JP2005213158A5 - - Google Patents
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- Publication number
- JP2005213158A5 JP2005213158A5 JP2004018889A JP2004018889A JP2005213158A5 JP 2005213158 A5 JP2005213158 A5 JP 2005213158A5 JP 2004018889 A JP2004018889 A JP 2004018889A JP 2004018889 A JP2004018889 A JP 2004018889A JP 2005213158 A5 JP2005213158 A5 JP 2005213158A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- adsorption
- aqueous solution
- composition
- aqueous suspension
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001184 polypeptide Polymers 0.000 claims 17
- 102000004196 processed proteins & peptides Human genes 0.000 claims 17
- 108090000765 processed proteins & peptides Proteins 0.000 claims 17
- 238000001179 sorption measurement Methods 0.000 claims 15
- 239000000203 mixture Substances 0.000 claims 14
- 239000003112 inhibitor Substances 0.000 claims 8
- 239000007864 aqueous solution Substances 0.000 claims 7
- 239000007900 aqueous suspension Substances 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 102000055006 Calcitonin Human genes 0.000 claims 4
- 108060001064 Calcitonin Proteins 0.000 claims 4
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 4
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- BBBFJLBPOGFECG-VJVYQDLKSA-N calcitonin Chemical group N([C@H](C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=1NC=NC=1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(N)=O)C(C)C)C(=O)[C@@H]1CSSC[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CO)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1 BBBFJLBPOGFECG-VJVYQDLKSA-N 0.000 claims 4
- 229960004015 calcitonin Drugs 0.000 claims 4
- 229930182817 methionine Natural products 0.000 claims 4
- 102000003982 Parathyroid hormone Human genes 0.000 claims 2
- 108090000445 Parathyroid hormone Proteins 0.000 claims 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims 2
- TVXBFESIOXBWNM-UHFFFAOYSA-N Xylitol Natural products OCCC(O)C(O)C(O)CCO TVXBFESIOXBWNM-UHFFFAOYSA-N 0.000 claims 2
- 229940088597 hormone Drugs 0.000 claims 2
- 239000005556 hormone Substances 0.000 claims 2
- 239000007951 isotonicity adjuster Substances 0.000 claims 2
- 235000010355 mannitol Nutrition 0.000 claims 2
- HEBKCHPVOIAQTA-UHFFFAOYSA-N meso ribitol Natural products OCC(O)C(O)C(O)CO HEBKCHPVOIAQTA-UHFFFAOYSA-N 0.000 claims 2
- 239000000199 parathyroid hormone Substances 0.000 claims 2
- 229960001319 parathyroid hormone Drugs 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 235000017281 sodium acetate Nutrition 0.000 claims 2
- 239000001632 sodium acetate Substances 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 235000002639 sodium chloride Nutrition 0.000 claims 2
- 239000000811 xylitol Substances 0.000 claims 2
- 235000010447 xylitol Nutrition 0.000 claims 2
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 claims 2
- 229960002675 xylitol Drugs 0.000 claims 2
- 239000006174 pH buffer Substances 0.000 claims 1
- 239000006179 pH buffering agent Substances 0.000 claims 1
Claims (14)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004018889A JP4707327B2 (en) | 2004-01-27 | 2004-01-27 | Polypeptides adsorption inhibitors |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2004018889A JP4707327B2 (en) | 2004-01-27 | 2004-01-27 | Polypeptides adsorption inhibitors |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2005213158A JP2005213158A (en) | 2005-08-11 |
| JP2005213158A5 true JP2005213158A5 (en) | 2007-01-25 |
| JP4707327B2 JP4707327B2 (en) | 2011-06-22 |
Family
ID=34903258
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2004018889A Expired - Fee Related JP4707327B2 (en) | 2004-01-27 | 2004-01-27 | Polypeptides adsorption inhibitors |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4707327B2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20200289621A1 (en) | 2017-09-22 | 2020-09-17 | Asahi Kasei Pharma Corporation | Teriparatide-containing liquid pharmaceutical composition having excellent stability |
| EP3685850A4 (en) | 2017-09-22 | 2021-06-16 | Asahi Kasei Pharma Corporation | LIQUID PHARMACEUTICAL COMPOSITION CONTAINING TRIPARATIDE WITH EXCELLENT PHARMACODYNAMIC PROPERTIES AND / OR STABILITY |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2974722B2 (en) * | 1990-04-03 | 1999-11-10 | 帝国臓器製薬株式会社 | Calcitonin injection |
| JPH05331071A (en) * | 1992-01-17 | 1993-12-14 | Asahi Chem Ind Co Ltd | Lyophilized composition of calcitonin gene-related peptide and stabilization thereof |
| JPH07118165A (en) * | 1993-10-22 | 1995-05-09 | Asahi Chem Ind Co Ltd | Transcutaneous absorption composition containing calcitonin gene relating peptide |
| MXPA02007187A (en) * | 2000-01-25 | 2002-12-09 | Aeropharm Technology Inc | A medicinal aerosol formulation. |
| JP4071105B2 (en) * | 2000-10-18 | 2008-04-02 | マキシゲン・エイピーエス | Protein C or activated protein C-like molecule |
| PL366705A1 (en) * | 2001-04-06 | 2005-02-07 | Maxygen Holdings Ltd. | Interferon gamma polypeptide variants |
| JP4252260B2 (en) * | 2002-06-05 | 2009-04-08 | 旭化成ファーマ株式会社 | PTH stabilized aqueous solution injection |
| JP4083634B2 (en) * | 2002-07-11 | 2008-04-30 | 旭化成ファーマ株式会社 | Light stable calcitonin aqueous solution |
| WO2004007520A2 (en) * | 2002-07-12 | 2004-01-22 | Medarex, Inc. | Methods and compositions for preventing oxidative degradation of proteins |
| JP5522879B2 (en) * | 2006-01-16 | 2014-06-18 | 旭化成ファーマ株式会社 | Method for improving stability of bioactive peptide in resin container |
-
2004
- 2004-01-27 JP JP2004018889A patent/JP4707327B2/en not_active Expired - Fee Related
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