JP2004018436A - Foamable bath medicine - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To obtain a foamable bath medicine having excellent storage stability to temperature and humidity. <P>SOLUTION: The foamable bath medicine is obtained by compression molding (A) an organic acid-containing acidic mixture and (B) a carboxylate-containing alkaline mixture into a granular, flaky or broken stone-like form by a dry type compression granulator, respectively, further impregnating one or more kinds of oily components selected from the group consisting of a perfume, a beautification component and a pharmacodynamic component into the granules afterward and packing the obtained two kinds of the granules into the same container. <P>COPYRIGHT: (C)2004,JPO

Description

【００４５】
［製造方法］
表１に示す処方の組成物（酸性造粒物、アルカリ性造粒物の各々）を、成形用添加剤を使用することなく、ターボ工業社製のＷＰ２３０×１２０を用いて、板状の酸性圧縮成形物及びアルカリ性圧縮成形物を調製した。次に各々を架碎整粒機を用いて、粒径４〜６ｍｍ、見かけ比重１．０の顆粒状〜碎石状の酸性造粒物及びアルカリ性造粒物を調製した。尚、香料は顆粒状〜碎石状の酸性造粒物に噴霧含浸させた。次に得られた酸性造粒物及びアルカリ性造粒物を、Ｖ型混合機を用いて、質量比１：１で混合したものを、アルミ分包に５０ｇ充填密封して実施例１の発泡性浴用剤とした。
【００４６】
比較例１
表２に示す処方の組成物を、下記の製造方法により調製し、前記保存安定性試験を行った。
【００４７】
【表２】

【００４８】
［製造方法］
表２に示す処方の組成物を、成形用添加剤を使用することなく、ターボ工業社製のＷＰ２３０×１２０を用いて、板状の圧縮成形物を調製した。次に架碎整粒機を用いて、粒径４〜６ｍｍ、見かけ比重１．０の顆粒状〜碎石状造粒物を調製した。尚、香料は顆粒状〜碎石状の造粒物に噴霧含浸させたものを、アルミ分包に５０ｇ充填密封して比較例１の発泡性浴用剤とした。
【００４９】
［保存安定性の試験結果］
実施例１の発泡性浴用剤は上記の保存条件に対して安定であり、外観の変化（発泡性浴用剤の崩落、アルミ分包の膨張）は認められず、更に炭酸ガス発生量も、２ｇの発泡性浴用剤から２３０ｃｃを測定し、新たに製造したものと同一であった。一方、比較例１の発泡性浴用剤は、アルミ分包の膨張が認められた。
【００５０】
［浴用効果］
実施例１の発泡性浴用剤約５０ｇを、約１８０Ｌの浴湯中に投入すると、微細な炭酸ガスの泡が持続的に発生した。
また実施例１の発泡性浴用剤５〜１０ｇを、約１０Ｌの湯を入れた容器の中に投入すると、手や足を浸しているうちに全身が暖まり、浴後の爽快感を味わうことができた。
【００５１】
【発明の効果】
以上記載したように、本発明は、温度や湿度に対する保存安定性が良好な発泡性浴用剤を容易に得ることができる。[0001]
TECHNICAL FIELD OF THE INVENTION
The present invention relates to an effervescent bath agent, and more particularly, to an effervescent bath agent having good storage stability against temperature and humidity.
[0002]
[Prior art]
A bath agent is generally a mixture of inorganic salts such as sodium sulfate, sodium carbonate, sodium hydrogen carbonate, etc., mixed with a fragrance, a pigment, a plant extract, an organic acid, etc. By giving an appropriate stimulus, blood circulation is activated, and fatigue recovery and metabolism are promoted. And among these bath agents, the foaming bath agent mixes carbonates and organic acids, and dissolves in the bath water to generate carbon dioxide gas, enhance the feeling of relaxation and exhilaration, and make bathing fun. There is.
[0003]
Conventionally, tablet-type foaming agents have been widely used as such a foaming bath agent. However, if moisture (moisture) is present before the bathing agent is added, a neutralization reaction between the carbonate and the organic acid occurs. In addition, there is a problem that the carbon dioxide gas is expanded and collapsed due to the generation of carbon dioxide gas to prevent the product from being produced.
[0004]
Therefore, in order to prevent such a phenomenon from occurring, various preventive measures have been taken such as blending additives for compression molding such as a binder and a stabilizer, and devising the mechanism and material of the packaging container. The product has been launched above.
[0005]
In particular, compression molding additives are essential components for tablet production, and mainly polyethylene glycol, starch, talc, magnesium oxide, magnesium stearate and the like are used. The purpose is to smooth the compression molding operation, enhance the moldability of the preparation, and keep the storage stability favorable.
[0006]
However, the additives for compression molding do not have any heat retaining effect or relaxing effect which is the original purpose of the bath agent. Further, in the foaming bath agent, there are undesired technical problems in use, such as the compression molding additive lowering the transparency of the bath water and generating a floating substance.
[0007]
In addition, tablet-type foaming bath agents are limited in terms of production. That is, in order to obtain a sufficient warm bath effect, about 50 g of a bath agent is required for one bath, and the diameter of the tablet is inevitably about 5 cm. In addition, since all components must be mixed and tableted, it cannot be manufactured with a small tableting machine used for manufacturing ordinary cold and gastrointestinal drugs, so a large special hydraulic machine must be used. There was a major problem that no one could easily manufacture.
[0008]
[Problems to be solved by the invention]
The present invention has been made under such circumstances, and an object of the present invention is to provide a foaming bath agent having good storage stability with respect to temperature and humidity. It is completely different from the conventional effervescent bath preparation for large tablets.
[0009]
In addition, the dry compression granulator described below is a compact, high-performance granulator that can be moved, and is suitable for small-scale production. However, it is also an object of the present invention to establish an optimal formulation for the performance of this machine.
[Means for Solving the Problems]
[0010]
The present inventors have thoroughly studied the performance of a dry compression granulator and have studied them thoroughly, and contain an acidic mixture containing an organic acid such as succinic acid and citric acid and a carbonate such as sodium hydrogen carbonate and sodium carbonate. The alkaline mixture is separately granulated by a dry compression granulator to prepare acidic granules and alkaline granules, and then filled in the same container to ensure storage stability against temperature and humidity. It has been found that a foaming bath agent having good properties can be obtained. Furthermore, the present inventors have found that a foaming bath agent that is more stable and easy to produce can be obtained by post-impregnating an acidic granulated product with an oil-soluble medicinal component, cosmetic component, fragrance and the like.
[0011]
The present inventors have also found that sodium bicarbonate, carbonic acid in an alkaline mixture containing succinic acid, citric acid, anhydrous sodium sulfate, and calcined sodium chloride, and carbonate in an acidic mixture containing an organic acid. Long-term in-situ experiments were conducted to show that foaming bath agents with particularly good storage stability can be obtained when sodium, anhydrous sodium sulfate, and calcined sodium chloride are blended in a specific ratio without using compression molding additives. confirmed.
[0012]
That is, the first aspect of the present invention provides a method in which an acidic mixture containing (A) an organic acid and an alkaline mixture containing (B) a carbonate are granulated, flaked, or crushed, respectively, by a dry compression granulator. The foaming bath agent is characterized by being compression-molded and filled in the same container with the two obtained granules.
[0013]
Further, the second present invention provides a method in which an acidic mixture containing (A) an organic acid and an alkaline mixture containing (B) a carbonate are granulated, flaked or crushed by a dry compression granulator. Compression molded into one or more of the obtained granules, and subsequently impregnated one or more of oily components selected from the group consisting of fragrances, cosmetic ingredients, and medicinal ingredients into one or both of the obtained granules; The foaming bath agent is characterized by filling the same granules in the same container.
[0014]
According to a third aspect of the present invention, the acidic mixture containing (A) an organic acid and the alkaline mixture containing (B) a carbonate do not contain a compression molding additive. 3. The foaming bath agent according to 1 or 2.
[0015]
According to a fourth aspect of the present invention, (A) the acidic mixture containing an organic acid and (B) the alkaline mixture containing a carbonate further contain anhydrous sulfate and / or anhydrous sodium chloride. The foaming bath agent according to any one of claims 1 to 3, characterized in that:
[0016]
Further, the fifth invention is characterized in that (A) the acidic mixture containing an organic acid is composed of 20 to 50% by mass of succinic acid, 20 to 50% by mass of citric acid, 10 to 50% by mass of anhydrous sodium sulfate based on the total amount of the acidic mixture. The foaming agent for foaming bath according to any one of claims 1 to 4, comprising 40% by mass and 10 to 40% by mass of calcined sodium chloride.
[0017]
In a sixth aspect of the present invention, the alkaline mixture containing (B) carbonate is 20 to 60% by mass of sodium hydrogen carbonate, 10 to 40% by mass of sodium carbonate, 10% by mass of anhydrous sodium sulfate, based on the total amount of the alkaline mixture. The foaming bath agent according to any one of claims 1 to 5, wherein the foaming bath agent contains 1 to 30% by mass and 10 to 30% by mass of calcined sodium chloride.
[0018]
BEST MODE FOR CARRYING OUT THE INVENTION
Hereinafter, the configuration will be described in detail.
[0019]
The present invention is characterized by separately preparing an acidic granulated product and an alkaline granulated product, and then mixing both, so that there is little chance of contact between the two, and a very stable foaming bath agent can be obtained. it can.
[0020]
The acidic granules and the alkaline granules are preferably mixed in a mass ratio of 2: 3 to 3: 2, and mixed at a mass ratio of 1: 1 so that the pH becomes neutral. Is particularly preferred.
[0021]
Examples of the (A) organic acid used in the present invention include citric acid, malic acid, tartaric acid, fumaric acid, succinic acid, malonic acid, maleic acid, pyrrolidone carboxylic acid, adipic acid, glutaric acid, benzoic acid, salicylic acid, Glycolic acid, lactic acid, glyceric acid, pyruvic acid and the like can be mentioned. In particular, a combination of succinic acid and citric acid is preferable because the amount of carbon dioxide gas generated is larger.
[0022]
The amount of the organic acid (A) used in the present invention is preferably 40 to 100% by mass (hereinafter simply abbreviated to%), based on the total amount of the acidic mixture in which the organic acid is incorporated. If the amount of the organic acid is less than 40%, the amount of carbon dioxide generated may not be sufficient.
Further, when succinic acid and citric acid are used in combination as the organic acid (A), it is particularly preferable that succinic acid is 20 to 50% and citric acid is 20 to 50% based on the total amount of the acidic mixture in which it is blended.
[0023]
Examples of the (B) carbonate used in the present invention include sodium bicarbonate, sodium carbonate, sodium sesquicarbonate, magnesium carbonate, potassium carbonate, potassium bicarbonate, and ammonium carbonate. And sodium carbonate are preferable because the amount of carbon dioxide gas generated is larger.
[0024]
The amount of the carbonate (B) used in the present invention is preferably 30 to 100%, based on the total amount of the alkaline mixture in which the carbonate is mixed. If the amount of the carbonate is less than 30%, the amount of carbon dioxide generated may not be sufficient.
In the case where sodium carbonate and sodium carbonate are used in combination as (B) carbonate, it is particularly preferable to set sodium hydrogencarbonate to 20 to 60% and sodium carbonate to 10 to 40% based on the total amount of the alkaline mixture in which it is blended. preferable.
[0025]
Further, in the present invention, a robust porous granulated product can be obtained by further combining and combining anhydrous sulfate and anhydrous sodium chloride.
[0026]
The anhydrous sulfate used in the present invention may be one usually used in cosmetics, but is preferably anhydrous sodium sulfate, particularly anhydrous sodium sulfate of 100 to 140 mesh is convenient at the time of production, It is preferable because the effect is sufficiently enhanced.
[0027]
The anhydrous sodium chloride used in the present invention may be one usually used for cosmetics, but from the viewpoint of storage stability, calcined sodium chloride is preferred. The calcined sodium chloride is more preferably one obtained by baking sodium chloride at 140 ° C. for 90 minutes, pulverizing, and passing through a sieve so that the 140 mesh becomes 90% or more.
[0028]
The dry compression granulator used in the present invention is a small portable machine that compresses and forms raw materials such as chemicals and foods between two rotating rolls. A typical example thereof is a compacting machine (for example, WP230 × 120 manufactured by Turbo Kogyo KK).
[0029]
The compacting machine compresses the powder raw material between two rolls rotating at the same speed by pressing into each other, and molding, and forms a smooth roll, a corrugated roll, or a pattern without engraving pockets on the outer peripheral surface of the roll. By using a chopped roll or the like, it is formed into a plate shape (flakes), and then the flakes are crushed by a crushing and sizing machine and further sieved to obtain flakes, granules, or Crushed granules can be obtained. Particularly, a granulated product having a particle size of 4 to 6 mm is preferable. By adjusting the molding pressure within the range of 0.01 to 5 t / cm ² , a foaming bath agent having particularly excellent storage stability can be obtained.
[0030]
The (A) acidic mixture containing an organic acid and (B) an alkaline mixture containing a carbonate are compressed into granules, flakes, or crushed stones by the dry compression granulator described above. It is formed into acidic granules and alkaline granules, but (A) an acidic mixture containing an organic acid and (B) an alkaline mixture containing a carbonate do not contain a compression molding additive. It is preferable that
[0031]
Additives for compression molding (binders, lubricants, stabilizers) are added to smooth the compression molding operation, enhance the moldability of the formulation, and maintain good storage stability of the granules. The present invention relates to casein, sodium carboxymethylcellulose, water-soluble gelatin, pectin, starch, methylcellulose, ethylcellulose, sodium alginate, polyvinyl alcohol, polyvinylpyrrolidone, polyvinylmethylether, polyethylene glycol, karaya gum, locust bean gum. Binders, such as tragacanth gum, carrageenan, carboxyvinyl polymer, acacia gum, agar, dextrin, cyclodextrin, sorbitol, reduced maltose syrup, lubricating agents such as magnesium stearate, calcium stearate, and talc Magnesium oxide, not used at all stabilizers such as sodium aluminate.
[0032]
The acidic granules and the alkaline granules of the present invention are both extremely robust and porous, and can be impregnated with oily components such as fragrances, cosmetic ingredients, and medicinal ingredients, and are more stable during storage. There is no need for excessive moisture protection. In particular, it is more preferable to impregnate the acidic granules in terms of storage stability.
[0033]
As a method of post-impregnation, after preparing an acidic granulated product or an alkaline granulated product, a fixed amount of an oily component is spray-mixed to adhere the oily component to the surface of the granulated product.
[0034]
As the fragrance used in the present invention, lavender oil, jasmine oil, rose oil, lemon oil, orange oil, peppermint oil, thyme oil, shobu oil, hiba oil, hinoki oil, rose oil, eucalyptus oil, camphor, peppermint oil, Natural or synthetic flavors such as spearmint oil, geraniol, citronellol and the like can be mentioned.
[0035]
Cosmetic components used in the present invention include castor oil, olive oil, grape seed oil, camellia oil, jojoba oil, avocado oil, soybean oil, almond oil, coconut oil, palm oil, rice bran oil, rice germ oil, sesame oil, turtle oil Oils and fats such as mink oil; proteins and derivatives thereof such as collagen and keratin; amino acids and derivatives thereof such as sodium glutamate and trimethylglycine; and squalane.
[0036]
The medicinal ingredients used in the present invention include glycyrrhizic acid, glycyrrhetinic acid, salicylic acid and derivatives thereof, allantoin, hinokitiol, vitamin E and the like.
[0037]
Since the foaming bath agent of the present invention has extremely good storage stability, it can be used in containers of various shapes and materials, including commonly used sachets and resin bottles, without using excessive moisture-proof measures. The cost can be reduced.
[0038]
The present invention can be used for dissolving or dispersing the active ingredient in water by foaming, in addition to the foaming bath agent, for example, a face wash, a partial bath for fingers and feet, a gargle, a cleaning agent, a deodorant and a fragrance. Widely applicable to applications such as
【Example】
[0039]
Hereinafter, the present invention will be described with reference to examples, but the present invention is not limited to these examples. The test method of storage stability and the production method used in this example are shown below. In addition, the numerical value in a table | surface shows a compounding quantity (mass%).
[0040]
[Test method for storage stability]
After 50 g of the foaming bath agent of the examples and comparative examples were sealed in an aluminum package and stored under the following conditions, the newly manufactured product and the appearance (whether or not the foaming agent collapsed, the expansion of the aluminum package) Presence / absence) and the amount of generated carbon dioxide.
[0041]
<Storage conditions>
18 months in a room with an average temperature of 25 ° C for 12 months in a thermostat with a temperature of 45 ° C and 80% humidity for 6 months in a thermostat at 55 ° C and 80% humidity
<Method of measuring the amount of generated carbon dioxide>
At the bottom of a large 300 mL syringe, 2 g of the crushed foaming bath agent is put, and 10 mL of hot water is put into another small syringe and connected, and hot water is injected into the large syringe to generate carbon dioxide gas. Since the generated carbon dioxide gas naturally pushes up the piston, the scale when the sample was completely dissolved was read to determine the amount of generated carbon dioxide gas.
[0043]
Example 1
Compositions having the formulations shown in Table 1 were prepared by the following production methods and subjected to the storage stability test.
[0044]
[Table 1]

[0045]
[Production method]
Each of the compositions (each of the acidic granulated product and the alkaline granulated product) having the formulation shown in Table 1 was subjected to plate-shaped acidic compression using WP230 × 120 manufactured by Turbo Kogyo without using a molding additive. A molded article and an alkaline compression molded article were prepared. Next, using a crushing and sizing machine, a granular to crushed acidic granulated product and an alkaline granulated product having a particle size of 4 to 6 mm and an apparent specific gravity of 1.0 were prepared. The flavor was spray-impregnated into granular to crushed acidic granules. Next, the obtained acidic granulated product and alkaline granulated product were mixed at a mass ratio of 1: 1 using a V-type mixer, and 50 g was sealed in an aluminum package and sealed. It was used as a bath agent.
[0046]
Comparative Example 1
Compositions having the formulations shown in Table 2 were prepared by the following production methods and subjected to the storage stability test.
[0047]
[Table 2]

[0048]
[Production method]
A plate-shaped compression molded product was prepared from the composition having the formulation shown in Table 2 using WP230 × 120 manufactured by Turbo Kogyo without using a molding additive. Next, using a crushing and sizing machine, granular to crushed stone granules having a particle size of 4 to 6 mm and an apparent specific gravity of 1.0 were prepared. The fragrance was spray impregnated into granules from granules to crushed stones, and 50 g was filled in an aluminum package and sealed to obtain a foaming bath agent of Comparative Example 1.
[0049]
[Test results of storage stability]
The foaming bath agent of Example 1 was stable under the above storage conditions, no change in appearance (collapse of the foaming bath agent, expansion of the aluminum package) was observed, and the amount of carbon dioxide gas generated was 2 g. Of the foaming bath agent was measured, and the result was the same as that of a freshly manufactured bath agent. On the other hand, in the foaming bath agent of Comparative Example 1, expansion of the aluminum package was observed.
[0050]
[Bath effect]
When about 50 g of the foaming bath agent of Example 1 was introduced into about 180 L of bath water, fine carbon dioxide gas bubbles were continuously generated.
Also, when 5 to 10 g of the foaming bath preparation of Example 1 is put into a container containing about 10 L of hot water, the whole body warms while the hands and feet are immersed, and the refreshing feeling after bathing can be enjoyed. Was.
[0051]
【The invention's effect】
As described above, according to the present invention, a foaming bath agent having good storage stability against temperature and humidity can be easily obtained.

Claims (6)

(A) An acidic mixture containing an organic acid and (B) an alkaline mixture containing a carbonate are each compression-molded into granules, flakes, or crushed stones by a dry compression granulator and obtained. A foaming bath agent characterized by filling the same two kinds of granules in the same container. (A) An acidic mixture containing an organic acid and (B) an alkaline mixture containing a carbonate are each compression-molded into granules, flakes, or crushed stones by a dry compression granulator, and further, a fragrance, Foaming, characterized in that one or more oily components selected from the group consisting of a cosmetic component and a medicinal component are subsequently impregnated, and the obtained two types of granules are filled in the same container. Bath agent. 3. The foamable bath according to claim 1, wherein (A) the acidic mixture containing an organic acid and (B) the alkaline mixture containing a carbonate do not contain a compression molding additive. Agent. The acidic mixture containing (A) an organic acid and the alkaline mixture containing (B) a carbonate further contain anhydrous sulfate and / or anhydrous sodium chloride. 4. The foamable bath agent according to any one of the above items 3. (A) An acidic mixture containing an organic acid is composed of 20 to 50% by mass of succinic acid, 20 to 50% by mass of citric acid, 10 to 40% by mass of anhydrous sodium sulfate, and calcined sodium chloride based on the total amount of the acidic mixture. The agent for a foamable bath according to any one of claims 1 to 4, wherein the agent comprises 10 to 40% by mass. (B) An alkaline mixture containing a carbonate is, based on the total amount of the alkaline mixture, 20 to 60% by mass of sodium hydrogen carbonate, 10 to 40% by mass of sodium carbonate, 10 to 30% by mass of anhydrous sodium sulfate, and calcined chloride. The foaming bath agent according to any one of claims 1 to 5, which contains 10 to 30% by mass of sodium.