JP2004352612A - Artificial tooth stabilizer - Google Patents
Artificial tooth stabilizer Download PDFInfo
- Publication number
- JP2004352612A JP2004352612A JP2003098637A JP2003098637A JP2004352612A JP 2004352612 A JP2004352612 A JP 2004352612A JP 2003098637 A JP2003098637 A JP 2003098637A JP 2003098637 A JP2003098637 A JP 2003098637A JP 2004352612 A JP2004352612 A JP 2004352612A
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- Prior art keywords
- vinyl acetate
- acetate resin
- polymerization degree
- denture
- denture stabilizer
- Prior art date
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- 239000003381 stabilizer Substances 0.000 title claims abstract description 71
- 238000006116 polymerization reaction Methods 0.000 claims abstract description 72
- 239000011347 resin Substances 0.000 claims abstract description 68
- 229920005989 resin Polymers 0.000 claims abstract description 68
- XTXRWKRVRITETP-UHFFFAOYSA-N Vinyl acetate Chemical compound CC(=O)OC=C XTXRWKRVRITETP-UHFFFAOYSA-N 0.000 claims abstract description 64
- 238000013329 compounding Methods 0.000 claims abstract 2
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- 210000003811 finger Anatomy 0.000 description 33
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Abstract
Description
【０００１】
【発明の属する技術分野】
この発明は、義歯床と顎堤の間の隙間に充填して、義歯のガタツキをなくし咀嚼力の低下を改善するために用いられるペーストタイプの義歯安定剤に関し、さらに詳しくは、義歯床の裏面に塗り付けて装着する際に指への付着量が少なく使用感に優れた義歯安定剤に関する。
【０００２】
【従来の技術】
義歯安定剤として、従来、平均重合度２００〜５００の低重合度酢酸ビニル樹脂、平均重合度１０００〜２０００の中重合度酢酸ビニル樹脂および平均重合度５０００〜７０００の高重合度酢酸ビニル樹脂を、それぞれ所定の配合量で配合してなるもの（特許文献１参照）や、アクリル酸低級アルキルとメタアクリル酸低級アルキルとメタアクリル酸塩化トリメチルアンモニウムエチルとを構成成分とする三元共重合体をベースとしたもの（特許文献２参照）が提案されている。
【０００３】
【非特許文献１】
特開昭６０−２５３４４０号公報。
【０００４】
【非特許文献２】
特開平２−１２４８０８号公報。
【０００５】
【発明が解決しようとする課題】
義歯安定剤は、通常、チューブ容器に収容された包装形態をとり、使用に当たりこれをチューブ容器から押出し、指を使って義歯床の裏面すなわち接触面に塗り付けて装着する。この時、義歯安定剤が指に多く付くと使用者に不快な感触を与えるので、義歯安定剤の指への付着量はできるだけ少なくすることが望まれる。
【０００６】
上記特許文献に提案の義歯安定剤はいずれも、義歯床の裏面に塗り付ける際に指にかなりの量付着し、使い心地に問題があった。
【０００７】
この発明は、上述のような実状に鑑み、指への義歯安定剤の付着量が少なくて使用感に優れた義歯安定剤を提供することを課題とする。
【０００８】
【課題を解決するための手段】
本発明者らは、上記課題を解決すべく研究を重ねた結果、酢酸ビニル樹脂として特定の重合度を有する３種の樹脂を組み合わせて用いると、指への義歯安定剤の付着量が少なくて不快な使用感がない義歯安定剤が得られるという知見を得、この発明を完成した。
【０００９】
すなわち、この発明による義歯安定剤は、酢酸ビニル樹脂として平均重合度６００〜９００の低重合度酢酸ビニル樹脂、平均重合度１０００〜２０００の中重合度酢酸ビニル樹脂および平均重合度４０００〜７０００の高重合度酢酸ビニル樹脂を主成分として含むものである。
【００１０】
【発明の実施の形態】
以下、この発明の義歯安定剤を構成する各成分および義歯安定剤の製造法について説明する。
【００１１】
この発明による義歯安定剤の主成分である酢酸ビニル樹脂は、低重合度のもの、中重合度のものおよび高重合度のものの３種の酢酸ビニル樹脂からなる。低重合度の酢酸ビニル樹脂としては、平均重合度６００〜９００、好ましくは７００〜８５０のものが用いられる。中重合度の酢酸ビニル樹脂としては、平均重合度１０００〜２０００、好ましくは１２００〜１５００のものが用いられる。高重合度の酢酸ビニル樹脂としては、平均重合度４０００〜７０００、好ましくは４５００〜６５００のものが用いられる。
【００１２】
義歯安定剤の全体量に対する酢酸ビニル樹脂の配合量（低重合度のもの、中重合度のものおよび高重合度のものの配合量の総和）は、３０〜８０重量％、好ましくは４０〜６５．５重量％である。酢酸ビニル樹脂の配合量が少なすぎると、指への付着量が増加し、良好な使用感が得られず、多すぎると、義歯安定剤が固くなり、チューブ容器から押出しにくく、義歯への塗布が容易にできない。
【００１３】
酢酸ビニル樹脂として低重合度酢酸ビニル樹脂、中重合度酢酸ビニル樹脂、高重合度酢酸ビニル樹脂のそれぞれの配合割合は、３００〜６００：３００〜６００：１〜８、好ましくは２００〜２５０：２００〜２５０：１〜３である。低重合度酢酸ビニル樹脂及び中重合度酢酸ビニル樹脂の各配合割合が低すぎると、義歯安定剤が固くなり、チューブ容器から押出しにくく、義歯への塗布が容易にできない。低重合度酢酸ビニル樹脂及び中重合度酢酸ビニル樹脂の各配合割合が高すぎると、指への付着量が増加し、良好な使用感が得られない上に、義歯安定剤が曳糸性を示し、取扱いが難しくなる。高重合度酢酸ビニル樹脂の配合割合が低すぎると、指への付着量が増加し、良好な使用感が得られず、高すぎると、義歯安定剤が固くなり、チューブ容器から押出しにくく、義歯への塗布が容易にできない。
【００１４】
上記配合量および配合割合が上述した各範囲内にある場合は、指への義歯安定剤の付着量が少なくて不快な使用感がない。
【００１５】
この発明による義歯安定剤の粘度は３０００００〜９０００００センチポイズ、好ましくは４０００００〜８０００００センチポイズである。義歯安定剤の粘度が低すぎると、指への付着量が増加し、良好な使用感が得られず、高すぎると、義歯安定剤が固くなり、チューブ容器から押出しにくく、義歯への塗布が容易にできない。義歯安定剤の粘度が上記範囲にある場合、使用感が良好である上に、チューブ容器からの義歯安定剤の押出しがスムーズになし得る。
【００１６】
この発明による義歯安定剤は、アクリル酸低級アルキルとメタアクリル酸低級アルキルとメタアクリル酸塩化トリメチルアンモニウムエチルとを構成成分とする三元共重合体（以下、これを単に「三元共重合体」という）を含んでいてもよい。
【００１７】
三元共重合体における低級アルキルは、メチル、エチル、プロピル、ブチル等の炭素数１〜６のアルキルを示す。特に好ましい三元共重合体はアクリル酸エチルとメタアクリル酸メチルと比較的少量のメタアクリル酸塩化トリメチルアンモニウムエチルとからなるものである。この好ましい三元共重合体としては、ローム・ファルマ（Ｒｏｈｍ Ｐｈａｒｍａ）社から「オイドラギット（Ｅｕｄｒａｇｉｔ） ＲＳ」の登録商標で市販されている分子量約１５０，０００のランダム共重合体を挙げることができる（以下、この市販品を「市販三元共重合体」という）。ただし、この発明で用いられる三元共重合体は市販三元共重合体に限定されない。
【００１８】
三元共重合体はこの発明による義歯安定剤の助剤として、すなわち、義歯安定剤を義歯床の接触面から剥し易くする成分として作用し、また口腔粘膜の調整剤としても有用である。
【００１９】
なお、酢酸ビニル樹脂は食品添加物としてチューインガム基礎剤などに使用されており、三元共重合体は医薬の結合剤、コーティング剤等に使用されており、いずれも安全性に問題はない。
【００２０】
この発明による義歯安定剤には、上記酢酸ビニル樹脂および三元共重合体の外に、義歯安定剤に所望の性状を与えるために可塑剤、乳化剤、粘度調整剤、剥離向上剤、水不溶性粉体、湿潤剤、防腐剤、金属石けん、香料、着色料、歯垢分解酵素など公知の添加剤をこの発明の効果を損なわない限りにおいて、適宜配合してもよい。
【００２１】
可塑剤としては、ミツロウ、木ロウ、カルナウバロウ、キャンデリラワックスが例示される。
【００２２】
乳化剤としては、グリセリンモノステアレートのようなグリセリンの脂肪酸エステル、ソルビタンモノステアレートのようなソルビタンの脂肪酸エステルが例示される。
【００２３】
粘度調整剤は義歯安定剤の粘度を調整するもので、エタノール好ましくは無水エタノール、水がそれぞれ通常１０〜２５重量％配合され、場合によってはグリセリン、プロピレングリコール等が併用される。エタノールの配合量が少なすぎると、酢酸ビニル樹脂を溶解することができなくなるため、同樹脂を均一に混練することができず、多すぎると指への付着量が増加し、良好な使用感が得られない。水の配合量が少なすぎると、指への付着量が増加し、良好な使用感が得られず、多すぎると、義歯安定剤が固くなり、チューブ容器から押出しにくく、義歯への塗布が容易にできない。
【００２４】
剥離向上剤は、義歯の使用後に義歯安定剤を義歯床の接触面から剥し易くするもので、ポリブテン、ポリイソブチレン、炭酸カルシウム、リン酸カルシウム、ベントナイト、二酸化ケイ素等が例示される。
【００２５】
水不溶性粉体としては、炭酸カルシウム、リン酸カルシウム、プラスチックパウダー、タルク、シリカ等が例示される。
【００２６】
湿潤剤としては、ポリエチレングリコール、ポリプロピレングリコール、グリセリン、ソルビット等が例示される。
【００２７】
防腐剤としては、メチルパラベン、エチルパラベンが例示される。
【００２８】
金属石けんとしては、ステアリン酸カルシウムが例示される。
【００２９】
この発明による義歯安定剤を製造するには、例えば高重合度酢酸ビニル樹脂が溶解しにくいため予めこれを無水エタノール／精製水の混合液に溶解しておき、別途、三元共重合体を無水エタノール／精製水の混合液に溶解する。こうして得られた高重合度酢酸ビニル樹脂の溶液と三元共重合体の溶液を、中重合度酢酸ビニル樹脂と低重合度酢酸ビニル樹脂が入れてあるタンクに添加して、全体を攪拌する方法が挙げられる。
【００３０】
また、予め、ステンレスビーカーに高重合度酢酸ビニル樹脂を入れ、これに精製水を加えて、樹脂を水に分散させておく。予製タンクに無水エタノールを入れておき、さらに上記高重合度酢酸ビニル樹脂分散液と三元共重合体を加えて撹拌し、高重合度酢酸ビニル樹脂と三元共重合体を無水エタノール／精製水に溶解させる。別途、本タンクに中重合度酢酸ビニル樹脂と低重合度酢酸ビニル樹脂を入れ、ここへ少量の精製水を加え、本タンク内を減圧状態に保っておく。ついで、本タンクに上記高重合度酢酸ビニル樹脂と三元共重合体の溶液を流し込み、全体を攪拌する方法なども挙げられる。
【００３１】
一般に義歯安定剤には、次に掲げるような性質を有することが求められている。すなわち、（ａ）容器からの取り出しが容易な柔軟性を有すること（チューブ容器から押出し易いこと）、（ｂ）無味、無臭、無害であり、口腔粘膜への刺激がないこと、（ｃ）義歯への塗布が容易なこと、（ｄ）適度のクッション効果を有し、使用感が良好なこと、（ｅ）義歯への適度な粘着力あるいは固着力を有し、長時間使用可能なこと、（ｆ）使用後に義歯床からの剥離が容易なこと。この発明による義歯安定剤は上記のような要件をすべて満たすものである。
【００３２】
【実施例】
つぎに、この発明を具体的に説明するために、この発明の実施例およびこれとの比較を示すための比較例をいくつか挙げ、さらに得られた義歯安定剤の性能試験結果を示す。義歯安定剤の粘度はＢ型粘度計（ＢＲＯＯＫＦＩＥＬＤ社製、「ＤＶ・ＩＩ＋」）を用い、義歯安定剤が温度条件３７±１℃に保持される条件下で測定した。
【００３３】
実施例１
重合度５５００の酢酸ビニル樹脂０．１４ｇを無水エタノールと精製水の混合液１０．３ｇに加え、スターラーで撹拌し、高重合度酢酸ビニル樹脂を混合液に溶解させた。
【００３４】
別途、無水エタノールと精製水の混合液１７．２ｇに市販三元共重合体、すなわちローム・ファルマ社製の「オイドラギット ＲＳ」３．５ｇを加え、ディスパーで回転数１５００ｒｐｍで約１時間攪拌し、市販三元共重合体を混合液に溶解させた。
【００３５】
重合度１３８０の酢酸ビニル樹脂３２．６８ｇと重合度７８０の酢酸ビニル樹脂３２．６８ｇが入れてあるタンクに、精製水３．５ｇを予め入れておき、そのタンクへ先に調製した高重合度酢酸ビニル樹脂の溶液と市販三元共重合体の溶液を添加して、全体を減圧下に脱泡させながらプラネタリーミキサーで回転数１１ｒｐｍで温度５０℃にて４５分間攪拌した。こうして得られた義歯安定剤をチューブ容器に充填した。義歯安定剤の粘度は４５００００センチポイズであった。
【００３６】
実施例２
重合度５５００の酢酸ビニル樹脂、重合度１３８０の酢酸ビニル樹脂および重合度７８０の酢酸ビニル樹脂の配合量をそれぞれ０．２６ｇ，３２．６２ｇおよび３２．６２ｇに変えた以外、実施例１と同様の操作を行い、義歯安定剤を得た。義歯安定剤の粘度は７５００００センチポイズであった。
【００３７】
比較例１
重合度７８０の酢酸ビニル樹脂の代わりに重合度３３０の酢酸ビニル樹脂を３２．６８ｇ用いた以外、実施例１と同様の操作を行い、義歯安定剤を得た。義歯安定剤の粘度は４１００００センチポイズであった。
【００３８】
比較例２
無水エタノールと精製水の混合液３１ｇに市販三元共重合体３．５ｇを加え、ディスパーで回転数１５００ｒｐｍで約１時間攪拌し、市販三元共重合体を混合液に溶解させた。
【００３９】
得られた市販三元共重合体の溶液を重合度１２００の酢酸ビニル樹脂６５．５ｇに添加して、全体を減圧下に脱泡させながらプラネタリーミキサーで回転数１１ｒｐｍで温度５０℃にて４５分間攪拌した。こうして得られた義歯安定剤の粘度は７５００００センチポイズであった。
【００４０】
実施例および比較例で用いた各成分の配合量を表１にまとめて示す。
【００４１】
【表１】
使用感試験
実施例および比較例で得られた義歯安定剤について、下記の２方法ａ）およびｂ）で使用感を評価した。
【００４３】
ａ）付着量測定
下記の方法で指への義歯安定剤の付着量を求めた。
【００４４】
▲１▼まず、重量既知のアクリル樹脂板上に義歯安定剤を１ｇ載せた。
【００４５】
▲２▼試験者の指をエタノールで十分に脱脂し、ワイパー（商品名「キムワイプ」、クレシア社製）で指をよく拭いて乾燥状態にした。
【００４６】
▲３▼この指を第一関節までアクリル樹脂板上の義歯安定剤に１０秒間圧着させた。この時、指に掛ける圧力は、指がアクリル樹脂板に接する程度とした。
【００４７】
▲４▼１０秒後、指をアクリル樹脂板から垂直に離した。
【００４８】
▲５▼アクリル樹脂板の重量を測定し、指に付いた義歯安定剤の重量を求めた。
【００４９】
得られた結果を図１に示す。
【００５０】
図１から明らかなように、実施例の義歯安定剤は比較例のものに比べ指に付きにくく、したがって使用感が改善されたことが分かる。
【００５１】
ｂ）使用感の官能試験
１０名のパネルメンバーにより下記の方法で義歯安定剤の使用感を評価した。
【００５２】
▲１▼まず、各パネルメンバーの指をエタノールで十分に脱脂し、ワイパー（商品名「キムワイプ」、クレシア社製）で指をよく拭いて乾燥状態にした。
【００５３】
▲２▼親指と人差し指の先端から第一関節までの間で義歯安定剤を約０．５ｇ押し付け、指への義歯安定剤の付き難さから付き易さまでを下記基準の評価点で示し、各評価点とその人数との積の総和を求めた。
【００５４】
１；義歯安定剤が指に全く付かない。
【００５５】
２；義歯安定剤が指に殆ど付かない。
【００５６】
３；義歯安定剤が指に少し付く。
【００５７】
４；義歯安定剤が指によく付く。
【００５８】
５；義歯安定剤が指に非常によく付く。
【００５９】
得られた結果を表２に示す。
【００６０】
【表２】
表２中、◎は総和が１０〜２０であって使用感が優れていることを示し、○は総和が２１〜３０であって使用感が良好であることを示し、△は総和が３１〜４０であって使用感が悪いことを示し、×は総和が４１〜５０であって使用感が極めて悪いことを示す。
【００６２】
表２から明らかなように、実施例の義歯安定剤は比較例のものに比べ指に付きにくく、したがって使用感が改善されたことが分かる。
【００６３】
【発明の効果】
この発明によれば、義歯床の裏面に塗り付けて装着する際に指への付着量が少なく使用感に優れる義歯安定剤を提供することができる。
【図面の簡単な説明】
【図１】使用感試験のａ）付着量測定において、義歯安定剤が指に付着した量を示すグラフである。[0001]
BACKGROUND OF THE INVENTION
The present invention relates to a paste-type denture stabilizer used for filling a gap between a denture base and a ridge and eliminating the rattle of the denture and improving the reduction of masticatory force, and more specifically, the back surface of the denture base The present invention relates to a denture stabilizer that has a small amount of adhesion to a finger and is excellent in feeling of use when being applied to a skin.
[0002]
[Prior art]
Conventionally, as a denture stabilizer, a low polymerization degree vinyl acetate resin having an average polymerization degree of 200 to 500, a medium polymerization degree vinyl acetate resin having an average polymerization degree of 1000 to 2000, and a high polymerization degree vinyl acetate resin having an average polymerization degree of 5000 to 7000, Based on ternary copolymers each comprising a predetermined blending amount (see Patent Document 1) or a terpolymer comprising lower alkyl acrylate, lower alkyl methacrylate and trimethylammonium ethyl methacrylate as components. (See Patent Document 2) has been proposed.
[0003]
[Non-Patent Document 1]
Japanese Patent Laid-Open No. 60-253440.
[0004]
[Non-Patent Document 2]
JP-A-2-124808.
[0005]
[Problems to be solved by the invention]
The denture stabilizer is usually packaged in a tube container. In use, the denture stabilizer is extruded from the tube container and applied to the back surface of the denture base, that is, the contact surface, using a finger. At this time, if a large amount of denture stabilizer is applied to the finger, the user feels uncomfortable, so it is desirable to reduce the amount of denture stabilizer attached to the finger as much as possible.
[0006]
All of the denture stabilizers proposed in the above-mentioned patent documents have a considerable amount of adhesion to the fingers when applied to the back surface of the denture base, and there is a problem in the usability.
[0007]
This invention makes it a subject to provide the denture stabilizer excellent in the usability | use_conditions with few adhesion amounts of the denture stabilizer to a finger | toe in view of the above actual conditions.
[0008]
[Means for Solving the Problems]
As a result of repeated researches to solve the above problems, the present inventors use a combination of three kinds of resins having a specific polymerization degree as a vinyl acetate resin, so that the amount of denture stabilizer attached to the finger is small. The present invention was completed by obtaining the knowledge that a denture stabilizer without an unpleasant feeling of use can be obtained.
[0009]
That is, the denture stabilizer according to the present invention comprises a low degree of polymerization vinyl acetate resin having an average degree of polymerization of 600 to 900, a medium degree of polymerization vinyl acetate resin having an average degree of polymerization of 1000 to 2000, and a high degree of polymerization of 4000 to 7000. A polymerization degree vinyl acetate resin is included as a main component.
[0010]
DETAILED DESCRIPTION OF THE INVENTION
Hereinafter, each component which comprises the denture stabilizer of this invention and the manufacturing method of a denture stabilizer are demonstrated.
[0011]
The vinyl acetate resin which is the main component of the denture stabilizer according to the present invention comprises three types of vinyl acetate resins having a low polymerization degree, a medium polymerization degree and a high polymerization degree. As the vinyl acetate resin having a low polymerization degree, those having an average polymerization degree of 600 to 900, preferably 700 to 850 are used. As the vinyl acetate resin having a medium polymerization degree, those having an average polymerization degree of 1000 to 2000, preferably 1200 to 1500 are used. As the vinyl acetate resin having a high degree of polymerization, those having an average degree of polymerization of 4000 to 7000, preferably 4500 to 6500 are used.
[0012]
The blending amount of vinyl acetate resin relative to the total amount of denture stabilizer (the total blending amount of low polymerization, medium polymerization and high polymerization) is 30 to 80% by weight, preferably 40 to 65. 5% by weight. If the amount of vinyl acetate resin is too small, the amount of adhesion to the finger will increase, and a good feeling of use will not be obtained. If it is too much, the denture stabilizer will become hard and difficult to extrude from the tube container, and it will be applied to the denture. Can not be easily.
[0013]
As the vinyl acetate resin, the blending ratios of the low polymerization degree vinyl acetate resin, medium polymerization degree vinyl acetate resin and high polymerization degree vinyl acetate resin are 300 to 600: 300 to 600: 1 to 8, preferably 200 to 250: 200. ~ 250: 1-3. If the blending ratios of the low polymerization degree vinyl acetate resin and the medium polymerization degree vinyl acetate resin are too low, the denture stabilizer becomes hard, it is difficult to extrude from the tube container, and application to the denture is not easy. If the blending ratios of the low-polymerization degree vinyl acetate resin and the medium-polymerization degree vinyl acetate resin are too high, the amount of adhesion to the finger will increase and a good feeling of use will not be obtained. Showing and difficult to handle. If the blending ratio of the high degree of polymerization vinyl acetate resin is too low, the amount of adhesion to the finger will increase, and a good feeling of use will not be obtained, and if it is too high, the denture stabilizer will become hard and difficult to extrude from the tube container. Cannot be applied easily.
[0014]
When the blending amount and blending ratio are within the ranges described above, the amount of denture stabilizer attached to the finger is small and there is no unpleasant feeling of use.
[0015]
The viscosity of the denture stabilizer according to the present invention is 300000 to 900000 centipoise, preferably 400000 to 800000 centipoise. If the viscosity of the denture stabilizer is too low, the amount of adhesion to the finger will increase, and a good feeling of use will not be obtained.If the viscosity is too high, the denture stabilizer will become hard, difficult to extrude from the tube container, and will not be applied to the denture. Can't be easy. When the viscosity of the denture stabilizer is in the above range, the feeling of use is good and the denture stabilizer can be smoothly extruded from the tube container.
[0016]
The denture stabilizer according to the present invention is a ternary copolymer (hereinafter referred to simply as “ternary copolymer”) comprising lower alkyl acrylate, lower alkyl methacrylate and trimethylammonium methacrylate. May be included).
[0017]
Lower alkyl in the ternary copolymer represents alkyl having 1 to 6 carbon atoms such as methyl, ethyl, propyl, butyl and the like. Particularly preferred terpolymers are those composed of ethyl acrylate, methyl methacrylate and a relatively small amount of trimethylammonium methacrylate. As this preferable terpolymer, there can be mentioned a random copolymer having a molecular weight of about 150,000, which is commercially available from Rohm Pharma under the registered trademark “Eudragit RS” ( Hereinafter, this commercial product is referred to as “commercially available terpolymer”). However, the ternary copolymer used in the present invention is not limited to a commercially available ternary copolymer.
[0018]
The ternary copolymer acts as an auxiliary agent for the denture stabilizer according to the present invention, that is, acts as a component that facilitates peeling of the denture stabilizer from the contact surface of the denture base, and is also useful as a preparation for the oral mucosa.
[0019]
Vinyl acetate resin is used as a food additive in chewing gum bases and the like, and terpolymers are used in pharmaceutical binders, coating agents, etc., and there are no safety problems.
[0020]
In addition to the vinyl acetate resin and the terpolymer, the denture stabilizer according to the present invention includes a plasticizer, an emulsifier, a viscosity modifier, a peeling improver, a water-insoluble powder, in order to give the denture stabilizer the desired properties. Known additives such as body, wetting agent, preservative, metal soap, fragrance, colorant, and plaque-degrading enzyme may be appropriately added as long as the effects of the present invention are not impaired.
[0021]
Examples of the plasticizer include beeswax, wood wax, carnauba wax, and candelilla wax.
[0022]
Examples of the emulsifier include glycerin fatty acid esters such as glycerin monostearate and sorbitan fatty acid esters such as sorbitan monostearate.
[0023]
The viscosity modifier is used to adjust the viscosity of the denture stabilizer, and ethanol, preferably absolute ethanol and water are each usually added in an amount of 10 to 25% by weight, and glycerin, propylene glycol and the like are used in some cases. If the blending amount of ethanol is too small, the vinyl acetate resin cannot be dissolved, so that the resin cannot be uniformly kneaded. I can't get it. If the amount of water is too small, the amount of adhesion to the finger will increase and a good feeling of use will not be obtained. If it is too large, the denture stabilizer will become hard, difficult to extrude from the tube container, and easy to apply to the denture. I can't.
[0024]
The exfoliation improver facilitates the removal of the denture stabilizer from the contact surface of the denture base after use of the denture, and examples thereof include polybutene, polyisobutylene, calcium carbonate, calcium phosphate, bentonite, and silicon dioxide.
[0025]
Examples of the water-insoluble powder include calcium carbonate, calcium phosphate, plastic powder, talc, and silica.
[0026]
Examples of the wetting agent include polyethylene glycol, polypropylene glycol, glycerin, sorbit and the like.
[0027]
Examples of the preservative include methyl paraben and ethyl paraben.
[0028]
An example of the metal soap is calcium stearate.
[0029]
In order to manufacture the denture stabilizer according to the present invention, for example, since the high polymerization degree vinyl acetate resin is difficult to dissolve, it is previously dissolved in a mixed solution of absolute ethanol / purified water, and a ternary copolymer is separately added with anhydrous Dissolve in ethanol / purified water mixture. A method of adding the solution of the high polymerization degree vinyl acetate resin and the ternary copolymer solution thus obtained to the tank containing the medium polymerization degree vinyl acetate resin and the low polymerization degree vinyl acetate resin, and stirring the whole Is mentioned.
[0030]
In addition, a high polymerization degree vinyl acetate resin is put in a stainless beaker in advance, and purified water is added thereto to disperse the resin in water. Put absolute ethanol in a pre-made tank, add the above high polymerization degree vinyl acetate resin dispersion and ternary copolymer, stir, and make high polymerization degree vinyl acetate resin and ternary copolymer in absolute ethanol / purification Dissolve in water. Separately, a medium polymerization degree vinyl acetate resin and a low polymerization degree vinyl acetate resin are put into this tank, a small amount of purified water is added thereto, and the inside of this tank is kept under reduced pressure. Next, a method of pouring the solution of the high polymerization degree vinyl acetate resin and the terpolymer into the tank and stirring the whole can be mentioned.
[0031]
In general, denture stabilizers are required to have the following properties. That is, (a) having flexibility that can be easily taken out from the container (easy to be extruded from the tube container), (b) tasteless, odorless, harmless, and no irritation to the oral mucosa, (c) denture (D) has an appropriate cushioning effect and good usability, (e) has an appropriate adhesive force or fixing force to the denture, and can be used for a long time, (F) Easy to peel off from the denture base after use. The denture stabilizer according to the present invention satisfies all the above requirements.
[0032]
【Example】
Next, in order to specifically explain the present invention, some examples of the present invention and comparative examples for showing comparison with the examples are given, and further, performance test results of the obtained denture stabilizer are shown. The viscosity of the denture stabilizer was measured using a B-type viscometer (manufactured by BROOKFIELD, “DV II +”) under the condition that the denture stabilizer is maintained at a temperature of 37 ± 1 ° C.
[0033]
Example 1
0.14 g of vinyl acetate resin having a polymerization degree of 5500 was added to 10.3 g of a mixed solution of absolute ethanol and purified water, and stirred with a stirrer to dissolve the high polymerization degree vinyl acetate resin in the mixed solution.
[0034]
Separately, 3.5 g of a commercially available terpolymer, that is, “Eudragit RS” manufactured by Rohm Pharma Co., is added to 17.2 g of a mixed solution of absolute ethanol and purified water, and stirred with a disper at a rotation speed of 1500 rpm for about 1 hour. A commercially available ternary copolymer was dissolved in the mixed solution.
[0035]
A tank containing 32.68 g of a vinyl acetate resin having a polymerization degree of 1380 and 32.68 g of a vinyl acetate resin having a polymerization degree of 780 is charged with 3.5 g of purified water in advance, and the high polymerization degree acetic acid previously prepared in the tank. A vinyl resin solution and a commercially available ternary copolymer solution were added, and the whole was degassed under reduced pressure, and stirred for 45 minutes at a temperature of 50 ° C. at a rotation speed of 11 rpm with a planetary mixer. The denture stabilizer thus obtained was filled into a tube container. The viscosity of the denture stabilizer was 450,000 centipoise.
[0036]
Example 2
Example 1 except that the blending amounts of a vinyl acetate resin with a polymerization degree of 5500, a vinyl acetate resin with a polymerization degree of 1380 and a vinyl acetate resin with a polymerization degree of 780 were changed to 0.26 g, 32.62 g and 32.62 g, respectively. The operation was performed to obtain a denture stabilizer. The viscosity of the denture stabilizer was 750000 centipoise.
[0037]
Comparative Example 1
A denture stabilizer was obtained in the same manner as in Example 1 except that 32.68 g of a vinyl acetate resin having a polymerization degree of 330 was used instead of the vinyl acetate resin having a polymerization degree of 780. The viscosity of the denture stabilizer was 410000 centipoise.
[0038]
Comparative Example 2
3.5 g of a commercially available ternary copolymer was added to 31 g of a mixed solution of absolute ethanol and purified water, and the mixture was stirred with a disper at a rotation speed of 1500 rpm for about 1 hour to dissolve the commercially available ternary copolymer in the mixed solution.
[0039]
The obtained commercially available ternary copolymer solution was added to 65.5 g of a vinyl acetate resin having a polymerization degree of 1200, and the whole was degassed under reduced pressure while rotating at 11 rpm with a planetary mixer at a temperature of 50 ° C. Stir for minutes. The viscosity of the denture stabilizer thus obtained was 750000 centipoise.
[0040]
Table 1 summarizes the amounts of each component used in the examples and comparative examples.
[0041]
[Table 1]
Usability test For the denture stabilizers obtained in Examples and Comparative Examples, the usability was evaluated by the following two methods a) and b).
[0043]
a) Measurement of adhesion amount The adhesion amount of the denture stabilizer to the finger was determined by the following method.
[0044]
(1) First, 1 g of denture stabilizer was placed on an acrylic resin plate having a known weight.
[0045]
(2) The tester's finger was thoroughly degreased with ethanol, and the finger was thoroughly wiped with a wiper (trade name “Kimwipe”, manufactured by Crecia) to make it dry.
[0046]
(3) This finger was pressed to the denture stabilizer on the acrylic resin plate for 10 seconds up to the first joint. At this time, the pressure applied to the finger was such that the finger was in contact with the acrylic resin plate.
[0047]
(4) Ten seconds later, the finger was released vertically from the acrylic resin plate.
[0048]
(5) The weight of the acrylic resin plate was measured to determine the weight of the denture stabilizer attached to the finger.
[0049]
The obtained results are shown in FIG.
[0050]
As is clear from FIG. 1, it can be seen that the denture stabilizers of the examples are less likely to stick to the fingers than those of the comparative examples, and thus the feeling of use is improved.
[0051]
b) Sensory test of feeling of use Tens of panel members evaluated the feeling of use of the denture stabilizer by the following method.
[0052]
(1) First, the fingers of each panel member were thoroughly degreased with ethanol, and the fingers were thoroughly wiped with a wiper (trade name “Kimwipe”, manufactured by Crecia) to be in a dry state.
[0053]
(2) About 0.5 g of denture stabilizer is pressed between the tip of the thumb and forefinger to the first joint, and from the difficulty to the attachment of the denture stabilizer to the finger is shown by the following evaluation points. The sum of the products of the evaluation points and the number of people was obtained.
[0054]
1; Denture stabilizer does not stick to fingers at all.
[0055]
2: Denture stabilizer hardly sticks to fingers.
[0056]
3; A denture stabilizer sticks to a finger a little.
[0057]
4; Denture stabilizer adheres well to fingers.
[0058]
5; Denture stabilizer sticks to fingers very well.
[0059]
The obtained results are shown in Table 2.
[0060]
[Table 2]
In Table 2, ◎ indicates that the sum is 10 to 20 and the usability is excellent, ○ indicates that the sum is 21 to 30 and the usability is good, and Δ indicates that the sum is 31 to 30 40 indicates that the feeling of use is bad, and x indicates that the total is 41 to 50 and the feeling of use is extremely bad.
[0062]
As is clear from Table 2, it can be seen that the denture stabilizers of the examples were less likely to stick to the fingers than those of the comparative examples, and thus the feeling of use was improved.
[0063]
【The invention's effect】
According to the present invention, it is possible to provide a denture stabilizer that has a small amount of adhesion to a finger and is excellent in feeling of use when applied to the back surface of the denture base.
[Brief description of the drawings]
BRIEF DESCRIPTION OF DRAWINGS FIG. 1 is a graph showing the amount of denture stabilizer attached to a finger in a) adhesion amount measurement of a feeling of use test.
Claims (4)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| JP2003098637A JP4415209B2 (en) | 2003-03-31 | 2003-04-01 | Denture stabilizer |
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| JP2003097457 | 2003-03-31 | ||
| JP2003098637A JP4415209B2 (en) | 2003-03-31 | 2003-04-01 | Denture stabilizer |
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| JP2004352612A true JP2004352612A (en) | 2004-12-16 |
| JP4415209B2 JP4415209B2 (en) | 2010-02-17 |
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| JP2003098637A Expired - Lifetime JP4415209B2 (en) | 2003-03-31 | 2003-04-01 | Denture stabilizer |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008253303A (en) * | 2007-03-30 | 2008-10-23 | Kobayashi Pharmaceut Co Ltd | Denture stabilizer |
| JP2009082383A (en) * | 2007-09-28 | 2009-04-23 | Kobayashi Pharmaceut Co Ltd | Denture stabilizer |
-
2003
- 2003-04-01 JP JP2003098637A patent/JP4415209B2/en not_active Expired - Lifetime
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2008253303A (en) * | 2007-03-30 | 2008-10-23 | Kobayashi Pharmaceut Co Ltd | Denture stabilizer |
| JP2009082383A (en) * | 2007-09-28 | 2009-04-23 | Kobayashi Pharmaceut Co Ltd | Denture stabilizer |
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| JP4415209B2 (en) | 2010-02-17 |
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