JP2004231621A - Preparation for external use - Google Patents
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- JP2004231621A JP2004231621A JP2003025353A JP2003025353A JP2004231621A JP 2004231621 A JP2004231621 A JP 2004231621A JP 2003025353 A JP2003025353 A JP 2003025353A JP 2003025353 A JP2003025353 A JP 2003025353A JP 2004231621 A JP2004231621 A JP 2004231621A
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- polyhydric alcohol
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Landscapes
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Abstract
Description
【０００１】
【発明の属する技術分野】
本発明は、一般式１に示される化合物および／またはその塩類を含有することを特徴とする外用剤に関するものである。より詳しくは、多価アルコールおよび金属イオン封鎖剤を配合することにより、保存安定性の向上した一般式１に示される化合物および／またはその塩類を配合した外用剤に関わるものである。
【０００２】
【従来の技術】
一般式１に示される化合物および／またはその塩類は単体では安定ながら、生体に適用されたときには活性型へと代謝され、抗酸化能、血行促進作用、ラジカルスカベンジャー作用、抗炎症作用等の薬理活性を発揮し、今後もその利用価値は高まると思われる。これまで、一般式１に示される化合物および／またはその塩類を安定に配合する方法としては、特許文献１や２の特許があるが、今回特に、多価アルコールおよび金属イオン封鎖剤を併用することにより外用剤の安定性をより向上させることが判明した。
【０００３】
【特許文献１】
特公平３−３２５５８
【特許文献２】
特開平１１−１９９４２４
【０００４】
またヒトに対し使用する製剤、例えば化粧品、医薬部外品、医薬品等に関しては、市場流通において経時的、対温度的な安定性に優れていることが求められる。
【０００５】
【発明が解決しようとする課題】
この様な状況の中で、一般式１に示される化合物および／またはその塩類は、水等に分散すると、自己会合体を形成したりすることから、溶解時に粘性を生ずる場合があり、製造上の弊害になったり、外用剤中への配合は短期間であれば問題はないが、市場流通条件・期間において安定に配合することは従来の技術では成分の分解、析出、不溶化等が起こり困難であった。特許文献２はこれらの問題を解決すべく発明されたものであるが、本発明はより高い安定性を備えた外用剤を提供することを目的とする。
【０００６】
【課題を解決するための手段】
本発明者らは、これらの課題に対し解決すべく手段を検討した結果、一般式１に示される化合物および／またはその塩類を外用剤に配合するに当たり、多価アルコールと金属イオン封鎖剤を適当量併用することにより非常に高い安定性を有する外用剤を得ることを発見し、本発明を完成した。また、外用剤の調製時においてこれらの多価アルコールに一般式１に示される化合物および／またはその塩類を溶解すると、単独では継粉になりやすいが、比較的容易に水中に溶解させることが可能となることは外用剤を製造する上で都合のよいことである。また、一般式１に示される化合物および／またはその塩類を溶解する多価アルコールとしては、グリセリンを用いると、水への溶解性がすこぶる速やかになることを見出した。
以上述べたとおり、われわれは一般式１に示される化合物および／またはその塩類を配合した外用剤について、市場流通における安定性を確保する方法を見いだし、本発明を完成するに到った。
【０００７】
すなわち、一般式１に示される化合物および／またはその塩類と多価アルコールおよび金属イオン封鎖剤を適当量併用することにより、経時的、対温度的な安定性を有する外用剤の提供を可能としたものである。
【０００８】
以下、本発明の構成について詳述する。
【０００９】
本発明で用いられる一般式１の物質はクロマン骨格を持ち、肌あれに対し非常に有効な防御効果を持つ化合物である。これらの化合物は、生体に使用するとき、抗酸化能力に優れ、生体内における活性酸素、それに由来する過酸化脂質やフリーラジカルの弊害を予防したり、抗炎症作用や血行促進を代表とする生理活性作用を示し、ヒト皮膚における色素沈着を予防・改善したり、育毛・発毛効果を発揮したりし、例えばビタミンやその誘導体と共存することにより相乗効果的にお互いの有効性を向上させることができる。
【００１０】
具体的にはＲ１，Ｒ２はそれぞれ水素、アルキル基、アシル基、酸化エチレン、アルカリ金属、アルカリ土類金属等のひとつ以上から選ばれ、必要に応じて組み合わせてもよい。これらの選択により溶解性、ゲル形成性、自己会合性等の物性を変化させることができる。
【００１１】
本発明で用いられる一般式１に示される化合物は、好ましくは、Ｒ１，Ｒ２の少なくともひとつがナトリウムまたはカリウムである。さらに含有量は、特に限定されるものではないが０．１〜２５重量％とすることが好ましく、０．１重量％未満では生理活性を発揮するのに充分でない場合があり、２５重量％を超えて含有することは可能であるが外用剤として経済性、使用性の面から好ましくない。
【００１２】
また、本発明における多価アルコールの役割は非常に大きいものがある。これまで多価アルコールのひとつであるグリセリンは、一般式１に示される化合物および／またはその塩類が、ゲルを形成したり水中油（Ｏ／Ｗ）型組成物を形成したりする能力を補助することが知られていた。
今回われわれはこのような界面科学的な挙動とは別に、一般式１に示される化合物および／またはその塩類と多価アルコールおよび金属イオン封鎖剤を併用することで、一般式１に示される化合物および／またはその塩類を配合した外用剤の経時的、温度的な安定性が向上することを見出した。
【００１３】
本発明で用いられる多価アルコールの種類は特に限定されないが、例えばグリセリン、ジグリセリン、ポリグリセリン、エチレングリコール、ジエチレングリコール、トリエチレングリコール、ポリエチレングリコール、プロピレングリコール、ジプロピレングリコール、ポリプロピレングリコール、イソプレングリコール、１，３−ブチレングリコール、１，２−ペンタンジオール、１，５−ペンタンジオール等が挙げられ、特にグリセリン、プロピレングリコール、１，３−ブチレングリコールが好ましい。
【００１４】
本発明で用いられる多価アルコールの配合量は特に限定されないが、一般式１に示される化合物および／またはその塩類の配合量に対し、重量比で１〜５００倍、さらに好ましくは２〜２０倍である。その配合量が１倍未満では充分な効果が得られず、５００倍を超えて配合することは可能であるが、使用感触の面でべとつきを感じ、デメリットとなる場合がある。
【００１５】
本発明で用いられる金属イオン封鎖剤は特に限定されないが、エデト酸およびその塩類、アラニン、エチレンジアミンヒドロキシエチル三酢酸三ナトリウム、クエン酸ナトリウム、グルコン酸、酒石酸、フィチン酸、ポリリン酸ナトリウム、メタリン酸ナトリウム、ヒドロキシエタンジホスフォン酸およびその塩類であり、好ましくはエデト酸のナトリウム塩である。
【００１６】
本発明で用いられる金属イオン封鎖剤の配合量は特に限定されないが０．０１〜３．０重量％が好ましく、さらに好ましくは０．０５〜１．０重量％である。その配合量が０．０１重量％未満では充分な効果が得られず、３．０重量％を超えて配合することは可能であるが、経済的、安定性の観点から、デメリットとなる場合がある。
【００１７】
外用剤の調製においては、一般式１に示される化合物および／またはその塩類を多価アルコールと良く混合し、場合によっては加熱溶解し、配合するのが簡便であり、調製時間も短縮されるが、調製方法に関わらず、本発明により安定性は向上する。
【００１８】
本発明の組成物は上記必須成分の他に、通常の外用剤に用いられる化粧料、医薬部外品、医薬品等の各種成分、さらに食品に用いられる成分を配合することができる。例えば油性成分、脂質、保湿剤、増粘剤、薬効成分、殺菌・防腐剤、顔料、粉体、ｐＨ調整剤、紫外線吸収剤、抗酸化剤、可塑剤、香料、アミノ酸、甘味料、着色料等を適宜配合することができる。さらにゲル形成能や乳化能を補助する役割で他の界面活性剤も配合することができる。
【００１９】
具体的には油性成分としては、例えば炭化水素、植物由来油、昆虫由来油、動物油脂、トリグリセライド、高級アルコール、脂肪酸、高級アルコールと脂肪酸のエステル、シリコーン油等が挙げられる。保湿剤としては、例えば多価アルコール、高分子多糖類、植物抽出エキス、微生物の代謝物などが挙げられる。増粘剤としては、例えばカルボキシビニルポリマー、キサンタンガム、メチルセルロース、ポリビニルピロリドン、ゼラチン、ベントナイト等の粘土鉱物等が挙げられる。薬効成分としては、例えば各種ビタミンおよびその誘導体、アラントイン、グリチルリチン酸およびその誘導体、各種動植物抽出物等が挙げられる。さらに乳化剤としては、例えばポリオキシエチレンアルキルエーテル、ポリオキシエチレン脂肪酸エステル、ポリオキシエチレンソルビタン脂肪酸エステル、ソルビタン脂肪酸エステル、グリセリン脂肪酸エステル、ポリグリセリン脂肪酸エステル、ポリオキシエチレン硬化ヒマシ油等の非イオン界面活性剤、ステアロイル乳酸ナトリウム等のアニオン界面活性剤、リン脂質等の両性界面活性剤、塩化アルキルトリメチルアンモニウム等のカチオン界面活性剤が挙げられる。
【００２０】
本発明の外用剤は公知の方法により製造することができ、化粧料、医薬部外品、医薬品等の分野を問わず利用できるものであり、その剤型は目的に応じて任意に選択でき、クリーム、乳液、ローション、ゲル、軟膏、パック、スティック等の形態とすることができる。
【００２１】
【発明の効果】
本発明の外用剤は、一般式１に示される化合物および／またはその塩類を含有するものであり、単独で配合されたものに比較して、多価アルコール及び金属イオン封鎖剤を配合することにより安定性がより向上した外用剤を得られるものである。
【００２２】
これらの効果を実証するために実施例１〜７を常法により調製し、評価した。表中の配合量は重量％を示し、精製水にて１００％に調整した。安定性の評価については、長期保存安定性（２５℃）、耐温度性（高温部：４０℃、５０℃、６０℃ 低温部：５℃、−２０℃）、耐光性（可視光及び近紫外線照射）について実施した。
【００２３】
【表１】実施例１ ローション１
（結果）
実施例１において得られたローション１は透明性に優れ、良好な安定性を示した。これに対し、比較例１においては概ね良好な安定性を示すものの、耐温度性試験（高温部）において若干の着色が認められた。
【００２５】
【表２】実施例２ ローション２
（結果）
実施例２において得られたローション２は透明性に優れ、良好な安定性を示した。これに対し、比較例２においては概ね良好な安定性を示すものの、耐温度性試験（高温部）において若干の着色が認められた。
【００２７】
【表３】実施例３ ローション３
（結果）
実施例３において得られたローション３は透明性に優れ、良好な安定性を示した。これに対し、比較例３においては概ね良好な安定性を示すものの、耐温度性試験（高温部）、耐光性試験において若干の着色が認められた。
【００２９】
【表４】実施例４ ローション４
（結果）
実施例４において得られたローション４は透明性に優れ、良好な安定性を示した。これに対し、比較例４においては、耐温度性試験（低温部）において析出物が観察された。
【００３１】
【表５】実施例５ ローション５
（結果）
実施例５において得られたローション５は透明性に優れ、良好な安定性を示した。これに対し、比較例５においては概ね良好な安定性を示すものの、耐温度性試験（高温部）、耐光性試験において若干の着色が認められた。
【００３３】
【表６】実施例６ ローション６
（結果）
実施例６において得られたローション６は透明性に優れ、良好な安定性を示した。これに対し、比較例６においては溶解に相当時間を要した上に、耐温度性試験（低温部）で保存中に不溶物の析出が観察された。また、耐温度性試験（高温部）において実施例６はほとんど着色が認められなかったが、比較例６では着色が観察された。
【００３５】
【表７】実施例７ ローション７
（比較例７の製造方法）
成分４，５を成分３に溶解し、成分６を溶解した成分７に添加する。この部分を撹拌しながら成分１を徐々に添加する。すべての成分を混合後、プロペラ撹拌機８００ｒｐｍで、全成分が完全に溶解するまで撹拌する。
【００３７】
（比較例８の製造方法）
成分４，５を成分３に溶解し、成分６を溶解した成分７に添加する。この部分に成分２を加え均一に溶解後、撹拌しながら成分１を徐々に添加する。すべての成分を混合後、プロペラ撹拌機８００ｒｐｍで、全成分が完全に溶解するまで撹拌する。
【００３８】
（実施例７の製造方法）
成分４，５を成分３に溶解し、成分６を溶解した成分７に添加する。この部分に成分１を完全に溶解した成分２を、撹拌しながら成分１を徐々に添加する。すべての成分を混合後、プロペラ撹拌機８００ｒｐｍでで、全成分が完全に溶解するまで撹拌する。
【００３９】
（結果）
比較例７はすべての成分が透明に溶解するまで数時間、比較例８は約１時間要した。これらの比較例に対し実施例７では添加直後より透明な外観を示し、明らかに調製時間の短縮が認められた。
【００４０】
【表８】実施例８ ゲル外用剤１
（実施例８の製造方法）
１〜４を均一に加熱分散し、撹拌しながら５を加えて目的のゲル状外用剤１を得る。
【００４２】
（結果）
実施例８において得られたゲル状外用剤１は透明ゲル状の外観を有し、良好な安定性を示した。
【００４３】
【表９】実施例９ ゲル外用剤２
（実施例９の製造方法）
１〜５を均一に加熱分散し、撹拌しながら６を添加し目的のゲル状外用剤２を得る。
【００４５】
（結果）
実施例９において得られたゲル状外用剤２は透明ゲル状の外観を有し、良好な安定性を示した。
【００４６】
【表１０】実施例１０ 乳剤１
（実施例１０の製造方法）
１〜４を均一に加熱分散し、撹拌しながら５を加熱溶解した６を添加し、ホモミキサー５０００回転／分で１０分間乳化後、撹拌しながら冷却し、目的の乳剤１を得る。
【００４８】
（結果）
実施例１０において得られた乳剤１は均一な乳化粒子を有し、良好な安定性を示した。
【００４９】
【表１１】実施例１１ 乳剤２
（実施例１１の製造方法）
１〜４を均一に加熱分散し、撹拌しながら５〜７を加熱溶解した８を添加し、ホモミキサー５０００回転／分で１０分間乳化後、撹拌しながら冷却し、目的の乳剤２を得る。
【００５１】
（結果）
実施例１１において得られた乳剤２は均一な乳化粒子を有し、良好な安定性を示した。
【００５２】
【表１２】実施例１２ 外用クリーム
（実施例１２の製造方法）
１〜４を均一に加熱分散し、撹拌しながら５〜１１を加熱溶解した１３を添加し、ホモミキサー５０００回転／分で１０分間乳化後１２を加え、撹拌しながら冷却し、目的の外用クリームを得る。
【００５４】
（結果）
実施例１２において得られた外用クリームは均一な乳化粒子を形成し、滑らかでつやのある外観を有し、良好な安定性を示した。[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to an external preparation containing the compound represented by the general formula 1 and / or a salt thereof. More specifically, the present invention relates to an external preparation containing a compound represented by the general formula 1 and / or a salt thereof having improved storage stability by blending a polyhydric alcohol and a sequestering agent.
[0002]
[Prior art]
The compound represented by the general formula 1 and / or a salt thereof is stable alone, but is metabolized to an active form when applied to a living body, and has pharmacological activities such as antioxidant ability, blood circulation promoting action, radical scavenger action, and anti-inflammatory action. It is expected that its utility value will increase in the future. Until now, as a method for stably compounding the compound represented by the general formula 1 and / or its salts, there are patents of Patent Documents 1 and 2, but especially in this case, a polyhydric alcohol and a sequestering agent are used in combination. It was found that the stability of the external preparation was further improved.
[0003]
[Patent Document 1]
Tokuhei 3-32558
[Patent Document 2]
JP-A-11-199424
[0004]
In addition, preparations used for humans, such as cosmetics, quasi-drugs, and pharmaceuticals, are required to have excellent temporal and temperature stability in market distribution.
[0005]
[Problems to be solved by the invention]
Under such circumstances, the compound represented by the general formula 1 and / or its salt may form a self-aggregate when dispersed in water or the like, so that the compound may become viscous upon dissolution, and the There is no problem if the compounding in the external preparation is short-term, but it is difficult to stably compound it in the market distribution conditions and period by the conventional technology because the decomposition, precipitation, insolubilization, etc. of the components occur. Met. Patent Document 2 has been invented to solve these problems, but the present invention aims to provide an external preparation having higher stability.
[0006]
[Means for Solving the Problems]
The present inventors have studied means to solve these problems, and as a result, when compounding the compound represented by the general formula 1 and / or its salts into an external preparation, a polyhydric alcohol and a sequestering agent are appropriately used. The present inventors have found that an external preparation having extremely high stability can be obtained by using a combination of these agents in an amount, and completed the present invention. When the compound represented by the general formula 1 and / or its salts are dissolved in these polyhydric alcohols at the time of preparation of the external preparation, they can be easily turned into flour by themselves, but can be relatively easily dissolved in water. This is convenient for producing an external preparation. In addition, it has been found that when glycerin is used as a polyhydric alcohol for dissolving the compound represented by the general formula 1 and / or salts thereof, the solubility in water is extremely rapid.
As described above, we have found a method for ensuring the stability in market distribution of an external preparation containing the compound represented by the general formula 1 and / or a salt thereof, and have completed the present invention.
[0007]
That is, by using a compound represented by the general formula 1 and / or salts thereof in combination with a polyhydric alcohol and a sequestering agent in appropriate amounts, it has become possible to provide an external preparation having stability over time and temperature. Things.
[0008]
Hereinafter, the configuration of the present invention will be described in detail.
[0009]
The substance of the general formula 1 used in the present invention is a compound having a chroman skeleton and having a very effective protective effect against rough skin. When used in a living body, these compounds have excellent antioxidant ability, prevent the adverse effects of active oxygen in the living body, lipid peroxides and free radicals derived therefrom, and exhibit physiological properties such as anti-inflammatory action and blood circulation promotion. Shows an active effect, prevents and improves pigmentation in human skin, and exhibits hair growth and hair growth effects, for example, synergistically improving each other's effectiveness by coexisting with vitamins and their derivatives. Can be.
[0010]
Specifically, R 1 and R 2 are each selected from one or more of hydrogen, an alkyl group, an acyl group, ethylene oxide, an alkali metal, an alkaline earth metal, and the like, and may be combined as necessary. By these selections, physical properties such as solubility, gel-forming property and self-association property can be changed.
[0011]
In the compound represented by the general formula 1 used in the present invention, preferably, at least one of R 1 and R 2 is sodium or potassium. Further, the content is not particularly limited, but is preferably 0.1 to 25% by weight. If the content is less than 0.1% by weight, it may not be sufficient to exert a physiological activity. Although it is possible to contain more than this, it is not preferable from the viewpoints of economy and use as an external preparation.
[0012]
The role of the polyhydric alcohol in the present invention is very large. Glycerin, one of the polyhydric alcohols to date, aids the ability of the compounds of general formula 1 and / or their salts to form gels and oil-in-water (O / W) compositions. It was known.
This time, apart from such interfacial science behavior, by using a compound represented by the general formula 1 and / or a salt thereof in combination with a polyhydric alcohol and a sequestering agent, the compound represented by the general formula 1 It has been found that the stability over time and temperature of an external preparation containing a salt thereof is improved.
[0013]
The type of polyhydric alcohol used in the present invention is not particularly limited, for example, glycerin, diglycerin, polyglycerin, ethylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol, propylene glycol, dipropylene glycol, polypropylene glycol, isoprene glycol, Examples thereof include 1,3-butylene glycol, 1,2-pentanediol, and 1,5-pentanediol, and glycerin, propylene glycol, and 1,3-butylene glycol are particularly preferable.
[0014]
The blending amount of the polyhydric alcohol used in the present invention is not particularly limited, but is preferably 1 to 500 times, more preferably 2 to 20 times by weight, the compounding amount of the compound represented by the general formula 1 and / or salts thereof. It is. If the compounding amount is less than 1 time, a sufficient effect cannot be obtained, and the compounding amount can be more than 500 times. However, there is a case where stickiness is felt in terms of feeling of use, which may be disadvantageous.
[0015]
Sequestering agents used in the present invention are not particularly limited, edetic acid and its salts, alanine, trisodium ethylenediamine hydroxyethyl triacetate, sodium citrate, gluconic acid, tartaric acid, phytic acid, sodium polyphosphate, sodium metaphosphate , Hydroxyethanediphosphonic acid and its salts, preferably the sodium salt of edetic acid.
[0016]
The amount of the sequestering agent used in the present invention is not particularly limited, but is preferably 0.01 to 3.0% by weight, more preferably 0.05 to 1.0% by weight. When the amount is less than 0.01% by weight, a sufficient effect cannot be obtained, and the amount can be more than 3.0% by weight. However, from the viewpoint of economy and stability, disadvantages may occur. is there.
[0017]
In the preparation of an external preparation, it is easy to mix the compound represented by the general formula 1 and / or its salt with a polyhydric alcohol, and optionally heat and dissolve the compound, and to shorten the preparation time. Regardless of the preparation method, the present invention improves the stability.
[0018]
The composition of the present invention may contain, in addition to the essential components described above, various components such as cosmetics, quasi-drugs, and pharmaceuticals used in ordinary external preparations, and components used in foods. For example, oily components, lipids, humectants, thickeners, medicinal components, disinfectants / preservatives, pigments, powders, pH adjusters, ultraviolet absorbers, antioxidants, plasticizers, flavors, amino acids, sweeteners, coloring agents Etc. can be appropriately compounded. Further, other surfactants can be added to assist the gel forming ability and the emulsifying ability.
[0019]
Specifically, examples of the oil component include hydrocarbons, plant-derived oils, insect-derived oils, animal fats and oils, triglycerides, higher alcohols, fatty acids, esters of higher alcohols and fatty acids, and silicone oils. Examples of the humectant include polyhydric alcohols, high molecular weight polysaccharides, plant extracts, and metabolites of microorganisms. Examples of the thickener include carboxyvinyl polymer, xanthan gum, methylcellulose, polyvinylpyrrolidone, gelatin, clay minerals such as bentonite, and the like. Examples of the medicinal component include various vitamins and derivatives thereof, allantoin, glycyrrhizic acid and derivatives thereof, and various animal and plant extracts. Further, examples of the emulsifier include nonionic surfactants such as polyoxyethylene alkyl ether, polyoxyethylene fatty acid ester, polyoxyethylene sorbitan fatty acid ester, sorbitan fatty acid ester, glycerin fatty acid ester, polyglycerin fatty acid ester, and polyoxyethylene hydrogenated castor oil. Agents, anionic surfactants such as sodium stearoyl lactate, amphoteric surfactants such as phospholipids, and cationic surfactants such as alkyltrimethylammonium chloride.
[0020]
The external preparation of the present invention can be produced by a known method and can be used regardless of the fields of cosmetics, quasi-drugs, pharmaceuticals, and the like, and the dosage form can be arbitrarily selected depending on the purpose, It can be in the form of a cream, emulsion, lotion, gel, ointment, pack, stick or the like.
[0021]
【The invention's effect】
The external preparation of the present invention contains the compound represented by the general formula 1 and / or a salt thereof, and is obtained by mixing a polyhydric alcohol and a sequestering agent as compared with a single compound. An external preparation having improved stability can be obtained.
[0022]
In order to demonstrate these effects, Examples 1 to 7 were prepared by a conventional method and evaluated. The blending amount in the table indicates% by weight, and was adjusted to 100% with purified water. Evaluation of stability includes long-term storage stability (25 ° C), temperature resistance (high-temperature part: 40 ° C, 50 ° C, 60 ° C low-temperature part: 5 ° C, -20 ° C), light resistance (visible light and near ultraviolet light) Irradiation).
[0023]
[Table 1] Example 1 Lotion 1
(result)
Lotion 1 obtained in Example 1 was excellent in transparency and showed good stability. In contrast, Comparative Example 1 showed generally good stability, but slight coloring was observed in the temperature resistance test (high-temperature portion).
[0025]
[Table 2] Example 2 Lotion 2
(result)
Lotion 2 obtained in Example 2 was excellent in transparency and showed good stability. In contrast, Comparative Example 2 showed generally good stability, but slight coloring was observed in the temperature resistance test (high temperature part).
[0027]
[Table 3] Example 3 Lotion 3
(result)
The lotion 3 obtained in Example 3 was excellent in transparency and showed good stability. In contrast, Comparative Example 3 showed generally good stability, but slight coloring was observed in the temperature resistance test (high-temperature portion) and the light resistance test.
[0029]
[Table 4] Example 4 Lotion 4
(result)
Lotion 4 obtained in Example 4 was excellent in transparency and showed good stability. On the other hand, in Comparative Example 4, a precipitate was observed in the temperature resistance test (low temperature part).
[0031]
Table 5 Example 5 Lotion 5
(result)
The lotion 5 obtained in Example 5 was excellent in transparency and showed good stability. On the other hand, although comparative example 5 showed generally good stability, slight coloring was observed in the temperature resistance test (high temperature part) and the light resistance test.
[0033]
Table 6 Example 6 Lotion 6
(result)
The lotion 6 obtained in Example 6 was excellent in transparency and showed good stability. On the other hand, in Comparative Example 6, a considerable time was required for dissolution, and precipitation of insolubles was observed during storage in a temperature resistance test (low temperature part). Further, in the temperature resistance test (high-temperature portion), almost no coloring was observed in Example 6, but coloring was observed in Comparative Example 6.
[0035]
Table 7 Example 7 Lotion 7
(Production method of Comparative Example 7)
Components 4 and 5 are dissolved in component 3, and component 6 is added to dissolved component 7. Ingredient 1 is gradually added while stirring this portion. After mixing all components, stir with a propeller stirrer 800 rpm until all components are completely dissolved.
[0037]
(Production method of Comparative Example 8)
Components 4 and 5 are dissolved in component 3, and component 6 is added to dissolved component 7. After adding Component 2 to this portion and uniformly dissolving, Component 1 is gradually added with stirring. After mixing all components, stir with a propeller stirrer 800 rpm until all components are completely dissolved.
[0038]
(Production method of Example 7)
Components 4 and 5 are dissolved in component 3, and component 6 is added to dissolved component 7. Into this part, the component 2 in which the component 1 is completely dissolved is gradually added to the component 1 while stirring. After mixing all components, stir with a propeller stirrer at 800 rpm until all components are completely dissolved.
[0039]
(result)
Comparative Example 7 required several hours until all components were transparently dissolved, and Comparative Example 8 required about 1 hour. In contrast to these comparative examples, Example 7 showed a transparent appearance immediately after the addition, and clearly shortened the preparation time.
[0040]
Table 8 Example 8 Gel external preparation 1
(Production method of Example 8)
1 to 4 are uniformly heated and dispersed, and 5 is added with stirring to obtain the desired gel-like external preparation 1.
[0042]
(result)
The gel-like external preparation 1 obtained in Example 8 had a transparent gel-like appearance, and showed good stability.
[0043]
Example 9 Gel external preparation 2
(Production method of Example 9)
1 to 5 are uniformly heated and dispersed, and 6 is added with stirring to obtain the desired gel external preparation 2.
[0045]
(result)
The gel-like external preparation 2 obtained in Example 9 had a transparent gel-like appearance, and showed good stability.
[0046]
Table 10 Example 10 Emulsion 1
(Production method of Example 10)
1 to 4 are uniformly heated and dispersed, and 6 obtained by heating and dissolving 5 is added thereto with stirring, emulsified at 5,000 rpm for 10 minutes with a homomixer, and then cooled with stirring to obtain a desired emulsion 1.
[0048]
(result)
Emulsion 1 obtained in Example 10 had uniform emulsion particles and showed good stability.
[0049]
Table 11 Example 11 Emulsion 2
(Production method of Example 11)
1 to 4 are uniformly heated and dispersed, and 8 obtained by heating and dissolving 5 to 7 is added thereto with stirring, and emulsified at 5000 rpm for 10 minutes, followed by cooling with stirring to obtain a desired emulsion 2.
[0051]
(result)
Emulsion 2 obtained in Example 11 had uniform emulsion particles and showed good stability.
[0052]
Table 12 Example 12 Topical cream
(Production method of Example 12)
1 to 4 are uniformly heated and dispersed, and 13 obtained by heating and dissolving 5 to 11 is added thereto with stirring, followed by emulsification at a homomixer of 5,000 rpm for 10 minutes, followed by addition of 12, followed by cooling with stirring to obtain the desired external cream. Get.
[0054]
(result)
The topical cream obtained in Example 12 formed uniform emulsified particles, had a smooth and glossy appearance, and showed good stability.
Claims (11)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003025353A JP2004231621A (en) | 2003-02-03 | 2003-02-03 | Preparation for external use |
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003025353A JP2004231621A (en) | 2003-02-03 | 2003-02-03 | Preparation for external use |
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| Publication Number | Publication Date |
|---|---|
| JP2004231621A true JP2004231621A (en) | 2004-08-19 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2003025353A Pending JP2004231621A (en) | 2003-02-03 | 2003-02-03 | Preparation for external use |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP2004231621A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2182710A2 (en) | 2004-08-06 | 2010-05-05 | Fujitsu Limited | Terminal device, and message display method and program for the same |
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2003
- 2003-02-03 JP JP2003025353A patent/JP2004231621A/en active Pending
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2182710A2 (en) | 2004-08-06 | 2010-05-05 | Fujitsu Limited | Terminal device, and message display method and program for the same |
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