JP2004515315A - Application device - Google Patents

Abstract

An application device comprising an applicator substrate, a patch sandwiched therebetween, and a release substrate. The application substrate and release substrate allow the user to grip the applicator substrate tab, grip the release substrate tab, and apply the patch to the target surface without releasing the first gripped tab It has a grippable tab.

Description

[0001]
(Cross-reference)
This application claims priority from provisional application 60 / 255,045 filed on December 12, 2000, according to 35 USC 119 (e) Chapter 35.
[0002]
(Technical field)
The present invention relates to an application device for applying an adhesive patch.
[0003]
(Background of the Invention)
While many application devices for adhesive patches have been described, various problems are associated with their use. For example, U.S. Pat. Nos. 4,913,138, 5,106,629, 5,397,297, 5,511,689, 5,656,282, 5,685,833. No. 5,891,078, 6,129,929, and PCT International Publication No. WO 98/17216. Many uses of these devices, for example, in the application of adhesive patches, result in patch curl or adhesion to itself before it can be secured to the target surface. Another problem with many application devices is that the user is forced to touch the surface of the patch during application. This is particularly a problem when the patch is intended to be sterile or includes an adhesive surface. Such contact contaminates the patch or reduces the adhesion of the patch.
[0004]
In the art, there are reportedly one-handed patch application devices that minimize the event that a user must touch the surface of the patch. However, many of these devices have a tab on the application member that overlaps the release member. Such a design makes it difficult for the user to grip the tab and pull the application member away from the release member. Still other one-handed patch application devices require the user to grip the application member in one place, peel the application member from the release member, and then hold the application member in another location to apply the patch to the target surface And Still other devices have an adhesive disposed throughout the application member so that active materials, dyes, etc. diffuse from the patch into the adhesive, reducing the effectiveness of the patch. Still other devices have a limited number of adhesives that can be utilized and function as one-handed devices. Still other devices have limited manufacturing tolerances during assembly.
[0005]
For the above reasons, the application member without the patch curling itself, the patch being unnecessarily touched by the user, the patch being applied to the target surface and the user first releasing the gripped application member With minimal diffusion of the active substance of the patch into the adhesive placed on it, the user from the application component containing the patch with a wide variety of practicable adhesives and materials and with enhanced manufacturing tolerances There is a continuing need for a patch application device that allows the release member to be easily peeled and then applied to the target surface to thereby peel off the application member having a patch applied to the target surface. .
[0006]
(Summary of Invention)
The present invention provides an application device comprising an applicator substrate, a release substrate, and a patch that is sandwiched between and suitable for application to a target surface. The applicator substrate is substantially planar and includes an outwardly graspable tab. The applicator substrate has an inner surface with an adhesive means comprising an adhesive region. The patch is substantially planar and has a first surface and a second surface. The adhesive region of the applicator substrate releasably affixes the first surface of the patch, thereby forming a first peel bond, thereby forming an applicator substrate / patch combination (hereinafter referred to as a “bond”). ). The conjugate has an upper surface. The second surface of the patch is provided with an adhesive means. The release substrate is substantially planar and includes a grippable tab extending outward and an inner surface. The inner surface of the release substrate is releasably affixed to the upper surface of the bonded body, thereby forming a second peel bond. Furthermore, the tab of the peeling base material pasted so as to be peelable is displaced laterally from the bonded body. The strength of the first peel bond is greater than the strength of the second peel bond, thus allowing the user to separate the release substrate from the bond. When the release substrate is peeled off and the upper surface of the bonded body is applied to the target surface, an adhesive bond is formed between the second surface of the patch and the target surface. Because the strength of the adhesive bond is greater than the strength of the first peel bond, it is possible to peel the applicator substrate from the patch after the patch has been applied to the target surface.
[0007]
(Detailed description of the invention)
DETAILED DESCRIPTION OF THE INVENTION While the specification sets forth claims that particularly point out and distinctly claim the invention, it is believed that the present invention will be better understood from the following description taken in conjunction with the accompanying drawings. Reference will now be made in detail to embodiments of the present invention, examples of which are illustrated in the accompanying drawings, wherein like numerals indicate like elements in all figures, and identical last two digits (eg, 20 and 120) Alternatively, elements having alphabetic subscripts (for example, 22A and 22B) indicate the same element.
[0008]
1 and 2 illustrate a first embodiment of the present invention. 1 is an exploded view, and FIG. 2 is a plan view. The thin layer application device 20 of the present invention comprises a substantially planar applicator substrate 32, a substantially planar patch 44 sandwiched therebetween, and a substantially planar release substrate 24. Applicator substrate 32 includes a grippable tab 36 extending outwardly therefrom. Applicator substrate 32 also includes an inner surface 48. The inner surface 48 of the applicator substrate 32 comprises an adhesive means that is bonded, coated, formed, laminated, or otherwise applied to the inner surface 48 of the applicator substrate 32 to provide an adhesive region 40. 1 and 2 extends about 40% of the inner surface 48, but does not extend to the tab 36 of the applicator substrate 32. Preferably, the adhesion area extends from about 1% to about 95%, more preferably from about 20% to about 60%.
[0009]
Still referring to FIGS. 1 and 2, the apparatus 20 further comprises a substantially planar patch 44 sandwiched between the applicator substrate 32 and the release substrate 24. The patch 44 includes a first surface 56 and a second surface 60. The adhesive region 40 is partially below the patch 44 and releasably adheres the patch 44 to the inner surface 36 of the applicator substrate 32. The adhesive region 40 also adheres the release substrate 24 in a peelable manner. The first surface 56 of the patch 44 is releasably affixed to the inner surface 48 of the applicator substrate 32 by adhesive means (having an adhesive region 40) to form a first peel bond, thereby creating an applicator substrate / A combined patch 95 (hereinafter referred to as “combined body”) is formed. As used herein, “peel bond” means a bond formed between two surfaces that adhere to each other as measured by bond strength. As used herein, “bonding force” means the amount of force required to peel two surfaces from each other, thereby measuring the strength of the bond. Thus, if the strength of the first peel bond is greater than the strength of the second peel bond, the bond is larger than the surface constituting the second peel bond to peel off the surface constituting the first bond. Power is needed.
[0010]
As shown in FIG. 2, the adhesive region 40 that bonds the first surface 56 of the patch 44 includes an adhesive contact region having a front edge contact region 41 and a rear edge contact region 42. Preferably, the releasably applied patch 44 does not overlap the tab 36 of the applicator substrate 32. The combination 95 has an upper surface (not shown).
As shown in FIG. 1, the second surface 60 of the patch 44 includes bonding means (not shown) that are bonded, coated, formed, laminated, or otherwise affixed in the same manner as the second surface 60 of the patch 44. The adhesive means of the second surface 60 of the patch 44 is preferably continuous with the second surface 60 of the patch 44. The adhesive means of the second surface 60 of the patch 44 is exposed on the upper surface of the bonded body 95. Although not shown in FIG. 1, when the user applies the upper surface of the conjugate 95 to the target surface, the adhesive means of the second surface 60 of the patch 44 applies the patch 44 to the target surface, thereby forming an adhesive bond. To do. The strength of the adhesive bond is measured by the bond strength.
[0011]
With reference to FIGS. 1 and 2, the apparatus 20 includes a release substrate 24 with a grippable tab 28 extending outwardly therefrom. The release substrate 24 includes an inner surface 68 that is releasably affixed to the upper surface of the bonded body 95, thereby forming a second peel bond. The adhesive means of the second surface 60 of the patch 44 or the adhesive means of the inner surface 48 of the applicator substrate 32, or a combination thereof, releasably adheres the release substrate 24 to the bonded body 95. Preferably, when the release substrate 24 is releasably affixed to the conjugate 95, the patch 44 sandwiched therebetween is confined between the applicator substrate 32 and the release substrate 24 and thereby for the patch 44. Constitute a closed container.
[0012]
Referring to FIGS. 1 and 2, when assembled as device 20, tabs 28 that extend outside release substrate 24 are laterally offset from coupling body 95 to facilitate gripping by the user. As used herein, “laterally offset” means that the peelable peelable release substrate is at least partially offset laterally from the combination 95 comprising the tabs 36 of the applicator substrate 32. Means that. In one embodiment, the tabs 28 of the release substrate 24 are completely laterally offset from the combination 95. As shown, the grippable tabs 36 and 28 of the release substrate 24 and applicator substrate 32 are laterally offset from each other and are not coupled together. Each tab 36 and 28 is arranged so that the user can grip each tab 36 and 28 simultaneously without having to separate them with a finger. As shown, both tabs 36 and 28 are free to grip.
[0013]
To facilitate use of the device 20, the tabs 36, 28 of the applicator substrate 32 and release substrate 24 may be the same, including color, print, label, different tab shapes / dimensions, material transparency / It can be identified by various means including opacity, or any combination thereof. The device 20 may be accompanied by instructions detailing how the device 20 is applied.
[0014]
Applicants have confirmed that an important factor determining the strength of the first peel bond is the adhesive area 40, more specifically the pattern of the adhesive contact area. Referring to FIGS. 1 and 2, the adhesive contact area has a leading edge contact area 41 and a trailing edge contact area 42. The patch 44 includes a peripheral side edge 45 when it is releasably affixed to the applicator substrate 32 to form a bonded body 95. As used herein, “peripheral side edge” means the side edge of the outermost peripheral boundary of the patch 44. The peripheral side edge 45 has a front edge 46, a rear edge 47, and an edge 48 that is not fixed. When the release substrate 24 is releasably attached to the bonded body 95, the leading edge 46 is near the tab of the release substrate 28. When the user peels the release substrate 24 from the bonded body 95, the tab 28 of the release substrate 24 indicates the direction in which the release substrate 24 is peeled off. As used herein, “stripping direction” means the path taken when one stack is peeled from another stack. The leading edge 46 of the patch 44 of the bond 95 is the first exposed surface of the patch 44 when the user peels the release substrate 24 from the bond 95. The trailing edge 47 is remote from the tab 28 of the release substrate 24. As the user continues to peel the release substrate 24 from the bond 95, the trailing edge 47 is the last exposed surface of the patch 44.
[0015]
When the release substrate 24 is peeled from the bonded body 95, the leading edge contact area 41 attaches the leading edge 46 of the patch to the inner surface 48 of the applicator substrate 32. Thus, the leading edge 46 of the patch is the portion of the peripheral edge 45 of the patch 44 that is attached by the adhesive contact area and that is first exposed when the user peels the release substrate 24 from the bond. The leading edge 46 need not be continuous with the leading edge contact area 41 (shown in the first embodiment of the present invention). Preferably, the leading edge 46 comprises about 1% to about 45%, more preferably about 10% to about 30% of the total peripheral side edge 45 of the patch 44.
[0016]
Similarly, when the release substrate 24 is peeled from the bonded body 95, the trailing edge contact area 42 attaches the trailing edge 47 to the inner surface 48 of the applicator substrate 32. The leading edge 47 need not be continuous with the trailing edge contact area 42 (shown in the first embodiment of the present invention). Preferably, the trailing edge 47 preferably comprises from about 1% to about 50%, more preferably from about 10% to about 35% of the entire peripheral side edge 45 of the patch 44. In the first embodiment of the invention, the patch leading edge 46 is diagonally opposite the patch trailing edge 47. Similarly, in the first embodiment of the present invention, the leading edge contact area 41 is diagonally opposite the trailing edge contact area 42.
[0017]
The non-fixed edge 48 is a part that is not attached by the adhesive contact region of the peripheral side edge 45 of the patch 44. Preferably, the non-fixed edge comprises about 5% to about 95%, more preferably about 40% to about 80% of the total peripheral side edge 45 of the patch 44.
By attaching the leading edge 46 and the trailing edge 47, the adhesive contact area can be applied to the target surface without curling the patch 44 itself and without unnecessarily touching the patch 44 by the user. Make it easy to be done. Preferably, the leading edge contact area 46 is 0.1 cm.²~ 4000cm²Area, more preferably 0.4 cm²~ 2cm²With an area of Preferably, the trailing edge contact area 42 is 1 cm.²~ 4500cm²Area, more preferably 0.4 cm²~ 2.5cm²With an area of
[0018]
FIG. 3 is a plan view of the bonded body 195 of the second embodiment of the present invention after peeling off the peeling substrate (not shown in FIG. 3). The conjugate 195 includes a patch 144 that is releasably affixed to the applicator substrate 132, and the applicator substrate 132 includes a grippable tab 136 that extends outwardly therefrom. The applicator substrate 132 includes an adhesive means that is bonded to the applicator substrate and includes an adhesive region 140. The patch is detachably attached to the adhesive region 140 of the applicator substrate 132. The adhesive region 140 to which the patch 144 is adhered comprises an adhesive contact region having a leading edge contact region 141 and a trailing edge contact region 142, each of which is a curved “scallop shape” type. The patch 144 then includes a peripheral edge 145 having a leading edge 146, a trailing edge 147, and an edge 148 that is not fixed. Although not shown in FIG. 3, when the release substrate is releasably affixed to the combination 195, the leading edge 146 is near the release substrate tab.
[0019]
Referring to FIG. 1, when the user peels the release substrate 24 from the bonded body 95, the strength of the first peel bond is such that the patch 44 remains releasably attached to the applicator substrate 32. Greater than peel bond strength. Furthermore, the strength of the adhesive bond is greater than the strength of the first peel bond so that when the user applies the upper surface of the bond 95 to the target surface, the patch 44 sticks to the target surface and peels away from the bond 95. To this end, the present invention provides an enhanced bond strength ratio between the three bonds to improve the performance of the device, providing a wider range of possible adhesive types, and a practicable patch. Providing a wider range of dimensions, providing greater tolerance to design changes and reducing the total adhesive used. In other words, using less adhesive can save manufacturing costs and reduce not only the amount of active material that can diffuse from the patch 44 to the adhesive on the inner surface 48 of the applicator substrate 32, but also the inner surface 48. The amount of extract from the adhesive to patch 44 is reduced.
[0020]
With reference to FIGS. 1 and 2, Applicant has also patterned the leading edge contact area 41 and the trailing edge contact area 42 in a sinusoidal manner as described by the first embodiment of the present invention. Confirmed that greater tolerance to manufacturing changes was shown. As used herein, “manufacturing change” means a change that occurs during many steps of mass production of the device of the present invention, such as the placement of a patch 44 on the adhesive region 40, It is not limited. For example, the patch 44 must be applied accurately to the adhesive area 40 during manufacture for many adhesive area 40 patterns. Applicants have confirmed that the patch 44 can be applied to the applicator substrate 32 with increased tolerance during manufacturing by patterning the leading edge contact area 41 and the trailing edge contact area 42 in a sinusoidal manner. . For example, Applicants have identified an embodiment of a device that exhibits a patch placement area of 122% when compared to the area of the patch. More specifically, in the previous embodiment, the inner surface of the applicator substrate that does not include the tab area is 32.5 cm.²The first surface of the patch is 18 cm²The patch placement area is 22cm²It is.
[0021]
Referring to FIG. 2, the sinusoidal pattern of the adhesive contact area may have several curves. Furthermore, these curves need not be symmetrical to each other.
Still referring to FIG. 2, the theoretical peel force (Newton) of the first peel bond is the adhesive peel force factor (Newton / cm) of the adhesive that is accepted in the industry for a maximum contact width (cm). The applicant confirmed that it was possible to foresee by making a call. As used herein, “maximum contact width” means the maximum linear dimension perpendicular to the peel direction within the leading edge contact area 41 or the trailing edge contact area 42. The actual peel force can be measured by a compression / tensile tester (Instron) or a friction / peeling tester (Thwing Albert).
[0022]
FIG. 4 is a schematic diagram of a suitable method for manufacturing the application device herein. This modified flow chart generally represents two paths that merge and combine to form the final application device product. The manufacturer first combines a web of overlapping release web and patch web into a stock roll (manufactured by Watson Laboratories, Inc., Salt Lake City, Utah). But not limited to this). The manufacturer also first combines the applicator substrate web with the web of adhesive web and adhesive web release liner cut into the desired pattern into a stock roll (manufacturer is Marion, Inc.). Indianapolis, Indiana, but not limited to). The first path of the deformation flow chart begins with the stock release substrate web and patch web being unrolled (74). The unrolled method consists of converting these stock stocks in roll form into a continuous flat sheet. The second path of the deformation flowchart begins with the stock applicator substrate web, the adhesive web, and the adhesive web release liner being unwound (76). Similar to the first path, the second path unrolling process turns these stock stocks in roll form into a continuous flat sheet, while the adhesive web release liner is peeled off and rewound. (82) consist of Returning to the first path, the combined release substrate web and patch web are “kiss cut” (78), ie, cut the patch film without cutting the release liner web. Concomitantly, the unwanted patch film is peeled off for rewinding (80). In the next step in both the first path and the second path, the respective tabs of the release substrate web and the application substrate web separate (84) (86) the tab portions of each web without peeling or removing any material. ) Punched for. The first path and the second path merge in an integration step (88) where the applicator substrate web and release substrate web are combined in a registered manner. The next punch-final step (90) punches the combined web into the desired finished shape and properly opens the space of the completed application device as they move on the conveyor. The final punching process also removes unwanted material. For this purpose, a final unwinding step (92) unwinds this waste material. With respect to the final application device, the removal system (94) accepts the individual application devices coming off the conveyor and places them in the collection unit where the finished product is packaged (96). Optional packaging steps are not shown, but may be included as desired by the manufacturer.
[0023]
The device of the present invention minimizes user confusion and facilitates ease of use. Many other devices allow the user to grip the application member in one position to peel the application member from the release member, and then hold the application member in another position to apply the patch to the target surface. I need. In contrast, with reference to FIGS. 1 and 2, once the user of the present invention grips tab 36 of applicator substrate 32, he / she continues to grip tab 36 throughout the entire process of using device 20 to target patch 44. Send to the surface. In some embodiments, to deliver patch 44 to the target surface, the user continues to grip both tab 36 of applicator substrate 32 and tab 28 of release substrate 24 throughout the entire process of using apparatus 20. In other embodiments, the user continues to grip the tabs 36 of the applicator substrate 32 throughout the entire process of using the device 20, and after applying the conjugate 95 to the target surface and before peeling the applicator substrate 32. The other hand presses on the outer side of the combination (not shown), thereby attaching the patch 44 to the target surface.
[0024]
Other factors that affect bond strength (hereinafter referred to as bond strength) include the amount and type of adhesive, the type of material used and its flexibility, the size and thickness of each laminate, and the equipment Include, but are not limited to, the amount of force used to combine the laminates when constructing.
Adhesives suitable for use as any adhesive means are intended in the broadest sense. Non-limiting examples of adhesives include hook and loop closures, resin adhesives, latexes, hot melts, thermoplastic adhesives, acrylic products, vinyl acetates, natural and synthetic rubbers, natural and synthetic gums, Polysiloxanes, polyacrylates, ethylene / vinyl acetate copolymers, polyvinyl pyrrolidones, vinyl pyrrolidone copolymers and especially vinyl pyrrolidone / vinyl acetates, styrene block copolymers, natural or synthetic polysaccharides, cellulosic materials, and mixtures thereof Is mentioned.
[0025]
In one embodiment, the adhesive means is low tactile that is bonded to the first surface of the applicator substrate such that substantially all of the first adhesive means remains on the applicator substrate when the patch is peeled from the applicator substrate. It is an adhesive. Non-limiting examples of low tactile adhesives include National Starch Acrylic Adhesive # 9296.
In other embodiments, the adhesive means is a double sided high tack / low tack adhesive tape where the high tack side is bonded to the inner surface of the applicator substrate. Non-limiting examples of high-tack / low-tack adhesives include those sold by 3M under the “9415” and “9416” product brands. In yet another embodiment, the adhesive means is a double sided high tack / medium tack adhesive tape where the high tack side is bonded to the inner surface of the applicator substrate. Non-limiting examples of double-sided high tack / medium tack adhesive tapes include those available from 3M under the “9425” product brand. In yet another embodiment, the adhesive means is a low tactile acrylic adhesive that is bonded to the second surface of the patch.
[0026]
Materials suitable for use as applicator substrates, patches, and release substrates are intended in their broadest sense. Non-limiting examples include polyethylene, polyester, polypropylene, polyurethane, polyolefin, polyvinyl alcohol, polyvinyl chloride, polyvinylidene, polyamide, vinyl acetate resin, ethylene / vinyl acetate copolymers, ethylene / ethyl acrylate copolymers, metal vapor. Examples include vapor deposited films or sheets thereof, rubber sheets or films, foamed synthetic resin sheets or films, nonwoven fabrics, fabrics, knitted fabrics, foils, and paper. These materials can be used alone or in combination as a laminate or as a coextrusion to form applicator substrates, patches, and release substrates. The release liner may also be coated with a coating material such as silicone, Teflon ™, or a thermoplastic such as polyester, polyvinyl resin, polyethylene, or cellulose acetate. By way of example only, different materials, manufacturing methods, and specifications are described by Joseph F. Hanlon's “Handbook of Package Engineering” (Technomic Publishing Co.). 1992), which is incorporated herein by reference.
[0027]
In one embodiment, the applicator substrate is a polyester film. In other embodiments, the patch is a polyethylene film. In yet another embodiment, the release substrate is a siliconized polyester.
Flexibility affects the tear-off bond. Also, the type of material and its thickness determine flexibility. Preferably, the applicator substrate has a thickness of 0.002 cm to 0.1 cm, more preferably 0.005 cm to 0.02 cm. Preferably, the patch has a thickness of 0.002 cm to 0.05 cm, more preferably 0.005 cm to 0.013 cm. Preferably, the release substrate has a thickness of 0.002 cm to 0.1 cm, more preferably 0.005 cm to 0.013 cm. In one embodiment, the release substrate is more flexible than the application substrate. Flexibility can be measured by a compression / tensile tester (Instron).
[0028]
The dimensions of each stack of devices may vary. Preferably, the applicator substrate is 1 cm²~ 5000cm²Area, more preferably 25 cm²~ 40cm²Having an area of Preferably, the adhesion area is 0.5 cm.²~ 4800cm²Area, more preferably 5cm²~ 20cm²Having an area of Preferably, the patch is 0.5 cm²~ 4800cm²Area, more preferably 5cm²~ 28cm²Having an area of Preferably, the release substrate is 1 cm²~ 5000cm²Area, more preferably 25 cm²~ 40cm²Having an area of
[0029]
The amount of force used to combine the laminates when assembling the device 20 affects the peel force. Preferably, the integration force is about 1 KPa to 175 KPa, more preferably about 5 KPa to about 40 KPa.
The patch of the present invention can be applied to a target surface for a number of purposes. For example, a patch containing latex may be applied to the hole to repair a punctured tire. The patch seals the hole and prevents air from escaping. A sterile patch containing gauze may be applied to the skin wound to stop bleeding or facilitate recovery. To apply the sticker, a patch with an image may be applied to the surface. Single or double sided tape may be applied to the surface using an application substrate. Large area patches containing images, patterns, or blanks may be applied like “shelf paper” using an application substrate. A patch containing peroxide may be applied to the teeth as a whitening strip. Some other examples include patching the target surface where reinforcement, protection from abrasion, protective padding, or an absorbent with a cushion is required.
[0030]
In other examples, the patch is applied to the skin for cosmetic or medical purposes. In such examples, the patch includes a peelable cosmetic or medical ingredient. Such ingredients, hereinafter referred to as “active substances”, can be water soluble, oil soluble, or soluble in both water and oil. Antibacterial agents, redness substances, analgesics, hormones, antiseborrheic agents, antipsoriatic agents, keratolytic agents and the like are included in such ingredients. Such active materials can be selected from a wide variety of materials that are known to be useful when applied locally. Refer to the United States Pharmacopeia for a list of such active substances. A safe and effective amount of active substance is considered. A “safe and effective amount” of an active substance, when used in the method of the present invention, does not have excessive adverse side effects (toxicity, inflammation, or allergic reaction) and corresponds at a reasonable benefit / risk ratio. An effective amount as a cosmetic or medical ingredient.
[0031]
When the patch is intended to deliver an active substance such as a drug, the patch may also include a drug known to facilitate the delivery of the drug through the skin or mucosa. These drugs have been referred to as skin penetration aids, reaction promoters, adjuvants, and adsorption promoters, but are collectively referred to herein as “enhancers”.
In addition to enhancers, various pharmaceutically acceptable additives and excipients available to those skilled in the art may also be incorporated. These additives include adhesives such as aliphatic and aromatic hydrocarbons, binders such as lecithin, viscoelastic agents such as fumed silica, and diluents, stabilizers, fillers, clays, buffers. Agents, biocides, moisturizers, anti-inflammatory agents, antioxidants, preservatives, colorants and the like.
[0032]
(Example)
Example 1
As illustrated in FIGS. 1 and 2, the application device of the present invention is manufactured by combining stacked bodies as follows.
First, the applicator substrate is stamped from a sheet of polyester film purchased from Marion, Inc. with a “Type D Mylar” product brand thickness of 0.127 mm. The applicator substrate has a total width of 6 cm and a total length of 6.5 cm (including tabs) and 33 cm²Of which the tab is 3cm²Having an area of
[0033]
Second, the adhesive means for the inner surface of the applicator substrate is a double-sided tape purchased under the product name “9596” from 3M Converter Markets, where the high tack side is bonded to the inner surface of the applicator substrate. A high-tack / low-tack adhesive. Thereafter, the adhesive area is kiss-cut so that the front contact area and the rear edge contact area have a sinusoidal pattern as illustrated in FIG. Bonding area is 13cm²It is. Leading edge contact area is 0.7cm²The trailing edge contact area is 0.8 cm²It is.
[0034]
Third, the patch is punched from a sheet of polyethylene film purchased from 3M with a product grade of “# 9720” with a thickness of 0.008 cm. However, before being punched out, the adhesive means on the second surface of the patch is coated on the sheet. The adhesive means is an acrylic adhesive purchased from National Starch and Adhesives under the "Dura-Tak 87-2888" product brand where the adhesive is continuous with the sheet. The patch is 3.5cm wide and 5cm long and 14cm²The sheet is stamped from a sheet having a coated acrylic adhesive so as to have an elliptical shape with a total area of. The patch is placed over the adhesive area so that the leading edge is 20% of the peripheral edge, the trailing edge is 21%, and the non-fixed edge is 59%.
[0035]
Finally, the release substrate is stamped from a siliconized polyester sheet purchased from Loparex with a product grade of “3 mil CL PET EXP 1000 EXP = X6AA12HZ” having a thickness of 0.008 cm. The release substrate has a total width of 6 cm and a total length of 6.5 cm (including tabs) and 33 cm.²Of which the tab is 3cm²Having an area of
The device stacks are combined at a production rate of 120 patches / min with a force of 7 KPa.
The peel force for the first peel bond is 0.056 N, the peel force for the second peel bond is 0.007 N, and the peel force for the adhesive bond is 0.088 N.
The type of patch can be used to deliver it as part of hormonal therapy to a human female patient in need of hormones.
[0036]
Example 2
A set of tools for applying hormone patches according to the present invention is contained in a single container as follows.
[0037]
Tool set
Application device according to the first embodiment.
A safe and effective amount comprising 14.2 mg of testosterone is coated onto the patch by conventional means.
Instruction for use.
A user who needs a hormonal patch applies a patch containing testosterone using an application device according to the instructions in the tool set.
While particular embodiments of the present invention have been illustrated and described, it would be obvious to those skilled in the art that various changes and modifications may be made without departing from the spirit and scope of the invention. All such modifications that are within the scope are intended to be covered by the appended claims.
[Brief description of the drawings]
FIG. 1 is an exploded view of a first embodiment of an application device made in accordance with the present invention.
FIG. 2 is a plan view of the first embodiment of the present invention before peeling off the peeling substrate.
FIG. 3 is a plan view of a second embodiment of the present invention after peeling off the peeling substrate.
FIG. 4 is a schematic representation of a suitable method for manufacturing the first embodiment of the present invention.

Claims (10)

A substantially planar applicator substrate 32 with an outwardly extending grippable tab 36 and an inner surface 48, a substantially planar patch 44 with a first surface 56 and a second surface 60, and an outwardly extending grip A laminar application device 20 for applying a sandwiched patch 44 to a target surface comprising a possible tab 28 and a substantially planar release substrate 24 comprising an inner surface 68;
The inner surface 48 of the applicator substrate 32 comprises an adhesive means;
The second surface 60 of the patch 44 comprises an adhesive means;
The adhesive means of the inner surface 48 of the applicator substrate 32 releasably affixes the first surface 56 of the patch 44 to the inner surface 68 of the patch 44, thereby forming a first peel bond; Thereby forming an applicator substrate / patch combination 95 with an inner surface,
The release substrate 24 is releasably affixed to the upper surface of the bonded body, thereby forming a second peel bond, and the tab 28 of the peeled substrate 24 is transverse to the bonded body 95. Is displaced in the direction,
The strength of the first peel bond is greater than the strength of the second peel bond;
A device wherein the strength of the adhesive bond between the adhesive means of the second surface 60 of the patch 44 and the target surface is greater than the strength of the first peel bond. The adhesive means of the inner surface 48 of the applicator substrate 32 further comprises an adhesive region 40 comprising an adhesive contact region;
The adhesive contact area comprises a leading edge contact area 41;
The patch 44 comprises a peripheral edge 45, the peripheral edge comprising a front edge 46 and an unsecured edge 47;
The leading edge 46 is near the tab 28 of the peelable release substrate 24;
The apparatus of claim 1, wherein the leading edge contact area (41) attaches the leading edge (46) to the inner surface (48) of the applicator substrate (32). The adhesive contact area 40 further comprises a trailing edge contact area 42;
The peripheral side edge 45 further includes a rear edge 47,
The trailing edge 47 is remote from the tab 28 of the peelable release substrate 24;
The apparatus of claim 2, wherein the trailing edge contact area 42 attaches the trailing edge 47 to the inner surface 48 of the applicator substrate 32. And a substantially planar applicator substrate 32 with an inner surface 48, a substantially planar patch 44 with a first surface 56 and a second surface 60, and a graspable means 28. A laminar application device 20 for applying a sandwiched patch 44 to a target surface comprising a substantially planar release substrate 24 comprising an inner surface 68;
The inner surface 48 of the applicator substrate 32 comprises an adhesive means;
The second surface of the patch 60 comprises an adhesive means;
The applicator comprising the adhesive means of the inner surface 48 of the applicator substrate 32 releasably affixes the first surface 56 of the patch 44, thereby forming a first peel bond, thereby providing an inner surface Forming a substrate / patch combination 95;
The release substrate 24 is releasably affixed to the inner surface of the combination 95, thereby forming a second peel bond,
The adhesive means of the inner surface 48 of the applicator substrate 32 comprises an adhesive region 40 including an adhesive contact region;
The adhesive contact area has a leading edge contact area 41 and a trailing edge contact area 42;
The patch 44 includes a peripheral side edge 45, and the peripheral side edge has a front edge 46, a rear edge 47, and an unfixed edge 47.
The leading edge 46 is near the grippable means of the peelable peelable release substrate 28;
The trailing edge 47 is remote from the grippable means of the peelable peelable substrate 28;
The leading edge contact area 41 attaches the leading edge 46 to the inner surface 48 of the applicator substrate 32;
The trailing edge contact area 42 attaches the trailing edge 47 to the inner surface 48 of the applicator substrate 32;
A device wherein the strength of the first peel bond is greater than the strength of the second peel bond. The apparatus of claim 4 wherein the strength of the adhesive bond between the adhesive means of the second surface 60 of the patch 44 and the target surface is greater than the strength of the first peel bond. The applicator substrate 32 and the grippable means 36, 28 of the release substrate 24 are outwardly extending tabs 36, 28, and the tab 28 of the release substrate 24 is laterally offset from the combination 95. 6. The apparatus of claim 5, wherein The apparatus according to claim 3 or 6, wherein at least one of the leading edge contact area 41 or the trailing edge contact area 42 has a sinusoidal pattern. The apparatus of claim 3, 6, or 7, wherein the adhesive region 32 is configured to surround the patch 44. 10. A device according to claim 3, 6, 7, or 9, wherein the patch 44 further comprises an active substance. The apparatus of claim 3, 6, 7, 8, or 9, wherein the tabs (28) of the release substrate (24) are completely laterally offset from the combination (95).

Images