JP2004305725A - Hydrocolloidal material and adhesive material using the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a hydrocolloidal material having excellent adhesiveness to the applied affected area, good responsiveness to stretches of the skin and sufficient absorbency of sweat or exudate generated from the affected area capable of maintaining its shape preserving property even after absorption. <P>SOLUTION: The adhesive hydrocolloidal material is applied to the surface of the skin. The hydrocolloidal material shows following values of complex elastic modulus and phase difference when measured at 37°C: complex elastic modulus of 10,000-80,000 Pa and phase difference of 10-40° when the frequency is 0.1 Hz; complex elastic modulus of 20,000-130,000 Pa and phase difference of 20-55° when the frequency is 1.0 Hz; and complex elastic modulus of 60,000-500,000 Pa and phase differential of 25-50° when the frequency is 10.0 Hz. <P>COPYRIGHT: (C)2005,JPO&NCIPI

Description

  The present invention relates to local protection of wounds, artificially or naturally made pores, catheter introductions and the like, and absorption of liquids therefrom, or skin protection and pressure relief for pressure ulcer prevention, pharmaceutical substances The present invention relates to a medical hydrocolloid material used as a base material for delivery to the skin, and a patch using the same.

Conventional hydrocolloid materials have the following problems.
(B) Since the followability to the unevenness of the skin is poor, peeling or lifting from the skin occurs.
(B) Due to excessive adhesiveness, a lot of keratin is removed when peeling from the skin.
(C) Since the tensile stress is high, it cannot respond to skin extension, causing peeling from the skin or skin irritation due to partial pressure on the skin.
In particular, the problem (a) is closely related to the problem (b). In other words, conventional hydrocolloids have low flexibility, so when applied to uneven skin, the contact area between the hydrocolloid and the skin is low, and it is necessary to increase the adhesive strength in order to obtain the required fixability with a small contact area. was there. Therefore, there has been a tendency that the amount of exfoliation during exfoliation increases. As for the problem (c), if the adhesive force is increased in order to prevent peeling at the time of skin extension, the problem (b) is promoted. Note that the skin irregularities referred to here are body shapes and wrinkles when viewed broadly, and are skin grooves and dunes from a minute viewpoint.

  As a technique for solving these problems, proposals have been made to increase the flexibility by blending a liquid component having a plasticizing action. For example, as an adhesive sealing substance used for fistula bags, elastic bodies such as styrene-isoprene-styrene block copolymers that form a continuous phase, hydrocolloids dispersed in these, and hydrocarbon resin adhesive compositions Some gel compositions containing an oil spreader have low resistance to deformation, and quickly return to their original shape after deformation (see, for example, Patent Document 1). This uses an oil extender such as liquid paraffin to reduce the elastic modulus of the composition and exhibit low resistance to deformation. However, oil extenders are extremely low in molecular weight compared to elastic bodies, so if blended in a large amount in the composition, they tend to bleed, thereby lowering the tackiness and greatly increasing the cohesion after water absorption. There is a tendency to decrease. For this reason, there is a limit to this type of method in order to increase flexibility while maintaining the integrity after water absorption.

  Similarly, the adhesive material used in the fistula bag includes an elastomer compound composed of a high molecular weight polyisobutylene and a styrene block copolymer, a hydrocarbon plasticizer, a water-absorbing hydrocolloid, a tackifier, and an antioxidant. A pressure-bonding composition is shown (for example, see Patent Document 2). This is thought to be due to the use of high molecular weight polyisobutylene and one or more styrene block copolymers, without using low molecular weight polyisobutylene, to improve the decrease in cohesiveness caused by the addition of a conventional plasticizer.

  However, even if a certain amount of plasticizer can be added, on the other hand, there is a problem that the tackiness is reduced by the plasticizer, so that it is necessary to add a tackifying resin. By doing so, a number of different raw materials such as tackifying resins and their antioxidants are present in the composition, increasing the likelihood of substances that irritate or sensitize the skin. Further, as a characteristic of the tackifying resin, there is a characteristic that the elastic modulus at a low frequency is reduced, but the elastic modulus at a high frequency is increased. Therefore, the adhesiveness (wetting) at the time of application is improved, but on the other hand, there is a disadvantage that the stimulus given to the skin at the time of peeling increases, and considering the irritation to the skin at the time of peeling, the use of tackifier is not It is desirable to refrain.

  In addition, a pressure sensitive adhesive material comprising a mixture of a physically crosslinked solid rubber, a compatible liquid rubber, a continuous phase formed from a resin material, and a discontinuous phase containing a hydrophilic substance is shown as a wound dressing. (For example, see Patent Document 3). Here, it is described that an integrated network formed by a combination of solid rubber and liquid rubber maintains high absorbency and shape stability after absorption. However, with such knowledge alone, specific countermeasures have been disclosed for conventional problems in skin, i.e., conformability to skin irregularities, responsiveness to skin extension, and exfoliation during skin exfoliation. Absent.

JP-A-54-13693 (pages 3-8) JP-A-8-722 (pages 3-5) Special Table 2001-515091 (pages 9-15)

  The object of the present invention is to have good adhesiveness and responsiveness to skin extension to the affected area to be applied, and sufficient absorbability and shape retention after absorption to sweat and exudate generated from the affected area. It is an object of the present invention to provide a hydrocolloid material that can be maintained and can be peeled off without damaging the skin or wound surface without leaving the composition on the affected area during peeling, and a patch using the hydrocolloid material.

  Therefore, in order to solve the above-mentioned problems, the present inventor has repeatedly studied the viscoelasticity of hydrocolloids. As a result, the hydrocolloid material exhibiting a specific complex elastic modulus and phase difference under a certain condition has solved the above problems. The headline and the present invention were completed.

  That is, in the present invention, it is a hydrocolloid material applied on the skin surface, and the value of the complex elastic modulus and phase difference measured at 37 ° C. is a complex elastic modulus of 10,000 to 80000 Pa and a phase difference of 10 ° when the frequency is 0.1 Hz. It has a phase difference of 20 ° to 55 ° at a complex elastic modulus of 30000 to 130,000Pa at a frequency of ~ 40 ° and a frequency of 1.0Hz, and a phase difference of 25 ° to 50 ° at a complex elastic modulus of 60000 to 500000Pa at a frequency of 10.0Hz. is there.

  In the present invention, it is advantageous that the hydrocolloid material contains a thermoplastic elastomer, a liquid rubber compatible with the thermoplastic elastomer, and a water-soluble and / or water-insoluble hydrophilic substance. The term “compatible” as used herein refers to the property of forming a homogeneous mixture when thermoplastic elastomer and liquid rubber are mixed.

  The adhesive performance of hydrocolloids is highly related to viscoelastic behavior. Viscoelasticity is a property that has both viscosity and elasticity. That is, when an external force is applied, both deformation behavior that causes deformation (strain) and recovers to return to its original shape when the external force is removed, and viscous behavior that remains deformed and does not return to its original shape. It is a property related to a substance with This viscoelasticity is expressed quantitatively by the complex elastic modulus, also called the dynamic viscoelastic coefficient, which is a vector composition component of the viscous component and the elastic component, and is an indicator of the hardness and softness of the substance. . The ratio between the viscous component and the elastic component can be expressed by a phase difference. In the case of a pure viscous material, the phase difference is 90 degrees. On the other hand, in the case of a pure elastic body, the phase difference is 0 degree. Thus, in the function of adhesion, it is important to adjust the hardness and softness (complex elastic modulus) of the adhesive and the viscosity / elasticity balance (phase difference) of the adhesive.

  Viscosity and elasticity can be measured by static measurement methods such as a creep test (so-called holding force test), or by changing the speed of deformation (frequency-dependent) when applying deformation to a measurement substance called oscillation. There is a typical measurement method. Considering the fact that it is actually applied to the skin, the dynamic test method in which the speed of deformation changes can observe a phenomenon closer to actual use. Therefore, this measurement method is employed in the present invention.

  In the present invention, the complex elastic modulus and the phase difference are measured in a frequency band (deformation speed) that seems to be suitable for sticking of a human body, that is, in a low frequency range, a high frequency range, and an intermediate frequency range thereof. Viscoelasticity data has been obtained, using 0.1Hz as the low frequency range, 1Hz as the intermediate frequency range, and 10Hz as the high frequency range. The relationship between frequency and adhesion behavior is considered as follows. The complex elastic modulus and phase difference in the measurement in the low frequency range are related to the process of minute deformation at a low speed such as adhesion (wetting) of the adherent to the adherend and creep behavior (plastic deformation). When it is hard in the low frequency range (complex elastic modulus is too high) or there are many elastic components (the phase difference is too low), good deformation at low speed cannot be achieved and wettability is not good. However, if it is too soft (complex elastic modulus is too low) or there are too many viscous components (phase difference is too high), the cohesiveness will be reduced, and after cold flow (deformation or sag during storage) or water absorption This causes problems such as a decrease in shape retention. The complex elastic modulus and phase difference in the measurement in the high frequency range are related to high-speed deformation processes such as tack and peeling behavior. If it is hard in the high frequency range (complex elastic modulus is too high) or has a lot of elastic components (the phase difference is too low), good deformation at high speed cannot be achieved and sufficient tack cannot be obtained, or during peeling Excessive stress may be applied to the adherend. Conversely, if it is too soft (complex elastic modulus is too low) or there are too many viscous components (phase difference is too high), problems such as adhesive residue on the skin at the time of peeling occur. Furthermore, the complex elastic modulus and phase difference measured as an intermediate region between the low frequency and the high frequency are considered to affect the followability to the skin being applied. In other words, unless it is designed so as to have an appropriate complex elastic modulus and phase difference, it cannot respond to the elasticity of the skin itself, that is, the movement of the skin due to the extension of the skin or the like, and uncomfortable feeling occurs during the application.

  The value of the complex elastic modulus and phase difference measured at 37 ° C. of the present invention is preferably a complex elastic modulus of 10,000 to 80,000 Pa and a phase difference of 10 ° to 40 ° at a frequency of 0.1 Hz, and a complex elastic modulus of 15000 to 40,000 Pa and a phase difference of 20 More preferably, the angle is 35 °. If the complex elastic modulus is less than 10000 Pa and the phase difference is greater than 40 °, the cohesiveness is reduced, and cold flow (deformation and sag during storage) and shape retention after water absorption are likely to decrease, while the complex elastic modulus is 80000 Pa. If it is larger and the phase difference is smaller than 10 °, the wettability decreases. Further, when the frequency is 1.0 Hz, a phase difference of 20 ° to 55 ° is preferable when the complex elastic modulus is 20000 to 130,000 Pa, and a phase difference of 25 ° to 50 ° is more preferable when the complex elastic modulus is 2500 to 100000 Pa. If the complex elastic modulus is less than 20000 Pa and the phase difference is greater than 55 °, displacement and deformation from the application position when the exudate is absorbed are likely to occur, while the complex elastic modulus is greater than 130,000 Pa and the phase difference is less than 20 °. Inability to respond to skin movement due to extension, etc., and uncomfortable feeling occurs during application. Furthermore, when the frequency is 10.0 Hz, a phase difference of 25 ° to 50 ° is preferable at a complex elastic modulus of 60000 to 500000 Pa, and a phase difference of 30 ° to 45 ° is more preferable at a complex elastic modulus of 100000 to 400000 Pa. If the complex elastic modulus is smaller than 60000 Pa and the phase difference is larger than 50 °, the monolithic retention of hydrocolloid after water absorption decreases, and adhesive residue and hydrocolloid collapse easily occur at the time of peeling, while the complex elastic modulus is larger than 500000 Pa. When the phase difference is less than 25 °, it is difficult to obtain a good tack at the time of application, and excessive stress is easily applied to the application site at the time of peeling.

  In the present invention, a preferred blend of hydrocolloids exhibiting the above physical properties is a blend composed of a thermoplastic elastomer, a liquid rubber compatible with the thermoplastic elastomer, and a water-soluble and / or water-insoluble hydrophilic substance. Also add other materials such as antioxidants, cohesive strength reinforcements, plasticizers, tackifiers, wound healing agents, antibacterial agents, bactericides, deodorants to change properties for specific uses Can do. However, in the present invention, even if these other materials are added, it is preferable that they are blended so as not to depart from the ranges of the complex elastic modulus and phase difference defined by the present invention.

  As the thermoplastic elastomer, a styrene copolymer can be used, such as a styrene-isoprene-styrene block copolymer (SIS), a styrene-butadiene-styrene block copolymer (SBS), and a styrene-ethylene / propylene-styrene block copolymer. Polymer (SEPS), styrene-ethylene / butylene-styrene block copolymer (SEBS), styrene-ethylene / ethylene / propylene-styrene block copolymer (SEEPS), hydrogenated styrene-butadiene rubber (HSBR), styrene- An ethylene / butylene-olefin crystal block copolymer (SEBC), an olefin crystal-ethylene / butylene-olefin crystal block copolymer (CEBC), a urethane copolymer, and an acrylic copolymer are preferable. Further, it is preferable to select a viscosity average molecular weight in the range of 100,000 to 500,000, which imparts elastic properties to the hydrocolloid.

  Liquid rubbers compatible with thermoplastic elastomers include liquid isoprene rubber (LIR) with a viscosity average molecular weight of 29,000 to 50,000, liquid styrene-isoprene rubber (LSIR) with a viscosity average molecular weight of 30,000 to 50,000, and a liquid with a viscosity average molecular weight of 20,000 to 40,000. Preferred are ethylene / propylene rubber (LEPR), liquid styrene-ethylene / propylene rubber (LSEPR) having a viscosity average molecular weight of 10,000 to 30,000, liquid polyisobutylene having a viscosity average molecular weight of 30,000 to 100,000, and liquid polybutene having a viscosity average molecular weight of 200 to 5,000. This liquid rubber lowers the elasticity of the thermoplastic elastomer to give flexibility and also increases the tackiness. From the viewpoint of compatibility, the combination of thermoplastic elastomer and liquid rubber is preferably LIR and / or LSIR for SIS, liquid butadiene rubber for SBS, LEPR and / or LSEPR and HSBR for SEPS. For example, a combination of LEPR, LSEPR, liquid polyisobutylene, liquid polybutene, or a liquid rubber made of a mixture thereof.

  By making such a compatible combination, even when the blending ratio of the liquid rubber is increased, that is, when flexibility is to be increased, bleeding of the liquid rubber and adhesive residue at the time of peeling can be prevented. Further, among these combinations, a combination of SEPS and LEPR and / or LSEPR is particularly preferable. This is because SEPS, LEPR, and LSEPR do not contain a double bond, and thus have higher stability to heat and light than SIS, and have an appropriate viscosity, and thus can exhibit good adhesion even after water absorption. . Further, the liquid rubber may be a cross-linked one, and it is effective to mix it appropriately for the purpose of improving the cohesiveness. The weight ratio of the thermoplastic elastomer and the liquid rubber having good compatibility with the thermoplastic elastomer is in the range of 1: 2 to 1: 6, and the mixture of the thermoplastic elastomer and the liquid elastomer having good compatibility with the thermoplastic elastomer. The viscosity average molecular weight is preferably in the range of 30000-200000, and more preferably in the range of 30000-100,000.

  As the water-soluble and / or water-insoluble hydrophilic substance, those conventionally used can be used singly or in combination. Due to the presence of the hydrophilic substance, the hydrocolloid can absorb sweat and leachate. Preferable hydrophilic substances are pectin, carboxymethylcellulose sodium (CMC-Na), guar gum, gelatin, karaya gum, alginic acid, chitin, chitosan, polyvinyl alcohol, polyacrylate, starch / acrylic acid graft polymer. The hydrophilic substance is preferably contained in an amount of 10 to 60% by weight based on the total weight of the hydrocolloid.

  Furthermore, it is also effective to add various substances for the purpose of changing properties for a specific use. For example, mineral oil such as liquid paraffin and petrolatum can be added for the purpose of softening the thermoplastic elastomer, or butyl rubber having a molecular weight in the range of 300,000 to 500,000 can be added in order to increase the tackiness. In addition, a medicinal component for the purpose of skin treatment or prevention of damage, beauty and the like can be added to skin that has already been damaged or is expected to be damaged. For example, for skin that has been damaged due to repeated exfoliation, by adding a substance with a moisturizing effect such as ceramide, it is effective in cooperation with the characteristics of the hydrocoid material with less peeling irritation of the present invention. Can be close to healthy skin. In addition, when applying the hydrocolloid material of the present invention to the site where the occurrence of pressure ulcers is concerned, by adding γ oryzanol or the like with a high blood flow promoting effect, alleviation of the occlusion of blood vessels caused by body pressure, Anti-decubitus can be expected.

  The patch using the hydrocolloid material of the present invention can be formed into a shape suitable for the application site of the skin. However, in order to improve the handleability, the hydrocolloid material is formed into a sheet and supported on one side. It is preferable to provide a layer. As the support layer, a processed polymer compound can be used. Examples of the polymer compound include polyolefin (polyethylene, polypropylene, and modified products thereof), olefin copolymer (ethylene-vinyl acetate copolymer, ethylene-ethyl (meth) acrylate copolymer, ethylene-methyl (meta ) Acrylate copolymer and ethylene- (meth) acrylic acid copolymer), polyurethane, polyester, polyacrylic acid, polyamide, polyvinyl chloride, polyvinylidene chloride, polystyrene, fluororesin, silicone resin, cellulose, natural fiber ( Cotton, wool, hemp and silk) and chemical fibers (viscose rayon, cupra rayon, polynosic, acetate, triacetate, polyethylene, polypropylene, polyamide, polyester, polyacrylonitrile, vinylon, polyvinyl chloride, vinyl Isopropylidene and polyurethane, etc.) and the like. Of these, preferred are polyolefin, polyurethane, polyester and polyacrylic acid, and particularly preferred is polyurethane. Examples of the shape of the support include a film, foam (sponge), nonwoven fabric, woven fabric, and knitted fabric. Of these, films and foams are preferable, and films are more preferable. In particular, a polyurethane film is preferred from the viewpoints of flexibility, stretchability, moderate water vapor permeability, and fungus barrier properties.

  According to the present invention, by giving the hydrocolloid material a specific complex elastic modulus and phase difference, it has good adhesiveness to the affected area to be applied and responsiveness to skin extension, and sweat and Sufficient absorbability with respect to the exudate and shape retention after absorption are maintained, and at the time of peeling, the composition does not remain on the affected area and can be peeled without damaging the skin or wound surface. Further, the hydrocolloid material of the present invention does not particularly require the presence of a material that easily bleeds or a material that easily irritates the skin, and can be composed of a small number of materials, so that it is easy to manufacture and is economically advantageous.

  Examples of the present invention and evaluation results thereof will be described below.

  Example 1: 18.2 parts by weight of S1S as a thermoplastic elastomer (molecular weight of about 170,000 manufactured by Enychem), 42.3 parts by weight of LIR (molecular weight of about 29000, manufactured by Kuraray Co., Ltd.) as a liquid rubber having good compatibility with the thermoplastic elastomer, and polyisobutylene Charge 27.8 parts by weight (manufactured by Nippon Petrochemical Co., Ltd.) and 11.9 parts by weight of butyl rubber (manufactured by Exxon) into a pressure kneader and mix until uniform. Next, 33.3 parts by weight of CMC-Na (manufactured by Daicel) was added as a hydrophilic substance and mixed under pressure until uniform, thereby preparing an adhesive composition.

  Examples 2 to 7 are examples of the present invention blended with different components using the same method as in Example 1. Examples 8 and 9 are the addition of ceramide and γ oryzanol to the hydrocolloid material of Example 7, respectively. FIG. 1 shows a list of the formulations.

  The hydrocolloid composition obtained by the above blending was rolled to a thickness of 600 μm to prepare a specimen of a hydrocolloid patch using a 15 μm polyurethane film as a support layer. Using this specimen as a target, viscoelasticity, water absorption, adhesive properties (initial adhesive strength, sealability), skin adhesion test, and exfoliation property were verified. Each test method will be described below.

  Viscoelasticity: Three test pieces with a diameter of 20 mm are prepared from the specimen (however, only the specimen used for this measurement is the one before the polyurethane film of the support layer is attached). Using a rotary rheometer (trade name “Rheostress RS150” manufactured by HAAKE) in an environment with a relative humidity of 20% and a temperature of 20 ° C., the measurement temperature is 37 degrees, the shear stress is 100 Pa, and the frequency range is 0.03 to 46 Hz. Oscillation was measured, and the complex elastic modulus and phase difference were measured at frequencies of 0.1 Hz, 1.0 Hz, and 10.0 Hz.

  Water absorption: Make 3 specimens with a diameter of 30mm from the specimen. Immerse in physiological saline (0.9% NaCl solution) at 37 ° C. The weight of the test piece is measured at 3 hours, 6 hours, 24 hours and 48 hours after immersion to determine the water absorption and water absorption.

Adhesive properties:
a) Initial adhesive strength (conforms to JIS T9233 Mitsuhashi method): Create three test specimens with a width of 15 to 25 mm and a length of 100 mm from the specimen. Clean the surface of the bonded disc (diameter 50 mm, thickness 14 mm, aluminum) with an organic solvent and dry. The adhesive disk is brought into contact with the fixed test piece adhesive surface at 4.90 N (500 gf) for 2 seconds and pulled up at a speed of 30 mm / min. Measure the adhesive strength when the bonded disk and test piece are separated.
b) Sealing property (initial adhesive strength at the time of water absorption): Prepare three test pieces with a diameter of 30 mm from the specimen. Immerse in physiological saline solution (0.9% NaCl solution) at 37 ° C. After water absorption of 100 to 200%, the sealing property is measured by the initial adhesive strength test method.

  Skin sticking test (repeated sticking test): Prepare a test piece 25 mm wide and 50 mm long from the specimen. A test piece is attached to the inner side of the upper arm of two subjects. Change the specimen every 24 hours and repeat three times. At the time of exchanging the test piece, the area of the peeled (turned) portion of the test piece is measured, and the peel rate is calculated from the area of the entire test piece. Also, the peel force is measured using a push-pull gauge when the test piece is peeled off.

  Exfoliation: Use the specimen after peeling used in the skin patch test. Cut out 15mm width and 20mm length from the center of the test piece, fix it in formalin, and then stain the keratin with eosin solution. Then, it is washed with an ethanol solution and observed with a microscope at a magnification of 100 to evaluate the amount of exfoliated keratin. Also, the stratum corneum peeling area is calculated by image analysis software.

  Each test result by said measuring method is as showing in FIGS. In addition, as a comparison of the characteristics of the present invention, the conventional hydrocolloid patch was compared with Comparative Example 1 (“Duoactive ET” manufactured by Convatec) and Comparative Example 2 (“Tegassorbite” manufactured by 3M) and verified together. did.

  FIG. 2 shows the measurement results of viscoelasticity (complex elastic modulus / phase difference). In FIG. 2, in Example 8, it is considered that the complex elastic modulus at a frequency of 0.1 [Hz] is higher than that of the other examples due to the influence of ceramide. Thus, the hydrocolloid material can be provided with suitable physical properties as described later.

  Next, FIG. 3 showing the water absorption test results will be described. As can be seen from FIG. 3, the water-absorbing performance can be controlled by selecting a hydrophilic substance and its blending amount. Example 2 is a low water-absorbing material that can cope with sweating and can be used for application to healthy skin. In addition, other embodiments are highly water-absorbing and can be applied to sites with a relatively large amount of exudate such as wounds and around the colostomy.

  Next, FIG. 4 showing the test result of the adhesive property will be described. As can be seen from FIG. 4, in Examples 5 to 9, since SEPS and HSBR having higher viscosity than SIS are used, it can be seen that good sealing properties (adhesiveness during water absorption) are exhibited.

  Next, according to FIG. 5 of the test results of the skin patch test (repeated patch test), none of the examples had any adhesive residue on the skin. Further, in the second and subsequent peeling, the comparative example has a tendency to increase the peeling force, but the example showed a substantially constant value. Since the stratum corneum has a stronger binding force toward the inside of the skin, such an increase in peeling force is considered to mean that the stratum corneum is peeled off every time the test piece is peeled off.

  FIG. 6 shows the results of measuring the keratin exfoliation area with image analysis software in the keratin exfoliation test. According to the test results, the stratum corneum peeled off by the test piece is dyed dark red. In the first peeling, all the test pieces of Examples and Comparative Examples were stained red, but the degree of staining was lower in the Examples. However, the exfoliated exfoliation is exfoliant (so-called plaque) that is not so much involved in the barrier function of the skin, and it is considered that there is almost no damage to the skin. In exfoliation after the second time, all of the test pieces of the comparative examples are stained red and a lot of keratin is peeled off, whereas the test pieces of the examples are hardly dyed and only a few keratins are peeled off. It was confirmed.

  FIG. 7 is a side view of an embodiment of the patch of the present invention. Reference numeral 1 denotes a hydrocolloid layer formed in a film shape, 2 a support layer provided on one surface thereof, and 3 a release material disposed on the other surface. The support layer 2 retains the shape of the hydrocolloid layer 1 and has a function of facilitating handling, and protects the surface of the hydrocolloid layer 1. In use, after removing the release material 3, when the exposed surface of the hydrocolloid layer 1 is pasted on the skin or ulcer to be applied, the hydrocolloid layer 1 is adhered onto the application site with its adhesiveness. The

The figure which shows the list of the mixing | blending of the hydrocolloid material which concerns on the Example of this invention. The figure which shows the measurement result of the viscoelasticity (complex elastic modulus and phase difference) of an Example with a comparative example. The figure which shows the measurement result of the water absorption (amount of water absorption / water absorption rate) of an Example with a comparative example. The figure which shows the measurement result of the adhesion characteristic of an Example with a comparative example. The figure which shows the skin sticking test result of an Example with a comparative example. The figure which shows the measurement result of the exfoliation property of an Example with a comparative example. The side view of the Example of the adhesive material of this invention.

Explanation of symbols

1 Hydrocolloid layer 2 Support layer 3 Release material

Claims (13)

Adhesive hydrocolloid material applied to the skin surface, complex elastic modulus and phase difference measured at 37 ° C, when the frequency is 0.1Hz, the phase difference is 10 ° to 40 ° Pa and the phase difference is 10 ° to 40,000Pa, the frequency A hydrocolloid material having a complex elastic modulus of 20000 to 130,000 Pa and a phase difference of 20 ° to 55 ° at 1.0 Hz, and a complex elastic modulus of 60000 to 500000 Pa and a phase difference of 25 ° to 50 ° at a frequency of 10.0 Hz. 2. The hydrocolloid material according to claim 1, comprising a thermoplastic elastomer, a liquid rubber compatible with the thermoplastic elastomer, and a water-soluble and / or water-insoluble hydrophilic substance. The hydrocolloid material according to claim 2, wherein the water-soluble and / or water-insoluble hydrophilic substance is contained in an amount of 10 to 60% by weight. The hydrocolloid material according to claim 2 or 3, wherein the weight ratio of the thermoplastic elastomer and the liquid rubber compatible with the thermoplastic elastomer is 1: 2 to 1: 6. The thermoplastic elastomer is a styrene-isoprene-styrene block copolymer, and the liquid rubber compatible with the thermoplastic elastomer is liquid isoprene rubber and / or liquid styrene-isoprene rubber. The hydrocolloid material according to any one of the above. The thermoplastic elastomer is a styrene-ethylene / propylene-styrene block copolymer, and the liquid rubber compatible with the thermoplastic elastomer is liquid ethylene / propylene rubber and / or liquid styrene-ethylene / propylene rubber. The hydrocolloid material according to any one of claims 2 to 4. The thermoplastic elastomer is hydrogenated styrene-butadiene rubber, and the liquid rubber compatible with the thermoplastic elastomer is any one of liquid ethylene / propylene rubber, liquid styrene-ethylene / propylene rubber, liquid polyisobutylene, liquid polybutene, or It consists of these mixtures, The hydrocolloid material of any one of Claims 2-4 characterized by the above-mentioned. The hydrocolloid material according to any one of claims 2 to 7, wherein the liquid rubber is crosslinked. The hydrocolloid material according to any one of claims 2 to 8, wherein the viscosity average molecular weight of the mixture of the thermoplastic elastomer and the liquid rubber compatible with the thermoplastic elastomer is 30,000 to 200,000. Styrene-isoprene-styrene block copolymer, styrene-butadiene-styrene block copolymer, styrene-ethylene / propylene-styrene block copolymer, styrene-ethylene / butylene-styrene block copolymer, styrene-ethylene / ethylene / One of propylene-styrene block copolymer, hydrogenated styrene-butadiene rubber, styrene-ethylene / butylene-olefin crystal block copolymer, olefin crystal-ethylene / butylene-olefin crystal block copolymer, or these Thermoplastic elastomer composed of a mixture, liquid isoprene rubber, liquid styrene-isoprene rubber, liquid ethylene / propylene rubber, liquid styrene-ethylene / propylene rubber, liquid polyisobutylene, liquid polybutene, or a mixture thereof In a hydrocolloid material containing a liquid elastomer compatible with a thermoplastic elastomer composed of a product and a water-soluble and / or water-insoluble hydrophilic substance, the weight ratio of the thermoplastic elastomer and the liquid rubber compatible with the thermoplastic elastomer is 1: 2 to 1: 6, and the viscosity average molecular weight of the thermoplastic elastomer and the liquid rubber mixture compatible with the thermoplastic elastomer is 30000 to 200000, and the complex elastic modulus and retardation value measured at 37 ° C. When the frequency is 0.1 Hz, the phase difference is 10 ° to 40 ° at a complex elastic modulus of 10000 to 80000 Pa, when the frequency is 1.0 Hz, the phase difference is 20 ° to 130,000 Pa, the phase difference is 20 ° to 55 °, and the frequency is 10.0 Hz. An adhesive hydrocolloid material applied to the skin surface, characterized by a phase difference of 25 ° to 50 ° at ˜500000 Pa. The hydrocolloid material according to any one of claims 1 to 10, wherein a medicinal component is added. A patch, wherein the hydrocolloid material according to any one of claims 1 to 11 is used. The patch according to claim 12, wherein a support layer is provided on one surface of the sheet-like hydrocolloid material, and a release material is provided on the other surface.

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