JP2004196728A - Emulsified composition of natural product origin - Google Patents
Emulsified composition of natural product origin Download PDFInfo
- Publication number
- JP2004196728A JP2004196728A JP2002369075A JP2002369075A JP2004196728A JP 2004196728 A JP2004196728 A JP 2004196728A JP 2002369075 A JP2002369075 A JP 2002369075A JP 2002369075 A JP2002369075 A JP 2002369075A JP 2004196728 A JP2004196728 A JP 2004196728A
- Authority
- JP
- Japan
- Prior art keywords
- weight
- alginic acid
- parts
- alginate
- emulsified composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 72
- 229930014626 natural product Natural products 0.000 title description 2
- 235000010443 alginic acid Nutrition 0.000 claims abstract description 48
- 229920000615 alginic acid Polymers 0.000 claims abstract description 48
- 229960001126 alginic acid Drugs 0.000 claims abstract description 39
- 239000000783 alginic acid Substances 0.000 claims abstract description 39
- 150000004781 alginic acids Chemical class 0.000 claims abstract description 37
- 150000005846 sugar alcohols Polymers 0.000 claims abstract description 24
- 150000002148 esters Chemical class 0.000 claims abstract description 22
- 150000003839 salts Chemical class 0.000 claims abstract description 21
- 238000002360 preparation method Methods 0.000 claims abstract description 14
- 235000010410 calcium alginate Nutrition 0.000 claims abstract description 3
- 239000000648 calcium alginate Substances 0.000 claims abstract description 3
- 229960002681 calcium alginate Drugs 0.000 claims abstract description 3
- OKHHGHGGPDJQHR-YMOPUZKJSA-L calcium;(2s,3s,4s,5s,6r)-6-[(2r,3s,4r,5s,6r)-2-carboxy-6-[(2r,3s,4r,5s,6r)-2-carboxylato-4,5,6-trihydroxyoxan-3-yl]oxy-4,5-dihydroxyoxan-3-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylate Chemical compound [Ca+2].O[C@@H]1[C@H](O)[C@H](O)O[C@@H](C([O-])=O)[C@H]1O[C@H]1[C@@H](O)[C@@H](O)[C@H](O[C@H]2[C@H]([C@@H](O)[C@H](O)[C@H](O2)C([O-])=O)O)[C@H](C(O)=O)O1 OKHHGHGGPDJQHR-YMOPUZKJSA-L 0.000 claims abstract description 3
- 239000000839 emulsion Substances 0.000 claims description 34
- HDSBZMRLPLPFLQ-UHFFFAOYSA-N Propylene glycol alginate Chemical compound OC1C(O)C(OC)OC(C(O)=O)C1OC1C(O)C(O)C(C)C(C(=O)OCC(C)O)O1 HDSBZMRLPLPFLQ-UHFFFAOYSA-N 0.000 claims description 15
- 235000010409 propane-1,2-diol alginate Nutrition 0.000 claims description 15
- 239000000770 propane-1,2-diol alginate Substances 0.000 claims description 15
- 229940072056 alginate Drugs 0.000 claims description 9
- 229910052751 metal Inorganic materials 0.000 claims description 9
- 239000002184 metal Substances 0.000 claims description 9
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 8
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 4
- 239000011777 magnesium Substances 0.000 claims description 4
- 229910052749 magnesium Inorganic materials 0.000 claims description 4
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 229910052782 aluminium Inorganic materials 0.000 claims description 3
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- -1 alginic acid propylene glycol ester Chemical class 0.000 abstract description 22
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 abstract description 13
- 235000010413 sodium alginate Nutrition 0.000 abstract description 13
- 239000000661 sodium alginate Substances 0.000 abstract description 13
- 229940005550 sodium alginate Drugs 0.000 abstract description 13
- 239000004094 surface-active agent Substances 0.000 abstract description 13
- DNIAPMSPPWPWGF-UHFFFAOYSA-N monopropylene glycol Natural products CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract description 10
- 229920001059 synthetic polymer Polymers 0.000 abstract description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 13
- 239000002537 cosmetic Substances 0.000 description 11
- FHKSXSQHXQEMOK-UHFFFAOYSA-N hexane-1,2-diol Chemical compound CCCCC(O)CO FHKSXSQHXQEMOK-UHFFFAOYSA-N 0.000 description 9
- UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 description 8
- 239000001110 calcium chloride Substances 0.000 description 8
- 229910001628 calcium chloride Inorganic materials 0.000 description 8
- 230000000694 effects Effects 0.000 description 6
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 6
- 229920000642 polymer Polymers 0.000 description 5
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 4
- 238000011161 development Methods 0.000 description 4
- 239000000843 powder Substances 0.000 description 4
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 3
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- 239000003945 anionic surfactant Substances 0.000 description 3
- 229910052791 calcium Inorganic materials 0.000 description 3
- 239000011575 calcium Substances 0.000 description 3
- 239000003814 drug Substances 0.000 description 3
- 230000001804 emulsifying effect Effects 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 230000001771 impaired effect Effects 0.000 description 3
- 230000006872 improvement Effects 0.000 description 3
- 239000002736 nonionic surfactant Substances 0.000 description 3
- 239000003921 oil Substances 0.000 description 3
- 235000019198 oils Nutrition 0.000 description 3
- WCVRQHFDJLLWFE-UHFFFAOYSA-N pentane-1,2-diol Chemical compound CCCC(O)CO WCVRQHFDJLLWFE-UHFFFAOYSA-N 0.000 description 3
- 238000003756 stirring Methods 0.000 description 3
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 2
- YYTSGNJTASLUOY-UHFFFAOYSA-N 1-chloropropan-2-ol Chemical compound CC(O)CCl YYTSGNJTASLUOY-UHFFFAOYSA-N 0.000 description 2
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N 2-Propenoic acid Natural products OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- LEEDMQGKBNGPDN-UHFFFAOYSA-N 2-methylnonadecane Chemical compound CCCCCCCCCCCCCCCCCC(C)C LEEDMQGKBNGPDN-UHFFFAOYSA-N 0.000 description 2
- XPFCZYUVICHKDS-UHFFFAOYSA-N 3-methylbutane-1,3-diol Chemical compound CC(C)(O)CCO XPFCZYUVICHKDS-UHFFFAOYSA-N 0.000 description 2
- VTYYLEPIZMXCLO-UHFFFAOYSA-L Calcium carbonate Chemical compound [Ca+2].[O-]C([O-])=O VTYYLEPIZMXCLO-UHFFFAOYSA-L 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 2
- RTAQQCXQSZGOHL-UHFFFAOYSA-N Titanium Chemical compound [Ti] RTAQQCXQSZGOHL-UHFFFAOYSA-N 0.000 description 2
- 150000008051 alkyl sulfates Chemical class 0.000 description 2
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 2
- 239000011668 ascorbic acid Substances 0.000 description 2
- 235000010323 ascorbic acid Nutrition 0.000 description 2
- 229960005070 ascorbic acid Drugs 0.000 description 2
- 239000004359 castor oil Substances 0.000 description 2
- 235000019438 castor oil Nutrition 0.000 description 2
- 239000003240 coconut oil Substances 0.000 description 2
- 235000019864 coconut oil Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 230000002950 deficient Effects 0.000 description 2
- 235000014113 dietary fatty acids Nutrition 0.000 description 2
- NOPFSRXAKWQILS-UHFFFAOYSA-N docosan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCCCCCO NOPFSRXAKWQILS-UHFFFAOYSA-N 0.000 description 2
- UKMSUNONTOPOIO-UHFFFAOYSA-N docosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCCCCC(O)=O UKMSUNONTOPOIO-UHFFFAOYSA-N 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- 238000004945 emulsification Methods 0.000 description 2
- 230000007613 environmental effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 239000000194 fatty acid Substances 0.000 description 2
- 229930195729 fatty acid Natural products 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- ZEMPKEQAKRGZGQ-XOQCFJPHSA-N glycerol triricinoleate Natural products CCCCCC[C@@H](O)CC=CCCCCCCCC(=O)OC[C@@H](COC(=O)CCCCCCCC=CC[C@@H](O)CCCCCC)OC(=O)CCCCCCCC=CC[C@H](O)CCCCCC ZEMPKEQAKRGZGQ-XOQCFJPHSA-N 0.000 description 2
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 229910001510 metal chloride Inorganic materials 0.000 description 2
- 239000010445 mica Substances 0.000 description 2
- 229910052618 mica group Inorganic materials 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 2
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 230000008719 thickening Effects 0.000 description 2
- 239000010936 titanium Substances 0.000 description 2
- 229910052719 titanium Inorganic materials 0.000 description 2
- PROQIPRRNZUXQM-UHFFFAOYSA-N (16alpha,17betaOH)-Estra-1,3,5(10)-triene-3,16,17-triol Natural products OC1=CC=C2C3CCC(C)(C(C(O)C4)O)C4C3CCC2=C1 PROQIPRRNZUXQM-UHFFFAOYSA-N 0.000 description 1
- WCGUUGGRBIKTOS-GPOJBZKASA-N (3beta)-3-hydroxyurs-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CC[C@@H](C)[C@H](C)[C@H]5C4=CC[C@@H]3[C@]21C WCGUUGGRBIKTOS-GPOJBZKASA-N 0.000 description 1
- PAFJZWHXMSQJKV-UQZRNVAESA-N (3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol;octadecanoic acid Chemical compound OC[C@@H](O)C1OC[C@H](O)[C@H]1O.OC[C@@H](O)C1OC[C@H](O)[C@H]1O.OC[C@@H](O)C1OC[C@H](O)[C@H]1O.CCCCCCCCCCCCCCCCCC(O)=O.CCCCCCCCCCCCCCCCCC(O)=O PAFJZWHXMSQJKV-UQZRNVAESA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
- BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 description 1
- ZORQXIQZAOLNGE-UHFFFAOYSA-N 1,1-difluorocyclohexane Chemical compound FC1(F)CCCCC1 ZORQXIQZAOLNGE-UHFFFAOYSA-N 0.000 description 1
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- ZONJATNKKGGVSU-UHFFFAOYSA-N 14-methylpentadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCC(O)=O ZONJATNKKGGVSU-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-UHFFFAOYSA-N 17alpha-ethynyl estradiol Natural products OC1=CC=C2C3CCC(C)(C(CC4)(O)C#C)C4C3CCC2=C1 BFPYWIDHMRZLRN-UHFFFAOYSA-N 0.000 description 1
- VOXZDWNPVJITMN-ZBRFXRBCSA-N 17β-estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H](CC4)O)[C@@H]4[C@@H]3CCC2=C1 VOXZDWNPVJITMN-ZBRFXRBCSA-N 0.000 description 1
- MPDGHEJMBKOTSU-YKLVYJNSSA-N 18beta-glycyrrhetic acid Chemical compound C([C@H]1C2=CC(=O)[C@H]34)[C@@](C)(C(O)=O)CC[C@]1(C)CC[C@@]2(C)[C@]4(C)CC[C@@H]1[C@]3(C)CC[C@H](O)C1(C)C MPDGHEJMBKOTSU-YKLVYJNSSA-N 0.000 description 1
- JNAYPSWVMNJOPQ-UHFFFAOYSA-N 2,3-bis(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C JNAYPSWVMNJOPQ-UHFFFAOYSA-N 0.000 description 1
- DVVXXHVHGGWWPE-UHFFFAOYSA-N 2-(dimethylamino)benzoic acid Chemical class CN(C)C1=CC=CC=C1C(O)=O DVVXXHVHGGWWPE-UHFFFAOYSA-N 0.000 description 1
- GECRRQVLQHRVNH-MRCUWXFGSA-N 2-octyldodecyl (z)-octadec-9-enoate Chemical compound CCCCCCCCCCC(CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC GECRRQVLQHRVNH-MRCUWXFGSA-N 0.000 description 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 1
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
- SSZWWUDQMAHNAQ-UHFFFAOYSA-N 3-chloropropane-1,2-diol Chemical group OCC(O)CCl SSZWWUDQMAHNAQ-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-GTOFXWBISA-N 3beta-hydroxyolean-12-en-28-oic acid Chemical compound C1C[C@H](O)C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C(O)=O)CCC(C)(C)C[C@H]5C4=CC[C@@H]3[C@]21C MIJYXULNPSFWEK-GTOFXWBISA-N 0.000 description 1
- HIQIXEFWDLTDED-UHFFFAOYSA-N 4-hydroxy-1-piperidin-4-ylpyrrolidin-2-one Chemical compound O=C1CC(O)CN1C1CCNCC1 HIQIXEFWDLTDED-UHFFFAOYSA-N 0.000 description 1
- OEOIWYCWCDBOPA-UHFFFAOYSA-N 6-methyl-heptanoic acid Chemical compound CC(C)CCCCC(O)=O OEOIWYCWCDBOPA-UHFFFAOYSA-N 0.000 description 1
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
- 229920002126 Acrylic acid copolymer Polymers 0.000 description 1
- 229920000178 Acrylic resin Polymers 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 235000021357 Behenic acid Nutrition 0.000 description 1
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 description 1
- 244000223760 Cinnamomum zeylanicum Species 0.000 description 1
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 1
- RGHNJXZEOKUKBD-SQOUGZDYSA-M D-gluconate Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C([O-])=O RGHNJXZEOKUKBD-SQOUGZDYSA-M 0.000 description 1
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 1
- JKLISIRFYWXLQG-UHFFFAOYSA-N Epioleonolsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4CCC3C21C JKLISIRFYWXLQG-UHFFFAOYSA-N 0.000 description 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 1
- BFPYWIDHMRZLRN-SLHNCBLASA-N Ethinyl estradiol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@](CC4)(O)C#C)[C@@H]4[C@@H]3CCC2=C1 BFPYWIDHMRZLRN-SLHNCBLASA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 229920002153 Hydroxypropyl cellulose Polymers 0.000 description 1
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical class NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- YBRJHZPWOMJYKQ-UHFFFAOYSA-N Oleanolic acid Natural products CC1(C)CC2C3=CCC4C5(C)CCC(O)C(C)(C)C5CCC4(C)C3(C)CCC2(C1)C(=O)O YBRJHZPWOMJYKQ-UHFFFAOYSA-N 0.000 description 1
- MIJYXULNPSFWEK-UHFFFAOYSA-N Oleanolinsaeure Natural products C1CC(O)C(C)(C)C2CCC3(C)C4(C)CCC5(C(O)=O)CCC(C)(C)CC5C4=CCC3C21C MIJYXULNPSFWEK-UHFFFAOYSA-N 0.000 description 1
- 239000005642 Oleic acid Substances 0.000 description 1
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
- 235000021314 Palmitic acid Nutrition 0.000 description 1
- 208000000474 Poliomyelitis Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 description 1
- 235000021355 Stearic acid Nutrition 0.000 description 1
- ULUAUXLGCMPNKK-UHFFFAOYSA-N Sulfobutanedioic acid Chemical compound OC(=O)CC(C(O)=O)S(O)(=O)=O ULUAUXLGCMPNKK-UHFFFAOYSA-N 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical class OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical class CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 1
- AWNFRSYMBMFGLK-UHFFFAOYSA-N [2,2-dimethyl-3-(16-methylheptadecanoyloxy)propyl] 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(C)(C)COC(=O)CCCCCCCCCCCCCCC(C)C AWNFRSYMBMFGLK-UHFFFAOYSA-N 0.000 description 1
- 239000006096 absorbing agent Substances 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 150000001298 alcohols Chemical class 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- 229910052783 alkali metal Inorganic materials 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 125000005210 alkyl ammonium group Chemical group 0.000 description 1
- 125000000217 alkyl group Chemical group 0.000 description 1
- SHGAZHPCJJPHSC-YCNIQYBTSA-N all-trans-retinoic acid Chemical compound OC(=O)\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C SHGAZHPCJJPHSC-YCNIQYBTSA-N 0.000 description 1
- BJEPYKJPYRNKOW-UHFFFAOYSA-N alpha-hydroxysuccinic acid Natural products OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 description 1
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 description 1
- 150000003863 ammonium salts Chemical class 0.000 description 1
- 239000002280 amphoteric surfactant Chemical group 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 125000000637 arginyl group Chemical class N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- IRERQBUNZFJFGC-UHFFFAOYSA-L azure blue Chemical compound [Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Na+].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[Al+3].[S-]S[S-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-].[O-][Si]([O-])([O-])[O-] IRERQBUNZFJFGC-UHFFFAOYSA-L 0.000 description 1
- 239000002585 base Substances 0.000 description 1
- 235000013871 bee wax Nutrition 0.000 description 1
- 239000012166 beeswax Substances 0.000 description 1
- 229940116226 behenic acid Drugs 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 229960000686 benzalkonium chloride Drugs 0.000 description 1
- 239000012965 benzophenone Substances 0.000 description 1
- 150000008366 benzophenones Chemical class 0.000 description 1
- CADWTSSKOVRVJC-UHFFFAOYSA-N benzyl(dimethyl)azanium;chloride Chemical compound [Cl-].C[NH+](C)CC1=CC=CC=C1 CADWTSSKOVRVJC-UHFFFAOYSA-N 0.000 description 1
- 229960003237 betaine Drugs 0.000 description 1
- 238000006065 biodegradation reaction Methods 0.000 description 1
- 235000019437 butane-1,3-diol Nutrition 0.000 description 1
- 229910000019 calcium carbonate Inorganic materials 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 239000010495 camellia oil Substances 0.000 description 1
- 125000004432 carbon atom Chemical group C* 0.000 description 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
- 239000004203 carnauba wax Substances 0.000 description 1
- 235000013869 carnauba wax Nutrition 0.000 description 1
- 239000003093 cationic surfactant Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 235000017803 cinnamon Nutrition 0.000 description 1
- 239000003245 coal Substances 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 229940086555 cyclomethicone Drugs 0.000 description 1
- GVJHHUAWPYXKBD-UHFFFAOYSA-N d-alpha-tocopherol Natural products OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 1
- 229940105990 diglycerin Drugs 0.000 description 1
- GPLRAVKSCUXZTP-UHFFFAOYSA-N diglycerol Chemical compound OCC(O)COCC(O)CO GPLRAVKSCUXZTP-UHFFFAOYSA-N 0.000 description 1
- 229940008099 dimethicone Drugs 0.000 description 1
- 239000004205 dimethyl polysiloxane Substances 0.000 description 1
- 235000013870 dimethyl polysiloxane Nutrition 0.000 description 1
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 229960000735 docosanol Drugs 0.000 description 1
- QZUNHWGQSGFRAR-UHFFFAOYSA-N dodecyl octadecanoate;sodium Chemical compound [Na].CCCCCCCCCCCCCCCCCC(=O)OCCCCCCCCCCCC QZUNHWGQSGFRAR-UHFFFAOYSA-N 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 229960003720 enoxolone Drugs 0.000 description 1
- 230000032050 esterification Effects 0.000 description 1
- 238000005886 esterification reaction Methods 0.000 description 1
- 229960005309 estradiol Drugs 0.000 description 1
- 229930182833 estradiol Natural products 0.000 description 1
- 229960001348 estriol Drugs 0.000 description 1
- PROQIPRRNZUXQM-ZXXIGWHRSA-N estriol Chemical compound OC1=CC=C2[C@H]3CC[C@](C)([C@H]([C@H](O)C4)O)[C@@H]4[C@@H]3CCC2=C1 PROQIPRRNZUXQM-ZXXIGWHRSA-N 0.000 description 1
- RTZKZFJDLAIYFH-UHFFFAOYSA-N ether Substances CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 1
- 229960002568 ethinylestradiol Drugs 0.000 description 1
- 150000004665 fatty acids Chemical class 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 229940050410 gluconate Drugs 0.000 description 1
- 229940074774 glycyrrhizinate Drugs 0.000 description 1
- LPLVUJXQOOQHMX-QWBHMCJMSA-N glycyrrhizinic acid Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@@H]1C([C@H]2[C@]([C@@H]3[C@@]([C@@]4(CC[C@@]5(C)CC[C@@](C)(C[C@H]5C4=CC3=O)C(O)=O)C)(C)CC2)(C)CC1)(C)C)C(O)=O)[C@@H]1O[C@H](C(O)=O)[C@@H](O)[C@H](O)[C@H]1O LPLVUJXQOOQHMX-QWBHMCJMSA-N 0.000 description 1
- BXWNKGSJHAJOGX-UHFFFAOYSA-N hexadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCO BXWNKGSJHAJOGX-UHFFFAOYSA-N 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 229940071676 hydroxypropylcellulose Drugs 0.000 description 1
- 150000002500 ions Chemical class 0.000 description 1
- 159000000014 iron salts Chemical class 0.000 description 1
- 230000007794 irritation Effects 0.000 description 1
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
- 229940074928 isopropyl myristate Drugs 0.000 description 1
- 229940119170 jojoba wax Drugs 0.000 description 1
- 229940057995 liquid paraffin Drugs 0.000 description 1
- ZLNQQNXFFQJAID-UHFFFAOYSA-L magnesium carbonate Chemical compound [Mg+2].[O-]C([O-])=O ZLNQQNXFFQJAID-UHFFFAOYSA-L 0.000 description 1
- 239000001095 magnesium carbonate Substances 0.000 description 1
- 229910000021 magnesium carbonate Inorganic materials 0.000 description 1
- 239000001630 malic acid Substances 0.000 description 1
- 235000011090 malic acid Nutrition 0.000 description 1
- 150000002696 manganese Chemical class 0.000 description 1
- 239000004200 microcrystalline wax Substances 0.000 description 1
- 235000019808 microcrystalline wax Nutrition 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 description 1
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 description 1
- 229940100540 neopentyl glycol diisostearate Drugs 0.000 description 1
- 230000007935 neutral effect Effects 0.000 description 1
- 150000002815 nickel Chemical class 0.000 description 1
- QIQXTHQIDYTFRH-UHFFFAOYSA-N octadecanoic acid Chemical compound CCCCCCCCCCCCCCCCCC(O)=O QIQXTHQIDYTFRH-UHFFFAOYSA-N 0.000 description 1
- OQCDKBAXFALNLD-UHFFFAOYSA-N octadecanoic acid Natural products CCCCCCCC(C)CCCCCCCCC(O)=O OQCDKBAXFALNLD-UHFFFAOYSA-N 0.000 description 1
- 229940100243 oleanolic acid Drugs 0.000 description 1
- 229940049964 oleate Drugs 0.000 description 1
- 229960002969 oleic acid Drugs 0.000 description 1
- XMLQWXUVTXCDDL-UHFFFAOYSA-N oleyl alcohol Natural products CCCCCCC=CCCCCCCCCCCO XMLQWXUVTXCDDL-UHFFFAOYSA-N 0.000 description 1
- 229940055577 oleyl alcohol Drugs 0.000 description 1
- 235000008390 olive oil Nutrition 0.000 description 1
- 239000004006 olive oil Substances 0.000 description 1
- 239000012188 paraffin wax Substances 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 description 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 description 1
- 239000001818 polyoxyethylene sorbitan monostearate Substances 0.000 description 1
- 235000010989 polyoxyethylene sorbitan monostearate Nutrition 0.000 description 1
- 229920000053 polysorbate 80 Polymers 0.000 description 1
- 229910000027 potassium carbonate Inorganic materials 0.000 description 1
- 159000000001 potassium salts Chemical class 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000002335 preservative effect Effects 0.000 description 1
- HZLWUYJLOIAQFC-UHFFFAOYSA-N prosapogenin PS-A Natural products C12CC(C)(C)CCC2(C(O)=O)CCC(C2(CCC3C4(C)C)C)(C)C1=CCC2C3(C)CCC4OC1OCC(O)C(O)C1O HZLWUYJLOIAQFC-UHFFFAOYSA-N 0.000 description 1
- 239000011677 pyridoxine Substances 0.000 description 1
- 235000008160 pyridoxine Nutrition 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 229930002330 retinoic acid Natural products 0.000 description 1
- 229960003471 retinol Drugs 0.000 description 1
- 235000020944 retinol Nutrition 0.000 description 1
- 239000011607 retinol Substances 0.000 description 1
- 239000002151 riboflavin Substances 0.000 description 1
- 229960002477 riboflavin Drugs 0.000 description 1
- 235000019192 riboflavin Nutrition 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000000344 soap Substances 0.000 description 1
- 159000000000 sodium salts Chemical class 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000001593 sorbitan monooleate Substances 0.000 description 1
- 235000011069 sorbitan monooleate Nutrition 0.000 description 1
- 229940035049 sorbitan monooleate Drugs 0.000 description 1
- 239000001587 sorbitan monostearate Substances 0.000 description 1
- 235000011076 sorbitan monostearate Nutrition 0.000 description 1
- 229940035048 sorbitan monostearate Drugs 0.000 description 1
- 229940032094 squalane Drugs 0.000 description 1
- 230000000087 stabilizing effect Effects 0.000 description 1
- 239000008117 stearic acid Substances 0.000 description 1
- 150000003431 steroids Chemical class 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 230000002123 temporal effect Effects 0.000 description 1
- DOMXUEMWDBAQBQ-WEVVVXLNSA-N terbinafine Chemical compound C1=CC=C2C(CN(C\C=C\C#CC(C)(C)C)C)=CC=CC2=C1 DOMXUEMWDBAQBQ-WEVVVXLNSA-N 0.000 description 1
- 229960002722 terbinafine Drugs 0.000 description 1
- 150000003505 terpenes Chemical class 0.000 description 1
- 235000007586 terpenes Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- TUNFSRHWOTWDNC-HKGQFRNVSA-N tetradecanoic acid Chemical compound CCCCCCCCCCCCC[14C](O)=O TUNFSRHWOTWDNC-HKGQFRNVSA-N 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- 239000011732 tocopherol Substances 0.000 description 1
- 229960001295 tocopherol Drugs 0.000 description 1
- 235000010384 tocopherol Nutrition 0.000 description 1
- 229930003799 tocopherol Natural products 0.000 description 1
- 229910052723 transition metal Inorganic materials 0.000 description 1
- 229960001727 tretinoin Drugs 0.000 description 1
- 150000003626 triacylglycerols Chemical class 0.000 description 1
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 description 1
- PLSAJKYPRJGMHO-UHFFFAOYSA-N ursolic acid Natural products CC1CCC2(CCC3(C)C(C=CC4C5(C)CCC(O)C(C)(C)C5CCC34C)C2C1C)C(=O)O PLSAJKYPRJGMHO-UHFFFAOYSA-N 0.000 description 1
- 229940096998 ursolic acid Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 229940011671 vitamin b6 Drugs 0.000 description 1
- 239000001993 wax Substances 0.000 description 1
- 239000010497 wheat germ oil Substances 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 150000003751 zinc Chemical class 0.000 description 1
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 1
Landscapes
- Cosmetics (AREA)
Abstract
Description
【０００１】
【発明の属する技術分野】
本発明は、皮膚外用剤に好適な乳化組成物に関し、更に詳細には、天然物由来の増粘乳化剤を使用する、皮膚外用剤に好適な乳化組成物に関する。
【０００２】
【従来の技術】
乳化組成物は、水性成分と油性成分が、連続相と乳化粒子に分かれて含有される為、油溶性成分の担体としても、水溶性成分の担体としても好適である為、複数の有効成分を含有する、化粧料や皮膚外用医薬などの分野で有用な製剤として使用されている。この様な乳化組成物は、成分としては、主として親水性成分、油性成分及び界面活性剤から構成されている。中でも界面活性剤は、互いには混じらない親水性成分と油性成分とを均一な分散状態に分散させるには必須の成分である。界面活性剤としては、石けんやアルキル硫酸エステル塩などのアニオン界面活性剤やポリオキシエチレン付加型、或いは多価アルコールの部分エステル型の非イオン界面活性剤が、皮膚外用剤の分野では広く使用されている。この内、アニオン界面活性剤には、一時刺激性の面で改善すべきがあり、非イオン界面活性剤では、経時的なホルマリン発生の面で改善すべき点があった。更に、生分解されにくい特性から、環境科学的には、「持続可能な発展」の京都議定書の主旨とは相容れない面があり、改善される余地を残している。この為、界面活性剤を使用しない乳化系の開発が、皮膚外用剤の分野では長年の課題となっていた。
【０００３】
この様な背景から、界面活性剤を使用しない乳化製剤も幾つか考案されている。例えば特許文献１、２に示されているような、長鎖のアルキル基を側鎖に有するアクリル酸コポリマーを利用したものなどがその代表的な例として例示できる。しかしながら、この様なポリマーに於いては、ポリマーを作成するときに生じる残留モノマーが、安全性の観点から懸念される。加えて、かかるポリマーも界面活性剤と同様、環境科学的には生分解されにくいものであり、「持続可能な発展」の京都議定書の主旨からすれば、改善される余地を残していた。即ち、合成ポリマーも、界面活性剤も使用しない乳化組成物の開発が望まれている。
【０００４】
一方、アルギン酸はそのカルシウム塩などが被膜形成剤として、化粧料に使用されているし、アルギン酸の多価アルコールエステルは、皮膚保護成分、或いは、増粘成分として化粧料などに使用されることが知られている。（特許文献３〜１０）しかしながら、１）アルギン酸の多価アルコールエステルと２）アルギン酸及び／又はその塩を含有することを構成とする乳化物は知られていないし、かかる構成を取ることにより、合成ポリマーも、界面活性剤も使用しない乳化組成物が得られることも全く知られていない。
【特許文献１】特開２００２−２６５３１９
【特許文献２】特開２００２−２３４８３０
【特許文献３】特開２００２−１９４１６８
【特許文献４】特開２００２−９７１２５
【特許文献５】特開２００２−４７１２３
【特許文献６】特開平１０−６７６４３
【特許文献７】特開平１０−６７６４２
【特許文献８】特開平０９−２５５５６２
【特許文献９】特開平０９−１２４４４１
【特許文献１０】特開平０９−７７６２８
【０００５】
【発明が解決しようとする課題】
本発明は、この様な状況下為されたものであり、皮膚外用剤として好適な、合成ポリマーも、界面活性剤も使用しない乳化組成物を提供することを課題とする。
【０００６】
【課題の解決手段】
本発明者らは、かかる状況に鑑みて、皮膚外用剤として好適な、合成ポリマーも、界面活性剤も使用しない乳化組成物を求めて、鋭意研究努力を重ねた結果、
１）アルギン酸の多価アルコールエステルと２）アルギン酸及び／又はその塩を含有する乳化組成物がその様な特性を備えていることを見出し、発明を完成させるに至った。即ち、本発明は以下に示す技術に関するものである。
（１）１）アルギン酸の多価アルコールエステルと２）アルギン酸及び／又はその塩を含有することを特徴とする、乳化組成物。
（２）アルギン酸の多価アルコールエステルが、アルギン酸プロピレングリコールエステルであることを特徴とする、（１）に記載の乳化組成物。
（３）アルギン酸及び／又はその塩として、アルギン酸の多価金属塩を含むことを特徴とする、（１）又は（２）に記載の乳化組成物。
（４）アルギン酸の多価金属塩が、アルギン酸カルシウム、アルギン酸マグネシウム、アルギン酸アルミニウム及びアルギン酸亜鉛から選択される１種乃至は２種以上であることを特徴とする、（１）〜（３）何れか１項に記載の乳化組成物。
（５）多価金属根の含有量が、塩化物に換算して０．００１〜０．５重量％であることを特徴とする、（１）〜（４）何れか１項に記載の乳化組成物。
（６）皮膚外用剤であることを特徴とする、（１）〜（５）何れか１項に記載の乳化組成物。
【０００７】
【発明の実施の形態】
（１）本発明の乳化組成物の必須成分であるアルギン酸の多価アルコールエステル
本発明の乳化組成物は、アルギン酸の多価アルコールのエステルを必須成分として含有する。ここで、アルギン酸の多価アルコールのエステルを構成する多価アルコールとしては、皮膚外用剤などで使用されているものであれば特段の限定なく使用することが出来、炭素数２〜４のものが好ましく、エーテル結合を持たないものが好ましい。具体的には、プロピレングリコール、グリセリン、１，３−ブタンジオール、エチレングリコール等が好ましく例示でき、中でも親水性と親油性のバランスから、プロピレングリコールが特に好ましく例示できる。これらのアルギン酸の多価アルコールのエステルは何れも既知化合物であり、その製造方法は既に知られている。かかるアルギン酸の多価アルコールのエステルの製造法としては、アルギン酸ナトリウム等のアルギン酸の塩と、対応する多価アルコールのモノハロゲン化物を、アルカリ存在下反応させることが例示できる。例えば、アルギン酸プロピレングリコールエステルであれば、アルギン酸ナトリウムと１−クロル−２−プロパノールを含水アルコール中で炭酸カリウムなどを存在させて反応させればよいし、アルギン酸グリセリルエステルであれば、前記の反応の１−クロル−ープロパノールを１−クロル−２，３−プロパンジオールに代えて同様に処理すれば製造することが出来る。又、この様なエステル類に既に市販されているものも存在し、その様な市販品を購入して利用することも出来る。好適な市販品としては、例えば、アルギン酸プロピレングリコールエステルであれば、株式会社キミカから販売されている、「キミロイドＬＬＶ」、「キミロイドＬＶ」、「キミロイドＭＶ」、「キミロイＨＶ」、「キミロイドＢＦ」、「キミロイドＮＬＳＫ」等が挙げられる。これらは、粘度とエステル化度がことなる。本発明の乳化組成物として使用する上で、特に好ましいものは、「キミロイドＮＬＳＫ」である。本発明の乳化組成物に於いて、かかるアルギン酸の多価アルコールのエステルは、油性成分を安定に乳化分散させる作用を有する。これらのアルギン酸の多価アルコールのエステルは唯一種を含有させることも出来るし、二種以上組み合わせて含有させることも出来る。本発明の乳化組成物に於ける、かかるアルギン酸の多価アルコールエステルの好ましい含有量は、乳化組成物全量に対して、総量で、１〜５重量％であり、更に好ましくは１．２〜２重量％である。これは少なすぎると乳化安定性が損なわれる場合があり、多すぎると、固くなり過ぎて、使用性を損なう場合があるからである。
【０００８】
（２）本発明の乳化組成物の必須成分であるアルギン酸及び／又はその塩
本発明の乳化組成物は、アルギン酸及び／又はその塩を必須成分として含有する。かかるアルギン酸及び／又はその塩としては、アルギン酸塩を含む形態が好ましい。前記アルギン酸塩としては、例えば、ナトリウム塩、カリウム塩等のアルカリ金属塩、カルシウム、マグネシウム等のアルカリ土類金属塩、亜鉛塩、アルミニウム塩等の中性金属塩、マンガン塩、鉄塩、ニッケル塩等の遷移金属塩、アンモニウム塩、トリエタノールアミン塩、トリエチルアミン塩等の有機アミン塩類、リジン塩、アルギニン塩等の塩基性アミノ酸塩等が好ましく例示できる。中でも、カルシウム、マグネシウム、亜鉛、アルミニウム等の多価金属根を対イオンとする形態を含むものがより好ましい。本発明の乳化組成物に於いて、アルギン酸及び／又はその塩は前記アルギン酸の多価アルコールのエステルによって乳化された系を安定化する作用を有する。本発明の乳化組成物に於いて、アルギン酸及び／又はその塩の好ましい含有量は、アルギン酸ナトリウム換算で、０．０５〜５重量％が好ましく、０．１〜２重量％が更に好ましい。更に加えて、多価金属根を、塩化物に換算して、０．０００５〜０．２５重量％、より好ましくは０．００５〜０．２重量％含有することがより好ましい。
【０００９】
（３）本発明の乳化組成物
本発明の乳化組成物は、上記必須成分を含有することを特徴とする。本発明の乳化組成物は、通常乳化形態が製剤として用いられる組成物全体に適用できる。例えば、食品組成物、医薬組成物、化粧料や皮膚外用医薬などの皮膚外用剤が好適に例示でき、皮膚外用剤が特に好適である。本発明の乳化組成物に於いては、前記必須成分以外に、通常乳化組成物で使用される任意成分を、本発明の効果を損なわない範囲に於いて、含有することが出来る。かかる任意成分としては、例えば、スクワラン、流動パラフィン、軽質流動イソパラフィン、重質流動イソパラフィン、マイクロクリスタリンワックス、固形パラフィンなどの炭化水素類、ジメチコン、フェメチコン、シクロメチコン、アモジメチコン、ポリエーテル変性シリコーンなどのシリコーン類、ホホバ油、カルナウバワックス、モクロウ、ミツロウ、ゲイロウ、オレイン酸オクチルドデシル、イソプロピルミリステート、ネオペンチルグリコールジイソステアレート、リンゴ酸ジイソステアレートなどのエステル類、ステアリン酸、ラウリン酸、ミリスチン酸、パルミチン酸、イソステアリン酸、イソパルミチン酸、ベヘン酸、オレイン酸などの脂肪酸類、ベヘニルアルコール、セタノール、オレイルアルコール、オクタデシルアルコールなどの高級アルコール類、ヒマシ油、椰子油、水添椰子油、椿油、小麦胚芽油、イソステアリン酸トリグリセライド、イソオクタン酸トリグリセライド、オリーブオイル等のトリグリセライド類、１，３−ブタンジオール、グリセリン、ジグリセリン、ジプロピレングリコール、ポリエチレングリコール、１，２−ペンタンジオール、１，２−ヘキシレングリコール、イソプレングリコールなどの多価アルコール、ソルビタンセスキオレート、ソルビタンモノオレート、ソルビタントリオレート、ソルビタンセスキステアレート、ソルビタンモノステアレート、ポリオキシエチレンソルビタンモノオレート、ポリオキシエチレンソルビタンモノステアレート、ポリオキシエチレンステアレート、ポリオキシエチレンオレート、ポリオキシエチレングリセリル脂肪酸エステル、ポリエキシエチレンアルキルエーテル、ポリオキシエチレン硬化ヒマシ油等の非イオン界面活性剤、ソジウムラウリルステアレート、ポリオキシエチレンアルキル硫酸塩、スルホコハク酸エステル塩などのアニオン界面活性剤、４級アルキルアンモニウム塩等のカチオン界面活性剤類、アルキルベタイン等の両性界面活性剤類、結晶セルロースや架橋型メチルポリシロキサン、ポリエチレン粉末、アクリル樹脂粉体等の有機粉体類、タルク、マイカ、セリサイト、炭酸マグネシウム、炭酸カルシウム、二酸化チタン、酸化鉄、紺青、群青、チタンマイカ、チタンセリサイト、シリカ等の表面処理されていても良い粉体類、アクリル酸・メタクリル酸アルキルコポリマー及び／又はその塩、カルボキシビニルポリマー及び／又はその塩、キサンタンガムやヒドロキシプロピルセルロースなどの増粘剤、レチノール、レチノイン酸、トコフェロール、リボフラビン、ピリドキシン、アスコルビン酸、アスコルビン酸リン酸エステル塩などのビタミンやグリチルリチン酸塩、グリチルレチン、ウルソール酸、オレアノール酸などのテルペン類、エストラジオール、エチニルエストラジオール、エストリオールなどのステロイド類などの有効成分、フェノキシエタノール、パラベン類、ヒビテングルコネート、塩化ベンザルコニウム等の防腐剤、ジメチルアミノ安息香酸エステル類、桂皮酸エステル類、ベンゾフェノン類などの紫外線吸収剤などが好ましく例示できる。これらの内、界面活性剤、アクリル酸・メタクリル酸アルキルコポリマー及び／又はその塩、カルボキシビニルポリマー及び／又はその塩等の合成のポリマーは、本発明の主旨からすれば、実質的に含有しないことが好ましい。又、本発明の乳化組成物が生分解を受けやすい長所を有することから、これのデメリット面である防腐効果の弱さが存在し、これを補完する意味で、１，３−ブタンジオール、１，２−ペンタンジオール、イソプレングリコール、１，２−ヘキシレングリコール、より好ましくは１，２−ペンタンジオール、１，２−ヘキシレングリコール等の抗菌性多価アルコールを含有することが好ましい。かかる多価アルコールの好ましい含有量は、総量で乳化組成物全量に対して、１〜１０重量％である。本発明の乳化組成物は、これら必須成分及び任意成分を常法に従って処理することにより製造することが出来る。
【００１０】
【実施例】
以下に、実施例を挙げて、本発明について更に詳細に説明を加えるが、本発明が実施例にのみ限定されないことは言うまでもない。
【００１１】
＜実施例１＞
以下に示す処方に従って、本発明の乳化組成物１（化粧料）を作成した。即ち、イ、ロ、ハ、ニをそれぞれ８０℃に温調し、攪拌下イにロを加え、均一に分散、溶解させ、更に、攪拌下ハを加えて、塩基交換を行い、これに強攪拌下徐々にニを加えて乳化し、攪拌冷却し乳化組成物１を乳液として得た。同時にアルギン酸ナトリウムをアルギン酸プロピレングリコールエステルに置換した比較例１、アルギン酸プロピレングリコールエステルをアルギン酸に置換した比較例２、アルギン酸ナトリウムを水に置換した対照例１、アルギン酸プロピレングリコールエステルを水に置換した対照例２、アルギン酸ナトリウムとアルギン酸プロピレングリコールエステルをアルギン酸に置換した対照例３も作成した。これらについて、顕微鏡で乳化性を、５℃、２０℃、４０℃での２週間の保存試験で安定性を評価した。評価基準は、○：良好、△：部分的に不良、×：不良を用いた。結果を表１に示す。これより、本発明の乳化組成物が、乳化性もその安定性も極めて良好であることがわかる。又、乳化組成物１は専門パネラーによる評価に於いて、化粧料としての要件を備えているとの評価を得た。
イ
アルギン酸ナトリウム ０．１重量部
アルギン酸プロピレングリコールエステル １．５重量部
（キミロイドＮＬＳＫ）
１，２−ヘキシレングリコール ５ 重量部
ロ
水 ７０ 重量部
ハ
塩化カルシウム ０．００１重量部
水 １３．３９９重量部
ニ
スクワラン ５ 重量部
グリセリルトリイソオクタネート ５ 重量部
【００１２】
【表１】
【００１３】
＜実施例２＞
乳化組成物１のアルギン酸プロピレングリコールエステルの量を変化させて、実施例１と同様に乳化組成物２〜４（何れも化粧料）を作成し、評価して、その影響を見た。結果を表２に示す。これより、アルギン酸の多価アルコールエステルの好ましい含有量は、乳化組成物全量に対して、総量で、１〜５重量％であり、更に好ましくは１．２〜２重量％であることがわかる。又、乳化組成物２〜４は専門パネラーによる評価に於いて、化粧料としての要件を備えているとの評価を得た。
イ
アルギン酸ナトリウム ０．１重量部
アルギン酸プロピレングリコールエステル ＊重量部
（キミロイドＮＬＳＫ）
１，２−ヘキシレングリコール ５ 重量部
ロ
水 ７１．５−＊重量部
ハ
塩化カルシウム ０．００１重量部
水 １３．３９９重量部
ニ
スクワラン ５ 重量部
グリセリルトリイソオクタネート ５ 重量部
＊は表２に記す。
【００１４】
【表２】
＜実施例３＞
乳化組成物１の塩化カルシウムの量を変化させて、実施例１と同様に乳化組成物５〜７（何れも化粧料）を作成し、評価して、その影響を見た。結果を表３に示す。これより、塩化カルシウム等の多価金属根の好ましい含有量は、乳化組成物全量に対して、総量で、１塩化物に換算して、０．０００５〜０．２５重量％、より好ましくは０．００５〜０．２重量％であることがわかる。又、乳化組成物５〜７は専門パネラーによる評価に於いて、化粧料としての要件を備えているとの評価を得た。
イ
アルギン酸ナトリウム ０．１重量部
アルギン酸プロピレングリコールエステル １．５重量部
（キミロイドＮＬＳＫ）
１，２−ヘキシレングリコール ５ 重量部
ロ
水 ７０ 重量部
ハ
塩化カルシウム ＊＊重量部
水 １３．４−＊＊重量部
ニ
スクワラン ５ 重量部
グリセリルトリイソオクタネート ５ 重量部
＊＊は表３に記す。
【００１６】
【表３】
＜実施例４＞
乳化組成物１のアルギン酸プロピレングリコールエステルのグレードを変えて、実施例１と同様に乳化組成物８〜７（何れも化粧料）を作成し、評価して、その影響を見た。結果を表４に示す。これより、何れのグレードのものでも使用可能であることがわかる。
イ
アルギン酸ナトリウム ０．１重量部
アルギン酸プロピレングリコールエステル １．５重量部
（表４に記載の商品）
１，２−ヘキシレングリコール ５ 重量部
ロ
水 ７０ 重量部
ハ
塩化カルシウム ０．００１重量部
水 １３．３９９重量部
ニ
スクワラン ５ 重量部
グリセリルトリイソオクタネート ５ 重量部
【００１８】
【表４】
＜実施例５＞
乳化組成物１の塩化カルシウムを他の多価金属塩化物に置換して、実施例４と同様の検討を行った。何れの多価金属塩化物も使用可能であることがわかる。又、カルシウムが特に好ましいこともわかる。
イ
アルギン酸ナトリウム ０．１重量部
アルギン酸プロピレングリコールエステル １．５重量部
（「キミロイドＮＬＳＫ」）
１，２−ヘキシレングリコール ５ 重量部
ロ
水 ７０ 重量部
ハ
表５に記載の成分 ０．００１重量部
水 １３．３９９重量部
ニ
スクワラン ５ 重量部
グリセリルトリイソオクタネート ５ 重量部
【００２０】
【表５】
＜実施例６＞
実施例１と同様に操作して、乳化組成物１８（皮膚外用医薬）を作成した。
イ
アルギン酸ナトリウム ０．１重量部
アルギン酸プロピレングリコールエステル １．５重量部
（キミロイドＮＬＳＫ）
１，２−ヘキシレングリコール ５ 重量部
ロ
水 ７０ 重量部
ハ
塩化カルシウム ０．００１重量部
水 １１．３９９重量部
ニ
スクワラン ５ 重量部
グリセリルトリイソオクタネート ５ 重量部
テルビナフィン ２ 重量部
【００２２】
【発明の効果】
本発明によれば、皮膚外用剤として好適な、合成ポリマーも、界面活性剤も使用しない乳化組成物を提供することができる。[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to an emulsified composition suitable for an external preparation for skin, and more particularly to an emulsified composition suitable for an external preparation for skin using a thickening emulsifier derived from a natural product.
[0002]
[Prior art]
The emulsion composition contains an aqueous component and an oil component, which are separated into a continuous phase and emulsified particles, so that it is suitable as a carrier for the oil-soluble component and also as a carrier for the water-soluble component. It is used as a useful formulation in fields such as cosmetics and external medicine for skin. Such an emulsified composition is mainly composed of a hydrophilic component, an oily component and a surfactant. Among them, a surfactant is an essential component for dispersing a hydrophilic component and an oil component that are not mixed with each other in a uniform dispersion state. As surfactants, anionic surfactants such as soaps and alkyl sulfates, and non-ionic surfactants of polyoxyethylene addition type or partial ester type of polyhydric alcohol are widely used in the field of skin external preparations. ing. Among them, anionic surfactants need to be improved in terms of temporary irritation, and nonionic surfactants have an improvement in terms of temporal generation of formalin. Furthermore, due to its characteristics of being difficult to biodegrade, environmental science is incompatible with the Kyoto Protocol on "Sustainable Development" and leaves room for improvement. For this reason, development of an emulsification system without using a surfactant has been a long-standing problem in the field of skin external preparations.
[0003]
Against this background, some emulsified formulations that do not use surfactants have been devised. For example, those using an acrylic acid copolymer having a long-chain alkyl group in a side chain as shown in Patent Documents 1 and 2 can be exemplified as typical examples. However, in such a polymer, residual monomers generated when the polymer is prepared are concerned from the viewpoint of safety. In addition, such polymers, like surfactants, are not easily biodegradable in terms of environmental science, leaving room for improvement in the spirit of the Kyoto Protocol for “Sustainable Development”. That is, development of an emulsion composition using neither a synthetic polymer nor a surfactant is desired.
[0004]
On the other hand, alginic acid is used in cosmetics as its calcium salt or the like as a film-forming agent, and polyhydric alcohol ester of alginic acid is used in cosmetics as a skin-protecting component or a thickening component. Are known. (Patent Documents 3 to 10) However, an emulsion comprising 1) a polyhydric alcohol ester of alginic acid and 2) alginic acid and / or a salt thereof is not known, and is synthesized by adopting such a constitution. It is not known at all that an emulsified composition using neither a polymer nor a surfactant can be obtained.
[Patent Document 1] JP-A-2002-265319
[Patent Document 2] JP-A-2002-234830
[Patent Document 3] JP-A-2002-194168
[Patent Document 4] JP-A-2002-97125
[Patent Document 5] JP-A-2002-47123
[Patent Document 6] JP-A-10-67643
[Patent Document 7] JP-A-10-67642
[Patent Document 8] JP-A-09-255562
[Patent Document 9] JP-A-09-124441
[Patent Document 10] JP-A-09-77628
[0005]
[Problems to be solved by the invention]
The present invention has been made in such a situation, and an object of the present invention is to provide an emulsified composition which is suitable as an external preparation for the skin and uses neither a synthetic polymer nor a surfactant.
[0006]
[Means for solving the problem]
In view of such circumstances, the present inventors have searched for an emulsified composition that does not use a synthetic polymer or a surfactant that is suitable as an external preparation for the skin, and as a result of intensive research efforts,
The inventors have found that an emulsified composition containing 1) a polyhydric alcohol ester of alginic acid and 2) alginic acid and / or a salt thereof has such properties, and have completed the invention. That is, the present invention relates to the following technology.
An emulsified composition comprising (1) 1) a polyhydric alcohol ester of alginic acid and 2) alginic acid and / or a salt thereof.
(2) The emulsion composition according to (1), wherein the polyhydric alcohol ester of alginic acid is alginic acid propylene glycol ester.
(3) The emulsified composition according to (1) or (2), wherein the emulsion composition comprises, as alginic acid and / or a salt thereof, a polyvalent metal salt of alginic acid.
(4) The polyvalent metal salt of alginic acid is one or more selected from calcium alginate, magnesium alginate, aluminum alginate and zinc alginate, any one of (1) to (3). Item 2. The emulsion composition according to item 1.
(5) The emulsification according to any one of (1) to (4), wherein the content of the polyvalent metal root is 0.001 to 0.5% by weight in terms of chloride. Composition.
(6) The emulsion composition according to any one of (1) to (5), which is an external preparation for skin.
[0007]
BEST MODE FOR CARRYING OUT THE INVENTION
(1) Polyhydric alcohol ester of alginic acid which is an essential component of the emulsion composition of the present invention The emulsion composition of the present invention contains an ester of a polyhydric alcohol of alginic acid as an essential component. Here, the polyhydric alcohol constituting the ester of the polyhydric alcohol of alginic acid can be used without any particular limitation as long as it is used in an external preparation for skin and the like, and those having 2 to 4 carbon atoms can be used. Those having no ether bond are preferred. Specifically, propylene glycol, glycerin, 1,3-butanediol, ethylene glycol and the like can be preferably exemplified. Among them, propylene glycol can be particularly preferably exemplified from the balance between hydrophilicity and lipophilicity. All of these polyhydric alcohol esters of alginic acid are known compounds, and their production methods are already known. Examples of the method for producing the ester of polyhydric alcohol of alginic acid include reacting a salt of alginic acid such as sodium alginate with a monohalide of the corresponding polyhydric alcohol in the presence of an alkali. For example, in the case of propylene glycol alginate, sodium alginate and 1-chloro-2-propanol may be reacted in the presence of potassium carbonate or the like in a hydroalcoholic alcohol, or in the case of glyceryl alginate, the above reaction may be performed. It can be produced by treating in the same manner as above except that 1-chloro-2-propanol is replaced with 1-chloro-2,3-propanediol. Some of such esters are already commercially available, and such commercially available products can be purchased and used. Suitable commercial products include, for example, propylene glycol alginate sold by Kimika Co., Ltd., "Kimiloid LLV", "Kimiloid LV", "Kimiloid MV", "Kimiloid HV", "Kimiloid BF". , “Kimiloid NLSK” and the like. These have different viscosities and degrees of esterification. Particularly preferred for use as the emulsified composition of the present invention is "Kimiloid NLSK". In the emulsified composition of the present invention, the ester of polyhydric alcohol of alginic acid has an effect of stably emulsifying and dispersing an oil component. These esters of polyhydric alcohols of alginic acid may contain only one kind or two or more kinds in combination. The content of the polyhydric alcohol ester of alginic acid in the emulsion composition of the present invention is preferably 1 to 5% by weight, more preferably 1.2 to 2% by weight based on the total weight of the emulsion composition. % By weight. If the amount is too small, the emulsion stability may be impaired. If the amount is too large, the composition may be too hard and the usability may be impaired.
[0008]
(2) Alginic acid and / or its salt which is an essential component of the emulsion composition of the present invention The emulsion composition of the present invention contains alginic acid and / or its salt as an essential component. As the alginic acid and / or a salt thereof, a form containing an alginate is preferable. Examples of the alginate include alkali metal salts such as sodium salts and potassium salts, alkaline earth metal salts such as calcium and magnesium, zinc salts, neutral metal salts such as aluminum salts, manganese salts, iron salts and nickel salts. Preferred examples thereof include organic amine salts such as transition metal salts, ammonium salts, triethanolamine salts and triethylamine salts, and basic amino acid salts such as lysine salts and arginine salts. Among them, those containing a form in which a polyvalent metal root such as calcium, magnesium, zinc, and aluminum is used as a counter ion are more preferable. In the emulsified composition of the present invention, alginic acid and / or a salt thereof has an action of stabilizing a system emulsified by the ester of polyhydric alcohol of alginic acid. In the emulsified composition of the present invention, the content of alginic acid and / or a salt thereof is preferably 0.05 to 5% by weight, more preferably 0.1 to 2% by weight in terms of sodium alginate. In addition, it is more preferable that the polyvalent metal root be contained in an amount of 0.0005 to 0.25% by weight, more preferably 0.005 to 0.2% by weight in terms of chloride.
[0009]
(3) Emulsion composition of the present invention The emulsion composition of the present invention is characterized by containing the above essential components. The emulsified composition of the present invention can be applied to the entire composition in which an emulsified form is usually used as a preparation. For example, a skin external preparation such as a food composition, a pharmaceutical composition, a cosmetic or a skin external medicine can be preferably exemplified, and a skin external preparation is particularly preferable. In the emulsion composition of the present invention, in addition to the above essential components, optional components usually used in the emulsion composition can be contained as long as the effects of the present invention are not impaired. Such optional components include, for example, squalane, liquid paraffin, light liquid isoparaffin, heavy liquid isoparaffin, microcrystalline wax, hydrocarbons such as solid paraffin, dimethicone, femethicone, cyclomethicone, amodimethicone, and polyether-modified silicone. Silicones, jojoba oil, carnauba wax, mokuro, beeswax, gay wax, octyldodecyl oleate, isopropyl myristate, neopentyl glycol diisostearate, esters such as malic acid diisostearate, stearic acid, lauric acid, Fatty acids such as myristic acid, palmitic acid, isostearic acid, isopalmitic acid, behenic acid, oleic acid, behenyl alcohol, cetanol, oleyl alcohol, octadecyl alcohol Higher alcohols such as coal, castor oil, coconut oil, hydrogenated coconut oil, camellia oil, wheat germ oil, triglycerides such as isostearic acid triglyceride, isooctanoic acid triglyceride and olive oil, 1,3-butanediol, glycerin, diglycerin , Dipropylene glycol, polyethylene glycol, 1,2-pentanediol, 1,2-hexylene glycol, polyhydric alcohols such as isoprene glycol, sorbitan sesquiolate, sorbitan monooleate, sorbitan triolate, sorbitan sesquistearate, sorbitan mono Stearate, polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene stearate, polyoxyethylene oleate, polio Non-ionic surfactants such as ciethylene glyceryl fatty acid ester, polyexylene ethylene alkyl ether, and polyoxyethylene hydrogenated castor oil; anionic surfactants such as sodium lauryl stearate, polyoxyethylene alkyl sulfate, and sulfosuccinate; Cationic surfactants such as quaternary alkylammonium salts, amphoteric surfactants such as alkyl betaine, organic powders such as crystalline cellulose and cross-linked methylpolysiloxane, polyethylene powder, acrylic resin powder, talc, mica, Powders which may be surface-treated such as sericite, magnesium carbonate, calcium carbonate, titanium dioxide, iron oxide, navy blue, ultramarine, titanium mica, titanium sericite, silica, etc., acrylic acid / alkyl methacrylate copolymer and / or Its salt, carboxy Nyl polymers and / or salts thereof, thickeners such as xanthan gum and hydroxypropylcellulose, vitamins such as retinol, retinoic acid, tocopherol, riboflavin, pyridoxine, ascorbic acid, and ascorbic acid phosphate salts, glycyrrhizinate, glycyrrhetin, ursolic acid Active ingredients such as terpenes such as oleanolic acid, steroids such as estradiol, ethinyl estradiol and estriol, preservatives such as phenoxyethanol, parabens, hibitene gluconate, benzalkonium chloride, dimethylaminobenzoic acid esters, and cinnamon Preferred examples include ultraviolet absorbers such as acid esters and benzophenones. Of these, surfactants, synthetic polymers such as acrylic acid / alkyl methacrylate copolymers and / or salts thereof, carboxyvinyl polymers and / or salts thereof, are substantially free from the gist of the present invention. Is preferred. In addition, since the emulsified composition of the present invention has an advantage that it is susceptible to biodegradation, it has a weak preservative effect, which is a demerit of the emulsified composition. It is preferable to contain an antibacterial polyhydric alcohol such as 1,2-pentanediol, isoprene glycol, 1,2-hexylene glycol, and more preferably 1,2-pentanediol, 1,2-hexylene glycol. The preferred content of the polyhydric alcohol is 1 to 10% by weight based on the total amount of the emulsion composition. The emulsion composition of the present invention can be produced by treating these essential components and optional components according to a conventional method.
[0010]
【Example】
Hereinafter, the present invention will be described in more detail with reference to Examples, but it is needless to say that the present invention is not limited to Examples.
[0011]
<Example 1>
According to the following formulation, an emulsified composition 1 (cosmetic) of the present invention was prepared. That is, a, b, c, and d were each adjusted to 80 ° C., and b was added to a with stirring to disperse and dissolve uniformly, and then c was added with stirring to perform base exchange. Under stirring, the mixture was gradually added to emulsify the mixture, and the mixture was stirred and cooled to obtain emulsion composition 1 as an emulsion. Comparative Example 1 in which sodium alginate was simultaneously replaced with propylene glycol alginate, Comparative Example 2 in which propylene glycol alginate was replaced with alginic acid, Control Example 1 in which sodium alginate was replaced with water, and Control Example in which propylene glycol alginate was replaced with water 2. Control Example 3 in which sodium alginate and propylene glycol alginate were substituted with alginic acid was also prepared. These were evaluated for emulsifiability under a microscope and for stability in storage tests at 5 ° C, 20 ° C and 40 ° C for 2 weeks. The evaluation criteria were: ：: good, Δ: partially defective, ×: defective. Table 1 shows the results. This shows that the emulsifying composition and the stability of the emulsifying composition of the present invention are extremely good. Emulsion composition 1 was evaluated by professional panelists as having requirements for cosmetics.
0.1 part by weight of sodium alginate 1.5 parts by weight of propylene glycol alginate (Kimiloid NLSK)
1,2-hexylene glycol 5 parts by weight Water 70 parts by weight Calcium chloride 0.001 part by weight Water 13.399 parts by weight Nisqualane 5 parts by weight Glyceryl triisooctanoate 5 parts by weight
[Table 1]
<Example 2>
Emulsion compositions 2 to 4 (all cosmetics) were prepared and evaluated in the same manner as in Example 1 by changing the amount of propylene glycol alginate in Emulsion composition 1, and the effects were observed. Table 2 shows the results. From this, it is understood that the preferable content of the polyhydric alcohol ester of alginic acid is 1 to 5% by weight, more preferably 1.2 to 2% by weight, based on the total amount of the emulsified composition. Further, the emulsion compositions 2 to 4 were evaluated as having the requirements as cosmetics by evaluation by a specialized panelist.
0.1 part by weight of sodium alginate propylene glycol alginate * parts by weight (Kimiloid NLSK)
1,2-hexylene glycol 5 parts by weight Water 71.5- * parts by weight Calcium chloride 0.001 part by weight Water 13.399 parts by weight Nisqualane 5 parts by weight Glyceryl triisooctate 5 parts by weight It writes in.
[0014]
[Table 2]
<Example 3>
Emulsion compositions 5 to 7 (all cosmetics) were prepared and evaluated in the same manner as in Example 1 by changing the amount of calcium chloride in emulsion composition 1, and the effects were observed. Table 3 shows the results. Accordingly, the preferable content of the polyvalent metal root such as calcium chloride is 0.0005 to 0.25% by weight, more preferably 0 to 0.25% by weight in terms of monochloride, based on the total amount of the emulsified composition. It can be seen that the content is 0.005 to 0.2% by weight. Emulsified compositions 5 to 7 were evaluated by specialist panelists as having requirements for cosmetics.
0.1 part by weight of sodium alginate 1.5 parts by weight of propylene glycol alginate (Kimiloid NLSK)
1,2-hexylene glycol 5 parts by weight Water 70 parts by weight Calcium chloride ** parts by weight water 13.4-** parts by weight Nisqualane 5 parts by weight glyceryl triisooctanoate 5 parts by weight ** Write.
[0016]
[Table 3]
<Example 4>
Emulsion compositions 8 to 7 (all cosmetics) were prepared and evaluated in the same manner as in Example 1 except that the grade of propylene glycol alginate of emulsion composition 1 was changed, and the effects were observed. Table 4 shows the results. This indicates that any grade can be used.
0.1 parts by weight of sodium alginate 1.5 parts by weight of propylene glycol alginate (products listed in Table 4)
1,2-hexylene glycol 5 parts by weight Water 70 parts by weight Calcium chloride 0.001 part by weight 13.399 parts by weight Nisqualane 5 parts by weight Glyceryl triisooctanoate 5 parts by weight
[Table 4]
<Example 5>
The same study as in Example 4 was conducted, except that the calcium chloride of the emulsified composition 1 was replaced with another polyvalent metal chloride. It turns out that any polyvalent metal chloride can be used. It can also be seen that calcium is particularly preferred.
0.1 part by weight of sodium alginate 1.5 parts by weight of propylene glycol alginate ("Kimiloid NLSK")
1,2-hexylene glycol 5 parts by weight Water 70 parts by weight C Components listed in Table 5 0.001 parts by weight Water 13.399 parts by weight Nisqualane 5 parts by weight Glyceryl triisooctate 5 parts by weight
[Table 5]
<Example 6>
By operating in the same manner as in Example 1, an emulsified composition 18 (external medicine for skin) was prepared.
0.1 part by weight of sodium alginate 1.5 parts by weight of propylene glycol alginate (Kimiloid NLSK)
1,2-hexylene glycol 5 parts by weight Water 70 parts by weight Calcium chloride 0.001 part by weight Water 11.399 parts by weight Nisqualane 5 parts by weight Glyceryl triisooctanoate 5 parts by weight Terbinafine 2 parts by weight
【The invention's effect】
According to the present invention, it is possible to provide an emulsified composition which is suitable as an external preparation for skin and does not use a synthetic polymer or a surfactant.
Claims (6)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002369075A JP4834278B2 (en) | 2002-12-20 | 2002-12-20 | Emulsified composition based on natural products |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2002369075A JP4834278B2 (en) | 2002-12-20 | 2002-12-20 | Emulsified composition based on natural products |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2004196728A true JP2004196728A (en) | 2004-07-15 |
| JP2004196728A5 JP2004196728A5 (en) | 2006-02-23 |
| JP4834278B2 JP4834278B2 (en) | 2011-12-14 |
Family
ID=32765408
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2002369075A Expired - Fee Related JP4834278B2 (en) | 2002-12-20 | 2002-12-20 | Emulsified composition based on natural products |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP4834278B2 (en) |
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006016325A (en) * | 2004-06-30 | 2006-01-19 | Shiseido Co Ltd | Hair cosmetic |
| JP2006076900A (en) * | 2004-09-08 | 2006-03-23 | Pola Chem Ind Inc | Emulsion cosmetic |
| JP2006076898A (en) * | 2004-09-08 | 2006-03-23 | Pola Chem Ind Inc | Emulsifier type skin external preparation |
| JP2007161612A (en) * | 2005-12-12 | 2007-06-28 | Pola Chem Ind Inc | Skin care preparation for improving skin barrier function |
| WO2007148472A1 (en) * | 2006-06-19 | 2007-12-27 | Kuraray Co., Ltd. | Agent for external application to the skin having excellent stability |
| JP2008255044A (en) * | 2007-04-04 | 2008-10-23 | Pola Chem Ind Inc | External preparation for skin in the form of emulsifier type |
| JP2008266249A (en) * | 2007-04-24 | 2008-11-06 | Pola Chem Ind Inc | Emulsifier type external preparation for skin |
| JP2009225788A (en) * | 2008-02-26 | 2009-10-08 | Taisho Pharmaceutical Co Ltd | Beverage |
-
2002
- 2002-12-20 JP JP2002369075A patent/JP4834278B2/en not_active Expired - Fee Related
Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2006016325A (en) * | 2004-06-30 | 2006-01-19 | Shiseido Co Ltd | Hair cosmetic |
| JP2006076900A (en) * | 2004-09-08 | 2006-03-23 | Pola Chem Ind Inc | Emulsion cosmetic |
| JP2006076898A (en) * | 2004-09-08 | 2006-03-23 | Pola Chem Ind Inc | Emulsifier type skin external preparation |
| JP2007161612A (en) * | 2005-12-12 | 2007-06-28 | Pola Chem Ind Inc | Skin care preparation for improving skin barrier function |
| CN101528189B (en) * | 2006-06-19 | 2012-09-05 | 可东丽股份有限公司 | Agent for external application to the skin having excellent stability |
| RU2428167C2 (en) * | 2006-06-19 | 2011-09-10 | Курарей Ко., Лтд. | Preparation for external application on skin, which possesses higher stability |
| WO2007148472A1 (en) * | 2006-06-19 | 2007-12-27 | Kuraray Co., Ltd. | Agent for external application to the skin having excellent stability |
| JP5145221B2 (en) * | 2006-06-19 | 2013-02-13 | 株式会社クラレ | Skin external preparation with excellent stability |
| US8563618B2 (en) | 2006-06-19 | 2013-10-22 | Kuraray Co., Ltd. | Skin external preparation having excellent stability |
| KR101361430B1 (en) | 2006-06-19 | 2014-02-10 | 가부시키가이샤 구라레 | Skin external preparation having excellent stability |
| JP2008255044A (en) * | 2007-04-04 | 2008-10-23 | Pola Chem Ind Inc | External preparation for skin in the form of emulsifier type |
| JP2008266249A (en) * | 2007-04-24 | 2008-11-06 | Pola Chem Ind Inc | Emulsifier type external preparation for skin |
| JP2009225788A (en) * | 2008-02-26 | 2009-10-08 | Taisho Pharmaceutical Co Ltd | Beverage |
Also Published As
| Publication number | Publication date |
|---|---|
| JP4834278B2 (en) | 2011-12-14 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP5761838B2 (en) | Oil-in-water emulsified hair conditioner | |
| WO2008074675A1 (en) | Emulsions containing encapsulated fragrances and personal care compositions | |
| JP5718010B2 (en) | Oil-in-water emulsion composition | |
| JP4834278B2 (en) | Emulsified composition based on natural products | |
| JP3444366B2 (en) | Emulsion composition | |
| JP2000273016A (en) | Powder-containing aqueous cosmetic | |
| JP3558433B2 (en) | Liquid cosmetics | |
| JP4027780B2 (en) | Cosmetics for hair with no stickiness or unevenness | |
| JPH07100356A (en) | New conjugate material and emulsifying agent | |
| JP2003267830A (en) | Liquid cosmetic | |
| JP4150646B2 (en) | Skin external preparation in oil-in-water emulsifier form | |
| JP4188777B2 (en) | Emulsified composition | |
| JP4712996B2 (en) | Cosmetics | |
| JP2003055142A (en) | O/w-type cosmetic | |
| JP2004231619A5 (en) | ||
| JP2004250332A (en) | Cosmetic for cleaning | |
| JP2005306849A (en) | O/w-type cake cosmetic | |
| JP2005035947A (en) | Cosmetic for moisture retention | |
| JP2020128345A (en) | Oil-in-water emulsion composition | |
| JP2004161629A (en) | Cosmetic for hair of excellent luster quality | |
| JP2003104871A (en) | W/o/w type complex emulsion | |
| JPH0552284B2 (en) | ||
| JP4034677B2 (en) | Oil-in-water emulsified cosmetic | |
| JPH09255530A (en) | Solubilized cosmetic | |
| JP2003048814A (en) | Oil-in-water type cosmetic |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20051125 |
|
| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20051125 |
|
| RD03 | Notification of appointment of power of attorney |
Free format text: JAPANESE INTERMEDIATE CODE: A7423 Effective date: 20051125 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A821 Effective date: 20051125 |
|
| A977 | Report on retrieval |
Free format text: JAPANESE INTERMEDIATE CODE: A971007 Effective date: 20070117 |
|
| A131 | Notification of reasons for refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A131 Effective date: 20070123 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20070326 |
|
| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20080415 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080616 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20080605 |
|
| A911 | Transfer to examiner for re-examination before appeal (zenchi) |
Free format text: JAPANESE INTERMEDIATE CODE: A911 Effective date: 20080729 |
|
| A912 | Re-examination (zenchi) completed and case transferred to appeal board |
Free format text: JAPANESE INTERMEDIATE CODE: A912 Effective date: 20081031 |
|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20110808 |
|
| A01 | Written decision to grant a patent or to grant a registration (utility model) |
Free format text: JAPANESE INTERMEDIATE CODE: A01 |
|
| A61 | First payment of annual fees (during grant procedure) |
Free format text: JAPANESE INTERMEDIATE CODE: A61 Effective date: 20110926 |
|
| R150 | Certificate of patent or registration of utility model |
Ref document number: 4834278 Country of ref document: JP Free format text: JAPANESE INTERMEDIATE CODE: R150 Free format text: JAPANESE INTERMEDIATE CODE: R150 |
|
| FPAY | Renewal fee payment (event date is renewal date of database) |
Free format text: PAYMENT UNTIL: 20140930 Year of fee payment: 3 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| R250 | Receipt of annual fees |
Free format text: JAPANESE INTERMEDIATE CODE: R250 |
|
| LAPS | Cancellation because of no payment of annual fees |