 of the operation member 5. As the material for forming the operation member, a thermoplastic resin such as polycarbonate, polyamide, polysulfone, polyarylate, and methacrylate-butylene-styrene copolymer can be suitably used.

As described above, in the catheter of this embodiment, the operation member slides in the axial direction so as not to rotate. For this reason, a loop part can be stably moved to an axial direction. In addition, it is not limited to such a thing, As shown in FIG. 4, the member for operation may be rotatable and can slide to an axial direction. The only difference between this embodiment and that described above is that the slit of the cylindrical member and the protrusion of the operation member are not provided. In this embodiment, a rib (preferably an annular rib) is provided on the distal end side surface of the distal end portion 5a of the operating member, and this rib abuts on the locking portion 44 of the cylindrical member 42. Separation from the tubular member is prevented.
Then, by pushing the operation member 5 forward in the axial direction of the catheter tube, the loop portion 31 protrudes away from the distal end of the catheter tube, as shown by a broken line in FIG. For this reason, when the operation member 5 is operated forward and backward in the axial direction, the loop portion 31 moves forward and backward in the axial direction of the catheter tube 2 in a state of protruding from the distal end of the catheter tube 2. For this reason, the foreign substance adhering to the blood vessel inner wall is peeled off.
Furthermore, as shown in FIG. 5, by pulling the operation member 5 rearward in the axial direction of the catheter tube until the projection 5b comes into contact with the locking portion 44 of the tubular member 42, as shown in FIG. The wire-shaped member 3 also moves rearward in the axial direction of the catheter tube, and the loop portion 31 is accommodated in the catheter tube 2 (tube body 22).

Next, an intravascular foreign matter removing and aspiration catheter according to another embodiment of the present invention will be described.
FIG. 7 is a partially omitted external view of another embodiment of the catheter for removing foreign substances in blood vessels according to the present invention. FIG. 8 is an enlarged view of the distal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 9 is an enlarged cross-sectional view of the distal end portion of another embodiment of the catheter for removing intravascular foreign matter of the present invention. FIG. 10 is an enlarged cross-sectional view of the distal end portion of another embodiment of the catheter for removing foreign substances in blood vessels according to the present invention. 11 is an enlarged cross-sectional view of the proximal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG.
The basic structure of the intravascular foreign matter removal and suction catheter 10 of this embodiment is the same as that of the intravascular foreign matter removal and suction catheter 1 described above. The difference is that the wire-like member 3 has one end side and the other end of the loop portion. The wire-like member 3 includes a holding member 32 for holding the side, and the length between one end side and the other end side of the loop portion held by the holding member 32 is changed by twisting the wire-like member 3. Only the point that the size of 31 can be changed and the operation part can advance, retreat and twist the wire-like member, only the differences will be described, and the same components will be described above. Refer to the explanation of.

As shown in FIG. 7, the intravascular foreign matter removing and aspiration catheter 10 of this embodiment constitutes a catheter tube 2, a wire-like member 3, and an operation portion 15 fixed to the rear end portion of the wire-like member 3. An operation member. And the catheter tube 2 consists of the tube main body 21 and the hub 14 fixed to the rear-end part.
As the catheter tube 2, those described above can be preferably used.
As shown in FIG. 11, the hub 14 is a so-called branch hub, and includes a hub main body 41 including the suction means connecting portion 6, a cylindrical member 42 fixed to the rear end portion of the hub main body 41, and the hub main body. A accommodated valve member 45 is provided. The inside of the hub 14 communicates with a lumen 22 formed in the tube main body 21, and the suction means connecting portion 6 communicates with the lumen 22.
The valve member 45 is provided in the catheter tube (specifically, in the hub) at a position closer to the base end side than the suction means connection portion 6, and closes the catheter tube substantially in a liquid-tight manner. The member 3 can be slid in a liquid-tight state. Specifically, the valve member 45 is housed in the rear end portion of the hub main body 41, and substantially between the front end portion of the tubular member 42 that has entered the rear end portion of the hub main body 41 and the hub main body 41. It is held immovable. As the valve member 45, those described above are preferably used.

The cylindrical member 42 accommodates a distal end portion of the shaft member 17 which will be described later so as to be slidable in the axial direction, and an axially extending slit 43 that slidably accommodates the projection 18 of the shaft member 17, and the shaft member 17 is provided with a locking portion 44 for preventing separation from the 17 cylindrical members. The protrusion 18 of the shaft member 17 abuts on the locking portion 44.
As a material for forming the hub main body 41 and the cylindrical member 42, thermoplastic resins such as polycarbonate, polyamide, polysulfone, polyarylate, and methacrylate-butylene-styrene copolymer can be suitably used.

  As shown in FIG. 8, the wire-like member 3 includes a loop portion 31 formed at the front end and a main body portion extending from the loop portion 31 toward the rear end side. Furthermore, in this embodiment, as shown in FIG. 8, a loop portion forming member 32 is provided. Further, the rear end of the wire-like member 3 protrudes from the rear end of the catheter tube 2. The loop portion forming member 32 includes a first hole for holding the distal end portion of the wire-like member 3 and a second hole for holding the rear end portion of the loop portion. And the wire-shaped member 3 is provided with the latching | locking part 3a which penetrates the 1st hole and bends. Furthermore, the helical engagement portion 3b (specifically, the outer surface of the loop portion forming member 32 in the vicinity of the second hole, in other words, the outer surface of the rear end side of the predetermined distance from the tip of the wire-like member) , A spiral rib), and the inner surface of the second hole of the loop portion forming member 32 is a spiral engagement portion 32a (specifically, screwable with the spiral engagement portion 3b). , A spiral recess). For this reason, by twisting the wire-like member 3 in a predetermined direction, the spiral rib 3b portion of the wire-like member 32 advances forward, and between the one end side and the other end side of the loop portion held by the holding member 32. The length is increased, and the size of the loop portion 31 is increased. Further, by twisting the wire-like member 3 in the direction opposite to the predetermined direction, the spiral rib 3b portion of the wire-like member 32 advances backward, and one end side and the other end of the loop portion held by the holding member 32 The length between the sides is shortened, and the size of the loop portion 31 is reduced.

  Further, the configuration of the wire-like member 3 may be as shown in FIG. In the wire-like member 3 shown in FIG. 9, the distal end portion of the wire-like member 3 is rotatably held in the first hole of the loop portion forming member 32. Ring-shaped members 33 and 34 are provided in the first hole of the loop-forming member 32 to rotatably hold the wire-like member. A bulging portion 3c for preventing the member from coming off is formed. 8, the outer surface of the loop forming member 32 in the vicinity of the second hole, in other words, the outer surface of the portion on the rear end side of the predetermined distance from the tip of the wire-like member. A helical engagement portion 3b (specifically, a helical rib) is provided, and the inner surface of the second hole of the loop portion forming member 32 can be screwed with the helical engagement portion 3b. A spiral engagement portion 32a (specifically, a spiral recess) is provided. By twisting the wire-like member 3 in a predetermined direction, the spiral rib 3b portion of the wire-like member 32 advances forward, and the length between one end side and the other end side of the loop portion held by the holding member 32 is reduced. It becomes longer and the size of the loop part 31 becomes larger. Further, by twisting the wire-like member 3 in the direction opposite to the predetermined direction, the spiral rib 3b portion of the wire-like member 32 advances backward, and one end side and the other end of the loop portion held by the holding member 32 The length between the sides is shortened, and the size of the loop portion 31 is reduced. When the wire-like member is twisted, the tip of the wire-like member 3 is rotatably held in the first hole of the loop portion forming member 32, so that the wire-like member itself rotates. However, the twist caused by twisting does not remain in the loop portion.

  Further, the configuration of the wire-like member 3 may be as shown in FIG. The wire-like member 3 shown in FIG. 10 is provided with a bent portion 3a and a spiral portion 3d for preventing the loop-like member from coming off from the tip. In this embodiment, the spiral portion 3 d is accommodated in the first hole of the loop portion forming member 32. 8, the outer surface of the loop forming member 32 in the vicinity of the second hole, in other words, the outer surface of the portion on the rear end side of the predetermined distance from the tip of the wire-like member. A helical engagement portion 3b (specifically, a helical rib) is provided, and the inner surface of the second hole of the loop portion forming member 32 can be screwed with the helical engagement portion 3b. A spiral engagement portion 32a (specifically, a spiral recess) is provided. By twisting the wire-like member 3 in a predetermined direction, the spiral rib 3b portion of the wire-like member 32 advances forward, and the length between one end side and the other end side of the loop portion held by the holding member 32 is reduced. It becomes longer and the size of the loop part 31 becomes larger. Further, by twisting the wire-like member 3 in the direction opposite to the predetermined direction, the spiral rib 3b portion of the wire-like member 32 advances backward, and one end side and the other end of the loop portion held by the holding member 32 The length between the sides is shortened, and the size of the loop portion 31 is reduced. When the wire-like member is twisted, the twist is absorbed by the spiral portion (coil-like portion), so that the twist due to the twist remains less in the loop portion.

As described above, when the size of the loop portion can be changed, the shape of the loop portion may be either a perfect circle or an elliptical polygon. The minimum size of the loop portion 31 is preferably 0.5 to 2.5 mm in diameter in the case of a perfect circle, more preferably 1 to 2 mm, and the maximum size. In the case of a perfect circle, the diameter is preferably 2.6 to 5 mm, and more preferably 3 to 4 mm. In the case of an elliptical or polygonal shape, the minimum length (the length in the direction parallel to the axial direction) is preferably 3 to 10 mm, more preferably 5 to 8 mm. The width in the small time (the length in the direction orthogonal to the axial direction) is preferably 0.5 to 2.5 mm, more preferably 1 to 2 mm, and the maximum length (parallel to the axial direction). The length in the direction) is preferably 20 to 30 mm, more preferably 22 to 28 mm, and the maximum width (the length in the direction perpendicular to the axial direction) is 3 to 5 mm. Preferably, it is 3.5 to 4.5 mm. The wire-like member 3 has a wire diameter of 0.1 mm to 1.5 mm and a length of 700 mm to 3000 mm, preferably 1000 mm to 2000 mm.
As the material for forming the wire-like member, those described above can be used.

Furthermore, the outer surface of the loop portion 31 of the wire-like member 3, in the case of this embodiment, at least the outer surface of the portion that can be the loop portion is a lubricious surface that reduces the frictional resistance when wet (in other words, at the time of blood contact). ing. The whole wire-like member 3 may be a lubricious surface. The lubricating surface is the same as described above.
The operation member 15 is fixed to the rear end of the catheter tube 2, specifically, the rear end portion of the wire-like member protruding from the hub body 41. The operation member 15 includes a shaft member 17 and a rotation member 16 fixed to the rear end portion of the wire-like member 3 and rotatably attached to the rear end portion of the shaft member 17. The shaft member 17 includes a passage penetrating the wire-like member 3 therein, and is accommodated in the cylindrical member 42 of the hub 14 so as to be movable in the axial direction. Further, the protrusion 18 of the shaft member 17 can move in the slit 43 of the cylindrical member 42 until it comes into contact with the locking portion 44 of the cylindrical member 42.

Then, when the operation member 15 is pushed forward in the axial direction of the catheter tube, the loop portion 31 protrudes away from the distal end of the catheter tube, as shown by the broken line in FIG. For this reason, when the operation member 15 is operated forward and backward in the axial direction, the loop portion 31 moves forward and backward in the axial direction of the catheter tube 2 in a state of protruding from the distal end of the catheter tube 2. For this reason, the foreign substance adhering to the blood vessel inner wall is peeled off. Further, similar to that shown in FIG. 5, the operation member 15 is pulled in the axial direction rearward of the catheter tube until the projection 15 b comes into contact with the locking portion 44 of the tubular member 42. Similarly, the wire-like member 3 also moves rearward in the axial direction of the catheter tube, and the loop portion 31 is accommodated in the catheter tube 2 (tube body 22).
Further, a helical engagement portion 17 a (specifically, a helical rib) is provided at the rear end portion of the shaft member 17, and the above-described helical engagement is provided at the distal end portion of the rotating member 16. A helical engagement portion 15a (specifically, a helical recess) that is screwed with the portion 17 is provided. For this reason, when the rotating member 16 is rotated in a predetermined direction, the wire-shaped member 3 fixed to the rotating member 16 is twisted, and the rotating member 16 and the wire-shaped member 3 are moved forward in the axial direction of the catheter. Move to. When the rotating member 16 is rotated in the direction opposite to the predetermined direction, the wire member 3 fixed to the rotating member 16 is twisted, and the rotating member 16 and the wire member 3 are connected to the catheter. Move backward in the axial direction. The pitch of the helical engagement portions 15a and 17a of the operation member (specifically, the rotating member 16 and the shaft member 17) is set on the outer surface of the rear end side of the predetermined distance from the tip of the wire-like member 3 described above. The formed helical engagement portion 3b (specifically, helical rib) and the helical engagement portion 32a (specifically, spiral) provided on the inner surface of the second hole of the loop portion forming member 32. It is preferable that the pitch is substantially the same as the pitch of the concave portions).

Next, an intravascular foreign matter removing and aspiration catheter according to another embodiment of the present invention will be described.
FIG. 12 is a partially omitted external view of another embodiment of the intravascular foreign matter removing and aspiration catheter of the present invention. FIG. 13 is an enlarged view of the distal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. 14 is an enlarged cross-sectional view of the proximal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG.
An intravascular foreign matter removal suction catheter 50 of this embodiment has a wire-like member 3 having a loop portion 31 for removing foreign matter in a blood vessel, a lumen 22 inside, and suction for sucking the inside of the lumen 22. A catheter tube 2 to which the means can be connected. Further, the surface of the loop portion 31 of the catheter 50 is a surface having lubricity when wet, and the loop portion 31 further includes one end portion 36 of the wire-like member 3 fixed to the distal end portion of the catheter tube 2. The catheter 50 is formed between the main body portions 37 accommodated in the catheter tube 2, and the catheter 50 is a loop portion by feeding the main body portion 37 of the wire-like member 3 to the distal end side of the catheter and pulling it back to the proximal end side. An operation unit 55 for changing the size of 31 is provided.

In the catheter 50 of this embodiment, the main body portion 37 of the wire-like member 3 is accommodated in the lumen 22 of the catheter tube 2.
As shown in FIG. 12, the catheter 50 for removing intravascular foreign matter of this embodiment constitutes a catheter tube 2, a wire-like member 3, and an operation portion 55 fixed to the rear end portion of the wire-like member 3. An operation member. And the catheter tube 2 consists of the tube main body 21 and the hub 51 fixed to the rear-end part. In addition, the operation part may be constituted by a wire-like member that protrudes from the rear end of the catheter tube 2.
The tube body 21 of the catheter tube 2 is a cylindrical body including a lumen 22 penetrating from the front end to the rear end, and is formed of a flexible material. The tube body 21 preferably has an outer diameter of about 1 to 3 mm, more preferably about 1.4 to 2.7 mm, and an inner diameter of about 0.5 to 2.7 mm. More preferably, it is about 1.1-2.4 mm, and it is preferable that length is about 500-2000 mm, More preferably, it is about 800-1500 mm. As the material for forming the tube main body 21, those described above are used.

  As shown in FIGS. 12 and 14, the hub 51 is a so-called branch hub, and includes a hub main body 52 having the suction means connecting portion 6, a cap 54 fixed to the rear end portion of the hub main body 52, and the inside of the hub main body. And a valve member 53 housed in the housing. The inside of the hub 51 communicates with the lumen 22 formed in the tube main body 21, and the suction means connecting portion 6 communicates with the lumen 22. The valve member 53 is provided in the catheter tube (specifically, in the hub 51) at a position closer to the proximal end side than the suction means connection portion 6, and closes the catheter tube substantially liquid-tightly. The wire-like member 3 can be slid in a liquid-tight state. Specifically, the valve member 53 is housed in the rear end portion of the hub main body 52, and substantially between the front end portion of the inner cylindrical portion of the cap 54 that has entered the rear end portion of the hub main body 52 and the hub main body 52. Is kept immovable. The valve member 53 allows passage and sliding of the wire-like member 3 and prevents passage of liquid. Specifically, the valve member has a cut or a hole through which a wire-like member can be inserted. The valve member 53 shown in the figure includes a tip tapered portion that decreases in diameter toward the distal end side and a tapered lumen that decreases in diameter toward the distal end side. As the material for forming the valve member, natural or synthetic rubber or elastomer can be used. Further, a lubricant may be applied or coated on the contact portion of the valve member with the wire-like member. Examples of the lubricant include a hydrophilic polymer and silicone oil. As the material for forming the hub main body 52 and the cap 54, thermoplastic resins such as polycarbonate, polyamide, polysulfone, polyarylate, and methacrylate-butylene-styrene copolymer can be suitably used.

As shown in FIG. 13, the wire-like member 3 includes a loop portion 31 formed at the front end and a main body portion extending from the loop portion 31 toward the rear end side. Furthermore, in this embodiment, as shown in FIG. 13, one end portion 36 of the wire-like member 3 is fixed to the inner surface of the distal end portion of the catheter tube 2 by a fixing material 25. And the main-body part 37 of the wire-shaped member 3 used as a base end from the loop part 31 is accommodated in the lumen | rumen 22 of the catheter tube 2 so that sliding is possible. For this reason, the size of the loop portion 31 is changed by feeding the wire-like member 3 toward the distal end side of the catheter and pulling it back toward the proximal end side.
The shape of the loop portion may be a perfect circle or an elliptical polygon. The minimum size of the loop portion 31 is preferably 0.5 to 2.5 mm in diameter in the case of a perfect circle, more preferably 1 to 2 mm, and the maximum size. In the case of a perfect circle, the diameter is preferably 2.6 to 5 mm, and more preferably 3 to 4 mm. In the case of an elliptical or polygonal shape, the minimum length (the length in the direction parallel to the axial direction) is preferably 3 to 10 mm, more preferably 5 to 8 mm. The width in the small time (the length in the direction orthogonal to the axial direction) is preferably 0.5 to 2.5 mm, more preferably 1 to 2 mm, and the maximum length (parallel to the axial direction). The length in the direction) is preferably 20 to 30 mm, more preferably 22 to 28 mm, and the maximum width (the length in the direction perpendicular to the axial direction) is 3 to 5 mm. Preferably, it is 3.5 to 4.5 mm. The wire-like member 3 has a wire diameter of 0.1 mm to 1.5 mm and a length of 700 mm to 3000 mm, preferably 1000 mm to 2000 mm.
The material for forming the wire-like member is the same as described above.

And the outer surface of the part which can become the loop part 31 of the wire-like member 3 is a lubricating surface in which the frictional resistance is reduced when wet (in other words, when in contact with blood). The whole wire-like member 3 may be a lubricious surface. The lubricating surface is the same as described above.
And in the catheter 50 of this Example, as shown in FIG. 14, the operation part 55 is equipped with the function for performing sending out to the front end side of the catheter of the wire-like member 3, and pulling back to the proximal end side. .
Specifically, the operation unit 55 includes an operation unit housing 56, an operation wheel 58 housed in the operation unit housing, a driven wheel 57 that rotates by the rotation of the operation wheel 58, and a hub 51 (specifically, Includes a member 59a for attaching to the cap 54) and a rear end member 59b. The two wheels 58 and 59 are accommodated in the housing 56 so that the circumferential side surfaces thereof are close to each other and hold the wire-like member 3 under pressure. Furthermore, the side surfaces on the circumference of the wheels 58 and 59 may be provided with engaging portions (specifically, ribs or concave portions) for gripping and feeding the wire-like member 3. Further, the outer surface of the rear end portion of the wire-like member 3 may include an engaging portion (specifically, a recess or a rib) that can be engaged with the engaging portion. The operation wheel 58 is partially exposed from the housing 56, and the wheel is rotated in the exposed portion. In the operation portion 55 of this embodiment, the wire 58 is pushed to the distal end side by rotating the wheel 58 toward the rear end side of the catheter, and as shown by the solid line or the front broken line in FIG. 31 is exposed from the tip of the catheter tube 2 and expands. Conversely, by rotating the wheel 58 toward the distal end side of the catheter, the wire-like member 3 is pulled back toward the rear end side, and the loop portion 31 is reduced, and finally the rear end in FIG. As indicated by the broken line on the side, the loop portion 31 is accommodated in the lumen of the catheter tube 2.

Next, an intravascular foreign matter removing and aspiration catheter according to another embodiment of the present invention will be described.
FIG. 15 is a partially omitted external view of another embodiment of the catheter for removing foreign substances in blood vessels according to the present invention. 16 is an enlarged perspective view of the distal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. 17 is an enlarged front view of the distal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. 18 is an enlarged cross-sectional view of the proximal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG.
An intravascular foreign matter removing and suctioning catheter 60 of this embodiment has a wire-like member 62 having a loop portion 62a for removing foreign matter in a blood vessel, a lumen 22 inside, and suction for sucking the inside of the lumen 22. A catheter tube 2 to which the means can be connected. Furthermore, the surface of the loop portion 62a of the catheter 60 is a surface having lubricity when wet, and the loop portion 62a is connected to one end portion 62b of the wire-like member 62 fixed to the distal end portion of the catheter tube 2. The catheter 60 is formed between the main body portions 62c accommodated in the catheter tube 2, and the catheter 60 is a loop portion by feeding the main body portion 62c of the wire-like member 62 to the distal end side of the catheter and pulling it back to the proximal end side. An operation unit 80 for changing the size of 62a is provided.

In the catheter 60 of this embodiment, the main body portion 62 c of the wire-like member 62 is housed in a wire-like member housing lumen provided separately from the lumen 22 of the catheter tube 2.
As shown in FIG. 15, the catheter 60 for removing intravascular foreign matter according to this embodiment includes a catheter tube 2, a first wire-like member 62, a second wire-like member 63, and a wire-like member 62. A first operating portion 80 for operating the end portion and a second operating portion 90 for operating the rear end portion of the wire-like member 63 are provided. And the catheter tube 2 consists of the tube main body 21 and the hub 64 fixed to the rear-end part. In addition, in this Example, although two wire-shaped members and those operation parts are provided, only one side may be sufficient. Furthermore, the operation part may be constituted by a wire-like member that protrudes from the rear end of the catheter tube 2.

  The tube body 21 of the catheter tube 2 is a cylindrical body including a lumen 22 penetrating from the front end to the rear end, and is formed of a flexible material. The tube body 21 preferably has an outer diameter of about 1 to 3 mm, more preferably about 1.4 to 2.7 mm, and an inner diameter of about 0.5 to 2.7 mm. More preferably, it is about 1.1-2.4 mm, and it is preferable that length is about 500-2000 mm, More preferably, it is about 800-1500 mm. As the material for forming the tube main body 21, those described above are used.

  As shown in FIGS. 15 and 18, the hub 64 is a hub having two branch portions, and is fixed to one of the hub main body 65 including the suction means connecting portion 6 and the rear end branch portion of the hub main body 65. A cap 66a, a valve member 67a housed in one of the rear end branch portions of the hub body 65, a cap 66b fixed to the other of the rear end branch portions of the hub body 65, and a rear end branch portion of the hub body 65. And a valve member 67b housed in the other. The inside of the hub 64 communicates with the main lumen 22 formed in the tube main body 21, and the suction means connecting portion 6 communicates with the lumen 22. The valve members 67a and 67b are provided in the catheter tube (specifically, in the hub 64) at a portion closer to the base end side than the suction means connection portion 6, and close the catheter tube substantially liquid-tightly. The wire-like members 62 and 63 can be slid in a liquid-tight state. Specifically, the valve members 67a and 67b are housed in the respective rear end branch portions of the hub body 65, and the cap members 66a and 66b that have entered the respective end portions of the rear end branch portion of the hub main body 65 are included. It is substantially immovably held between the distal end portion of the cylindrical portion and the hub main body 65. The valve members 67a and 67b allow passage and sliding of the wire-like members 62 and 63 and prevent passage of liquid. Specifically, the valve member has a cut or a hole through which a wire-like member can be inserted. In addition, the valve members 67a and 67b shown in the figure are provided with a tip tapered portion that is reduced in diameter toward the tip end side and a tapered lumen that is reduced in diameter toward the tip end side. As the material for forming the valve member, natural or synthetic rubber or elastomer can be used. Further, a lubricant may be applied or coated on the contact portion of the valve member with the wire-like member. Examples of the lubricant include a hydrophilic polymer and silicone oil. As the material for forming the hub main body 65 and the caps 66a and 66b, thermoplastic resins such as polycarbonate, polyamide, polysulfone, polyarylate, and methacrylate-butylene-styrene copolymer can be suitably used.

  As shown in FIGS. 16 and 17, the first wire-like member 62 includes a loop portion 62a formed at the tip, and a main body portion 62c extending to the rear end side from the loop portion 62a. Furthermore, in this embodiment, as shown in FIGS. 16 and 17, one end portion 62 b of the wire-like member 62 is fixed to the distal end portion of the catheter tube 2 by the fixing material 25. And the main-body part 62c of the wire-shaped member 62 used as a base end from the loop part 62a is accommodated in the wire-shaped member accommodation lumen 26 formed in the thickness of the catheter tube 2 so that sliding is possible. For this reason, the size of the loop portion 62a is changed by feeding the wire-like member 62 toward the distal end side of the catheter and pulling it back toward the proximal end side.

  As shown in FIGS. 16 and 17, the second wire-like member 63 is formed at the tip, and the loop portion 63 a provided so as to cross over the loop portion 62 a of the first wire-like member 62, A main body 63c extending from the loop 63a to the rear end side is provided. Further, in this embodiment, as shown in FIGS. 16 and 17, one end portion 63 b of the wire-like member 63 is fixed to the distal end portion of the catheter tube 2 by a fixing material (not shown). The main body portion 63c of the wire-like member 63, which is the base end of the loop portion 63a, is slidable in a second wire-like member storage lumen (not shown) formed in the wall thickness of the catheter tube 2. It is stored in. For this reason, the size of the loop portion 63a is changed by feeding the wire-like member 63 toward the distal end side of the catheter and pulling it back toward the proximal end side.

The shape of the loop portions 62a and 63a may be a perfect circle or an elliptical polygon. As a minimum size of the loop portion, in the case of a perfect circle, the diameter is preferably 0.5 to 2.5 mm, more preferably 1 to 2 mm, and the maximum size is In the case of a perfect circle, the diameter is preferably 2.6 to 5 mm, and more preferably 3 to 4 mm. In the case of an elliptical or polygonal shape, the minimum length (the length in the direction parallel to the axial direction) is preferably 3 to 10 mm, more preferably 5 to 8 mm. The width in the small time (the length in the direction orthogonal to the axial direction) is preferably 0.5 to 2.5 mm, more preferably 1 to 2 mm, and the maximum length (parallel to the axial direction). The length in the direction) is preferably 20 to 30 mm, more preferably 22 to 28 mm, and the maximum width (the length in the direction perpendicular to the axial direction) is 3 to 5 mm. Preferably, it is 3.5 to 4.5 mm. The wire-like members 62 and 63 have a wire diameter of 0.1 mm to 1.5 mm and a length of 700 mm to 3000 mm, preferably 1000 mm to 2000 mm.
The material for forming the wire-like member is the same as described above.
And the outer surface of the part which can become the loop parts 62a and 63a of the wire-like members 62 and 63 is a lubricious surface in which frictional resistance is reduced when wet (in other words, at the time of blood contact). The entire wire-like member may be a lubricious surface. The lubricating surface is the same as described above.

And in the catheter 60 of this Example, as shown in FIG.15 and FIG.18, the operation parts 80 and 90 send out the wire-like members 62 and 63 to the front end side of the catheter, and pull back to the proximal end side. It has a function for.
Specifically, the operation unit 80 for the first wire-like member 62 includes an operation unit housing 81, an operation wheel 83 housed in the operation unit housing, and a follower that rotates by the rotation of the operation wheel 83. A wheel 84, a member 86 for mounting to a hub 64 (specifically, a cap 66a), and a rear end member 87 are provided. The two wheels 83 and 84 are accommodated in the housing 81 so that the circumferential side surfaces thereof are close to each other and hold the wire-like member 62 with pressure. Furthermore, the side surfaces on the circumference of the wheels 83 and 84 may be provided with engaging portions (specifically, ribs or concave portions) for gripping and feeding the wire-like member 62. Further, the outer surface of the rear end portion of the wire-like member 62 may include an engaging portion (specifically, a recess or a rib) that can be engaged with the engaging portion. The operation wheel 83 is partially exposed from the housing 81, and the wheel is rotated in the exposed portion. In the operation unit 80 of this embodiment, by rotating the wheel 83 to the rear end side of the catheter, the wire-like member 62 is pushed out to the front end side, and the loop portion 62a is enlarged. Conversely, by rotating the wheel 83 toward the distal end side of the catheter, the wire-like member 62 is pulled back toward the rear end side, and the loop portion 62a is reduced.

Similarly, the operation unit 90 for the second wire-shaped member 63 includes an operation unit housing 91, an operation wheel 93 housed in the operation unit housing, and a driven wheel 94 that rotates by the rotation of the operation wheel 93. And a member 96 for mounting to the hub 64 (specifically, the cap 66b) and a rear end member 97. The two wheels 93 and 94 are accommodated in the housing 91 so that the circumferential side surfaces thereof are close to each other and hold the wire-like member 63 under pressure. Further, on the circumferential side surfaces of the wheels 93 and 94, an engaging portion (specifically, a rib or a concave portion) for gripping and feeding the wire-like member 63 may be provided. Further, the outer surface of the rear end portion of the wire-like member 63 may include an engaging portion (specifically, a recess or a rib) that can be engaged with the engaging portion. The operation wheel 93 is partially exposed from the housing 91, and the wheel is rotated in the exposed portion. In the operation unit 90 of this embodiment, by rotating the wheel 93 to the rear end side of the catheter, the wire-like member 63 is pushed out to the front end side, and the loop portion 63a is enlarged. Conversely, by rotating the wheel 93 toward the distal end side of the catheter, the wire-like member 63 is pulled back toward the rear end side, and the loop portion 63a is reduced.
As a material for forming the housing and the wheel, a hard or semi-rigid resin such as polycarbonate, polyamide, polysulfone, polyarylate, methacrylate-butylene-styrene copolymer, or a metal material (for example, stainless steel, titanium alloy) is preferable. Can be used.

Next, an intravascular foreign matter removing and aspiration catheter according to another embodiment of the present invention will be described.
FIG. 19 is a partially omitted external view of an embodiment of the catheter for removing intravascular foreign matter according to the present invention. 20 is an enlarged cross-sectional view of the distal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 21 is an enlarged view of the proximal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. 22 is an enlarged cross-sectional view of the proximal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 23 is an enlarged cross-sectional view of a proximal end portion of another embodiment of the catheter for removing intravascular foreign matter of the present invention. FIG. 24 is an explanatory diagram for explaining the action of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 25 is an explanatory diagram for explaining the action of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 26 is an explanatory diagram for explaining an example of a wire-like member used in the intravascular foreign matter removal and suction catheter of the present invention. FIG. 27 is an enlarged cross-sectional view of the distal end portion of another embodiment of the catheter for removing intravascular foreign matter of the present invention.

An intravascular foreign matter removing and aspiration catheter 100 of this embodiment has a wire-like member 3 having a loop portion 31 for removing foreign matters in a blood vessel, a lumen 22 inside, and suction for sucking the lumen 22. A catheter tube 2 to which the means can be connected. The wire-like member 3 has a plurality of portions A1, A2, and A3 having different flexibility, and is folded back at the loop portion 31 and includes two main body portions 38 and 39 extending in parallel to the rear end side of the catheter tube. Prepare. Furthermore, the catheter 100 feeds the two main body portions 38, 39 of the wire-like member 3 to the distal end side of one catheter and pulls the main body portions 38, 39 back to the proximal end side of the other catheter, thereby making a loop portion. In order to change the part of the wire-like member 31 constituting 31 and the protrusion of the loop portion 31 from the distal end of the catheter tube 2 and the advancement of the wire-like member 3 in the axial direction of the catheter tube 2 in the protruding state of the loop portion 31 And an operation unit 150 for retreating.
In the catheter 100 of this embodiment, the operation unit 150 sends and retracts one of the two main body portions 38 and 39 of the wire-like member 3 to the distal end side of the catheter and the other catheter of the main body portion 38 and 39. Can be pulled back to the base end side and sent out to the front end side. Furthermore, in the catheter 100 of this embodiment, the operation unit 150 has a function for moving the wire-like member 3 itself forward and backward in the axial direction of the catheter tube.

As shown in FIG. 19, the catheter 100 for removing intravascular foreign matter of this embodiment includes a catheter tube 2, a wire-like member 3, and an operation unit 150 for operating the wire-like member 3 at the rear end. And an operation member to be configured.
And the catheter tube 2 consists of the tube main body 21 and the hub 140 fixed to the rear-end part. The operation unit 150 may be configured by a wire-like member that protrudes from the rear end of the catheter tube 2.
The tube body 21 of the catheter tube 2 is the same as described above.
The hub 140 is a so-called branch hub as shown in FIGS. 19, 21, and 22, and includes a hub main body 141 having the suction means connecting portion 6 and a cylindrical member 142 fixed to the rear end portion of the hub main body 141. And a valve member 145 housed in the hub body. The inside of the hub 140 communicates with the lumen 22 formed in the tube main body 21, and the suction means connecting portion 6 communicates with the lumen 22.

The valve member 145 is provided in the catheter tube (specifically, in the hub) at a position closer to the proximal end than the suction means connecting portion 6, and closes the catheter tube substantially liquid-tightly. The two main body portions of the shaped member 3 can be slid in a liquid-tight state. Specifically, the valve member 145 is housed in the rear end portion of the hub main body 141, and substantially between the front end portion of the tubular member 142 that has entered the rear end portion of the hub main body 141 and the hub main body 141. It is held immovable. The valve member 145 allows passage and sliding of each body portion of the wire-like member 3 and prevents passage of liquid. As the valve member 145, the thing similar to the valve member 45 mentioned above is used.
The cylindrical member 142 accommodates a distal end side portion 152a of the operation member 150, which will be described later, so as to be slidable in the axial direction, and an axially extending slit 143 that accommodates the protrusion 156 of the operation member 150 slidably. The locking member 144 is provided to prevent the operation member 150 from being detached from the cylindrical member 142. When the operation member 150 is pulled rearward, the projection 156 contacts the locking portion 144.

As the forming material of the hub main body 141 and the cylindrical member 142, thermoplastic resins such as polycarbonate, polyamide, polysulfone, polyarylate, methacrylate-butylene-styrene copolymer can be suitably used.
As shown in FIGS. 19 and 20, the wire-like member 3 includes a loop portion 31 formed at the tip, and two main body portions 38 and 39 extending from the loop portion 31 toward the rear end side. As shown in FIG. 26, the wire-like member 3 used in this embodiment has a plurality of portions A1, A2, and A3 having different flexibility, and the first region A1, the first region A2, and the second region A3. The flexibility increases in the order of the three regions A3. That is, the region A3 is the most flexible, the region A1 is the hardest, and the region A2 has an intermediate flexibility. Note that the flexibility is not stepwise, and the flexibility may gradually increase from the region A1 toward the region A3. The number of regions having different flexibility is not limited to the above three and is preferably about 2 to 5. And the wire-shaped member 3 in this Example is an endless complete loop shape. The wire-like member is not limited to such an endless member, and may have two free ends exposed from the operation unit.

  Further, the wire-like member 3 in this embodiment has a first display area S1 that makes a pair with the first area A1, a second display area S2 that makes a pair with the second area A2, and a third area that makes a pair with the third area A3. A display area S3 is provided. These display areas are exposed from the operation unit 150 in a state where the loop part 31 is configured by a pair of area parts. For this reason, by making the first display area S1, the second display area S2, and the third display area S3 identifiable, it is possible to easily confirm in which area the loop portion 31 is configured. As a method for distinguishing the first display area S1, the second display area S2, and the third display area S3, it is possible to apply different colors or patterns, or to change the outer surface shape.

The shape of the loop portion 31 may be a perfect circle or an elliptical polygon. As the size of the loop portion 31, in the case of a perfect circle, the maximum diameter is preferably 0.5 to 5 mm, and more preferably 1.5 to 4.5 mm. In the case of an elliptical or polygonal shape, the maximum length (the length in the direction parallel to the axial direction) is preferably 3 to 30 mm, more preferably 5 to 20 mm. The width of time (the length in the direction orthogonal to the axial direction) is preferably 0.5 to 5.0 mm, more preferably 1.5 to 4 mm. The wire-like member 3 has a wire diameter of 0.1 mm to 1.5 mm and a length of 1200 mm to 6000 mm, preferably 1800 mm to 4000 mm.
The material for forming the wire-like member is the same as described above.
The outer surface of the portion that can become the loop portion 31 of the wire-like member 3 (the portions A1, A2, and A3 having different flexibility in the above-described embodiments) has a reduced frictional resistance when wet (in other words, when in contact with blood). It has a lubricious surface. The entire wire-like member may be a lubricious surface. The lubricating surface is the same as described above.

  Then, as shown in FIGS. 19, 21, and 22, an operation member 150 for operating the rear end of the catheter tube 2, specifically, the rear end portion of the wire-like member 31 protruding from the hub body 41. Is provided. As described above, the distal end portion 152a of the operation member 150 is accommodated in the cylindrical member 142 so as to be movable in the axial direction. Further, the protrusion 156 of the operation member 150 can move in the slit 143 of the cylindrical member 142 until it comes into contact with the locking portion 144 of the cylindrical member 142. As described above, in the catheter of this embodiment, the operation member slides in the axial direction so as not to rotate. For this reason, a loop part can be stably moved to an axial direction. In addition, it is not limited to such a thing, As shown in FIG. 23, the member for operation may be rotatable and can slide to an axial direction. The only difference between this embodiment and that described above is that the slit of the cylindrical member and the protrusion of the operation member are not provided. In this embodiment, a rib (preferably an annular rib) is provided on the distal end side surface of the distal end portion 152a of the operation member, and this rib comes into contact with the locking portion 144 of the cylindrical member 142. Separation from the tubular member is prevented.

  Specifically, as shown in FIG. 22, the operation unit 150 includes a first follower that rotates due to the rotation of the operation unit housing 152, the operation wheel 155 housed in the operation unit housing, and the operation wheel 155. A wheel 153 and a second driven wheel 154 and a rotating member 151 connected to the operation wheel 155 are provided as shown in FIG. The operation wheel 155 and the driven wheel 153 are close to each other on the circumferential side, and hold the body portion 38 of the wire-like member 3 under pressure. Also, the operation wheel 155 and the driven wheel 154 The side surfaces on the circumference are close to each other, and hold the main body 39 of the wire-like member 3 under pressure. The central protrusion 152b of the housing 152 is provided to reliably separate the main body portions 38 and 39 of the wire-like member 3. On the circumferential side surfaces of the wheels 153, 154, 155, engagement portions (specifically, ribs or recesses) for ensuring the feeding and withdrawal of the main body portions 38, 39 of the wire-like member 3 are provided. ) May be provided. Further, the outer surface of the main body of the wire-like member 3 may be provided with an engaging portion (specifically, a recess or a rib) that can be engaged with the engaging portion. The rotation member 151 is provided on the surface of the housing 152 as shown in FIG. The turning member 151 includes a knob 151a for turning operation.

As the forming material of the operation housing, the wheel and the rotating member, polycarbonate, polyamide, polysulfone, polyarylate, a hard or semi-rigid resin such as a methacrylate-butylene-styrene copolymer, and a metal material (for example, stainless steel, (Titanium alloy) can be preferably used.
In the operation unit 150 of this embodiment, when the rotating member 151 is rotated to the upper side of the arrow in FIG. 21 (wheel 153 side), the wheel 153 in FIG. 24 moves the main body 39 of the wire-like member 3 backward. While rotating in the direction (in other words, pulling back), the wheel 154 rotates in the direction of moving (in other words, pushing out) the main body 38 of the wire-like member 3 forward. Thereby, the wire-like member 3 rotates like an endless belt within the catheter. And the part of the wire-like member which comprises the loop part 31 changes sequentially by the movement of this wire-like member 3. For this reason, a loop part can be comprised by the site | part provided with the softness | flexibility according to the objective. Further, the rear end portion of the wire-like member 3 is exposed from the operation portion 150, and the flexible region constituting the loop portion can be confirmed by confirming the above-described display region appearing in the exposed portion. .

Furthermore, the protrusion of the loop part and the size of the loop part can be adjusted by moving the operation part 150 itself forward and backward in the axial direction of the catheter. Specifically, in the state where the operation unit is located at the rearmost position in FIG. 24, the loop portion is in the state indicated by the innermost broken line in FIG. 20 and is accommodated in the catheter tube 2. When the operation unit 150 is pushed forward by a predetermined distance, the loop portion protrudes from the catheter tube as indicated by a broken line in FIG. Then, when the operation unit is pushed in until the tip of the operation unit comes into contact with the cylindrical member, a state shown by a solid line in FIG. 20 is obtained, and the loop portion expands and the tip position thereof also moves forward. For this reason, when the operation member 150 is operated forward and backward in the axial direction, the loop portion 31 moves forward and backward in the axial direction of the catheter tube 2 in a state of protruding from the distal end of the catheter tube 2. For this reason, the foreign substance adhering to the blood vessel inner wall is peeled off.
Further, the wire-like member 3 may be as shown in FIG. The wire-like member 3 in this embodiment includes a loop portion forming member 32. The loop portion forming member 32 includes a first hole for holding one end side of the loop portion of the wire-like member 3 and a second hole for holding the other end side of the loop portion. By providing the loop portion forming member 32, the size of the loop portion does not change. Except this point, it is the same as the catheter 100 of the embodiment described above.

  The shape of the loop portion in this embodiment may be a perfect circle or an elliptical polygon. The size of the loop portion 31 is preferably 0.5 to 5 mm in diameter in the case of a perfect circle, and more preferably 1.5 to 4.5 mm. In the case of an elliptical or polygonal shape, the length (the length in the direction parallel to the axial direction) is preferably 3 to 30 mm, more preferably 5 to 20 mm, and the width (axial direction). The length in the direction perpendicular to the angle is preferably 0.5 to 5 mm, and more preferably 1.5 to 4 mm. The wire-like member 3 has a wire diameter of 0.1 mm to 1.5 mm and a length of 1100 mm to 4200 mm, preferably 1700 mm to 3200 mm.

  In this embodiment, the operation portion 150 itself is moved forward and backward in the axial direction of the catheter so that the loop portion 31 is separated from the distal end of the catheter tube while maintaining the same size. Protrusively. For this reason, when the operation member 150 is operated forward and backward in the axial direction, the loop portion 31 moves forward and backward in the axial direction of the catheter tube 2 in a state of protruding from the distal end of the catheter tube 2. For this reason, the foreign substance adhering to the blood vessel inner wall is peeled off. Furthermore, the loop member 31 is housed in the catheter tube 2 (tube body 22) by completely pulling the operation member 150 in the axially rearward direction of the catheter tube.

And the structure at the time of use of the intravascular foreign matter removal suction catheter of this invention is demonstrated using drawing.
FIG. 28 is an explanatory diagram for explaining an example of a state in which suction means is attached to the intravascular foreign matter removal suction catheter of the present invention.
A syringe 110 that is a suction means is attached to the suction means connection portion of the catheter 1 for removing and removing intravascular foreign matter. And in the state attracted | sucked with the syringe, by operating the operation part 5 back and forth in the axial direction of a catheter, while the foreign material adhering to the blood vessel inner wall is peeled off, a foreign material is extract | collected in the catheter tube 2 .
FIG. 29 is an explanatory diagram for explaining another example of the state in which the suction means is attached to the catheter for removing intravascular foreign matter according to the present invention.
A suction device 120 is attached to the suction means connecting portion of the intravascular foreign matter removing suction catheter 1 via a tube 121. And in the state which attracted | sucked the lumen | rumen of the catheter tube 2 to the predetermined pressure with the suction device 120, while operating the operation part 5 back and forth in the axial direction of a catheter, while the foreign material adhering to the blood vessel inner wall is peeled off, Is collected in the catheter tube 2. For example, a constant pressure suction pump can be used as the suction device 120.
The above-described configuration of the intravascular foreign matter removing and aspirating catheter has been described using the intravascular foreign matter removing and aspirating catheter 1, but the same can be applied to the catheters of all the above-described embodiments.

FIG. 1 is a partially omitted external view of an embodiment of an intravascular foreign matter removal and suction catheter according to the present invention. FIG. 2 is an enlarged view of the distal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 3 is an enlarged cross-sectional view of the proximal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 4 is an enlarged cross-sectional view of the proximal end portion of another embodiment of the catheter for removing intravascular foreign matter of the present invention. FIG. 5 is an explanatory view for explaining the operation of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 6 is an explanatory view for explaining the operation of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 7 is a partially omitted external view of another embodiment of the catheter for removing foreign substances in blood vessels according to the present invention. FIG. 8 is an enlarged view of the distal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 9 is an enlarged cross-sectional view of the distal end portion of another embodiment of the catheter for removing intravascular foreign matter of the present invention. FIG. 10 is an enlarged cross-sectional view of the distal end portion of another embodiment of the catheter for removing foreign substances in blood vessels according to the present invention. 11 is an enlarged cross-sectional view of the proximal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 12 is a partially omitted external view of another embodiment of the intravascular foreign matter removing and aspiration catheter of the present invention. FIG. 13 is an enlarged view of the distal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. 14 is an enlarged cross-sectional view of the proximal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 15 is a partially omitted external view of another embodiment of the catheter for removing foreign substances in blood vessels according to the present invention. 16 is an enlarged perspective view of the distal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. 17 is an enlarged front view of the distal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. 18 is an enlarged cross-sectional view of the proximal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 19 is a partially omitted external view of an embodiment of the catheter for removing intravascular foreign matter according to the present invention. 20 is an enlarged cross-sectional view of the distal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 21 is an enlarged view of the proximal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. 22 is an enlarged cross-sectional view of the proximal end portion of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 23 is an enlarged cross-sectional view of a proximal end portion of another embodiment of the catheter for removing intravascular foreign matter of the present invention. FIG. 24 is an explanatory diagram for explaining the action of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 25 is an explanatory diagram for explaining the action of the intravascular foreign matter removing and aspiration catheter shown in FIG. FIG. 26 is an explanatory diagram for explaining an example of a wire-like member used in the intravascular foreign matter removal and suction catheter of the present invention. FIG. 27 is an enlarged cross-sectional view of the distal end portion of another embodiment of the catheter for removing intravascular foreign matter of the present invention. FIG. 28 is an explanatory diagram for explaining an example of a state in which suction means is attached to the intravascular foreign matter removal suction catheter of the present invention. FIG. 29 is an explanatory diagram for explaining another example of the state in which the suction means is attached to the catheter for removing foreign substance in blood vessel of the present invention.

Explanation of symbols

DESCRIPTION OF SYMBOLS 1 Catheter for removal of foreign substances in blood vessel 2 Catheter tube 3 Wire-like member 31 Loop part 5 Operation part 6 Suction means connection part

Claims (12)

An intravascular foreign matter removal and suction catheter comprising a wire-like member having a loop portion for removing foreign matter in a blood vessel, and a catheter tube having a lumen inside and connectable with suction means for sucking the inside of the lumen. The surface of the loop portion is a surface having lubricity when wet, and the catheter can store the wire-like member and from the tip of the catheter tube of the loop portion. A catheter for removing and sucking intravascular foreign matter, comprising an operation section for moving the catheter tube forward and rearward in the axial direction in the protruding state and the protruding state. 2. The intravascular foreign matter removing and aspiration catheter according to claim 1, wherein the operation portion is configured by an operation member fixed to a wire-like member in a portion protruding from a rear end portion of the catheter tube. 3. The intravascular foreign matter removing and aspiration catheter according to claim 1, wherein the wire-like member includes the loop portion formed at a distal end and a main body portion extending from the loop portion toward the rear end side. The intravascular foreign matter removing and aspiration catheter according to any one of claims 1 to 3, wherein the wire-like member includes a holding member that holds one end side and the other end side of the loop portion. The wire member includes a holding member that holds one end side and the other end side of the loop portion, and the wire member is one end of the loop portion that is held by the holding member by twisting the wire member. The intravascular foreign matter removing and aspiration catheter according to any one of claims 1 to 3, wherein the length between the side and the other end is changed, and the size of the loop portion can be changed. The operating portion is fixed to a wire-like member at a portion protruding from the rear end portion of the catheter tube, and is configured by an operating member capable of performing the forward and backward movements and the twisting of the wire-like member. The catheter for removing and sucking intravascular foreign matter according to claim 5. An intravascular foreign matter removal and suction catheter comprising a wire-like member having a loop portion for removing foreign matter in a blood vessel, and a catheter tube having a lumen inside and connectable with suction means for sucking the inside of the lumen. The surface of the loop portion is a surface having lubricity when wet, and the loop portion includes one end portion of the wire-like member fixed to the distal end portion of the catheter tube and the catheter. The body is formed between the main body parts accommodated in the tube, and the catheter is further sized by looping the wire-like member by feeding the main body part to the distal end side of the catheter and pulling back to the proximal end side. A catheter for removing and sucking intravascular foreign matter, comprising an operation unit for changing. The intravascular foreign matter removing and aspiration catheter according to claim 7, wherein the main body portion of the wire-like member is accommodated in the lumen of the catheter tube. The catheter for removing intravascular foreign matter according to claim 7, wherein the catheter tube includes a wire-shaped member housing lumen that houses the main body portion of the wire-shaped member. An intravascular foreign matter removal and suction catheter comprising a wire-like member having a loop portion for removing foreign matter in a blood vessel, and a catheter tube having a lumen inside and connectable with suction means for sucking the inside of the lumen. The wire-like member includes a plurality of portions having different flexibility, and includes two main body portions that are folded back at the loop portion and extend in parallel to the rear end side of the catheter tube. The catheter has a wire-like member portion constituting the loop portion by feeding the two main body portions of the wire-like member to the distal end side of one catheter and pulling back the main body portion to the proximal end side of the other catheter. And the wire-like member of the catheter tube in a state of protruding from the distal end of the catheter tube of the loop portion. Removing an intravascular foreign body aspiration catheter, characterized in that it comprises an operation unit for performing forward and backward in the axial direction. 11. The intravascular foreign body removal suction according to claim 10, wherein the surface of at least a portion of the wire-like member protruding from the distal end of the catheter tube and capable of forming a loop portion is a surface having lubricity when wet. catheter. The catheter is provided in the catheter tube at a position closer to the proximal end than the suction means connecting portion, and the catheter tube is substantially liquid-tightly closed, and the wire-like member is in a liquid-tight state. The intravascular foreign matter removing and aspiration catheter according to any one of claims 1 to 11, further comprising a slidable valve member.

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