JP2005263793A - Skin lotion - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin lotion having improved high-temperature stability. <P>SOLUTION: A skin lotion having excellent stability is produced by using a natural surfactant, glycol or glycerol, a liquid ester oil and a glycol ether as essential components. The efficient impregnation of the useful components to the skin is expectable because the transcutaneous absorption is improved by the proper selection of the dosage form. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to a skin external preparation having improved high-temperature stability.

There are various types of external preparations applied to the skin and mucous membranes, such as patches, ointments, creams, lotions, solid preparations, etc. These external preparations contain a surfactant. There are many things. Surfactants are roughly classified into synthetic compounds and those derived from nature, and nonionic surfactants of synthetic compounds are widely used as external emulsifiers as emulsifiers. Nonionic surfactants (synthetic) are said to have relatively low skin irritation, but may cause problems such as irritation due to large individual differences.
On the other hand, natural surfactants originate from those present in natural animals and plants, and most of them are safe and can be used in foods, and are expected to promote their use. However, there is a problem that a sufficient amount of oil cannot be blended because the emulsifying power is weak as compared with a synthetic surfactant, and a dispersion system that is essentially unstable cannot be kept stable for a long time. In particular, liquid crystals have poor stability at high temperatures, and microemulsions require a large amount of surfactant, so that they are difficult to prepare using a natural surfactant.
Non-aqueous gel cosmetics (Patent Document 1: Japanese Patent Laid-Open No. 5-4911), organogels (Patent Document 2: Japanese Patent Laid-Open No. 2001-114643) and the like are known as external preparations for skin containing a natural surfactant. However, it does not disclose a combination of high concentration of glycerin and a specific oil.
Furthermore, since an external preparation for skin is often used by directly applying to an application site, a preparation excellent not only in the stability of the preparation but also in functions such as ease of adapting to the skin is desired.

  An object of the present invention is to provide an external preparation for skin having improved high-temperature stability.

As a result of intensive studies to achieve the above object, the inventors of the present invention significantly improved high-temperature stability when a glycol ether is added to a composition containing a natural surfactant, glycol or glycerin, and oil. The present invention has been completed.
That is, this invention is a skin external preparation listed to following (1)-(9).
(1) A skin external preparation containing (A) a natural surfactant, (B) glycol or glycerin, (C) liquid ester oil, and (D) glycol ether.
(2) glycol ether is ethylene glycol monoether, ethylene glycol diether, propylene glycol monoether, propylene glycol diether, butylene glycol monoether, butylene glycol diether, diethylene glycol monoether, diethylene glycol monoether, diethylene glycol diether, di The skin external preparation according to (1), which is one or more selected from the group consisting of propylene glycol monoether, dipropylene glycol diether, dibutylene glycol monoether and dibutylene glycol diether.
(3) The external preparation for skin according to (1) or (2), wherein the natural surfactant is a phospholipid and a glycolipid.
(4) The liquid ester oil is a liquid monoalcohol monoester, liquid diol diester, liquid triol triester, liquid tetraol tetraester, or liquid pentaol pentaester having no free hydroxyl group in the molecule (1) to (3 ) External preparation for skin.
(5) The external preparation for skin according to (1) to (4), further containing a hydrocarbon or silicone.
(6) The external preparation for skin according to (1) to (5), further containing water.
(7) The skin external preparation according to any one of (1) to (6), wherein the skin external preparation is a liquid crystal type skin external preparation.
(8) The external preparation for skin according to (1) to (7), wherein the external preparation for skin is a microemulsion type external preparation for skin.
(9) The external preparation for skin according to (1) to (8), which contains substantially no synthetic surfactant.
The present invention also includes the following methods.
(10) A method for improving the stability of an external preparation for skin by blending glycol ether with an external preparation for skin containing (A) a natural surfactant, (B) glycol or glycerin, and (C) a liquid oil.

  This invention can keep a skin external preparation stable by containing a natural surfactant, glycol or glycerin, liquid ester oil, and glycol ether. Moreover, since transdermal absorbability can be improved depending on the dosage form, efficient penetration of useful components into the skin can be expected.

BEST MODE FOR CARRYING OUT THE INVENTION

  The external preparation for skin of the present invention comprises (A) a natural surfactant, (B) glycol or glycerin, (C) liquid ester oil, and (D) glycol ether.

The natural surfactant used in the present invention is not particularly limited as long as it is a substance having a surface-active effect mainly of animal or plant origin. Even if it is a natural product extracted and purified from animals and plants, these natural products are converted into cells. It may be chemically synthesized, genetically engineered, or chemically synthesized, and may be subjected to processing such as hydrogenation or hydroxylation. Commercial products may also be used.
In the present invention, the natural surfactant is not particularly limited as long as it is a substance having a surface-active effect mainly derived from animals or plants. Phospholipid, glycolipid, ceramide (sphingolipid), cholesterol, alkylpolyglycoside, Acylated collagen, glycyrrhizinate, caseinate, albumin, biotin, gluten, pectin, mucin, saponin, chondroitin sulfate, hyaluronate, deoxyribonucleic acid salt, elastin hydrolyzate, collagen hydrolyzate, N-acyl glutamate , Menthol, borneol, bile acid and the like, preferably phospholipid or glycolipid.

  Natural surfactants can also be used as pharmaceutically acceptable salts, for example, salts with organic bases (for example, trimethylamine salts, triethylamine salts, monoethanolamine salts, triethanolamine salts, pyridine salts, etc.). Salts with tertiary amines, basic ammonium salts such as arginine), salts with inorganic bases (for example, alkali metal salts such as ammonium, sodium and potassium salts, alkaline earth metals such as calcium and magnesium salts) Salt, aluminum salt and the like), and particularly preferable salts are sodium salt and potassium salt. Specific examples include sodium glycyrrhizinate, sodium caseinate, sodium chondroitin sulfate, sodium hyaluronate, sodium deoxyribonucleic acid, sodium N-acyl glutamate, sodium bile acid and the like.

Examples of natural surfactants in the present invention include phospholipids and glycolipids, and these are substances used as components such as cell membranes. Glycerophospholipids, glyceroglycolipids, sphingolipids, sphingolipids, sphingolines Lipids, glycosphingolipids, etc. exist. Any lipid that has a surface-active effect may be used.
Glycerophospholipid is a substance having a glycerophosphoric acid skeleton, and has a fatty acid ester, a long-chain alkyl ether, a vinyl ether or the like as a lipophilic group. Specific examples include phosphatidylcholine (lecithin), phosphatidylethanolamine, phosphatidylserine, phosphadiylinositol, phosphatidylinositol polyphosphate, diphosphatidylglycerol (cardiolipin), phosphatidic acid, and lysophospholipid, preferably lecithin. Lecithin is obtained by extraction and purification from soybean or egg yolk. The lecithin may be hydrogenated or hydroxylated, hydrogenated lecithin, hydroxylated lecithin or the like.
The glyceroglycolipid has a carbohydrate, choline phosphate, 2-aminoglycerol and the like as a hydrophilic group, and has diacylglycerol, dialkylglycerol, alkylacylglycerol, and alkenylacylglycerol as a lipophilic group.
Sphingolipids are long-chain bases or long-chain fatty acids such as sphingosine and phytosphingosine, and fatty acids in an amide bond, and include ceramide 1, ceramide 2, ceramide 3, ceramide 4, ceramide 5, ceramide 6 and the like. Ceramide 3 and ceramide 6 are preferable.
Sphingophospholipids have long-chain bases or long-chain fatty acids such as sphingosine and phytosphingosine, and phosphoric acid or phosphonic acid. Ceramide 1-phosphate derivatives (such as sphingomyelin), ceramide 1-phosphonic acid derivatives ( Ceramide aminoethylphosphonic acid and the like).
Glycosphingolipids have long-chain bases or long-chain fatty acids such as sphingosine and phytosphingosine and sugars, and include cerebroside, sulfatide, ceramide oligohexoside, globoside, ganglioside, sucrose fatty acid ester, etc. Is ceramide oligohexoside, sucrose fatty acid ester.
These natural surfactants can be used alone or in combination of two or more.

  The blending amount of the natural surfactant used in the present invention is not particularly limited as long as the effects of the present invention are exerted, but as a whole external preparation for skin, 0.001 to 10% by weight, preferably 0.01 to 5% by weight, particularly preferably 0.1. It should be ~ 5% by weight. If the amount is less than 0.001% by weight, it becomes difficult to formulate, and if it exceeds 10% by weight, the feeling of use tends to decrease, which is not preferable.

In the present invention, the glycol may be any polyhydric alcohol that is liquid at 30 ° C., specifically, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 2 1,3-butylene glycol, pentamethylene glycol, hexylene glycol, octylene glycol and the like, and propylene glycol and 1,3-butylene glycol are preferable.
Glycerin is a known compound that is frequently used in external preparations for skin.
These glycols or glycerin can be used alone or in combination of two or more.

  The blending amount of glycol or glycerin used in the present invention is not particularly limited as long as the effects of the present invention are exhibited, but as a whole skin external preparation, 1 to 85% by weight, preferably 5 to 85% by weight, particularly preferably 10 to 80% by weight is sufficient. If the amount is less than 1% by weight, preparation becomes difficult, and if it exceeds 85% by weight, the feeling of use tends to decrease.

  The liquid ester oil used in the present invention is not particularly limited as long as it has an ester bond and is liquid at 30 ° C. For example, monoalcohol monoester, diol monoester, diol diester, triol diester, triol triester, tetra Examples include all triesters, tetraol tetraesters, pentaol tetraesters, pentaol pentaesters, preferably monoalcohol monoesters, diol diesters, triol triesters, tetraol tetraesters having no free hydroxyl groups in the molecule. , Pentaol pentaester.

Monoalcohol monoesters include dl-α-tocopherol acetate, d-α-tocopherol acetate, acetic acid-β-tocopherol, acetic acid γ-tocopherol, acetic acid δ-tocopherol, C2 or more monoalcohol and C8 or more linear or branched. Esters with fatty acids are preferred, and C2 or higher alcohols include ethanol, propanol, isopropanol, butanol, isobutanol, pentanol, hexanol, octanol, 2-ethylhexanol, nonyl alcohol, isononyl alcohol, decyl alcohol, isodecyl alcohol , Tridecyl alcohol, isotridecyl alcohol, myristyl alcohol, cetanol, isocetanol, 2-hexyldecyl alcohol, stearyl alcohol, isostearyl alcohol , 2-heptylundecyl alcohol, 2-octyldodecyl alcohol, etc., and C8 or higher linear or branched fatty acids include caprylic acid, octanoic acid, 2-ethylhexanoic acid, nonanoic acid, isononanoic acid, capric acid, Examples include dimethyloctanoic acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, adipic acid, glutamic acid, and sebacic acid.
Specifically, cetyl octoate, isocetyl octoate, cetostearyl octoate, stearyl octoate, isostearyl octoate, cetyl 2-ethylhexanoate, hexyldecyl dimethyloctanoate, isopropyl myristate, isostearyl myristate, myristic Isocetyl acid, octyldodecyl myristate, myristyl myristate, 2-hexyldecyl myristate, isopropyl palmitate, isostearyl palmitate, 2-hexyldecyl palmitate, 2-heptyl undecyl palmitate, octyl palmitate, palmitic acid 2 -Ethylhexyl, ethyl stearate, butyl stearate, ethyl laurate, hexyl laurate, hexyl decyl dimethyloctanoate, isocetyl stearate, Isopropyl stearate, isocetyl isostearate, isostearyl isostearate, isononyl isononanoate, tridecyl isononanoate, isodecyl isononanoate, isotridecyl isononanoate, oleyl oleate, ethyl oleate, decyl oleate, octyldodecyl oleate, ethyl linoleate, Examples include isopropyl linoleate, 2-hexyldecyl adipate, diisobutyl adipate, di-2-heptylundecyl adipate, di-2-ethylhexyl sebacate, diisopropyl sebacate and the like.

The diol monoester is preferably an ester of glycol and a C8 or higher straight chain or branched fatty acid. Examples of the glycol include ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 2 , 3-butylene glycol, pentamethylene glycol, hexylene glycol, neopentylene glycol, octylene glycol, etc., and C8 or higher linear or branched fatty acids include caprylic acid, octanoic acid, 2-ethylhexanoic acid, Nonanoic acid, isononanoic acid, capric acid, dimethyloctanoic acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, adipic acid, glutamic acid, sebacic acid and the like.
Specific examples include propylene glycol monocaprylate.

The diol diester is preferably an ester of glycol and a C8 or higher linear or branched fatty acid. As the glycol, ethylene glycol, propylene glycol, trimethylene glycol, 1,2-butylene glycol, 1,3-butylene glycol, 2, Examples include 3-butylene glycol, pentamethylene glycol, hexylene glycol, neopentylene glycol, and octylene glycol. Examples of the C8 or higher linear or branched fatty acid include caprylic acid, octanoic acid, 2-ethylhexanoic acid, and nonane. Examples include acids, isononanoic acid, capric acid, dimethyloctanoic acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, adipic acid, glutamic acid, sebacic acid and the like.
Specifically, ethylene glycol di-2-ethylhexanoate, N-alkyl glycol monoisostearate, propylene glycol diisononanoate, di-2-ethylhexanoate neopentylene glycol, propylene glycol dicaprate, propylene glycol dicaprylate, Propylene glycol dinonanoate, propylene glycol di (capryl / capric acid), propylene glycol distearate, propylene glycol diisostearate, propylene glycol dioleate, ethylene glycol diisononanoate, neopentyl glycol dicaprate, neopentyl glycol dicaprate, etc. .

  The triol diester is preferably an ester of a C3 or higher triol and a C8 or higher linear or branched fatty acid, and the C3 or higher triol includes glycerin, trimethylolpropane, pyridoxine, etc., and a C8 or higher linear or branched fatty acid. As caprylic acid, octanoic acid, 2-ethylhexanoic acid, nonanoic acid, isononanoic acid, capric acid, dimethyloctanoic acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, adipic acid, glutamic acid And sebacic acid.

The triol triester is preferably an ester of a C3 or higher triol and a C8 or higher straight chain or branched fatty acid, and the C3 or higher triol includes glycerin, trimethylolpropane, pyridoxine, etc., and a C8 or higher straight chain or branched chain. As fatty acids, caprylic acid, octanoic acid, 2-ethylhexanoic acid, nonanoic acid, isononanoic acid, capric acid, dimethyloctanoic acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid, adipic acid, Examples thereof include glutamic acid and sebacic acid.
Specifically, tri-2-ethylhexanoic acid trimethylolpropane, triisostearic acid trimethylolpropane, tri-2-ethylhexanoic acid glyceryl, trioctanoic acid glyceryl, tripalmitic acid glycerin, triisopalmitic acid glycerin, trimyristic acid glycerin Glyceryl triisostearate, glyceryl trioleate, glyceryl tricaprylate, glyceryl tri (capryl / capric acid), glyceryl tri-2-heptylundecanoate, pyridoxine tri-2-hexyldecanoate, pyridoxine tricaprylate, pyridoxine tripalmitate, etc. Can be mentioned.

The tetraol triester is preferably an ester of C4 or higher and a linear or branched fatty acid of C8 or higher. Examples of the C4 or higher tetraol include pentaerythritol, ascorbic acid, diglyceryl, etc. As linear or branched fatty acids, caprylic acid, octanoic acid, 2-ethylhexanoic acid, nonanoic acid, isononanoic acid, capric acid, dimethyloctanoic acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, linoleic acid , Adipic acid, glutamic acid, sebacic acid and the like.
Specific examples include diglyceryl triisostearate.

The tetraol tetraester is preferably an ester of a C4 or higher tetraol and a C8 or higher linear or branched fatty acid, and the C4 or higher tetraol includes pentaerythritol, ascorbic acid, diglyceryl, polyglyceryl, etc. As the above linear or branched fatty acids, caprylic acid, octanoic acid, 2-ethylhexanoic acid, nonanoic acid, isononanoic acid, capric acid, dimethyloctanoic acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, Linoleic acid, adipic acid, glutamic acid, sebacic acid and the like can be mentioned.
Specific examples include pentaerythritol tetra-2-ethylhexanoate, polyglyceryl tetraisostearate, ascorbyl tetra-2-hexyldecanoate, and the like.

  These liquid ester oils can be used alone or in any combination of two or more. Furthermore, it is particularly preferable to use a combination of liquid ester oils having different alcohol valences (for example, monoalcohol monoester and diol diester) because the stability becomes higher.

  The blending amount of the liquid ester oil used in the present invention is not particularly limited as long as the effects of the present invention are obtained, but is generally 0.01 to 80%, preferably 0.1 to 60% by weight, particularly preferably 1 to 50% as a whole skin external preparation. It is sufficient if it is weight%. If it is less than 0.01% by weight, it is difficult to formulate or a sufficient effect cannot be obtained, and if it exceeds 80% by weight, the stability tends to decrease, which is not preferable.

  In the present invention, the glycol ether is not particularly limited as long as one or both of the hydroxyl groups of glycol are etherified. The glycol may be a single oligomer, a polymer, or two or more oligomers. good. For example, ethylene glycol monoether, ethylene glycol diether, diethylene glycol monoether, diethylene glycol diether, triethylene glycol monoether, triethylene glycol diether, tetraethylene glycol monoether, tetraethylene glycol diether, polyethylene glycol monoether, propylene Glycol monoether, propylene glycol diether, dipropylene glycol monoether, dipropylene glycol diether, tripropylene glycol monoether, tripropylene glycol diether, polypropylene glycol monoether, butylene glycol monoether, butylene glycol diether, alkylene glycol Such as acetate That. Examples of ethers include alkyl ethers, alkoxy ethers, aromatic ethers, and allyl ethers. Specifically, ethyl ether, methyl ether, n-propyl ether, isopropyl ether, n-butyl ether, isobutyl ether, t-butyl ether. N-pentyl ether, n-hexyl ether, phenyl ether, vinyl ether and the like.

  Specific examples of glycol ethers include ethylene glycol monovinyl ether, ethylene glycol monoethyl ether, ethylene glycol mono-n-propyl ether, ethylene glycol monoisopropyl ether, ethylene glycol mono-n-butyl ether, ethylene glycol monoisobutyl ether, ethylene glycol Mono-t-butyl ether, ethylene glycol mono-2-methylpentyl ether, ethylene glycol mono-n-hexyl ether, ethylene glycol mono-24-hexadiene ether, ethylene glycol mono-2,6,8-trimethyl-4-nonyl ether Ethylene glycol monoethers such as ethylene glycol monophenyl ether and ethylene glycol monomethyl phenyl ether; And ethylene glycol diethers such as ethylene glycol diethyl ether; diethylene glycol monomethyl ether, diethylene glycol monoethyl ether (hereinafter also referred to as ethoxy diglycol), diethylene glycol mono-n-propyl ether, diethylene glycol mono-n-butyl ether, diethylene glycol monoisobutyl ether Diethylene glycol monoethers such as diethylene glycol mono-n-hexyl ether and diethylene glycol monomethyl phenyl ether; diethylene glycol diethers such as diethylene glycol dimethyl ether and diethylene glycol divinyl ether; triethylene glycol monomethyl ether, triethylene glycol monoethyl ether, triethylene glycol Triethylene glycol monoethers such as mono-n-butyl ether and triethylene glycol monovinyl ethyl ether; Triethylene glycol diethers such as triethylene glycol dimethyl ether and triethylene glycol divinyl ether; Tetraethylene glycol mono ethers such as tetraethylene glycol monophenyl ether Ether; Tetraethylene glycol diether such as tetraethylene glycol diethyl ether; Polyethylene glycol monoether such as polyethylene glycol monomethyl ether; Propylene glycol monomethyl ether, Propylene glycol monoethyl ether, Propylene glycol-n-monopropyl ether, Propylene glycol monoisopropyl Ether, propylene glycol Propylene glycol monoethers such as mono-n-butyl ether, propylene glycol monoisobutyl ether, propylene glycol monoallyl ether, propylene glycol monophenyl ether; propylene glycol dimethyl ether, propylene glycol diethyl ether, propylene glycol-n-dipropyl ether, propylene glycol Propylene glycol diethers such as diisopropyl ether, propylene glycol di n-butyl ether, propylene glycol diisobutyl ether, propylene glycol diallyl ether, propylene glycol diphenyl ether; dipropylene glycol monoethyl ether, and dipropylene glycol mono-n-butyl ether, dipropylene glycol Monoisobutyl Dipropylene glycol monoethers such as ether, dipropylene glycol allyl ether; dipropylene glycol diethers such as dipropylene glycol diethyl ether, dipropylene glycol di n-butyl ether, dipropylene glycol diisobutyl ether, dipropylene glycol allyl ether; Propylene glycol monomethyl ether, tripropylene glycol monoethyl ether, and tripropylene glycol mono-ether such as tripropylene glycol mono-n-butyl ether, tripropylene glycol monoisobutyl ether, tripropylene glycol monoallyl ether; tripropylene glycol dimethyl ether, tripropylene Glycol diethyl ether and tripropylene glycol Tripropylene glycol diethers such as polypropylene n-butyl ether, tripropylene glycol diisobutyl ether, tripropylene glycol diallyl ether; polypropylene glycol monoethers such as polypropylene glycol monobutyl ether; butylene glycol monomethyl ether, butylene glycol monoethyl ether, and butylene glycol mono -Butylene glycol monoethers such as n-butyl ether; butylene glycol diethers such as butylene glycol dimethyl ether, butylene glycol diethyl ether, and butylene glycol di n-butyl ether; ethylene glycol monomethyl ether acetate, ethylene glycol monoethyl ether acetate, ethylene Glycol mono-n-butyl ether And alkylene glycol acetates such as acetate, diethylene glycol monoethyl ether acetate, diethylene glycol mono-n-butyl ether acetate, and propylene glycol monomethyl ether acetate.

  Preferred glycol ethers are ethylene glycol monoether, ethylene glycol diether, diethylene glycol monoether, diethylene glycol diether, triethylene glycol monoether, tetraethylene glycol monoether, tetraethylene glycol diether, polyethylene glycol monoether, propylene glycol mono Ether, propylene glycol diether, dipropylene glycol monoether, dipropylene glycol diether, tripropylene glycol monoether, specifically ethylene glycol monovinyl ether, ethylene glycol monoethyl ether, ethylene glycol mono-n-propyl ether , Ethylene glycol monoisopropyl ether, ethyl Glycol mono-n-butyl ether, ethylene glycol monoisobutyl ether, ethylene glycol mono-t-butyl ether, ethylene glycol mono-2-methylpentyl ether, ethylene glycol dimethyl ether, ethylene glycol diethyl ether, diethylene glycol monomethyl ether, diethylene glycol monoethyl ether, Diethylene glycol mono-n-propyl ether, diethylene glycol mono-n-butyl ether, diethylene glycol monoisobutyl ether, diethylene glycol mono-n-hexyl ether, diethylene glycol monomethyl phenyl ether, diethylene glycol dimethyl ether, diethylene glycol divinyl ether, diethylene glycol ethyl vinyl ether, triethyl Glycol monomethyl ether, triethylene glycol monoethyl ether, triethylene glycol mono-n-butyl ether, triethylene glycol monovinyl ethyl ether, tetraethylene glycol monophenyl ether, tetraethylene glycol diethyl ether, polyethylene glycol methyl mono ether, propylene glycol monomethyl Ether, propylene glycol monoethyl ether, propylene glycol-n-monopropyl ether, propylene glycol monoisopropyl ether, propylene glycol mono-n-butyl ether, propylene glycol phenyl ether, propylene glycol monomethyl ether, propylene glycol dimethyl ether, propylene glycol diethyl ether, Professional Pyrene glycol-n-dipropyl ether, propylene glycol diisopropyl ether, propylene glycol di n-butyl ether, propylene glycol diisobutyl ether, propylene glycol diallyl ether, propylene glycol diphenyl ether, dipropylene glycol monoethyl ether, dipropylene glycol mono-n-butyl ether , Dipropylene glycol diethyl ether, and dipropylene glycol di n-butyl ether, dipropylene glycol diisobutyl ether, dipropylene glycol allyl ether, tripropylene glycol monomethyl ether, tripropylene glycol monoethyl ether, and tripropylene glycol mono-n-butyl ether It is.

  More preferably, the glycol ether is ethylene glycol monoether, propylene glycol monoether, dipropylene glycol monoether, specifically ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol monopropyl ether, diethylene glycol monomethyl ether, Diethylene glycol monoethyl ether, diethylene glycol monopropyl ether, propylene glycol monoethyl ether, propylene glycol monopropyl ether, dipropylene glycol monoethyl ether, dipropylene glycol monopropyl ether.

  The blending amount of the glycol ether used in the present invention is not particularly limited as long as the effects of the present invention are exhibited, and can be appropriately selected and used in consideration of the feeling of use and effects on the skin. Usually, 1 to 60% by weight, more preferably 3 to 50% by weight, still more preferably 5 to 40% by weight, and particularly preferably 5 to 30% by weight.

In the external preparation for skin of the present invention, it is more preferable to further contain a hydrocarbon or silicone, since the stability becomes high. More preferably, these hydrocarbons or silicones are liquid at 30 ° C.
Liquid hydrocarbons include squalane, vegetable squalane, squalene, liquid paraffin, liquid isoparaffin, light liquid paraffin, light isoparaffin, light liquid isoparaffin, α-olefin oligomer, preferably squalane, vegetable squalane, liquid paraffin, light fluid. Paraffin etc. are mentioned.
Liquid silicones include diphenylpolysiloxane, methylpolysiloxane, dimethylpolysiloxane, alkyl-modified dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, trimethylsiloxysilicic acid, methylcyclopolysiloxane, stearoxymethylpolysiloxane, Examples thereof include cetoxymethyl polysiloxane, cetyl dimethicone, cetyl dimethicone copolyol, lauryl methicone copolyol, stearyl dimethicone copolyol, and the like, preferably silicone having no free hydroxyl group, specifically diphenylpolysiloxane, dimethylpolysiloxane. Siloxane, alkyl-modified dimethylpolysiloxane, methylphenylpolysiloxane, and methylpolysiloxane.

  The blending amount of the hydrocarbon or silicone used in the present invention is not particularly limited as long as the effects of the present invention are exhibited, but is generally 0.1 to 20% by weight, preferably 1 to 15% by weight, particularly preferably as a whole skin external preparation. May be 3 to 10% by weight. If the amount is less than 1% by weight, the stabilizing effect decreases, and if it exceeds 20% by weight, the stabilizing effect does not increase, which is not preferable.

  The method for preparing the external preparation for skin of the present invention is not particularly limited, and can be prepared by a conventional method by appropriately selecting and blending various components necessary for preparing an ordinary external preparation for skin. Moreover, the application amount and usage of the external preparation for skin of the present invention to the outer skin are not particularly limited, and it can be used usually by applying an appropriate amount to the outer skin such as skin several times a day.

  The external preparation for skin of the present invention can be prepared in various forms. For example, ointments, creams, liquids (including oils, lotions, emulsions, aerosols), gels (including liquid crystals and microemulsions), patches (including packs), solids (sticks) And the like, and is particularly useful when applied to liquid agents (including lotions, oils, and emulsions) and gel agents (including liquid crystals and microemulsions). Among these, liquid crystal and microemulsion are particularly preferable as an embodiment of the present invention because of the effect of stabilizing the preparation at high temperature.

A liquid crystal is a liquid with a high degree of crystallinity, generally having a long orientation in the constituent molecules, a fluidity and viscosity that is intermediate between solid and liquid, and exhibits optical anisotropy. There are many. The liquid crystal forms a hexagonal layer and a lamellar layer, and this structure causes refraction and reflection due to colored stripes and polarized light in white light, so it is easy to identify birefringence under the microscope and visual observation of liquid crystal formation. can do.
Since liquid crystals are similar in structure to biological bilayer membranes and intercellular lipids, they have the advantage that they are easy to adapt to the skin and can promote percutaneous absorption of useful components.

A microemulsion is generally defined as a transparent or translucent one-liquid phase consisting of an oil-water-amphiphile, and a system in which large swollen micelles are dispersed. It is said that. The average particle size of the microemulsion is preferably 0.5 μm or less from the viewpoint of optical transparency.
Microemulsions have the advantage that the formulation is more easily absorbed into the skin from the stratum corneum than normal emulsions because the micelles dispersed are small enough to have optical transparency.

  When the skin external preparation of the present invention is a liquid crystal type skin external preparation, a natural surfactant, a water-soluble compound, a small amount of water, etc. are added to and stirred in a mixed solution of glycerin or glycol and glycol ether, and the oil and oil-soluble compound Or the like can be appropriately added and stirred. Moreover, although the liquid crystal type skin external preparation of this invention can mix | blend a small amount of water, it can prepare also as a substantially anhydrous formulation, without mix | blending water separately.

  When the skin external preparation of the present invention is a microemulsion type skin external preparation, a natural surfactant or the like is added to and stirred in a mixed solution of glycerin or glycol and glycol ether, and an oil and an oil-soluble compound are appropriately added and stirred. Thereafter, a water-soluble compound and water can be added and emulsified and prepared using a high-pressure homomixer.

  The skin external preparation of the present invention may further contain water, and the amount of water is not particularly limited as long as the effect of the present invention is exerted, but is generally 0.001 to 97% by weight, preferably 0, as the whole skin external preparation. It may be 0.01 to 95% by weight, particularly preferably 0.1 to 90% by weight.

  Furthermore, the external preparation for skin of the present invention can be prepared as a preparation substantially containing no surfactant other than the natural surfactant without separately adding a surfactant other than the natural surfactant.

  Since the external preparation for skin of the present invention may belong to any category of pharmaceuticals, quasi-drugs, and cosmetics, it can be used for various applications. Examples of the use of the external preparation for skin of the present invention include eczema, rash, dry pruritus, xerosis, moisturized skin, bruise and other dermatitis therapeutic agents or antipruritics, cuts, scratches, etc. Infectivity to treat antiseptics, wound healing agents, athlete's foot, acne, etc. to promote and prevent deterioration of shoes, scratches, scratches, scissors, burns, purulent wounds, wrinkles, cracks, scratches, etc. Treatment for skin diseases or antibacterial agents, cheilitis, keratitis, lip cracks, sores, etc. Treatment for lips, finger contact, keratosis such as elbows, knees, heels, and ankles, shark skin Drugs such as keratin softeners and anti-inflammatory analgesics to treat, rough hands, rough skin, rough lips, hot flashes after sunburn, wrinkles / sag, smooth skin, smooth lips, keep skin / lips smooth, Gives moisture to skin and lips, skin Examples of suitable applications include quasi-drugs used to protect skin, prevent dryness, frostiness, cracks, red spots, rashes, etc., odor control, etc., and cosmetics used for moisturizing, whitening, keratin softening, cleansing, etc. However, it is not particularly limited to these.

The skin external preparation of the present invention can be combined with various components (including pharmacologically active components and physiologically active components) as necessary. The type of such ingredients is not particularly limited, and examples thereof include steroids, local anesthetics, antipruritics, anti-inflammatory agents, vitamins, antibacterial agents, antiviral agents, keratin softeners, analgesics, moisturizers, and whitening agents. Astringents, antioxidants, hair growth inhibitors, anti-wrinkle agents, and the like, and oil-soluble components are more preferred.
Examples of suitable components in the present invention include the following components.

  Steroid agents: Dexamethasone acetate dexamethasone, dexamethasone acetate, prednisolone acetate valerate, hydrocortisone butyrate, prednisolone acetate, prednisolone acetate, hydrocortisone acetate, hydrocortisone, cortisone acetate, betamethasone, clobetasone butyrate, triamcinolone acetonide, etc.

  Local anesthetics: lidocaine, lidocaine hydrochloride, dibucaine, dibucaine hydrochloride, ethyl aminobenzoate, eucalyptus oil, eugenol, menthol, camphor, mint oil, etc.

  Antipruritics: crotamiton, chlorpheniramine, chlorpheniramine maleate, diphenhydramine, nonylic acid vanillylamide, salicylic acid, methyl salicylate, glycolic salicylate, capsaicin, diphenhydramine hydrochloride, camphor, thymol, menthol, eugenol, hinokitiol, polyoxyethylene lauryl ether, Comfrey extract, perilla extract, sage extract, button pi extract, bodaiju extract, etc.

  Anti-inflammatory agents: Allantoin or derivatives thereof, salicylic acid derivatives such as indomethacin, ibuprofen, ibuprofen piconol, bufexamac, flufenamic acid butyl, bendazac, piroxicam, ketoprofen, felbinac, methyl salicylate or glycol salicylate.

  Vitamin preparations: Retinol derivatives such as retinol and retinol acetate (vitamins A), retinal, retinoic acid, methyl retinoic acid, ethyl retinoic acid, retinoic acid retinol, vitamin A oil, vitamin A fatty acid ester, etc., β- Provitamin A such as carotene, α-carotene, γ-carotene, δ-carotene, lycopene, zeaxanthin, cryptoxanthine, echinenone, vitamin E such as dl-α-tocopherol succinate, dl-α-tocopherol calcium succinate , Such as riboflavin, flavin mononucleotide, flavin adenine dinucleotide, riboflavin butyrate, riboflavin tetrabutyrate, sodium riboflavin 5'-phosphate, riboflavin tetranicotinate B2, nicotinic acids such as methyl nicotinate, ascorbic acid stearate, vitamin C such as L-ascorbyl dipalmitate, vitamin Ds such as methyl hesperidin, ergocalciferol, cholecalciferol, phylloquinone, farnoquinone, etc. Vitamin Ks, γ-oryzanol, dibenzoyl thiamine, dibenzoyl thiamine hydrochloride, thiamine hydrochloride, thiamine cetyl hydrochloride, thiamine thiocyanate, thiamine lauryl hydrochloride, thiamine nitrate, thiamine monophosphate, thiamine lysine salt, thiamine Triphosphate, thiamine monophosphate, thiamine monophosphate, thiamine diphosphate, thiamine diphosphate hydrochloride, thiamine triphosphate, thiamine triphosphate Vitamin B1 such as monophosphate, vitamin B6 such as pyridoxine hydrochloride, pyridoxine acetate, pyridoxal hydrochloride, 5'-phosphate pyridoxal, pyridoxamine hydrochloride, vitamin B12 such as cyanocobalamin, hydroxocobalamin, deoxyadenosylcobalamin, folic acid, Folates such as pteroylglutamic acid, nicotinic acids such as nicotinic acid and nicotinamide, pantothenic acid, calcium pantothenate, pantothenyl alcohol (panthenol), D-panthecin, D-panthetin, coenzyme A, pantothenylethyl Pantothenic acids such as ether, biotins such as biotin and biotin, ascorbic acid, sodium ascorbate, dehydroascorbic acid, sodium ascorbate phosphate ester, ascorbate phosphate ester Vitamin C is ascorbic acid derivatives such as Le magnesium, other, carnitine, ferulic acid, alpha-lipoic acid, and vitamin-like agents such as orotic acid.

Antibacterial agents: isopropylmethylphenol, chlorhexidine gluconate, chlorhexidine hydrochloride, benzalkonium chloride, benzethonium chloride, cetyltrimethylammonium bromide, decalinium chloride, triclosan, trichlorocarbanilide and the like.
Antiviral agents: acyclovir, penciclovir, etc.

  Keratin softener: ethyl alcohol, isopropyl alcohol, propanol, butanol, polyethylene glycol, benzyl alcohol, phenylethyl alcohol, propylene carbonate, hexyl decanol, allantoin, dimethyl sulfoxide, dimethylacetamide, dimethylformamide, triethanolamine, diisopropyl adipate, ethyl Laurylate, lanolin, fatty acid dialkyrolamide, salicylic acid, salicylic acid derivative, urea, sulfur, resorcin, glycolic acid, phytic acid, lactic acid, lactate, sodium hydroxide, potassium hydroxide and the like.

  Painkillers: mefenamic acid, flufenamic acid, indomethacin, methyl salicylate, glycol salicylate, diclofenac, diclofenac sodium, felbinac, alclofenac, bufexamac, aspirin, acetaminophen, ibuprofen, ketoprofen, pranoprofen, fenoprofen, fenglofen, Flurbiprofen, zaltoprofen, naproxen, flurbiprofen, flurbiprofen axetil, fenbufen, ricipfen, piroxicam, ampiroxicam, tenoxicam, oxyphenbutazone, phenylbutazone, clofesone, sulindac, clindac, benzaduck, L -Menthol, camphor, sulpyrine, thiaramide hydrochloride, orsenone, fenthiazac, benta Shin, such as Mepirizoru.

  Moisturizer: polyethylene glycol, diglycerin trehalose, sodium hyaluronate, heparin analog, chondroitin sulfate sodium, collagen, elastin, keratin, chitin, chitosan and other high molecular compounds, glycine, aspartic acid, arginine and other amino acids, sodium lactate, Natural moisturizing factors such as urea and sodium pyrrolidonecarboxylate, plant extract extracts such as chamomile extract, aloe extract, aloe vera extract, hamamelis extract, rosemary extract, thyme extract, tea extract and perilla extract.

  Whitening agents: vitamins A or derivatives thereof, vitamins C or derivatives thereof, vitamins E or derivatives thereof, vitamins such as pantothenic acid or derivatives thereof, placenta; arbutin; kojic acid; cysteine; phytic acid; iris (iris), almond, Aloe, Ginkgo, Oolong tea, Ages, Ogon, Ouren, Hypericum, Olysam, Seaweed, Cascon, Licorice, Gardenia, Kujin, Wheat, Rice, Rice haiga, Oryzanol, Rice bran, Perilla, Peonies, Senkyu, Sakuhachi, Saki, Tea, Soy Ingredients, extracts and essential oils derived from plants such as eucalyptus, hamamelis, safflower, button pi, yokuinin, touki, enoki, oyster (Diospyros kaki), clove.

Astringent: citric acid, tartaric acid, lactic acid, aluminum chloride, aluminum sulfate, allantoinchlorohydroxyaluminum, allantoindihydroxyaluminum, aluminum phenolsulfonic acid, zinc paraphenolsulfonic acid, zinc sulfate, zinc lactate, aluminum chlorohydroxide and the like.
Antioxidants: dibutylhydroxytoluene, butylhydroxyanisole, ascorbic acid, erythorbic acid, dl-α-tocopherol, disodium ethylenediaminetetraacetate dihydrate (hereinafter also referred to as sodium edetate), sorbic acid, sodium sulfite, L-cysteine hydrochloride and the like.

Hair growth inhibitor: isoflavone, cypress extract, docami extract, iris root extract, papain enzyme, etc.
Anti-wrinkle agent: Vitamin A and its derivatives, glycolic acid, acylated glucosamine, kinetin, vitamin C, vitamin E, aloe, collagen, hyaluronic acid, tripeptide, seaweed extract, maronier extract, rosemary extract, cornflower extract and the like.

  These components can be used alone or in combination of two or more. Moreover, those compounding amounts are not particularly limited as long as the effects of the present invention are obtained, but can be suitably selected and used as long as the upper limit compounding amount allowed by the Pharmaceutical Affairs Law is desirable. Specifically, it is prepared according to the purpose from the range of usually 0.001 to 20 parts by weight, preferably 0.001 to 10 parts by weight, more preferably 0.001 to 5 parts by weight per 100 parts by weight of the external preparation for skin. be able to.

  The external preparation for skin of the present invention does not impair quality such as storage stability and viscosity, and within the quantitative and qualitative range that does not impair the effects of the present invention, as necessary, in the pharmaceutical, quasi-drug or cosmetic field. Ingredients commonly used in the formulation, such as bases, surfactants, thickeners, preservatives, pH adjusters, stabilizers, irritation reducers, preservatives, colorants, dispersants, fragrances, etc. can do. In addition, these components can be mix | blended individually by 1 type or in combination of 2 or more types.

  Base: hydrocarbons such as paraffin, gelled hydrocarbon, ozokerite, ceresin, petrolatum, hard fat, microcrystalline wax, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, isostearic acid, oleic acid, linoleic acid Fatty acids such as, highly polymerized methylpolysiloxane, dimethylsiloxane methyl (polyoxyethylene) siloxane methyl (polyoxypropylene) siloxane copolymer, dimethylsiloxane methyl (polyoxyethylene) siloxane copolymer, dimethylsiloxane methyl (Polyoxypropylene) siloxane copolymer, polyoxyethylene / methylpolysiloxane copolymer, poly (oxyethylene / oxypropylene) / methylpolysiloxane copolymer, dimethylsiloxane / methyl Cetyloxysiloxane copolymer, dimethylsiloxane / methylstearoxysiloxane copolymer, alkyl acrylate copolymer methylpolysiloxane ester, crosslinked methylpolysiloxane, crosslinked methylphenylpolysiloxane, crosslinked polyether-modified silicone, crosslinked Type alkyl polyether-modified silicone, polymerization type silicone such as cross-linked alkyl-modified silicone, ethylene glycol monoacetate, ethylene glycol diacetate, triethylene glycol diacetate, hexylene glycol diacetate, and 2-methyl-2 -Glycol acetates such as propene-1,1-diol diacetate, triethylene glycol divalerate, 2,2,4-trimethyl-1,3-pentanediol monoisobutyrate, 2,2,4-trimethyl 1,3-pentanediol Glycol esters such as diisobutyrate, ethylene glycol diacrylate, diethylene glycol diacrylate, propylene glycol monoacrylate, 2,2-dimethyl-trimethylene glycol diacrylate, and 1,3-butylene glycol diacrylate Glycol dinitrates such as glycol acrylate, ethylene glycol dinitrate, diethylene glycol dinitrate, triethylene glycol dinitrate, and propylene glycol dinitrate, 2,2 '-[1,4-phenylenedioxy] diethanol, dioxane, butylene glycol Adipic acid polyester and so on.

  Surfactants: Sorbitan fatty acid esters such as sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, diglycerol sorbitan penta-2-ethylhexylate, diglycerol sorbitan tetra-2-ethylhexylate Glyceryl fatty acids such as glyceryl monostearate and glyceryl monostearate malic acid, polyglyceryl fatty acids such as polyglyceryl monoisostearate and polyglyceryl diisostearate, propylene glycol fatty acid esters such as propylene glycol monostearate, polyoxyethylene cured Hardened castor oil derivatives such as castor oil 40, polyoxyethylene hydrogenated castor oil 60, polyoxyethylene hydrogenated castor oil 80, monolauri Polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene (20) sorbitan (polysorbate 20), polyoxyethylene (20) sorbitan monostearate (polysorbate 60), polyoxyethylene (20) sorbitan monooleate (polysorbate 80) , Polyoxyethylene monococonut oil fatty acid glyceryl, glycerin alkyl ether, alkyl glucoside, polyoxyethylene cetyl ether and the like.

  Thickener: Guar gum, locust bean gum, carrageenan, xanthan gum, dextran, methylcellulose, ethylcellulose, carboxymethylcellulose, hydroxyethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, sodium alginate, propylene glycol alginate, polyvinyl alcohol, polyvinylpyrrolidone , Polyvinyl methyl ether, carboxyvinyl polymer, alkyl methacrylate copolymer, sodium polyacrylate, polyethylene glycol, bentonite, dextrin fatty acid ester, pectin and the like.

  Preservatives: Benzoic acid, sodium benzoate, dehydroacetic acid, sodium dehydroacetate, isobutyl paraoxybenzoate, isopropyl paraoxybenzoate, butyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate, benzyl paraoxybenzoate, paraoxybenzoic acid Methyl, phenoxyethanol, etc.

  pH adjusters: inorganic acids (hydrochloric acid, sulfuric acid, phosphoric acid, polyphosphoric acid, boric acid, etc.), organic acids (lactic acid, acetic acid, citric acid, tartaric acid, malic acid, succinic acid, sodium succinate, oxalic acid, gluconic acid, Fumaric acid, propionic acid, acetic acid, aspartic acid, epsilon-aminocaproic acid, glutamic acid, aminoethylsulfonic acid, etc.), gluconolactone, ammonium acetate, inorganic base (sodium bicarbonate, sodium carbonate, potassium hydroxide, sodium hydroxide, Calcium hydroxide, magnesium hydroxide, etc.), organic bases (monoethanolamine, triethanolamine, diisopropanolamine, triisopropanolamine, lysine, etc.).

These components can be used alone or in combination of two or more. Moreover, those compounding amounts are not particularly limited as long as the effects of the present invention are obtained, but can be suitably selected and used as long as the upper limit compounding amount allowed by the Pharmaceutical Affairs Law is desirable. Specifically, the amount is usually 0.001 to 20 parts by weight, preferably 0.
It can be prepared according to the purpose from the range of 001 to 10 parts by weight, more preferably 0.001 to 5 parts by weight.

Furthermore, this invention also includes the method of improving the stability of a skin external preparation. In the method of the present invention, stabilization of a skin external preparation containing a natural surfactant, glycol or glycerin, and liquid oil can be achieved by blending with glycol ether.
In the method of the present invention, the natural surfactant, glycol, glycerin, glycol ether, and the blending amount and blending ratio thereof are the same as those used in the external preparation for skin.
In the method of the present invention, the liquid oil is not particularly limited as long as it is liquid at 30 ° C., and examples thereof include liquid ester oil, liquid hydrocarbon, and liquid silicon. About liquid ester oil, liquid hydrocarbon, liquid silicon, and these compounding quantity and compounding ratio, it is the same as that used with the said skin external preparation.
The composition obtained by using this method can be used in a dosage or administration by a known or commonly used method, divided into 1 to several times per day according to the formulation form. it can.

  EXAMPLES The present invention will be specifically described below with reference to examples, but these examples do not limit the scope of the present invention. In addition, a compounding quantity etc. represent weight% altogether about purified water or a thing without the description of a unit.

Test example Preparation stability According to the formulations shown in Tables 1 and 2, for the preparation prepared by adding lecithin into a mixed solution of glycerin and ethoxydiglycol and thoroughly stirring, and then adding oil, the phase state and humidity immediately after preparation Appearance change after 1 month storage in a constant temperature room of 75% and 40 ° C. was evaluated.
The results are shown in Tables 1 and 2.

  From Comparative Examples 1 to 3, it was found that both the preparations could not be kept stable without ethoxydiglycol. On the other hand, it was confirmed that Examples 1-4 were all highly stable.

  In Examples 5 to 11, it is shown that any liquid crystal, emulsified, and uniformly transparent preparation has good high-temperature stability. Further, in Example 7, the liquid crystal was retained even when the amount of liquid ester oil to be blended was as high as 35% by weight of the whole preparation, indicating the high usefulness of the present invention. Further, Example 10 forms a microemulsion, and the high temperature stability can be maintained with a high liquid ester oil content.

  Examples 1 to 10 in Tables 1 and 2 are stable at high temperatures while forming liquid crystals or microemulsions, so that these preparations are inherently compatible with the skin and promote percutaneous absorption. From the functions, it is possible to expect efficient penetration of the useful components into the skin by adding the oil-soluble useful components to the above examples. Among them, ascorbyl tetra-2-hexyldecanoate blended in the above examples is one of the oil-soluble useful components known to change into active ascorbic acid in vivo. Even if it is used as it is, it is particularly useful because a pharmacological effect can be sufficiently expected.

  The formulation examples are given below. In addition, the compounding quantity in a following example represents weight% altogether about purified water or the thing without the description of a unit especially.

Example 12 White water-soluble gel Hydrogenated soybean lecithin 0.5
Dipotassium glycyrrhizinate 0.1
Glycerin 10.0
Ethoxydiglycol 7.0
Propylene glycol dicaprate 1.0
Cetyl 2-ethylhexanoate 1.0
Methylphenylpolysiloxane 3.0
Squalane 1.0
Tocopherol acetate 0.5
Allantoin 0.1
Polyoxyethylene hydrogenated castor oil 60 0.5
Hydroxyethyl cellulose 0.2
Acrylic acid / alkyl methacrylate copolymer 0.4
Triethanolamine 0.25
Sodium edetate 0.05
Purified water remaining
100%

Example 13 Transparent water-soluble gel egg yolk lecithin 0.2
Glycerin 15.0
Ethoxydiglycol 8.0
Propylene glycol dicaprylate 0.1
Aloe vera extract 1.0
Chamomile extract 0.5
Absolute ethanol 8.0
Polyoxyethylene hydrogenated castor oil 40 4.0
Triethanolamine 0.75
Carboxyvinyl polymer 0.5
Xanthan gum 0.5
Sodium alginate 0.3
Sodium edetate 0.05
Purified water remaining
100%

Example 14 Lotion Sodium Hyaluronate 0.02
Glycerin 20.0
1,3-butylene glycol 5.0
Ethoxydiglycol 5.0
Trimethylolpropane tri-2-ethylhexanoate 0.01
Polyoxyethylene hydrogenated castor oil 80 0.6
Polyethylene glycol 1500 0.5
Succinic acid 0.4
Collagen hydrolyzate 0.1
Sodium succinate 0.06
Purified water remaining
100%

Example 15 Cleansing Hydrogenated Lecithin 0.5
Tetra-2-ethylhexanoic acid pentaerythritol 5.0
Tri (capryl / capric acid) glyceryl 5.0
Glycerin 20.0
Ethoxydiglycol 9.0
Light liquid paraffin 10.0
Alkyl glucoside 10.0
Polyoxyethylene hydrogenated castor oil 40 1.0
Polyoxyethylene monococonut oil fatty acid glyceryl 1.0
Carboxyvinyl polymer 0.5
Triethanolamine 0.1
Purified water remaining
100%

Example 16 Cream Soy Lecithin 0.1
Dipropylene glycol 5.0
Ethoxydiglycol 15.0
Trimethylolpropane triisostearate 0.5
Glyceryl tri-2-ethylhexanoate 5.0
White petrolatum 10.0
Polyoxyethylene hydrogenated castor oil 40 1.9
Stearyl alcohol 1.3
Glyceryl monostearate 1.1
γ-oryzanol 1.0
Carboxyvinyl polymer 0.3
Triethanolamine 0.22
Sodium edetate 0.05
Purified water remaining
100%

Example 17 Cream Sodium chondroitin sulfate 0.1
Glycerin 5.0
Ethoxydiglycol 8.0
Trimethylolpropane tri-2-ethylhexanoate 5.0
Propylene glycol dicaprylate 0.5
Dipotassium glycyrrhizinate 0.1
White petrolatum 10.0
Cetanol 2.0
Polyoxyethylene hydrogenated castor oil 40 1.9
Glyceryl monostearate 1.1
Sodium ascorbate phosphate 0.5
Carboxyvinyl polymer 0.3
Triethanolamine 0.22
Sodium edetate 0.05
Purified water remaining
100%

Example 18 Cream Ceramide 3 0.05
Glycerin 3.0
1,3-butylene glycol 2.0
Ethoxydiglycol 5.0
Cetyl 2-ethylhexanoate 15.0
Tri-2-ethylhexanoic acid trimethylolpropane 0.5
Pyridoxine hydrochloride 0.1
Glyceryl monostearate 3.5
Polyoxyethylene cetyl ether 3.5
Carboxyvinyl polymer 0.8
Triethanolamine 0.22
Sodium edetate 0.05
Purified water remaining
100%

Example 19 Nonaqueous Liquid Crystal Gel Hydrogenated Soybean Lecithin 2.0
Ethoxydiglycol 10.0
Ascorbyl tetra-2-hexyldecanoate 40.0
Tri (capryl / capric acid) glyceryl 5.0
Squalane 3.0
Sodium edetate 0.05
Glycerin remaining
100%

Example 20 Nonaqueous Liquid Crystal Gel Hydrogenated Soybean Lecithin 1.0
Propylene glycol 3.0
Ethoxydiglycol 10.0
Tri-2-isostearic acid trimethylolpropane 20.0
Tri (capryl / capric acid) glyceryl 1.0
Retinol palmitate 0.01
Methylphenylpolysiloxane 5.0
Sodium edetate 0.05
Glycerin remaining
100%

Example 21 Microemulsion Hydrogenated Soy Lecithin 2.0
Ethoxydiglycol 10.0
Tetra-2-ethylhexanoic acid pentaerythritol 25.0
Propylene glycol dicaprate 5.0
Purified water 5.0
Sodium edetate 0.05
Glycerin remaining
100%

Example 22 Microemulsion Hydrogenated Soy Lecithin 2.0
Ethoxydiglycol 10.0
Ascorbyl tetra-2-hexyldecanoate 10.0
δ-tocolatinate 0.1
Tri (capryl / capric acid) glyceryl 5.0
Purified water 5.0
Sodium edetate 0.05
Glycerin remaining
100%

Example 22 Microemulsion Hydrogenated Soy Lecithin 2.0
Ethoxydiglycol 10.0
Ascorbyl tetra-2-hexyldecanoate 10.0
Tocopherol acetate 5.0
Tetra-2-ethylhexanoic acid pentaerythritol 5.0
Purified water 5.0
Sodium edetate 0.05
Glycerin remaining
100%

Example 22 Nonaqueous Liquid Crystal Gel Hydrogenated Soybean Lecithin 4.0
Ethoxydiglycol 10.0
Ascorbyl tetra-2-hexyldecanoate 20.0
Methylphenylpolysiloxane 5.0
Tetra-2-ethylhexanoic acid pentaerythritol 5.0
Glycerin remaining
100%

Claims (3)

A skin external preparation containing (A) a natural surfactant, (B) glycol or glycerin, (C) liquid ester oil, and (D) glycol ether. Glycol ether is ethylene glycol monoether, ethylene glycol diether, propylene glycol monoether, propylene glycol diether, butylene glycol monoether, butylene glycol diether, diethylene glycol monoether, diethylene glycol monoether, diethylene glycol diether, dipropylene glycol mono. The skin external preparation according to claim 1, which is one or more selected from the group consisting of ether, dipropylene glycol diether, dibutylene glycol monoether and dibutylene glycol diether. A method for improving the stability of a skin external preparation by blending glycol ether into a skin external preparation containing (A) a natural surfactant, (B) glycol or glycerin, and (C) a liquid oil.