JP2003313142A - Nutrition composition - Google Patents

Abstract

(57) [Summary] [Problem] A nutritionally excellent liquid or powdered nutrient composition used for nutritional supplementation to a patient who cannot take a normal diet, especially to the elderly or a care recipient. Offering things. SOLUTION: The nutritional component contains milk protein, soy protein, lipid, dietary fiber, oligosaccharide, catechins or polyphenols, vitamins, minerals and trace elements, and the weight ratio of milk protein / soy protein is 0 / 1 to 4/1, and the composition of fatty acids in lipids is 3 to 20% by weight of ω3 fatty acids.
And the ω6 fatty acid is 10 to 40% by weight, the weight ratio of ω3 fatty acid / ω6 fatty acid is 1/6 or more, and the content of water-soluble dietary fiber and / or oligosaccharide is 2
The nutritional composition is prepared such that the content of catechins or polyphenols is 0.1 to 2% by weight based on the total solid content.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a liquid or powder nutritional composition used for nutritional supplementation to a patient who cannot take a normal diet, particularly to an elderly person or a person requiring nursing care.

[0002] The present invention has an excellent nutritional effect and also an effect of improving the intestinal tract function of an elderly person or a care recipient who has an inferior digestive tract function, and a long-term infusion or enteral nutritional supplement for the elderly person. It prevents myocardial abnormalities and bone atrophy associated with administration, and has an effect of improving defecation abnormalities and stool odors by optimizing intestinal flora.

[0003]

2. Description of the Related Art There are various factors for the elderly and care recipients to lead healthy lives, but nutrition is a particularly important issue. How to maintain this nutritional management is considered to be the key to health management for the elderly and care recipients. Nutritional support is provided through a normal diet for healthy people. Therefore, it is necessary to ingest various foods in good balance.

[0004] The nutritional views that are important in considering health and illness in the elderly and care recipients are not very clear. However, the required amounts of macronutrients such as the three major nutrients, minerals, and vitamins have been clearly specified, and nutritional compositions and the like corresponding to these have been supplied. On the other hand, along with the recent progress in nutritional science, many physiological actions are being clarified in food ingredients other than these macronutrients.
For example, the effects of water-soluble dietary fiber (hereinafter abbreviated as dietary fiber in the present invention) and oligosaccharides are shown to improve bowel movements, prevent hyperlipidemia, optimize intestinal flora, supply energy to intestinal mucosa, etc. Is being done. Now, dietary fiber and oligosaccharide have come to be listed as one of the nutritional components to be ingested.

Although selenium is one of the mineral components, it has not been positively blended in conventional nutritional compositions such as enteral nutrients, on the other hand, it is irreversible and fatal such as myocardial abnormality. It has become clear that deficiency symptoms occur. Among vitamin Ks, which are one of the fat-soluble vitamins, vitamin K ₁ has been conventionally blended as a component of nutritional composition, but it is prescribed for the elderly and care recipients to prevent thromboembolism. It has been shown to diminish the effects of warfarin. On the other hand, even if it is the same vitamin K, vitamin K
_{In 2} , it is clear that this weakening effect is weak.

Further, catechins derived from tea such as green tea, oolong tea and black tea and polyphenols derived from grape seeds are
It has the effect of protecting against damage such as tissue damage due to radicals in the digestive tract, and also has the effect of preventing abnormal fermentation in the intestinal tract, improving the intestinal flora and reducing stool odor. Are known.

Conventionally, various nutritional compositions have been used in the surgical and medical fields. In these nutritional compositions,
It contains many essential nutrients such as lipids and proteins.
In particular, lipids are being studied, and medium-chain fatty acid triglycerides, which are extremely rapidly digested and absorbed, soybean oil, corn oil, and safflower oil having high linoleic acid content are mainly used. . The essential fatty acid, which is one of the indicators of the nutritional components of lipids, is linoleic acid. Like the linoleic acid, α-linolenic acid, which is an essential fatty acid that is not biosynthesized in the human body, is contained in the oils and fats in a very small amount. As human deficiency of α-linolenic acid, neurological symptoms such as paresthesia and dermatitis have been reported, and in recent years, physiological functions of ω3 series (α-linolenic acid) fatty acids and their metabolites have been elucidated, and ω3 series. The importance of the role of α-linolenic acid, which is the starting material for metabolism, has been reconfirmed. That is, eicosapentaenoic acid and docosahexaenoic acid, which are α-linolenic acid and its metabolites, have serum lipid improvement and antithrombotic action, anti-inflammatory action, antihypertensive action, immunosuppressive action, and tumor metastasis inhibiting action, There are expectations for prevention and improvement of various diseases.

[0008] In recent years, it has become popular to consider the diets of the elderly and care recipients by integrating these nutritional knowledge. However, there are few tube and enteral nutritional supplements with such consideration.

As described above, the conventional nutritional composition has a low α-linolenic acid content in terms of lipids, and is designed with emphasis on linoleic acid alone. It is hard to admit. In addition, with the progress of tube feeding methods, it is possible to use nutritional compositions from the early stage of surgery, and along with the spread of home tube feeding methods, the period of use of tube feeding agents has been prolonged. A nutritional composition having a well-balanced fatty acid / ω6 fatty acid ratio is further desired.

On the other hand, as the protein, milk protein, soybean protein, egg protein and the like are used in consideration of amino acid composition, protein value, absorbability and the like. Alternatively, degradation products thereof or amino acids or combinations thereof have also been used. It has been reported that soybean protein or its degradation product or a nitrogen source derived from a combination of soybean protein and milk protein has a serum lipid-improving action, a hypotensive action and the like. It is well known that serum lipids are improved by polyunsaturated fatty acids such as linoleic acid, α-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid. There is a need for a nutritional composition having biological activity.

Further, the most frequent side effect in oral or tube feeding is diarrhea. In particular, it occurs around 20% after surgery. For this reason, diarrhea has become a major problem that unexpectedly bothers patients and health care workers. It is no exaggeration to say that the development goals of oral and tube feeding compositions have always been to prevent the occurrence of diarrhea. If diarrhea occurs during oral or tube feeding, the infusion rate of the nutritional composition is controlled, and in the worst case, the administration must be discontinued. In this case, non-physiological parenteral nutrition must be performed because the patient cannot be provided with the necessary and sufficient amount of heat. Therefore, the development of a nutritional composition that suppresses the occurrence of diarrhea is an issue that must be solved immediately in consideration of nutritional supplementation for the elderly and care recipients.

The inventor of the present invention has conducted extensive studies on the above expected nutritional composition. In particular, with regard to the main nutritional components, a nutritional composition which is nutritionally excellent and has an effect of preventing the occurrence of diarrhea has already been developed and disclosed which contains ω3 fatty acid and soybean protein as a protein. (Japanese Patent Laid-Open No. 4-152861).

[0013]

DISCLOSURE OF THE INVENTION In addition to the effects of main nutritional components, the present invention further improves the bowel movements, prevents hyperlipidemia, and optimizes the intestinal flora by adding components other than macronutrients.
An object is to provide a nutritional composition having a physiological effect such as energy supply to the intestinal mucosa. Further, the present invention prevents the fatal deficiency symptoms that rarely occur by the administration of oral and tube feeding agents, and reduces the effect of warfarin used for the purpose of preventing thromboembolism in the elderly and care recipients. The challenge is to provide nutritional supplements with low levels. Another object of the present invention is to provide a nutritional composition having an action of protecting against damage such as tissue damage due to radicals in the digestive tract and having an effect of reducing stool odor.

[0014]

The present invention has the following configuration. 1. As a nutritional component, milk protein, soy protein, lipid, dietary fiber, oligosaccharide, catechins or polyphenols,
Contains vitamins, minerals, and trace elements, the milk protein / soy protein weight ratio is 0/1 to 4/1, and the constituent fatty acid composition in the lipid is ω3 fatty acid 3 to 20 wt% and ω6 fatty acid 10
-40% by weight, the ratio of ω3 fatty acid / ω6 fatty acid is 1/6 or more, and the content of water-soluble dietary fiber and / or oligosaccharide is 2-6% by weight based on the total solid content. , Catechins or polyphenols content per total solids
A nutritional composition which is 0.1-2% by weight. 2. 3. The nutritional composition according to 1 above, wherein the ω3 fatty acid is at least one fatty acid selected from the group consisting of α-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid, and the ω6 fatty acid is linoleic acid. 3. The nutritional composition according to 1 or 2 above, which contains selenium as a trace element, and the selenium content is 4 to 16 μg per 100 kcal of the nutritional composition. 4. 4. The nutritional composition according to any one of 1 to 3 above, wherein selenium is selenite, a selenoamino acid, or a selenium-containing microbial cell. 5. As a vitamin, vitamin K ₂ is a nutritional composition 100 kcal
4. The nutritional composition as described in any one of 1 to 4 above, which contains 4 to 16 μg. 6. The nutrition composition according to any one of 1 to 5 above, wherein the catechins or polyphenols are tea-derived catechins or grape seed-derived polyphenols.

[0015]

BEST MODE FOR CARRYING OUT THE INVENTION Among the components constituting the nutritional composition according to the present invention, it is necessary to combine specific lipids and proteins in a fixed ratio as main nutritional components. Also, among the nutritional components other than the main components, dietary fiber, oligosaccharides, selenium, which is one of the trace element mineral components, vitamin K ₂ ,
Add catechins and polyphenols.

That is, a fatty acid composition in which the fatty acid composition of lipid is 3 to 20% by weight of ω3 fatty acid and 10 to 40% by weight of ω6 fatty acid, and the weight ratio of ω3 fatty acid / ω6 fatty acid is 1/6 or more. Use lipids from. Also, as a protein,
The protein is composed of milk protein and soy protein, and the ratio of both is 0/1 to 4/1 milk protein / soy protein.

As the above-mentioned lipid, a lipid containing an ω3 fatty acid is mixed. Particularly preferred ω3 fatty acids are α-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid, and the total of ω3 fatty acids is 3 to 20% by weight in the fatty acid composition.
What contains is used. Also, a lipid containing ω6 fatty acid is added. A particularly preferred ω6 fatty acid is linoleic acid. This ω6 fatty acid is 10-4 in the fatty acid composition of lipids.
The one containing 0% by weight is used. ω3 fatty acids and ω
Examples of oils containing both 6-fatty acids include perilla oil, perilla oil, linseed oil, tung oil, fish oil, safflower oil, corn oil, soybean oil, rapeseed oil and the like. By mixing two or more of these oils,
A lipid having the ω3 / ω6 ratio necessary for the constitution of the present invention can be obtained.

Milk protein and soybean protein are used as the protein (nitrogen source), and milk protein / soybean protein is used from the standpoint of preventing diarrhea, improving faeces, pharmacological activity, cardiovascular disease, and preventive effect against chronic diseases. The protein ratio is 0/1 to 4/1.

Dietary fiber includes water-soluble pectin derived from fruits and vegetables, glucomannan derived from konjac and yam, galactomannan derived from oats and beans, alginic acid derived from seaweeds such as agar, kelp and seaweed, carrageenan derived from red algae, etc. One or more components selected from are blended. The oligosaccharide is blended with one or more components selected from fructooligosaccharide, soybean oligosaccharide, galactooligosaccharide, xylooligosaccharide and the like. It is preferable that the dietary fiber and the oligosaccharide are mixed so that the total amount thereof is 2 to 6% by weight based on the total solid content, and the dietary fiber / oligosaccharide ratio is adjusted to 4/1 to 1/0. If the amount of oligosaccharide is increased from this value, the tendency of diarrhea to occur becomes unfavorable.

The nutritional composition of the present invention is characterized by controlling the content of selenium, which is a trace element. Selenium may be in an organic or inorganic form, and is a selenium-containing microorganism derived from a microorganism having selenium-accumulating ability obtained by culturing in a medium containing selenium salt, selenoamino acid, and a high concentration of selenium compound. Bacteria can be used. Further, the selenium compound and microbial cells are blended so that the selenium content in the nutritional composition of the present invention is 4 to 16 μg per 100 kcal of the nutritional composition. If the selenium content exceeds 16 μg, there is concern about safety. When the amount is less than 4 μg, deficiency such as myocardial abnormality which is the object of the present invention cannot be prevented.

Further, the nutritional composition of the present invention is characterized in that the vitamin K ₂ content is adjusted as vitamin K. Vitamin K ₂ is derived from natto bacteria such as menaquinone-7
Is preferably blended, and the nutritional composition is blended so as to contain 4 to 16 μg per 100 kcal. If it exceeds 16 μg, side effects such as the above-mentioned effects of warfarin are diminished, which is not preferable. If less than 4 μg,
It is not preferable because the preventive effect on thromboembolism is diminished.

Furthermore, the present invention has a nutritional composition containing catechins or polyphenols, which has an action of protecting against damages such as tissue damage caused by radicals in the digestive tract and has an effect of reducing stool odor. It is characterized by being As the catechins, it is preferable to use catechins derived from tea and containing epigallocatechin gallate in an amount of 10 to 70% by weight. Examples of polyphenols include tannin which is a polymer of catechin and proanthocyanidins derived from grape seeds. The origin and morphology of the catechins or polyphenols are not particularly limited, but those derived from tea such as green tea, oolong tea, black tea, or those derived from grape seeds are preferred. Catechins or polyphenols are blended so as to be 0.1 to 2% by weight based on the total solid content of the nutritional composition. When the content of catechins or polyphenols is less than 0.1%, the desired effect of improving the stool odor is not observed, and when the content exceeds 2%, the flavor of the nutritional composition is deteriorated or in extreme cases. It is not preferable because it will have an astringent taste.

The nutritional composition of the present invention depends on age, symptoms, etc.
It varies from 800 kcal to 2500 k per day for each adult human
It is preferable to administer cal orally or by tube / enteral administration.
Good In addition, soybean protein which is the active ingredient of the present invention, ω3 series
Fats and oils containing fatty acids, water-soluble dietary fiber, oligosaccharides,
Len, vitamin K₂, Other than catechins or polyphenols
As a nutritional ingredient of protein, protein hydrolyzate, amino
Contains acids, lipids, sugars, vitamins, minerals, etc.
Can be prepared. At this time, the protein or
The hydrolyzate of these is preferably excellent in digestion and absorption.
Therefore, those having a high nutritional value are preferable. Eg egg protein, small
Using wheat protein, or their degradation products and amino acid mixtures
May be. As a lipid, it is rapidly digested and absorbed
A chain fatty acid triglyceride or the like may be used. With sugar
For example, starch, dextrin, sucrose, glucose
Course, galactose, maltose, etc. are mentioned.
As minerals, Na, K, Ca, Mg, P, Cl, F
an organic or inorganic salt such as e, Zn, Cu, Mn or I,
As vitamins, fat-soluble vitamins A, D, E, etc.
Sex vitamins and vitamin B₁ , B ₂ , B₆, B₁₂, C,
Water-soluble such as pantothenic acid, niacin, biotin, folic acid
Use sex vitamins.

Although the form of the nutritional composition of the present invention is not particularly limited, for example, a powdery product obtained by mixing each active ingredient and each nutritional ingredient into a powder, and a liquid composition obtained by dissolving in water. A powder obtained by drying a liquid is preferable. The nutritional composition thus obtained is used for nutritional supplementation to a patient who cannot ingest normal food, an elderly person or a person requiring nursing care. The form of administration may be oral, tube, or enteral depending on the situation. In preparing the liquid nutritional composition, an emulsifier such as phospholipid, glycerin fatty acid ester, sucrose fatty acid ester may be used, if necessary.

[0025]

The present invention will be described in more detail with reference to the following examples, but these are merely examples and the present invention is not limited thereto. (Production Example 1) Production of liquid preparation A liquid sterile nutrient was prepared according to a conventional method with the formulation shown in Table 1. The ratio of milk protein to soybean protein in this nutritional composition was 2/1. The fatty acid composition is 36.5% caprylic acid.
, Α-linolenic acid 9.2%, linoleic acid 25.9%,
The ratio of ω3 fatty acid / ω6 fatty acid was 1 / 2.82. A guar gum degradation product was used as the water-soluble dietary fiber and galactosyl lactose was used as the oligosaccharide, and the blending amounts were 3.2% by weight and 0.8% by weight, respectively, based on the solid content. Tea-derived catechins were used as catechins. The compounding amount was 1% by weight based on the solid content. As selenium, selenium-containing yeast cells were used, and selenium was mixed at 10 μg. Minerals other than selenium are Na, K, Ca, Mg, P, C.
1, a mixture of organic or inorganic salts such as Fe, vitamins other than vitamin K ₂ are vitamins A, D, E, vitamins B ₁ , B
A mixture of ₂ , B ₆ , B ₁₂ , C, niacin, pantothenic acid, and folic acid was added to each of them so as to meet the national nutritional requirements.

[0026]

[Table 1]

(Production Example 2) Production Example 2 was repeated except that 0.8 g of soybean oil and 78.25 mg of perilla oil (78% fatty acid / ω6 fatty acid ratio: 1/5) were used per 100 ml of the liquid preparation. Manufactured. The composition of minerals and vitamins including selenium and vitamin K ₂ was the same as in Production Example 1.

(Production Example 3) Production of liquid preparation: 1.67 g of milk protein, 3.4 g of soy protein (ratio of milk protein / soy protein: 1/2), 0 g of soybean oil and 1.21 of perilla oil per 100 ml.
It was produced in the same manner as in Production Example 1 except that it was adjusted to g (ratio of ω3 fatty acid / ω6 fatty acid: 3/1). The composition of minerals and vitamins including selenium and vitamin K ₂ was the same as in Production Example 1.

(Production Example 4) Production of powdered preparation With the formulation shown in Table 2, a powdered preparation of the present invention was prepared by a conventional method. The fatty acid composition of this lipid is 3.2-α-linolenic acid.
%, Linoleic acid 25.7%, eicosapentaenoic acid 7.7%,
Docosahexaenoic acid 4.5%, ω3 fatty acid / ω6
The system fatty acid was 1 / 1.67. The ratio of milk protein to soybean protein was 1/3. The composition of minerals and vitamins including selenium and vitamin K ₂ was the same as in Production Example 1.

[0030]

[Table 2]

[0031]

The test examples conducted for confirming the effects of the present invention are shown below. Confirmation test of nutritional state improving effect using aged rats Three kinds of test nutritional supplements A, B, and C in which the components of the nutritional composition for animal tests having the constitution of the present invention were adjusted based on Table 3
Was prepared and used for the test. In addition, a commercially available nutritional supplement (Ensure (registered trademark)) D as a control nutritional agent, a milk protein / soy protein ratio of 6/1, and an ω3 fatty acid / ω6 fatty acid ratio of 10/1 are water-soluble. Dietary fiber and oligosaccharides 8% by weight, selenium 25 μg / 100 kcal, vitamin K ₂ 50 μg / 100
A nutritional composition E containing kcal and 3% by weight of catechin was used.
The blending amount of each nutrient component of each nutrient A, B, C, E used in the experiment, the ratio of milk protein / soy protein which is the component according to the present invention of each nutrient A to D, and ω3 fatty acid / Ratio of ω6 fatty acids, other active ingredients water-soluble dietary fiber,
Table 3 shows characteristic values of oligosaccharides, selenium, vitamin K ₂ and catechins.

[0032]

[Table 3]

The SD rats were a group of 10-year-old male rats aged 1 year and 8 months, which were preliminarily bred for about 1 year under the restricted feeding in which 70% (60 kcal / animal) of the required energy amount per day was administered according to the conventional method. A total of 50 animals were used (weight: 358 to 425 g). The breeding environment is temperature 23 ± 2 ℃, humidity 50 ± 10%, lighting 7 am-7pm,
Ventilation was 15 times / hour, and filtered water was given to drinking water. Grouping was performed based on the body weight before the start of the experiment (1 year and 8 months old), so that each group was almost even.
The experiment was carried out in 5 groups of 10 animals each. From the beginning of the experiment, each nutrient of Table 3 containing the preparation of the present invention was administered to rats while being restricted to ingest 60 kcal per day, and kept for 2 months. In addition, body weight was measured every Monday morning during the experimental period. A fecal collection period was provided for 3 days from the 7th week during the rearing. Further, on the last day of the experiment, whole blood was collected and sacrificed, and serum was collected from the obtained blood.

The measurement results of body weight change are shown in FIG. For the purpose of determining nutritional status, albumin in serum,
The total protein concentration, and further the serum transferrin concentration, which is a more sensitive nutritional index, were measured, and the results are shown in FIGS. 2-1, 2-2, and 2-3. All results were expressed as mean value ± standard deviation, and comparison between groups of each index was performed by the multiple comparison method of analysis of variance (Fisher test).

With respect to the collected feces, 20 testers were selected, and the smell was sensory evaluated. The test results are shown in Table 4. The fecal odor of the feces in each group was evaluated, and the total number of testers who corresponded to each evaluation item is shown. The Wilcoxon test method was used to compare the groups.

[0036]

[Table 4]

As a result, the nutritional supplements A, B and C of the present invention were found to have a better weight-maintaining effect than the nutritional supplements D and E. Each nutritional supplement was administered to 4 week old rats (10 rats per group).
When the increase in body weight after weekly administration was measured, no significant difference was observed. In addition, the results of nutritional evaluation using serum protein of the aged rat as an index also confirmed that it has an effect of maintaining the nutritional condition of the aged animal in a good condition. Regarding the odor of feces, the nutritional supplements A, B and C of the present invention were confirmed to have an improving effect as compared with the nutrient D. From the above results, it has been clarified that the nutritional composition of the present invention is a nutritionally excellent composition especially for elderly people who are apt to deteriorate their nutritional status and is also excellent in improving stool odor.

[Brief description of drawings]

FIG. 1 shows the results of body weight measurement when the nutritional composition of Table 3 was administered to aged rats.

FIG. 2 shows the measurement results of nutritional indexes when the nutritional composition shown in Table 3 was administered to aged rats. 1. The albumin concentration in serum is shown. 2. The total protein concentration in serum is shown. 3. The transferrin concentration in serum is shown.

Front page continuation (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61P 3/06 A61P 3/06 7/02 7/02 9/00 9/00 9/12 9/12 19/00 19 / 00 29/00 29/00 35/00 35/00 37/06 37/06 F term (reference) 4B018 MD05 MD08 MD14 MD20 MD23 MD31 MD47 ME02 4C084 AA24 MA02 ZA361 ZA362 ZA421 ZA422 ZA541 ZA542 ZA661 ZA662 ZA961 ZA962 ZB081 ZB082 ZB111 ZB112 ZB261 ZB262 ZC211 ZC212 ZC331 ZC332 4C206 AA02 DB09 MA03 MA06 ZA36 ZA42 ZA54 ZA66 ZA96 ZB08 ZB11 ZB26

Claims (6)

[Claims] 1. As a nutritional component, milk protein, soybean protein, lipid, dietary fiber, oligosaccharides, catechins or polyphenols, vitamins, minerals, trace elements,
The milk protein / soybean protein weight ratio is 0/1 to 4/1, and the constituent fatty acid composition in the lipid is ω3 fatty acid 3 to 20% by weight and ω
6-based fatty acid 10 to 40% by weight, and ω3 fatty acid / ω6
The weight ratio of the system fatty acid is 1/6 or more, the content of water-soluble dietary fiber and / or oligosaccharide is 2 to 6% by weight based on the total solid content, and the content of catechins or polyphenols is the total solid content. A nutritional composition which is 0.1 to 2% by weight. 2. The ω3 fatty acid is at least one fatty acid selected from the group consisting of α-linolenic acid, eicosapentaenoic acid, and docosahexaenoic acid, and the ω6 fatty acid is linoleic acid. Nutrition composition. 3. The nutritional composition according to claim 1, which contains selenium as a trace element, and the selenium content is 4 to 16 μg per 100 kcal of the nutritional composition. 4. The nutritional composition according to claim 1, wherein the selenium is selenite, a selenoamino acid or a selenium-containing microbial cell. 5. The nutritional composition according to claim 1, which contains 4 to 16 μg of vitamin K ₂ per 100 kcal of the nutritional composition as a vitamin. 6. The nutritional composition according to claim 1, wherein the catechins or polyphenols are tea-derived catechins or grape seed-derived polyphenols.