JP2003342146A - Skin care preparation for sensitive skin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a preparation hardly exhibiting transitory irritation while having resistance to microbial contamination without using an antiseptic agent such as parabens conventionally used for general purpose. <P>SOLUTION: The skin care preparation such as a cosmetic contains (1) 1,2- hexylene glycol and (2) polyhydric alcohols such as 1,3-butanediol, 1,2- pentanediol, isopropylene glycol, propylene glycol, polypropylene glycol and dipropylene glycol. Preferably, the skin care preparation does not contain the conventional antiseptic agent such as the paraben. <P>COPYRIGHT: (C)2004,JPO

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a skin external preparation useful for cosmetics and the like, and more particularly to a skin external preparation suitable for persons with sensitive skin.

[0002]

2. Description of the Related Art The skin is
It exhibits its water retention function and barrier function, and protects the living body from external stimuli. If these functions are not fully exerted, it is said that the skin becomes sensitive to external stimuli such as chemical stimuli and slight physical stimuli. In order to fully exert these functions, a solid keratin structure and the amount and balance of lipids and water are important. From this point of view, the replenishment of the oily component and the aqueous component is the point of care for the skin. In such a supply,
Since both can be supplied by using an emulsion composition, such an emulsion composition dosage form is widely used. Such an emulsified composition dosage form contains a large amount of an assimilating oil agent and water necessary for the growth of fungi, and is therefore a favorable environment for the growth of microorganisms. In other words, the dosage form is susceptible to microbial contamination. Parabens such as methylparaben are often used as preservatives in order to prevent the growth of such microorganisms and prevent microbial contamination. However, such parabens have a transient stimulant-expressing action, and it has been difficult for people who are said to have sensitive skin to use external preparations for skin such as cosmetics containing such parabens. Other antiseptics used in the external preparation for skin, such as benzalkonium chloride and hibitene gluconate, also have the problems of transient irritation and mucosal damage. Therefore, it has been desired to develop a means for preventing microbial contamination, which can replace the preservatives that have been widely used until now such as parabens.

On the other hand, 1,2-hexylene glycol, 1,3-butanediol, 1,2-pentanediol, isoprene glycol, propylene glycol,
Polyhydric alcohols such as polypropylene glycol or dipropylene glycol have already been used as moisturizers in external skin preparations such as cosmetics, but 1) 1,2-hexylene glycol and 2) 1,2-hexylene. It is not contained in a combination of polyhydric alcohols other than glycol, and such a combination improves antiseptic and moisturizing properties,
It has not been known at all that an external preparation for skin that can be used safely by people with sensitive skin can be provided.

[0004]

SUMMARY OF THE INVENTION The present invention has been made under such circumstances and has resistance to microbial contamination without using preservatives such as parabens which have been widely used until now. It is an object of the present invention to provide a preparation which does not exhibit transient stimulation.

[0005]

In view of such circumstances, the present inventors have a transient resistance while having resistance to microbial contamination without using a preservative such as parabens which has been widely used until now. As a result of intensive studies in search of a drug that does not cause irritation, 1) 1,2-hexylene glycol and 2) 1,3-
It was found that such a preparation can be obtained by incorporating a polyhydric alcohol such as butanediol, 1,2-pentanediol, isoprene glycol, propylene glycol, polypropylene glycol or dipropylene glycol into a skin external preparation, The invention was completed. That is, the present invention relates to the techniques described below. (1) 1) 1,2-hexylene glycol and 2) 1,2
-A skin external preparation characterized by containing a polyhydric alcohol other than hexylene glycol. (2) The polyhydric alcohol other than 1,2-hexylene glycol is 1,3-butanediol, 1,2-pentanediol, isoprene glycol, propylene glycol, polypropylene glycol or dipropylene glycol. The external preparation for skin according to (1). (3) The external preparation for skin according to (1) or (2), which further contains phenoxyethanol. (4) Cosmetics, (1) to (3)
The external preparation for skin according to any one of items. (5) For sensitive skin, (1) to
(4) The external preparation for skin according to any one of items. Hereinafter, the present invention will be described in more detail.

(1) 1,2-Hexylene glycol which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention contains 1,2-hexylene glycol as an essential component. 1,2-Hexylene glycol has a moisturizing effect and, at the same time, exhibits very little transient irritation sensation found in conventional preservatives such as parabens. As the 1,2-hexylene glycol, those already used as raw materials for cosmetics can be used. This is an external preparation for skin of the present invention, which inhibits the growth of microorganisms, moisturizes the skin, moisturizes the skin, strengthens the skin barrier function, and enhances the resistance to external stimuli. Exert. Further, since such a component has almost no raw material odor, it can be processed into a skin external preparation such as a cosmetic without perfume and the like, and thus it is suitable for preparation of a skin external preparation for humans who is sensitive to a fragrance or the like. In the external preparation for skin of the present invention, the preferable content of 1,2-hexylene glycol varies depending on the dosage form.
To 20% by weight, more preferably 1 to 10% by weight
Is. If this is too small, it acts on microorganisms and moisturizes the skin. This is because the protective action may not be exerted in some cases, and when it is too large, the action which is unfavorable to the formulation stability such as breaking the emulsion structure or gel structure may be exhibited.

(2) Polyhydric alcohol which is an essential component of the external preparation for skin of the present invention The external preparation for skin of the present invention contains a polyhydric alcohol other than 1,2-hexylene glycol as an essential component. As such polyhydric alcohols other than 1,2-pentanediol, polyhydric alcohols used in external preparations for skin such as cosmetics can be used without particular limitation.
Specifically, 1,3-butanediol, 1,2-pentanediol, isoprene glycol, propylene glycol, polypropylene glycol, dipropylene glycol, glycerin, diglycerin, sorbitol, maltitol and the like can be preferably exemplified, and 1,3 -Butanediol, 1,2-pentanediol, isoprene glycol, propylene glycol, polypropylene glycol, and dipropylene glycol are particularly preferable. These may contain only one kind, or may contain two or more kinds in combination. The total content of the polyhydric alcohol is preferably 1 to 20% by weight based on the total amount of the skin external preparation. This is because if it is too large, the emulsifying property may be impaired, and if it is too small, the properties of moisturizing property and antiseptic property may not be exhibited.

(3) External preparation for skin of the present invention The external preparation for skin of the present invention contains 1,2-hexylene glycol and a polyhydric alcohol other than 1,2-hexylene glycol as described above. Is characterized by. Here, in the present invention, the external preparation for skin means a general term for external preparations such as cosmetics, external medicine for skin, and bactericidal / disinfectant for external skin. The external preparation for skin of the present invention can be applied to any of these, but it is preferably applied to cosmetics due to its mild characteristics, and particularly preferably applied to cosmetics for sensitive skin. The external preparation for skin of the present invention may contain, in addition to the above-mentioned essential components, any components usually used in external preparations for skin. Examples of such optional components include hydrocarbons such as squalane, liquid paraffin, and solid paraffin, silicones that are not essential components such as dimethicone and femethicone, esters such as jojoba oil and gay wax, stearic acid and olein. Fatty acids such as acids, higher alcohols such as behenyl alcohol and cetanol, oleyl alcohol, triglycerides such as beef tallow and olive oil, stearic acid monoglyceride, sorbitan sesquioleate, polyoxyethylene sorbitan monooleate,
Nonionic surfactants such as polyoxyethylene stearate, anionic surfactants such as sodium lauryl stearate, cationic surfactants such as quaternary alkyl ammonium salts, powders such as crystalline cellulose, carboxyvinyl polymers Salt, acrylic acid / methacrylic acid (C10
30) salts of alkyl copolymers, salts of polyacrylic acid,
Preferable examples include bentonite, thickeners such as xanthan gum and hydroxypropyl cellulose, active ingredients such as vitamins and glycyrrhizin. Among these, a particularly preferable component for the external preparation for skin of the present invention is phenoxyethanol, which has extremely little transient irritation and can improve the antiseptic effect of the polyhydric alcohol having the constitution of the present invention. The preferred content of such components is from 0.05 to
It is 5% by weight, more preferably 0.1 to 1% by weight. This is because if the amount is too small, the antiseptic effect may not be obtained in some cases, and if the amount is too large, the effect may peak and the stability and the degree of prescription freedom may be impaired. The external preparation for skin of the present invention can be produced by treating the above-mentioned essential components and optional components according to a conventional method.

[0009]

The present invention will be described in more detail with reference to the following examples, but only the examples according to the present invention will be described.
It goes without saying that it is not limited.

<Example 1> According to the following formulation, a cosmetic as an external preparation for skin of the present invention was prepared. That is, a,
The ingredients of (ii) were heated at 80 ° C., (ii) was gradually added to (i) to neutralize, and the mixture was cooled with stirring to obtain a lotion. At the same time, as Comparative Example 1, 1,2-hexylene glycol was replaced with 1,3-butanediol, and as Comparative Example 2, 1,3
As Control Example 1, the one obtained by substituting 1,2-hexylene glycol for butanediol was prepared by substituting water for 1,2-hexylene glycol, and the one substituting water for 1,3-butanediol. It was made. Using these lotions, the backs of 6 Hartley white guinea pigs in a group were shaved and stripped twice with gum tape 2 cm
0.01 ml was applied to a site of 2 cm × 2 cm, and a patch plaster impregnated with 0.01 ml of a 1% lactic acid aqueous solution was applied thereto, and closed patch was applied for 24 hours. One hour after the removal of the patch, the skin reaction was evaluated by the Draize standard (++; reaction with edema, +; reaction with clear erythema, ±; reaction with unclear erythema, −; no reaction). The results are shown in Table 1.
Shown in. From this, it is clear that the lotion, which is the external preparation for skin of the present invention, suppresses the irritation of lactic acid, which is a stimulant, to the skin by the protective film. B Carboxyvinyl polymer 1% aqueous solution 6 parts by weight Carbopol 1382 1% aqueous solution 5 parts by weight (acrylic acid / methacrylic acid (C10-30) alkyl) quince extract 0.1 parts by weight 1,3-butanediol 3 parts by weight 1 , 2-hexylene glycol 3 parts by weight water 77.4 parts by weight 10% potassium hydroxide aqueous solution 5.5 parts by weight * Details are shown in Table 1.

[0011]

[Table 1]

<Example 2> The above-mentioned Example 1, Comparative Example 1,
In addition to 2, Control Examples 1 and 2, Control Example 3 was also prepared in which 1,2-hexylene glycol and 1,3-butanediol of Example 1 were both replaced with water, and the antiseptic effect thereof was investigated. As for the antiseptic effect, after pre-culturing 20 ml of these cosmetics, the bacterial cells or conidia are 1 × 10 ⁶ cells / m in PBS.
A bacterial solution was added to give 1 (final concentration), 20 μl of this was seeded on a tryptosome agar (TSA) medium and a Sabouraud agar (SDA) medium, and cultured at 35 ° C. for 24 to 48 hours,
The number of colonies was counted. The results are shown in Table 2 as the number of colonies. From this, it is understood that the cosmetic of the present invention has excellent antiseptic properties. Further, it is understood that the cosmetics as the external preparation for skin of the present invention has an excellent antiseptic effect due to the combined effect of 1,2-hexylene glycol and polyhydric alcohol.

[0013]

[Table 2]

<Example 3> The following cosmetics were prepared in the same manner as in Example 1 and examined in the same manner. At the same time, as Comparative Example 3, 1,3-butanediol of Example 3 was substituted with 1,2-hexylene glycol, and as Comparative Example 4, 1,2-hexylene glycol was substituted with 1,3-butanediol. The thing was produced. B Carboxy vinyl polymer 1% aqueous solution 6 parts by weight Carbopol 1382 1% aqueous solution 5 parts by weight (acrylic acid / methacrylic acid (C10-30) alkyl) quince extract 0.1 parts by weight Component 1 * 0.1 parts by weight 1, 3-Butanediol 3 parts by weight 1,2-hexylene glycol 3 parts by weight Water 77.3 parts by weight 10% potassium hydroxide 10% aqueous solution 5.5 parts by weight * Details are shown in Table 3.

[0015]

[Table 3]

<Example 6> Examples 3 to 5 and Comparative Examples 3 and 4
The sample was evaluated in the same manner as in Example 2. The results are shown in Table 4. It is understood that all of the external preparations for skin of the present invention have an excellent antiseptic action.

[Table 4]

<Embodiments 7 to 15> Similar to the above embodiments,
A cosmetic, which is the external preparation for skin of the present invention, was prepared according to the following formulation. These were also evaluated on guinea pig-damaged skin in the same manner. B Carboxyvinyl polymer 1% aqueous solution 6 parts by weight Carbopol 1382 1% aqueous solution 5 parts by weight (acrylic acid / methacrylic acid (C10-30) alkyl) quince extract 0.1 parts by weight Sodium coco PG-dimonium chloride phosphate 0.1 Parts by weight Polyhydric alcohol ** 3 parts by weight 1,2-hexylene glycol 3 parts by weight Water 77.3 parts by weight 10% potassium hydroxide aqueous solution 5.5 parts by weight ** Details are shown in Table 6.

[0018]

[Table 5]

<Example 16> The preservative effect of the cosmetics of Examples 7 to 15 was examined in the same manner as in Example 2. The results are shown in Table 6. From this, it is understood that all the cosmetics of the present invention have excellent antiseptic properties.

[0020]

[Table 6]

<Example 15> According to the formulation shown below,
An external preparation for skin of the present invention, an undermake-up cosmetic and 1,2-hexylene glycol of 1,3
-Comparative Example 5 in which butanediol was substituted was prepared. That is, the ingredients a, b, and c are heated at 80 ° C., and gradually added to a to emulsify, and then c is added and neutralized, and the particles are adjusted with a homogenizer, and then stirred and cooled. Then, I got under makeup cosmetics. People who easily feel irritation in the foundation using this makeup cosmetics 1
For 4 persons, the right half face was treated with undermake, which is the external preparation for skin of the present invention, and then the foundation was applied, and the left half face was treated with the under make-up of Comparative Example 4, and then the foundation was applied. I was asked to. After having been used for one week like this, regarding the degree of appearance of irritation of the foundation, the right one is less likely to feel irritation, the left and right does not change, and the left is less likely to feel irritation I got an answer. The result is that all 14 people answered that the right side is less likely to feel irritation (it is less likely to feel irritation when using undermakeup, which is the skin external preparation of the present invention), which is the skin external preparation of the present invention. The effect of the undermakeup cosmetics as a protective film was confirmed. Also,
The undermake-up cosmetic composition of the present invention showed no colony formation against any bacteria in the above-mentioned preservative test.

[0022] (Undermakeup cosmetics of the present invention) I 0.1 parts by weight of cetanol Jojoba oil 0.5 parts by weight Hazelnut oil 0.1 parts by weight Olive oil 0.1 parts by weight Cetyl 2-ethylhexanoate 4 parts by weight Squalane 5 parts by weight Tocopherol 0.1 parts by weight Paraben 0.1 parts by weight Phenoxyethanol 0.1 parts by weight Polyoxyethylene stearate 0.6 part by weight Glyceryl monostearate 3 parts by weight Diglyceryl monooleate 0.5 part by weight Iris foil (red) 1 part by weight Spherical acrylic resin powder 4 parts by weight Methyl siloxane network polymer 2 parts by weight "Silicone 9028J" 12 parts by weight (High degree of polymerization dimethylpolysiloxane; manufactured by Shin-Etsu Chemical) Phospholipid PTC 0.5 parts by weight Phospholipid CDM 0.5 part by weight B Carboxyvinyl polymer 1% aqueous solution 10 parts by weight "Pemren TR-1" 1% aqueous solution 1 part by weight (Acrylic acid / methacrylic acid (C10-30) alkyl copolymer) Quince extract 0.1 parts by weight 1,2-hexylene glycol 6 parts by weight 2 parts by weight of isoprene glycol Water 51.2 parts by weight Ha 10% aqueous solution of sodium hydroxide 5.5 parts by weight

[0023] (Comparative example 5) I 0.1 parts by weight of cetanol Jojoba oil 0.5 parts by weight Hazelnut oil 0.1 parts by weight Olive oil 0.1 parts by weight Cetyl 2-ethylhexanoate 4 parts by weight Squalane 5 parts by weight Tocopherol 0.1 parts by weight Paraben 0.1 parts by weight Phenoxyethanol 0.1 parts by weight Polyoxyethylene stearate 0.6 part by weight Glyceryl monostearate 3 parts by weight Diglyceryl monooleate 0.5 part by weight Iris foil (red) 1 part by weight Spherical acrylic resin powder 4 parts by weight Methyl siloxane network polymer 2 parts by weight "Silicone 9028J" 12 parts by weight (High degree of polymerization dimethylpolysiloxane; manufactured by Shin-Etsu Chemical) Phospholipid PTC 0.5 parts by weight Phospholipid CDM 0.5 part by weight B Carboxyvinyl polymer 1% aqueous solution 10 parts by weight "Pemren TR-1" 1% aqueous solution 1 part by weight (Acrylic acid / methacrylic acid (C10-30) alkyl copolymer) Quince extract 0.1 parts by weight 1,3-butanediol 6 parts by weight 2 parts by weight of isoprene glycol Water 51.2 parts by weight Ha 10% aqueous solution of sodium hydroxide 5.5 parts by weight

<Example 16> According to the following formulation,
A steroid agent (external skin drug), which is the external skin preparation of the present invention, was prepared. That is, each of the prescription ingredients a, b, and c was heated to 70 ° C., gradually added to a, emulsified, and c was gradually added to and neutralized to obtain a steroid agent. Since this product had no transient irritation due to parabens, it was less irritating, and colony formation was not observed in all bacterial species in the above antiseptic test. B Light liquid paraffin 5 parts by weight Cetanol 2 parts by weight Polyoxyethylene (20) cetyl ether 1 part by weight Phospholipid PTC 0.2 parts by weight Phospholipid CDM 0.3 parts by weight Beclomethasone 1 part by weight Roisoprene glycol 3 parts by weight 1,2-Pentanediol 4 parts by weight 1,2-hexylene glycol 1 part by weight 1% carboxyvinyl polymer aqueous solution 5 parts by weight 1% pemulene TR-2 aqueous solution 20 parts by weight water 35 parts by weight 10% potassium hydroxide aqueous solution 2 .5 parts by weight Water 20 parts by weight

[0025]

EFFECTS OF THE INVENTION According to the present invention, it is possible to provide a preparation which has resistance to microbial contamination but does not develop transient irritation without using preservatives which have been widely used until now such as parabens. You can

Front page continuation (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 31/085 A61K 31/085 31/765 31/765 A61P 17/02 A61P 17/02 17/16 17/16 F term (Reference) 4C083 AA112 AA122 AB032 AC022 AC072 AC111 AC112 AC121 AC122 AC171 AC172 AC352 AC402 AC422 AC482 AC902 AD041 AD042 AD092 AD152 AD572 CC01 CC02 CC03 DD22 DD23 EE01 EE06 EE07 EE10 EA10 NA03 MA06 NA28 MA06 NA02 MA06 NA02 MA02 NA02 MA02 MA02 NA02 MA02 MA02 MA02 NA02 MA02 MA02 NA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 NA02 MA02 MA02 MA02 MA02 NA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 MA02 AA01 AA02 CA05 CA07 CA22 CA27 KA01 MA02 MA03 MA04 MA29 MA48 MA83 NA03 NA06 NA14 ZA89 ZA90

Claims (5)

[Claims] 1. A skin external preparation containing 1) 1,2-hexylene glycol and 2) a polyhydric alcohol other than 1,2-hexylene glycol. 2. The polyhydric alcohol other than 1,2-hexylene glycol is 1,3-butanediol, 1,2-pentanediol, isoprene glycol, propylene glycol, polypropylene glycol or dipropylene glycol. The external preparation for skin according to claim 1. 3. The external preparation for skin according to claim 1, further comprising phenoxyethanol. 4. The external preparation for skin according to any one of claims 1 to 3, which is a cosmetic. 5. The external preparation for skin according to claim 1, which is for sensitive skin.