JP2003342122A - Skin care preparation - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a skin care preparation which is compatible with the skin and can exhibit a high skin moisture-retaining effect, a high skin-beautifying effect and a high skin roughness-improving effect. <P>SOLUTION: This skin care preparation contains an extract of Chamaenerion angustifolium (L.) Scop. or Epilobium angustifolium L., and an extract of one or more plants selected from Calendula officinalis L., Petroselinum crispum (Mill.), Melissa officinalis L, Tussilago farfara L., Althaea officinalis L., Aesculus turbinata Blume or Aesculus hippocastanum L., Daucus carota L., Potentilla tormentilla, Hypericum erectum Thunb. or Hypericum perforatum L., Salvia officinalis L., Cucumis sativus L., Foeniculum vulgare Miller, Sambucus nigra L., Arnica montana L., Ononis spinosa L., Geranium nepalense Sweet. var. thunbergii (Sieb. et Zucc.) Kudo, Carthamas tinctorius L., Ophelia japonica (Schult.) Griseb., Saponaria officinalis L., Apium graveloens L. var. dulce (Mill.) Pers., Melilotuis officinalis L., Luffa cylindrica (L.) Roem, Saxifraga stolonifera Meerb., Paeonia suffruticosa Andr., Malva sylvestris L., Hamamelis virginiana L., Ziziphus jujuba Mill., Coptis japonica (Thunb.) Makino, Paeonia lactiflora Pall., Angelica acutiloba (Sieb. et Zucc.) Kitagawa, Cnidium officinale Malino, Asiarum sieboldi (miq.) F. Maekawa, Scutellaria baicalensis Georgi, Uncaria gambir (Hunt) Rocb., Poria cocos (Fr.) Wolf, Rehmannia glutinosa (Gaertn.) Libosch., Cinnamomi cassia Presl., Phellodendron amurense Pupr., Phellodendron amurense Pupr., Curcuma domestica Valet., Syzygium aromaticum (L.) Merril et Perry, Artemisia princeps Pamp., Zingiber officinale Rosc., Ganoderma lucidum (Leyss. ex Fr.) Karst, Coix lachryma-jobi L., Prunus armeniaca L., Prunus persica (L.) Batsch, Citrus junos Sieb. et Tanaka, Pueraria lobata (Willd.) Ohwi, Citrus unshiu Marcovitch, and Cuminum cyminum L., and fungi. <P>COPYRIGHT: (C)2004,JPO

Description

DETAILED DESCRIPTION OF THE INVENTION [0001] TECHNICAL FIELD The present invention relates to an extract of Spodoptera litura
And specific plant and fungal extracts in combination
It is easy to fit into the skin and has high skin moisturizing effect and beauty
An external preparation for skin that can exhibit skin effects and
I do. [0002] 2. Description of the Related Art Conventionally, many kinds of medicinal plants and the like
Plant extracts have been used in skin external preparations (Flegra
Journal, Special Issue No. 1, 1979
Magazine, Extra Edition No. 6, 1986). In recent years, nature-oriented
In response to the growing plant orientation due to animal welfare,
There is an increasing tendency to seek active ingredients from plant extracts. [0003] However, plant extracts are diverse.
Has an effect, but generally not so strong
In many cases, skin external preparations
Incorporation of the resulting amount of plant extract may cause undesirable
Color or odor is observed, or formulation stability is reduced
There was something to do. Works with multiple plant extracts
Attempts have been made to enhance the fruit, but the skin
Since various factors are involved in the performance, the skin condition
It is difficult to improve it sufficiently. [0004] Therefore, in the present invention,
Can improve skin physiology by improving
Demonstrate skin moisturizing effect, beautiful skin effect and skin roughness improvement effect
And it has good compatibility with the skin.
And to obtain an external skin preparation with excellent safety
Was. [0005] Means for Solving the Problems The above problems should be solved.
As a result of various studies, it was found that the extract
And fungal extracts in combination
Good skin moisturizing effect, beautiful skin effect and skin roughness improvement effect
And found that the present invention was completed.
Was. That is, in the present invention,
Extract and calendula, parsley,
Coltsfoot, altea, horse chestnut, carrot
, Tormentilla, hypericum, sage, cucumber,
Fennel, Elderberry, Arnica, Ononis,
Gennoshoko, safflower, siberium, saponosa, sa
Loli, meliloth, loofah, snow-snow, button, us
Veneer oil, Hamamelis, Jujube, Ouren, Shakuya
Ku, Touki, Senkyu, Saishin, Kogananeyanagi, Moth
Numbiroki, Bakuryotake, Zio, Cassia, Kiha
Da, turmeric, clove, mugwort, ginger, mannenta
Ke, adlay, apricot, peach, yuz, kudzu, unshu
One or more plants selected from tangerines and cumin
And a fungal extract are combined and formulated into a skin external preparation. [0007] DESCRIPTION OF THE PREFERRED EMBODIMENTS Plants and fungi used in the present invention
Types will be described. [0008] The beetle used in the present invention is a crude drug.
It is a kind,Onagraceae) Plant willow
(Chamaenerion angustifolium (L.) Scop .;Epilobi
um angustifolium L.), and its leaves are
Contains ninnin, ursolic acid, oleanolic acid, etc.
It is known to have symptomatic effects. The celery used in the present invention (Apium grav
eloens L. var.dulce (Mill.) Pers.)Um
belliferae), Leaves, stems, flowers, fruits
Etc. and whole plants can be used.
It is preferable to use any above-ground parts. The melilot used in the present invention (Melilo
tuis officinalis L.) is a legume (LeguminosaeBelongs to)
Perennial herbs, leaves, stems, flowers, fruits, etc.
Can be used, but use above-ground parts such as leaves and stems
Is preferred. The calendula used in the present invention (Ca
lendula officinalis L.) is asteraceae (CompositaeBelongs to)
First-year to second-year grasses, each part of leaves, stems, flowers, roots, etc.
Whole grass can be used, but flowers are preferred
No. The parsley used in the present invention (Petroselin
um crispum (Mill.) Nym. Ex A.W. Hill.Um
belliferae), A perennial or perennial plant with leaves, stems,
Each part such as flowers and fruits and whole plants can be used,
It is preferred to use leaves and stems. [0013] In the present invention,
Lissa)Melissa officinalis L.)Labiat
aePerennial plants belonging to the following categories: leaves, stems, roots, flowers, etc.
Whole grass can be used, but leaves are preferred
No. In the present invention, coltsfoot (Tuss
ilago farfara L.) is asteraceae (Comp ositaeMany)
For annual plants, use parts such as leaves, stems, flowers, roots, etc. and whole plants.
However, it is preferable to use leaves or flowers. Altea (below) used in the present invention
Mallow) (Althaea officinalis L.) is a mallow family (Malv
aceaePerennial herb belonging to), such as leaves, stems, flowers, and roots
And whole plants can be used, but leaves or roots
Is preferred. [0016] Horse chestnut used in the present invention
(Aesculus turbinata Blume;Aesculus hippocastanu
m L.) is the horse chestnut family (HippocastanaceaeHigh)
For trees, use leaves, branches, bark, flowers, fruits, etc. and all trees
Can use leaves, bark or fruit.
preferable. The carrot used in the present invention (Daucus c
arota L.)UmbelliferaePerennials belonging to
It is possible to use leaves, stems, roots, etc. and whole plants.
However, it is preferable to use a root. The tormentilla used in the present invention (Pote
ntilla tormentilla) Is rose family (RosaceaeMany)
For annual plants, use parts such as leaves, stems, flowers, roots, etc. and whole plants.
However, it is preferable to use roots. Hypericum perforated (used in the present invention)Hype
ricum erectum Thunb .;Hypericum perforatum L.)
Hypericum family (Guttiferae), Leaves,
Can use stems, flowers, roots, etc. and whole plants
However, it is preferable to use whole plants. Sage used in the present invention (Salvia off
icinalis L.) is a Labiatae (LabiataePerennials belonging to
It is possible to use leaves, stems, roots, flowers, etc. and whole plants.
Although it is possible, it is preferable to use leaves. The cucumber used in the present invention (Cucumis
sativus L.), Cucurbitaceae (CucurbitaceaeVine belonging to
1-year-old grass, using all parts of leaves, stems, flowers, fruits, etc.
Although it is possible to use fruits, it is preferable to use fruits. Fennel used in the present invention (Foenic
ulum vulgare Miller)Umbelliferae)
Perennials to which leaves, stems, roots, flowers, fruits, etc.
Whole grass can be used, but fruit is preferred.
New The dried fennel fruit is called Wiki
It is a kind of crude drug called "leopard"
You can also. The elderberry used in the present invention
(Sambucus nigra L.) is the honeysuckle family (Caprifoliac
eae), Leaves, stems, flowers, roots, fruits, berries
Etc. and whole plants can be used.
Preferably, the fruit is used. The arnica used in the present invention (Arnica m
ontana L.) is asteraceae (CompositaePerennials belonging to
It is possible to use leaves, stems, flowers, roots, etc. and whole plants.
One or two parts selected from roots and flower heads
It is preferred to use a position. Ononis used in the present invention (Ononis s
pinosa L.) is a legume (LeguminosaePerennials belonging to
It is possible to use leaves, stems, flowers, roots, etc. and whole plants.
Although it is possible, it is preferable to use roots. The genoshoko (Ge
ranium nepalense Sweet.var.thunbergii (Sieb. Et
Zucc.) Kudo)GeraniaceaeBelongs to)
Perennial plant that uses leaves, stems, flowers, fruits, etc. and whole plants
However, it is preferable to use whole plants. The safflower used in the present invention (Carthama
s tinctorius L.) is asteraceae (CompositaeBelongs to)
Two-year grass, using parts such as leaves, stems, flowers, roots and whole plants
be able to. The assembly used in the present invention (Ophelia
japonica (Schult.) Griseb.)Gentiace
ae), 1-2 years grass, leaves, stems, roots, flowers, etc.
And whole grass can be used, but whole grass can be used
preferable. Also, the dried whole plant of the assembly
It is a crude drug called "Toyaku" and uses such crude drug
You can also. The soap plant used in the present invention (Sapona
ria officinalis L.)Caryophyllacea
ePerennial plants belonging to the following categories: leaves, stems, roots, flowers, etc.
Whole grass can be used, but roots are preferred
No. Dried saponosa roots are called "Saponaria
It is a crude drug called "root", and it is also
it can. The loofah used in the present invention (Luffa cyli
ndrica (L.) Roem)CucurbitaceaeBelongs to)
Annual plant, leaves, stems, flowers, fruits, sap, etc.
Whole grass can be used. In the present invention, the saxifrage (Saxifr
aga stolonifera Meerb.) Is a Saxifragaceae (Saxifrag
aceaePerennials belonging to the following categories: leaves, stems, flowers, fruits, etc.
Position and whole grass can be used, but leaves, stems, etc.
It is preferred to use sites. Buttons used in the present invention (Paeonia su
ffruticosa Andr.) Is a button family (PaeoniaceaeBelongs to)
Perennial plants, leaves, stems, flowers, fruits, roots, etc.
Grass can be used, but root bark is preferred
No. Dried button root bark is called "Pinpi"
It is a crude drug that can be used. [0033] Usvenia oy () used in the present inventionMa
lva sylvestris L.)UmbelliferaeBelongs to)
Two-year grass, leaves, stems, flowers, fruits, roots, etc.
Grass can be used. Hamamelis used in the present invention (Hamame
lis virginiana L.)Hamamelidacea
e), Such as leaves, stems, flowers, fruits, roots, etc.
You can use position and whole grass, but you can use leaves
preferable. The jujube (Ziziphus j
ujuba Mill.) Is the buckthorn family (Rhamnaceae)
The tree to which it belongs, such as leaves, branches, trunks, bark, roots, flowers, fruits, etc.
Although a site can be used, it is preferable to use a fruit.
New In addition, dried fruit of jujube,
It is a crude drug called "saw", and using such a crude drug
You can also. The water used in the present invention (Coptis j
aponica (Thunb.) Makino) is a Ranunculaceae (Ranuncu
laceae), Such as leaves, stems, flowers, fruits, roots, etc.
Each part and whole plant can be used, but root
Is preferred. In addition, the rhizome of the spinach is "
It is a crude drug called such a crude drug
You. The peony used in the present invention (Paeoni
a lactiflora Pall.) Is a button family (Paeoniaceae)
The perennials to which it belongs, such as leaves, stems, flowers, fruits, roots, etc.
Whole grass can be used, but roots are preferred
No. In addition, dried peonies roots in the western
Has been used as a crude drug. In the present invention, the touki (Angelica a
cutiloba (Sieb. Et Zucc.) Kitagawa)Umbe
lliferaePerennials belonging to the following categories: leaves, stems, flowers, fruits, roots, etc.
Can use all parts and whole plants, but use roots
Is preferred. Also, the dried roots of touki are
A kind of crude drug called "Touki"
It can also be used. Sengyu used in the present invention (Cnidiu
m officinale Malino)Umbelliferae)
The perennials to which it belongs, such as leaves, stems, flowers, fruits, roots, etc.
Whole plants can be used, but rhizomes are preferred.
New In addition, dried rhizomes of Senkyu
Is a type of crude drug called Nkyu.
It can also be used. The cysin used in the present invention (Asiarum
sieboldi (miq.) F. Maekawa)
(Aristrochiaceae), Leaves, stems, flowers,
Fruits, roots and other parts and whole plants can be used,
It is preferred to use rhizomes. Also, the rhizome of saishin
The dried one is a kind of crude drug called "saishin"
Yes, such crude drugs can also be used. The willow willow (Scut
ellaria baicalensis Georgi)Labiatae)
Perennial plant belonging to the genus, such as leaves, stems, flowers, fruits, and roots
And whole plants can be used, but it is preferable to use rhizomes.
Good. In addition, the dried roots of the gougon are
Gon is a type of herbal medicine that uses
You can also. The gambier tree used in the present invention (Un
caria gambir (Hunt) Rocb.)Rubiacea
e), Leaves, branches, trunks, bark, roots, flowers, fruits
Etc., but using leaves and shoots
Preferably. Gambir tree leaves and shoots
Dried aqueous extract is a crude drug called "Asenyaku"
Yes, such crude drugs can also be used. In the present invention, Pleurotus mushroom (Po
ria cocos (Fr.) Wolf)Polypo
raceae). Also,
The dried sclerotium is called "Bukryo"
Crude drug, and such a crude drug can also be used. Geo (Rehmannia glutinosa (Gaertn.)
Libosch.) Is a family of Scrophulariaceae (Scrophulariaceae)
The perennials to which it belongs, such as leaves, stems, flowers, fruits, roots, etc.
Whole grass can be used, but roots are preferred
No. In addition, what dried the root of Jio is "Jio"
It is called herbal medicine, and such herbal medicine can be used
You. The cassia used in the present invention (Cinnamomi
cassia Presl.) Is a camphor tree family (LauraceaeBelongs to)
Small trees, leaves, branches, trunks, bark, roots, flowers, fruits, etc.
But bark is preferred.
No. The dried bark of Cassia is called "Kay
It is a crude drug called "hi", and such crude drugs may be used.
it can. In the present invention, yellowfin (Phellodend
ron amurense Pupr.)RutaceaeBelongs to)
Each part of a tree, such as leaves, branches, trunks, bark, roots, flowers, and fruits
Although bark can be used, bark is preferably used.
The dried bark of yellowfin is called “Obaku”
It is a crude drug called
You. The turmeric used in the present invention (Curcuma do
mestica Valet.) Is a ginger family (Zingiberaceae)
The perennials to which it belongs, such as leaves, stems, flowers, fruits, roots, etc.
Whole plants can be used, but rhizomes are preferred.
New The dried turmeric rhizome is called "Uko
Is a type of crude drug called
You can also. The clove used in the present invention (Syzygium
aromaticum (L.) Merril et Perry)
(Myrtaceae), Leaves, branches, trunks, bark,
Each part such as root, flower, fruit, etc. can be used.
Preferably, leaves are used. Also, clove buds
What is dried is a herbal medicine called "Chouji"
Alternatively, such crude drugs can be used. The mugwort (Artemisia
princeps Pamp.), Asteraceae (CompositaeMany)
Annual grass, using leaves, stems, flowers, fruits, roots, etc. and whole plants
However, it is preferable to use leaves. Ma
The dried mugwort leaves are called mugwort.
Is a kind of crude drug that can be used
You. Ginger used in the present invention (Zingiber
officinale Rosc.) Is a ginger family (Zingiberaceae)
Perennial plant belonging to the genus, such as leaves, stems, flowers, fruits, and roots
And whole plants can be used, but it is preferable to use rhizomes.
Good. In addition, dried ginger rhizomes are
It is a kind of crude drug called "kyokyo"
Can also be used. In the present invention, the mushroom mushroom (Gano
derma lucidum (Leyss. Ex Fr.) Karst) is Mannen
Bamboo family (Ganodermataceae).
The dried fruit body of Mannentake is `` Reishi ''
It is a crude drug called
You. The adlay (Coix lac
hryma-jobi L.)GramineaeOne year belonging to
In the grass, use leaves, stems, flowers, seeds, roots, etc. and whole grass
The use of seeds is preferred. Ma
The seeds except the barley seed coat are called “Yokuinin”.
It is a kind of herbal medicine called
it can. The apricot (Prunus arm
eniaca L.), rose family (Rosaceae) Belonging to Takagi,
Use each part of leaves, branches, stems, bark, roots, flowers, fruits, seeds, etc.
However, it is preferable to use seeds. Ma
Apricot seeds are made from a herbal medicine called "Kyounin".
It is a kind, and such crude drugs can also be used. The peach used in the present invention (Prunus persi
ca (L.) Batsch)RosaceaeTakagi belonging to)
And each part of leaves, branches, trunks, bark, roots, flowers, fruits, seeds, etc.
Can be used, but it is preferable to use seeds.
No. Also, peach seeds are a herbal medicine called "tonin"
Such crude drugs can also be used. Yuzu (Citrus junos
 Sieb. Et Tanaka)RutaceaeBelongs to)
Tree, leaf, branch, trunk, bark, root, flower, fruit, seed, pericarp
Etc. can be used, but fruit, peel, seed
It is preferable to use The waste used in the present invention (Pueraria lob
ata (Willd.) Ohwi) is a legume (LeguminosaeBelongs to)
Perennial plant that uses leaves, stems, flowers, fruits, etc. and whole plants
However, it is preferable to use roots. Scum
Is a kind of herbal medicine called "kakon"
Such crude drugs can also be used. Satsuma mandarin orange used in the present invention
(Citrus unshiu Marcovitch) is a Citrus family (Rutacea
e), Leaves, branches, trunks, bark, roots, flowers, fruits
Each part such as fruit, seed, and peel can be used.
It is preferable to use fruits, peels and leaves. Also, Unsh
The dried persimmon peel is called "thinpi"
Is a type of crude drug that can be used
You. The cumin used in the present invention (Cuminum cy
minum L.)UmbelliferaePerennials belonging to
The leaves, stems, roots, flowers, fruits, seeds and other parts and the whole plant
Although it can be used, it is preferable to use seed. Subsequently, plants and fungi used in the present invention
The extraction method of the class extract is described. In the present invention, each of the above plants and fungi is
Although it may be used for extraction as it is, considering the extraction efficiency,
Extraction can be performed after processing such as cutting, drying, and grinding.
preferable. The extraction is performed by immersion in an extraction solvent. Extraction efficiency
Stirring to increase the homogenization in the extraction solvent.
May be used. Extraction temperature starts at about 5 ° C.
Suitably, the temperature is below the boiling point of the medium. The extraction time is
4 hours depending on the type of extraction solvent and extraction temperature
It is appropriate to set it to about 14 days. As the extraction solvent, in addition to water, methanol,
Lower grades such as ethanol, propanol and isopropanol
Alcohol, 1,3-butylene glycol, propylene glycol
Polyvalent of coal, dipropylene glycol, glycerin, etc.
Alcohol, ethyl ether, propyl ether, etc.
Esters, such as ethyl acetate, butyl acetate, etc.
Polarity of ketones such as seton and ethyl methyl ketone
Solvents, and one or more of these can be used.
Select and use the above. Also, saline, phosphate buffer
Liquid, phosphate buffered saline, or the like may be used. [0062] The above-mentioned lysis of pods and the above plants and fungi
The extract by the medium is as it is for external use on the skin according to the present invention.
Can be contained in the preparation, but concentrated and dried
Redissolved in water or polar solvents, or their skin
Decolorization, deodorization and desalting within the range that does not impair the physiological function improving effect
Or column chromatography.
It may be used after performing the fractionation process. In addition,
After purification, freeze-dry and dissolve in solvent before use.
You can also be. In addition, vesicles and
It can also be used by being encapsulated in microcapsules or the like. The above-mentioned plant and fungal extract according to the present invention
The amount of the compound in the external preparation for skin is preferably 0.00
001 to 5% by weight, especially 0.0001 to 1% by weight
It is. If it is within this range, it will be
When combined with plant and fungal extracts from
Effects on stability of plant and fungal extracts in preparations and preparations over time
Can be more effective
it can. The external preparation for skin according to the present invention is a lotion.
Preparations, emulsions, gels, creams, ointments, powders, granules
It can be provided in various dosage forms such as an agent. Also makeup
Skin cosmetics such as water, milky lotion, cream, serum, pack, etc.
Makeup base lotion, makeup base
Base cosmetics such as reams, emulsions, oils, solids, etc.
Mold foundation, eye color, teak color, etc.
Makeup cosmetics, cleansing cream, cleansing
Cleansing foam, cleansing soap, soap
Skin cleanser such as de-shampoo, hair shampoo, f
Cosmetics for hair such as aerinth and hair treatment
Can also be provided. The external preparation for skin according to the present invention includes
Oily components, surfactants, preservatives,
Wetting agents, pigments, UV absorbers, antioxidants, fragrances, fungicides and fungi
Raw materials for pharmaceuticals and cosmetics, such as
It can contain bioactive ingredients such as active agents and whitening agents.
Wear. [0066] EXAMPLES Further, the features of the present invention will be described with reference to Examples.
This will be described in detail. First, the kokai used in the present invention
An example of the preparation of a red extract is shown below. [Sports extract 1]
After crushing, 30 g of a 50% by volume aqueous ethanol solution 3
The sample was immersed in 00 mL and allowed to stand at 25 ° C. for 7 days. Then
The solution is removed by filtration, the filtrate is concentrated under reduced pressure, and further freeze-dried.
Then, the extract was prepared. [Spodum extract 2] Whole grass of willow
Is dried to obtain Koukaishi, which is crushed and then dried.
0g in 1,000 mL of 50% by volume aqueous ethanol solution
It was immersed and allowed to stand at 25 ° C. for 7 days. After that, the insoluble matter is removed by filtration.
The filtrate was concentrated under reduced pressure to dryness, and
And 2. Further, each extraction of the plant used in the present invention
An example of the production of the product is shown below. [Production Example 1 to Production Example 50]
Dry and pulverize 200 g each of the products and fungi, and add 50%
Stirring and extraction at 20 ° C for 3 days in each 1 liter aqueous solution
After discharging, the filtrate was collected by filtration, and Production Example 1 to Production Example 5
0 was obtained. [0071] [Table 1]Next, the extract of Spodoptera litura and Production Examples 1 to
Skin using extracts of plants and fungi shown in Production Example 50
The example of an external preparation is shown. [0073] [Examples 1 to 50] Serum (1) Beeswax 6.00 (% by weight) (2) Cetanol 5.00 (3) Reduced lanolin 8.00 (4) Squalane 27.50 (5) Glyceryl fatty acid ester 4.00 (6) Lipophilic glyceryl monostearate 2.00 (7) Polyoxyethylene (20E.O.)       Sorbitan monolaurate 5.00 (8) Propylene glycol 5.00 (9) Methyl paraoxybenzoate 0.10 (10) Purified water Total amount is 100 (11) Spodum extract 1 0.05 (12) Component of each production example 0.30       (Example: In Example 1, the components of Production Example 1) Production method: The oil phase components (1) to (7) are mixed and dissolved by heating.
° C. On the other hand, mix and dissolve the aqueous phase components (8) to (10)
Heat to 75 ° C. Next, the oil phase component is added to this aqueous phase component.
And then pre-emulsify and homogenize uniformly with a homomixer.
After cooling, (11) and (12) are added and mixed at 40 ° C. Examples 1 to 50 of the present invention and
Prepared instead of purified water without blending the component of (12)
For Comparative Example 1, the effect of improving skin roughness was examined. 25-
A group of 10 healthy 50-year-olds with experimental rough skin
The skin condition before induction is photographed with a microscope and displayed.
The score was determined according to the criteria shown in 2. Experimental rough
For the skin, the inside of the upper arm is ether and acetone (1: 1 volume
Ratio) was induced by treating with a mixture. More
After that, apply the test serum twice a day, morning and night, for 7 days.
1 day and 7 days after application of rough skin
A state score was determined. Table 3 shows the results. [0075] [Table 2] [0076] [Table 3] As shown in Table 3, Examples 1 to 3 of the present invention were used.
Fifth edible extract, plant and fungus according to Example 50
Skin essence formulated with a combination of extracts
As a result, it is clear that
Was. On the other hand, the ratio of
In Comparative Example 1, a tendency to improve rough skin is observed.
However, the improvement effect was lower than that of the example. Further, the skin of the test serum was added to the panelists of each group.
We evaluated the ease of adaptation to the skin. Also during use test
When using the sample, you may feel skin irritation,
Hearing and investigating whether there was an abnormality such as rash
went. Skin familiarity, skin irritation and skin
The presence or absence of abnormalities was scored according to the evaluation criteria shown in Table 4.
It was quantified and the average value of 10 persons was calculated. These results
The results are shown in Table 5. [0079] [Table 4] [0080] [Table 5] In Table 5, Examples 1 to 3 of the present invention are shown.
In the 50 use group, all are well-adapted to the skin
Was obtained. In addition, we used this time for use test
For each sample, skin irritation and abnormal skin
Not allowed. [0082] [Example 51] Cleansing massage cream (1) Purified water Amount based on the total amount as 100 (% by weight) (2) 1,3-butylene glycol 7.00 (3) Sucrose fatty acid ester 3.00 (4) N-stearoyl-L-sodium glutamate 1.00 (5) Carboxyvinyl polymer (1% by weight aqueous solution) 15.00 (6) L-arginine (10% by weight aqueous solution) 1.50 (7) Paraoxybenzoic acid ester 0.10 (8) Squalane 42.00 (9) Behenyl alcohol 1.50 (10) Lipophilic glyceryl monostearate 1.50 (11) Stearic acid 1.00 (12) Glycerin triisostearate 1.00 (13) Beeswax 0.50 (14) Mixed fatty acid triglycerin 0.50 (15) Jojoba oil 0.50 (16) Hardened oil 0.50 (17) Fragrance 0.10 (18) Production Example 7 (Althea) 0.10 (19) Production Example 17 (Ononis) 0.10 (20) Production Example 18 (Gennoshoco) 0.10 (21) Production Example 28 (Ouren) 0.10 (22) Production Example 37 (Cassia) 0.10 (23) Production Example 39 (Turmeric) 0.10 (24) Citrus extract 1 0.01 (25) Citrus extract 2 0.01 (26) Stearyl glycyrrhetinate 0.05 Production method: The oil phase components (8) to (16) are mixed and dissolved by heating.
° C. On the other hand, mix and dissolve the aqueous phase components (1) to (7)
Heat to 70 ° C. The oil phase is gradually added to the aqueous phase component.
And then pre-emulsified, then homogenized uniformly with a homomixer
After cooling, add (17)-(26) at 40 ° C. and mix. [0083] [Example 52] Lotion for wiping (1) Purified water Amount based on the total amount as 100 (% by weight) (2) Ethanol 8.00 (3) Glycerin 4.00 (4) Polyglyceryl monolaurate 0.70 (5) Sodium citrate 0.05 (6) Citric acid 0.01 (7) Sucrose fatty acid ester 0.04 (8) Paraoxybenzoate 0.01 (9) Fragrance 0.05 (10) Production Example 4 (Parsley) 0.10 (11) Production Example 9 (Carrot) 0.10 (12) Production Example 28 (Ouren) 0.10 (13) Production Example 30 (Touki) 0.10 (14) Citrus extract 1 0.01 (15) Citrus extract 2 0.01 (16) dipotassium glycyrrhizinate 0.05 Production method: The components (2) to (16) are added sequentially to (1) and mixed.
Dissolve and homogenize. [0084] [Example 53] Facial cleansing foam (1) myristic acid 18.00 (% by weight) (2) Palmitic acid 3.00 (3) Stearic acid 7.00 (4) Mixed fatty acid triglyceride 0.10 (5) Stearyl glycyrrhetinate 0.05 (6) Self-emulsifying glyceryl monostearate 3.00 (7) Purified water Total amount is 100 (8) Glycerin 17.00 (9) Potassium hydroxide 7.75 (10) Diglycerin 3.00 (11) 1,3-butylene glycol 1.00 (12) N-stearoyl-L-glutamate disodium 1.00 (13) Polyglyceryl monolaurate 0.50 (14) Paraoxybenzoic acid ester 0.10 (15) Production Example 11 (Hypericum perforatum) 0.10 (16) Production Example 4 (Parsley) 0.10 (17) Production Example 7 (Althea) 0.10 (18) Production Example 28 (Ouren) 0.10 (19) Production Example 30 (Touki) 0.10 (20) Citrus extract 1 0.01 (21) Citrus extract 2 0.01 (22) Fragrance 0.10 Production method: The oil phase components (1) to (6) are mixed and dissolved by heating.
° C. On the other hand, mix and dissolve the aqueous phase components (7) to (14)
Heat to 70 ° C. The oil phase is gradually added to the aqueous phase component.
After saponification by addition, the mixture was cooled and subjected to (15) to (22) at 40 ° C.
Add and mix. [0085] [Example 54] Cleansing cream (1) Purified water Amount based on the total amount as 100 (% by weight) (2) Glycerin 15.80 (3) Sucrose fatty acid ester 5.00 (4) Polyoxyethylene glyceryl isostearate 3.00 (5) 1,3-butylene glycol 1.00 (6) Methyl paraoxybenzoate 0.02 (7) Squalane 32.00 (8) Glyceryl tri-2-ethylhexanoate 18.55 (9) Neopentyl glycol dicaprate 9.30 (10) Stearic acid 1.00 (11) Jojoba oil 1.00 (12) Beeswax 1.00 (13) Mixed fatty acid triglyceride 1.00 (14) Fragrance 0.10 (15) Production Example 18 (Gennoshoco) 0.10 (16) Production Example 7 (Althea) 0.10 (17) Production Example 17 (Ononis) 0.10 (18) Production Example 28 (Ouren) 0.10 (19) Production Example 37 (Cassia) 0.10 (20) Production Example 39 (Turmeric) 0.10 (21) Citrus extract 1 0.01 (22) Citrus extract 2 0.01 (23) Stearyl glycyrrhetinate 0.05 Production method: The oil phase components (7) to (13) are mixed and dissolved by heating.
° C. On the other hand, mix and dissolve the aqueous phase components (1) to (6)
Heat to 70 ° C. The oil phase is gradually added to the aqueous phase component.
And then pre-emulsified, then homogenized uniformly with a homomixer
After cooling, add (14) to (23) at 40 ° C. and mix. [0086] [Example 55] Face wash (1) Purified water Amount based on the total amount as 100 (% by weight) (2) Glycerin 17.00 (3) Potassium hydroxide 7.75 (4) Diglycerin 3.00 (5) 1,3-butylene glycol 1.00 (6) Palm oil fatty acid amidopropyl betaine solution               (30% by weight aqueous solution) 1.00 (7) Methyl paraoxybenzoate 0.10 (8) myristic acid 20.00 (9) Palmitic acid 3.00 (10) Stearic acid 5.00 (11) Mixed fatty acid triglyceride 0.10 (12) Self-emulsifying glyceryl monostearate 3.00 (13) Maltitol hydroxyalkyl ether 1.00 (14) Stearyl glycyrrhetinate 0.05 (15) Fragrance 0.30 (16) Production Example 11 (Hypericum perforatum) 0.10 (17) Production Example 4 (Parsley) 0.10 (18) Production Example 7 (Althea) 0.10 (19) Production Example 28 (Ouren) 0.10 (20) Production Example 30 (Touki) 0.10 (21) Citrus extract 1 0.01 (22) Citrus extract 2 0.01 Production method: The oil phase components (8) to (14) are mixed and dissolved by heating.
° C. On the other hand, mix and dissolve the aqueous phase components (1) to (7)
Heat to 70 ° C. The oil phase is gradually added to the aqueous phase component.
After saponification by addition, the mixture was cooled and subjected to (15) to (22) at 40 ° C.
Add and mix. [0087] [Example 56] Lotion (1) Purified water Amount based on the total amount as 100 (% by weight) (2) Ethanol 10.00 (3) Glycerin 1.50 (4) Sodium citrate 0.09 (5) Citric acid 0.02 (6) Methyl parahydroxybenzoate 0.05 (7) Sucrose fatty acid ester 0.04 (8) Fragrance 0.02 (9) Production Example 3 (Tokinsenka) 0.05 (10) Production Example 15 (Sambucus nigra) 0.05 (11) Production Example 27 (jujube) 0.05 (12) Production Example 34 (Gambir tree) 0.05 (13) Production Example 38 (Kihada) 0.05 (14) Citrus extract 1 0.01 (15) Citrus extract 2 0.01 (16) dl-pyrrolidone carboxylate sodium solution 0.01 (17) Amino acid / sugar mixture 0.01 (18) Polyglyceryl monolaurate 0.01 (19) Sodium lactate solution 0.01 (20) Hydrogenated soybean phospholipids 0.01 (21) dipotassium glycyrrhizinate 0.05 Production method: The components (2) to (21) are added sequentially to (1) and mixed.
Dissolve and homogenize. [0088] [Example 57] Emulsion (1) Purified water Amount based on the total amount as 100 (% by weight) (2) Glycerin 3.60 (3) Carboxyvinyl polymer 0.10 (4) N-stearoyl-L-sodium glutamate 0.24 (5) Methyl paraoxybenzoate 0.10 (6) 1,3-butylene glycol 0.01 (7) N-stearoyl-L-glutamate disodium 0.01 (8) Xanthan gum 0.01 (9) Sodium polyacrylate 0.01 (10) L-arginine 0.24 (11) Squalane 3.24 (12) Stearic acid 0.72 (13) Cetanol 0.60 (14) Beeswax 0.48 (15) Lipophilic glyceryl monostearate 0.48 (16) Jojoba oil 0.10 (17) Mixed fatty acid triglyceride 0.10 (18) Behenyl alcohol 0.01 (19) Stearyl glycyrrhetinate 0.05 (20) Ethanol 4.00 (21) Fragrance 0.05 (22) Production Example 7 (Altea) 0.05 (23) Production Example 17 (Ononis) 0.05 (24) Production Example 27 (jujube) 0.05 (25) Production Example 29 (Peony) 0.05 (26) Production Example 35 (Bulk mushroom) 0.05 (27) Production Example 38 (Kihada) 0.05 (28) Citrus extract 1 0.01 (29) Citrus extract 2 0.01 (30) Maltitol solution 0.01 (31) Simi extract 0.01 (32) Hydrogenated soybean phospholipids 0.01 Production method: The oil phase components (11) to (19) are mixed and dissolved by heating.
° C. On the other hand, mix and dissolve the aqueous phase components (1) to (10)
Heat to 70 ° C. The oil phase is gradually added to the aqueous phase component.
And then pre-emulsified, then homogenized uniformly with a homomixer
After cooling, add (20) to (32) at 40 ° C. and mix. [0089] [Example 58] Oil-in-water emulsified cream (1) Purified water Amount based on the total amount as 100 (% by weight) (2) 1,3-butylene glycol 10.00 (3) N-stearoyl-L-sodium glutamate 0.40 (4) Sucrose fatty acid ester 0.40 (5) L-arginine 0.13 (6) Methyl paraoxybenzoate 0.10 (7) Octyldodecyl myristate 7.00 (8) Glycerin 5.00 (9) Squalane 4.00 (10) Lipophilic glyceryl monostearate 3.50 (11) Beeswax 3.00 (12) Stearic acid 1.00 (13) Behenyl alcohol 1.00 (14) Palmitic acid 0.50 (15) Stearyl glycyrrhetinate 0.05 (16) Production Example 6 (Coltsfoot) 0.10 (17) Production Example 23 (Sakinoshita) 0.10 (18) Production Example 31 (Senkyu) 0.10 (19) Production Example 34 (Gambir tree) 0.10 (20) Citrus extract 1 0.01 (21) Citrus extract 2 0.01 Production method: The oil phase components of (7) to (15) are mixed and dissolved by heating.
° C. On the other hand, mix and dissolve the aqueous phase components (1) to (6)
Heat to 70 ° C. The oil phase is gradually added to the aqueous phase component.
And then pre-emulsified, then homogenized uniformly with a homomixer
Then, cool and add (16) to (21) at 40 ° C. and mix. [0090] [Example 59] Pack (1) Purified water Amount based on the total amount as 100 (% by weight) (2) Polyvinyl alcohol 12.50 (3) Ethanol 10.00 (4) Glycerin 5.00 (5) dipotassium glycyrrhizinate 0.05 (6) Tri (caprylic / capric acid) glycerin 0.10 (7) polyethylene glycol (average molecular weight 1540) 3.00 (8) Sorbitan monolaurate 0.30 (9) Fragrance 0.25 (10) Sucrose fatty acid ester 0.05 (11) Methyl paraoxybenzoate 0.02 (12) Hydrogenated soybean phospholipids 0.01 (13) Jojoba oil 0.20 (14) N-coconut fatty acid acyl L-arginine ethyl         ・ DL-pyrrolidone carboxylate 0.10 (15) Mixed fatty acid triglyceride 0.10 (16) Production Example 3 (Tokinsenka) 0.20 (17) Production Example 6 (balloon poppy) 0.20 (18) Production example 27 (jujube) 0.20 (19) Production Example 29 (Peony) 0.20 (20) Citrus extract 1 0.01 (21) Citrus extract 2 0.01 Production method: The components (2) to (21) are added sequentially to (1) and mixed.
Dissolve and homogenize. Note that each embodiment of the present invention was performed at 25 ° C.
Coloration, odor, and solidification of components when stored for 6 months
No change in state such as collection, precipitation or deposition, or phase separation
It did not fit. [0092] As described in detail above, according to the present invention, a high
Has a skin moisturizing effect, a beautiful skin effect and a skin roughness improving effect,
It has good compatibility with the skin, and has excellent formulation stability and safety.
Was obtained.

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Claims (1)

[Claim 1] Claims 1
Parsley, red mint, coltsfoot, altea, horse chestnut, carrot, tormentilla, hypericum, sage, cucumber, fennel, elderberry, arnica, ononis, genoshoko, safflower,
Assemblies, savonsou, celery, melilot, loofah,
Yukinoshita, Button, Usvenia oyster, Hamamelis, Jujube, Ouren, Peony, Touki, Senkyu, Saishin, Kogananeyanagi, Gambiroki, Bakuryotake, Zio, Cassia, Kihada, Turmeric, Clove, Artemisia, Ginger, Manmotake, Zebra An external preparation for skin comprising one or more plant and fungal extracts selected from, kudzu, unshiu mandarin and cumin.