JP2003135080A - 新規遺伝子及びそれにコードされる蛋白質 - Google Patents

Abstract

(57)【要約】 （修正有） 【課題】ヒト成人全脳、ヒト成人海馬及びヒト胎児全脳
由来のｃＤＮＡライブラリーから、蛋白質をコードして
いる領域を含む新規なＤＮＡを直接クローニングし、そ
れらの塩基配列を決定し、更にそれらの機能を同定する
こと。 【解決手段】以下の（ａ）又は（ｂ）のポリペプチドを
コードする塩基配列を含むＤＮＡ：（ａ）特定の配列
（但し、一部の配列は除く）のいずれか一つで示される
アミノ酸配列と同一又は実質的に同一のアミノ酸配列か
ら成るポリペプチド、（ｂ）特定の配列（但し、一部の
特定の配列は除く）のいずれか一つで示されるアミノ酸
配列において、一部のアミノ酸が欠失、置換又は付加さ
れたアミノ酸配列から成り、（ａ）のポリペプチドの機
能と実質的に同質の生物学的活性を有するポリペプチ
ド、上記ＤＮＡにコードされる組換えポリペプチド、及
び該ポリペプチドを含む蛋白質。

Description

【発明の詳細な説明】

【０００１】

【発明の属する技術分野】本発明は、ＤＮＡ及び該ＤＮ
Ａを含む遺伝子、並びに該ＤＮＡにコードされる組換え
ポリペプチド及び該ポリペプチドを含む新規組換え蛋白
質に関する。

【０００２】

【従来の技術】ヒトゲノム計画における大規模シークエ
ンシングによって、ヒトゲノムの塩基配列に関する情報
が日々産出されている。ヒトゲノム計画の最終目的は単
にゲノム全塩基配列を決定することではなく、その構造
情報、即ち、ＤＮＡの塩基配列情報からヒトのさまざま
な生命現象を読み解くことにあろう。ヒトゲノム配列中
で蛋白質をコードしている領域はその極一部であり、現
在は、ニュートラルネットワークや隠れマルコフモデル
と呼ばれる情報科学の手法を用いて、そのコード領域の
予測が行われている。しかしながら、それらの予測精度
はまだ充分なものではない。

【０００３】今回、本発明者は新規な遺伝子を見出すべ
く、ヒト成人全脳、ヒト成人海馬及びヒト胎児全脳由来
のｃＤＮＡライブラリーから、蛋白質をコードしている
領域を含む新規なＤＮＡを直接クローニングすることに
成功し、それらの塩基配列を決定して本発明を完成させ
た。

【０００４】

【課題を解決するための手段】即ち、本発明は第一の態
様として、以下の（ａ）又は（ｂ）のポリペプチドをコ
ードする塩基配列を含むＤＮＡに係る： （ａ）配列番号：１乃至４４（但し、配列番号７、１１
及び２５は除く）のいずれか一つで示されるアミノ酸配
列と同一又は実質的に同一のアミノ酸配列から成るポリ
ペプチド、（ｂ）配列番号：１乃至４４（但し、配列番
号７、１１及び２５は除く）のいずれか一つで示される
アミノ酸配列において、一部のアミノ酸が欠失、置換又
は付加されたアミノ酸配列から成り、（ａ）のポリペプ
チドの機能と実質的に同質の生物学的活性を有するポリ
ペプチド。本発明の第二の態様として、以下の（ａ）又
は（ｂ）のＤＮＡに係る： （ａ）配列番号：１乃至４４（但し、配列番号７、１１
及び２５は除く）のいずれか一つで示される塩基配列に
おいて、夫々の配列で示されるアミノ酸配列をコードす
る塩基配列を含むＤＮＡ、(ｂ）（ａ）のＤＮＡとスト
リンジェントな条件下でハイブリダイズし、（ａ）のポ
リペプチドの機能と実質的に同質の生物学的活性を有す
る蛋白質をコードするＤＮＡ。以上の本発明の第一及び
第二の態様であるＤＮＡをまとめて、以下、「本発明Ｄ
ＮＡ」ともいう。又、本発明はこれらＤＮＡを含む遺伝
子にも係る。更に、本発明は上記ＤＮＡ又は遺伝子にコ
ードされる組換えポリペプチド（以下、「本発明ポリペ
プチド」ともいう。）、及び該ポリペプチドを含む組換
え蛋白質に係る。

【０００５】本発明ＤＮＡを有するクローンの名称、本
発明ポリペプチド又は蛋白質の長さ、その機能について
は、表１乃至表３に示されている。

【０００６】本発明ＤＮＡは、市販されている（クロン
テック社）ヒト成人全脳、ヒト成人海馬及びヒト胎児全
脳のｍＲＮＡを出発材料として、本発明者が調製したｃ
ＤＮＡライブラリーから、ｃＤＮＡ断片として単離した
後に、塩基配列を決定し同定したものである。即ち、具
体的には、小原他の方法（DNA Research Vol.4,53−59
（1997））に従って調製したヒト成人全脳、ヒト成人海
馬及びヒト胎児全脳由来のｃＤＮＡライブラリーからク
ローンをランダムに単離する。次に、ハイブリダイゼー
ションにより、重複クローン（繰り返し出てくるクロー
ン）を除き、その後インビトロでの転写翻訳を行い５０
ｋＤａ以上の産物が認められるクローンについてその両
末端の塩基配列を決定する。更に、こうして得られた末
端塩基配列をクエリーとして既知遺伝子のデータベース
に相同性検索を行い、その結果、新規であることが判明
したクローンについて全塩基配列を決定する。このよう
にして既知の遺伝子に依存した従来のクローニング方法
では得られなかった未知の遺伝子も、システマチックに
クローニングを行なうことができる。又、短い断片や得
られた配列に人工的な間違いが起こらないように十分な
注意を払いながら、ＲＡＣＥ等のＰＣＲ法を使用するこ
とによっても、本発明ＤＮＡを含むヒト由来遺伝子の全
領域を調製することも可能である。

【０００７】更に、本発明は、本発明ＤＮＡ又は本発明
ＤＮＡを含む遺伝子を含有する組換えベクター、該組換
えベクターを保持する形質転換体、該形質転換体を培養
し、本発明ポリペプチド若しくは該ポリペプチドを含む
組換え蛋白質を生成、蓄積せしめ、これを採取すること
を特徴とする、本発明ポリペプチド若しくは該ポリペプ
チドを含む組換え蛋白質、又はその塩の製造方法、及
び、こうして得られる本発明ポリペプチド若しくは該ポ
リペプチドを含む組換え蛋白質又はその塩を提供する。

【０００８】又、本発明は、本発明ＤＮＡ又は遺伝子を
含有してなる医薬、本発明ポリペプチド若しくはその部
分ポリペプチド又は該ポリペプチドを含む組換え蛋白質
をコードする塩基配列を含むポリヌクレオチド（ＤＮ
Ａ）、それら塩基配列に実質的に相補的な塩基配列を有
するアンチセンスヌクレオチド、該ポリヌクレオチド又
はアンチセンスヌクレオチドを含有してなる医薬、本発
明ポリペプチド若しくはその部分ポリペプチド、及び、
該ポリペプチド又はそれらを含む組換え蛋白質を含有し
てなる医薬に係る。更に、本発明は、本発明ポリペプチ
ド若しくはその部分ポリペプチド又は該ポリペプチドを
含む組換え蛋白質又はそれらの塩に対する抗体、及び、
本発明ポリペプチド、その部分ポリペプチド若しくは該
ポリペプチドを含む組換え蛋白質又はそれらの塩、又は
それらに対する抗体を用いることを特徴とする、それら
物質と特異的に相互作用する物質のスクリーニング方
法、スクリーニング用キット、並びに、該スクリーニン
グ方法によって同定される物質（化合物）自体等にも係
る。

【０００９】

【発明の実施の形態】本発明ＤＮＡとしては、前述した
本発明ポリペプチドをコードする塩基配列から成るもの
であればいかなるものであってもよい。また、ヒトの
脳、又は、それ以外の組織、例えば、心臓、肺、肝臓、
脾臓、腎臓、精巣、等の細胞・組織に由来するｃＤＮＡ
ライブラリー等から同定・単離されたｃＤＮＡ、又は、
合成ＤＮＡのいずれでもよい。ライブラリー作成に使用
するベクターは、バクテリオファージ、プラスミド、コ
スミド、ファージミドなどいずれであってもよい。ま
た、前記した細胞・組織よりtotalＲＮＡ画分またはｍ
ＲＮＡ画分を調製したものを用いて、直接ReverseTrans
cription coupled Polymerase Chain Reaction（以下、
「ＲＴ-ＰＣＲ法」と略称する）によって増幅すること
もできる。

【００１０】配列番号：１乃至４４（但し、配列番号
７、１１及び２５は除く）のいずれか一つで示されるア
ミノ酸配列と実質的に同一のアミノ酸配列とは、配列番
号：１乃至４４（但し、配列番号７、１１及び２５は除
く）のいずれか一つで示される全アミノ酸配列との相同
性の程度が、全体の平均で約７０％以上、好ましくは約
８０％以上、更に好ましくは約９０％以上、特に好まし
くは約９５％以上であるアミノ酸配列を意味する。従っ
て、本発明の配列番号：１乃至４４（但し、配列番号
７、１１及び２５は除く）のいずれか一つで示されるア
ミノ酸配列と実質的に同一のアミノ酸配列から成るポリ
ペプチドとしては、例えば、前記の各配列番号で示され
るアミノ酸配列に対して上記の相同性を有し、各配列番
号で示されるアミノ酸配列から成るポリペプチドの機能
と実質的に同質の生物学的活性（機能）を有するポリペ
プチドを挙げることが出来る。ここで、実質的に同質と
は、それらの活性（機能）が性質的に同質であることを
示す。又、本発明ポリペプチドには、例えば、配列番
号：１乃至４４（但し、配列番号７、１１及び２５は除
く）のいずれか一つで示されるアミノ酸配列中の一部
（好ましくは、１〜２０個程度、より好ましくは１〜１
０個程度、さらに好ましくは数個）のアミノ酸が欠失、
置換又は付加したアミノ酸配列、或いはそれらを組み合
わせたアミノ酸配列から成り、配列番号：１乃至４４
（但し、配列番号７、１１及び２５は除く）のいずれか
一つで示されるアミノ酸配列から成るポリペプチドの機
能と実質的に同質の生物学的活性（機能）を有するポリ
ペプチドも含まれる。

【００１１】上記の配列番号：１乃至４４（但し、配列
番号７、１１及び２５は除く）のいずれか一つで示され
るアミノ酸配列と実質的に同一のアミノ酸配列から成る
ポリペプチド、又はその一部のアミノ酸が欠失、置換又
は付加したアミノ酸配列から成るポリペプチドは、例え
ば、部位特異的変異導入法、遺伝子相同組換え法、プラ
イマー伸長法、及びＰＣＲ法等の当業者に周知の方法を
適宜組み合わせて、容易に作成することが可能である。
尚、その際に、実質的に同質の生物学的活性を有するた
めには、当該ポリペプチドを構成するアミノ酸のうち、
同族アミノ酸（極性・非極性アミノ酸、疎水性・親水性
アミノ酸、陽性・陰性荷電アミノ酸、芳香族アミノ酸な
ど）同士の置換が可能性として考えられる。又、実質的
に同質の生物学的活性の維持のためには、本発明の各ポ
リペプチドに含まれる機能ドメイン内のアミノ酸は保持
されることが望ましい。

【００１２】更に、本発明ＤＮＡは、配列番号：１乃至
４４（但し、配列番号７、１１及び２５は除く）のいず
れか一つで示される塩基配列において、夫々の配列で示
されるアミノ酸配列をコードする塩基配列を含むＤＮ
Ａ、及び、該ＤＮＡとストリンジェントな条件下でハイ
ブリダイズし、各配列で示されるアミノ酸配列から成る
ポリペプチドの機能と同質の生物学的活性（機能）を有
するポリペプチド（蛋白質）をコードするＤＮＡを包含
する。かかる条件下で、配列番号：１乃至４４（但し、
配列番号７、１１及び２５は除く）のいずれか一つで示
される塩基配列において、夫々の配列で示されるアミノ
酸配列をコードする塩基配列を含むＤＮＡとハイブリダ
イズできるＤＮＡとしては、例えば、該ＤＮＡの全塩基
配列との相同性の程度が、全体の平均で約８０％以上、
好ましくは約９０％以上、より好ましくは約９５％以上
である塩基配列を含有するＤＮＡ等を挙げることが出来
る。ハイブリダイゼーションは、カレント・プロトコー
ルズ・イン・モレキュラー・バイオロジー（Current pr
otocols in molecular biology（edited by Frederick
M. Ausubel et al., 1987））に記載の方法等、当業界
で公知の方法あるいはそれに準じる方法に従って行なう
ことができる。また、市販のライブラリーを使用する場
合、添付の使用説明書に記載の方法に従って行なうこと
ができる。ここで、「ストリンジェントな条件」とは、
例えば、６５℃の1mM EDTA ナトリウム、0.5M リン酸水
素ナトリウム（pH7.2）、７％SDS 水溶液中でハイブリ
ダイズさせ、６５℃の1mM EDTA ナトリウム、４０mM リ
ン酸水素ナトリウム（pH7.2）、１％SDS 水溶液中でメ
ンブレンを洗浄する条件でのサザンブロットハイブリダ
イゼーションで本発明ＤＮＡプローブにハイブリダイズ
する程度の条件である。

【００１３】本発明ＤＮＡのクローニングの手段として
は、本発明ポリペプチドの部分等の適当な塩基配列を有
する合成ＤＮＡプライマーを用いてＰＣＲ法によって増
幅するか、または適当なベクターに組み込んだＤＮＡを
本発明ポリペプチドの一部あるいは全領域をコードする
ＤＮＡ断片もしくは合成ＤＮＡを用いて標識したものと
のハイブリダイゼーションによって選別することができ
る。ハイブリダイゼーションの方法は、例えば、上記の
Current protocols in molecular biology（edited by
Frederick M. Ausubel et al., 1987）に記載の方法な
どに従って行なうことができる。また、市販のライブラ
リーを使用する場合、添付の使用説明書に記載の方法に
従って行なうことができる。クローン化されたポリペプ
チドをコードするＤＮＡは目的によりそのまま、または
所望により制限酵素で消化したり、リンカーを付加した
りして使用することができる。該ＤＮＡはその５’末端
側に翻訳開始コドンとしてのＡＴＧを有し、また３’末
端側には翻訳終止コドンとしてのＴＡＡ、ＴＧＡまたは
ＴＡＧを有していてもよい。これらの翻訳開始コドンや
翻訳終止コドンは、適当な合成ＤＮＡアダプターを用い
て付加することもできる。

【００１４】本発明の蛋白質の発現ベクターは、当該技
術分野で公知の方法に従って作成することが出来る。例
えば、（１）本発明ＤＮＡ又は本発明ＤＮＡを含む遺伝
子を含有するＤＮＡ断片を切り出し、（２）該ＤＮＡ断
片を適当な発現ベクター中のプロモーターの下流に連結
することにより製造することができる。ベクターとして
は、大腸菌由来のプラスミド（例、ｐＢＲ３２２，ｐＢ
Ｒ３２５，ｐＵＣ１８，ｐＵＣ１１８）、枯草菌由来の
プラスミド（例、ｐＵＢ１１０，ｐＴＰ５，ｐＣ１９
４）、酵母由来プラスミド（例、ｐＳＨ１９，ｐＳＨ１
５）、λファージなどのバクテリオファージ、レトロウ
イルス，ワクシニアウイルス，バキュロウイルスなどの
動物ウイルス等を利用することが出来る。本発明で用い
られるプロモーターとしては、遺伝子の発現に用いる宿
主に対応した適切なプロモーターであればいかなるもの
でもよい。例えば、宿主が大腸菌である場合は、ｔｒｐ
プロモーター、ｌａｃプロモーター、ｒｅｃＡプロモー
ター、λＰLプロモーター、ｌｐｐプロモーターなど
が、宿主が枯草菌である場合は、ＳＰＯ１プロモータ
ー、ＳＰＯ２プロモーター、ｐｅｎＰプロモーターな
ど、宿主が酵母である場合は、ＰＨＯ５プロモーター、
ＰＧＫプロモーター、ＧＡＰプロモーター、ＡＤＨプロ
モーターなどが好ましい。動物細胞を宿主として用いる
場合は、ＳＲαプロモーター、ＳＶ４０プロモーター、
ＬＴＲプロモーター、ＣＭＶプロモーター、ＨＳＶ-Ｔ
Ｋプロモーターなどが挙げられる。

【００１５】発現ベクターには、以上の他に、所望によ
り当該技術分野で公知の、エンハンサー、スプライシン
グシグナル、ポリＡ付加シグナル、選択マーカー、ＳＶ
４０複製オリジン等を付加することができる。また、必
要に応じて、本発明のＤＮＡにコードされた蛋白質を他
の蛋白質（例えば、グルタチオンＳトランスフェラーゼ
及びプロテインＡ）との融合蛋白質として発現させるこ
とも可能である。このような融合蛋白質は、適当なプロ
テアーゼを使用して切断し、それぞれの蛋白質に分離す
ることが出来る。

【００１６】宿主細胞としては、例えば、エシェリヒア
属菌、バチルス属菌、酵母、昆虫細胞、昆虫、動物細胞
などが用いられる。エシェリヒア属菌の具体例として
は、エシェリヒア・コリ（Escherichia coli）Ｋ１２・
ＤＨ１（Proc. Natl. Acad. Sci. ＵＳＡ，６０巻，１
６０(１９６８)），ＪＭ１０３（Nucleic Acids Resear
ch，９巻，３０９(１９８１)），ＪＡ２２１（Journal
of Molecular Biology，１２０巻，５１７(１９７
８)），及びＨＢ１０１（Journal of Molecular Biolog
y，４１巻，４５９(１９６９)）等が用いられる。バチ
ルス属菌としては、例えば、バチルス・サチルス（Baci
llus subtilis）ＭＩ１１４（Gene，２４巻，２５５(１
９８３)），２０７−２１〔Journal of Biochemistry，
９５巻，８７(１９８４)〕等が用いられる。酵母として
は、例えば、サッカロマイセス セレビシエ（Saccaromy
ces cerevisiae）ＡＨ２２，ＡＨ２２Ｒ-，ＮＡ８７−
１１Ａ，ＤＫＤ−５Ｄ，２０Ｂ−１２、シゾサッカロマ
イセス ポンベ（Schizosaccaromyces pombe）ＮＣＹＣ
１９１３，ＮＣＹＣ２０３６、サッカロマイセス ピキ
ア パストリス（Saccaromycespicjia pastoris）等が用
いられる。動物細胞としては、例えば、サル細胞ＣＯＳ
−７，Ｖero，チャイニーズハムスター細胞ＣＨＯ（以
下、ＣＨＯ細胞と略記），ｄｈｆｒ遺伝子欠損ＣＨＯ細
胞，マウスＬ細胞，マウスＡｔＴ−２０，マウスミエロ
ーマ細胞，ラットＧＨ３，ヒトＦＬ細胞などが用いられ
る。

【００１７】これら宿主細胞の形質転換は、当該技術分
野で公知の方法に従って行うことが出来る。例えば、以
下に記載の文献を参照することが出来る。Proc. Natl.
Acad. Sci. ＵＳＡ，６９巻，２１１０(１９７２)； Ge
ne，１７巻，１０７(１９８２)；Molecular ＆ General
Genetics，１６８巻，１１１(１９７９)；Methods in
Enzymology，１９４巻，１８２−１８７（１９９１）；
Proc. Natl. Acad. Sci. ＵＳＡ），７５巻，１９２９
(１９７８)；細胞工学別冊８ 新 細胞工学実験プロトコ
ール．２６３−２６７（１９９５）（秀潤社発行）；及
び Virology，５２巻，４５６(１９７３)。

【００１８】このようにして得られた、本発明ＤＮＡ又
は本発明ＤＮＡを含む遺伝子を含有する発現ベクターで
形質転換された形質転換体は、当該技術分野で公知の方
法に従って培養することが出来る。例えば、以下に記載
の文献を参照することが出来る。例えば、宿主がエシェ
リヒア属菌の場合、培養は通常約１５〜４３℃で約３〜
２４時間行ない、必要により、通気や撹拌を加えること
もできる。宿主がバチルス属菌の場合、培養は通常、約
３０〜４０℃で約６〜２４時間行ない、必要により通気
や撹拌を加えることもできる。宿主が酵母である形質転
換体を培養する際、培養は通常、ｐＨ約５〜８に調整さ
れた培地を用いて約２０℃〜３５℃で約２４〜７２時間
行ない、必要に応じて通気や撹拌を加えることもでき
る。宿主が動物細胞である形質転換体を培養する際、ｐ
Ｈは約６〜８に調整された培地を用いて、通常約３０℃
〜４０℃で約１５〜６０時間行ない、必要に応じて通気
や撹拌を加えることもできる。

【００１９】上記培養物から本発明ポリペプチド又は蛋
白質を分離精製するには、例えば、培養後、公知の方法
で菌体あるいは細胞を集め、これを適当な緩衝液に懸濁
し、超音波、リゾチームおよび／または凍結融解などに
よって菌体あるいは細胞を破壊したのち、遠心分離やろ
過により蛋白質の粗抽出液を得る。緩衝液の中に尿素や
塩酸グアニジンなどの蛋白質変性剤や、トリトンＸ−１
００^TMなどの界面活性剤が含まれていてもよい。培養液
中に蛋白質が分泌される場合には、培養終了後、公知の
方法で菌体あるいは細胞と上清とを分離し、上清を集め
る。このようにして得られた培養上清、あるいは抽出液
中に含まれる蛋白質の精製は、公知の分離・精製法を適
切に組み合わせて行なうことができる。こうして得られ
た本発明ポリペプチド（蛋白質）は、公知の方法あるい
はそれに準じる方法によって塩に変換することができ、
逆に塩で得られた場合には公知の方法あるいはそれに準
じる方法により、遊離体または他の塩に変換することが
できる。更に、組換え体が産生する蛋白質を、精製前ま
たは精製後に、トリプシン及びキモトリプシンのような
適当な蛋白修飾酵素を作用させることにより、任意に修
飾を加えたり、ポリペプチドを部分的に除去することも
できる。本発明ポリペプチド（蛋白質）又はその塩の存
在は、様々な結合アッセイ及び特異抗体を用いたエンザ
イムイムノアッセイ等により測定することができる。

【００２０】本発明ポリペプチド（蛋白質）は、Ｃ末端
が通常カルボキシル基（−ＣＯＯＨ）またはカルボキシ
レート(−ＣＯＯ-）であるが、Ｃ末端がアミド（−ＣＯ
ＮＨ ₂）またはエステル（−ＣＯＯＲ）であってもよ
い。ここでエステルにおけるＲとしては、例えば、メチ
ル、エチル、ｎ−プロピル、イソプロピルもしくはｎ−
ブチルなどのＣ1-6アルキル基、例えば、シクロペンチ
ル、シクロヘキシルなどのＣ3-8シクロアルキル基、例
えば、フェニル、α−ナフチルなどのＣ6-12アリール
基、例えば、ベンジル、フェネチルなどのフェニル−Ｃ
1-2アルキル基もしくはα−ナフチルメチルなどのα−
ナフチル−Ｃ1-2アルキル基などのＣ7-14アラルキル基
のほか、経口用エステルとして汎用されるピバロイルオ
キシメチルエステルなどが用いられる。

【００２１】本発明ポリペプチド（蛋白質）がＣ末端以
外にカルボキシル基（またはカルボキシレート）を有し
ている場合、カルボキシル基がアミド化またはエステル
化されているものも本発明の蛋白質に含まれる。この場
合のエステルとしては、例えば上記したＣ末端のエステ
ルなどが用いられる。さらに、本発明の蛋白質には、Ｎ
末端のメチオニン残基のアミノ基が保護基（例えば、ホ
ルミル基、アセチル基などのＣ1-6アシル基など）で保
護されているもの、生体内で切断されて生成するＮ末端
のグルタミン酸残基がピログルタミン化したもの、分子
内のアミノ酸の側鎖上にある、例えばＯＨ、ＣＯＯＨ、
ＮＨ₂、ＳＨなどが適当な保護基（例えば、ホルミル
基、アセチル基などのＣ1-6アシル基など）で保護され
ているもの、あるいは糖鎖が結合したいわゆる糖蛋白質
などの複合蛋白質なども含まれる。

【００２２】本発明の蛋白質の部分ポリペプチドとして
は、前記した本発明ポリペプチド（蛋白質）の部分ペプ
チドであって、実質的に同質の活性を有するものであれ
ばいずれのものでもよい。例えば、本発明ポリペプチド
（蛋白質）の構成アミノ酸配列のうち少なくとも１０個
以上、好ましくは５０個以上、さらに好ましくは７０個
以上、より好ましくは１００個以上、最も好ましくは２
００個以上のアミノ酸配列を有し、例えば、本発明のポ
リペプチドの機能と実質的に同質の生物学的活性を有す
るするペプチドなどが用いられる。本発明の部分ポリペ
プチドとしては、例えば、各機能ドメインを含むものが
好ましい。又、本発明の部分ペプチドはＣ末端が通常カ
ルボキシル基（−ＣＯＯＨ）またはカルボキシレート
（−ＣＯＯ-）であるが、前記した本発明の蛋白質のご
とく、Ｃ末端がアミド（−ＣＯＮＨ₂）またはエステル
（−ＣＯＯＲ）であってもよい。さらに、本発明の部分
ペプチドには、前記した本発明の蛋白質と同様に、Ｎ末
端のメチオニン残基のアミノ基が保護基で保護されてい
るもの、Ｎ端側が生体内で切断され生成したグルタミル
基がピログルタミン酸化したもの、分子内のアミノ酸の
側鎖上の置換基が適当な保護基で保護されているもの、
あるいは糖鎖が結合したいわゆる糖ペプチドなどの複合
ペプチドなども含まれる。本発明の部分ペプチドは、例
えば、試薬、実験の際の標準物質、又は免疫源若しくは
その一部として使用することが出来る。

【００２３】本発明ポリペプチド（蛋白質）又はその部
分ペプチドの塩としては、とりわけ生理学的に許容され
る酸付加塩が好ましい。この様な塩としては、例えば、
無機酸（例えば、塩酸、リン酸、臭化水素酸、硫酸）と
の塩、あるいは有機酸（例えば、酢酸、ギ酸、プロピオ
ン酸、フマル酸、マレイン酸、コハク酸、酒石酸、クエ
ン酸、リンゴ酸、蓚酸、安息香酸、メタンスルホン酸、
ベンゼンスルホン酸）との塩などが用いられる。

【００２４】本発明ポリペプチド（蛋白質）、その部分
ペプチドもしくはそれらの塩またはそれらのアミド体
は、当該技術分野で公知の化学合成方法を用いて調製す
ることも出来る。例えば、通常市販されている蛋白質合
成用樹脂を用い、α−アミノ基と側鎖官能基を適当に保
護したアミノ酸を、目的とする蛋白質の配列通りに、当
業界において自体公知の各種縮合方法に従い、樹脂上で
縮合させる。反応の最後に樹脂から蛋白質を切り出すと
同時に各種保護基を除去し、さらに高希釈溶液中で分子
内ジスルフィド結合形成反応を実施し、目的の蛋白質、
その部分ペプチドまたはそれらのアミド体を取得する。
上記した保護アミノ酸の縮合に関しては、例えば、DC
C、N,N'-ジイソプロピルカルボジイミド、及びN-エチル
-N'-(3-ジメチルアミノプロリル）カルボジイミドのよ
うなカルボジイミド類に代表される蛋白質合成に使用で
きる各種活性化試薬を用いることができる。これらによ
る活性化にはラセミ化抑制添加剤（例えば、HOBt, HOOB
t)とともに保護アミノ酸を直接樹脂に添加するかまた
は、対称酸無水物またはHOBtエステルあるいはHOOBtエ
ステルとしてあらかじめ保護アミノ酸の活性化を行なっ
た後に樹脂に添加することができる。

【００２５】保護アミノ酸の活性化や樹脂との縮合に用
いられる溶媒としては、酸アミド類、ハロゲン化炭化水
素類、アルコール類、スルオキシド類、及びエーテル類
等、当業界において蛋白質縮合反応に使用しうることが
知られている溶媒から適宜選択されうる。反応温度は蛋
白質結合形成反応に使用され得ることが知られている範
囲から適宜選択される。活性化されたアミノ酸誘導体は
通常１.５〜４倍過剰で用いられる。ニンヒドリン反応
を用いたテストの結果、縮合が不十分な場合には保護基
の脱離を行うことなく縮合反応を繰り返すことにより十
分な縮合を行なうことができる。反応を繰り返しても十
分な縮合が得られないときには、無水酢酸またはアセチ
ルイミダゾールを用いて未反応アミノ酸をアセチル化し
て、後の反応に影響を及ぼさないようにすることができ
る。原料の各アミノ基、カルボキシル基、及びセリン水
酸基等の保護基としても、当該技術分野において、通常
使用される基を使用することができる。原料の反応に関
与すべきでない官能基の保護ならびに保護基、およびそ
の保護基の脱離、反応に関与する官能基の活性化などは
公知の基または公知の手段から適宜選択しうる。

【００２６】本発明の部分ペプチドまたはそれらの塩
は、当該技術分野において自体公知のペプチドの合成法
に従って、あるいは本発明の蛋白質を適当なペプチダー
ゼで切断することによって製造することができる。ペプ
チドの合成法としては、例えば、固相合成法、液相合成
法のいずれによっても良い。公知の縮合方法や保護基の
脱離としては、例えば、以下の（１）〜（３）に記載さ
れた方法が挙げられる。 （１）泉屋信夫他、ペプチド合成の基礎と実験、 丸善
(株) （1975年） （２）矢島治明 および榊原俊平、生化学実験講座 1、
蛋白質の化学IV、 205、(1977年) （３）矢島治明監修、続医薬品の開発 第14巻 ペプチド
合成 広川書店 反応後の精製も自体公知の方法、例えば、溶媒抽出・蒸
留・カラムクロマトグラフィー・液体クロマトグラフィ
ー・再結晶などを組み合わせて本発明の部分ペプチドを
精製単離することができる。上記方法で得られる部分ペ
プチドが遊離体である場合は、公知の方法によって適当
な塩に変換することができるし、逆に塩で得られた場合
は、公知の方法によって遊離体に変換することができ
る。

【００２７】本発明ポリペプチド（蛋白質）、その部分
ペプチドまたはそれらの塩に対する抗体は、それらを認
識し得るものであれば、ポリクローナル抗体、モノクロ
ーナル抗体の何れであってもよい。本発明ポリペプチド
（蛋白質）、その部分ペプチドまたはそれらの塩に対す
る抗体は、本発明ポリペプチド（蛋白質）又はその部分
ペプチドを抗原として用い、公知の抗体または抗血清の
製造法に従って製造することができる。本発明の抗体
は、体液や組織などの被検体中に存在する本発明ポリペ
プチド（蛋白質）等を検出するために使用することがで
きる。また、これらを精製するために使用する抗体カラ
ムの作製、精製時の各分画中の本発明ポリペプチド（蛋
白質）の検出、被検細胞内における本発明ポリペプチド
（蛋白質）の挙動の分析などのために使用することがで
きる。

【００２８】更に、本発明の抗体は、公知の方法による
被検液中の本発明ポリペプチド（蛋白質）等の定量、特
に、モノクローナル抗体を使用したサンドイッチ免疫測
定法による定量、及び組織染色等による検出などに使用
することができる。それによって、例えば、本発明ポリ
ペプチド（蛋白質）等が関与する疾病の診断を行なうこ
とができる。これらの目的には、抗体分子そのものを用
いてもよく、また、抗体分子のＦ(ａｂ')2 、Ｆａｂ'、
あるいはＦａｂ画分を用いてもよい。本発明の抗体を用
いる本発明の蛋白質等の定量法は、特に制限されるべき
ものではなく、被測定液中の抗原量（例えば、蛋白質
量）に対応した抗体、抗原もしくは抗体−抗原複合体の
量を化学的または物理的手段により検出し、これを既知
量の抗原を含む標準液を用いて作製した標準曲線より算
出する測定法であれば、いずれの測定法を用いてもよ
い。例えば、ネフロメトリー、競合法、イムノメトリッ
ク法およびサンドイッチ法が好適に用いられるが、感
度、特異性の点で、後述するサンドイッチ法を用いるの
が好ましい。標識物質を用いる測定法に用いられる標識
剤としては、当該技術分野で公知の、例えば、放射性同
位元素、酵素、蛍光物質、発光物質などを用いることが
出来る。

【００２９】これらの測定・検出方法に関する一般的な
技術手段の詳細については、総説、成書などを参照する
ことができる。例えば、入江 寛編「続ラジオイムノア
ッセイ〕（講談社、昭和５４年発行）、石川栄治ら編
「酵素免疫測定法」（第３版）（医学書院、昭和６２年
発行）、「Methods in ENZYMOLOGY」Vol. 70(Immunoche
mical Techniques(Part A))、 同書 Vol. 73(Immunoche
mical Techniques(PartB))、 同書 Vol. 74(Immunochem
ical Techniques(Part C))、 同書 Vol. 84(Immunochem
ical Techniques(Part D:Selected Immunoassays))、
同書 Vol. 92(Immunochemical Techniques(Part E:Mono
clonal Antibodies and General Immunoassay Method
s))、 同書 Vol. 121(Immunochemical Techniques(Part
I:HybridomaTechnology and Monoclonal Antibodies))
(以上、アカデミックプレス社発行)などを参照すること
ができる。

【００３０】本発明ポリペプチド（蛋白質）又はその部
分ポリペプチドをコードするＤＮＡに実質的に相補的な
塩基配列を有するアンチセンスオリゴヌクレオチド（Ｄ
ＮＡ）としては、当該ＤＮＡの塩基配列に実質的に相補
的な塩基配列を有し、該ＤＮＡの発現を抑制し得る作用
を有するものであれば、いずれのアンチセンスＤＮＡで
あってもよい。実質的に相補的な塩基配列とは、例え
ば、本発明ＤＮＡに相補的な塩基配列の全塩基配列また
は部分塩基配列と好ましくは約９０以上、より好ましく
は約９５％以上、最も好ましくは１００％の相同性を有
する塩基配列などが挙げられる。又、これらアンチセン
スＤＮＡと同様の作用を有する核酸配列（ＲＮＡまたは
ＤＮＡの修飾体）も本発明でいうアンチセンスＤＮＡに
含まれる。これらのアンチセンスＤＮＡは、公知のＤＮ
Ａ合成装置などを用いて製造することができる。

【００３１】更に、本発明ポリペプチド（蛋白質）等
は、これら物質と特異的に相互作用する化合物をスクリ
ーニングする為の試薬として有用である。すなわち、本
発明は、本発明ポリペプチド（蛋白質）、その部分ペプ
チド若しくはそれらの塩、又はそれらに対する抗体を用
いることを特徴とする、該物質又はそれらの塩と特異的
に相互作用する化合物のスクリーニング方法、及びその
為のスクリーニング用キットを提供する。本発明のスク
リーニング方法またはスクリーニング用キットを用いて
同定される化合物またはその塩は、上記した試験化合物
から選ばれた化合物であり、本発明ポリペプチド（蛋白
質）等と相互作用し、その生物学的活性を調節、阻害、
促進、又は拮抗等する化合物である。該化合物またはそ
の塩は、本発明の蛋白質等の活性に直接作用するもので
あってもよいし、本発明ポリペプチド（蛋白質）等の発
現に作用することによって間接的に本発明ポリペプチド
（蛋白質）等の活性に作用するものであってもよい。該
化合物の塩としては、例えば、薬学的に許容可能な塩な
どが用いられる。例えば、無機塩基との塩、有機塩基と
の塩、無機酸との塩、有機酸との塩、塩基性または酸性
アミノ酸との塩などがあげられる。本発明ポリペプチド
（蛋白質）等の生物学的活性を阻害する化合物も上記各
種疾病に対する治療・予防剤などの医薬として使用でき
る可能性がある。

【００３２】本発明ＤＮＡ及び該ＤＮＡを含む遺伝子を
プローブとして使用することにより、本発明ポリペプチ
ド又はその部分ペプチドをコードするＤＮＡまたはｍＲ
ＮＡの異常（遺伝子異常）を検出することができるの
で、例えば、該ＤＮＡまたはｍＲＮＡの損傷、突然変異
あるいは発現低下や、該ＤＮＡまたはｍＲＮＡの増加あ
るいは発現過多などの遺伝子診断剤として有用である。
本発明のＤＮＡを用いる上記の遺伝子診断は、例えば、
公知のノーザンハイブリダイゼーションやＰＣＲ−ＳＳ
ＣＰ法（Genomics，第５巻，８７４〜８７９頁（１９８
９年）、Proceedings of the National Academy of Sci
ences of the United States of America，第８６巻，
２７６６〜２７７０頁（１９８９年））などにより実施
することができる。更に、本発明ＤＮＡ又は遺伝子に異
常があったり、欠損している場合あるいは発現量が減少
している場合、生体内において正常な機能を発揮できな
い患者に対しては、公知手段に従って（１）レトロウイ
ルスベクター、アデノウイルスベクター、アデノウイル
スアソシエーテッドウイルスベクターなどの適当なベク
ターをベヒクルとして使用する遺伝子治療によって、本
発明ＤＮＡ又は遺伝子を該患者体内に導入し、発現させ
るか、又は（２）本発明の蛋白質等を該患者に注入する
こと等によって、該患者において本発明の蛋白質等の機
能を発揮させることができるものと考えられる。本発明
ＤＮＡ又は遺伝子を、該ＤＮＡを単独、又は、摂取促進
のための補助剤とともに、遺伝子銃やハイドロゲルカテ
ーテルのようなカテーテルによって投与することも可能
である。

【００３３】本明細書および図面において、塩基やアミ
ノ酸などを略号で表示する場合、ＩＵＰＡＣ−ＩＵＢ C
ommision on Biochemical Nomenclature による略号あ
るいは当該分野における慣用略号に基づくものであり、
またアミノ酸に関し光学異性体があり得る場合は、特に
明示しなければＬ体を示すものとする。

【００３４】

【実施例】以下に、実施例により本発明をさらに具体的
に説明するが、本発明はそれに限定されるものではな
い。なお、実施例における各種遺伝子操作は、上記のCu
rrent protocols in molecular biology（edited by Fr
ederick M. Ausubel et al.,1987）に記載されている方
法に従った。

【００３５】（１）ヒト成人全脳、ヒト成人海馬及びヒ
ト胎児全脳由来ｃＤＮＡライブラリーの構築 ＮｏｔＩ部位を有するオリゴヌクレオチド（ＧＡＣＴＡ
ＧＴＴＣＴＡＧＡＴＣＧＣＧＡＧＣＧＧＣＣＧＣＣＣ
（Ｔ）_１５）（インビトロジェン）をプライマーとし
て、ヒト成人全脳、ヒト成人海馬及びヒト胎児全脳由来
ｍＲＮＡ（クローンテック社）を鋳型にSuperScriptII
逆転写酵素キット（インビトロジェン）で２本鎖ｃＤＮ
Ａを合成した。ＳａｌＩ部位を有するアダプター（イン
ビトロジェン）をｃＤＮＡとライゲーションした。その
後、ＮｏｔＩ消化し、１％濃度の低融解アガロース電気
泳動により、３ｋｂ以上のＤＮＡ断片を精製した。精製
ｃＤＮＡ断片を、ＳａｌＩ−ＮｏｔＩ制限酵素処理した
pBluescript IISK＋ プラスミドとライゲーションし
た。大腸菌 ElectroMax DH10B 株（インビトロジェン）
にエレクトロポレーション法によりこの組換えプラスミ
ドを導入した。

【００３６】（２）スクリーニング 次いで、こうして構築したｃＤＮＡライブラリーからラ
ンダムにクローンをピックアップし、メンブランにスポ
ッティングした。次に、これまでに本発明者等によって
既に全長の解析が行われている約1,300個のクローンの
塩基配列に基づき作成したオリゴＤＮＡ（各２１塩基）
の混合物の各３’末端をターミナルトランスフェラーゼ
でＤＩＧラベルし、これらをプルーブとして使用してド
ットハイブリダイゼーション（Current protocols in m
olecular biology（edited by Frederick M. Ausubel e
t al., 1987））により、重複クローン（繰り返し出て
くるクローン）を除いた。次に、インビトロでの転写翻
訳（プロメガ社TNT T7 Quick Coupled Transcription/T
ranslation System cat.no.L1107）を行い、５０ｋＤａ
以上の産物が認められるクローンを選択した。次に、選
択したクローンの末端塩基配列を決定し、得られた配列
をクエリーとして相同検索プログラムBLASTN 2.0.14 (A
ltschul, Stephen F., Thomas L. Madden, Alejandro
A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Mill
er, andDavid J. Lipman (1997), "Gapped BLAST and P
SI-BLAST: a new generation of protein database sea
rch programs", Nucleic Acids Res. 25:3389-3402)を
用いて、nr(All GenBank+EMBL+DDBJ+PDB sequences (bu
t no EST, STS,GSS, orphase 0,1 or 2 HTGS sequence
s))データベースに対して相同検索を行った。その結
果、相同遺伝子が存在しなかったもの、即ち、新規遺伝
子であるものについて全塩基配列を決定した。配列決定
には、ＰＥアプライドバイオシステム社製のＤＮＡシー
クエンサー（ABI PRISM377）と同社製反応キットを使用
した。大部分の配列はショットガンクローンをダイター
ミネーター法を用いて決定した。一部の塩基配列につい
ては、決定した塩基配列を元にしてオリゴヌクレオチド
を合成し、プライマーウォーキング法で決定した。

【００３７】このようにして新規ＤＮＡ又は遺伝子のス
クリーニングを行なった。その結果、配列表の配列番号
１乃至４４（但し、配列番号７、１１及び２５は除く）
のいずれか一つに示された新規ＤＮＡ又は遺伝子が検出
された。これらの新規ＤＮＡ又は遺伝子について、上記
の配列決定方法によりその塩基配列を決定した。本発明
ＤＮＡ又は遺伝子を有するクローンの名称は表１乃至表
３に示されている。

【００３８】（３）本発明ＤＮＡの相同性検索 次に、こうして得られた全塩基配列に基づき、クローン
のアミノ酸配列を既知配列ライブラリーnr release 122
に対して解析プログラムBLASTP 2.0.14 (Altschul, Ste
phen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang,Zheng Zhang, Webb Miller, and David
J. Lipman (1997), "Gapped BLAST andPSI-BLAST: a ne
w generation of protein database search programs",
Nucleic Acids Res. 25:3389-3402)を用いて検索した
ところ表４〜表６に示した各相同遺伝子と相同性を示す
ことが明らかになった。尚、表４〜表６には、これら相
同遺伝子に関する情報、即ち、その名称、データベース
ＩＤ、生物種、蛋白質長、及び記載文献が挙げられてい
る。又、これら各表中の「生物種」の略号の意味は表７
で説明されている。

【００３９】更に、各クローンに含まれる本発明ＤＮＡ
又は遺伝子と表４〜表６に示した各相同遺伝子との相同
性に関する各種データを表８〜表９にまとめた。これら
表中の各項目の意味は以下の通りである。 「相同領域 クローン」クローンの相同領域の起点及び
終点 「相同領域 相同遺伝子」相同遺伝子の相同領域の起点
及び終点 「Score」この値が高ければ高いほど信頼度が高い 「E-value」この値が0に近ければ近いほど信頼度が高い 「相同性」相同領域のアミノ酸残基の一致の割合 「相同範囲率」相同遺伝子中の相同領域の割合

【００４０】（４）各種ドメインの検索 次に、クローンに含まれるＤＮＡがコードするアミノ酸
配列中から、Pfam 6.0に含まれる検索ツールPfam HMM v
er 2.1 Search (HMMPFAM) (Sonnhammer ELL, Eddy SR,
Birney E, Bateman A, Durbin R (1998) Pfam: multipl
e sequence alignments and HMM-profiles of protein
domains, Nucleic Acids Research 26:320-322)を用い
て機能ドメインを検索した。更に、膜蛋白予測プログラ
ムであるSOSUI system (ver. 1.0 / 10, Mar., 1996)
(Takatsugu Hirokawa, Seah Boon-Chieng and Shigeki
Mitaku, SOSUI: Classification and Secondary Struct
ure Prediction System for Membrane Proteins, Bioin
formatics (formerly CABIOS) 1998 May;14(4):378-37
9.) を用いて膜貫通ドメインを検索した。これらの検出
された機能ドメイン及び膜貫通ドメインを表１０〜表１
９にそれぞれのクローンについて示した。これら表中の
各項目の意味は以下の通りである。 「機能ドメイン」Pfam SOSUIにより検出されたドメイン 「クローン from」機能ドメインの起点 「クローン to」機能ドメインの終点 「相同遺伝子 from」機能ドメインの起点 「相同遺伝子 to」機能ドメインの終点 「Score(Pfamのみ)」この値が高ければ高いほど信頼度
が高い 「Exp(Pfamのみ)」この値が0に近ければ近いほど信頼度
が高い 又、各機能ドメインの完全標記を表２０〜表２１に示し
た。

【００４１】（５）発現部位 RT-PCR Coupled ELISAを用いて、組織と脳の部位での発
現を、それぞれで一番強い発現を示したものを表２２〜
表２３に示した。尚、組織及び脳の部位の完全標記を表
２４に示した。 （６）染色体位置 クローンのDNA配列に対応する、既知配列ライブラリーG
enbank release122中のヒトゲノム配列を解析プログラ
ムBLASTN 2.0.14 (Altschul, Stephen F., Thomas L. M
adden, Alejandro A. Schaffer, Jinghui Zhang, Zheng
Zhang, Webb Miller, and David J. Lipman (1997), "
Gapped BLAST and PSI-BLAST: a new generation of pr
otein database search programs", Nucleic Acids Re
s. 25:3389-3402)を用いて検索した。適合したクローン
の説明(Definition)の中からこのクローンが由来した染
色体の番号の記述を抽出し、これを表２２〜表２３に示
した。

【００４２】以上の、相同性、相同性遺伝子に関する情
報、各種ドメイン、発現部位、及び染色体位置、等に基
づき、当業者であれば、本発明のＤＮＡ又は遺伝子が表
１〜表３に示した各機能を有するものと予測することが
出来る。尚、以下のクローンに含まれる遺伝子が完全長
であることは、以下の理由により判定した。bg00381
は、ヒトのオメガクラスのグルタチオン転移酵素とのア
ミノ酸配列のアラインメントから、ヒトのオメガクラス
のグルタチオン転移酵素の選択的スプライシングの一つ
のタイプの完全長であると考えられる。又、fk03350
は、マウスのネトリン G1とのアミノ酸配列のアライン
メントから、ヒトのネトリン G1の完全長であると考え
られる。又、fk06388は、ウサギのカルシウム依存性のS
olute carrier 蛋白質とのアミノ酸配列のアラインメン
トから、ヒトのカルシウム依存性のSolute carrier 蛋
白質の完全長であると考えられる。

【００４３】本発明で得られた新規なＤＮＡ又は遺伝子
を所謂ＤＮＡチップ等に集積させ、これに、例えば、精
神病等の脳が関与する疾患の患者と対照としての正常人
の血液又は組織等から作成したプローブをハイブリダイ
ゼーションさせることによって、これら疾患の診断、治
療等に役立てることが出来る。又、本発明のＤＮＡ若し
くは遺伝子又はそれらの一部の塩基配列に基づき作成し
た合成ＤＮＡプライマーを使用し、ヒトの血液又は組織
から抽出した染色体ＤＮＡを用いてＰＣＲを行い、その
産物の塩基配列を決定することにより、本発明のＤＮＡ
又は遺伝子中にある個体によって異なる一塩基の変異、
即ち、ｃＳＮＰｓを見出すことが出来る。これにより、
個体の体質等が予測され、各自に適した医薬の開発等が
可能となる。又、クロスハイブリダイゼーションによ
り、マウス等のモデル生物における本発明のＤＮＡ又は
遺伝子に対するオルソログ（ホモログ、カウンターパー
ト）遺伝子を単離し、例えば、これら遺伝子をノックア
ウトすることによってヒトの疾患モデル動物を作成し、
ヒトの病因となる遺伝子を探索・同定することも可能で
ある。更に、本発明のＤＮＡ又は遺伝子に対する抗体を
網羅的に作成し、それらを集積させて所謂ＰＲＯＴＥＩ
Ｎチップを作成し、患者と正常人との蛋白質発現量の差
異を検出する等のプロテオーム解析から、病気の診断・
治療等に役立てることが出来る。

【００４４】

【表１】

【００４５】

【表２】

【００４６】

【表３】

【００４７】

【表４】

【００４８】

【表５】

【００４９】

【表６】

【００５０】

【表７】

【００５１】

【表８】

【００５２】

【表９】

【００５３】

【表１０】

【００５４】

【表１１】

【００５５】

【表１２】

【００５６】

【表１３】

【００５７】

【表１４】

【００５８】

【表１５】

【００５９】

【表１６】

【００６０】

【表１７】

【００６１】

【表１８】

【００６２】

【表１９】

【００６３】

【表２０】

【００６４】

【表２１】

【００６５】

【表２２】

【００６６】

【表２３】

【００６７】

【表２４】

【００６８】

【配列表】 SEQUENCE LISTING <110> Kazusa DNA Research Institute <120> Novel Genes and Proteins Encoded by the Genes <130> AB02016 <160> 44 <210> 1 <211> 5302 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2278)..(2700) <400> 1 ctgagatgtt gtctgaactt ccagtcactc attgtgaagt ggaactgcag taactacatt 60 tggtgcaaaa tttcatgtcg atggaagctg atatgtcctg cagtctcaga gggacagaat 120 tctggtgtat ctccctttgg cctatgagga atgaagattt aggctctgag ggttttgtca 180 aaatttataa gatgtaagaa atggggacgt ctttaggcca tgaggcaagg cctagtggtg 240 taaagaaaca gcttctgacc cagggctcat gaagtcagca tggtgtcagg ggcgatggtg 300 gagtgagcat agtatggttt ttggaaccat tccttcctct tatttcttca caggccaggt 360 atgcacaacc agggggcatc tcgggcctga tgagcagagt cctgaagaga caaaggggca 420 atcctgagga agagacttga cagggaggaa ggagccacca atttcactcc tgagggaatt 480 cttcctcccc agtaaaccat aggattttcc tttgtctcag tgagagtttt cctgagtgaa 540 gagaaaagag agagaaaggg actgatgtgt tatctgttac caccacctga agtgattctg 600 aaacgttggg ggaaaggaga attatcttca gagtcataag caatccagag gccatggtta 660 cacataagag agtggaagtt cttatctctg gggggtaggc actaggcatt gatattggtt 720 aaagctcatt cactgattac aaagtgagac aaataaatac tccactgcaa gatttattca 780 tgacatttta tttcacacac aattcacttg ccttcacgca aagagctctt ggttccctgc 840 ctatggacac actgtaactg ggtcttccaa attcattctt ctggatgtaa aagaggacat 900 aggcctgttg actcaggaca gaagtgatac cggaggcagt gacctcggca tcatccattt 960 tataccaatg gccttcttga gtttgacata agataagtaa tgtccgttgt gacaactcca 1020 cccagcgtgg accagcacag catagaggac atagacaaga ggtcctgtgt tctgctgaga 1080 catgtatggc tgcatgtcaa ggcactcagg atattgcaca ttcttggcaa gtttgttgcc 1140 tgtgacctca gagaatctct tcaatacaag gatgaggacc ttggcagaag tgtgtaaagt 1200 taacgtcctg gaggcaggcg ccttctggag acaaagacca caatgatagg cattttatcc 1260 attgagttct tcgggcttca ccaactgtta caaagcttgc ttgacactct gagctgcctg 1320 gatatccagg gcgatgtcca ggtaagggtc aaaggtgtct gaaatcccgt ggcagtggaa 1380 acagttgatg tgagatctcc agtaccctcc aaatatttgg tggatgaggg tggtgtcctt 1440 agagtgatta tctaaatgct tgtgcccggg aaggaatgcc tttttcatgg catccacagt 1500 gaacatgaga aattcatggg catcttcctg ctcgcctcta tggaagccag cagccaacac 1560 ctgtgagggc tggatgacat ggccaggact gtggaggggc catgtgatgt gagcttgcat 1620 agtacagagc atgcagcact tgtgacgatg acacgtttga gagtgctccc gggacagcat 1680 gtagttggca aggggcggtg tgtatgtcag gcactgcagg gaagcgttca cgtagcaggt 1740 atttcccata ttctggagcc cagcccccac cgcagcaggt ctcctgctac tcagaggaag 1800 cttctccctg ggagcgagct gtcttgccac aggagccaaa tcatcacaga ggtcgacgcg 1860 ggtctcagat gagagtgatg acttctcaga gagagaagtc cgctggattt cagcaaaagc 1920 tgcatctggc cgagaagatg tgagttttga aaagtggttg aactgccact cacctcccaa 1980 gtagagtgag tcgtcctcca tgtcgcccgg aacaaggatc acaaggtttt tcggctggga 2040 ccgcaggttg cagaaagacg ctatctcttc cgagtcttca aatgacgggc tctctggccg 2100 catcagccct tatataactc acccccacca accgcgaaca ccccacccac ccatcaggtg 2160 cgcgataaac caatcaaata tcagcactca attaaggaat gagtcacagg gtgtgtcccc 2220 ttgcatcgct gggaattcaa cagacacagc ccacatcatg acttctagaa cacctga 2277 atc aaa cta ctc ctc agg ctg ata gac aca tgt aat atg agt gta acc 2325 Ile Lys Leu Leu Leu Arg Leu Ile Asp Thr Cys Asn Met Ser Val Thr 1 5 10 15 ggg ttg gga cag tgg cca cac agt tgc ctt att tta ggt aaa aca atg 2373 Gly Leu Gly Gln Trp Pro His Ser Cys Leu Ile Leu Gly Lys Thr Met 20 25 30 tca ggg aag aaa tct tta cct atg aaa ccg tgt gtg tgt gtg tgt gtg 2421 Ser Gly Lys Lys Ser Leu Pro Met Lys Pro Cys Val Cys Val Cys Val 35 40 45 tgt gtt ttt ctc ccc tac gtg tgg gtc ggc act tcc act gag atc act 2469 Cys Val Phe Leu Pro Tyr Val Trp Val Gly Thr Ser Thr Glu Ile Thr 50 55 60 ggc aca caa gca gag ccc tct tgc agt gtt tgt tct tcc ctt tgg ctc 2517 Gly Thr Gln Ala Glu Pro Ser Cys Ser Val Cys Ser Ser Leu Trp Leu 65 70 75 80 tcc tgg tcc tcc ctt gca gag aag cga gtg tgc cag tgt tca tgg act 2565 Ser Trp Ser Ser Leu Ala Glu Lys Arg Val Cys Gln Cys Ser Trp Thr 85 90 95 cct gat ctg tcg ggt tcg tcg aag aga ggt tta gca ggg agc ttt gct 2613 Pro Asp Leu Ser Gly Ser Ser Lys Arg Gly Leu Ala Gly Ser Phe Ala 100 105 110 gtt cag gat gat ggt ttt tca tcc cac act tgt att ttg att gat gaa 2661 Val Gln Asp Asp Gly Phe Ser Ser His Thr Cys Ile Leu Ile Asp Glu 115 120 125 tca caa gta cgt tgg gag gca ggg tac ctt caa gtt ttc tgacgttgaa 2710 Ser Gln Val Arg Trp Glu Ala Gly Tyr Leu Gln Val Phe 130 135 140 ctcaggcttc gttttgtttt gctcttggag gaatttccag tggtctaagg tgctttcctg 2770 agtggctctt tccaccaagt gctcgtccaa ctcgggtacc tggaggcagg ggtagtctct 2830 cttgagctct ccttgcgttg ctcgcctgtc tgtgtcttca gcgccgaggg ctcttggttc 2890 cctgcctctt gacacactct cactgtgtct ttcccattca ctcttgtgga tgtaaaagag 2950 gacataggcc tgttgactca ggacagaggt gatgccagag gcagtgacct cggcatcatc 3010 cattttatac cactggcctt cttgaacttt gacataagag aagtaatgtc cgttgtgaca 3070 actccacccg gcgtggacca gcacagcata gaggacatag acaagaggtc ctgtgttctg 3130 ctgagacatg tatggctgca tgtcaaggca ctcaggatat tgcacattct tggcaatttt 3190 gttgcctgtg acatcggaga atctcttcaa tacgaggatg aggatcttgg cagaagtgtg 3250 taaagtttac gtcttggagg ccggcgccct ctggagacaa agaccacaat gataggcatt 3310 ctctccattg agttcttcgg gcttcaccaa ctgttccaaa gcttgcttga cactctgagc 3370 ttcctggata tccagggcga tgtccaggta agggccaaaa gtgtctgaaa tgccgtggca 3430 gtggagacac ttgatttgag atctccagta ccctccaaat atttggtgga tgagggtggt 3490 gtccttggag tgatgatcta cctgcttgtg cccgggaagg catgcctttt tcatggcatc 3550 cacagtgaac atgagaaatt caagggcagc ttcctgcttg cctctatgga agccagcagc 3610 caatgcctgt gagggctgga tgacatggcc aggaatgtgg aggggccatg tgatgtgagc 3670 ttccatggta cagagcatgc agcacttgtg acgatgacat gtttgagagt gctcccggga 3730 cagcatgtag ttggcaaggg gcggtgtgta tgtcagacac tgctgggaag cgttcacgta 3790 gcaggtattt cccatattct ggagcccagc ccccaccgca gcaggtctcc tgctactcag 3850 aggaagcttc tccctgggag caagctgtct tgccacaggc gccaaatcat cgcagaagtc 3910 gacgcgggtc tcagttgaga gttgtgactt ctcagggaga gaagtccgct ggatttcagc 3970 aaaggctgca tctggccgag aagatgtgag ttttgaaaag tggttgaact gccactcacc 4030 tcccaagtag agtgagtcgt cctccatgtc gcccggaaca aggatcacaa ggtttttcgg 4090 ctgggacctt atgttgcaga aagactctat ctcttccgag agagtcttca aatgacgagc 4150 tctctggccg catcagccct tatataactc acccccacca acggcgaaca cctcacccac 4210 tcatcaggtg cgcgataagc caatcaaatg tcagcattta attaaggaat gagtcacagg 4270 gtgtgtcccc ttgcatcgct gggaattcaa cagacacagc ccacatcatg acttctagaa 4330 cacctgaatc acattactcc tcaggatgat aggcagatgt aatatgagtg taaccaggtt 4390 gggacagtgg ccacacagtt gccttatttt aggtaaaaca atgtcaggga agaaatcttt 4450 acctatgaag ccgtgtgtgt gtgtgtttgt gtgtttgtgt gtgtgtgttt gtgctgggat 4510 gaacctccaa gtatgtgctt ttggcagcta ccatcatcct ctcagcgacg gaaagagaag 4570 aagtcggaag tgcgctttct gacctgagaa tagtcaatga agtatagtat ttagcacagc 4630 gtattttttt ccctaataag aaaggagaga tccgtggaaa caaacaaacc ttccagcgat 4690 aagctttcca cgttcagcct attgattctc tatccgaatg aaattagctg ccagtggata 4750 acaagacaag tctttgcatg aaatgctctt ttggaagcta ggttgccaaa taataaagca 4810 tcatatggta gaaacacact gaagtttgaa gagatactca gtgcacaaag tagactgtga 4870 aagactttgt ggaaatcatg cagtcactga gagactaatt gatgacaatc cccaaattta 4930 tgtttgccag gaaagagaga tggtcatgac attgtatagt gaatgatttc ggatgtgcga 4990 tggcagttta agaaaacatg aaacggccgg gcgcggtggc tcacgcctgt aatcccagca 5050 ctttgggagg ccgaggcggg tggatcatga ggtcaggaga tcgagaccat cctggctaac 5110 aaagtgaaac cccgtctcta ctaaaaatac aaaaaattag ccgggcgcgg tggcgggcgc 5170 ctgtagtccc agctactcgg gaggctgagg caggagaatg gcgtgaaccc gggaagcgga 5230 gcttgcagtg agccgagatt gcgccactgc agtccgcagt ccggcctggg cgacagagcg 5290 agaccccgtc tc 5302 <210> 2 <211> 6113 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1779) <400> 2 ggg aag gaa atg aag agc aaa gtg gac acg att gtg aac ttc acc cac 48 Gly Lys Glu Met Lys Ser Lys Val Asp Thr Ile Val Asn Phe Thr His 1 5 10 15 cag cac ttc acc tcc cag ttc gag gtc act gtc tgg gca ccc agg ctc 96 Gln His Phe Thr Ser Gln Phe Glu Val Thr Val Trp Ala Pro Arg Leu 20 25 30 ccc ctg cag att gag atc tca gac acc gag ctg agc cag atc aag ggc 144 Pro Leu Gln Ile Glu Ile Ser Asp Thr Glu Leu Ser Gln Ile Lys Gly 35 40 45 tgg agg atc ccg gtt gct gcc aac aga agg cct acc cgg gaa agc gat 192 Trp Arg Ile Pro Val Ala Ala Asn Arg Arg Pro Thr Arg Glu Ser Asp 50 55 60 gac gag gac gat gag gag aag aag gga cga ggc tgc tcc ctg cag tac 240 Asp Glu Asp Asp Glu Glu Lys Lys Gly Arg Gly Cys Ser Leu Gln Tyr 65 70 75 80 cag cac gcc aca gtg cgt gtc ctc acc cag ttt gtg gcc gag tca cct 288 Gln His Ala Thr Val Arg Val Leu Thr Gln Phe Val Ala Glu Ser Pro 85 90 95 gac tta ggg cag ctg acc tac atg ctg ggc ccc gac tgg cag ttt gac 336 Asp Leu Gly Gln Leu Thr Tyr Met Leu Gly Pro Asp Trp Gln Phe Asp 100 105 110 atc act gac ctt gtg acc gag ttc atg aag gtg gag gag ccg aaa atc 384 Ile Thr Asp Leu Val Thr Glu Phe Met Lys Val Glu Glu Pro Lys Ile 115 120 125 gct cag tta cag gac ggc agg acc ctg gct ggt cgg gag ccg gga ata 432 Ala Gln Leu Gln Asp Gly Arg Thr Leu Ala Gly Arg Glu Pro Gly Ile 130 135 140 acc acg gtg cag gtc ctc tcg ccg ttg tct gac tcc atc ctg gct gag 480 Thr Thr Val Gln Val Leu Ser Pro Leu Ser Asp Ser Ile Leu Ala Glu 145 150 155 160 aag acg gtg att gtc ctg gat gac cga gtc acc atc gcg gag ctg gga 528 Lys Thr Val Ile Val Leu Asp Asp Arg Val Thr Ile Ala Glu Leu Gly 165 170 175 gtg cag ctc gta gct ggc atg tct ctc tcc ctg cag cca cac cga gca 576 Val Gln Leu Val Ala Gly Met Ser Leu Ser Leu Gln Pro His Arg Ala 180 185 190 gac aaa agg gcc atc gtc tcc aca gct gct gcc ctg gat gtt ctt cag 624 Asp Lys Arg Ala Ile Val Ser Thr Ala Ala Ala Leu Asp Val Leu Gln 195 200 205 tcc cca cag cag gaa gca ata gta agt tct tgg att ttg ttc agt gat 672 Ser Pro Gln Gln Glu Ala Ile Val Ser Ser Trp Ile Leu Phe Ser Asp 210 215 220 ggt tcg gtg aca cct tta gac att tac gat cct aag gat tat tct gtt 720 Gly Ser Val Thr Pro Leu Asp Ile Tyr Asp Pro Lys Asp Tyr Ser Val 225 230 235 240 act gtc tca tca ttg gat gaa atg gtg gtg tct gtc cag gca aac ctt 768 Thr Val Ser Ser Leu Asp Glu Met Val Val Ser Val Gln Ala Asn Leu 245 250 255 gag tcc aaa tgg cca att gtg gtt gca gag ggt gaa gga caa ggg cct 816 Glu Ser Lys Trp Pro Ile Val Val Ala Glu Gly Glu Gly Gln Gly Pro 260 265 270 ttg att aag tta gaa atg atg ata agt gaa cct tgt cag aag acc aag 864 Leu Ile Lys Leu Glu Met Met Ile Ser Glu Pro Cys Gln Lys Thr Lys 275 280 285 agg aag agt gtt ctt gcc gtg ggt aaa gga aat gtc aag gtc aaa ttc 912 Arg Lys Ser Val Leu Ala Val Gly Lys Gly Asn Val Lys Val Lys Phe 290 295 300 gaa cca agt agt gat gag cac caa gga ggc agc aat gat att gag ggc 960 Glu Pro Ser Ser Asp Glu His Gln Gly Gly Ser Asn Asp Ile Glu Gly 305 310 315 320 ata aat cgg gaa tat aaa gac cac ctc agt aat tcc ata gag cgc gaa 1008 Ile Asn Arg Glu Tyr Lys Asp His Leu Ser Asn Ser Ile Glu Arg Glu 325 330 335 gga aac cag gag aga gca gtc cag gaa tgg ttc cac cgt ggc aca cct 1056 Gly Asn Gln Glu Arg Ala Val Gln Glu Trp Phe His Arg Gly Thr Pro 340 345 350 gtt ggc caa gag gaa agt acc aac aaa agc aca acc ccc cag tct ccc 1104 Val Gly Gln Glu Glu Ser Thr Asn Lys Ser Thr Thr Pro Gln Ser Pro 355 360 365 atg gaa ggg aag aat aag tta ctc aaa agt ggt ggt cca gat gcc ttt 1152 Met Glu Gly Lys Asn Lys Leu Leu Lys Ser Gly Gly Pro Asp Ala Phe 370 375 380 aca agc ttc ccc act caa ggg aag tca ccg gac ccc aat aat cct agt 1200 Thr Ser Phe Pro Thr Gln Gly Lys Ser Pro Asp Pro Asn Asn Pro Ser 385 390 395 400 gac ctc aca gtg acc tca agg ggg cta acg gac ttg gag att ggc atg 1248 Asp Leu Thr Val Thr Ser Arg Gly Leu Thr Asp Leu Glu Ile Gly Met 405 410 415 tat gcc ttg ctc tgc gtc ttc tgt ctg gcc att ctg gtc ttc ttg atc 1296 Tyr Ala Leu Leu Cys Val Phe Cys Leu Ala Ile Leu Val Phe Leu Ile 420 425 430 aac tgc gtg gcg ttt gcc tgg aaa tac aga cac aaa agg ttt gct gtg 1344 Asn Cys Val Ala Phe Ala Trp Lys Tyr Arg His Lys Arg Phe Ala Val 435 440 445 agt gag cag ggc aac atc ccc cat tcc cac gac tgg gtc tgg ctt ggg 1392 Ser Glu Gln Gly Asn Ile Pro His Ser His Asp Trp Val Trp Leu Gly 450 455 460 aat gaa gtg gaa ctt ttg gag aac cct gtt gac att aca ctc cca tca 1440 Asn Glu Val Glu Leu Leu Glu Asn Pro Val Asp Ile Thr Leu Pro Ser 465 470 475 480 gag gag tgc aca acc atg ata gac agg ggc ctg cag ttc gag gag agg 1488 Glu Glu Cys Thr Thr Met Ile Asp Arg Gly Leu Gln Phe Glu Glu Arg 485 490 495 aac ttc ctt ctg aat ggc agt tcc cag aag act ttt cat agt caa cta 1536 Asn Phe Leu Leu Asn Gly Ser Ser Gln Lys Thr Phe His Ser Gln Leu 500 505 510 ctc aga ccc tct gac tat gtc tat gag aaa gaa att aaa aat gaa cct 1584 Leu Arg Pro Ser Asp Tyr Val Tyr Glu Lys Glu Ile Lys Asn Glu Pro 515 520 525 atg aat tct tcg ggc cca aag agg aag aga gtc aag ttc act tcc tac 1632 Met Asn Ser Ser Gly Pro Lys Arg Lys Arg Val Lys Phe Thr Ser Tyr 530 535 540 acc acc atc ctc cca gag gac ggc ggc cca tac acc aac tcc atc ctg 1680 Thr Thr Ile Leu Pro Glu Asp Gly Gly Pro Tyr Thr Asn Ser Ile Leu 545 550 555 560 ttt gac agc gat gat aac atc aag tgg gtc tgc caa gat atg ggg ctg 1728 Phe Asp Ser Asp Asp Asn Ile Lys Trp Val Cys Gln Asp Met Gly Leu 565 570 575 ggg gat tca cag gac ttt aga gac tat atg gaa agt ctg caa gac cag 1776 Gly Asp Ser Gln Asp Phe Arg Asp Tyr Met Glu Ser Leu Gln Asp Gln 580 585 590 atg taaactcctt tcttatgttt gtattcacct ttatgccttc tgttttttga 1829 Met atgctggagc agtgagtttg atcagcaata ggggatgatt taacaaagtt tgatttgtgg 1889 aggtctggtg ggattcattt ctaagcaggt aaaagaggtt tggagagcta tagaagctgg 1949 gttttaagtt tggaaatgcc tctaaaacag ccacatgtgg ggactggaga aattctaaga 2009 caacagtttt atggactgcc tggtacgagc tcagtgcaaa tgtattaaac ctgaccccac 2069 agacattgtt agtcatctcg tgacaaatgg ccatgtggaa ttagaaaaga tttgggtgtt 2129 gatttttcta tttctagacc ttttaaagca cagtggacac ttattgcccc ttggcctgag 2189 tttagacata catgaaagat gactgaatgt agctatcctg atttgtcatg agcgctgctc 2249 attattttta tatacatttg cacctgcacc tgttcctttg acctctggaa ttctttttga 2309 aacatgaaga gaagaaattt cagtcttttc cttgagctct gtttgattta cacatgagtt 2369 ttcttccctg ggatttgcca tgccatgtta tttcctgggt ctccatgcag gatgtcaggt 2429 ttttccagtt ttctgcactt catcatctag ggatggtatc caagaagctt attctcactt 2489 tgttttttcc ttccttttgt tgttgaactt tcttgtataa cactgggaca aagggtttta 2549 cttaaaatgt taatatacag tgagggaggg ccatctcttt actgttttct atgtgaagtt 2609 tcaaacattt ggaaaaaagt tgtcaatcac aaacatttat ttttattctc tgcttgttga 2669 aaactcatgg ggaactcctg gagtgcattt ctgagggtaa aaaggcccca acatagctgt 2729 atttatacaa gtgctttgtg gccaacacaa tttactatcc aaactgaagt cttaaagtag 2789 aattgaccta cacagaaagg aaattgccta ggcaatagat gcagattaca ctttccattt 2849 taccagaaca aaagtttttt tttttttaaa taagtagaat gacagttcaa gttagcaata 2909 tatagaaatc catccataca atgaccaaaa taaataaata aataaaactc aatcatgact 2969 ttggcagaga taaaacattg acaagggtgt gcatttgtgg agagaagcag tgggtttccc 3029 cccaaaatcc atacaaataa atgactattc cagaactcaa gaagcagcta ttatagaaaa 3089 aaaaattaaa aaccacagct attgaaaaat caaaacggca agagaaaaaa agaaacaact 3149 cctgcataat gtttaaataa aaatgttatt ttaatagcat catgaatggt cttaaggcaa 3209 aaatttcaga ttagcaaaat gtgatgacat atttattaag attgtattat tggaaatgta 3269 gacactggac tagtatgcct cattatgagc tttactgagc catttgcatc tctaagaaat 3329 atgattttaa aggcccaaag taggaaggat ctgcaggggg tcacctgaag cagtgccctg 3389 actccaaatg gctgataact gagctaatcc aaggagaggc gttcagttgt tctcttatta 3449 tagatttcct tgggtgggaa catgacaacc ccgcctcctc tagccatgac gtggcagcca 3509 aaaagttctt cctgtatctc tggcccacag gactgtagtg tgtttgggaa cagtgctgaa 3569 attgcaagtg atgtaggcct gacctccaga gcccagcgtt cagttagttg tataaaatgg 3629 ggcttaggaa ccgaagctga tgaagttcca aaagtagttc agtttgatgg gataaggaag 3689 caaggagagc caggcattag ctgcaaaagg agcttgcaga gagatggctg acactttatg 3749 ggaagattcc tcagtcagcc aaaagctttt caaagagttt ggtgcagagg tagctcagag 3809 ccaaccatcc aggaccgaag aaagctcatg tgctgattga cacatagcta tccaggtgag 3869 tcggctcctt ctatgaggct tttcaatcgt ctctcccttt ggatctctgg cattccagaa 3929 agactgggaa ttcatttctg aaaatgatga acctccgctg aaacggggag gaaatctctt 3989 acacacatac agcagggtcc tgcccactgg taaagtgaga cgttgggtag ggggtgtaac 4049 tggggaggag gtgaaggaaa ttatccctgc catggggagt gttattcagg aacataaaaa 4109 ttagagcatt ccctctgatg gcagtgcttg acggggtgca gggaacaaac tggggagcgt 4169 tcaaacatgc cagtggtttc tcagcagggc tggaaactgg ccacagtcct gaagatgctt 4229 cttgtgacaa cttagagtca ctgggagtca cacagctcct gtgtagccgc ctttgctcct 4289 ctgtgttaaa acccagtcag ttcaaaataa caatcaaatg gaaggccatg ggggaagggt 4349 tccttccacc atataaccca cacccagatg tatataaacg catatacata catatacctg 4409 tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg aatactgaag agccagacaa caaactattt 4469 agtaagaatc aacagtgact gtcaattgtt ctcagatttg gcatggatac tatttctcat 4529 gaaataatgt cattaaagta tttcctcctc taaatatttc ctgaagatca taaaccatgg 4589 gttatagcac cttgttttcc agctagtcaa tatacaacta ttaggtgctg tgccccaaaa 4649 tatctaaaat gggggtaaag atataaacta ttaagccatg aaatctaatt ttctggggac 4709 catgcatttg cctggatttt ccaggatttt atggctgata gacccaaatt attagtcttg 4769 ataaacaacc tgaaccaaac atttataaag tcccttcctc tcccatggga atggaatgct 4829 cagactcctg ctgagggaga caccagcaag cctcttgaga aggcaccaga cagtgaactc 4889 tgtggtcaca tgaagggagg ttcagatgct agacgaccag cgtatgacct ggaaccattg 4949 aggattgcaa ccgctgcctc cagggtccag atgtgctgca gtagagggca gagcacagga 5009 atcaagaagc agctgccaca ccaaagaact gatgcttaaa cacacaggtg tgttgcattt 5069 gagagaaggc aagaagaaaa gacaatagaa ggttaccctg gaaaaacaac acctagcaaa 5129 cctcagaata ctccatgtgt cccaagagaa ggaataattg tctttctagc tgttatatat 5189 tgcacactgg ccaggataaa ttcccagact ataataatcc tgactatgta gacggaagtt 5249 tctatttata aagtcatgca gggggaaagt tgattaattt ttgtcccatt gccacatctg 5309 tagactaagt aacttttaac ttgctaactt ttagaatgtc cacctttgtg cattttcgta 5369 gcattcttgt ttcattattt tagaaagggg tcttcccatt actgggatgt cggggccctg 5429 tcagagaact attattaagg ctctgtgagg gaactgttga gtctcacagc aaggaccaca 5489 gagcgtggtt tcatctgaac cctacaagtc agggacacca gtgtgttttc tactcgagtt 5549 acctaaaaat ggtctcaatt ttccatttca ttctctgtaa atgacacaat agatggttta 5609 tagactcagc agccctcacc ttttattaaa attatatatg tgtgatgtaa tgcatatcac 5669 ctgtcatgta aagggacggt atggatggtg gaaaagttat gctaaaatat ggattgcaga 5729 tatttttgta tgtaatatag gcaatataat gaaacaccga gttttttaaa gtgaaagcat 5789 gcaaaatcgt agcttttaaa tgtacagaca tcccactcaa aaatatctaa actgatagtg 5849 ggaaaaacat ttgagaccta gtaacatcat gaaatgcact gaatttggaa ttctggccta 5909 gaaaggctgt ggcttatgtt gggattgatg atggaatctg ccagaacatt ttcatcttat 5969 tcttcttgac ttttggattt ttttcttttc tttttttctg gaaatatttc ggaaataaag 6029 tgacttcatt tttcagcata aaagtatatt ctaaccacag ggtaacacat cgtttttaac 6089 atgaaaataa acatttaaac attc 6113 <210> 3 <211> 5213 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3)..(5213) <400> 3 ag cgg ttc ggg cca cag acg ctg gag cgc atc aca cgg gac gac gcg 47 Arg Phe Gly Pro Gln Thr Leu Glu Arg Ile Thr Arg Asp Asp Ala 1 5 10 15 gcc atc tgc acc acc gag tac tca cgc atc gtg ccc ctg gag aac gga 95 Ala Ile Cys Thr Thr Glu Tyr Ser Arg Ile Val Pro Leu Glu Asn Gly 20 25 30 gag atc gtg gtg tcc ctg gtg aac gga cgt ccg ggc gcc atg aat ttc 143 Glu Ile Val Val Ser Leu Val Asn Gly Arg Pro Gly Ala Met Asn Phe 35 40 45 tcc tac tcg ccg ctg cta cgt gag ttc acc aag gcc acc aac gtc cgc 191 Ser Tyr Ser Pro Leu Leu Arg Glu Phe Thr Lys Ala Thr Asn Val Arg 50 55 60 ctg cgc ttc ctg cgt acc aac acg ctg ctg ggc cat ctc atg ggg aag 239 Leu Arg Phe Leu Arg Thr Asn Thr Leu Leu Gly His Leu Met Gly Lys 65 70 75 gcg ctg cgg gac ccc acg gtc acc cgc cgg tat tat tac agc atc aag 287 Ala Leu Arg Asp Pro Thr Val Thr Arg Arg Tyr Tyr Tyr Ser Ile Lys 80 85 90 95 gat atc agc atc gga ggc cgc tgt gtc tgc cac ggc cac gcg gat gcc 335 Asp Ile Ser Ile Gly Gly Arg Cys Val Cys His Gly His Ala Asp Ala 100 105 110 tgc gat gcc aaa gac ccc acg gac ccg ttc agg ctg cag tgc acc tgc 383 Cys Asp Ala Lys Asp Pro Thr Asp Pro Phe Arg Leu Gln Cys Thr Cys 115 120 125 cag cac aac acc tgc ggg ggc acc tgc gac cgc tgc tgc ccc ggc ttc 431 Gln His Asn Thr Cys Gly Gly Thr Cys Asp Arg Cys Cys Pro Gly Phe 130 135 140 aat cag cag ccg tgg aag cct gcg act gcc aac agt gcc aac gag tgc 479 Asn Gln Gln Pro Trp Lys Pro Ala Thr Ala Asn Ser Ala Asn Glu Cys 145 150 155 cag tcc tgt aac tgc tac ggc cat gcc acc gac tgt tac tac gac cct 527 Gln Ser Cys Asn Cys Tyr Gly His Ala Thr Asp Cys Tyr Tyr Asp Pro 160 165 170 175 gag gtg gac cgg cgc cgc gcc agc cag agc ctg gat ggc acc tat cag 575 Glu Val Asp Arg Arg Arg Ala Ser Gln Ser Leu Asp Gly Thr Tyr Gln 180 185 190 ggt ggg ggt gtc tgt atc gac tgc cag cac cac acc acc ggc gtc aac 623 Gly Gly Gly Val Cys Ile Asp Cys Gln His His Thr Thr Gly Val Asn 195 200 205 tgt gag cgc tgc ctg ccc ggc ttc tac cgc tct ccc aac cac cct ctc 671 Cys Glu Arg Cys Leu Pro Gly Phe Tyr Arg Ser Pro Asn His Pro Leu 210 215 220 gac tcg ccc cac gtc tgc cgc cgc tgc aac tgc gag tcc gac ttc acg 719 Asp Ser Pro His Val Cys Arg Arg Cys Asn Cys Glu Ser Asp Phe Thr 225 230 235 gat ggc acc tgc gag gac ctg acg ggt cga tgc tac tgc cgg ccc aac 767 Asp Gly Thr Cys Glu Asp Leu Thr Gly Arg Cys Tyr Cys Arg Pro Asn 240 245 250 255 ttc tct ggg gag cgg tgt gac gtg tgt gcc gag ggc ttc acg ggc ttc 815 Phe Ser Gly Glu Arg Cys Asp Val Cys Ala Glu Gly Phe Thr Gly Phe 260 265 270 cca agc tgc tac ccg acg ccc tcg tcc tcc aat gac acc agg gag cag 863 Pro Ser Cys Tyr Pro Thr Pro Ser Ser Ser Asn Asp Thr Arg Glu Gln 275 280 285 gtg ctg cca gcc ggc cag att gtg aat tgt gac tgc agc gcg gca ggg 911 Val Leu Pro Ala Gly Gln Ile Val Asn Cys Asp Cys Ser Ala Ala Gly 290 295 300 acc cag ggc aac gcc tgc cgg aag gac cca agg gtg gga cgc tgt ctg 959 Thr Gln Gly Asn Ala Cys Arg Lys Asp Pro Arg Val Gly Arg Cys Leu 305 310 315 tgc aaa ccc aac ttc caa ggc acc cat tgt gag ctc tgc gcg cca ggg 1007 Cys Lys Pro Asn Phe Gln Gly Thr His Cys Glu Leu Cys Ala Pro Gly 320 325 330 335 ttc tac ggc ccc ggc tgc cag ccc tgc cag tgt tcc agc cct gga gtg 1055 Phe Tyr Gly Pro Gly Cys Gln Pro Cys Gln Cys Ser Ser Pro Gly Val 340 345 350 gcc gat gac cgc tgt gac cct gac aca ggc cag tgc agg tgc cga gtg 1103 Ala Asp Asp Arg Cys Asp Pro Asp Thr Gly Gln Cys Arg Cys Arg Val 355 360 365 ggc ttc gag ggg gcc aca tgt gat cgc tgt gcc ccc ggc tac ttt cac 1151 Gly Phe Glu Gly Ala Thr Cys Asp Arg Cys Ala Pro Gly Tyr Phe His 370 375 380 ttc cct ctc tgc cag ttg tgt ggc tgc agc cct gca gga acc ttg ccc 1199 Phe Pro Leu Cys Gln Leu Cys Gly Cys Ser Pro Ala Gly Thr Leu Pro 385 390 395 gag ggc tgc gat gag gcc ggc cgc tgc cta tgc cag cct gag ttt gct 1247 Glu Gly Cys Asp Glu Ala Gly Arg Cys Leu Cys Gln Pro Glu Phe Ala 400 405 410 415 gga cct cat tgt gac cgg tgc cgc cct ggc tac cat ggt ttc ccc aac 1295 Gly Pro His Cys Asp Arg Cys Arg Pro Gly Tyr His Gly Phe Pro Asn 420 425 430 tgc caa gca tgc acc tgc gac cct cgg gga gcc ctg gac cag ctc tgt 1343 Cys Gln Ala Cys Thr Cys Asp Pro Arg Gly Ala Leu Asp Gln Leu Cys 435 440 445 ggg gcg gga ggt ttg tgc cgc tgc cgc ccc ggc tac aca ggc act gcc 1391 Gly Ala Gly Gly Leu Cys Arg Cys Arg Pro Gly Tyr Thr Gly Thr Ala 450 455 460 tgc cag gaa tgc agc ccc ggc ttt cac ggc ttc ccc agc tgt gtc ccc 1439 Cys Gln Glu Cys Ser Pro Gly Phe His Gly Phe Pro Ser Cys Val Pro 465 470 475 tgc cac tgc tct gct gaa ggc tcc ctg cac gca gcc tgt gac ccc cgg 1487 Cys His Cys Ser Ala Glu Gly Ser Leu His Ala Ala Cys Asp Pro Arg 480 485 490 495 agt ggg cag tgc agc tgc cgg ccc cgt gtg acg ggg ctg cgg tgt gac 1535 Ser Gly Gln Cys Ser Cys Arg Pro Arg Val Thr Gly Leu Arg Cys Asp 500 505 510 aca tgt gtg ccc ggt gcc tac aac ttc ccc tac tgc gaa gct ggc tct 1583 Thr Cys Val Pro Gly Ala Tyr Asn Phe Pro Tyr Cys Glu Ala Gly Ser 515 520 525 tgc cac cct gcc ggt ctg gcc cca gtg gat cct gcc ctt cct gag gca 1631 Cys His Pro Ala Gly Leu Ala Pro Val Asp Pro Ala Leu Pro Glu Ala 530 535 540 cag gtt ccc tgt atg tgc cgg gct cac gtg gag ggg ccg agc tgt gac 1679 Gln Val Pro Cys Met Cys Arg Ala His Val Glu Gly Pro Ser Cys Asp 545 550 555 cgc tgc aaa cct ggg ttc tgg gga ctg agc ccc agc aac ccc gag ggc 1727 Arg Cys Lys Pro Gly Phe Trp Gly Leu Ser Pro Ser Asn Pro Glu Gly 560 565 570 575 tgt acc cgc tgc agc tgc gac ctc agg ggc aca ctg ggt gga gtt gct 1775 Cys Thr Arg Cys Ser Cys Asp Leu Arg Gly Thr Leu Gly Gly Val Ala 580 585 590 gag tgc cag ccg ggc acc ggc cag tgc ttc tgc aag ccc cac gtg tgc 1823 Glu Cys Gln Pro Gly Thr Gly Gln Cys Phe Cys Lys Pro His Val Cys 595 600 605 ggc cag gcc tgc gcg tcc tgc aag gat ggc ttc ttt gga ctg gat cag 1871 Gly Gln Ala Cys Ala Ser Cys Lys Asp Gly Phe Phe Gly Leu Asp Gln 610 615 620 gct gac tat ttt ggc tgc cgc agc tgc cgg tgt gac att ggc ggt gca 1919 Ala Asp Tyr Phe Gly Cys Arg Ser Cys Arg Cys Asp Ile Gly Gly Ala 625 630 635 ctg ggc cag agc tgt gaa ccg agg acg ggc gtc tgc cgg tgc cgc ccc 1967 Leu Gly Gln Ser Cys Glu Pro Arg Thr Gly Val Cys Arg Cys Arg Pro 640 645 650 655 aac acc cag ggc ccc acc tgc agc gag cct gcg agg gac cac tac ctc 2015 Asn Thr Gln Gly Pro Thr Cys Ser Glu Pro Ala Arg Asp His Tyr Leu 660 665 670 ccg gac ctg cac cac ctg cgc ctg gag ctg gag gag gct gcc aca cct 2063 Pro Asp Leu His His Leu Arg Leu Glu Leu Glu Glu Ala Ala Thr Pro 675 680 685 gag ggt cac gcc atg cgc ttt ggc ttc aac ccc ctc gag ttc gag aac 2111 Glu Gly His Ala Met Arg Phe Gly Phe Asn Pro Leu Glu Phe Glu Asn 690 695 700 ttc agc tgg agg ggc tac gcg cag atg gca cct gtc cag ccc agg atc 2159 Phe Ser Trp Arg Gly Tyr Ala Gln Met Ala Pro Val Gln Pro Arg Ile 705 710 715 gtg gcc agg ctg aac ctg acc tcc cct gac ctt ttc tgg ctc gtc ttc 2207 Val Ala Arg Leu Asn Leu Thr Ser Pro Asp Leu Phe Trp Leu Val Phe 720 725 730 735 cga tac gtc aac cgg ggg gcc atg agt gtg agc ggg cgg gtc tct gtg 2255 Arg Tyr Val Asn Arg Gly Ala Met Ser Val Ser Gly Arg Val Ser Val 740 745 750 cga gag gag ggc agg tcg gcc acc tgc gcc aac tgc aca gca cag agt 2303 Arg Glu Glu Gly Arg Ser Ala Thr Cys Ala Asn Cys Thr Ala Gln Ser 755 760 765 cag ccc gtg gcc ttc cca ccc agc acg gag cct gcc ttc atc acc gtg 2351 Gln Pro Val Ala Phe Pro Pro Ser Thr Glu Pro Ala Phe Ile Thr Val 770 775 780 ccc cag agg ggc ttc gga gag ccc ttt gtg ctg aac cct ggc acc tgg 2399 Pro Gln Arg Gly Phe Gly Glu Pro Phe Val Leu Asn Pro Gly Thr Trp 785 790 795 gcc ctg cgt gtg gag gcc gaa ggg gtg ctc ctg gac tac gtg gtt ctg 2447 Ala Leu Arg Val Glu Ala Glu Gly Val Leu Leu Asp Tyr Val Val Leu 800 805 810 815 ctg cct agc gca tac tac gag gcg gcg ctc ctg cag ctg cgg gtg act 2495 Leu Pro Ser Ala Tyr Tyr Glu Ala Ala Leu Leu Gln Leu Arg Val Thr 820 825 830 gag gcc tgc aca tac cgt ccc tct gcc cag cag tct ggc gac aac tgc 2543 Glu Ala Cys Thr Tyr Arg Pro Ser Ala Gln Gln Ser Gly Asp Asn Cys 835 840 845 ctc ctc tac aca cac ctc ccc ctg gat ggc ttc ccc tcg gcc gcc ggg 2591 Leu Leu Tyr Thr His Leu Pro Leu Asp Gly Phe Pro Ser Ala Ala Gly 850 855 860 ctg gag gcc ctg tgt cgc cag gac aac agc ctg ccc cgg ccc tgc ccc 2639 Leu Glu Ala Leu Cys Arg Gln Asp Asn Ser Leu Pro Arg Pro Cys Pro 865 870 875 acg gag cag ctc agc ccg tcg cac ccg cca ctg atc acc tgc acg ggc 2687 Thr Glu Gln Leu Ser Pro Ser His Pro Pro Leu Ile Thr Cys Thr Gly 880 885 890 895 agt gat gtg gac gtc cag ctt caa gtg gca gtg cca cag cca ggc cgc 2735 Ser Asp Val Asp Val Gln Leu Gln Val Ala Val Pro Gln Pro Gly Arg 900 905 910 tat gcc cta gtg gtg gag tac gcc aat gag gat gcc cgc cag gag gtg 2783 Tyr Ala Leu Val Val Glu Tyr Ala Asn Glu Asp Ala Arg Gln Glu Val 915 920 925 ggc gtg gcc gtg cac acc cca cag cgg gcc ccc cag cag ggg ctg ctc 2831 Gly Val Ala Val His Thr Pro Gln Arg Ala Pro Gln Gln Gly Leu Leu 930 935 940 tcc ctg cac ccc tgc ctg tac agc acc ctg tgc cgg ggc act gcc cgg 2879 Ser Leu His Pro Cys Leu Tyr Ser Thr Leu Cys Arg Gly Thr Ala Arg 945 950 955 gat acc cag gac cac ctg gct gtc ttc cac ctg gac tcg gag gcc agc 2927 Asp Thr Gln Asp His Leu Ala Val Phe His Leu Asp Ser Glu Ala Ser 960 965 970 975 gtg agg ctc aca gcc gaa cag gca cgc ttc ttc ctg cac ggg gtc act 2975 Val Arg Leu Thr Ala Glu Gln Ala Arg Phe Phe Leu His Gly Val Thr 980 985 990 ctg gtg ccc att gag gag ttc agc ccg gag ttc gtg gag ccc cgg gtc 3023 Leu Val Pro Ile Glu Glu Phe Ser Pro Glu Phe Val Glu Pro Arg Val 995 1000 1005 agc tgc atc agc agc cac ggc gcc ttt ggc ccc aac agt gcc gcc tgt 3071 Ser Cys Ile Ser Ser His Gly Ala Phe Gly Pro Asn Ser Ala Ala Cys 1010 1015 1020 ctg ccc tcg cgc ttc cca aag ccg ccc cag ccc atc atc ctc agg gac 3119 Leu Pro Ser Arg Phe Pro Lys Pro Pro Gln Pro Ile Ile Leu Arg Asp 1025 1030 1035 tgc cag gtg atc ccg ctg ccg ccc ggc ctc ccg ctg acc cac gcg cag 3167 Cys Gln Val Ile Pro Leu Pro Pro Gly Leu Pro Leu Thr His Ala Gln 1040 1045 1050 1055 gat ctc act cca gcc atg tcc cca gct gga ccc cga cct cgg ccc ccc 3215 Asp Leu Thr Pro Ala Met Ser Pro Ala Gly Pro Arg Pro Arg Pro Pro 1060 1065 1070 acc gct gtg gac cct gat gca gag ccc acc ctg ctg cgt gag ccc cag 3263 Thr Ala Val Asp Pro Asp Ala Glu Pro Thr Leu Leu Arg Glu Pro Gln 1075 1080 1085 gcc acc gtg gtc ttc acc acc cat gtg ccc acg ctg ggc cgc tat gcc 3311 Ala Thr Val Val Phe Thr Thr His Val Pro Thr Leu Gly Arg Tyr Ala 1090 1095 1100 ttc ctg ctg cac ggc tac cag cca gcc cac ccc acc ttc ccc gtg gaa 3359 Phe Leu Leu His Gly Tyr Gln Pro Ala His Pro Thr Phe Pro Val Glu 1105 1110 1115 gtc ctc atc aac gcc ggc cgc gtg tgg cag ggc cac gcc aac gcc agc 3407 Val Leu Ile Asn Ala Gly Arg Val Trp Gln Gly His Ala Asn Ala Ser 1120 1125 1130 1135 ttc tgt cca cat ggc tac ggc tgc cgc acc ctg gtg gtg tgt gag ggc 3455 Phe Cys Pro His Gly Tyr Gly Cys Arg Thr Leu Val Val Cys Glu Gly 1140 1145 1150 cag gcc ctg ctg gac gtg acc cac agc gag ctc act gtg acc gtg cgt 3503 Gln Ala Leu Leu Asp Val Thr His Ser Glu Leu Thr Val Thr Val Arg 1155 1160 1165 gtg ccc gag ggc cgg tgg ctc tgg ctg gat tat gta ctc gtg gtc cct 3551 Val Pro Glu Gly Arg Trp Leu Trp Leu Asp Tyr Val Leu Val Val Pro 1170 1175 1180 gag aac gtc tac agc ttt ggc tac ctc cgg gag gag ccc ctg gat aaa 3599 Glu Asn Val Tyr Ser Phe Gly Tyr Leu Arg Glu Glu Pro Leu Asp Lys 1185 1190 1195 tcc tat gac ttc atc agc cac tgc gca gcc cag ggc tac cac atc agc 3647 Ser Tyr Asp Phe Ile Ser His Cys Ala Ala Gln Gly Tyr His Ile Ser 1200 1205 1210 1215 ccc agc agc tca tcc ctg ttc tgc cga aac gct gct gct tcc ctc tcc 3695 Pro Ser Ser Ser Ser Leu Phe Cys Arg Asn Ala Ala Ala Ser Leu Ser 1220 1225 1230 ctc ttc tat aac aac gga gcc cgt cca tgt ggc tgc cac gaa gta ggt 3743 Leu Phe Tyr Asn Asn Gly Ala Arg Pro Cys Gly Cys His Glu Val Gly 1235 1240 1245 gct aca ggc ccc acg tgt gag ccc ttc ggg ggc cag tgt ccc tgc cat 3791 Ala Thr Gly Pro Thr Cys Glu Pro Phe Gly Gly Gln Cys Pro Cys His 1250 1255 1260 gcc cat gtc att ggc cgt gac tgc tcc cgc tgt gcc acc gga tac tgg 3839 Ala His Val Ile Gly Arg Asp Cys Ser Arg Cys Ala Thr Gly Tyr Trp 1265 1270 1275 ggc ttc ccc aac tgc agg ccc tgt gac tgc ggt gcc cgc ctc tgt gac 3887 Gly Phe Pro Asn Cys Arg Pro Cys Asp Cys Gly Ala Arg Leu Cys Asp 1280 1285 1290 1295 gag ctc acg ggc cag tgc atc tgc ccg cca cgc acc atc ccg ccc gac 3935 Glu Leu Thr Gly Gln Cys Ile Cys Pro Pro Arg Thr Ile Pro Pro Asp 1300 1305 1310 tgc ctg ctg tgc cag ccc cag acc ttt ggc tgc cac ccc ctg gtc ggc 3983 Cys Leu Leu Cys Gln Pro Gln Thr Phe Gly Cys His Pro Leu Val Gly 1315 1320 1325 tgt gag gag tgt aac tgc tca ggg ccc ggc atc cag gag ctc aca gac 4031 Cys Glu Glu Cys Asn Cys Ser Gly Pro Gly Ile Gln Glu Leu Thr Asp 1330 1335 1340 cct acc tgt gac aca gac agc ggc cag tgc aag tgc aga ccc aac gtg 4079 Pro Thr Cys Asp Thr Asp Ser Gly Gln Cys Lys Cys Arg Pro Asn Val 1345 1350 1355 act ggg cgc cgc tgt gat acc tgc tct ccg ggc ttc cat ggc tac ccc 4127 Thr Gly Arg Arg Cys Asp Thr Cys Ser Pro Gly Phe His Gly Tyr Pro 1360 1365 1370 1375 cgc tgc cgc ccc tgt gac tgt cac gag gcg ggc act gcg cct ggc gtg 4175 Arg Cys Arg Pro Cys Asp Cys His Glu Ala Gly Thr Ala Pro Gly Val 1380 1385 1390 tgt gac ccc ctc aca ggg cag tgc tac tgt aag gag aac gtg cag ggc 4223 Cys Asp Pro Leu Thr Gly Gln Cys Tyr Cys Lys Glu Asn Val Gln Gly 1395 1400 1405 ccc aaa tgt gac cag tgc agc ctt ggg acc ttc tca ctg gat gct gcc 4271 Pro Lys Cys Asp Gln Cys Ser Leu Gly Thr Phe Ser Leu Asp Ala Ala 1410 1415 1420 aac ccc aaa ggt tgc acc cgc tgc ttc tgc ttt ggg gcc acg gag cgc 4319 Asn Pro Lys Gly Cys Thr Arg Cys Phe Cys Phe Gly Ala Thr Glu Arg 1425 1430 1435 tgc cgg agc tcg tcc tac acc cgc cag gag ttc gtg gat atg gag gga 4367 Cys Arg Ser Ser Ser Tyr Thr Arg Gln Glu Phe Val Asp Met Glu Gly 1440 1445 1450 1455 tgg gtg ctg ctg agc act gac cgg cag gtg gtg ccc cac gag cgg cag 4415 Trp Val Leu Leu Ser Thr Asp Arg Gln Val Val Pro His Glu Arg Gln 1460 1465 1470 cca ggg acg gag atg ctc cgt gca gac ctg cgg cac gtg cct gag gct 4463 Pro Gly Thr Glu Met Leu Arg Ala Asp Leu Arg His Val Pro Glu Ala 1475 1480 1485 gtg ccc gag gct ttc ccc gag ctg tac tgg cag gcc cca ccc tcc tac 4511 Val Pro Glu Ala Phe Pro Glu Leu Tyr Trp Gln Ala Pro Pro Ser Tyr 1490 1495 1500 ctg ggg gac cgg gtg tca tcc tac ggt ggg acc ctc cgt tat gaa ctg 4559 Leu Gly Asp Arg Val Ser Ser Tyr Gly Gly Thr Leu Arg Tyr Glu Leu 1505 1510 1515 cac tca gag acc cag cgg gga gat gtc ttt gtc ccc atg gag agc agg 4607 His Ser Glu Thr Gln Arg Gly Asp Val Phe Val Pro Met Glu Ser Arg 1520 1525 1530 1535 ccg gat gtg gtg ctg cag ggc aac cag atg agc atc aca ttc ctg gag 4655 Pro Asp Val Val Leu Gln Gly Asn Gln Met Ser Ile Thr Phe Leu Glu 1540 1545 1550 ccg gca tac ccc acg cct ggc cac gtt cac cgt ggg cag ctg cag ctg 4703 Pro Ala Tyr Pro Thr Pro Gly His Val His Arg Gly Gln Leu Gln Leu 1555 1560 1565 gtg gag ggg aac ttc cgg cat acg gag act cgc aac act gtg tcc cgc 4751 Val Glu Gly Asn Phe Arg His Thr Glu Thr Arg Asn Thr Val Ser Arg 1570 1575 1580 gag gag ctc atg atg gtg ctg gcc agc ctg gag cag ctg cag atc cgt 4799 Glu Glu Leu Met Met Val Leu Ala Ser Leu Glu Gln Leu Gln Ile Arg 1585 1590 1595 gcc ctc ttc tca cag atc tcc tcg gct gtc tcc ctg cgc agg gtg gca 4847 Ala Leu Phe Ser Gln Ile Ser Ser Ala Val Ser Leu Arg Arg Val Ala 1600 1605 1610 1615 ctg gag gtg gcc agc cca gca ggc cag ggg gcc ctg gcc agc aat gtg 4895 Leu Glu Val Ala Ser Pro Ala Gly Gln Gly Ala Leu Ala Ser Asn Val 1620 1625 1630 gag ctg tgc ctg tgc ccc gcc agc tac cgg ggg gac tca tgc cag gaa 4943 Glu Leu Cys Leu Cys Pro Ala Ser Tyr Arg Gly Asp Ser Cys Gln Glu 1635 1640 1645 tgt gcc ccc ggc ttc tat cgg gac gtc aaa ggt ctc ttc ctg ggc cga 4991 Cys Ala Pro Gly Phe Tyr Arg Asp Val Lys Gly Leu Phe Leu Gly Arg 1650 1655 1660 tgt gtc cct tgt cag tgc cat gga cac tca gac cgc tgc ctc cct ggc 5039 Cys Val Pro Cys Gln Cys His Gly His Ser Asp Arg Cys Leu Pro Gly 1665 1670 1675 tct ggc gtc tgt gtg gac tgc cag cac aac acc gaa ggg gcc cac tgt 5087 Ser Gly Val Cys Val Asp Cys Gln His Asn Thr Glu Gly Ala His Cys 1680 1685 1690 1695 gag cgc tgc cag gct ggc ttc atg agc agc agg gac gac ccc agc gcc 5135 Glu Arg Cys Gln Ala Gly Phe Met Ser Ser Arg Asp Asp Pro Ser Ala 1700 1705 1710 ccc tgt gtc agc tgc ccc tgc ccc ctc tca gtg cct tcc aac aac ttc 5183 Pro Cys Val Ser Cys Pro Cys Pro Leu Ser Val Pro Ser Asn Asn Phe 1715 1720 1725 gcc gag ggc tgt gtc ctg cga ggc ggc cgc 5213 Ala Glu Gly Cys Val Leu Arg Gly Gly Arg 1730 1735 <210> 4 <211> 5834 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2480)..(5464) <400> 4 tgctgaagga aagagtaaag ataaaggcga tatggaggtg tacatccaac ctggtccata 60 tgtggatcct ttcacgacag tgaccctggg ctggccagac aatgacaagg agttacgctt 120 ccaatggtca tgtgggtctt gctgggctct gtggagcagc tgtgttgaga ggcagctgct 180 tcgcacagac cagagggagc tggtggttcc agcatcctgc ctgccgccgc ctgactctgc 240 tgtcaccctg cgcctggctg ttctgagagg ccaagagctg gagaacaggg cagagcagtg 300 cctctacgtg tctgcgccct gggaactcag gcctcgagtc agctgtgaga ggaactgcag 360 gccagttaat gccagcaaag acattctgct cagggtcacc atgggggagg actctccagt 420 ggctatgttc agctggtatt tggacaacac cccaacagag caggctgagc ccctcccgga 480 tgcctgcaga ctcagaggat tttggccaag gtccttaacc ctcctccaga gcaacacctc 540 cacgttgctg ttgaacagct cgtttctgca gtcccgggga gaggtcatcc gaatcagagc 600 cacagcactg accaggcatg cctatgggga ggacacctat gtgatcagca ctgtgcctcc 660 ccgtgaggtg cctgcctgca ctattgcccc agaggagggc accgttctga cgagctttgc 720 catcttctgc aacgcctcca cagccctggg acccctggag ttctgcttct gtctggaatc 780 aggttcctgc ctacactgtg gccctgaacc tgccctccca tcagtgtatc tgccacttgg 840 agaggagaac aatgactttg tgctgacagt agttatttct gccaccaatc gtgcagggga 900 cacgcagcag acccaggcca tggctaaggt ggtactcgga gacacatgtg ttgaggatgt 960 agcattccag gctgccgtgt cagagaaaat ccccacagct ctgcaaggcg agggtggccc 1020 cgagcagctc ctccagctgg ccaaggctgt gtcctccatg ctgaaccaag agcatgaaag 1080 ccagggctca ggacagtcac tgagcataga cgtcagacag aaggtcagag agcatgtgct 1140 gggatcactg tctgcagtca ccaccggctt ggaggacgtg cagagggtgc aggagctggc 1200 cgaggtgctg agagaggtga cctgccggag taaggaactc acaccctcgg cccagtggga 1260 ggccagcttg gctctacagc atgccagtga ggccctgttg acagtgagtg ccaaggcccg 1320 ccctgaggac cagaggcgcc aggcagccac cagggacctg tttcaggctg tgggcagtgt 1380 gctggaagct tccctgagca acagaccaga agagcctgcg gaggccagca gcagccagat 1440 tgccacagtg ccacggctgc tttgagtcgt ggagcatgtg cagaccgccc tcctgctggg 1500 aaaactgcca gggggccttc cagccatgct ggccaccccc tccatctctg tgtacacaaa 1560 caggtacaaa ccagctgtgt tacaggtccc caagaaagct catcccctaa cctggttcat 1620 tccacaccgg cactccaaag ccctgtgcta ggcagagctc aggagaccag ccttggagct 1680 agagaagtga tgggacctag agctgggaag ggcttcccac cgagagaagg cccccttgtc 1740 accatgttga gtgtttgcac agcacaggaa gggaggcatg gagtgccaag cccagtgtta 1800 gatccacctg aaggagtcct gagagacggt cacatggcag ctgtgcaggt aagggggctg 1860 aatgaatggg actagcctgc tgttaaccat gctgtgcatg tgtctgacca gccactgctc 1920 cttgggcctg cagggactca agatcctctt acttttggcg tgcgcgcgca cacacaaaca 1980 cacacacaca cagagggctc atctctcagt gagcactgat gccatacctg ggatgctcca 2040 caccttccat tcctccacct gacaagcagg agctggacaa tgctgctggc aacactggga 2100 ccctctgccc caagcctcag ttcctcctgc cagggtttcc ctcttagatc tcacagacag 2160 tttcccaaag cagtatcctg attagaggaa cgatctgaag tggggtcccc aacaagatca 2220 gaaaggggca aggtcaaaga ccagaaaaga tggggcgggg ttaagacatg acgtcagagg 2280 tccaggtggg aaggggagat aaccctggag aaaaacctgc atccaagctc atttattcat 2340 tcaacgaaaa tactgatgga ctacctgtta tatgccaggc gctgctgtag acattggggg 2400 tacagtagta aaccaggctg gcaaagcccc accctcatgg agcctccagt ctagctgcct 2460 cttgtgctgc ttctgctga aac aaa cat gct gaa cca cct atg gga atc aaa 2512 Asn Lys His Ala Glu Pro Pro Met Gly Ile Lys 1 5 10 aca cac ccc cac tct gat ggt gaa gct ggg ctc cca gta gtg cag gag 2560 Thr His Pro His Ser Asp Gly Glu Ala Gly Leu Pro Val Val Gln Glu 15 20 25 gtg tgg ggg ctc cct cga aca ctg act ttc tcc tcc ctc ccc tgc cac 2608 Val Trp Gly Leu Pro Arg Thr Leu Thr Phe Ser Ser Leu Pro Cys His 30 35 40 ctc tgt cct cac ctt gtg gcc aga ata caa ccc tgg agt tgg caa ggc 2656 Leu Cys Pro His Leu Val Ala Arg Ile Gln Pro Trp Ser Trp Gln Gly 45 50 55 tcc tcc ctg cgc cct gat gcc gca gac tct gca acc ttc atg ctg ccc 2704 Ser Ser Leu Arg Pro Asp Ala Ala Asp Ser Ala Thr Phe Met Leu Pro 60 65 70 75 gct gcc tcc tcc ctc agc tct ctg gag ggc ggc cag gag ccc gtg gat 2752 Ala Ala Ser Ser Leu Ser Ser Leu Glu Gly Gly Gln Glu Pro Val Asp 80 85 90 ata aag atc atg agt ttc cca aag agc ccc ttt cca gcc cga agc cac 2800 Ile Lys Ile Met Ser Phe Pro Lys Ser Pro Phe Pro Ala Arg Ser His 95 100 105 ttt gat gtc agc ggg act gtc ggt ggc ctc cgt gtg acc agc cct agt 2848 Phe Asp Val Ser Gly Thr Val Gly Gly Leu Arg Val Thr Ser Pro Ser 110 115 120 ggt caa ctc ata cct gtg aag aat ctg tcg gag aat atc gag atc ctg 2896 Gly Gln Leu Ile Pro Val Lys Asn Leu Ser Glu Asn Ile Glu Ile Leu 125 130 135 ctg ccc cgg cat tca caa aga cac agc cag ccg acc gtg ttg aac ctg 2944 Leu Pro Arg His Ser Gln Arg His Ser Gln Pro Thr Val Leu Asn Leu 140 145 150 155 acc agt cct gaa gct ttg tgg gtg aac gtg act tca ggg gag gca acc 2992 Thr Ser Pro Glu Ala Leu Trp Val Asn Val Thr Ser Gly Glu Ala Thr 160 165 170 ttg ggg atc cag ctg cac tgg aga ccg gac att gca ctc acg ctt agc 3040 Leu Gly Ile Gln Leu His Trp Arg Pro Asp Ile Ala Leu Thr Leu Ser 175 180 185 ctg ggc tat ggc tac cac ccc aac aag agc agc tac gat gcc caa act 3088 Leu Gly Tyr Gly Tyr His Pro Asn Lys Ser Ser Tyr Asp Ala Gln Thr 190 195 200 cac ctc gta cca atg gtg gct cca gat gag ctg ccc acg tgg atc ctg 3136 His Leu Val Pro Met Val Ala Pro Asp Glu Leu Pro Thr Trp Ile Leu 205 210 215 agc cca cag gac ctg cgt ttt gga gaa ggg gtc tac tat ttg act gtg 3184 Ser Pro Gln Asp Leu Arg Phe Gly Glu Gly Val Tyr Tyr Leu Thr Val 220 225 230 235 gtc cct gag tct gac ctg gag cca gcc ccc ggc agg gac ctc acg gtt 3232 Val Pro Glu Ser Asp Leu Glu Pro Ala Pro Gly Arg Asp Leu Thr Val 240 245 250 ggc atc acc acc ttc ctg tct cac tgt gtg ttc tgg gat gag gtc cag 3280 Gly Ile Thr Thr Phe Leu Ser His Cys Val Phe Trp Asp Glu Val Gln 255 260 265 gag act tgg gac gac tca gga tgc cag gtg ggg cct cgg acc agc ccc 3328 Glu Thr Trp Asp Asp Ser Gly Cys Gln Val Gly Pro Arg Thr Ser Pro 270 275 280 tac cag aca cac tgc ctc tgc aac cac ctc act ttc ttc gga agc acg 3376 Tyr Gln Thr His Cys Leu Cys Asn His Leu Thr Phe Phe Gly Ser Thr 285 290 295 ttc ctg gtg atg ccc aat gcc atc gac gtc cac cag act gct gag ctc 3424 Phe Leu Val Met Pro Asn Ala Ile Asp Val His Gln Thr Ala Glu Leu 300 305 310 315 ttt gcc acc ttt gag gac aac cct gtg gtc gtg acc acc gtg ggc tgc 3472 Phe Ala Thr Phe Glu Asp Asn Pro Val Val Val Thr Thr Val Gly Cys 320 325 330 ctg tgt gtg gtc tac gtg ctg gtg gtg atc tgg gcg agg agg aag gac 3520 Leu Cys Val Val Tyr Val Leu Val Val Ile Trp Ala Arg Arg Lys Asp 335 340 345 gct cag gat cag gcc aag gtg aag gtc aca gtg ctg gaa gac aat gat 3568 Ala Gln Asp Gln Ala Lys Val Lys Val Thr Val Leu Glu Asp Asn Asp 350 355 360 ccc ttt gct cag tac cac tac ctg gtg aca gtc tac aca gga cac cga 3616 Pro Phe Ala Gln Tyr His Tyr Leu Val Thr Val Tyr Thr Gly His Arg 365 370 375 cga ggg gca gcc acg tcc tca aag gtg act gtc acc ctg tat ggc ctg 3664 Arg Gly Ala Ala Thr Ser Ser Lys Val Thr Val Thr Leu Tyr Gly Leu 380 385 390 395 gat gga gag aga gag ccc cac cac ctg gct gat cct gac act ccg gtt 3712 Asp Gly Glu Arg Glu Pro His His Leu Ala Asp Pro Asp Thr Pro Val 400 405 410 ttt gag cga gga gca gtg gat gcc ttc ctc ctc tcc acc ctg ttc ccc 3760 Phe Glu Arg Gly Ala Val Asp Ala Phe Leu Leu Ser Thr Leu Phe Pro 415 420 425 ctg gga gaa ctg cgg agc ctc cgg ctg tgg cat gac aac tca ggg gac 3808 Leu Gly Glu Leu Arg Ser Leu Arg Leu Trp His Asp Asn Ser Gly Asp 430 435 440 cgg cca tcg tgg tat gtg agc cgg gtg ctg gtc tat gac ctg gtg atg 3856 Arg Pro Ser Trp Tyr Val Ser Arg Val Leu Val Tyr Asp Leu Val Met 445 450 455 gac cgg aag tgg tat ttc ctg tgc aac tcc tgg cta tcc atc aat gtt 3904 Asp Arg Lys Trp Tyr Phe Leu Cys Asn Ser Trp Leu Ser Ile Asn Val 460 465 470 475 gga gat tgc gtc ctc gac aag gtg ttt cct gtg gcc acg gag cag gac 3952 Gly Asp Cys Val Leu Asp Lys Val Phe Pro Val Ala Thr Glu Gln Asp 480 485 490 aga aaa caa ttc agc cac ctg ttt ttc atg aag act tcc gcg ggc ttc 4000 Arg Lys Gln Phe Ser His Leu Phe Phe Met Lys Thr Ser Ala Gly Phe 495 500 505 cag gat gga cac atc tgg tat tcg atc ttc agc cgc tgc gct cgc agc 4048 Gln Asp Gly His Ile Trp Tyr Ser Ile Phe Ser Arg Cys Ala Arg Ser 510 515 520 agc ttc acc cgc gtc cag agg gtg tcc tgc tgc ttc tcc ctg ctg ctg 4096 Ser Phe Thr Arg Val Gln Arg Val Ser Cys Cys Phe Ser Leu Leu Leu 525 530 535 tgc acc atg ctg acc agc atc atg ttc tgg ggg gtc ccc aag gac cca 4144 Cys Thr Met Leu Thr Ser Ile Met Phe Trp Gly Val Pro Lys Asp Pro 540 545 550 555 gct gag caa aag atg gac ttg ggt aaa att gaa ttc acc tgg cag gag 4192 Ala Glu Gln Lys Met Asp Leu Gly Lys Ile Glu Phe Thr Trp Gln Glu 560 565 570 gtg atg att ggc ctg gag agc tcc atc ctc atg ttc ccc atc aac ctc 4240 Val Met Ile Gly Leu Glu Ser Ser Ile Leu Met Phe Pro Ile Asn Leu 575 580 585 ctg att gtt cag atc ttt cag aac acc cgt ccc cgg gtc gcg aag gag 4288 Leu Ile Val Gln Ile Phe Gln Asn Thr Arg Pro Arg Val Ala Lys Glu 590 595 600 cag aac act gga aaa tgg gac cgg ggg tcc ccc aac ctg act ccc tcc 4336 Gln Asn Thr Gly Lys Trp Asp Arg Gly Ser Pro Asn Leu Thr Pro Ser 605 610 615 cca cag ccc atg gag gac ggc ctt ctg aca cct gag gca gtg acc aag 4384 Pro Gln Pro Met Glu Asp Gly Leu Leu Thr Pro Glu Ala Val Thr Lys 620 625 630 635 gat gtg tca aga atc gtc agc tcc ctc ttc aaa gct ctc aag gtg cca 4432 Asp Val Ser Arg Ile Val Ser Ser Leu Phe Lys Ala Leu Lys Val Pro 640 645 650 tcc ccc gcc ttg ggc tgg gac tca gtg aac ttg atg gac atc aac agt 4480 Ser Pro Ala Leu Gly Trp Asp Ser Val Asn Leu Met Asp Ile Asn Ser 655 660 665 ctc ctc gcc ttg gtg gaa gat gtc att tat cca cag aac aca tca ggg 4528 Leu Leu Ala Leu Val Glu Asp Val Ile Tyr Pro Gln Asn Thr Ser Gly 670 675 680 cag gtg ttc tgg gag gaa gcc aaa aag aga gag gac cct gta aca ctc 4576 Gln Val Phe Trp Glu Glu Ala Lys Lys Arg Glu Asp Pro Val Thr Leu 685 690 695 act ttg ggg tca tca gaa atg aaa gag aaa tca cag tgt ccc aag ccc 4624 Thr Leu Gly Ser Ser Glu Met Lys Glu Lys Ser Gln Cys Pro Lys Pro 700 705 710 715 aag gcg gca cgg agt ggc ccc tgg aag gac agc gcc tac agg cag tgt 4672 Lys Ala Ala Arg Ser Gly Pro Trp Lys Asp Ser Ala Tyr Arg Gln Cys 720 725 730 ctg tac ctt cag ctg gaa cac gtg gag caa gag ctg cgg ctg gtg ggg 4720 Leu Tyr Leu Gln Leu Glu His Val Glu Gln Glu Leu Arg Leu Val Gly 735 740 745 ccc cga ggc ttc ccc cag cac cac agc cat gcc cag gcc ctc agg cag 4768 Pro Arg Gly Phe Pro Gln His His Ser His Ala Gln Ala Leu Arg Gln 750 755 760 ctg cag acc ctg aag ggc ggc ctg ggg gta cag ccg ggc acc tgg gcc 4816 Leu Gln Thr Leu Lys Gly Gly Leu Gly Val Gln Pro Gly Thr Trp Ala 765 770 775 cct gca cat gcc agc gct ctt cag gtg agc aaa ccc cct caa ggc ctg 4864 Pro Ala His Ala Ser Ala Leu Gln Val Ser Lys Pro Pro Gln Gly Leu 780 785 790 795 ccc tgg tgg tgc atc ctg gtg ggc tgg ctc ctg gta gcg gcc acc agt 4912 Pro Trp Trp Cys Ile Leu Val Gly Trp Leu Leu Val Ala Ala Thr Ser 800 805 810 ggg gtg gcg gcc ttc ttc acc atg ctc tac ggc ctg cac tac ggg agg 4960 Gly Val Ala Ala Phe Phe Thr Met Leu Tyr Gly Leu His Tyr Gly Arg 815 820 825 gcc agc tcc ctc agg tgg ctc atc tcc atg gct gtc tcc ttc gtg gag 5008 Ala Ser Ser Leu Arg Trp Leu Ile Ser Met Ala Val Ser Phe Val Glu 830 835 840 agc gtg ttc gtc acc cag ccc ctg aag gtg ctg gga ttc gct gct ttc 5056 Ser Val Phe Val Thr Gln Pro Leu Lys Val Leu Gly Phe Ala Ala Phe 845 850 855 ttt gca ctg gtc ttg aag aga gtg gac gat gag gag gat act gtg gcc 5104 Phe Ala Leu Val Leu Lys Arg Val Asp Asp Glu Glu Asp Thr Val Ala 860 865 870 875 ccg ctg cca gga cat ctg ttg ggc cca gac ccc tat gcc ttg ttc cga 5152 Pro Leu Pro Gly His Leu Leu Gly Pro Asp Pro Tyr Ala Leu Phe Arg 880 885 890 gca cga aga aac agc agc agg gat gtc tac cag cca cct ctc acc gct 5200 Ala Arg Arg Asn Ser Ser Arg Asp Val Tyr Gln Pro Pro Leu Thr Ala 895 900 905 gcc att gag aag atg aaa acc acc cac ctc aag gaa cag aaa gca ttt 5248 Ala Ile Glu Lys Met Lys Thr Thr His Leu Lys Glu Gln Lys Ala Phe 910 915 920 gcc ctc atc aga gaa atc ctg gca tac ttg ggc ttc ctg tgg atg cta 5296 Ala Leu Ile Arg Glu Ile Leu Ala Tyr Leu Gly Phe Leu Trp Met Leu 925 930 935 ctg ctc gtg gcc tac ggg cag agg gac ccc agc gcc tac cac ctc aac 5344 Leu Leu Val Ala Tyr Gly Gln Arg Asp Pro Ser Ala Tyr His Leu Asn 940 945 950 955 aga cac ctc cag cac agc ttc acc agg ggc ttt tca ggt gtg ctc ggc 5392 Arg His Leu Gln His Ser Phe Thr Arg Gly Phe Ser Gly Val Leu Gly 960 965 970 ttc cga gag ttc ttc aag tgg gcc aac acc acc ctc gtg agt aac ctg 5440 Phe Arg Glu Phe Phe Lys Trp Ala Asn Thr Thr Leu Val Ser Asn Leu 975 980 985 tat ggt cac ccc cca ggt aag tcc tgaagccctg gggctgtgtc agcctccttg 5494 Tyr Gly His Pro Pro Gly Lys Ser 990 995 tgccttctgg ctaggaacag acgtggggca ctgtcagcat cagcctcata agaaaaccag 5554 gccaagtgtg gtggcttaca cctgtaatcc tagtactttg ggaggctgag gcgggaggat 5614 tgcttgaggc caggaattcg agaccagcct ggcaacatgg caagaccctg cctctttgaa 5674 aaatacaaaa attagctgga tgtgatgcct catgcctata gtccctgcaa ctctggaggc 5734 tgaggtggga ggattgctta agcccgggag gcagaacctg cagtgagcca aaattgcacc 5794 actgcactcc agcctgggag acagagcaag actctgtctt 5834 <210> 5 <211> 4247 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(3528) <400> 5 ggc cgc aga ggc tgc tcg gcc ccg ctg ccc gcc agg tcg tgg gct ccc 48 Gly Arg Arg Gly Cys Ser Ala Pro Leu Pro Ala Arg Ser Trp Ala Pro 1 5 10 15 gct ccg ggc ccg ggg cca ccg gct gtg gac ttc aaa atg agc gtc cct 96 Ala Pro Gly Pro Gly Pro Pro Ala Val Asp Phe Lys Met Ser Val Pro 20 25 30 gac tac atg cag tgt gct gag gac cac cag acg ctg ctc gtg gtg gtc 144 Asp Tyr Met Gln Cys Ala Glu Asp His Gln Thr Leu Leu Val Val Val 35 40 45 cag cct gtg ggc atc gtc tcc gag gag aac ttc ttc agg atc tat aag 192 Gln Pro Val Gly Ile Val Ser Glu Glu Asn Phe Phe Arg Ile Tyr Lys 50 55 60 agg att tgc tct gtg agt cag atc agc gtg cgg gac tcc cag cga gtc 240 Arg Ile Cys Ser Val Ser Gln Ile Ser Val Arg Asp Ser Gln Arg Val 65 70 75 80 ctc tac atc cgc tac agg cac cac tac cca ccc gag aac aac gag tgg 288 Leu Tyr Ile Arg Tyr Arg His His Tyr Pro Pro Glu Asn Asn Glu Trp 85 90 95 ggc gac ttc cag acc cac cgc aaa gtc gtg ggc ctc atc acc atc aca 336 Gly Asp Phe Gln Thr His Arg Lys Val Val Gly Leu Ile Thr Ile Thr 100 105 110 gac tgc ttc tcg gcc aag gac tgg cca cag acc ttc gag aag ttc cac 384 Asp Cys Phe Ser Ala Lys Asp Trp Pro Gln Thr Phe Glu Lys Phe His 115 120 125 gtg cag aag gag atc tac ggc tcc aca ctg tat gac tcc cgg ctc ttt 432 Val Gln Lys Glu Ile Tyr Gly Ser Thr Leu Tyr Asp Ser Arg Leu Phe 130 135 140 gtc ttc ggg ctg cag ggg gag atc gtg gag cag ccg cgc acc gac gtg 480 Val Phe Gly Leu Gln Gly Glu Ile Val Glu Gln Pro Arg Thr Asp Val 145 150 155 160 gct ttc tac ccc aat tac gag gac tgc cag acg gtg gag aag aga atc 528 Ala Phe Tyr Pro Asn Tyr Glu Asp Cys Gln Thr Val Glu Lys Arg Ile 165 170 175 gag gac ttc atc gag tca ctg ttc atc gtg ctg gag tcc aag cgt ctg 576 Glu Asp Phe Ile Glu Ser Leu Phe Ile Val Leu Glu Ser Lys Arg Leu 180 185 190 gac aga gcc aca gac aag tct ggg gat aag atc ccc ctt ctc tgt gtc 624 Asp Arg Ala Thr Asp Lys Ser Gly Asp Lys Ile Pro Leu Leu Cys Val 195 200 205 ccg ttt gag aaa aag gac ttt gta gga ctg gac aca gac agc aga cat 672 Pro Phe Glu Lys Lys Asp Phe Val Gly Leu Asp Thr Asp Ser Arg His 210 215 220 tac aag aag cgg tgc caa ggc cgc atg cgg aag cac gtg ggg gac ctg 720 Tyr Lys Lys Arg Cys Gln Gly Arg Met Arg Lys His Val Gly Asp Leu 225 230 235 240 tgc ctg cag gca ggg atg ctg cag gac tcc ctg gtg cat tac cac atg 768 Cys Leu Gln Ala Gly Met Leu Gln Asp Ser Leu Val His Tyr His Met 245 250 255 tcg gtg gag ctg ctg cgt tct gtg aat gac ttt ctg tgg ctt gga gct 816 Ser Val Glu Leu Leu Arg Ser Val Asn Asp Phe Leu Trp Leu Gly Ala 260 265 270 gcc ctg gaa gga ttg tgt tca gct tct gtc atc tat cac tat cct ggt 864 Ala Leu Glu Gly Leu Cys Ser Ala Ser Val Ile Tyr His Tyr Pro Gly 275 280 285 gga act ggt ggg aag agt gga gct cgg agg ttc cag ggc agc acc ctt 912 Gly Thr Gly Gly Lys Ser Gly Ala Arg Arg Phe Gln Gly Ser Thr Leu 290 295 300 cct gct gaa gca gcc aat aga cac cgg cca ggg gca cag gaa gtt ctc 960 Pro Ala Glu Ala Ala Asn Arg His Arg Pro Gly Ala Gln Glu Val Leu 305 310 315 320 att gat cca ggt gcc ctc acc acc aat ggc atc aac cct gac acc agt 1008 Ile Asp Pro Gly Ala Leu Thr Thr Asn Gly Ile Asn Pro Asp Thr Ser 325 330 335 act gag atc gga cgt gct aag aac tgc ctt agc cct gaa gac ata att 1056 Thr Glu Ile Gly Arg Ala Lys Asn Cys Leu Ser Pro Glu Asp Ile Ile 340 345 350 gac aag tat aaa gag gcg att tcc tat tac agc aag tat aag aat gcg 1104 Asp Lys Tyr Lys Glu Ala Ile Ser Tyr Tyr Ser Lys Tyr Lys Asn Ala 355 360 365 gga gtg att gag tta gaa gcg tgc atc aag gct gta cgt gtc ctt gca 1152 Gly Val Ile Glu Leu Glu Ala Cys Ile Lys Ala Val Arg Val Leu Ala 370 375 380 att cag aaa cgg agc atg gaa gca tca gaa ttt ctt cag aat gca gtt 1200 Ile Gln Lys Arg Ser Met Glu Ala Ser Glu Phe Leu Gln Asn Ala Val 385 390 395 400 tac att aac ctt cga cag ctt tct gag gaa gag aaa att cag cgc tac 1248 Tyr Ile Asn Leu Arg Gln Leu Ser Glu Glu Glu Lys Ile Gln Arg Tyr 405 410 415 agc atc ctc tcc gag ctc tat gag ctg atc ggc ttc cat cgc aag tct 1296 Ser Ile Leu Ser Glu Leu Tyr Glu Leu Ile Gly Phe His Arg Lys Ser 420 425 430 gcg ttc ttc aag cgc gtg gcc gcc atg cag tgc gtg gcc cca agc atc 1344 Ala Phe Phe Lys Arg Val Ala Ala Met Gln Cys Val Ala Pro Ser Ile 435 440 445 gcg gag cct ggg tgg agg gcc tgc tac aaa ctc ctc ctg gaa acg ctg 1392 Ala Glu Pro Gly Trp Arg Ala Cys Tyr Lys Leu Leu Leu Glu Thr Leu 450 455 460 ccc ggc tac agt ctg tcg ctg gat ccc aaa gat ttc agc aga ggc acg 1440 Pro Gly Tyr Ser Leu Ser Leu Asp Pro Lys Asp Phe Ser Arg Gly Thr 465 470 475 480 cac aga ggc tgg gct gcg gtc cag atg cgt ttg ctc cat gaa ttg gtc 1488 His Arg Gly Trp Ala Ala Val Gln Met Arg Leu Leu His Glu Leu Val 485 490 495 tac gcc tcc cga agg atg ggg aac cct gcc ctc tct gtc aga cac ctg 1536 Tyr Ala Ser Arg Arg Met Gly Asn Pro Ala Leu Ser Val Arg His Leu 500 505 510 tcc ttc ctt cta cag acc atg ctg gac ttc ttg tcg gat cag gaa aag 1584 Ser Phe Leu Leu Gln Thr Met Leu Asp Phe Leu Ser Asp Gln Glu Lys 515 520 525 aaa gat gtg gcc caa agc cta gag aac tat acg tcc aag tgt cct ggg 1632 Lys Asp Val Ala Gln Ser Leu Glu Asn Tyr Thr Ser Lys Cys Pro Gly 530 535 540 acc atg gag ccc atc gcc ctc cct ggc ggc ctc acc ctg cca ccg gtg 1680 Thr Met Glu Pro Ile Ala Leu Pro Gly Gly Leu Thr Leu Pro Pro Val 545 550 555 560 ccc ttc acc aag ctt ccc atc gtc agg cat gtg aaa cta ttg aac ctt 1728 Pro Phe Thr Lys Leu Pro Ile Val Arg His Val Lys Leu Leu Asn Leu 565 570 575 cct gct agc ctc cgg cca cac aaa atg aaa agc ttg ctg ggt cag aac 1776 Pro Ala Ser Leu Arg Pro His Lys Met Lys Ser Leu Leu Gly Gln Asn 580 585 590 gtg tca acc aaa agt cct ttc atc tat tca cca att atc gca cac aac 1824 Val Ser Thr Lys Ser Pro Phe Ile Tyr Ser Pro Ile Ile Ala His Asn 595 600 605 cgt gga gaa gag cgg aac aag aaa ata gat ttc cag tgg gtt caa gga 1872 Arg Gly Glu Glu Arg Asn Lys Lys Ile Asp Phe Gln Trp Val Gln Gly 610 615 620 gat gtg tgt gaa gtt cag ctg atg gta tat aac cca atg ccg ttt gaa 1920 Asp Val Cys Glu Val Gln Leu Met Val Tyr Asn Pro Met Pro Phe Glu 625 630 635 640 ctt cga gtt gaa aac atg ggg ctg ctc acc agc gga gtg gag ttc gag 1968 Leu Arg Val Glu Asn Met Gly Leu Leu Thr Ser Gly Val Glu Phe Glu 645 650 655 tct ctc cct gcg gcg ctt tct ctt ccg gct gaa tct ggt ctg tac cca 2016 Ser Leu Pro Ala Ala Leu Ser Leu Pro Ala Glu Ser Gly Leu Tyr Pro 660 665 670 gtg acg ctc gtc ggg gtc ccg cag acg act gga acg att act gtg aac 2064 Val Thr Leu Val Gly Val Pro Gln Thr Thr Gly Thr Ile Thr Val Asn 675 680 685 ggt tac cat acc acg gtc ttc ggt gtg ttc agt gac tgt ttg ctg gat 2112 Gly Tyr His Thr Thr Val Phe Gly Val Phe Ser Asp Cys Leu Leu Asp 690 695 700 aac ctg ccg gga ata aaa acc agt ggc tcc aca gtg gaa gtc att ccc 2160 Asn Leu Pro Gly Ile Lys Thr Ser Gly Ser Thr Val Glu Val Ile Pro 705 710 715 720 gcg ttg cca aga ctg cag atc agc acc tct ctg ccc aga tct gca cat 2208 Ala Leu Pro Arg Leu Gln Ile Ser Thr Ser Leu Pro Arg Ser Ala His 725 730 735 tca ttg caa cct tct tct ggt gat gaa ata tct act aat gta tct gtc 2256 Ser Leu Gln Pro Ser Ser Gly Asp Glu Ile Ser Thr Asn Val Ser Val 740 745 750 cag ctt tac aat gga gaa agt cag caa cta atc att aaa ttg gaa aat 2304 Gln Leu Tyr Asn Gly Glu Ser Gln Gln Leu Ile Ile Lys Leu Glu Asn 755 760 765 att gga atg gaa cca ttg gag aaa ctg gag gtc acc tcg aaa gtt ctc 2352 Ile Gly Met Glu Pro Leu Glu Lys Leu Glu Val Thr Ser Lys Val Leu 770 775 780 acc act aaa gaa aaa ttg tat ggc gac ttc ttg agc tgg aag cta gag 2400 Thr Thr Lys Glu Lys Leu Tyr Gly Asp Phe Leu Ser Trp Lys Leu Glu 785 790 795 800 gaa acc ctt gcc cag ttc cct ttg cag cct ggg aag gtg gcc acg ttc 2448 Glu Thr Leu Ala Gln Phe Pro Leu Gln Pro Gly Lys Val Ala Thr Phe 805 810 815 aca atc aac atc aaa gtg aag ctg gat ttc tcc tgc cag gag aat ctc 2496 Thr Ile Asn Ile Lys Val Lys Leu Asp Phe Ser Cys Gln Glu Asn Leu 820 825 830 ctg cag gat ctc agt gat gat gga atc agt gtg agt ggc ttt ccc ctg 2544 Leu Gln Asp Leu Ser Asp Asp Gly Ile Ser Val Ser Gly Phe Pro Leu 835 840 845 tcc agt cct ttt cgg cag gtc gtt cgg ccc cga gtg gag ggc aaa cct 2592 Ser Ser Pro Phe Arg Gln Val Val Arg Pro Arg Val Glu Gly Lys Pro 850 855 860 gtg aac cca ccc gag agc aac aaa gca ggc gac tac agc cac gtg aag 2640 Val Asn Pro Pro Glu Ser Asn Lys Ala Gly Asp Tyr Ser His Val Lys 865 870 875 880 acc ctg gaa gct gtc ctg aat ttc aaa tac tct gga ggc ccg ggc cac 2688 Thr Leu Glu Ala Val Leu Asn Phe Lys Tyr Ser Gly Gly Pro Gly His 885 890 895 act gaa gga tat tac agg aat ctc tcc ctg ggg ctg cat gta gaa gtc 2736 Thr Glu Gly Tyr Tyr Arg Asn Leu Ser Leu Gly Leu His Val Glu Val 900 905 910 gag ccg tct gta ttt ttc acc cga gtc agc acc ctc cca gca acc agt 2784 Glu Pro Ser Val Phe Phe Thr Arg Val Ser Thr Leu Pro Ala Thr Ser 915 920 925 acc cgg cag tgt cac ctg ctc ctg gat gtc ttc aac tcc acc gag cat 2832 Thr Arg Gln Cys His Leu Leu Leu Asp Val Phe Asn Ser Thr Glu His 930 935 940 gag ctg acc gtc agc acc agg agc agc gag gca ctc atc ctg cac gcc 2880 Glu Leu Thr Val Ser Thr Arg Ser Ser Glu Ala Leu Ile Leu His Ala 945 950 955 960 ggc gag tgc cag cga atg gct att caa gtg gac aag ttc aac ttt gag 2928 Gly Glu Cys Gln Arg Met Ala Ile Gln Val Asp Lys Phe Asn Phe Glu 965 970 975 agt ttc ccg gag tcc cct ggg gag aag ggg caa ttt gca aac ccc aag 2976 Ser Phe Pro Glu Ser Pro Gly Glu Lys Gly Gln Phe Ala Asn Pro Lys 980 985 990 cag ctg gag gaa gag cgg cgg gaa gcc cga ggc ctg gag atc cac agc 3024 Gln Leu Glu Glu Glu Arg Arg Glu Ala Arg Gly Leu Glu Ile His Ser 995 1000 1005 aag ctg ggc atc tgc tgg aga atc ccc tcc ctg aag cgc agt ggc gag 3072 Lys Leu Gly Ile Cys Trp Arg Ile Pro Ser Leu Lys Arg Ser Gly Glu 1010 1015 1020 gcg agt gtg gaa gga ctc ctg aac cag ctc gtc ctg gag cac ctg cag 3120 Ala Ser Val Glu Gly Leu Leu Asn Gln Leu Val Leu Glu His Leu Gln 1025 1030 1035 1040 ctg gcg cct ctg cag tgg gat gtg ctg gtg gac gga cag cca tgt gac 3168 Leu Ala Pro Leu Gln Trp Asp Val Leu Val Asp Gly Gln Pro Cys Asp 1045 1050 1055 cgc gag gct gtg gcg gcc tgc cag gtg ggc gac ccc gtg cgc ctg gag 3216 Arg Glu Ala Val Ala Ala Cys Gln Val Gly Asp Pro Val Arg Leu Glu 1060 1065 1070 gtg cgg ctg acc aac cgg agc ccg cgc agc gta ggg ccc ttc gcc ctc 3264 Val Arg Leu Thr Asn Arg Ser Pro Arg Ser Val Gly Pro Phe Ala Leu 1075 1080 1085 act gtg gtc ccc ttc cag gac cac cag aac ggc gtg cac aac tac gac 3312 Thr Val Val Pro Phe Gln Asp His Gln Asn Gly Val His Asn Tyr Asp 1090 1095 1100 ctg cac gac acc gtc tcc ttc gtg ggc tcc agc acc ttc tac ctc gac 3360 Leu His Asp Thr Val Ser Phe Val Gly Ser Ser Thr Phe Tyr Leu Asp 1105 1110 1115 1120 gcg gtg cag ccg tcc ggc cag tcg gcc tgc ctc ggg gcc ctc ctc ttc 3408 Ala Val Gln Pro Ser Gly Gln Ser Ala Cys Leu Gly Ala Leu Leu Phe 1125 1130 1135 ctc tac acg gga gac ttc ttc ctc cac atc cgg ttc cac gag gac agc 3456 Leu Tyr Thr Gly Asp Phe Phe Leu His Ile Arg Phe His Glu Asp Ser 1140 1145 1150 acc agc aag gag ctg cca ccc tct tgg ttc tgc ctg ccc agt gtg cac 3504 Thr Ser Lys Glu Leu Pro Pro Ser Trp Phe Cys Leu Pro Ser Val His 1155 1160 1165 gtg tgt gcc ctg gag gcg cag gcc tgagcccgcc tacttccgtc cctctttctg 3558 Val Cys Ala Leu Glu Ala Gln Ala 1170 1175 cagggccaga ggtgaccctg cctggcctcc cacaccccct gcaatgagca aggccttcac 3618 tgcagcccca tctcctcctc ctcccccaga cccctcccag ccctctcctc ctgttcctcc 3678 tgtagcatct ttgctgggct acgcagaagc cccggacatg gcagccccac cccatgccac 3738 gccccttcct acactgttcc ctggaccata cacaggctga agcagaggaa atcccaaagc 3798 gggtgcccat ccagcccagg tcccaggatc cctgcaccca tttctgtgac ctggggcccc 3858 agccgtgctg tgctgctcat cccagcagag ggacctccct cgtccagcga cttccctttg 3918 gccatagaaa gaaatggtga gcatgagact gggcacagcc tgagggcgtg ggcagcttcc 3978 caccctccct gggccttgga atcccccaag gctggttttc ttcctggaga cccccatggg 4038 caacttggca ggagagatgg tgccgtagga ggtcgtggat ggttgatgcc aagagaggcc 4098 ctccacccgt ggtgggcaaa tgtccaggcc tgggctggca gcccagggct gtttctgggt 4158 gctccctggc cccagggtgg cgtctggtta ccatggctgt gtgtgtccat gtctgcaagc 4218 agttcttcaa taaatggcct gcctccccc 4247 <210> 6 <211> 6640 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (361)..(987) <400> 6 cagctgaagc tttcacaagt ttgtacaaaa aagcaggctc ttcctccttg ctgctgctgc 60 cgccgccaat cctggtccgg ttgcccgagt tcccggaggt ctctcgcggg acctctctca 120 ccgccaccgc tcctactctc gggcttccaa atctggggcg atgtctcccc aggttaaatt 180 accctagctc ctgctccaga tcgcttcccc gtgccccgcc agagcccagt agttcaaaaa 240 ttaaatttgg ggcaaggggt gcgcgccaga gcgcagctgt ttctggagcc tgcggcagcg 300 gtggcgagcc acagggcggc gaccgtgagc tccgggagct gcgcaaacca cctggagacc 360 atg tct ggg gat gcg acc agg acc ctg ggg aaa gga agc cag ccc cca 408 Met Ser Gly Asp Ala Thr Arg Thr Leu Gly Lys Gly Ser Gln Pro Pro 1 5 10 15 ggg cca gtc ccg gag ggg ctg atc cgc atc tac agc atg agg ttc tgc 456 Gly Pro Val Pro Glu Gly Leu Ile Arg Ile Tyr Ser Met Arg Phe Cys 20 25 30 ccc tat tct cac agg acc cgc ctc gtc ctc aag gcc aaa gac atc aga 504 Pro Tyr Ser His Arg Thr Arg Leu Val Leu Lys Ala Lys Asp Ile Arg 35 40 45 cat gaa gtg gtc aac att aac ctg aga aac aag cct gaa tgg tac tat 552 His Glu Val Val Asn Ile Asn Leu Arg Asn Lys Pro Glu Trp Tyr Tyr 50 55 60 aca aag cac cct ttt ggc cac att cct gtc ctg gag acc agc caa tgt 600 Thr Lys His Pro Phe Gly His Ile Pro Val Leu Glu Thr Ser Gln Cys 65 70 75 80 caa ctg atc tat gaa tct gtt att gct tgt gag tac ctg gat gat gct 648 Gln Leu Ile Tyr Glu Ser Val Ile Ala Cys Glu Tyr Leu Asp Asp Ala 85 90 95 tat cca gga agg aag ctg ttt cca tat gac cct tat gaa cga gct cgc 696 Tyr Pro Gly Arg Lys Leu Phe Pro Tyr Asp Pro Tyr Glu Arg Ala Arg 100 105 110 caa aag atg tta ttg gag cta ttt tgt aag att ctt gag tat cag aac 744 Gln Lys Met Leu Leu Glu Leu Phe Cys Lys Ile Leu Glu Tyr Gln Asn 115 120 125 acc acc ttc ttt ggt gga acc tgt ata tcc atg att gat tac ctc ctc 792 Thr Thr Phe Phe Gly Gly Thr Cys Ile Ser Met Ile Asp Tyr Leu Leu 130 135 140 tgg ccc tgg ttt gag cgg ctg gat gtg tat ggg ata ctg gac tgt gtg 840 Trp Pro Trp Phe Glu Arg Leu Asp Val Tyr Gly Ile Leu Asp Cys Val 145 150 155 160 agc cac acg cca gcc ctg cgg ctc tgg ata tca gcc atg aag tgg gac 888 Ser His Thr Pro Ala Leu Arg Leu Trp Ile Ser Ala Met Lys Trp Asp 165 170 175 ccc aca gtc tgt gct ctt ctc atg gat aag agc att ttc cag ggc ttc 936 Pro Thr Val Cys Ala Leu Leu Met Asp Lys Ser Ile Phe Gln Gly Phe 180 185 190 ttg aat ctc tat ttt cag aac aac cct aat gcc ttt gac ttt ggg ctg 984 Leu Asn Leu Tyr Phe Gln Asn Asn Pro Asn Ala Phe Asp Phe Gly Leu 195 200 205 tgc tgagtctcac tgtccacccc ttcgctgtcc agaattcccc agcttgttgg 1037 Cys gagtctacgt cacggcttgt cttgggaacc aatccgtctc tctttctttt ctttgaagtt 1097 cccaataaaa tgaaaacagg aaatgtattc ttctgataat catttgtctg actcctctag 1157 cctgtagctg ctgctactgc tgcttttttt tccttttttt ttttgaggca agatcttgct 1217 tcgttactca ggctggagtg cagtgggaca gtcggctcac tgcagccttg aactcctggg 1277 ctcagttgat tctcccgcct cagcctcctg agaagctagg actacaggta tgtgtcacca 1337 cgcccagcta atttttaaaa aaatgttgtt gagacagggt ctcactatgt tgctcaggct 1397 ggtctccatc tcctggccgc aagccatcca cccaacttgg tctccaaagt gttgagatta 1457 caggcatgag ccacctggcc tgcctagcct gtagcttcta actattttct agaaagtgcc 1517 tggtgctaat gtcagagcac attttgggag cctgtgtgcc tcctaactcc ttggccttca 1577 gcctagtttg atctccagat tattggtgca gatgctgatg ctgaggttca gggtcaacct 1637 atgactgatg cttgtcacta cagaatggca ccctccaaag acctccctgg tgaaagctta 1697 agaagaggga gaaggaagaa gaaaacactc caaacctaaa taccttccat ttggcaaatg 1757 aatgtcgctg tccacgtggg cgagtatgag tgtaattctc caaactttgg ccatgggcct 1817 ggagacaccg agggtcttgt gactggaaag aattccaaag caggaaatga aacaccggtt 1877 tatcacccag gactaactac gtcagaattt cactggtgct gtcagggctc aggatgtctc 1937 acaaaatgtt ctatagccgg catcctgcct taaaaaaata cacacgcccc aaacccagcc 1997 acaagcaaag gtcattccgt tggatttgcg tcacactctc ttccaattca tctcaacaaa 2057 tgcctctggt tgcctgttgt gtaccaagcc caggggcaca ctggggataa agttgaaaaa 2117 gacattggct ctgtccctgg gagcccccat ctctccactt atcttggttg aggttttaaa 2177 cctagcgctt tggagctgct tgtctgttgt agggatgctt gtctctgatg tggcccctct 2237 gccagcttcg ccaggcagta ccaccccact gaagacagca aagagctgag gatggctggt 2297 gccaacaggt cccttgggct gggagcatct actgcctgca ctatgggagg gggaccaagt 2357 ttgtccaatg ctgtttcatc tcagtgtctg aggatcagcc tgtgatcatt tcagctttgc 2417 tcatgctgga tcctttccca tcctcctagc tgtgctgaga caccaggcag caacaggagc 2477 gatgttttgc cttgtctgtg ctccctaagg agctgtctgc cacctctgcc tctgagacag 2537 cccaaatcag ccctcctctc tccccacgtc tcagtctggc cctgccatct gctggctctg 2597 ggtatatttt gacccatgta aatagttacc aggtgttact ctgtgccagc tggacagaaa 2657 caagcctgct tggtgaggtg gccagaactt ccagaagagg cagcgcatga caggggcagt 2717 ctgccgcacc atctgctccg gatgtggagc cctgttgcca tggcacccta gttaatgctg 2777 agtgaggtct gtgaatcacc gttttcctgg gatctttgct ccaagaagag gggaatcttc 2837 tcctgtggcc tctcatagga cttaggagat tgatcagcct tttgccggta caaatcctgc 2897 atgctagtga gtgcttgtca taagaccaaa gttaccactg atgcaacagg aaatggcatg 2957 cctctggctc accaaaatga aggtgttctc ttttggggct ccgcacacta atttagaaag 3017 cttgaagaac caggaattat agaatggaga aaagcactca tgggggaggt ttgcagcctg 3077 gtggcctata gcccagtttg ggatttgagt gcctcttggc caggcatgct ccctgctgtt 3137 taccagggtc ctggtcacct gcacatcctt acacttcctc catctcgctt ctttgtcact 3197 tgtctgaccc acagagaaaa ctgagttatc aatctttgaa taaaactaga aggatgtggc 3257 ctggagaaaa gagggaagga ggtaattaaa taatgctcca tgaagaactt taaaaatatg 3317 cttcttaatt aatacatgtg gaaagaatac atatgggtta aaaatacaat aatgtaaaag 3377 aatagaaaat cttccattat cttgtgtcct agagataacc acttttagta attggtgtct 3437 accttttttt ccccttttct tttaaataat agagatgggg tttcgctatg ttgaccaggc 3497 tggtcttgaa ctcctggctt caagtgatcc tcccatctcg gcatcccaaa gtgctgggat 3557 tataggtctg agtcatcatg cctggtgggt gtctatctta taaaaagcac taaacttaaa 3617 gatttaaagg tgagagcctg tattaggcca ttctcatggt gctataaaga actgcccaag 3677 actgagtaat ttataaagga aagaggttta attgactcac aattccacat ggctggggaa 3737 gcctcaggaa actttcaatc atggtggaag gggaagcaaa catgtccttc tgcacaaggt 3797 ggcagaagag agaagtacag agccaaagag ggaaaaactc cttataaaac cattagatct 3857 catgagagct cgctcactgt catgagaaaa gcatagggaa aacactccca caatcgaatc 3917 acctcccttg aggtccctcc cccaacatgt ggggattata attcagatta aaattgaaga 3977 tgagatttta ggtggagcac agccaaacca tatcagagcc attctctatc ttttgcagat 4037 tggaaaaata aaaaaattag tttaaaccac agcatttaaa agaaatggtc atagatgatg 4097 ttaacatcag aatggaggtt gtgtggagtt cccctccttg gaggttctga gctacagcct 4157 agcctggact cagtccagtt acaatctaac atggctaggg ggaggaggga gcatgatggg 4217 gcagggcttg tgtggctggg acagctggct atggtcgtgg tgctggtgac taaatggtac 4277 ttgaaatttc ttttagatct aaaattctgt gatatggttt ggatctgaga ccccaccaaa 4337 tttcgtgttg aaatgtagtc cccaatgctg gtgggaggtg attggatcat gggggtagat 4397 ttctcatgaa tggtttagca ccattctctt ggtgctgttc tcatgatagt gagtgagttc 4457 tcatgagttc tggttgttta aaagtgtgca gcatctccct gacccctctt gcgccagctc 4517 ccaccatggg agatgcctcg ctcccccttt gctttttgcc atgagaggaa gcttcctgag 4577 ggctctccag aagcagaatc tactacactt ctcatacagc ctgcagaacc atgagccaat 4637 taaacctctt tttaaaaaca cttttatttt aagttcaggg gtacatgtgc aggatgtgca 4697 ggttcgttcc ataggtaaac atgcgtcatg gggtttgtta tgcagattat ttcatcacct 4757 agatattaag tctagtatcc attagttatt tttcctgatc ctctccctcc tcccaccctg 4817 caccctctga taggcctcag tgtgtattgt taccctccac atgtccatgt gttctcatga 4877 tttagctccc acttataagt gagaacatgc agtttttgta aacctgtttt ctttagggaa 4937 agtttagaat tttctagaga ctggttgtat ggttgtgacc aaaatgccag tagtgatatg 4997 gacagtgaag gccaggctga ggaggtgatg gaaatgagga acttactggg aactggagca 5057 aaggtcactt ttgttatgct ttagcaaaga acttggctgc attgtgctcc tggcctaggg 5117 acctgtggaa gtttgaactt gagagtgatg attttagggt atctggcaga aaaaatttct 5177 aagcagcaaa gcattcaaga tgcgccctgg ctgctttcaa caacctatgc tcatatttgt 5237 gagcaaagaa attatgttaa gttggaactt atatttacag gggaagcaga gcgtaaaagt 5297 ttggagaatt tgcagccagc tatgtggtag aaaagaagag cccattttca gggaaggaat 5357 tcaagcaggc tgcagaaatt tgcataagta aaaaggagcc aagtgctaat ggccaagaaa 5417 atggggaaaa ggccttgaag gcatttcaga gacctttgtg gcagcccctc ccatcacaga 5477 ctcagaggcc taggaggaca gaatgactct gagtattaaa gtagatttaa tctaaatcat 5537 aaagtacaag ctagagcaat ccctccagtg ctgcagaaac tgcctgcatg tggctcccac 5597 attgtttctt ggagctttgg tggtggtagg ggtggcaggg gcaggtgtta tgtttcttgg 5657 tttctcacct tcaggtctcc ttacccatgt ttcctttgtc agagtcattg gccttgatgg 5717 aggggagact gggttactct gagttgagaa gcaagcttga ctgccctgtg gtttatatca 5777 gcctagctta gtttgttttc tgaagtcttc acaaataacc aaatatccag cccagtgcag 5837 ttctcaatga gtagtctcca gttcccatcc cccaccacac acacacacca aacactgtgc 5897 ccacctggga gacccatttt catttatctt cttctttgag tgcctggaag gctgaacatt 5957 tgatcttttc aaacattttt ctctcatctg gcctgttagc gctcttgagc ctttgaaaat 6017 gccatttcct ctacatacta ttcttcctca gagcagccct ctgttttttt ttccaaccag 6077 tcttttctct tgcaaagttc agatcaaaat tcttctttat gtaaagagaa gtggcgtgcc 6137 ataggggtta caaacagggc ttcaaggtta gcactgggat caaattccga ctttgcaact 6197 taactttctt gagtaagttg ctacacctct attagcctca gtttcttatc tgtaaaatgg 6257 gacggctaag tacctatttc attgggctgt tgaataatga tggtctcatc tatgcaaggg 6317 cttagtacca gctgggtgaa actcagtgaa tggcaggcaa ccctattatg actaggcttc 6377 tgccaatgat cagacttgaa ccctgtgctc atccccccat cactttgtgg aactagatgt 6437 cctacgttgc acatggcttg attcatggtt tggagttgtt ttctggttgt ttcctgtgtg 6497 caggtttaat ctcaacctgt gatcccttga aagctgcaat tttatccctc cctctcaccc 6557 caaggccaag tttaatactg tgcattctga aatcttgcaa tgttgatgat gtaaaataaa 6617 tcttctctcc tgtgtttctg aag 6640 <210> 7 <211> 2145 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(1714) <400> 7 g gca tcc gcc tcc tcg ccc gac gac ggc ggc cgc acc gac cgc ttt gcc 49 Ala Ser Ala Ser Ser Pro Asp Asp Gly Gly Arg Thr Asp Arg Phe Ala 1 5 10 15 ttc cag ctg ccc ttt gct gag ggc gcg ggc gat ggg gcg cgc ctc gac 97 Phe Gln Leu Pro Phe Ala Glu Gly Ala Gly Asp Gly Ala Arg Leu Asp 20 25 30 ttc gtg gtg cgc tat gag acc cct gag ggc act ttc tgg gcc aac aac 145 Phe Val Val Arg Tyr Glu Thr Pro Glu Gly Thr Phe Trp Ala Asn Asn 35 40 45 cac ggc cgc aac tac aca gtc ctg ctc cgg atc gca ccc gct ccc aca 193 His Gly Arg Asn Tyr Thr Val Leu Leu Arg Ile Ala Pro Ala Pro Thr 50 55 60 ccc act gat gcc gaa ggg ctg ccc cag cag cag cag ctg ccg cag ctg 241 Pro Thr Asp Ala Glu Gly Leu Pro Gln Gln Gln Gln Leu Pro Gln Leu 65 70 75 80 gag cca cag ccc gag tgc cag ggt ccc gtg gag gct gag gcc agg cag 289 Glu Pro Gln Pro Glu Cys Gln Gly Pro Val Glu Ala Glu Ala Arg Gln 85 90 95 ctg aag agc tgc atg aag ccg gtg agg cgc agg cct gcc gag gag gaa 337 Leu Lys Ser Cys Met Lys Pro Val Arg Arg Arg Pro Ala Glu Glu Glu 100 105 110 ctg aag acg aag aac atg gat gat aac acc ttt gcc atg gca gag cat 385 Leu Lys Thr Lys Asn Met Asp Asp Asn Thr Phe Ala Met Ala Glu His 115 120 125 cct gat gtc cag gag tca gtg ggt cca ctg gta gcc ccc acc cct ctc 433 Pro Asp Val Gln Glu Ser Val Gly Pro Leu Val Ala Pro Thr Pro Leu 130 135 140 cgt cca tgg ccc cag atg aca ctt cag gtt tct gac gtt ccg atg act 481 Arg Pro Trp Pro Gln Met Thr Leu Gln Val Ser Asp Val Pro Met Thr 145 150 155 160 ggc aac ccc gca gaa gaa ggt gat gtc ccc aga agc agt cca cct gtg 529 Gly Asn Pro Ala Glu Glu Gly Asp Val Pro Arg Ser Ser Pro Pro Val 165 170 175 gct ttt aca gag gtc ctc cag gca ccg gcc atc agg att ccc ccc tcc 577 Ala Phe Thr Glu Val Leu Gln Ala Pro Ala Ile Arg Ile Pro Pro Ser 180 185 190 tcc cct ctc tgt ggc ctg ggt ggc tcc ccc aga gac cag gcc tca ggg 625 Ser Pro Leu Cys Gly Leu Gly Gly Ser Pro Arg Asp Gln Ala Ser Gly 195 200 205 ccc gat gcg agc gag ggg gcc acc ggg cct ttc ctg gag ccc agt cag 673 Pro Asp Ala Ser Glu Gly Ala Thr Gly Pro Phe Leu Glu Pro Ser Gln 210 215 220 cag cag gca gag gcc aca tgg gga gta tcg agt gag aat gga ggg ggg 721 Gln Gln Ala Glu Ala Thr Trp Gly Val Ser Ser Glu Asn Gly Gly Gly 225 230 235 240 ctg gag gct gtg agt ggg tca gag gag ctg ctc ggt gag gac acc atc 769 Leu Glu Ala Val Ser Gly Ser Glu Glu Leu Leu Gly Glu Asp Thr Ile 245 250 255 gac cag gag ctg gag cag ctc tac ctg tct cac ctg agc cgc cta cgg 817 Asp Gln Glu Leu Glu Gln Leu Tyr Leu Ser His Leu Ser Arg Leu Arg 260 265 270 gct gct gtg gct gcg ggt ggg gca ggg ggt ggt ggg gag ggc tcc aca 865 Ala Ala Val Ala Ala Gly Gly Ala Gly Gly Gly Gly Glu Gly Ser Thr 275 280 285 gat gga ggg atg tcc ccc agc cat ccc ctg ggc ata ctg acg gac cgc 913 Asp Gly Gly Met Ser Pro Ser His Pro Leu Gly Ile Leu Thr Asp Arg 290 295 300 gac ctg atc ttg aag tgg cct ggc cct gag cgg gcc ctg aac agc gcc 961 Asp Leu Ile Leu Lys Trp Pro Gly Pro Glu Arg Ala Leu Asn Ser Ala 305 310 315 320 ctg gct gag gag atc acg ctg cac tat gcc cgg ctg ggg cgt ggc gtg 1009 Leu Ala Glu Glu Ile Thr Leu His Tyr Ala Arg Leu Gly Arg Gly Val 325 330 335 gag ctc atc aag gac acc gaa gac cct gat gat gaa ggg gag ggt gaa 1057 Glu Leu Ile Lys Asp Thr Glu Asp Pro Asp Asp Glu Gly Glu Gly Glu 340 345 350 gag ggg ctc tct gtc aca ccc tcc agc cca gaa ggg gac agc ccc aag 1105 Glu Gly Leu Ser Val Thr Pro Ser Ser Pro Glu Gly Asp Ser Pro Lys 355 360 365 gaa tcg cct cca gaa atc ctc tcc ggg gcc cgt tct gtg gta gcc acg 1153 Glu Ser Pro Pro Glu Ile Leu Ser Gly Ala Arg Ser Val Val Ala Thr 370 375 380 atg gga gat gtg tgg ctc cca tgg gca gag ggc tca gga tgt gac ggc 1201 Met Gly Asp Val Trp Leu Pro Trp Ala Glu Gly Ser Gly Cys Asp Gly 385 390 395 400 cct gtg gtt ctg ggt aca gag ggt cag ttc att ggg gat cct gag aaa 1249 Pro Val Val Leu Gly Thr Glu Gly Gln Phe Ile Gly Asp Pro Glu Lys 405 410 415 ggg atg ggc aag gac acc agc tct ttg cac atg aat agg gtg ata gct 1297 Gly Met Gly Lys Asp Thr Ser Ser Leu His Met Asn Arg Val Ile Ala 420 425 430 ggg gtg act gag tcc ctg ggg gag gcc ggg aca gaa gcc cag ata gag 1345 Gly Val Thr Glu Ser Leu Gly Glu Ala Gly Thr Glu Ala Gln Ile Glu 435 440 445 gtc acc agt gag tgg gca ggc agc ttg gat ccc ata tct ggc aag gag 1393 Val Thr Ser Glu Trp Ala Gly Ser Leu Asp Pro Ile Ser Gly Lys Glu 450 455 460 cca gcc tct ccc gtc ctt ctg cag ggg caa aat ccc acc ctc ctc agt 1441 Pro Ala Ser Pro Val Leu Leu Gln Gly Gln Asn Pro Thr Leu Leu Ser 465 470 475 480 ccc ttg ggg gcc gaa gtc tgt ctc tct agt gta gcc agg cct cat gtg 1489 Pro Leu Gly Ala Glu Val Cys Leu Ser Ser Val Ala Arg Pro His Val 485 490 495 agc tcc cag gat gaa aag gat gca ggc cca agc ctt gaa ccc cca aag 1537 Ser Ser Gln Asp Glu Lys Asp Ala Gly Pro Ser Leu Glu Pro Pro Lys 500 505 510 aag tct ccc acc cta gca gtc cct gca gaa tgt gtg tgt gca ctg cct 1585 Lys Ser Pro Thr Leu Ala Val Pro Ala Glu Cys Val Cys Ala Leu Pro 515 520 525 cct cag ctc cgg ggg ccc ttg acc cag act ctg ggg gtc ctg gcc ggg 1633 Pro Gln Leu Arg Gly Pro Leu Thr Gln Thr Leu Gly Val Leu Ala Gly 530 535 540 cta gtg gtg gtc cct gtg gct ctg aac agc ggt gtg tcc ctc ctg gtg 1681 Leu Val Val Val Pro Val Ala Leu Asn Ser Gly Val Ser Leu Leu Val 545 550 555 560 ctt gcg ctg tgc ctc tct ctg gct tgg ttc tca taggctctgc ttgtgggatc 1734 Leu Ala Leu Cys Leu Ser Leu Ala Trp Phe Ser 565 570 agcagaggct taagatggga tacatggcct gtgcagtgag gggacctggg tcctttgctt 1794 ctgagaatgc tcaactgaaa gagaggcctt ctcatcccca agctctccag tcaacacagg 1854 gctccctgtg gtgacaccag tggagatgag ggaacgggta gatggtgtga gtgaggggaa 1914 cttttagagt ggaactgggc atgtcctccg cctacccccc gagcctgtat ttatttttgt 1974 ataattctct ggatgaggga gagtggtcgt gagctggtct tggggcacaa ttacccagag 2034 atatatttat taacagccaa cctgtgcaac ctgctggagc tttattttta atttaattta 2094 tatagagtac ctattattat atgccacaat agagctctat gagaaacagt g 2145 <210> 8 <211> 2347 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(679) <400> 8 c gcg gcg acg ggg cgc ggc ggg ctc cct cgg ggt ccc agc tgg ccg gca 49 Ala Ala Thr Gly Arg Gly Gly Leu Pro Arg Gly Pro Ser Trp Pro Ala 1 5 10 15 ctc ggc ggc cgc ggc gcg atg gag gcg ccg gcc gag cta ctg gcc gcg 97 Leu Gly Gly Arg Gly Ala Met Glu Ala Pro Ala Glu Leu Leu Ala Ala 20 25 30 ctg cct gcg ctg gcc acc gcg ctg gcc ctt ctg ctc gcc tgg cta ctg 145 Leu Pro Ala Leu Ala Thr Ala Leu Ala Leu Leu Leu Ala Trp Leu Leu 35 40 45 gtg cgg cgt ggg gcg gcc gcg agc ccg gag cct gcc cgc gcg ccc ccg 193 Val Arg Arg Gly Ala Ala Ala Ser Pro Glu Pro Ala Arg Ala Pro Pro 50 55 60 gaa ccc gcg ccc ccg gcc gag gcc acc ggg gcc ccg gcg ccg tcc cgc 241 Glu Pro Ala Pro Pro Ala Glu Ala Thr Gly Ala Pro Ala Pro Ser Arg 65 70 75 80 ccc tgc gcc ccc gag ccg gcg gcc tcg ccc gcg ggg ccg gag gag cct 289 Pro Cys Ala Pro Glu Pro Ala Ala Ser Pro Ala Gly Pro Glu Glu Pro 85 90 95 gga gag ccc gcg ggg ctg ggg gag ctc ggg gag cct gcg gga ccg ggg 337 Gly Glu Pro Ala Gly Leu Gly Glu Leu Gly Glu Pro Ala Gly Pro Gly 100 105 110 gag ccc gaa ggg cca ggg gat ccc gcg gcg gcg cca gcg gag gcg gag 385 Glu Pro Glu Gly Pro Gly Asp Pro Ala Ala Ala Pro Ala Glu Ala Glu 115 120 125 gag cag gcg gtg gag gcg agg cag gaa gag gag cag gac ttg gat ggt 433 Glu Gln Ala Val Glu Ala Arg Gln Glu Glu Glu Gln Asp Leu Asp Gly 130 135 140 gag aag ggg cca tca tcg gaa ggg cct gag gag gag gac gga gaa ggc 481 Glu Lys Gly Pro Ser Ser Glu Gly Pro Glu Glu Glu Asp Gly Glu Gly 145 150 155 160 ttc tcc ttc aaa tac agc ccc ggg aag ctg agg gga aac cag tac aag 529 Phe Ser Phe Lys Tyr Ser Pro Gly Lys Leu Arg Gly Asn Gln Tyr Lys 165 170 175 aag atg atg acc aaa gag gag ctg gag gag gag cag aga gtt cag aag 577 Lys Met Met Thr Lys Glu Glu Leu Glu Glu Glu Gln Arg Val Gln Lys 180 185 190 gaa cag ctg gct gcc atc ttc aag ctc atg aaa gac aac aag gag acg 625 Glu Gln Leu Ala Ala Ile Phe Lys Leu Met Lys Asp Asn Lys Glu Thr 195 200 205 ttt ggc gag atg tcc gac ggc gac gtg cag gag cag ctc cgg ctc tac 673 Phe Gly Glu Met Ser Asp Gly Asp Val Gln Glu Gln Leu Arg Leu Tyr 210 215 220 gac atg tagactgcgc ccacgggatg cacagcggcc atgcctgatg ctgtccccac 729 Asp Met 225 ccttgcccca tgcccttgtt ctttccagac ttctgtaggc ctaattttcc cttataaaca 789 tagatgcagg cgtacattct ataggtactt gccgagttct tgcagtgtgt atattacttt 849 gcaggaatca aaattgtttt attcagaaga caaagtccct gacccctctg gtttctgctt 909 gctggtgagg ttccagctgt tattgggctc tgaggccctc tcctgatcca aatctttttt 969 tgtttgtttg tttgagatgg agtctcactc tgtctcccag gctggagtgc agtggcgtga 1029 tcttggctca ctgcaacctc cacctccctg attcaagcga ctctcctgcc tcagcctccc 1089 gagtagctgg gattgcaggc atgcaccatc acacctggct aattttgtat tttcagtaga 1149 gacagcgttt tgccatgctg gccaggctcg tctcgaactc ctgacctcag gtgatccgcc 1209 caccttggcc tcccaaagtg ctgggattac acgcgtgagc caccatgccc ggccaatact 1269 acactcttat tctgccttac gaggatttct ggaagcttct gtaactgtag ggaagaaagc 1329 tgtaggggag catggttttt ttgttttgtt tttgtttttg agacgaggtc tcactgtcac 1389 ccaggctgga gtgcagtggt gccatcatga ctcactgcag ccttgacctc ccaggcgcac 1449 aaaatcctcc tctcagcctg agtaactggg actacaggtg tgtaccacta catccagcta 1509 aaggagagcg ttttttcctt tttctttttg agacagagtc tcactctggc gcctggtcac 1569 tgtgcccttc accttctggg ttcaagtgat tctcctgcct cagcctccct agtagctggg 1629 attacaggca tgcaccacca tacccagcta atttctgtat ttttagtaga gatggagttt 1689 caccatgttg gccaggctgg tctcgaactc ctgacctcag gtgatccacc tgcctcggcc 1749 tcccaaagtg ctaggattac aggcgtgagc caccatgccc agctgggagc gttctttcag 1809 caaaaagtct aattcagaga ctcaccttcc atcctggcac taaacaatag tactagaggt 1869 aagatctgcc aagaatttct ctcacttaag caggatactt actttaaata taattaggca 1929 agacttattt gagtacttga ctaattgtat ttaattagaa ctatgctgga tgctgtagac 1989 agaagaaata aaatactcaa cttggtccct atcttccagc aggttagagg cctttaggga 2049 agaaaagcct gtgtgcaggg aaagagaacc tcaccagaaa gtattcaata aaatgccaaa 2109 gtgatcttac agaacagtgc ctgtgacacc ggaggggatt gttctgtctt tgtgagtgaa 2169 catacaatga tggggataac tggtcctcat accatgcagg tcccatttct gatcacccca 2229 ctggcaggac aattcacagt tcttgagcaa actgagttag ggagggtatg ctaacgacag 2289 aacctatgca agttcttaga aatatttttt gtttgctgaa ataaagctca atcaacac 2347 <210> 9 <211> 1920 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3)..(827) <400> 9 gg cgg ccg gct ggg cgt gcg ctc gct ccc cga agc cgg ggc tgg gcc 47 Arg Pro Ala Gly Arg Ala Leu Ala Pro Arg Ser Arg Gly Trp Ala 1 5 10 15 gga gcc ggg cga ggg ctg gga gct ggg ccg ggt ccg ggg aca gcg ggc 95 Gly Ala Gly Arg Gly Leu Gly Ala Gly Pro Gly Pro Gly Thr Ala Gly 20 25 30 gag ggg cag ctg ccg gag ccg ggc agc cag gcc gct cag ggc agg gga 143 Glu Gly Gln Leu Pro Glu Pro Gly Ser Gln Ala Ala Gln Gly Arg Gly 35 40 45 cag ctg gcg ccg gtt ctg cgg tct ccg ggg ccc aga tgt gag gcg gcg 191 Gln Leu Ala Pro Val Leu Arg Ser Pro Gly Pro Arg Cys Glu Ala Ala 50 55 60 gcg ccc ccg gcc cga gag cgc acg atg ggg gcc ccg ctc gcc gta gcg 239 Ala Pro Pro Ala Arg Glu Arg Thr Met Gly Ala Pro Leu Ala Val Ala 65 70 75 ctg ggc gcc ctc cac tac ctg gca ctt ttc ctg caa ctc ggc ggc gcc 287 Leu Gly Ala Leu His Tyr Leu Ala Leu Phe Leu Gln Leu Gly Gly Ala 80 85 90 95 acg cgg ccc gcc ggc cac gcg ccc tgg gac aac cac gtc tcc ggc cac 335 Thr Arg Pro Ala Gly His Ala Pro Trp Asp Asn His Val Ser Gly His 100 105 110 gcc ctg ttc aca gag aca ccc cat gac atg aca gca cgg acg ggc gag 383 Ala Leu Phe Thr Glu Thr Pro His Asp Met Thr Ala Arg Thr Gly Glu 115 120 125 gac gtg gag atg gcc tgc tcc ttc cgc ggc agc ggc tcc ccc tcc tac 431 Asp Val Glu Met Ala Cys Ser Phe Arg Gly Ser Gly Ser Pro Ser Tyr 130 135 140 tcg ctg gag atc cag tgg tgg tat gta cgg agc cac cgg gac tgg acc 479 Ser Leu Glu Ile Gln Trp Trp Tyr Val Arg Ser His Arg Asp Trp Thr 145 150 155 gac aag cag gcg tgg gcc tcg aac cag cta aaa gca tct cag cag gaa 527 Asp Lys Gln Ala Trp Ala Ser Asn Gln Leu Lys Ala Ser Gln Gln Glu 160 165 170 175 gac gca ggg aag gag gca acc aaa ata agt gtg gtc aag gtg gtg ggc 575 Asp Ala Gly Lys Glu Ala Thr Lys Ile Ser Val Val Lys Val Val Gly 180 185 190 agc aac atc tcc cac aag ctg cgc ctg tcc cgg gtg aag ccc acg gac 623 Ser Asn Ile Ser His Lys Leu Arg Leu Ser Arg Val Lys Pro Thr Asp 195 200 205 gaa ggc acc tac gag tgc cgc gtc atc gac ttc agc gac ggc aag gcc 671 Glu Gly Thr Tyr Glu Cys Arg Val Ile Asp Phe Ser Asp Gly Lys Ala 210 215 220 cgg cac cac aag gtc aag gcc tac ctg cgg gtg cag cca ggg gag aac 719 Arg His His Lys Val Lys Ala Tyr Leu Arg Val Gln Pro Gly Glu Asn 225 230 235 tcc gtc ctg cat ctg ccc gaa gcc cct ccc gcc gcg ccc gcc ccg ccg 767 Ser Val Leu His Leu Pro Glu Ala Pro Pro Ala Ala Pro Ala Pro Pro 240 245 250 255 ccc ccc aag cca ggc aag gag ctg agg aag cgc tcg gtg gac cag gag 815 Pro Pro Lys Pro Gly Lys Glu Leu Arg Lys Arg Ser Val Asp Gln Glu 260 265 270 gcc tgc agc ctc tagactgatg cccctgcccc cgcccatccg cccccacgct 867 Ala Cys Ser Leu 275 gtacagagtg catgaggagc cgccggacca ccggggaccg actgcctgcg tccagccgcg 927 ccccatcccc gaggccgcct gtggccacca tgtcggccct ctttccacca ccccttgctc 987 agcatgtaag ccccacccac ccctgccctt tcagacccct gcggtgacct ggctcggaga 1047 aggtggccct gggcaccaag gggccaaccg ccctgaacac tggggcaggg accatgctgg 1107 ggcccggggc cacccccttc ctgtcaccag cttctgtgga gtccagtgtt ttgctttgct 1167 tgcttgtccc ccatcctgtc ctgagccggg gccccccagc ctcgcctccc tcctcctacc 1227 atccctcact tggacctggg ggtgtggaca gtgacccctc cctgaatatg gacttgaatc 1287 ttctgagcag aactagggcc tctcccctgg tgaagaccca gggaacccag gagggccctt 1347 ctggggcagt ggctctgcag ggtcactcat ggaggcctag gggaacagcg agatgcccca 1407 ccacctcctg gcgagtcctt cctgttcagc tccctgtgcg accctccagg gatgcagggg 1467 atccaggatt ctctgccctg tcacacggcg agtcagaagg gaggggcctt tccctcggac 1527 ccatggcccc aggcagagtt ttgcaccagc aggacccctt tgagggcctt caaggctctc 1587 ccaggagtcc ccctctgccg gccccccaat gccccagctc cctcttgggt cctgtgccaa 1647 gtccgcccca gggcctgggg ctgttgggag ccaagggccc cctggtactc agttccctca 1707 cgattcccga tcacgggcac acctgccccc tggttatttg taaatatttc tattggaccc 1767 aattctcctc ggaattggct ggcacctctg gttgccacag ctcagtgatg acgtggggga 1827 ggtgggagag gccgagggct ttgcctaggg gtgggttgcc ctgtatacat gatccagtct 1887 gtgactacca gccaacctga ataaagcggt ttt 1920 <210> 10 <211> 6385 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2801)..(4435) <400> 10 gatgggccag cagcacccca agccattcac tccatggggc ccggtaggac aggacaagaa 60 atggcttggg gcagggacag aacagccacc tgtggaggac gcagccctcg tcagcgacca 120 gggtcaccca tcacgggggt gtcccctctg gggtccctgt tcagagagaa gaggcctaag 180 gagcactggg gtccagtccc aagacagtct gatgtccagg gatacagagg cgcccccacc 240 ccctcacagc tctgcaggcc atgcacgaag gcctgtgtgg atgagaaccg tgtgtgttgg 300 taagaggcac agccctcgcc ctctggggcc tcgcctcctc tttgaactca gattctgaaa 360 gagcccccat cacattcccc tgtgcctctg cggccattcc ctgcagatca tctgcccagc 420 ggccccctcc accccacagg tgaccctcac aaggggccag gaggaacaga gccacagcca 480 tgcctcctgt ggccaggggt cctcctcagt ctagacagca cctgcgatgc tccacggcac 540 ctgtgtccct cctcctgtgc ctggtggcca ggacccactc cctggctcag actgtgggca 600 agacaggcag cacccctcag ggcagccatg tgagtcccat cgcacctgtc actcagccat 660 ggactgtccg tctgcccagc acccctcccc accgggggac ttcacggctc ttagggtcag 720 tgcatatgtg tgcgtgtgca tgtgctcgca catcctgaag tccccctggg ctcagccctt 780 cactggcttt gagctcctct gcctgaggac tcctgggtgg acaagtgggc tggccagagg 840 tgaaggcagc agtgactggg ggcctcggga gaaggctgtg gcccagtgtg acctccacag 900 ggcagaaagg gcatgcagag gagaggctgg acagcggctt gtaggaatga agtcccaggc 960 agcaaagaca ggagtacgag gttgaccaga tggctctggg gccgggggtg ttgaggattt 1020 ctgtgatttt aagtgatcac gtagtgaatt atttttacgc ttaacaaagc caccgaggta 1080 tggaaatcca tcctgacagc agaagactag gtgtgtgaat tcactttaga agtcactctg 1140 tgttgggggg tttggagggg cctctgtgga gtccacacct tgccccctct gccttctggg 1200 ctggccccgg gcttggaggc agaggcccct tggggtcctg gtgggatgag ccgttgtgtg 1260 gggagggcct actgtggcca cgctgggaga gaggctggac gccagctccg cagcaggatt 1320 gcacctcccc ctctcctcct ggccatgcct gtgctgaggc cctgggaggg cggtgcctga 1380 cctcagagaa tgtcgctcta atggtggaat ttcaggtact gccacgtagg gaagagtctc 1440 gtgggaaggg cattttccag cctctgtcac aaaatctcca agggaattca gacctcatct 1500 agttccatcc tcttattttg cagaagagga ggctgagggc ccgggagacc aaggctgccc 1560 acctgtgggt ggcagagccc aggcacccag cgcccccagc tccctgcccc ctgctccttc 1620 cgcccaccca cacacccagc agctggcctc tctgcggcca gcctgctcgc ttgctggaca 1680 cctcgacagc cccaccgcca gccgcaggtg cgcgcaaggg acccgtcaca agcatcttgc 1740 cctgtggcct cctgagaagc gagtgagtgg accacagagg tcatttccca gccacgtggc 1800 caggcccagc ccgaggcagg accgggctca gggtgggaag cagggctgct cagaggagcc 1860 aggatggggc ggccaagccg acggcctgcg gggccgcctc cggactccta acgcggcagg 1920 tgtttttact cctgctgtca cttatgtatc agtgtcactc ttgcttcatc ttatctgttt 1980 ccttccaggt ccagctttag gggcagctgc caggccttag gagcctttgc aatggttttg 2040 tattcctgta gacaccagat ataaacagat ttatatattt gtgtccctcc cctgctcccc 2100 ccagttcccc agcccgacgc acactctaca cgcaggccac tctgacctct gaccccgtgt 2160 tccatgtggc aggagggccc gccccgggcc aggccccagg tcatggctgc tggctgtctg 2220 tggcggaagt ccttggttgt ttcctctccc ctcctcccgg ctctcaccat tctgtccgtc 2280 tatctcgtct tgtcctcagt ttcaaagcaa tgtcacgaag ggcttccttt ccatgcctaa 2340 aaggaaacaa tatgtttttg gaaagaggtg gggttggagc gggttctggg gcaacttggg 2400 gccctcggtc ttggggcgat cagaggatat ctctggattg gctggcatca cagccagttg 2460 ggagcctccc aagcctgggt cacgttggag aatctgccac ccaaggcagg cagggccggg 2520 ctgggatgcg tcggcctgct ttggtggaga caccagggcc tgcagtgggc tgaaccgtat 2580 tgtttccctt tgaggccagt cctggtcctc gtccccatcc atagctcatg ctttttgatt 2640 tgcatctttt tttgcatgga catgccgagt agtgataagc agggttttct gttcttttgg 2700 gcgtctctgg tcagactctt ctctttcaga tcccgtgtca cagcattagg ttcaggtgtg 2760 tcattgccgt gtcctttgag ccctaaaacc aagggcatga cca agg tgt gca ggg 2815 Pro Arg Cys Ala Gly 1 5 aga tct agc cct gtg agg aag cgg cac ggt ggc cgc agg gca gga ggt 2863 Arg Ser Ser Pro Val Arg Lys Arg His Gly Gly Arg Arg Ala Gly Gly 10 15 20 aag gac acc ctg gtc tct gtg cct agg tcc gtg caa gac agc ggc cag 2911 Lys Asp Thr Leu Val Ser Val Pro Arg Ser Val Gln Asp Ser Gly Gln 25 30 35 ggc ggc cgg gag aag ctg gag ctc gtc ctg tcg aac ctg cag gca gac 2959 Gly Gly Arg Glu Lys Leu Glu Leu Val Leu Ser Asn Leu Gln Ala Asp 40 45 50 gtc ctg gag ttg ctg ctg gag ttt gtc tac acg ggc tcc ctg gtc atc 3007 Val Leu Glu Leu Leu Leu Glu Phe Val Tyr Thr Gly Ser Leu Val Ile 55 60 65 gac tcg gcc aac gcc aag aca ctg ctg gag gcg gcc agc aag ttc cag 3055 Asp Ser Ala Asn Ala Lys Thr Leu Leu Glu Ala Ala Ser Lys Phe Gln 70 75 80 85 ttc cac acc ttc tgc aaa gtc tgc gtg tcc ttt ctc gag aag cag ctg 3103 Phe His Thr Phe Cys Lys Val Cys Val Ser Phe Leu Glu Lys Gln Leu 90 95 100 acg gcc agc aac tgc ctg ggc gtg ctg gcc atg gcc gag gcc atg cag 3151 Thr Ala Ser Asn Cys Leu Gly Val Leu Ala Met Ala Glu Ala Met Gln 105 110 115 tgc agc gag ctc tac cac atg gcc aag gcc ttc gcg ctg cag atc ttc 3199 Cys Ser Glu Leu Tyr His Met Ala Lys Ala Phe Ala Leu Gln Ile Phe 120 125 130 ccc gag gtg gcc gcc cag gag gag atc ctc agc atc tcc aag gac gac 3247 Pro Glu Val Ala Ala Gln Glu Glu Ile Leu Ser Ile Ser Lys Asp Asp 135 140 145 ttc atc gcc tac gtc tcc aac gac agc ctc aac acc aag gct gag gag 3295 Phe Ile Ala Tyr Val Ser Asn Asp Ser Leu Asn Thr Lys Ala Glu Glu 150 155 160 165 ctg gtg tac gag aca gtc atc aag tgg atc aag aag gac ccc gcg aca 3343 Leu Val Tyr Glu Thr Val Ile Lys Trp Ile Lys Lys Asp Pro Ala Thr 170 175 180 cgc aca cag tac gcg gct gag ctc ctg gcc gtg gtc cgc ctc ccc ttc 3391 Arg Thr Gln Tyr Ala Ala Glu Leu Leu Ala Val Val Arg Leu Pro Phe 185 190 195 atc cac ccc agc tac ctg ctc aat gtg gtt gac aat gaa gag ctg atc 3439 Ile His Pro Ser Tyr Leu Leu Asn Val Val Asp Asn Glu Glu Leu Ile 200 205 210 aag tca tca gaa gcc tgc cgg gac ctg gtg aac gag gcc aaa cgc tac 3487 Lys Ser Ser Glu Ala Cys Arg Asp Leu Val Asn Glu Ala Lys Arg Tyr 215 220 225 cat atg ctg ccc cac gcc cgc cag gag atg cag acg ccc cga acc cgg 3535 His Met Leu Pro His Ala Arg Gln Glu Met Gln Thr Pro Arg Thr Arg 230 235 240 245 ccg cgc ctc tct gca ggt gtg gct gag gtc atc gtc ttg gtt ggg ggc 3583 Pro Arg Leu Ser Ala Gly Val Ala Glu Val Ile Val Leu Val Gly Gly 250 255 260 cgt cag atg gtg ggg atg acc cag cgc tcg ctg gtg gct gtc acc tgc 3631 Arg Gln Met Val Gly Met Thr Gln Arg Ser Leu Val Ala Val Thr Cys 265 270 275 tgg aac ccg cag aac aac aag tgg tac ccc ttg gcc tcg ctg ccc ttc 3679 Trp Asn Pro Gln Asn Asn Lys Trp Tyr Pro Leu Ala Ser Leu Pro Phe 280 285 290 tat gac cgc gag ttc ttc agt gta gtg agt gca ggg gac aac atc tac 3727 Tyr Asp Arg Glu Phe Phe Ser Val Val Ser Ala Gly Asp Asn Ile Tyr 295 300 305 ctc tca ggt gga atg gaa tca ggg gtg acg ctg gct gat gtc tgg tgc 3775 Leu Ser Gly Gly Met Glu Ser Gly Val Thr Leu Ala Asp Val Trp Cys 310 315 320 325 tac atg tcc ctg ctt gat aac tgg aac ctc gtc tcc aga atg aca gtc 3823 Tyr Met Ser Leu Leu Asp Asn Trp Asn Leu Val Ser Arg Met Thr Val 330 335 340 ccc cgc tgt cgg cac aat agc ctc gtc tac gat ggg aag att tac acc 3871 Pro Arg Cys Arg His Asn Ser Leu Val Tyr Asp Gly Lys Ile Tyr Thr 345 350 355 ctc ggg gga ctt ggc gtg gca ggc aac gtg gac cac gtg gag agg tac 3919 Leu Gly Gly Leu Gly Val Ala Gly Asn Val Asp His Val Glu Arg Tyr 360 365 370 gac acc atc acc aac caa tgg gag gcg gtg gcc cct ctg ccc aag gca 3967 Asp Thr Ile Thr Asn Gln Trp Glu Ala Val Ala Pro Leu Pro Lys Ala 375 380 385 gta cac tct gct gca gcc aca gtg tgt ggc ggc aag atc tac gtg ttt 4015 Val His Ser Ala Ala Ala Thr Val Cys Gly Gly Lys Ile Tyr Val Phe 390 395 400 405 ggt ggg gtg aac gag gca ggc cga gct gcc ggc gtc ctc cag tct tac 4063 Gly Gly Val Asn Glu Ala Gly Arg Ala Ala Gly Val Leu Gln Ser Tyr 410 415 420 gtt cct cag acc aac acg tgg agc ttc atc gag tcc cca atg att gac 4111 Val Pro Gln Thr Asn Thr Trp Ser Phe Ile Glu Ser Pro Met Ile Asp 425 430 435 aac aag tat gcc ccc gct gtc acg ctc aat ggc ttc gtt ttc atc ctg 4159 Asn Lys Tyr Ala Pro Ala Val Thr Leu Asn Gly Phe Val Phe Ile Leu 440 445 450 ggc ggg gct tat gcc aga gct acc acc atc tac gac cct gag aaa gga 4207 Gly Gly Ala Tyr Ala Arg Ala Thr Thr Ile Tyr Asp Pro Glu Lys Gly 455 460 465 aac att aag gcg ggc cca aac atg aac cac tct cgc cag ttc tgc agt 4255 Asn Ile Lys Ala Gly Pro Asn Met Asn His Ser Arg Gln Phe Cys Ser 470 475 480 485 gct gtg gtg ctt gat ggc aag att tat gca act gga ggt att gtc agc 4303 Ala Val Val Leu Asp Gly Lys Ile Tyr Ala Thr Gly Gly Ile Val Ser 490 495 500 agt gaa ggg ccc gcg ctg ggc aac atg gag gcc tac gag ccc aca acc 4351 Ser Glu Gly Pro Ala Leu Gly Asn Met Glu Ala Tyr Glu Pro Thr Thr 505 510 515 aac aca tgg acc ctc ctc ccc cac atg ccc tgc cct gtg ttc aga cac 4399 Asn Thr Trp Thr Leu Leu Pro His Met Pro Cys Pro Val Phe Arg His 520 525 530 ggc tgc gtc gtg ata aag aaa tat att caa agc ggc tgacatcagc 4445 Gly Cys Val Val Ile Lys Lys Tyr Ile Gln Ser Gly 535 540 545 agaaagccca cgataagact gtggacaagt ctggtgaggc aagtgccacg caatgataat 4505 tttccagcga caccaacaag aggccaacaa aacacaatca aggaactcac tgcgctcaac 4565 atgttgaata ttctctacat tgaatgtaga aaatcatcct cgcctttgga tgaaacggag 4625 gcaccgcgct tggagccgca ggaaccacga tcccgccatg gggctggctg cctcctgaac 4685 aggggcgctc gctctgccag gtgcaataga gtttcacgta tttttcaact gggagagaga 4745 agctgttttt tccttcctgc agagcaagct tgatccctaa acaaccatag atcagttatc 4805 ttatgacaac attaggcatc aggctctctt ggaataagat caaagtgtcc ttatcacttt 4865 gattcctact tttgtttctt aaccgatcta cactttcagt ggccgacaga aaacgaggga 4925 caatactgtg catcacaagg cctaggaggc tgctggtccc cactggggct gaagagaagc 4985 ccagctgccc acgcggagcc aggggtggca gctgtgggac agccagggag cagggacagc 5045 ggtctgtcct tcacaggttt ttctactgtg tttttgctgg agaaggacag tgattgcgct 5105 agctttctct tacccggtat gaattattta gatttctgag gcattttctt gataaacaaa 5165 aggctatttt taagtactga gaggaggagc aggccacaag agggataatg ttgtgggaat 5225 tcccaaagct ctttgtaggt agtgccagag gggggctttt gctctcattt ttctatgtgc 5285 agaatagagg atctctcctg gggtgggcga tgcccccatt ttatttttag aaaaagtaac 5345 tcccagacag ccccataaaa gctgtgccca aggaagaaga gtctgctcta gaaggagccc 5405 ggttctggct caggacaccg gcccagctcc ctccatgagg tcaagctgag gaccaggcca 5465 gtgggaaggg aaggagggag aattagcgtc tataaagcac aggagactat ttttgatatt 5525 catagctata tattaaggca cctgccacaa gagctctcag gatggggaca gccttcttag 5585 tggagccatg gcagcaaggc ctgagggcat gagcagaacc actcttcttg tcacatacga 5645 acctgagaaa agggaagcca ggagggaggt cacaccatgg ctcaaaaggg aaaggccttc 5705 ccacttgtcc ttagcccctc aaacctcaca cggtcaacag tttccattcc agggcaggag 5765 aatgctgccg ccactgcgct gttgagttga agttggtacc aaatacacat ttaccacttt 5825 tatatctggg aagtcaactt gccatcgttt catgataaca accatttata agagaaaaag 5885 acaggacacg ctttccatcg ttcagtattt gatgacacaa aattccagtt ctaacgttgg 5945 gcatcaactt ctagcactac gagtgtggct cccacttgga caagataccg agcttcgtta 6005 tgcagttttt aatattattt attattttaa aaagtaataa gcacaaaact acatacattg 6065 tatgtcattt aaagtattta tgtcaaacag ggtgcaagtg tgaacccaag gactggagca 6125 caaattccta actgcctggg gcagggctaa tgttagcatt ggtgtgcgtc tgcctccaaa 6185 ggaggttcta gttgtcagcg agactcaaca cagatgacat tgaaattcgt ttctctcctc 6245 atctatcaca ctggagcaaa actggctatt tctgtgaatg atataaaaca gggttctctg 6305 taatggtatt gtacatagta tatgtttact gttaagttct tgttatatta taataaatat 6365 atttatagat ctagacttgg 6385 <210> 11 <211> 6522 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (5610)..(6137) <400> 11 ggccgtcctt tttttttttt tttttttagc aatatatata tataatttat ttacattcac 60 gcccgataaa acccctatgt gccccggcgg ccgggcaagg ctgtgtacat aaggccaaga 120 gtaagtgcgt gaatgcactt aagacaaagt caggacacga gcttcacatg acaggccccg 180 cgtggggcac cagccagccc tggggacggg cacgccacgc cacacacaca ctcaccactg 240 tacagcctgg gactcccatt gcatattcac aggccccgcc gggcagggca cctcaaggct 300 gggggagggg caggggcagg gaggagccgt ggggtgtccc tgggtgggtg gagagggcag 360 catgtgagag gcaaatgtgc accaacactg ggcgtgagac gtgagcagcc tcaggtgtac 420 ggcatgagat gtgtgtggtt ggggggtgtc tgcgtgaccc gggagggggg tgtgtgtgag 480 atgagcacac gaggcatgcg tggcacgtgc tcgtgtggtg gtcgtgtgcc tgaatccagg 540 ggctaccccc tgtccggctg tggccctcgg tcctgcaggc ttggagcagg gcccctcaga 600 cgtgccccta cccagcaggc acagaaatgt ttgcataagg tccagctcag gcaggagctc 660 tggggccctg gcccaggccc agtgtgtgcg tgcatggccg tgtgtatgcg gggcccctgg 720 agagggacgg gaggagaggt agcatcacac gcacatacac acacacagat gggctgggcc 780 tggcccaggc tccaggcact gtccctcctg ggccctgggg ccgagtgtga gtggcagtgc 840 cagcctggct aggcaggcca tggagaggtg ggagttcggg cagggtctga aggaccagca 900 ttaagggaca gcttcggccg ggagggggcc tgtccgagca gctctccccg gtgtggggaa 960 gggcccctgt ccggcttctg cctgtccttg gtgggtgcca aagctggtga gagtgtaggt 1020 gtcgggcctg gccggcctca gcactcagcc tccgacactg tgaagaggcc agcgtctggc 1080 tggcccagtc cagccactgc tgcagccagc tggctgaggt tgccgttggg gaagtgccgc 1140 gcctcccaca ggttgaggat catggctgtg gggctgggct tggaggcaaa gaagctgaga 1200 tggctgtgga ggggaggggg gccgtcagca gcctggcctg gccccagctg acacctcctg 1260 ccccccctgg cccaccccag ggcagggcct ccccgaagcc aaacacaatg actgccccgg 1320 ccactagtag atgcggcaca ggccccacag ggcctcctgt ccacctcacc caccccgccg 1380 ccgggcagga ctgtcggtgg cctgcgcagg ccctctctgc ccctctcccg cccacctgtc 1440 caggtggagt ttctgggcca gagtccgcca gtcggcaccc cgcctacagg gtgggtccag 1500 gctggaaatt atcttctgcc gaatgaggaa ggggatcttg aaggcactgg ggcccaccag 1560 ggctgggacc cccgcttcac tctccagagc cagcagctca gcaaaccttg tgtcctggag 1620 gtgggaggga aagaggtgcc tgttagaact ttccccaggc ccgggtccac cgccacctcc 1680 tgctggggga gctcccagac tcccccagag catgggggcg gcatgagcac tggtacttcc 1740 tgggcacctc ccatgtgcca aggcccttct tactggggct cggaggtgca gcgacctgcc 1800 caaagccaca tagccagaga gcagaggagc cctctgtggc ctccctccct ctccgccctt 1860 ctcccctcca agtcactctg cccagcctct gctgacactc aacacacaca gctctcttca 1920 cggcctgagt cccccctgcc cagctctcac cgccagaaat gctcttcccc ttaatgccgc 1980 agccaaactg gctcattctt tggggcccag tacaaagccc ctcctcaggg aagccctcca 2040 gggtctcccc tcctgctgct cccatgtccc ctgcactccc ctccccaagt cccatttgca 2100 cctgtgcctc cctgtctctg agtctgggag gaagctgcca aggggtttct aggaggaggt 2160 gggcctgggg acaggcggga gggagagtgg gtggcagggc aggcagggca ggagcgtttt 2220 gggggctggt ggggagttgg tagtggaagc acgtcacggc ggtgcggcag cccctcccgt 2280 ccaccttggt gatgttgaag ttgatgctga agctctgccc gtcgccctcc acctgccaca 2340 cccacagctt gcaggccagg tcactagtgc tggggctgac acgctccagg gtgaaggtgc 2400 agtgcaagta ccgctgcgtg ccattccaga tgtgataaaa ggggatctcc tgatggggtt 2460 gcagagagga ggtgtcaggt gagcccaagc tccaggcctc ttgtgcgctg gccacggccc 2520 tggccctcac ctggtagctg acaaggagct tactcttcca cagggagctg ggcacatcgt 2580 ggatggatag gcgcaggttg tggtaactgt ccttgaagtg caggacccgt ggctcctgga 2640 tcagctgtcc ccccagctgc ttctccagct gcaccacctc ctgcagtgcc ccaggtggtc 2700 agcccaggcc cctccccact gcgcccaagg caggcagtcc acagggccag gcatagctcg 2760 gcctcccagc ggcggggggt gaggggcggg agataccttg agtgcatcgt gggtgtcatg 2820 caggcagtag acccggatgt tgtactcgag ggaggtgcag gccaccggcg caaacagaag 2880 cagcttgagg cgcttggcgg cagccacgct gagggcctct cccaccaggg caaagcggcc 2940 cagctgctcg gtgaagacgt agcaggcact ggcctccagc tggcagtagt agaggtggga 3000 gggcgcctcc tcgcccaggt gcagcacatc ctgtgggcag gggtcagtgg gtcaattcgg 3060 cccagcctca gagccctagg gccagctgtg gcttcaagaa gtggccggag actggggagg 3120 ggtgggggtg cggctcagga ccacccagcg gtggaaggcc gggtggagcg tgcagttagc 3180 ccacgttccc ttctggagcc cgggtcagtt ccctgctcac ctcccagctg ccctcgcacg 3240 actgcttttt gaggcgcagg ctccagctgt cagggctggg ctccccacag tggtccatag 3300 ccaggatgac tggccgggtg agcaggacgc cagggggtcc acagctaacg atgggactca 3360 gcagggtctg acagccagct aggggcaacc tcaagtgggg aaatatgggt ggggagggaa 3420 aggtgtcagt ggcccatcct gggtcctgag ggctaggcca agggcagggc agcagcatcc 3480 caggggccag gggcttgggc tgcaggacca cgtggggctt aggcacagct ctttcccccg 3540 ccgcctcggg ccaggcacaa cagtgggtgg gcagggggct tcctggggac cgaaggcagc 3600 aggcaggtcc ctcccacccc cggcaacagg gcccgcggcc acacctcacg tcttccggct 3660 tgtgcagcgt gaggtagatc tcatagatct tccctcgggg tatggcatct ggggggatga 3720 ggaggctgat tcctggaacg gcaggaagag ggccagggct tacccactgc caaagcaccc 3780 aacaccccac cacacagccc ctccaggagc cttcctgtga ggactgactg gtgccagccc 3840 ggcctgggga cagaggggcc tcaaagactg ccgtgctgac caaccacccc cacaggcatg 3900 aagctgagtc aggggcaccc catgagcaac tgagggaacc caggtgggga aagcatgcct 3960 ggctagctca ggcacagaaa acttggggac agaaggtatg cggtaccgac ctcccttgtc 4020 ccctgaaagg cactggaggg gaccagggta tcccttgctt aaaaccttcc ctgcccccgg 4080 atgaagtcca gctccctggc ctggcattga agggcctttg cctctggccc ccactgcctc 4140 tctagcccag ccagtgctac aaagttggtg gttctggaac cactgcctga gcccccactg 4200 ccctcccgtc ctgctccagc tcccctctcc cttgctcctt ctactctctg ccatgccatg 4260 gtccctgcag gtggggtggg tcttgaataa cctatctcct gggctggatg ccctcccgtc 4320 ggctggcttg cctctgctcc aacgtcttgg aggagcagga tcagcgtgtg agtggagagg 4380 ggagtggttc aacagggaga tggtgggaca ggatccggca aagacggggg ccagggagtc 4440 cctctagagg tggtgagcag ggactccccc agacagggag cccttacatg aggaggggct 4500 cccagctcag gacatgggga gggagaggaa ttccatgact ttaccccacc aagtccaaaa 4560 gcaaatgcac actccctcgt gggcagcgca gagcagggct gggctggtat caccgtttca 4620 ccggagaggg cagagtcaca gccactgctc ccttcactgg cctgcactgc cccgcggtcc 4680 cagctgtagt gttggtgaca atgccagaca tcctcgcagg aaggctctcc atggggaagg 4740 tacacgcact tacatcctca ttcatcaact cctaatgctg ggtactcagg acggcgaagg 4800 aaaaccacag accccactct catgaagttc ttagcccagc aggggagaag gacaagtcaa 4860 ccacagcaca ggatgcgggg gaagtggcag ccaccccccg gcctggggag cgaagagcaa 4920 gggctgccgg gccccactgt tcgcctgcgt ctctgtaaga gctgacagat gccgtctcac 4980 ctcgtcatcc caacagcccc atgaggggtt cgttatcatc cgtgtggacg tgaggcacag 5040 acggcaagag ctgtcaggcg gggacccaaa agagaagtcc cagctgagct ggtgggaggg 5100 gcagggggtc ggtgcatgca gagggcagca ccgtgtgtcg gggatgttga gtccatggtg 5160 gctgccgtgt gcgggacgat gtgtgtgagg gaagaggctg aagcagctgg cctgcagggg 5220 acaggtcttc tctgtggtat catgtgggct ttgcaggggg cagaggggag cccagaaggg 5280 attcgagcac gagagggtca tgatcaactc tggcttcatt tggtgaagtt ttacagcaag 5340 gaaccaggta aggggtttgg tggcccgtgt caggagaggc agcaagggag gacaagagca 5400 ggaggtggca ggagctattg aggagggact ggcgtgggac tgaagctggc ggggggcaag 5460 agaggacgag cagcaggtca aggtgacccc aagtttccgg cttgagcaac tagacgatcc 5520 gtgaactggg ggaagccagg aatggggagg ctctggggga gggtgggaga cggttctgtt 5580 ttaggcacca ggagtctgag gtgatgtga gac atc cag atg gag ctg gcc agg 5633 Asp Ile Gln Met Glu Leu Ala Arg 1 5 agg cag ctg ggt gta cag ttc tgt cgc ccg gga gaa ctg cag gct aag 5681 Arg Gln Leu Gly Val Gln Phe Cys Arg Pro Gly Glu Leu Gln Ala Lys 10 15 20 gat ggg gga gtg gga gtt atc tgc aca gac acg gcg att aaa gcc atg 5729 Asp Gly Gly Val Gly Val Ile Cys Thr Asp Thr Ala Ile Lys Ala Met 25 30 35 40 gag tgg gcg agg ccg ctc ggg gag aag ggc act ggg agg gag ctc gga 5777 Glu Trp Ala Arg Pro Leu Gly Glu Lys Gly Thr Gly Arg Glu Leu Gly 45 50 55 ggc aca cct aca ttt atg gaa cag gca gct gga gag ggg caa gca aac 5825 Gly Thr Pro Thr Phe Met Glu Gln Ala Ala Gly Glu Gly Gln Ala Asn 60 65 70 cag gag cgc atg ggg tca tct aag ctg agg gac ttg gga att tcg ggt 5873 Gln Glu Arg Met Gly Ser Ser Lys Leu Arg Asp Leu Gly Ile Ser Gly 75 80 85 ggg agt ggc cag cca tgc cag agg ctg cag cca ctt ctt gca agg cag 5921 Gly Ser Gly Gln Pro Cys Gln Arg Leu Gln Pro Leu Leu Ala Arg Gln 90 95 100 cca tgg aaa gag ttc ttc aga ggg ttt cgg tgc tgg ggt ggg tgg aag 5969 Pro Trp Lys Glu Phe Phe Arg Gly Phe Arg Cys Trp Gly Gly Trp Lys 105 110 115 120 cca gga tgc agt ggg gac tcc agg atg gcc tct gcc cag gcc cgt gct 6017 Pro Gly Cys Ser Gly Asp Ser Arg Met Ala Ser Ala Gln Ala Arg Ala 125 130 135 cat ctg ttt gcc ctt ggt tgt ctc cct gct cag ttg caa gct cct tgg 6065 His Leu Phe Ala Leu Gly Cys Leu Pro Ala Gln Leu Gln Ala Pro Trp 140 145 150 ggc cgg ggc ttg ccc tac ctc tgg gcc cag ggc ccc aca tgg aga ctg 6113 Gly Arg Gly Leu Pro Tyr Leu Trp Ala Gln Gly Pro Thr Trp Arg Leu 155 160 165 gaa caa gta ggc tgc ttg gct gtg taaatgaatg gacaattacc ttgtgcccac 6167 Glu Gln Val Gly Cys Leu Ala Val 170 175 aggcaacaag aggaagacag ctctggccac ggcctcggtg ccagccaaga ctgggttctc 6227 cccaaaactc cacccccttt ccttgctgat ctgtcacggg acaccgaggg gcacgagagg 6287 aacgtccggc tgtcccgtcc tcctccagga gggaagtgga gctctcagag ccccctgggg 6347 tccttcctac ctgtattagg gatcatcagc cggcccccga ggaagttgaa ggtcccatag 6407 gtcatgttgc tggtgcctcg gggcagggag cggaagtagt tctgggtgga gaggcgggag 6467 acgaactcct cggcctcaga ggtgggagag ctgtggtgca gtgtgtggcg gccgc 6522 <210> 12 <211> 5155 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (745)..(1179) <400> 12 gaaagtatta taatagaata aagtaattcg gccgggcgtg gtggctcaca cctgtaatcc 60 caggactttg ggaggtggag gcgggcggat cacgaggtca agagatcgag cccatcctgg 120 ccaacatggt gaaaccccat ctctactaaa gatacaaaaa ttagctgggc gtggtggcgt 180 gcgcccagtc cgagtagctg ggactactcg ggaggctgag gcaggagaat cgcttggacc 240 caggaggtgg agtttgcagt gagccgaggt cccgctactg cactccagcc tggcgacaga 300 tcgagactcc atctcaaaaa taaaaataaa acaaaataat aataattcag aagctgtctg 360 aggggacatg acttatctga caggcttaga aacaaaataa gcctttttgt ccagaagatc 420 tgaaataaag ctgtgtggtg accgccatca gtttattcaa aagattactc agggactact 480 ccccattttt tcaagacaga attctgtcat acctgagaag aaatgatcaa gtaagttcag 540 ataataggat ccaaaggaaa caaaagataa gacatttagt ataacaacgt aaatgtagag 600 aacaaagaca ttgtctcaag tccctttctt ttgggggaac atcttcctgt taacaacaac 660 aacaacaaca aaaactaaaa aagcccacat gtgtttcaag ttaacctatt gttattattg 720 gaataattat gaacaaggct ttaa aaa tta aaa tca agg tca aac aaa aag 771 Lys Leu Lys Ser Arg Ser Asn Lys Lys 1 5 aaa aat agt gtt aat agg tgg cca tat aac ctt cca agt ttt tgt tta 819 Lys Asn Ser Val Asn Arg Trp Pro Tyr Asn Leu Pro Ser Phe Cys Leu 10 15 20 25 ctg att tca gta atc gtc tgc ttc tct gta ttg ata gtc atg ttt tat 867 Leu Ile Ser Val Ile Val Cys Phe Ser Val Leu Ile Val Met Phe Tyr 30 35 40 aat aat gat tat att ggc caa cct gat ttt tct att gac agt ata tct 915 Asn Asn Asp Tyr Ile Gly Gln Pro Asp Phe Ser Ile Asp Ser Ile Ser 45 50 55 gaa ata ttt cct gtg tcc tta agt att ttt cac agc ttc cca ttt tac 963 Glu Ile Phe Pro Val Ser Leu Ser Ile Phe His Ser Phe Pro Phe Tyr 60 65 70 atg tac gat ggt ctg cca tat cta gta agc ttt gtc aga tcc aaa ata 1011 Met Tyr Asp Gly Leu Pro Tyr Leu Val Ser Phe Val Arg Ser Lys Ile 75 80 85 cta aat gct gcc ttt ctg tcc cca gtg tct ttg ctc agt tca aaa gcc 1059 Leu Asn Ala Ala Phe Leu Ser Pro Val Ser Leu Leu Ser Ser Lys Ala 90 95 100 105 aca gaa gaa gtt ctg gac gat gtg ggc ctt caa tct tct aag atg gga 1107 Thr Glu Glu Val Leu Asp Asp Val Gly Leu Gln Ser Ser Lys Met Gly 110 115 120 ata gaa aga aga gga tct acc cag acc agg acc ctg ctg ccc aat ctc 1155 Ile Glu Arg Arg Gly Ser Thr Gln Thr Arg Thr Leu Leu Pro Asn Leu 125 130 135 agg tct aca tct gcc tca cca aaa taatacagtg gccagaaacc tccctgctaa 1209 Arg Ser Thr Ser Ala Ser Pro Lys 140 145 catcatagtt tgtctgtgat gcagaaatgc ctctgttttg ttgttgtttt gtttttgtag 1269 agacagggtc ttgctctgtc acctaggttg gagtgcactg gcacaatcat agttcactgc 1329 agccttgaac tcctggactc aagcgatcct accgcctcag cctcccaagt agctgggatt 1389 atgggcatgc gccatcatgc ctagctgatt tttattttgt agagactggg tctcactatg 1449 ttgcccaggc tggccttgaa ctcttgacct caagcgatct tcctgcctca gcctccccag 1509 ttgctgggat tacaggcgtg agccatcgtg cctggcccca gaaatgcttc tcttctatga 1569 ctttgttcag tggagacctc tgtgatttgg gggaggaaat agatttatcc agaaccccaa 1629 tttgcccgaa ttatgtatga tgggaaatag tttgagacct ggaatggaag agcatcacag 1689 caatattaag taacttaagg tctgtcagga acactaatgc aaaactggtc tcaaggtctt 1749 tcttcttcct ccagctctgg ctttctggat ctgtgcttct ctggtagagg aaccctgagg 1809 actgatctac tcttgcagtt ctaaaaccat ggcccatgta agttcacgtt tttctccttg 1869 ttgaaatatg tgtgtgttgg ccaggcacgg tggctcaggc ctgtcatccc aacactttgg 1929 gaggccaagg cgggtggatc acctgaggtc aggagtttga caccagcctg gccaacatgg 1989 tgaaaccctg tctctactaa aaatacaaaa acagcccagc atgatggcag atgcctgtaa 2049 tcccagctac tcaggaggct gaggcaggag aatcgtttga acctgggagg cagaggttgt 2109 agtgagccaa gattgtgcca ctacactcca gcctggacaa gagcgaaact tggtctcaaa 2169 aaaaaaaaaa agaaatatgt gtgtgttttt aggtcatgaa ggtattttta ttaattttcc 2229 tgaaatttcc taccaggaga ggctcatcaa ataacatgct tccagctctt attcttccag 2289 ttcccagcat ccacccaata tgtcccatta taaacctcct ttgttcatgt aattactgag 2349 caaattattc agcatgtctt aagagccctc tatcaagggc agtggtggag ttaagtcctt 2409 ttaagtaaag atttgtgctt tttgggtcaa gtctagtttg gtaagataga gtcaatggtt 2469 gtatttgacc atccataaca aaacttaaat tatcaccgac tggagatttc caggaagtga 2529 agatgaaaat ttggtattga atgatcaaac tcagtcattc attgggtgaa atctcatgct 2589 ttgtgtggtt cagtaaatga ctggggactt gcaaacttgg aggttatgga ttttggcaag 2649 aaacccctca ggaataaata tcaggactat tctgatgttg gatggaacct actaaattta 2709 gatgacatgt atataattca ttattcttcc ttagtattct ttaactcaat gcatttgtta 2769 tctattatta cataacaaat tagaccaaaa cttaatggct taagacagca aacatttatc 2829 tcacagtttc tttggatcag aaatccagac atggcttagc ttgcctctct ggctctcgat 2889 ctcttacaag gagatccagg ttttggtcag gactacagtc atcttaaggc ttaacttggg 2949 gtggatcttt ttctaagctc actcaactag ttgttaacag gatccagttt ctcacaggct 3009 tcagactgac agtcttagtt cctcattcgc tgttgcctgg aagctgctct tggtttattg 3069 tcatgtgggt ctgtccatag aatagcttaa aacatggtgg ctgtgtttta atcagtgagc 3129 aaatgagaca tcaagagagg gagagaaata cagaaaaagt gctgaagtaa catttcagca 3189 ctgtagctat tctgcttatt aagagcaagt cacttggttc agcccacgtg caagggaagg 3249 agattacaca agcatgtaat actatcggat ggggatcttt ggtaacctat atagcaagcc 3309 aggtgctcag tgagagatgg tagagagcca caaaagagaa tgtcattata agtagcaagt 3369 gaacacagaa tcctagaact ggggaagacc ttaaaaatgt tgtgtatcct aactgcattg 3429 taaacaagta agtctgatat tgccctaaga tataattctc atgtgccccc aaaatacatg 3489 gatttgtcaa aacaagagaa aaatgcttat ggtgagatct gatgtaatga agtatttaat 3549 gcttgagaga attcttaatt ttatgtaaac cctattttct aaaatcaagg ccaggtgctg 3609 taatccctgt aattccaggt gttcacacct gtaatctcac cacttaggaa ggctgatatg 3669 ggagcattgc ttgagaccag gagttcaaga ccagcctggc caacacagca agaccctgtc 3729 tctattaaaa ataataataa tcaagacttt atacttcatt tggggaaaat atctgattaa 3789 attttttgct cctcttaaaa gcaaaaattt tccccagcaa ctcatatgta tttaaaaatt 3849 tatatggcag ataccaatca gacattatgc ttatattcac tgtttacttt cataggcaaa 3909 cattattatt ttatttattc ccaaatggtg caagtatttt agagtatgcc acatagtttt 3969 ctatatgcca gcagtctttt tcaaaaatac gtatacattc cacttcagtc cccctcatac 4029 tgtaaatttg tagacaacat gcttgttaca ttgctctctt cctgcaatac agtccttatt 4089 tcccctccat ccatcttgaa agtattcctt taatttctcc agtaacacta tgggtttgcc 4149 atttcgggca tcaatgacat tcagggatgt ggccatagac ttctcgcagc aggagtggga 4209 atgtctcgac catgttcaga agaccttgta ttgggatgtg atgatggaga actgtagtaa 4269 cttggtatgt tttctgcctc agacaattta ggataacttt gaatctgctc tctaggatga 4329 tttttcattg tgatttttag ggctgtcttt caagagacta gttaaatttc ttttcccttt 4389 tccccaaaga agtggtttgg gctttgttgg gtaggaagtg acagcttcac tagacatact 4449 catcttccct gtccctcagt gatgttcaaa cttttctctg gtcatagtta cagttgtctt 4509 tcttctttta taaggaaggg ctagattagg attcagcagc ctatattata taaccattgt 4569 aaaaggatcc aggtttccta tttctttatg ctccgaatta ctgtggatac tccattatag 4629 catctgatcc acttgcagat taccttgaca taggatcctg aattgctcta attatcaaaa 4689 gaacctttat aatgtatata gctttggatt agataaattg aattcattta aaactgaagc 4749 aaacacattc tatttcctaa gcaaatttta acttattcgt ggttgaaagt tgtggtttaa 4809 agttgtcatc tataaacatt acattttaaa tggaatgaat atcctataaa tatcttttct 4869 tgtatactct taacaaaaca acaatatcaa taataacctt agtagtgaac actgtgtcta 4929 ttaaaggtag tgttctaagc atttcacata tatgtctcaa ccaatttaat ccttattaaa 4989 ttcgacaatc ttattatatc ctcattttcc agttgagaat attaaagccc agtggattta 5049 aatgacttgc tgaaggtcat gcacagctgg gaggtggtaa aggcaggaat tgataccagg 5109 ctctagagtc tgtattttca accatggtat tatgtgtact ctcagg 5155 <210> 13 <211> 5344 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (113)..(2017) <400> 13 ctccacatcg cggctccggc acctgaaggg acgcgggcgg gcgcgggcag ctccgaccgg 60 cggcggcggg gcgggacagg cagcccggcg gcctccgatg gccccgccgt ga gag gcc 118 Glu Ala 1 gga ccc gcg gcg ggg acc agc agc ggt cta gag gag tcc cag gag cag 166 Gly Pro Ala Ala Gly Thr Ser Ser Gly Leu Glu Glu Ser Gln Glu Gln 5 10 15 cca gga cag gcg gaa gca gtg gct gcc atg gag gag gac aag ctc tta 214 Pro Gly Gln Ala Glu Ala Val Ala Ala Met Glu Glu Asp Lys Leu Leu 20 25 30 tct gca gtg cct gag gaa ggc gat gcc acc cgt gac ccc ggt cca gag 262 Ser Ala Val Pro Glu Glu Gly Asp Ala Thr Arg Asp Pro Gly Pro Glu 35 40 45 50 cct gaa gag gag cca ggg gtc cgg aat ggg atg gcc agt gag ggc ctg 310 Pro Glu Glu Glu Pro Gly Val Arg Asn Gly Met Ala Ser Glu Gly Leu 55 60 65 aac agc agc ctc tgc agc cca ggg cac gag cga agg ggc acc cca gcg 358 Asn Ser Ser Leu Cys Ser Pro Gly His Glu Arg Arg Gly Thr Pro Ala 70 75 80 gac act gag gaa ccc acg aag gac cca gat gtg gcc ttc cat ggc ctc 406 Asp Thr Glu Glu Pro Thr Lys Asp Pro Asp Val Ala Phe His Gly Leu 85 90 95 agc ctt ggc ctc tct ctc acc aat ggc cta gcc ctg ggg cca gac ttg 454 Ser Leu Gly Leu Ser Leu Thr Asn Gly Leu Ala Leu Gly Pro Asp Leu 100 105 110 aac att ctg gaa gat tca gcg gag tcc agg ccc tgg agg gct ggc gtg 502 Asn Ile Leu Glu Asp Ser Ala Glu Ser Arg Pro Trp Arg Ala Gly Val 115 120 125 130 ctg gca gag ggg gac aat gct tcc agg agc ctc tac cca gat gct gag 550 Leu Ala Glu Gly Asp Asn Ala Ser Arg Ser Leu Tyr Pro Asp Ala Glu 135 140 145 gac cct cag ctg ggg ttg gat ggt ccc ggg gag cca gat gtg cgg gat 598 Asp Pro Gln Leu Gly Leu Asp Gly Pro Gly Glu Pro Asp Val Arg Asp 150 155 160 ggc ttc agc gcc acg ttt gag aag att ctg gag tca gag ctg ctg cgg 646 Gly Phe Ser Ala Thr Phe Glu Lys Ile Leu Glu Ser Glu Leu Leu Arg 165 170 175 ggc acc cag tac agc agc ctc gac tcc cta gac ggg ctg agc ctc acg 694 Gly Thr Gln Tyr Ser Ser Leu Asp Ser Leu Asp Gly Leu Ser Leu Thr 180 185 190 gat gag agc gac agc tgc gtc agc ttc gag gcc ccc ctc aca ccc ctc 742 Asp Glu Ser Asp Ser Cys Val Ser Phe Glu Ala Pro Leu Thr Pro Leu 195 200 205 210 atc cag cag cgg gcc cgt gac agc cct gag cca ggg gct ggg ttg ggc 790 Ile Gln Gln Arg Ala Arg Asp Ser Pro Glu Pro Gly Ala Gly Leu Gly 215 220 225 att ggg gac atg gcg ttt gag ggg gac atg ggg gca gct ggt ggt gat 838 Ile Gly Asp Met Ala Phe Glu Gly Asp Met Gly Ala Ala Gly Gly Asp 230 235 240 ggg gag ctg ggc agc ccc ctg cgg cgc tcc atc tcc agc agc cgc tct 886 Gly Glu Leu Gly Ser Pro Leu Arg Arg Ser Ile Ser Ser Ser Arg Ser 245 250 255 gag aat gtc ctg agc cgc ctg tct ctc atg gcc atg ccc aat gga ttc 934 Glu Asn Val Leu Ser Arg Leu Ser Leu Met Ala Met Pro Asn Gly Phe 260 265 270 cat gaa gat ggc cct cag ggc cca ggg ggg gat gag gat gat gat gag 982 His Glu Asp Gly Pro Gln Gly Pro Gly Gly Asp Glu Asp Asp Asp Glu 275 280 285 290 gag gac acg gac aag ttg ctg aac tca gcc agt gac ccc agc ctg aag 1030 Glu Asp Thr Asp Lys Leu Leu Asn Ser Ala Ser Asp Pro Ser Leu Lys 295 300 305 gat ggc ctg tca gac tca gac tct gag ctc agc agc tcg gag ggg ttg 1078 Asp Gly Leu Ser Asp Ser Asp Ser Glu Leu Ser Ser Ser Glu Gly Leu 310 315 320 gag cct ggt agt gca gac cct ctg gcc aac ggg tgc cag ggg gtc agt 1126 Glu Pro Gly Ser Ala Asp Pro Leu Ala Asn Gly Cys Gln Gly Val Ser 325 330 335 gaa gct gct cat cgg ctg gca cgc cgt ctc tac cac ctc gag ggc ttc 1174 Glu Ala Ala His Arg Leu Ala Arg Arg Leu Tyr His Leu Glu Gly Phe 340 345 350 cag cgc tgt gat gtg gcc cgg cag ctg ggc aag aac aac gag ttt agc 1222 Gln Arg Cys Asp Val Ala Arg Gln Leu Gly Lys Asn Asn Glu Phe Ser 355 360 365 370 agg ctg gtg gcc ggg gag tac ctc agt ttc ttc gac ttc tcg ggc ttg 1270 Arg Leu Val Ala Gly Glu Tyr Leu Ser Phe Phe Asp Phe Ser Gly Leu 375 380 385 act ctg gac gga gca ctc aga aca ttc ttg aag gcc ttc ccg ctg atg 1318 Thr Leu Asp Gly Ala Leu Arg Thr Phe Leu Lys Ala Phe Pro Leu Met 390 395 400 ggg gag aca caa gag cgt gag cgg gtc ctc aca cac ttc tcc cgc cgg 1366 Gly Glu Thr Gln Glu Arg Glu Arg Val Leu Thr His Phe Ser Arg Arg 405 410 415 tac tgc cag tgc aac cct gat gac agc act tcg gaa gat ggg atc cac 1414 Tyr Cys Gln Cys Asn Pro Asp Asp Ser Thr Ser Glu Asp Gly Ile His 420 425 430 acg ctc acc tgt gcc ctg atg ctg ctc aac acg gac ctg cac ggc cac 1462 Thr Leu Thr Cys Ala Leu Met Leu Leu Asn Thr Asp Leu His Gly His 435 440 445 450 aac att ggc aaa aag atg tcc tgt cag caa ttc att gcc aac ttg gac 1510 Asn Ile Gly Lys Lys Met Ser Cys Gln Gln Phe Ile Ala Asn Leu Asp 455 460 465 cag ctg aat gat ggc caa gac ttt gcc aaa gac ctg ctg aag acc ctt 1558 Gln Leu Asn Asp Gly Gln Asp Phe Ala Lys Asp Leu Leu Lys Thr Leu 470 475 480 tac aac tcc atc aag aat gaa aag ctg gaa tgg gcc att gat gag gat 1606 Tyr Asn Ser Ile Lys Asn Glu Lys Leu Glu Trp Ala Ile Asp Glu Asp 485 490 495 gag ctg agg aaa tcc ctg tct gag ctg gtg gat gac aag ttc ggg aca 1654 Glu Leu Arg Lys Ser Leu Ser Glu Leu Val Asp Asp Lys Phe Gly Thr 500 505 510 ggc acg aag aag gtg acg cga atc ctg gat ggt ggc aac ccc ttc ctg 1702 Gly Thr Lys Lys Val Thr Arg Ile Leu Asp Gly Gly Asn Pro Phe Leu 515 520 525 530 gat gtc cca cag gcg ctc agt gcc acc acc tac aag cac ggc gtc ctg 1750 Asp Val Pro Gln Ala Leu Ser Ala Thr Thr Tyr Lys His Gly Val Leu 535 540 545 acc cgg aag act cac gct gac atg gat ggc aag agg acg ccc cgt ggg 1798 Thr Arg Lys Thr His Ala Asp Met Asp Gly Lys Arg Thr Pro Arg Gly 550 555 560 agg cgt ggc tgg aag aaa ttc tac gca gtg ctc aaa ggg acc atc ctg 1846 Arg Arg Gly Trp Lys Lys Phe Tyr Ala Val Leu Lys Gly Thr Ile Leu 565 570 575 tac ctg cag aag gat gag tac agg cct gac aaa gct cta tcg gag ggt 1894 Tyr Leu Gln Lys Asp Glu Tyr Arg Pro Asp Lys Ala Leu Ser Glu Gly 580 585 590 gac ctg aag aac gcc att cgc gtg cat cac gct ctg gcc acc agg gcc 1942 Asp Leu Lys Asn Ala Ile Arg Val His His Ala Leu Ala Thr Arg Ala 595 600 605 610 tct gac tac agc aag aag tcc aac gtg ctg aag ctt aag aca gcc gac 1990 Ser Asp Tyr Ser Lys Lys Ser Asn Val Leu Lys Leu Lys Thr Ala Asp 615 620 625 tgg agg gta ttc ctc ttc cag gca ccg tgagtaggag ctggagccct 2037 Trp Arg Val Phe Leu Phe Gln Ala Pro 630 635 tcactcccac ctggggccca gggccacagt gacccggcac acaacccctc tccttcccgt 2097 gagtcagcaa cagagcatgt gtatccacat gacacagacc gacagctggg tccctccaaa 2157 gcagtggttc ccaatgtgtg gttcccctca gcatcatttg cagtctctct ggccccacct 2217 tagacctact gaacccaaaa ctctgggatg gctccagcaa ctgtgtttaa caagccctgc 2277 aggggctgct gagtgcgctg gagtctgcaa tgtggggcag gtggcatctt tacgaatcat 2337 ccttcacttt aagtgtggga aagatgcacc ctccaggtaa cctgtaaggc tgtcctacca 2397 cctctcgtcc tcctgtgact tgagattggg gtgcacatgt cacatgagct tgcaaggagg 2457 caggctagtg ggtgaggcct caggatcaca gtgccagtgc tgggcaggca gcgggggagg 2517 gcaggagggc tgtgggggtc acccagttgc tattgcctct gatgatcccc agtccacagt 2577 cactcccacc tattcactcc agggccacta gctgtggacc tgggaagttt gatcttcaca 2637 tgagaattcg ggtgtgcctg gaagctggga cagaaaggga gctccgtgca tagctctggc 2697 caggcccatc cagcccccat gtgtcctccc tctccccttt atccacccat ctagaggtac 2757 tggtgccttc tcagtgccag gcccagtgct gggtacggga tgctgagtag gggacaggga 2817 gtcctgtgtg agaggccggc accctctccc cctcctgtcc ccaggagcaa ggaagaaatg 2877 ctgtcctgga tcctcaggat caacctggtg gcagccatct tctctgcccc ggccttccca 2937 gccgctgtca gctccatgaa gaagttctgt cggcccctgc tgccctcctg caccacccgc 2997 ctctgccagg aggagcaact gcggtctcat gagaataagt tgaggcagct gactgcggag 3057 ctggccgaac acaggtgtca cccagtcgag aggggcatca agtccaagga ggccgaggag 3117 taccggttga aggagcacta tctcaccttc gagaaaagcc gttatgagac ctatatccac 3177 ctcctggcta tgaaaatcaa agtgggctca gatgatctgg agcggattga ggcccggctg 3237 gccactctgg aaggggatga cccttctctc cggaagacac attcaagccc tgccctcagc 3297 cagggccatg tgactggcag caaaaccaca aaggatgcca ctgggcctga tacttagctg 3357 acatggattt gcagacccca gggtgggcag atgtctccag tggggtcagt gagcacaatt 3417 ccagccaggg gccacttgga ccaagctcca gtcagttgat gggcagctag aggggtgcag 3477 aaagcctgtg ggcccaggag atggagatgc cgtttgtggc gttgatctcc ttgcgtcctt 3537 gggcatctcc gggcatcaga ccctctccct ggcccttgtt ttcctctcca ccatggagcc 3597 tcattttgta ggccagttgt gtgcatgctc tagacaccac ctcgctggag aagctggaag 3657 ggctgttgtc ttcccaggtc tttctcttct catcaagctc ctctcctcat cttttttgtg 3717 tgtgagggca ggtcttgact ctaggtctca gctggaaccc caccctttct cctcctcctt 3777 cctctgagtt gaccagcagc aggtctgccg accaccagca ccatcctctc ctcccagcag 3837 cctccagaac catgcccagg tctcctgcct cacatcacaa taatctggga cccaggcttg 3897 tgccctttca gtgtaaagct gactccatca catgtgcatc cacttctttt catccattga 3957 gatcacactg cctccttttt atacagacac aaatatacat ctataagaat aatatataca 4017 taaggaaccc ctgaaagatg gttttggaac tggaatcagt tagaggatga aatcagataa 4077 aggaaaagcc tattttggag cttcccctgt taggaaggat ggctgcacct ggccccctgg 4137 cattcctgac gctctaggag ggaaggggga ggcagtgctg gcctcccttg ccctgttttt 4197 ccctcttcca gctgacctgt gacttatact gctcttaccg atgatacttt tggaaaaaat 4257 agagcgtgta tgcaccgccc cgtttgtccc atggatatcc tggggtgtga gtcggatggg 4317 accacggccc tgtttatatt tgggtcttta tgttggtgct gccaggtctc tgagctccag 4377 aggtggcctc ttggacagat ctactgctat aggaataaaa gacactctgt ctcgcaaatg 4437 gctgcttgtc aacaagccca aagatgcttg tcggaggacg gttatggaag cccttaattc 4497 ttggttgtgg gaaaaggtgg aatgacaagt tattgattgt ttttctgtcg ctatttcttt 4557 catttgtcta gtgaatcaga aaggcttagc caaggccaca tctgggaaga gtggagaaat 4617 ttgccacttg acgatcacgg attagctagc acctttaagc cctgcatttc tccaactgac 4677 aagtgggtgg gggtgatggc acattcagtg tggctatgaa gagcgaatcc tctctattgt 4737 ttaaatagat tactgtagtt tggccaggaa tttggcgtca gtggtaacac acttagttaa 4797 taaaataagc caggcttgca actaagtatc taactttaca ggcccactca catttgaggc 4857 aaggggctat tgagtatgtg gagagatgta gtgatttaaa ttcagattat ttaagttgga 4917 tcagctgaag tgtgttttag acccaaacca tctggcccct tcgttttgct cagaggaagt 4977 aaatgttcac ttaaatgaaa ttgaaaacgc catgtggcac cacaaaagag ctctctgtac 5037 tttccccatg ctgcctcaaa agttctgtga gtttcggggt cagtgtccca cccttcactt 5097 cccgagggcg ggtgagtgga gagcagagcc aggagctctg gcagctgtgg acagatgtgc 5157 ttcctgagca tgggttgtgc ctcccatcag taaaaaaatg tttagttcac ttccttaatt 5217 gtataattat ttatttgtaa attatataca tgtactactg tactaaaata ttatgtacat 5277 tataaaacat acacaaaaat agaaatttaa aaaagatgag atgaaaataa atctaagtca 5337 aagttct 5344 <210> 14 <211> 5432 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1188) <400> 14 cag gtc tcc ctg gac aag cca ctg tcc tca gct gcc cac ttg gac gat 48 Gln Val Ser Leu Asp Lys Pro Leu Ser Ser Ala Ala His Leu Asp Asp 1 5 10 15 gca gcc aag atg cct tct gca tcc agt ggt gaa gaa gca gac gct ggc 96 Ala Ala Lys Met Pro Ser Ala Ser Ser Gly Glu Glu Ala Asp Ala Gly 20 25 30 agc ctc ctg ccc acc acc aat gag ctc tcc caa gcc tta gct ggg gct 144 Ser Leu Leu Pro Thr Thr Asn Glu Leu Ser Gln Ala Leu Ala Gly Ala 35 40 45 gac tcc ctg gac agt cct ccc aga cct ctg gag aga tcc gtg ggc cag 192 Asp Ser Leu Asp Ser Pro Pro Arg Pro Leu Glu Arg Ser Val Gly Gln 50 55 60 ctc ccc agc ccc cca ctg ctg ccc act ccg cca ccc aag gca agc tcc 240 Leu Pro Ser Pro Pro Leu Leu Pro Thr Pro Pro Pro Lys Ala Ser Ser 65 70 75 80 aaa acc aca aaa aat gtc aca ggc caa gcc aca ctc ttc caa gcc tcc 288 Lys Thr Thr Lys Asn Val Thr Gly Gln Ala Thr Leu Phe Gln Ala Ser 85 90 95 agc atg aag agt gcc gac cct tcc ctc cgg ggc cag ctc tcc aca ccc 336 Ser Met Lys Ser Ala Asp Pro Ser Leu Arg Gly Gln Leu Ser Thr Pro 100 105 110 acg ggg tct ccg cat ctc acc acg gtc cac cgg cct ctt ccc cca agc 384 Thr Gly Ser Pro His Leu Thr Thr Val His Arg Pro Leu Pro Pro Ser 115 120 125 cgc gtc att gag gag ctg cac agg gcg ctg gcc acg aag cac cgc cag 432 Arg Val Ile Glu Glu Leu His Arg Ala Leu Ala Thr Lys His Arg Gln 130 135 140 gac agt ttt caa gga aga gaa agt aaa ggg tct cca aag aag cgg ctg 480 Asp Ser Phe Gln Gly Arg Glu Ser Lys Gly Ser Pro Lys Lys Arg Leu 145 150 155 160 gat gtc cgt ctg tcg aga acg tcc agc gtg gag cgg ggc aag gag agg 528 Asp Val Arg Leu Ser Arg Thr Ser Ser Val Glu Arg Gly Lys Glu Arg 165 170 175 gag gag gct tgg agc ttt gac ggg gca ttg gag aac aag cga act gcc 576 Glu Glu Ala Trp Ser Phe Asp Gly Ala Leu Glu Asn Lys Arg Thr Ala 180 185 190 gct aag gaa tct gag gag aac aag gag aac ctg atc ata aat tct gaa 624 Ala Lys Glu Ser Glu Glu Asn Lys Glu Asn Leu Ile Ile Asn Ser Glu 195 200 205 ctc aaa gac gac ttg ctt ttg tat cag gac gag gag gcg ctg aac gac 672 Leu Lys Asp Asp Leu Leu Leu Tyr Gln Asp Glu Glu Ala Leu Asn Asp 210 215 220 tcc att att tct gga aca ctg cca cgg aaa tgc aag aag gag ctc ctg 720 Ser Ile Ile Ser Gly Thr Leu Pro Arg Lys Cys Lys Lys Glu Leu Leu 225 230 235 240 gcc gtg aag cta agg aac cgg cca agc aaa cag gaa cta gaa gac cgg 768 Ala Val Lys Leu Arg Asn Arg Pro Ser Lys Gln Glu Leu Glu Asp Arg 245 250 255 aac att ttc ccc aga agg act gat gaa gaa aga cag gag atc cgg cag 816 Asn Ile Phe Pro Arg Arg Thr Asp Glu Glu Arg Gln Glu Ile Arg Gln 260 265 270 cag atc gag atg aag ctt tcc aaa cgg ctg agc caa aga cct gcc gtg 864 Gln Ile Glu Met Lys Leu Ser Lys Arg Leu Ser Gln Arg Pro Ala Val 275 280 285 gaa gag ctg gag aga aga aat atc ttg aaa caa agg aat gat cag aca 912 Glu Glu Leu Glu Arg Arg Asn Ile Leu Lys Gln Arg Asn Asp Gln Thr 290 295 300 gag cag gaa gaa aga aga gaa atc aag caa aga ttg aca aga aag ctt 960 Glu Gln Glu Glu Arg Arg Glu Ile Lys Gln Arg Leu Thr Arg Lys Leu 305 310 315 320 aat cag aga ccc act gtt gat gaa tta aga gac aga aaa att ctg ata 1008 Asn Gln Arg Pro Thr Val Asp Glu Leu Arg Asp Arg Lys Ile Leu Ile 325 330 335 cga ttc agt gat tac gtg gaa gta gca aaa gcg cag gac tat gac agg 1056 Arg Phe Ser Asp Tyr Val Glu Val Ala Lys Ala Gln Asp Tyr Asp Arg 340 345 350 agg gca gac aaa ccc tgg acg aga ctg tca gca gca gat aag gca gca 1104 Arg Ala Asp Lys Pro Trp Thr Arg Leu Ser Ala Ala Asp Lys Ala Ala 355 360 365 att cgt aaa gaa tta aat gag tac aaa agt aat gaa atg gag gta cat 1152 Ile Arg Lys Glu Leu Asn Glu Tyr Lys Ser Asn Glu Met Glu Val His 370 375 380 gca tca agc aag cac ttg aca aga ttc cac agg cca tagagatttt 1198 Ala Ser Ser Lys His Leu Thr Arg Phe His Arg Pro 385 390 395 cttctgagaa gaatttgtgt ttaatttttt gataccaaca ctgaacattc atcagggaac 1258 tttcctgaag ttcagctcaa gactacccta cctgctgtgt ttgtgagaag agtaggatca 1318 cacacacagg tgcaatcttg accacactta cctgcaagag gagtaaccag aggacacact 1378 tccttccttc tttggtgtct gaggagtgtg aactgttggg gtcagttaag acccaacata 1438 actctatcag aagaaaactg ttgtttgcct ttcaaccttg ttttacagtt ctgcagtgta 1498 atggaggacg ggcaacgtgc atgtgcaggc tcaccactcc caggcctctg acatgaggga 1558 catgtgacag tgtcattcag tattatgttc aaaagacatt tttatcctga tcataattaa 1618 tttgaaaact ctttaagttc atgttataca agatgattta ctgtattata cttttccttt 1678 tttatataat gtctaacaaa aaatacagct gcaacatttt gattcctgtt aattttgttc 1738 tttaattaaa tgactactta ttgcaggaaa ttaacccagg ctttacattt tcttgtggtt 1798 gggatgagtg gtactttaga acagggatct gtgaaacaag tcaattttta cttgtgaacg 1858 atcagaatcc aaacacatga atgagaattc caacttttta tgtgtttggt ttgtgcctta 1918 gaaaatcaaa ttgagtgcct ttaaccaaga aataagcaat aatttgttga aaaattctat 1978 caaaatgaaa agtatgcctc tttagagtat ttttaagctc acctctgcaa acactgttaa 2038 agaaaggaaa tttaccccag cacaaaggtg aaaatcttgg cacaaagggg gaaactaaca 2098 atacatgttc cctgaaaaat atttttaatt ggctttcaaa taagtgtcct tacagagatg 2158 agccttccct cctccttccc tcctggtata ctggtgaggc aggaagcaca gtaacttgga 2218 gcatgacttt cagagcttgc agaacttgtg cacaaatcca agctctgtgc tattcaacaa 2278 gttacttgtt ttttctatag tatggtcata tctctctcac acaacattgc tgtagtatct 2338 aaataagaca aagtagctaa agtgctggca cattgctgag gacgttctgg gaatccaata 2398 aatgttagct actgatatgg ttgccaggta gcacctggag caactgagtg tcctctatga 2458 cttcttgcca catatgctac ctcattgctt tccactattt ttccttttct acttaagact 2518 gctactgggt cagacgccca cagaaactgc caagtcttta tgttagcact ttgtccaaag 2578 tgacttatga tcagtcctag agactagcaa aacacactat tcattgaatt atagtttttt 2638 ttaataagaa attgttatgg tagaaaaatt ccagctctac ctcttagctg ctctgtaacc 2698 ttctgtgaat cagttgactt ctctgagcct caatttgttt gtgaaatgta tctaaatcct 2758 ttctaattag aagtcagtta aatttaaagg atttgatata tatatatata tacattatat 2818 attttctgtt attcataacc cattatttgt agccaaaact ttacctcttt tctatcttaa 2878 gcaacatatt agaagctctc tgtatttaat attcaattta aaatattaat gggagcccaa 2938 attatgtaaa actaagattt caatttccct cacatagaaa tattaatata tttactatga 2998 aacagaaaag gaaaaggtgc tactgtttag aaaccacctt ggcccccaaa gtacaaaaga 3058 tcagtactgc ttaacaaaag aaccaggcag atcctatagt tagaaatgac ctggttagat 3118 gggacatata tttagttttt tccccaagtc ccataactag tggataataa aactaaaaag 3178 gtaaagtgca ggataaccaa aggagggttt ggactggttc agactcaaag gttctaagat 3238 atcctaaaac cagcagacat attcacttaa atcaaaattt gtggcaatag catctaactt 3298 ctaccattgt gtttttatta tgcacaaact attactctat acttacatat ttcatgttct 3358 tatcaggtat tataagggtt aagagataaa ctaaaattga atcaagtata tttactctcc 3418 acctgcacat cacaactatc aagttagagg aataaaatta aaaagcaatt cacaagtcat 3478 attacactga tgacatacat gtatatgtac acgcatttgc atatatttat aatttgaaga 3538 gaaagtttat atacttaaca gccaacagat ttagaaaaaa ctatttgtcc tactgaataa 3598 cagtatatat gaattatcag aattcttcat tactagtatt caataatgag ctttttatgc 3658 aataaattta caaatcattt gcccctattt tcagaaaaaa ttattaaagc aaccatgaat 3718 atttaaatca taagttctgt ttttaaggag ttcaaaacat ttttacaagc atgttagtaa 3778 tttagtgaga ggaaattaaa tatcttctag aaacatctag taacttttaa gctaatgtaa 3838 tagaggaaat actacattat atgactttgt aaaaagtatt tctaaaaaaa tttaaagggg 3898 gctgggcatg gtggctcatg cctgtaatcc cagcactttg ggaggccgag atgagtggat 3958 tgctttagtc caggagttcg acaccagcct gggcaacata gcgaaactcc atctctacaa 4018 aacaaaaaat tagctgggca tggtggtatg cgcctgtagt cccagctact agggaggctg 4078 aggtggcagg atcacttgag cccgggaggt taaggccata gtgagccgtg attgcaccac 4138 tgcactccaa ccagggcaac agagcaagac cctgtctcaa aaaatataaa aataaaataa 4198 agagactttg aaatcatatc acctaagtaa ttttttgaca attgaaatgg tggtgggagc 4258 ggggaggaag aacctaacat caagacatcc accttgtgga aagatatggt aattacaggc 4318 ctacatttat tatacattgg aagtaaagtc aaagttttta gctatgtacc tacagtcctt 4378 caacaacaaa ttcaagctca gaaatgcaaa atcctaattg tactattaaa actgctatta 4438 ctatatgctt ccgataccca tttgtctagt ttttttccag agaccttttt ctccattttt 4498 catatgaaaa catctcagaa gatattcgta agcaagtgaa catatgaaac tgaatatatg 4558 aaaaatattt tcaaaaagta gatttctata aatcccattt gcttatttag ctgcaaattt 4618 atttacagtg atgatactag gaacatacta ctagttcaaa caaaaaatgt ttgttcgaat 4678 gaacaacaga aagtactggt tagcagttcc atagttctat gaaaatagag cagtattttt 4738 aaagtaataa aaattttctt aaaaaacctt ttcaaagttt ttaatctcaa ctgtaaatct 4798 taaagatata aatggggaaa ttctaaaaat tcagttttct tactaagcaa tgggaggaaa 4858 gaaatctgga tatatggtac atatgacaat aatttaatgt ttcaagttgc agacatgtta 4918 catatgtgta ttattccttt ctaaatgcag tttattatcc cttctcaaaa atacatacac 4978 tgaatgtatt actacaattc aggtgtgttc cctaaaagac tggtctatac caccagtcca 5038 ttctctgctt tccagatagc ctacttctta attataatgg tgacacctga tgtggcagaa 5098 agcacaatct ccagaaccac ctatcatctt gcttcaattt ttacattcca agttagattt 5158 gtttgttgat attatttgct ggtattttat tttgctcaaa attctacttg tttattcata 5218 gcatatatga ttcttccata ctttaagttt taattagata agaaacttat acactaactg 5278 tatgtggttt aactgttaat aggtggtaac agaatggtta aagaactaac tccagcaact 5338 gtgaagctca acactaggca ctgaactcag agttggcaga atttgtcact gtagactaca 5398 aatttcatgt tgaattaaat gctgtatgaa aacc 5432 <210> 15 <211> 3727 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1522)..(3444) <400> 15 gtgaatctcc agagccacac ccacttcaag ataatgggtc atttttgtgg ttttccatga 60 tgtctcaaag catgggtggt gataacctca gtagcttaga tactaatgaa gcagaaattg 120 aaccagaaaa catgagagaa aagttcttca gaagcttagc aaggttactg gaaaacaaaa 180 gtaataatac taagatattt tctaaagcaa agtactgtca gttgataaag gaagtgaaag 240 aagctaaagc taaggcgaaa aaggaatcag ttgactaccg tcgcttggct agatttgatg 300 ttatccttgt acaaggaaat gagaagctaa ttgaggctgt aaatggggaa acagataaaa 360 tacggtatta cttacacagt gaggacttat ttgacattct gcataataca catctcagca 420 ttggacatgg tggacgtact cgcatggaga aagagttaca agcgaaatac aagaacatca 480 caaaagaagt tataatgctg tatctgaccc tctgtaaacc atgccaacag aaaaattcaa 540 aactcaagaa ggttctaaca tcaaaatcaa ttaaggaagt tagttcaaga tgccaagtag 600 atcttataga catgcagttg aatcctgatg gggagtacag atttattttg cattatcaag 660 atctctgtac aaagttaact tttttgcggt cattaaagtc taaaaggcct acggaagttg 720 cacatgctct tttagatata tttacaatta ttggagcacc cagtgtccta caatctgaca 780 atgggaggga attttcaagc caggttgtca gtgaactcag taatatttgg ccagaattga 840 aaattgtcca tgggaagtct cagacctgcc aaagccagag ttctgcagaa caaactgagg 900 atatccgaaa gaggattttc tcctggatgc aaactaacaa ctcatcacac tggactgaat 960 ttttgtggtt cattcagatg tcccaaaatc agccctatca cagaagcatg caacagactc 1020 catgtgaaag tgcatttagc tctgaagcta aactgggctt gtcccattct cagctaactg 1080 aagaacttgt tgccagcttg catacagaaa atgaattaga tcaggctgac aaagagttag 1140 aaaatacttt aagagcccag tatgaagaaa acattgagac tggaacagac agtagtgata 1200 ttgaagagaa tctttctgtc actcctaagg tggctgaaaa aagccctcct gagagcagac 1260 taagattttt atcctgtgta gtttgtgaaa aagaatgcac aggtgttaat agttgtatat 1320 catgtgatgg aaatatccat gcaatttgtg gagtgccctc tcaacatggg actgagggct 1380 gtggtcggca aataacttgt agcctttgct atgaaaccag cacaatgaag aggaaacatg 1440 atgagattca aagaagtttg cctgttaaac cttccaaaat gctaaagcca tcagggacac 1500 cattttcacc agacaaagta g gag act gga tgg cga aac aag ctt cac tgg 1551 Glu Thr Gly Trp Arg Asn Lys Leu His Trp 1 5 10 act ttt ttt gtc aag aaa aga cat gcc ttt tct gaa cac agt agt agt 1599 Thr Phe Phe Val Lys Lys Arg His Ala Phe Ser Glu His Ser Ser Ser 15 20 25 aat aaa aga aat gtt aac aat aga agt tat cct gaa gaa ggg aaa acc 1647 Asn Lys Arg Asn Val Asn Asn Arg Ser Tyr Pro Glu Glu Gly Lys Thr 30 35 40 aaa aga gtt cat gct agt ttc act cgg aaa tat gat cct tca tat att 1695 Lys Arg Val His Ala Ser Phe Thr Arg Lys Tyr Asp Pro Ser Tyr Ile 45 50 55 gag ttt ggt ttt gta gct gta att gat ggt gaa gta cta aaa cca cag 1743 Glu Phe Gly Phe Val Ala Val Ile Asp Gly Glu Val Leu Lys Pro Gln 60 65 70 tgt att att tgt gga gat gta ctg gct aat gaa gca atg aaa cca tca 1791 Cys Ile Ile Cys Gly Asp Val Leu Ala Asn Glu Ala Met Lys Pro Ser 75 80 85 90 aaa ctt aag cga cat tta tat tca aaa cat aaa gaa ata agt tca caa 1839 Lys Leu Lys Arg His Leu Tyr Ser Lys His Lys Glu Ile Ser Ser Gln 95 100 105 cca aaa gaa ttc ttt gaa aga aag agt agt gaa ttg aaa agc caa cca 1887 Pro Lys Glu Phe Phe Glu Arg Lys Ser Ser Glu Leu Lys Ser Gln Pro 110 115 120 aag cag gtg ttc aac gtt tct cat ata aac att agt gct ttg cgg gct 1935 Lys Gln Val Phe Asn Val Ser His Ile Asn Ile Ser Ala Leu Arg Ala 125 130 135 tca tat aaa gta gca ctt ccg gtt gcc aag tct aaa aca cca tac aca 1983 Ser Tyr Lys Val Ala Leu Pro Val Ala Lys Ser Lys Thr Pro Tyr Thr 140 145 150 att gct gag aca cta gtg aaa gac tgc atc aaa gaa gtt tgc ttg gaa 2031 Ile Ala Glu Thr Leu Val Lys Asp Cys Ile Lys Glu Val Cys Leu Glu 155 160 165 170 atg ttg ggt gaa tct gca gca aag aag gta gct cag gta cca ctt tcc 2079 Met Leu Gly Glu Ser Ala Ala Lys Lys Val Ala Gln Val Pro Leu Ser 175 180 185 aat gac acc ata gct cga cgt att cag gaa ctg gct aat gat atg gaa 2127 Asn Asp Thr Ile Ala Arg Arg Ile Gln Glu Leu Ala Asn Asp Met Glu 190 195 200 gat caa ctc ata gaa caa ata aaa cta gca aag tat ttt tca ttg caa 2175 Asp Gln Leu Ile Glu Gln Ile Lys Leu Ala Lys Tyr Phe Ser Leu Gln 205 210 215 ctt gat gaa tgc aga gat att gct aac atg ata att ctt tta gtc tat 2223 Leu Asp Glu Cys Arg Asp Ile Ala Asn Met Ile Ile Leu Leu Val Tyr 220 225 230 gtg agg ttt gaa cat gat gat gat ata aag gaa gag ttc ttt ttt tca 2271 Val Arg Phe Glu His Asp Asp Asp Ile Lys Glu Glu Phe Phe Phe Ser 235 240 245 250 gcc tct ttg cct aca aac aca act agc tca gaa ctg tat gaa gct gta 2319 Ala Ser Leu Pro Thr Asn Thr Thr Ser Ser Glu Leu Tyr Glu Ala Val 255 260 265 aag aat tat att gtt aac aaa tgt ggt ttg gaa ttt aaa ttt tgt gta 2367 Lys Asn Tyr Ile Val Asn Lys Cys Gly Leu Glu Phe Lys Phe Cys Val 270 275 280 gga gta tgt tct gat ggt gca gct tca atg aca gga aaa cat tct gaa 2415 Gly Val Cys Ser Asp Gly Ala Ala Ser Met Thr Gly Lys His Ser Glu 285 290 295 gtg gta acc cag att aag gaa ctt gcg cca gaa tgt aaa aca aca cat 2463 Val Val Thr Gln Ile Lys Glu Leu Ala Pro Glu Cys Lys Thr Thr His 300 305 310 tgc ttc att cat cga gaa agt ctt gcc atg aaa aaa ata tca gct gaa 2511 Cys Phe Ile His Arg Glu Ser Leu Ala Met Lys Lys Ile Ser Ala Glu 315 320 325 330 cta aat agt gta ctt aat gat ata gta aaa att gtg aat tat ata aaa 2559 Leu Asn Ser Val Leu Asn Asp Ile Val Lys Ile Val Asn Tyr Ile Lys 335 340 345 tct aat tca ttg aat tca aga tta ttc tct tta tta tgt gat aat atg 2607 Ser Asn Ser Leu Asn Ser Arg Leu Phe Ser Leu Leu Cys Asp Asn Met 350 355 360 gaa gct gat cat aag caa ctg tta ctg cat gct gag ata cgg tgg tta 2655 Glu Ala Asp His Lys Gln Leu Leu Leu His Ala Glu Ile Arg Trp Leu 365 370 375 tca cgg gga aaa gtt ctg tca aga atg ttt gaa ata cga aat gaa ctc 2703 Ser Arg Gly Lys Val Leu Ser Arg Met Phe Glu Ile Arg Asn Glu Leu 380 385 390 tta gtg ttt ctg caa ggc aag aaa ccc atg tgg tcc caa ctt ttt aaa 2751 Leu Val Phe Leu Gln Gly Lys Lys Pro Met Trp Ser Gln Leu Phe Lys 395 400 405 410 gat gtg aat tgg aca gcc aga ctt gct tat ttg tct gat atc ttc agt 2799 Asp Val Asn Trp Thr Ala Arg Leu Ala Tyr Leu Ser Asp Ile Phe Ser 415 420 425 att ttt aat gat ctt aat gct tct atg caa ggg aag aat gca act tat 2847 Ile Phe Asn Asp Leu Asn Ala Ser Met Gln Gly Lys Asn Ala Thr Tyr 430 435 440 ttt tca atg gca gat aaa gtt gaa gga caa aaa cag aag tta gaa gct 2895 Phe Ser Met Ala Asp Lys Val Glu Gly Gln Lys Gln Lys Leu Glu Ala 445 450 455 tgg aaa aac aga att tct aca gat tgt tat gac atg ttt cat aat tta 2943 Trp Lys Asn Arg Ile Ser Thr Asp Cys Tyr Asp Met Phe His Asn Leu 460 465 470 aca aca att atc aat gaa gta ggt aat gat ctt gat att gca cat ctg 2991 Thr Thr Ile Ile Asn Glu Val Gly Asn Asp Leu Asp Ile Ala His Leu 475 480 485 490 cga aaa gtt atc agt gaa cat ctt aca aat ttg tta gaa tgt ttt gaa 3039 Arg Lys Val Ile Ser Glu His Leu Thr Asn Leu Leu Glu Cys Phe Glu 495 500 505 ttt tat ttt cca tca aaa gaa gat cca cgc ata gga aat ttg tgg atc 3087 Phe Tyr Phe Pro Ser Lys Glu Asp Pro Arg Ile Gly Asn Leu Trp Ile 510 515 520 caa aat cca ttt ctt tca tca aaa gat aac tta aat tta act gta act 3135 Gln Asn Pro Phe Leu Ser Ser Lys Asp Asn Leu Asn Leu Thr Val Thr 525 530 535 cta cag gat aag ttg ttg aag ctg gct acc gac gaa gga ttg aaa atc 3183 Leu Gln Asp Lys Leu Leu Lys Leu Ala Thr Asp Glu Gly Leu Lys Ile 540 545 550 agt ttt gaa aat aca gca tca ctt cct tca ttt tgg ata aaa gct aaa 3231 Ser Phe Glu Asn Thr Ala Ser Leu Pro Ser Phe Trp Ile Lys Ala Lys 555 560 565 570 aat gac tat cct gag ctt gct gag att gct tta aaa ttg ctg ctt ctt 3279 Asn Asp Tyr Pro Glu Leu Ala Glu Ile Ala Leu Lys Leu Leu Leu Leu 575 580 585 ttc ccc tca aca tac ctc tgt gag acc gga ttc tct act tta agt gtt 3327 Phe Pro Ser Thr Tyr Leu Cys Glu Thr Gly Phe Ser Thr Leu Ser Val 590 595 600 att aaa aca aaa cat aga aac agt tta aat ata cat tat ccc ctg agg 3375 Ile Lys Thr Lys His Arg Asn Ser Leu Asn Ile His Tyr Pro Leu Arg 605 610 615 gta gca ttg tca tca atc caa cct aga tta gac aaa tta aca agc aag 3423 Val Ala Leu Ser Ser Ile Gln Pro Arg Leu Asp Lys Leu Thr Ser Lys 620 625 630 aag caa gct cac tta tca cat taaaagcttt aaatattgat atgtaaggta 3474 Lys Gln Ala His Leu Ser His 635 640 ttggttcaaa gtatgcatat aagcattgag tgtgaggaat ttgctatttc actttaaact 3534 ttctgtctag ttacagttat ggaagtatga gaagttatga gtgaaacagc aattttctat 3594 ataaattgcc tatatgtata ttttcaatta agaatgtgta cagtttttat aattctattt 3654 ttcctcatat ttgtcgtatt tattaaaata taattttaaa tctgttgatt ctaatattaa 3714 aacatttgat ctt 3727 <210> 16 <211> 4070 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (528)..(3821) <400> 16 gccagctgct gcgcatgcgc cggccggggc cccgccccca tgcgccgcgc ggctccaggg 60 ccacgttcca gggtcgggtt tggtggattc ctcagtccct gccgccgcgg ggcgccctgg 120 gatagcggcg gggcctcctg gtgagcgcgc gccggggcgg cctccgggaa gtgggagacg 180 ctgcgggtcc tgggcccagg ccttgggatg ggcgggaagg cttggccgcg ccgggctgtg 240 ggcactgcag gaggcccctg tgcaggtgga gatcgccgcg gccctggcgg gactccttgc 300 tggctcttgg gcgcgctgat gcccatcatc tccctgagtt tctgagccct atctctcatg 360 tgtcagtggt caccgccgaa tccagacact ccggccctgt tccggaagag ccctgatatc 420 cgtggctcca tggtgctgtc tgtcgatacc atgcactcta gctctcaagg aggaaaggtt 480 ttgtggaagg gaatagagac ttggaataac agacctgtgc taattag aga cag gaa 536 Arg Gln Glu 1 aga tgg aac aag ggg agt gac cct tct cca ccc cca tat cct aat gtg 584 Arg Trp Asn Lys Gly Ser Asp Pro Ser Pro Pro Pro Tyr Pro Asn Val 5 10 15 ctc tct ctc tat cca gaa cag atc tcg gcc cct ttc caa aca ctc ctg 632 Leu Ser Leu Tyr Pro Glu Gln Ile Ser Ala Pro Phe Gln Thr Leu Leu 20 25 30 35 atg cct cat ttg cct ctc gcc tct ttt cga cca cca ttt tgg ggg ctg 680 Met Pro His Leu Pro Leu Ala Ser Phe Arg Pro Pro Phe Trp Gly Leu 40 45 50 agg cac tca cgg ggc ctc ccc agg ttt cac tcc gtt tct aca cag tcg 728 Arg His Ser Arg Gly Leu Pro Arg Phe His Ser Val Ser Thr Gln Ser 55 60 65 gag ccc cat gga tct ccc atc tcc cgg agg aac cgt gaa gcc aaa cag 776 Glu Pro His Gly Ser Pro Ile Ser Arg Arg Asn Arg Glu Ala Lys Gln 70 75 80 aag cgc ctg cga gag aag cag gcg act ctg gag gct gag ata gca ggg 824 Lys Arg Leu Arg Glu Lys Gln Ala Thr Leu Glu Ala Glu Ile Ala Gly 85 90 95 gag agc aag tca cct gca gaa tcc att aag gcc tgg agg cct aag gag 872 Glu Ser Lys Ser Pro Ala Glu Ser Ile Lys Ala Trp Arg Pro Lys Glu 100 105 110 115 tta gta ttg tat gaa atc cct acg aaa ccc ggt gaa aag aaa gat gtc 920 Leu Val Leu Tyr Glu Ile Pro Thr Lys Pro Gly Glu Lys Lys Asp Val 120 125 130 tct ggg ccc ctg cct cct gca tac agc ccc cga tat gtt gag gct gcc 968 Ser Gly Pro Leu Pro Pro Ala Tyr Ser Pro Arg Tyr Val Glu Ala Ala 135 140 145 tgg tac ccg tgg tgg gta cga gag ggc ttc ttc aaa cca gaa tat cag 1016 Trp Tyr Pro Trp Trp Val Arg Glu Gly Phe Phe Lys Pro Glu Tyr Gln 150 155 160 gcc cgg ctg ccc caa gct aca ggg gag acc ttt tcc atg tgt atc cca 1064 Ala Arg Leu Pro Gln Ala Thr Gly Glu Thr Phe Ser Met Cys Ile Pro 165 170 175 cct ccc aat gtc act ggc tcc ctg cac att ggc cac gca ctc acg gtg 1112 Pro Pro Asn Val Thr Gly Ser Leu His Ile Gly His Ala Leu Thr Val 180 185 190 195 gcc ata cag gat gcc ctc gtg cgc tgg cac cgg atg cgt ggg gat caa 1160 Ala Ile Gln Asp Ala Leu Val Arg Trp His Arg Met Arg Gly Asp Gln 200 205 210 gtg ctg tgg gtc cct ggt tca gat cat gca gga att gct aca caa gct 1208 Val Leu Trp Val Pro Gly Ser Asp His Ala Gly Ile Ala Thr Gln Ala 215 220 225 gtg gtg gag aaa caa ctg tgg aag gaa cgg gga gtg agg aga cat gag 1256 Val Val Glu Lys Gln Leu Trp Lys Glu Arg Gly Val Arg Arg His Glu 230 235 240 ctg agc cgg gag gcc ttc ctt agg gag gtg tgg cag tgg aag gag gcg 1304 Leu Ser Arg Glu Ala Phe Leu Arg Glu Val Trp Gln Trp Lys Glu Ala 245 250 255 aaa ggt gga gag atc tgt gag cag ctg cga gct ctg ggt gcc tcc ctg 1352 Lys Gly Gly Glu Ile Cys Glu Gln Leu Arg Ala Leu Gly Ala Ser Leu 260 265 270 275 gac tgg gat cga gag tgt ttt acc atg gat gtt ggc tcc tca gtg gct 1400 Asp Trp Asp Arg Glu Cys Phe Thr Met Asp Val Gly Ser Ser Val Ala 280 285 290 gtg act gaa gct ttt gtg cgg ctc tac aag gcg ggg ttg ctg tac cgg 1448 Val Thr Glu Ala Phe Val Arg Leu Tyr Lys Ala Gly Leu Leu Tyr Arg 295 300 305 aac cat cag ctt gtc aac tgg tca tgt gct tta aga tca gcc atc tcg 1496 Asn His Gln Leu Val Asn Trp Ser Cys Ala Leu Arg Ser Ala Ile Ser 310 315 320 gac att gag gtg gag aac cgg ccc ctg cct ggc cac aca cag ctt cga 1544 Asp Ile Glu Val Glu Asn Arg Pro Leu Pro Gly His Thr Gln Leu Arg 325 330 335 ctg cct ggc tgc ccc acc ccc gtg tct ttt ggc ctc cta ttt tct gtt 1592 Leu Pro Gly Cys Pro Thr Pro Val Ser Phe Gly Leu Leu Phe Ser Val 340 345 350 355 gcc ttc ccc gtg gat gga gag cct gat gca gag gtt gtg gta gga acc 1640 Ala Phe Pro Val Asp Gly Glu Pro Asp Ala Glu Val Val Val Gly Thr 360 365 370 aca agg cca gag acg ctg cct gga gat gtg gct gtg gcc gtt cat cca 1688 Thr Arg Pro Glu Thr Leu Pro Gly Asp Val Ala Val Ala Val His Pro 375 380 385 gac gac tcg cga tac aca cat cta cac ggg cga cag ctt cgt cac ccc 1736 Asp Asp Ser Arg Tyr Thr His Leu His Gly Arg Gln Leu Arg His Pro 390 395 400 ttg atg ggg cag cct ctt ccc ctc atc aca gac tat gct gtt cag cca 1784 Leu Met Gly Gln Pro Leu Pro Leu Ile Thr Asp Tyr Ala Val Gln Pro 405 410 415 cat gtg ggc acg ggg gca gtg aag gtg act cca gct cac agt cct gcc 1832 His Val Gly Thr Gly Ala Val Lys Val Thr Pro Ala His Ser Pro Ala 420 425 430 435 gat gct gag atg ggg gcc cga cat ggc ttg agc ccc ttg aat gtc att 1880 Asp Ala Glu Met Gly Ala Arg His Gly Leu Ser Pro Leu Asn Val Ile 440 445 450 gcg gag gat ggg acc atg acc tcc ctc tgc ggg gac tgg ctg cag ggt 1928 Ala Glu Asp Gly Thr Met Thr Ser Leu Cys Gly Asp Trp Leu Gln Gly 455 460 465 ctt cac cgg ttt gtg gcc cgg gaa aag ata atg tct gtg ctg agt gaa 1976 Leu His Arg Phe Val Ala Arg Glu Lys Ile Met Ser Val Leu Ser Glu 470 475 480 tgg ggc ctg ttc cgg ggc ctc cag aac cac ccc atg gta ctg ccc atc 2024 Trp Gly Leu Phe Arg Gly Leu Gln Asn His Pro Met Val Leu Pro Ile 485 490 495 tgc agc cgt tct ggg gat gtg ata gaa tac ctg ctg aag aac cag tgg 2072 Cys Ser Arg Ser Gly Asp Val Ile Glu Tyr Leu Leu Lys Asn Gln Trp 500 505 510 515 ttt gtc cgc tgc cag gaa atg ggg gcc cga gct gcc aag gct gtg gag 2120 Phe Val Arg Cys Gln Glu Met Gly Ala Arg Ala Ala Lys Ala Val Glu 520 525 530 tcg ggg gcc ctg gag ctc agt ccc tcc ttc cac cag aag aac tgg cag 2168 Ser Gly Ala Leu Glu Leu Ser Pro Ser Phe His Gln Lys Asn Trp Gln 535 540 545 cac tgg ttt tcc cat att ggg gac tgg tgt gtc tcc cgg cag ctg tgg 2216 His Trp Phe Ser His Ile Gly Asp Trp Cys Val Ser Arg Gln Leu Trp 550 555 560 tgg ggc cat cag att cca gcc tac ctg gtt gta gag gac cat gcg cag 2264 Trp Gly His Gln Ile Pro Ala Tyr Leu Val Val Glu Asp His Ala Gln 565 570 575 gga gaa gag gac tgt tgg gtg gtt ggg cgg tca gag gct gag gcc aga 2312 Gly Glu Glu Asp Cys Trp Val Val Gly Arg Ser Glu Ala Glu Ala Arg 580 585 590 595 gag gta gca gcg gaa ctg aca ggg agg cca ggg gca gag ctg acc ctg 2360 Glu Val Ala Ala Glu Leu Thr Gly Arg Pro Gly Ala Glu Leu Thr Leu 600 605 610 gag agg gat cct gat gtc cta gac aca tgg ttt tct tct gcc ctg ttc 2408 Glu Arg Asp Pro Asp Val Leu Asp Thr Trp Phe Ser Ser Ala Leu Phe 615 620 625 ccc ttt tct gcc ctg ggc tgg ccc caa gag acc cca gac ctt gct cgt 2456 Pro Phe Ser Ala Leu Gly Trp Pro Gln Glu Thr Pro Asp Leu Ala Arg 630 635 640 ttc tac ccc ctg tca ctt ttg gaa acg ggc agc gac ctt ctg ctg ttc 2504 Phe Tyr Pro Leu Ser Leu Leu Glu Thr Gly Ser Asp Leu Leu Leu Phe 645 650 655 tgg gtg ggc cgc atg gtc atg ttg ggg acc cag ctc aca ggg cag ctg 2552 Trp Val Gly Arg Met Val Met Leu Gly Thr Gln Leu Thr Gly Gln Leu 660 665 670 675 ccc ttc agc aag gtg ctt ctt cat ccc atg gtt cgg gac agg cag ggc 2600 Pro Phe Ser Lys Val Leu Leu His Pro Met Val Arg Asp Arg Gln Gly 680 685 690 cgg aag atg agc aag tcc ctg ggg aat gtg ctg gac cca aga gac atc 2648 Arg Lys Met Ser Lys Ser Leu Gly Asn Val Leu Asp Pro Arg Asp Ile 695 700 705 atc agt ggg gtg gag atg cag gtg ctg cag gaa aag ctg aga agc gga 2696 Ile Ser Gly Val Glu Met Gln Val Leu Gln Glu Lys Leu Arg Ser Gly 710 715 720 aat ttg gac cct gca gag ctg gcc att gtg gct gca gca cag aaa aag 2744 Asn Leu Asp Pro Ala Glu Leu Ala Ile Val Ala Ala Ala Gln Lys Lys 725 730 735 gac ttt cct cac ggg atc cct gag tgt ggg aca gat gcc ctg aga ttc 2792 Asp Phe Pro His Gly Ile Pro Glu Cys Gly Thr Asp Ala Leu Arg Phe 740 745 750 755 aca ctc tgc tcc cat gga gtt cag gcg ggc gac ttg cac ctg tca gtc 2840 Thr Leu Cys Ser His Gly Val Gln Ala Gly Asp Leu His Leu Ser Val 760 765 770 tct gag gtc cag agc tgc cga cat ttc tgc aac aag atc tgg aat gct 2888 Ser Glu Val Gln Ser Cys Arg His Phe Cys Asn Lys Ile Trp Asn Ala 775 780 785 ctt cgc ttt atc ctc aat gct tta ggg gag aaa ttt gtg cca cag cct 2936 Leu Arg Phe Ile Leu Asn Ala Leu Gly Glu Lys Phe Val Pro Gln Pro 790 795 800 gct gag gag ctg tct ccc tcc tcc ccg atg gat gcc tgg atc ctg agc 2984 Ala Glu Glu Leu Ser Pro Ser Ser Pro Met Asp Ala Trp Ile Leu Ser 805 810 815 cgc ctt gcc ctg gct gcc cag gag tgt gag cgg ggc ttc ctc acc cga 3032 Arg Leu Ala Leu Ala Ala Gln Glu Cys Glu Arg Gly Phe Leu Thr Arg 820 825 830 835 gag ctc tcg ctc gtc act cat gcc ctg cac cac ttc tgg ctt cac aac 3080 Glu Leu Ser Leu Val Thr His Ala Leu His His Phe Trp Leu His Asn 840 845 850 ctc tgt gac gtc tac ctg gag gct gtg aag ccc gtg ctg tgg cac tcg 3128 Leu Cys Asp Val Tyr Leu Glu Ala Val Lys Pro Val Leu Trp His Ser 855 860 865 ccc cgc ccc ctg ggg ccc cct cag gtc ctg ttc tcc tgc gct gac ctc 3176 Pro Arg Pro Leu Gly Pro Pro Gln Val Leu Phe Ser Cys Ala Asp Leu 870 875 880 ggc ctc cgc ctc ctg gcc cca ctg atg ccc ttc ctg gct gaa gag ctc 3224 Gly Leu Arg Leu Leu Ala Pro Leu Met Pro Phe Leu Ala Glu Glu Leu 885 890 895 tgg cag agg ctg ccc ccc agg cct ggt tgc ccc cct gcc ccc agc atc 3272 Trp Gln Arg Leu Pro Pro Arg Pro Gly Cys Pro Pro Ala Pro Ser Ile 900 905 910 915 tcg gtt gcc ccc tac ccc agc gcc tgc agc ttg gag cac tgg cgc cag 3320 Ser Val Ala Pro Tyr Pro Ser Ala Cys Ser Leu Glu His Trp Arg Gln 920 925 930 cca gag ctg gag cgg cgc ttc tcc cgg gtc caa gag gtc gtg cag gtg 3368 Pro Glu Leu Glu Arg Arg Phe Ser Arg Val Gln Glu Val Val Gln Val 935 940 945 cta agg gct ctc cga gcc acg tac cag ctc acc aaa gcc cgg ccc cga 3416 Leu Arg Ala Leu Arg Ala Thr Tyr Gln Leu Thr Lys Ala Arg Pro Arg 950 955 960 gtg ctg ctg cag agc tca gag cct ggg gac cag ggc ctc ttc gag gcc 3464 Val Leu Leu Gln Ser Ser Glu Pro Gly Asp Gln Gly Leu Phe Glu Ala 965 970 975 ttc ttg gag ccc ctg ggc acc ctg ggc tac tgt ggg gct gtg ggc ctg 3512 Phe Leu Glu Pro Leu Gly Thr Leu Gly Tyr Cys Gly Ala Val Gly Leu 980 985 990 995 tta ccc cca ggc gca gca gct ccc tcc ggc tgg gcc cag gct cca ctc 3560 Leu Pro Pro Gly Ala Ala Ala Pro Ser Gly Trp Ala Gln Ala Pro Leu 1000 1005 1010 agt gac acg gct caa gtc tac atg gag ctg cag ggc ctg gtg gac ccg 3608 Ser Asp Thr Ala Gln Val Tyr Met Glu Leu Gln Gly Leu Val Asp Pro 1015 1020 1025 cag atc cag cta cct ctg tta gcc gcc cga agg tac aag ttg cag aag 3656 Gln Ile Gln Leu Pro Leu Leu Ala Ala Arg Arg Tyr Lys Leu Gln Lys 1030 1035 1040 cag ctt gat agc ctc aca gcc agg acc cca tca gaa ggg gag gca ggg 3704 Gln Leu Asp Ser Leu Thr Ala Arg Thr Pro Ser Glu Gly Glu Ala Gly 1045 1050 1055 act cag agg caa caa aag ctt tct tcc ctc cag ctg gaa ttg tca aaa 3752 Thr Gln Arg Gln Gln Lys Leu Ser Ser Leu Gln Leu Glu Leu Ser Lys 1060 1065 1070 1075 ctg gac aag gca gcc tct cac ctc cag cag ctg atg gat gag cct cca 3800 Leu Asp Lys Ala Ala Ser His Leu Gln Gln Leu Met Asp Glu Pro Pro 1080 1085 1090 gcc cca ggg agc ccg gag ctc taactcatca tccccatcag ttttcctccc 3851 Ala Pro Gly Ser Pro Glu Leu 1095 tctcagacct gtctttgagg acaaacagat ttgtcagctg tcagggtgca gtgggacgtc 3911 agagactatg tggtccatcg ccttcattgt gtaaatgagg acacagactg gcttggtcgc 3971 agtgactgtg gtgtccttga gatgctcaca ttactgcccg gcctgcctcc cacctggaag 4031 tctgggaatg aggagattga gataaacttt tgaaatccc 4070 <210> 17 <211> 3960 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1645)..(3636) <400> 17 gcggccgcag cgccgtctgc tcagcgcccg ggtcaatagg agccagtcct tcgcaggcgt 60 cctcggcagc cacgagcggg ggcccaggag tttcccggtc ttcagcccgc cggggccccc 120 acggaagccc cccgcgctct cccgagtgtc caggatgttt tccgtggctc acccagccgc 180 caaggtgccg cagcccgagc ggctggacct ggtgtacacg gcgctgaagc ggggcctgac 240 ggcctacttg gaagtgcacc agcaggagca agagaaactc caggggcaga taagggagtc 300 caagaggaat tcccgcttgg gcttcctgta tgatctggac aagcaagtca agtccattga 360 acgcttcctg cgacgactgg agttccatgc cagcaagatc gatgagctgt atgaggcata 420 ctgtgtccag cggcgtctcc gggatggtgc ctacaacatg gtccgtgcct acaccactgg 480 gtccccggga agccgagagg cccgggacag cctggcagag gccactcggg ggcatcgcga 540 gtacacggag agcatgtgtc tgctggagag cgagctggag gcacagctgg gcgagtttca 600 tctccgaatg aaagggctgg ctggcttcgc caggctgtgt gtaggcgatc agtatgagat 660 ctgcatgaaa tatgggcgtc agcgctggaa actacggggc cgaattgagg gtagtggaaa 720 gcaggtgtgg gacagtgaag aaaccatctt tctccctcta ctcacggaat ttctgtctat 780 taaggtgaca gaactgaagg gcctggccaa ccatgtggtt gtgggcagtg tctcctgtga 840 gaccaaggac ctgtttgccg ccctgcccca ggttgtggct gtggatatca atgaccttgg 900 taccatcaag ctcagcctgg aagtcacatg gagccccttc gacaaggatg accagccctc 960 agctgcttct tctgtcaaca aggcctccac agtcaccaag cgcttctcca cctatagcca 1020 gagcccaccg gacacaccct cacttcggga acaggctttc tataacatgc tgcgacggca 1080 ggaggagctg gagaatggga cagcatggtc cctgtcatct gaatcttcag acgactcatc 1140 cagcccacag ctctcaggca ctgcccgcca ctcaccagcc cctaggcccc tggtgcagca 1200 gcccgagccc cttcccatcc aagttgcctt ccgcaggcct gagaccccca gctctgggcc 1260 cttggatgag gagggggccg tggccccagt cctggcaaat gggcatgcac cctacagtcg 1320 gactctgagc cacatcagtg aggctagtgt agatgctgcc ttggctgagg cttcagtgga 1380 ggccgttggc ccagaaagcc tagcctgggg acctagccca cctacacacc cagctcccac 1440 ccatggagag caccccagtc ctgttcctcc tgccctggac cctggccact ctgccacaag 1500 ctctaccctc ggtacaacag gctctgtccc cacatctaca gaccctgccc catctgcaca 1560 cctagactca gttcataagt ccacagactc tggcccttca gaactgccag gccccactca 1620 caccactaca ggctctacct atag tgc cat tac cac tac cca cag tgc tcc 1671 Cys His Tyr His Tyr Pro Gln Cys Ser 1 5 aag ccc cct cac tca cac tac tac agg ctc cac ccc aag ccc ata atc 1719 Lys Pro Pro His Ser His Tyr Tyr Arg Leu His Pro Lys Pro Ile Ile 10 15 20 25 tct acc ctt act act aca ggc cct acc ctc aat atc ata ggc cca gtc 1767 Ser Thr Leu Thr Thr Thr Gly Pro Thr Leu Asn Ile Ile Gly Pro Val 30 35 40 cag act acc aca agc ccc acc cac act atg cca agc cct acc cat acc 1815 Gln Thr Thr Thr Ser Pro Thr His Thr Met Pro Ser Pro Thr His Thr 45 50 55 aca gca agc ccc act cat act tcc aca agc ccc acc cat acc ccc aca 1863 Thr Ala Ser Pro Thr His Thr Ser Thr Ser Pro Thr His Thr Pro Thr 60 65 70 agt ccc acc cac aaa acc agt atg tca cct ccc acc act aca agt cct 1911 Ser Pro Thr His Lys Thr Ser Met Ser Pro Pro Thr Thr Thr Ser Pro 75 80 85 acc ccc agt ggt atg ggc cta gtc cag act gcc aca agt ccc acc cat 1959 Thr Pro Ser Gly Met Gly Leu Val Gln Thr Ala Thr Ser Pro Thr His 90 95 100 105 cct acc aca agc ccc acc cat ccc acc aca agc ccc atc ctt ata aat 2007 Pro Thr Thr Ser Pro Thr His Pro Thr Thr Ser Pro Ile Leu Ile Asn 110 115 120 gta agc cct tcc act tct cta gaa ctt gct acc ctc tcc agc ccc tcc 2055 Val Ser Pro Ser Thr Ser Leu Glu Leu Ala Thr Leu Ser Ser Pro Ser 125 130 135 aaa cac tca gac ccc acc ctc cca ggc act gac tcc ctt ccc tgt agt 2103 Lys His Ser Asp Pro Thr Leu Pro Gly Thr Asp Ser Leu Pro Cys Ser 140 145 150 ccc cca gtc tcc aat tcc tac act cag gca gac cct atg gcc ccc aga 2151 Pro Pro Val Ser Asn Ser Tyr Thr Gln Ala Asp Pro Met Ala Pro Arg 155 160 165 act ccc cac cca agt cct gcc cat tcc agt agg aaa ccc ctc aca agc 2199 Thr Pro His Pro Ser Pro Ala His Ser Ser Arg Lys Pro Leu Thr Ser 170 175 180 185 cct gcc cca gat ccc tca gag tct acg gtt cag agt cta agc ccc act 2247 Pro Ala Pro Asp Pro Ser Glu Ser Thr Val Gln Ser Leu Ser Pro Thr 190 195 200 ccc tca ccc cca acc cct gca ccc cag cat tca gac ctt tgc ctg gcc 2295 Pro Ser Pro Pro Thr Pro Ala Pro Gln His Ser Asp Leu Cys Leu Ala 205 210 215 atg gct gtc cag acc cca gtc cca acg gca gcc gga ggg tct ggg gac 2343 Met Ala Val Gln Thr Pro Val Pro Thr Ala Ala Gly Gly Ser Gly Asp 220 225 230 agg agc ctg gag gag gca ctg ggg gcc cta atg gct gcc ctg gat gac 2391 Arg Ser Leu Glu Glu Ala Leu Gly Ala Leu Met Ala Ala Leu Asp Asp 235 240 245 tac cgt ggc cag ttt cct gag ctg cag ggc ctg gag cag gag gtg acc 2439 Tyr Arg Gly Gln Phe Pro Glu Leu Gln Gly Leu Glu Gln Glu Val Thr 250 255 260 265 cgc cta gaa agt ctg ctc atg aga caa ggt ctg act cgc agc cgg gcc 2487 Arg Leu Glu Ser Leu Leu Met Arg Gln Gly Leu Thr Arg Ser Arg Ala 270 275 280 tcc agt ctc agc atc act gtg gag cat gcc ttg gag agc ttc agc ttc 2535 Ser Ser Leu Ser Ile Thr Val Glu His Ala Leu Glu Ser Phe Ser Phe 285 290 295 ctc aat gaa gac gaa gat gaa gac aat gat gtt cct ggg gac agg cct 2583 Leu Asn Glu Asp Glu Asp Glu Asp Asn Asp Val Pro Gly Asp Arg Pro 300 305 310 cca agc agc ccg gag gct ggg gct gag gac agc ata gac tca ccc agt 2631 Pro Ser Ser Pro Glu Ala Gly Ala Glu Asp Ser Ile Asp Ser Pro Ser 315 320 325 gcc cgc ccc ctc agc acg ggg tgt cca gct ctg gat gct gcc ttg gtc 2679 Ala Arg Pro Leu Ser Thr Gly Cys Pro Ala Leu Asp Ala Ala Leu Val 330 335 340 345 cgg cac ctg tac cac tgc agt cgc ctc ctg ctg aaa ctg ggc aca ttt 2727 Arg His Leu Tyr His Cys Ser Arg Leu Leu Leu Lys Leu Gly Thr Phe 350 355 360 ggg ccc ctg cgc tgc cag gag gca tgg gcc ctg gag cgg ctg ctg cgg 2775 Gly Pro Leu Arg Cys Gln Glu Ala Trp Ala Leu Glu Arg Leu Leu Arg 365 370 375 gaa gcc cga gta ctg gag gca gta tgc gag ttc agc agg cgg tgg gag 2823 Glu Ala Arg Val Leu Glu Ala Val Cys Glu Phe Ser Arg Arg Trp Glu 380 385 390 atc ccg gcc agc tct gcc cag gaa gtg gtg cag ttc tcg gcc tct cgg 2871 Ile Pro Ala Ser Ser Ala Gln Glu Val Val Gln Phe Ser Ala Ser Arg 395 400 405 cct ggc ttc ctg acc ttc tgg gac cag tgc aca gag aga ctc agc tgc 2919 Pro Gly Phe Leu Thr Phe Trp Asp Gln Cys Thr Glu Arg Leu Ser Cys 410 415 420 425 ttc ctc tgc ccg gtg gag cgg gtg ctt ctc acc ttc tgc aac cag tat 2967 Phe Leu Cys Pro Val Glu Arg Val Leu Leu Thr Phe Cys Asn Gln Tyr 430 435 440 ggt gcc cgc ctc tcc ctg cgc cag cca ggc ttg gct gag gct gtg tgt 3015 Gly Ala Arg Leu Ser Leu Arg Gln Pro Gly Leu Ala Glu Ala Val Cys 445 450 455 gtg aag ttc ctg gag gat gcc ctg ggg cag aag ctg ccc aga agg ccc 3063 Val Lys Phe Leu Glu Asp Ala Leu Gly Gln Lys Leu Pro Arg Arg Pro 460 465 470 cag cca ggg cct gga gag cag ctc aca gtc ttc cag ttc tgg agt ttt 3111 Gln Pro Gly Pro Gly Glu Gln Leu Thr Val Phe Gln Phe Trp Ser Phe 475 480 485 gtg gaa acc ttg gac agc ccc acc atg gag gcc tac gtg act gag acc 3159 Val Glu Thr Leu Asp Ser Pro Thr Met Glu Ala Tyr Val Thr Glu Thr 490 495 500 505 gct gag gag gtg cta ctg gtg cgg aat ctg aac tcg gat gat cag gct 3207 Ala Glu Glu Val Leu Leu Val Arg Asn Leu Asn Ser Asp Asp Gln Ala 510 515 520 gtt gtg ctg aag gcc ctg aga ttg gcg ccc gag ggg cgt ctg cga agg 3255 Val Val Leu Lys Ala Leu Arg Leu Ala Pro Glu Gly Arg Leu Arg Arg 525 530 535 gac ggg ctg cgg gcc ctc agc tcc ctg ctc gtc cat ggc aac aac aag 3303 Asp Gly Leu Arg Ala Leu Ser Ser Leu Leu Val His Gly Asn Asn Lys 540 545 550 gtc atg gct gct gtc agc acc cag ctc cgg agc ctg tca ctg ggc cct 3351 Val Met Ala Ala Val Ser Thr Gln Leu Arg Ser Leu Ser Leu Gly Pro 555 560 565 acc ttc cgg gag agg gcc ctc ctg tgc ttc ctg gac cag ctg gag gat 3399 Thr Phe Arg Glu Arg Ala Leu Leu Cys Phe Leu Asp Gln Leu Glu Asp 570 575 580 585 gag gac gtg cag act cga gtg gct ggc tgc ctg gcc cta ggc tgc atc 3447 Glu Asp Val Gln Thr Arg Val Ala Gly Cys Leu Ala Leu Gly Cys Ile 590 595 600 aag gct ccc gag ggc att gag ccc ctg gtg tac ctc tgc caa act gac 3495 Lys Ala Pro Glu Gly Ile Glu Pro Leu Val Tyr Leu Cys Gln Thr Asp 605 610 615 aca gaa gct gtg agg gaa gct gcc cgg caa agc cta cag cag tgt gga 3543 Thr Glu Ala Val Arg Glu Ala Ala Arg Gln Ser Leu Gln Gln Cys Gly 620 625 630 gaa gag gga cag tct gcc cat cga cgg ctg gag gag tcc ctg gac gcc 3591 Glu Glu Gly Gln Ser Ala His Arg Arg Leu Glu Glu Ser Leu Asp Ala 635 640 645 ctg ccc cgc atc ttt ggg cct ggc agc atg gcc agc aca gca ttc 3636 Leu Pro Arg Ile Phe Gly Pro Gly Ser Met Ala Ser Thr Ala Phe 650 655 660 taaactattc acccatgggt tcctggtgcc cctttccccc cactttcagg gctcaccagg 3696 cactggcagg gagggtaagg gctggctcca gatacccctc ccccacagat tcctagcaat 3756 gaaaatctaa tatattcttc tgttgcccct ggggttggag agtcagtgcc tgcagtcaag 3816 tgcctcccag cctcggctca gcacatccct tgccacaaat cagtgtctgg ggcttggcca 3876 ccctgccgct gcccagccac atcccttggt tttgtatttt atttacagag ttttacagaa 3936 aataaaaaag caaaatgtct ttcc 3960 <210> 18 <211> 3957 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(2401) <400> 18 c gcg ggg ttg ctg cgg gag tcc ggg gat gtg gtc ctg tct ggc tgt agc 49 Ala Gly Leu Leu Arg Glu Ser Gly Asp Val Val Leu Ser Gly Cys Ser 1 5 10 15 acc ctg agc ctg ctg act ccc aca ctg caa cag ctg aac cac gta ttt 97 Thr Leu Ser Leu Leu Thr Pro Thr Leu Gln Gln Leu Asn His Val Phe 20 25 30 gag ctg cac ctg ggg cca tgg ggc cct ggc cag aca ggc ttt gtg gct 145 Glu Leu His Leu Gly Pro Trp Gly Pro Gly Gln Thr Gly Phe Val Ala 35 40 45 ctg ccc tcc cat cct gcc gac tcc cct gtt att ctt cag ctt cag ttt 193 Leu Pro Ser His Pro Ala Asp Ser Pro Val Ile Leu Gln Leu Gln Phe 50 55 60 ctc ttc gat gtg ctg cag aaa aca ctt tca ctc aag ctg gtc cat gtt 241 Leu Phe Asp Val Leu Gln Lys Thr Leu Ser Leu Lys Leu Val His Val 65 70 75 80 gct ggt cct ggc ccc aca ggg ccc atc aag att ttc ccc ttc aaa tcc 289 Ala Gly Pro Gly Pro Thr Gly Pro Ile Lys Ile Phe Pro Phe Lys Ser 85 90 95 ctt cgg cac ctg gag ctc cga ggt gtt ccc ctc cac tgt ctg cat ggc 337 Leu Arg His Leu Glu Leu Arg Gly Val Pro Leu His Cys Leu His Gly 100 105 110 ctc cga ggc atc tac tcc cag ctg gag acc ctg att tgc agc agg agc 385 Leu Arg Gly Ile Tyr Ser Gln Leu Glu Thr Leu Ile Cys Ser Arg Ser 115 120 125 ctc cag gca tta gag gag ctc ctc tca gcc tgc ggc ggc gac ttc tgc 433 Leu Gln Ala Leu Glu Glu Leu Leu Ser Ala Cys Gly Gly Asp Phe Cys 130 135 140 tct gcc ctc cct tgg ctg gct ctg ctt tct gcc aac ttc agc tac aat 481 Ser Ala Leu Pro Trp Leu Ala Leu Leu Ser Ala Asn Phe Ser Tyr Asn 145 150 155 160 gca ctg acc gcc tta gac agc tcc ctg cgc ctc ttg tca gct ctg cgt 529 Ala Leu Thr Ala Leu Asp Ser Ser Leu Arg Leu Leu Ser Ala Leu Arg 165 170 175 ttc ttg aac cta agc cac aat caa gtc cag gac tgt cag gga ttc ctg 577 Phe Leu Asn Leu Ser His Asn Gln Val Gln Asp Cys Gln Gly Phe Leu 180 185 190 atg gat ttg tgt gag ctc cac cat ctg gac atc tcc tat aat cgc ctg 625 Met Asp Leu Cys Glu Leu His His Leu Asp Ile Ser Tyr Asn Arg Leu 195 200 205 cat ttg gtg cca aga atg gga ccc tca ggg gct gct ctg ggg gtc ctg 673 His Leu Val Pro Arg Met Gly Pro Ser Gly Ala Ala Leu Gly Val Leu 210 215 220 ata ctg cga ggc aat gag ctt cgg agc ctg cat ggc cta gag cag ctg 721 Ile Leu Arg Gly Asn Glu Leu Arg Ser Leu His Gly Leu Glu Gln Leu 225 230 235 240 agg aat ctg cgg cac ctg gat ttg gca tac aac ctg ctg gaa gga cac 769 Arg Asn Leu Arg His Leu Asp Leu Ala Tyr Asn Leu Leu Glu Gly His 245 250 255 cgg gag ctg tca cca ctg tgg ctg ctg gct gag ctc cgc aag ctc tac 817 Arg Glu Leu Ser Pro Leu Trp Leu Leu Ala Glu Leu Arg Lys Leu Tyr 260 265 270 ctg gag ggg aac cct ctt tgg ttc cac cct gag cac cga gca gcc act 865 Leu Glu Gly Asn Pro Leu Trp Phe His Pro Glu His Arg Ala Ala Thr 275 280 285 gcc cag tac ttg tca ccc cgg gcc agg gat gct gct act ggc ttc ctt 913 Ala Gln Tyr Leu Ser Pro Arg Ala Arg Asp Ala Ala Thr Gly Phe Leu 290 295 300 ctc gat ggc aag gtc ttg tca ctg aca gat ttt cag act cac aca tcc 961 Leu Asp Gly Lys Val Leu Ser Leu Thr Asp Phe Gln Thr His Thr Ser 305 310 315 320 ttg ggg ctc agc ccc atg ggc cca cct ttg ccc tgg cca gtg ggg agt 1009 Leu Gly Leu Ser Pro Met Gly Pro Pro Leu Pro Trp Pro Val Gly Ser 325 330 335 act cct gaa acc tca ggt ggc cct gac ctg agt gac agc ctc tcc tca 1057 Thr Pro Glu Thr Ser Gly Gly Pro Asp Leu Ser Asp Ser Leu Ser Ser 340 345 350 ggg ggt gtt gtg acc cag ccc ctg ctt cat aag gtt aag agc cga gtc 1105 Gly Gly Val Val Thr Gln Pro Leu Leu His Lys Val Lys Ser Arg Val 355 360 365 cgt gtg agg cgg gca agc atc tct gaa ccc agt gat acg gac ccg gag 1153 Arg Val Arg Arg Ala Ser Ile Ser Glu Pro Ser Asp Thr Asp Pro Glu 370 375 380 ccc cga act ctg aac ccc tct ccg gct gga tgg ttc gtg cag cag cac 1201 Pro Arg Thr Leu Asn Pro Ser Pro Ala Gly Trp Phe Val Gln Gln His 385 390 395 400 ccg gag ctg gag ctc atg agc agc ttc cgg gaa cgg ttc ggc cgc aac 1249 Pro Glu Leu Glu Leu Met Ser Ser Phe Arg Glu Arg Phe Gly Arg Asn 405 410 415 tgg ctg cag tac agg agt cac ctg gag ccc tcc gga aac cct ctg ccg 1297 Trp Leu Gln Tyr Arg Ser His Leu Glu Pro Ser Gly Asn Pro Leu Pro 420 425 430 gcc acc ccc act act tct gca ccc agt gca cct cca gcc agc tcc cag 1345 Ala Thr Pro Thr Thr Ser Ala Pro Ser Ala Pro Pro Ala Ser Ser Gln 435 440 445 ggc ccc gac act gca ccc aga cct tca ccc ccg cag gag gaa gcc aga 1393 Gly Pro Asp Thr Ala Pro Arg Pro Ser Pro Pro Gln Glu Glu Ala Arg 450 455 460 ggc ccc cag gag tca cca cag aaa atg tca gag gag gtc agg gcg gag 1441 Gly Pro Gln Glu Ser Pro Gln Lys Met Ser Glu Glu Val Arg Ala Glu 465 470 475 480 cca cag gag gag gaa gag gag aag gag ggg aag gag gag aag gag gag 1489 Pro Gln Glu Glu Glu Glu Glu Lys Glu Gly Lys Glu Glu Lys Glu Glu 485 490 495 ggg gag atg gtg gaa cag gga gaa gag gag gca gga gag gag gaa gaa 1537 Gly Glu Met Val Glu Gln Gly Glu Glu Glu Ala Gly Glu Glu Glu Glu 500 505 510 gag gag cag gac cag aag gaa gtg gaa gcg gaa ctc tgt cgc ccc ttg 1585 Glu Glu Gln Asp Gln Lys Glu Val Glu Ala Glu Leu Cys Arg Pro Leu 515 520 525 ttg gtg tgt ccc ctg gag ggg cct gag ggc gta cgg ggc agg gaa tgc 1633 Leu Val Cys Pro Leu Glu Gly Pro Glu Gly Val Arg Gly Arg Glu Cys 530 535 540 ttt ctc agg gtc act tct gcc cac ctg ttt gag gtg gaa ctc caa gca 1681 Phe Leu Arg Val Thr Ser Ala His Leu Phe Glu Val Glu Leu Gln Ala 545 550 555 560 gct cgc acc ttg gag cga ctg gag ctc cag agt ctg gag gca gct gag 1729 Ala Arg Thr Leu Glu Arg Leu Glu Leu Gln Ser Leu Glu Ala Ala Glu 565 570 575 ata gag ccg gag gcc cag gcc cag agg tcg ccc agg ccc acg ggc tca 1777 Ile Glu Pro Glu Ala Gln Ala Gln Arg Ser Pro Arg Pro Thr Gly Ser 580 585 590 gat ctg ctc cct gga gcc ccc atc ctc agt ctg cgc ttc tcc tac atc 1825 Asp Leu Leu Pro Gly Ala Pro Ile Leu Ser Leu Arg Phe Ser Tyr Ile 595 600 605 tgc cct gac cgg cag ttg cgt cgc tat ttg gtg ctg gag cct gat gcc 1873 Cys Pro Asp Arg Gln Leu Arg Arg Tyr Leu Val Leu Glu Pro Asp Ala 610 615 620 cac gca gct gtc cag gag ctg ctt gcc gtg ttg acc cca gtc acc aat 1921 His Ala Ala Val Gln Glu Leu Leu Ala Val Leu Thr Pro Val Thr Asn 625 630 635 640 gtg gct cgg gaa cag ctt ggg gag gcc agg gac ctc ctg ctg ggt aga 1969 Val Ala Arg Glu Gln Leu Gly Glu Ala Arg Asp Leu Leu Leu Gly Arg 645 650 655 ttc cag tgt cta cgc tgt ggc cat gag ttc aag cca gag gag ccc agg 2017 Phe Gln Cys Leu Arg Cys Gly His Glu Phe Lys Pro Glu Glu Pro Arg 660 665 670 atg gga tta gac agt gag gaa ggc tgg agg cct ctg ttc caa aag aca 2065 Met Gly Leu Asp Ser Glu Glu Gly Trp Arg Pro Leu Phe Gln Lys Thr 675 680 685 ggg agc gga aac agg gag agc agt ctc tgg ctc ctt ctc cgt ttg cca 2113 Gly Ser Gly Asn Arg Glu Ser Ser Leu Trp Leu Leu Leu Arg Leu Pro 690 695 700 gcc ctg tct gcc acc ctc ctg gcc atg gtg acc acc ttg aca ggg cca 2161 Ala Leu Ser Ala Thr Leu Leu Ala Met Val Thr Thr Leu Thr Gly Pro 705 710 715 720 aga aca gcc cac ctc agg cac cga gca ccc gtg acc atg gta gtt gga 2209 Arg Thr Ala His Leu Arg His Arg Ala Pro Val Thr Met Val Val Gly 725 730 735 gcc tca gtc ccc ccc ctg agc gct gtg gcc tcc gct ctg tgg acc acc 2257 Ala Ser Val Pro Pro Leu Ser Ala Val Ala Ser Ala Leu Trp Thr Thr 740 745 750 gac tcc ggc tct tcc tgg atg ttg agg tgt tca gcg atg ccc agg agg 2305 Asp Ser Gly Ser Ser Trp Met Leu Arg Cys Ser Ala Met Pro Arg Arg 755 760 765 agt tcc agt gct gcc tca agg tgc cag tgg cat tgg cag gcc aca ctg 2353 Ser Ser Ser Ala Ala Ser Arg Cys Gln Trp His Trp Gln Ala Thr Leu 770 775 780 ggg agt tca tgt gcc ttg tgg ttg tgt ctg acc gca ggc tgt acc tgt 2401 Gly Ser Ser Cys Ala Leu Trp Leu Cys Leu Thr Ala Gly Cys Thr Cys 785 790 795 800 tgaaggtgac tggggagatg cgtgagcctc cagctagctg gctgcagctg accctggctg 2461 ttcccctgca ggatctgagt ggcatagagc tgggcctggc aggccagagc ctgcggctag 2521 agtgggcagc tggggcgggc cgctgtgtgc tgctgccccg agatgccagg cattgccggg 2581 ccttcctaga ggagctcctt gatgtcttgc agtctctgcc ccctgcctgg aggaactgtg 2641 tcagtgccac agaggaggag gtcacccccc agcaccggct ctggccattg ctggaaaaag 2701 actcatcctt ggaggctcgc cagttcttct accttcgggc gttcctggtt gaaggtgaag 2761 cctctgtgca gctgatgctt ccctggtctc tgtaccccac cttgtcacag gcactggccc 2821 acgcgcagca cctgtacagt gcccttgcag caactgtcag ttcctggaac ctggagaacc 2881 tctcacttga gggcatagct gagtaacagc ctcagtgtgc cctgaccctc tgggtggggt 2941 taggaggcac ccaggatcct cagttaccca gagcctttgc tctcgggccc aggctttcta 3001 tgaagtggag cagcgtggct gagtcggccc tgcctcatca gtcacagaag gagagggtgg 3061 agccttgttt ctgagtaggg tgggtgtggg gcagtggggg gcggtaggcc tcagaggtat 3121 tccagagtag agattcatgg agcttgggaa agggagggtc ttggccccag gggcacaggc 3181 tgctttgtga cccacctcag agtgtggttc acacctcttc tccccagcag cactgggacg 3241 ctggccccag ggatctgggc ccctccatga ccttccacac tggatgcctc tttccctgca 3301 ggcccttcca cctgcctcgt atccctgttg ctgactccgt ccaccctgtt cctgttagat 3361 gaggatgctg cagggtcccc ggcagagccc tctcctccag cagcatctgg cgaagcctct 3421 gagaaggtgc ctccctcggg gccgggccct gctgtgcgtg tcagggagca gcagccactc 3481 agcagcctga gctccgtgct gctctaccgc tcagcccctg aggacttgcg gctgctcttc 3541 tacgatgagg tgtcccggct ggagagcttt tgggcactcc gtgtggtgtg tcaggagcag 3601 ctgacagccc tgcttgcctg gatccgggaa ccatgggagg agctgttttc catcggactc 3661 cggacagtga tccaagaggc gctggccctt gaccgatgag ggtcccacgc tgaccttggc 3721 cctgacctca ggagccacgc tgtagacatt ccctctcctg gtctctgggt ctggcttcca 3781 ggctctggct gtggatgtct tcagcctctg ggtgctggcc agtgaggtcc caaatgaccc 3841 agggcttaag ggagaggcga gagaatgatc tggcctcagg ggacaggcca cctggtcagg 3901 aggaatattt ttcctgcact ttttctcagg tatcaataaa gttgtttcca actcat 3957 <210> 19 <211> 3037 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(787) <400> 19 g ttt gat ggt cca ccc cag cca gag aat ctg cgt acg agg ctc aca ggc 49 Phe Asp Gly Pro Pro Gln Pro Glu Asn Leu Arg Thr Arg Leu Thr Gly 1 5 10 15 ttt cag ctg cca gcc acc att gtt agt gca gcc acc acc ctc tct ctg 97 Phe Gln Leu Pro Ala Thr Ile Val Ser Ala Ala Thr Thr Leu Ser Leu 20 25 30 cgc ctc atc agc gac tat gca gtc agt gcc caa ggc ttc cac gcc acc 145 Arg Leu Ile Ser Asp Tyr Ala Val Ser Ala Gln Gly Phe His Ala Thr 35 40 45 tat gaa gtt ctc ccc agc cac aca tgt ggg aac cca ggg agg ctg ccc 193 Tyr Glu Val Leu Pro Ser His Thr Cys Gly Asn Pro Gly Arg Leu Pro 50 55 60 aat ggc atc cag cag ggt tca acc ttc aac ctc ggt gac aag gtc cgc 241 Asn Gly Ile Gln Gln Gly Ser Thr Phe Asn Leu Gly Asp Lys Val Arg 65 70 75 80 tac agc tgc aac ctt ggc ttc ttc ctg gag ggc cac gcc gtg ctc acc 289 Tyr Ser Cys Asn Leu Gly Phe Phe Leu Glu Gly His Ala Val Leu Thr 85 90 95 tgc cac gct ggc tct gag aac agc gcc acg tgg gac ttc ccc ctg cct 337 Cys His Ala Gly Ser Glu Asn Ser Ala Thr Trp Asp Phe Pro Leu Pro 100 105 110 tcc tgc aga gct gat gat gcc tgt ggt ggg acc ctg cgg ggc cag agt 385 Ser Cys Arg Ala Asp Asp Ala Cys Gly Gly Thr Leu Arg Gly Gln Ser 115 120 125 ggc atc atc tcc agc ccc cac ttc ccc tcg gag tac cat aac aat gcc 433 Gly Ile Ile Ser Ser Pro His Phe Pro Ser Glu Tyr His Asn Asn Ala 130 135 140 gac tgc aca tgg acc atc ctg gct gag ctg ggg gac acc atc gcc ctg 481 Asp Cys Thr Trp Thr Ile Leu Ala Glu Leu Gly Asp Thr Ile Ala Leu 145 150 155 160 gtg ttt att gac ttc cag ctg gag gat ggt tac gac ttt ctg gaa gtc 529 Val Phe Ile Asp Phe Gln Leu Glu Asp Gly Tyr Asp Phe Leu Glu Val 165 170 175 act ggg aca gaa ggc tcc tcc ctc tgg ttc acc gga gcc agc ctc cca 577 Thr Gly Thr Glu Gly Ser Ser Leu Trp Phe Thr Gly Ala Ser Leu Pro 180 185 190 gcc ccc gtt atc agc agc aag aac tgg ctg cga ctg cac ttc aca tcg 625 Ala Pro Val Ile Ser Ser Lys Asn Trp Leu Arg Leu His Phe Thr Ser 195 200 205 gat ggc aac cac cgg cag cgc gga ttc agt gcc caa tac caa gtc aag 673 Asp Gly Asn His Arg Gln Arg Gly Phe Ser Ala Gln Tyr Gln Val Lys 210 215 220 aag caa att gag ttg aag tct cga ggt gtg aag ctg atg ccc agc aaa 721 Lys Gln Ile Glu Leu Lys Ser Arg Gly Val Lys Leu Met Pro Ser Lys 225 230 235 240 gac aac agc cag aag acg tct gtg tgt aag tgt ccg ccc gcc agc ccg 769 Asp Asn Ser Gln Lys Thr Ser Val Cys Lys Cys Pro Pro Ala Ser Pro 245 250 255 cct gcc ggg cct ctt gct tgaggtcaca cgtgcaggca ctaaaccgtg 817 Pro Ala Gly Pro Leu Ala 260 gggaagccag atgatgctgg aatgactttc cttcaaccct gcttcctcca tcctgggctc 877 tgcgcttgga cacactgacc caacggccag agagcagccc tggggcctgc cctttgcctt 937 ctcctcctcc tcgtcccatt ttcctccttg tcctctttct ccctcacttc gcatttgaac 997 tgcagtccag ggagtcatta ctgctacatt tctctcttta ttttcctttt gaatcacttc 1057 cacctgctaa gacagtcctc cttcagctcc tcttttagga gtcagtaacc ttgggctggg 1117 atcttggggg ctgtagggcc ccagttccag ctcccaaggc cagattggga aagggaggca 1177 ggggaatgcc tagtaacctc ctccaagggc ccctggacct ggctgagcaa agagaggact 1237 ggggaagtgt gggggtgggt cctgcctcgg ggcgatgggg aggcactggg gggctctctt 1297 cttgggcgtg gggaggatga catctttcag aacatgttcc tgctaccagt gtttgtaagg 1357 ttaatagggg tctagttctg gggaatggtc tggaatgtgg gtcccagaaa cacctgatca 1417 gggcctgtgc taaggggctt ttgagctgaa gcccaggaag ggctggggaa ggttctgggc 1477 acctccacaa gactgggctt aaaagcaggg gaggtttttt tccagaaacc ttccactttc 1537 cttctgggcc gagtggtagg gagccttcct tggtcctcca aatgactgac ctggttttcc 1597 ttctccttcc ctccctttgc ccttctcctg catctctggt cctctctccc ttcacttttt 1657 ctcctcttgc cactttctgc tccatcgttc ttctcatcct tctgctcccg cctcttctct 1717 ccctgcttgt cttcctgtcc ctgacttgct cctcccaccc tccccattcc tccccttcca 1777 tctcacctcc atgtgctcac tttcctggag atgctagaag tacttattga ggagagaagg 1837 gcatagagtg gcaccggtgg ttttcgagct ctgtgccgat gtgtgtggcc gggagaacat 1897 caggagaaga ggcactttgg tctcatgatc cgactgaacc gagcctgggt tggggattgt 1957 ctgtggtctt tgaagttgtc tgagtggaga cagttgccac aggctgttgg atacagccag 2017 gaactggcat ctccagtcac caccctcagg gactggatgg cagagggcac cagaagagcc 2077 ttcttctgtg cttgactggg ggtttagggg aaaggacagg gtgctaggag agcccagggt 2137 caggccagga acctgcagag ggctcaagcc atggccctga ccctcacagg ctttttcttt 2197 ctgtagccac aggagaccca atgaactgag gcaggcacag tttaatttca cagtttgccc 2257 tggagccaca ggcaaactta aggaaatggc cctgacttgg gagatcaaat atttatccca 2317 actgtgtcct cagggagcat gttaccccag acactaatgt ttcagttttc acatctgtag 2377 aatggggatg caaaatccta ccctgccttc ctcccaagag tgttgccaga tctaagatgg 2437 gtcttgttga cctaggactt caggaggccc atggactagc caaaaaagta catgtgatgc 2497 tctgggtgca tttttctgga gacaggatgc agggttttca ttaagccgac taagaagatg 2557 ccaaaaactc cctcaggaag ataaagagaa accctgttct aatgaaagaa tgcaaatgct 2617 ctttgcaaaa taaatatata tatctctatt gagaagatat tagcctccat tctaagagtt 2677 cctcagaaag aatgggtgtg tgactccagc tgcctcagac ccaggtagcc acatgtctgc 2737 aggtggctgg cctcctgtgt tctgcccaaa ttccctgtgg acagctgccc tgaagttcat 2797 ggggagagtg gacccaactc tctacctagc catcagttct gaccacccac ccacctgtga 2857 ctccctgcgt tgggtagaag gtggtgcctt cctgagcaca ttgcggcttc tccctcgcca 2917 tagtggccct cccagagtag agtaaggatt actccccatt cctgtccctc agtagccaac 2977 aggaaagcaa tgctgtaaac acaagcagct ggttttgagt aggcagagaa gactggaatt 3037 <210> 20 <211> 2883 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3)..(1967) <400> 20 cc ttg tat gca ggg cag cgt ctg ccc caa cat ggg tat cct ggg cct 47 Leu Tyr Ala Gly Gln Arg Leu Pro Gln His Gly Tyr Pro Gly Pro 1 5 10 15 ccc cag gcc cag cca ctg ccc cga cag ggg gtc aag aga acc tac tct 95 Pro Gln Ala Gln Pro Leu Pro Arg Gln Gly Val Lys Arg Thr Tyr Ser 20 25 30 gag gtg tat cca ggg cag cag tat ctg caa gga ggc cag tat gca ccc 143 Glu Val Tyr Pro Gly Gln Gln Tyr Leu Gln Gly Gly Gln Tyr Ala Pro 35 40 45 agc acc gcc cag ttt gcg ccc agc cct ggg cag ccc cct gcc ccc tcc 191 Ser Thr Ala Gln Phe Ala Pro Ser Pro Gly Gln Pro Pro Ala Pro Ser 50 55 60 cct tcc tac cct ggg cac agg ctg ccc ctg cag cag ggc atg acc cag 239 Pro Ser Tyr Pro Gly His Arg Leu Pro Leu Gln Gln Gly Met Thr Gln 65 70 75 tcc ctg tcc gtg cct ggc ccc acg gga ctg cat tat aag cct acc cgt 287 Ser Leu Ser Val Pro Gly Pro Thr Gly Leu His Tyr Lys Pro Thr Arg 80 85 90 95 tcc atc ccg ggc tat ccc agt tcc cca ctg cca ggg aac ccc acg cca 335 Ser Ile Pro Gly Tyr Pro Ser Ser Pro Leu Pro Gly Asn Pro Thr Pro 100 105 110 ccc atg acc cca agc agc agc gtc cct tac atg tca cca aac caa gag 383 Pro Met Thr Pro Ser Ser Ser Val Pro Tyr Met Ser Pro Asn Gln Glu 115 120 125 gtc aag tct ccc ttc ttg cct gat ctc aag ccc aac ctc aac tcc ttg 431 Val Lys Ser Pro Phe Leu Pro Asp Leu Lys Pro Asn Leu Asn Ser Leu 130 135 140 cac tca tcg ccc tct gga agc ggg cct tgt gac gag ttg cgg ctg acc 479 His Ser Ser Pro Ser Gly Ser Gly Pro Cys Asp Glu Leu Arg Leu Thr 145 150 155 ttc cct gtg cgc gat ggg gtg gtc ctg gag ccc ttc cgc ctg cag cac 527 Phe Pro Val Arg Asp Gly Val Val Leu Glu Pro Phe Arg Leu Gln His 160 165 170 175 aac ctg gct gta agc aac cat gtc ttc cag ctg cga gac tca gtc tac 575 Asn Leu Ala Val Ser Asn His Val Phe Gln Leu Arg Asp Ser Val Tyr 180 185 190 aag acc ctg ata atg agg cct gac ctg gag ctg caa ttc aag tgc tac 623 Lys Thr Leu Ile Met Arg Pro Asp Leu Glu Leu Gln Phe Lys Cys Tyr 195 200 205 cac cac gag gac cgg cag atg aac acc aac tgg cca gcc tcg gtg cag 671 His His Glu Asp Arg Gln Met Asn Thr Asn Trp Pro Ala Ser Val Gln 210 215 220 gtc agc gtc aat gcc acg ccg ctc acc atc gag cgt ggc gac aac aag 719 Val Ser Val Asn Ala Thr Pro Leu Thr Ile Glu Arg Gly Asp Asn Lys 225 230 235 acc tcg cac aag cca ctc tac ctg aag cat gtg tgc cag cca ggc cgc 767 Thr Ser His Lys Pro Leu Tyr Leu Lys His Val Cys Gln Pro Gly Arg 240 245 250 255 aac acc atc cag atc acc gtc acc gcc tgc tgc tgc tcc cac ctc ttc 815 Asn Thr Ile Gln Ile Thr Val Thr Ala Cys Cys Cys Ser His Leu Phe 260 265 270 gtg ctg cag cta gtg cac cgc cca tcc gtc cgc tcg gtg ctg cag ggc 863 Val Leu Gln Leu Val His Arg Pro Ser Val Arg Ser Val Leu Gln Gly 275 280 285 ctc ctc aaa aag cgc ctc ctg cct gct gag cac tgc atc acc aag ata 911 Leu Leu Lys Lys Arg Leu Leu Pro Ala Glu His Cys Ile Thr Lys Ile 290 295 300 aag cgg aac ttc agc agc ggc acc atc cct ggc acc cct ggg ccc aac 959 Lys Arg Asn Phe Ser Ser Gly Thr Ile Pro Gly Thr Pro Gly Pro Asn 305 310 315 gga gag gac ggg gtg gag cag aca gct atc aag gtg tcc ctg aag tgc 1007 Gly Glu Asp Gly Val Glu Gln Thr Ala Ile Lys Val Ser Leu Lys Cys 320 325 330 335 ccc atc acc ttc cgc agg atc cag ctc cct gcc cga ggt cat gac tgt 1055 Pro Ile Thr Phe Arg Arg Ile Gln Leu Pro Ala Arg Gly His Asp Cys 340 345 350 cgc cac ata cag tgc ttt gac ctg gag tcg tac ctg cag ctc aac tgt 1103 Arg His Ile Gln Cys Phe Asp Leu Glu Ser Tyr Leu Gln Leu Asn Cys 355 360 365 gag cgg ggg act tgg agg tgt cct gtg tgc aac aag aca gct ttg ctg 1151 Glu Arg Gly Thr Trp Arg Cys Pro Val Cys Asn Lys Thr Ala Leu Leu 370 375 380 gag ggc ctg gag gtg gac cag tac atg ctg ggc atc ctg att tac att 1199 Glu Gly Leu Glu Val Asp Gln Tyr Met Leu Gly Ile Leu Ile Tyr Ile 385 390 395 cag aac tct gac tat gag gag atc acc atc gac ccc acg tgc agc tgg 1247 Gln Asn Ser Asp Tyr Glu Glu Ile Thr Ile Asp Pro Thr Cys Ser Trp 400 405 410 415 aag cca gtg ccc gtg aag cct gac atg cac atc aag gag gag ccg gat 1295 Lys Pro Val Pro Val Lys Pro Asp Met His Ile Lys Glu Glu Pro Asp 420 425 430 ggg cca gca ctg aag cgc tgc cgc acc gtg agc ccc gcc cac gtg ctc 1343 Gly Pro Ala Leu Lys Arg Cys Arg Thr Val Ser Pro Ala His Val Leu 435 440 445 atg ccc agc gtg atg gag atg atc gcc gcc ctg ggc ccc ggc gct gcc 1391 Met Pro Ser Val Met Glu Met Ile Ala Ala Leu Gly Pro Gly Ala Ala 450 455 460 ccc ttt gcc ccc ctg cag ccc ccc tca gtc cct gcc ccc agc gac tac 1439 Pro Phe Ala Pro Leu Gln Pro Pro Ser Val Pro Ala Pro Ser Asp Tyr 465 470 475 cct ggc cag ggt tcc agc ttc ctg ggg cct gga act ttc cct gag tcc 1487 Pro Gly Gln Gly Ser Ser Phe Leu Gly Pro Gly Thr Phe Pro Glu Ser 480 485 490 495 ttc cca ccc acc atg ccc agc acc cca acc ctt gct gag ttc acc ccg 1535 Phe Pro Pro Thr Met Pro Ser Thr Pro Thr Leu Ala Glu Phe Thr Pro 500 505 510 gga cca ccc ccc atc tcc tac cag tct gac att ccc agc agc ctc ctg 1583 Gly Pro Pro Pro Ile Ser Tyr Gln Ser Asp Ile Pro Ser Ser Leu Leu 515 520 525 act tca gag aag tct acc gcc tgc ctc cca agc cag atg gca cca gca 1631 Thr Ser Glu Lys Ser Thr Ala Cys Leu Pro Ser Gln Met Ala Pro Ala 530 535 540 ggt cac ctg gac ccc act cac aat cct ggg aca cca gga cta cac acc 1679 Gly His Leu Asp Pro Thr His Asn Pro Gly Thr Pro Gly Leu His Thr 545 550 555 tcc aac ctt ggg gcc cct cca ggt ccc cag ctg cac cat tca aac cct 1727 Ser Asn Leu Gly Ala Pro Pro Gly Pro Gln Leu His His Ser Asn Pro 560 565 570 575 ccc cca gcg tcc cgg cag tcc ttg ggc caa gcg agc tta gga cct acg 1775 Pro Pro Ala Ser Arg Gln Ser Leu Gly Gln Ala Ser Leu Gly Pro Thr 580 585 590 ggt gaa ctg gcc ttc agt cct gcc aca ggc gtg atg ggg ccc ccc agc 1823 Gly Glu Leu Ala Phe Ser Pro Ala Thr Gly Val Met Gly Pro Pro Ser 595 600 605 atg tct gga gcc ggg gag gcc cca gaa cca gct ctg gac ctg ctc ccg 1871 Met Ser Gly Ala Gly Glu Ala Pro Glu Pro Ala Leu Asp Leu Leu Pro 610 615 620 gaa ctg acc aac cct gat gag cta ctg tcc tac ttg ggc cca ccc gac 1919 Glu Leu Thr Asn Pro Asp Glu Leu Leu Ser Tyr Leu Gly Pro Pro Asp 625 630 635 ctc cct acg aac aac aat gac gac ctg ctt tct ctg ttt gag aac aac 1967 Leu Pro Thr Asn Asn Asn Asp Asp Leu Leu Ser Leu Phe Glu Asn Asn 640 645 650 655 tgatcctgtg tttaccccaa gcccggcggg gacacgctca cagatgtcac cacagccctg 2027 cccttcatgc ccagccccat gggacacccg gtggtctttc ccaaacctcc cccaaaacac 2087 acctggagcc agagccttct gccgccagcc ctgcccctga attggaagca gccctgtgct 2147 cgatgggagg ggctcccagg ccggcagccc ttgccacctc cctctgccaa gcctgctgct 2207 gcagaacggt ttttgctgag gtgcccctgc ccagccctgt ccagccttgt ccacacacac 2267 atctcacgcc cctggtctca cagcctcaca ccttgtcctt ccacccctgc ctgcccccac 2327 ccagcctgct tcttgtccag cattgatcct tctgtttcaa caactcctcc actgggcaga 2387 gctgggcatc tggcagggct ggctctgtcc cctgggcctt tggctccagt ggcccctgtg 2447 cccagcagtc cagctcttgg aacctcgctg aatggcagcc tcttgggggc ctggagctct 2507 ggcagcccag ccgtgtgtgg tgtcaggttc ctctccccac cccagcttca agcagaggcc 2567 tcggggtggg ggagctacaa agcacaacaa tgtacatagt gtagaaacac taacagctgg 2627 gagaggggag ccagctgtcc agccagcatg ttcctgttgt acagcccggt ctccctgcgc 2687 gctctgctcc ttcccatgtg cagacagatc agggaggaac ctccaatggg tgggggacag 2747 tgagcttcgg cctggccgag gtgggtgggt gggctctcag attcagctct gtgtaaagat 2807 tctctagcgg gctgcgctcc caagttcccc ttctctgtga aagtgaagaa ttagtacagc 2867 tgtgtttttt aaagcc 2883 <210> 21 <211> 3441 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(1516) <400> 21 c ggg ctc acg ctc ttc ttc gtg gtg ctc ggc tct ctg tcg gtg caa gtg 49 Gly Leu Thr Leu Phe Phe Val Val Leu Gly Ser Leu Ser Val Gln Val 1 5 10 15 ttc agc ttc cgc tgg ttt gtg cac gat ttc agc acc gag gac agc gcc 97 Phe Ser Phe Arg Trp Phe Val His Asp Phe Ser Thr Glu Asp Ser Ala 20 25 30 acg gcc gct gct gcc tcc agc tgc ccg cag cct gga gcc gat tgc aag 145 Thr Ala Ala Ala Ala Ser Ser Cys Pro Gln Pro Gly Ala Asp Cys Lys 35 40 45 acg gtg gtc ggc ggt ggg tct gca gcc ggg gaa ggc gag gct cgt cct 193 Thr Val Val Gly Gly Gly Ser Ala Ala Gly Glu Gly Glu Ala Arg Pro 50 55 60 tcc acg ccg caa agg caa gca tct aac gcc agc aag agc aac atc gcc 241 Ser Thr Pro Gln Arg Gln Ala Ser Asn Ala Ser Lys Ser Asn Ile Ala 65 70 75 80 gcg gcc aac agc ggc agc aac agc agc ggg gct acc cgg gcc agt ggc 289 Ala Ala Asn Ser Gly Ser Asn Ser Ser Gly Ala Thr Arg Ala Ser Gly 85 90 95 aag cac agg tct gcg tcc tgc tcc ttc tgc atc tgg ctc ctg cag tca 337 Lys His Arg Ser Ala Ser Cys Ser Phe Cys Ile Trp Leu Leu Gln Ser 100 105 110 ctc atc cac atc ttg cag ctc ggg caa atc tgg aga tat ttc cac aca 385 Leu Ile His Ile Leu Gln Leu Gly Gln Ile Trp Arg Tyr Phe His Thr 115 120 125 ata tac tta ggt att cga agc cga cag agt ggg gag aat gac aga tgg 433 Ile Tyr Leu Gly Ile Arg Ser Arg Gln Ser Gly Glu Asn Asp Arg Trp 130 135 140 agg ttt tac tgg aaa atg gta tat gag tat gcg gat gtg agt atg ctg 481 Arg Phe Tyr Trp Lys Met Val Tyr Glu Tyr Ala Asp Val Ser Met Leu 145 150 155 160 cat ttg cta gcc acc ttt ctg gaa agt gct cca cag ctg gtc ctg cag 529 His Leu Leu Ala Thr Phe Leu Glu Ser Ala Pro Gln Leu Val Leu Gln 165 170 175 ctc tgc att atc gta cag act cat agc tta cag gcc ctc caa ggt ttc 577 Leu Cys Ile Ile Val Gln Thr His Ser Leu Gln Ala Leu Gln Gly Phe 180 185 190 aca gcg gca gct tcc ctc gtg tcc ctg gcc tgg gcc ttg gcc tcc tac 625 Thr Ala Ala Ala Ser Leu Val Ser Leu Ala Trp Ala Leu Ala Ser Tyr 195 200 205 cag aag gcc ctc cgg gac tct cga gat gac aag aag ccc atc agc tac 673 Gln Lys Ala Leu Arg Asp Ser Arg Asp Asp Lys Lys Pro Ile Ser Tyr 210 215 220 atg gcc gtc atc atc cag ttc tgc tgg cac ttc ttc acc atc gcc gcc 721 Met Ala Val Ile Ile Gln Phe Cys Trp His Phe Phe Thr Ile Ala Ala 225 230 235 240 agg gtc atc acg ttt gcc ctc ttt gcc tcg gtt ttc cag ctg tac ttt 769 Arg Val Ile Thr Phe Ala Leu Phe Ala Ser Val Phe Gln Leu Tyr Phe 245 250 255 ggg atc ttc atc gtc ctt cac tgg tgc atc atg acc ttc tgg atc gtc 817 Gly Ile Phe Ile Val Leu His Trp Cys Ile Met Thr Phe Trp Ile Val 260 265 270 cac tgt gag aca gaa ttc tgt atc acc aaa tgg gaa gag att gtg ttc 865 His Cys Glu Thr Glu Phe Cys Ile Thr Lys Trp Glu Glu Ile Val Phe 275 280 285 gac atg gtg gtg ggg att atc tat atc ttc agt tgg ttc aat gtc aag 913 Asp Met Val Val Gly Ile Ile Tyr Ile Phe Ser Trp Phe Asn Val Lys 290 295 300 gaa ggc agg aca cgc tgc agg cta ttc att tac tat ttt gtg atc ctt 961 Glu Gly Arg Thr Arg Cys Arg Leu Phe Ile Tyr Tyr Phe Val Ile Leu 305 310 315 320 ttg gaa aat aca gcc ttg agt gcc ctc tgg tac ctc tac aag gct ccc 1009 Leu Glu Asn Thr Ala Leu Ser Ala Leu Trp Tyr Leu Tyr Lys Ala Pro 325 330 335 cag att gca gac gca ttt gcc att cca gcg ctg tgt gtg gtg ttc agc 1057 Gln Ile Ala Asp Ala Phe Ala Ile Pro Ala Leu Cys Val Val Phe Ser 340 345 350 agc ttt tta act ggc gtt gtt ttt atg ctg atg tat tat gcc ttc ttt 1105 Ser Phe Leu Thr Gly Val Val Phe Met Leu Met Tyr Tyr Ala Phe Phe 355 360 365 cat ccc aat gga ccc aga ttc ggg cag tca cca agt tgt gct tgt gag 1153 His Pro Asn Gly Pro Arg Phe Gly Gln Ser Pro Ser Cys Ala Cys Glu 370 375 380 gac cca gcc gct gcc ttc act ttg ccc cca gac gtg gcc aca agc acc 1201 Asp Pro Ala Ala Ala Phe Thr Leu Pro Pro Asp Val Ala Thr Ser Thr 385 390 395 400 cta cgg tcc atc tcc aac aac cgc agt gtt gtc agc gac cgc gat cag 1249 Leu Arg Ser Ile Ser Asn Asn Arg Ser Val Val Ser Asp Arg Asp Gln 405 410 415 aaa ttc gca gag cgg gat ggg tgt gta cct gtc ttt caa gtg agg ccc 1297 Lys Phe Ala Glu Arg Asp Gly Cys Val Pro Val Phe Gln Val Arg Pro 420 425 430 act gcc cca tcc acc cca tca tct cgc cca cca cgg att gaa gaa tca 1345 Thr Ala Pro Ser Thr Pro Ser Ser Arg Pro Pro Arg Ile Glu Glu Ser 435 440 445 gtc att aaa att gac ttg ttc agg aat agg tac cca gca tgg gag aga 1393 Val Ile Lys Ile Asp Leu Phe Arg Asn Arg Tyr Pro Ala Trp Glu Arg 450 455 460 cat gtt ttg gac cga agc ctc cga aag gct att tta gct ttt gaa tgt 1441 His Val Leu Asp Arg Ser Leu Arg Lys Ala Ile Leu Ala Phe Glu Cys 465 470 475 480 tcc cca tct cct cca agg ctg cag tac aaa gat gat gcc ctt att cag 1489 Ser Pro Ser Pro Pro Arg Leu Gln Tyr Lys Asp Asp Ala Leu Ile Gln 485 490 495 gag cgg ttg gag tac gaa acc act tta taaagcaaaa ggagttgcag 1536 Glu Arg Leu Glu Tyr Glu Thr Thr Leu 500 505 gacccacaac atccagatga aggggtgaca gcagggctgt ggccataatg acacttcatc 1596 ctagagcagg gcagtgagcc gtgaagttcc tagtgggacc gtcatcacca ttatcatttg 1656 atcctgtcgg ctgggggcgg ctggtctcct tccaaagcag ctgcacccga gagtctctga 1716 ctccacctga aagaatgacg ctggcttaat aggactctcc attgctacca aactcctcct 1776 gcacggtctt gggtgcaccc accagagggt actactatta tggaaaaatt ttgcctccaa 1836 tcattagggt gtcttgatgg cgttaactga tctttccata aaaatagatt cagtcataca 1896 cacatacaca cactaacaca cataagttac accagtcctc tgtcaaaaaa gcttaggtga 1956 cttttcttga tgcaaagctc tgattcccac aggaatataa aaacaaagaa agagggaaac 2016 atccctcgag aaaaaaaata gtattgctta gaaaagaaac cattttctca tttggaaatc 2076 cataccatgt gtgaaaatcc tatccaacgg acagcaaacc caaatgttgt ctacacatgt 2136 gttagcattg atggagtggt tcattttcta cacatttcag gatttgtttt atattttaaa 2196 ttttcagttg cgaacatcct ttttgacaga aatcctatgc agcccatgta cggctttcaa 2256 caagaccaag gagctcaata acttcatgat gtaaattaaa tagtaatcat gattcagtat 2316 tcaattgcaa aaatgtaaca ggtacacaaa gaggaagtgg ggaaaaaggc aaaatgagag 2376 tctgattccc aggcatgtgc agcgcccatt gggacataac ggcagtgcgg cgcgagccag 2436 aggaatgggc tggaaccgga tctgtttcca gacgcagaat gagtggctct gtgtgaccat 2496 aggcagatgc tgactctgga agactccgtg ccactccttt ctagtgccaa acaccatcca 2556 accacaggac tgacgtggaa gccccaaaca actgagaatg agtggcatga gccccctaaa 2616 agcaggcgag agaacgagca atcaagttct ccactgtgta cagacttttc ctccccccaa 2676 tccaaggtca aagtgatgtg tcttttagag gctttgggac actttttagt aagtatgagc 2736 agacaaatgc aatgaatatg ctatgaaaaa acccttctga actgagagag ggcttatcac 2796 tatatccagc taagatttgt atttgaatca tctgtaaagt cgcactctta caacaagctt 2856 ctgggtttta aatacctccg tacagcaagt aaacgttccc cgctttctgt tctcagtgtc 2916 ctcggtcatg gtgcttttcg ttgcattaaa agtgccggtc aaactttgat agtatttttt 2976 tatagttggt gcagagtgga ataactcatg gattatttca atatttttgt aataaaaaat 3036 atagggtata cacataggca tcatcacatt ttttatagac ctggaatcgt ttaaaatact 3096 ttaagcatca taattacttg ggatgtcaga aactggtcca caaattccat cagcctgcct 3156 cagcagattg aaaacatttg tctcttgcaa gatcacccta ctttgcaagt tggtgccccc 3216 aggaacctgg ccaggggtgc tatcagaata tcaggtgaag agagaatcag cttaaataga 3276 aagggcttgt caagactggc caatgtttcc caggaaatca aagatgtaaa tgattacttt 3336 catccatcca ttataacaaa cctgaccaca gtggaagctg tcttaaactt ccttccctgg 3396 ttttatatta acccaactga tagattaagt attagtcaaa ccact 3441 <210> 22 <211> 3289 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(3144) <400> 22 ggg aaa gga gtt caa atg atc ttt cac acc ttt cat ctt gag agt tcc 48 Gly Lys Gly Val Gln Met Ile Phe His Thr Phe His Leu Glu Ser Ser 1 5 10 15 cac gac tat tta ctg atc aca gag gat gga agt ttt tcc gag ccc gtt 96 His Asp Tyr Leu Leu Ile Thr Glu Asp Gly Ser Phe Ser Glu Pro Val 20 25 30 gcc agg ctc acc ggg tcg gtg ttg cct cat acg atc aag gca ggc ctg 144 Ala Arg Leu Thr Gly Ser Val Leu Pro His Thr Ile Lys Ala Gly Leu 35 40 45 ttt gga aac ttc act gcc cag ctt cgg ttt ata tca gac ttc tca att 192 Phe Gly Asn Phe Thr Ala Gln Leu Arg Phe Ile Ser Asp Phe Ser Ile 50 55 60 tcg tac gag ggc ttc aat atc aca ttt tca gaa tat gac ctg gag cca 240 Ser Tyr Glu Gly Phe Asn Ile Thr Phe Ser Glu Tyr Asp Leu Glu Pro 65 70 75 80 tgt gat gat cct gga gtc cct gcc ttc agc cga aga att ggt ttt cac 288 Cys Asp Asp Pro Gly Val Pro Ala Phe Ser Arg Arg Ile Gly Phe His 85 90 95 ttt ggt gtg gga gac tct ctg acg ttt tcc tgc ttc ctg gga tat cgt 336 Phe Gly Val Gly Asp Ser Leu Thr Phe Ser Cys Phe Leu Gly Tyr Arg 100 105 110 tta gaa ggt gcc acc aag ctt acc tgc ctg ggt ggg ggc cgc cgt gtg 384 Leu Glu Gly Ala Thr Lys Leu Thr Cys Leu Gly Gly Gly Arg Arg Val 115 120 125 tgg agt gca cct ctg cca agg tgt gtg gcc gaa tgt gga gca agt gtc 432 Trp Ser Ala Pro Leu Pro Arg Cys Val Ala Glu Cys Gly Ala Ser Val 130 135 140 aaa gga aat gaa gga aca tta ctg tct cca aat ttt cca tcc aat tat 480 Lys Gly Asn Glu Gly Thr Leu Leu Ser Pro Asn Phe Pro Ser Asn Tyr 145 150 155 160 gat aat aac cat gag tgt atc tat aaa ata gaa aca gaa gcc ggc aag 528 Asp Asn Asn His Glu Cys Ile Tyr Lys Ile Glu Thr Glu Ala Gly Lys 165 170 175 ggc atc cac ctt aga aca cga agc ttc cag ctg ttt gaa gga gat act 576 Gly Ile His Leu Arg Thr Arg Ser Phe Gln Leu Phe Glu Gly Asp Thr 180 185 190 cta aag gta tat gat gga aaa gac agt tcc tca cgt cca ctg ggc acg 624 Leu Lys Val Tyr Asp Gly Lys Asp Ser Ser Ser Arg Pro Leu Gly Thr 195 200 205 ttc act aaa aat gaa ctt ctg ggg ctg atc cta aac agc aca tcc aat 672 Phe Thr Lys Asn Glu Leu Leu Gly Leu Ile Leu Asn Ser Thr Ser Asn 210 215 220 cac cta tgg cta gag ttc aac acc aat gga tct gac acc gac caa ggt 720 His Leu Trp Leu Glu Phe Asn Thr Asn Gly Ser Asp Thr Asp Gln Gly 225 230 235 240 ttt caa ctc acc tat acc agt ttt gat ctg gta aaa tgt gag gat ccg 768 Phe Gln Leu Thr Tyr Thr Ser Phe Asp Leu Val Lys Cys Glu Asp Pro 245 250 255 ggc atc cct aac tac ggc tat agg atc cgt gat gaa ggc cac ttt acc 816 Gly Ile Pro Asn Tyr Gly Tyr Arg Ile Arg Asp Glu Gly His Phe Thr 260 265 270 gac act gta gtt ctg tac agt tgc aac ccg ggg tac gcc atg cat ggc 864 Asp Thr Val Val Leu Tyr Ser Cys Asn Pro Gly Tyr Ala Met His Gly 275 280 285 agc aac acc ctg acc tgt ttg agt gga gac agg aga gtg tgg gac aaa 912 Ser Asn Thr Leu Thr Cys Leu Ser Gly Asp Arg Arg Val Trp Asp Lys 290 295 300 cca cta cct tcg tgc ata gcg gaa tgt ggt ggt cag atc cat gca gcc 960 Pro Leu Pro Ser Cys Ile Ala Glu Cys Gly Gly Gln Ile His Ala Ala 305 310 315 320 aca tca gga cga ata ttg tcc cct ggc tat cca gct ccg tat gac aac 1008 Thr Ser Gly Arg Ile Leu Ser Pro Gly Tyr Pro Ala Pro Tyr Asp Asn 325 330 335 aac ctc cac tgc acc tgg att ata gag gca gac cca gga aag acc att 1056 Asn Leu His Cys Thr Trp Ile Ile Glu Ala Asp Pro Gly Lys Thr Ile 340 345 350 agc ctc cat ttc att gtt ttc gac acg gag atg gct cac gac atc ctc 1104 Ser Leu His Phe Ile Val Phe Asp Thr Glu Met Ala His Asp Ile Leu 355 360 365 aag gtc tgg gac ggg ccg gtg gac agt gac atc ctg ctg aag gag tgg 1152 Lys Val Trp Asp Gly Pro Val Asp Ser Asp Ile Leu Leu Lys Glu Trp 370 375 380 agt ggc tcc gcc ctt ccg gag gac atc cac agc acc ttc aac tca ctc 1200 Ser Gly Ser Ala Leu Pro Glu Asp Ile His Ser Thr Phe Asn Ser Leu 385 390 395 400 acc ctg cag ttc gac agc gac ttc ttc atc agc aag tct ggc ttc tcc 1248 Thr Leu Gln Phe Asp Ser Asp Phe Phe Ile Ser Lys Ser Gly Phe Ser 405 410 415 atc cag ttc tcc acc tca att gca gcc acc tgt aac gat cca ggt atg 1296 Ile Gln Phe Ser Thr Ser Ile Ala Ala Thr Cys Asn Asp Pro Gly Met 420 425 430 ccc caa aat ggc acc cgc tat gga gac agc aga gag gct gga gac acc 1344 Pro Gln Asn Gly Thr Arg Tyr Gly Asp Ser Arg Glu Ala Gly Asp Thr 435 440 445 gtc aca ttc cag tgt gac cct ggc tat cag ctc caa gga caa gcc aaa 1392 Val Thr Phe Gln Cys Asp Pro Gly Tyr Gln Leu Gln Gly Gln Ala Lys 450 455 460 atc acc tgt gtg cag ctg aat aac cgg ttc ttt tgg caa cca gac cct 1440 Ile Thr Cys Val Gln Leu Asn Asn Arg Phe Phe Trp Gln Pro Asp Pro 465 470 475 480 cct aca tgc ata gct gct tgt gga ggg aat ctg acg ggc cca gca ggt 1488 Pro Thr Cys Ile Ala Ala Cys Gly Gly Asn Leu Thr Gly Pro Ala Gly 485 490 495 gtt att ttg tca ccc aac tac cca cag ccg tat cct cct ggg aag gaa 1536 Val Ile Leu Ser Pro Asn Tyr Pro Gln Pro Tyr Pro Pro Gly Lys Glu 500 505 510 tgt gac tgg aga gta aaa gtg aac ccg gac ttt gtc atc gcc ttg ata 1584 Cys Asp Trp Arg Val Lys Val Asn Pro Asp Phe Val Ile Ala Leu Ile 515 520 525 ttc aaa agt ttc aac atg gag ccc agc tat gac ttc cta cac atc tat 1632 Phe Lys Ser Phe Asn Met Glu Pro Ser Tyr Asp Phe Leu His Ile Tyr 530 535 540 gaa ggg gaa gat tcc aac agc ccc ctc att ggg agt tac cag ggc tct 1680 Glu Gly Glu Asp Ser Asn Ser Pro Leu Ile Gly Ser Tyr Gln Gly Ser 545 550 555 560 cag gcc cca gaa aga ata gag agt agc gga aac agc ctg ttt ctg gca 1728 Gln Ala Pro Glu Arg Ile Glu Ser Ser Gly Asn Ser Leu Phe Leu Ala 565 570 575 ttt cgg agt gat gcc tcc gtg ggc ctt tca ggg ttc gcc att gaa ttt 1776 Phe Arg Ser Asp Ala Ser Val Gly Leu Ser Gly Phe Ala Ile Glu Phe 580 585 590 aaa gag aaa cca cgg gaa gct tgt ttt gac cca gga aat ata atg aat 1824 Lys Glu Lys Pro Arg Glu Ala Cys Phe Asp Pro Gly Asn Ile Met Asn 595 600 605 ggg aca aga gtt gga aca gac ttc aag ctt ggc tcc acc atc acc tac 1872 Gly Thr Arg Val Gly Thr Asp Phe Lys Leu Gly Ser Thr Ile Thr Tyr 610 615 620 cag tgt gac tct ggc tat aag att ctt gac ccc tca tcc atc acc tgt 1920 Gln Cys Asp Ser Gly Tyr Lys Ile Leu Asp Pro Ser Ser Ile Thr Cys 625 630 635 640 gtg att ggg gct gat ggg aaa ccc tcc tgg gac caa gtg ctg ccc tcc 1968 Val Ile Gly Ala Asp Gly Lys Pro Ser Trp Asp Gln Val Leu Pro Ser 645 650 655 tgc aat gct ccc tgt gga ggc cag tac acg gga tca gaa ggg gta gtt 2016 Cys Asn Ala Pro Cys Gly Gly Gln Tyr Thr Gly Ser Glu Gly Val Val 660 665 670 tta tca cca aac tac ccc cat aat tac aca gct ggt caa ata tgc ctc 2064 Leu Ser Pro Asn Tyr Pro His Asn Tyr Thr Ala Gly Gln Ile Cys Leu 675 680 685 tat tcc atc acg gta cca aag gaa ttc gtg gtc ttt gga cag ttt gcc 2112 Tyr Ser Ile Thr Val Pro Lys Glu Phe Val Val Phe Gly Gln Phe Ala 690 695 700 tat ttc cag aca gcc ctg aat gat ttg gca gaa tta ttt gat gga acc 2160 Tyr Phe Gln Thr Ala Leu Asn Asp Leu Ala Glu Leu Phe Asp Gly Thr 705 710 715 720 cat gca cag gcc aga ctt ctc agc tca ctc tcg ggg tct cac tca ggg 2208 His Ala Gln Ala Arg Leu Leu Ser Ser Leu Ser Gly Ser His Ser Gly 725 730 735 gaa aca ttg ccc ttg gct acg tca aat caa att ctg ctc cga ttc agt 2256 Glu Thr Leu Pro Leu Ala Thr Ser Asn Gln Ile Leu Leu Arg Phe Ser 740 745 750 gca aag agc ggt gcc tct gcc cgc ggc ttc cac ttc gtg tat caa gct 2304 Ala Lys Ser Gly Ala Ser Ala Arg Gly Phe His Phe Val Tyr Gln Ala 755 760 765 gtt cct cgt acc agt gac acc caa tgc agc tct gtc ccc gag ccc aga 2352 Val Pro Arg Thr Ser Asp Thr Gln Cys Ser Ser Val Pro Glu Pro Arg 770 775 780 tac gga agg aga att ggt tct gag ttt tct gcc ggc tcc atc gtc cga 2400 Tyr Gly Arg Arg Ile Gly Ser Glu Phe Ser Ala Gly Ser Ile Val Arg 785 790 795 800 ttc gag tgc aac ccg gga tac ctg ctt cag ggt tcc acg gcg ctc cac 2448 Phe Glu Cys Asn Pro Gly Tyr Leu Leu Gln Gly Ser Thr Ala Leu His 805 810 815 tgc cag tcc gtg ccc aac gcc ttg gca cag tgg aac gac acg atc ccc 2496 Cys Gln Ser Val Pro Asn Ala Leu Ala Gln Trp Asn Asp Thr Ile Pro 820 825 830 agc tgt gtg gta ccc tgc agt ggc aat ttc act caa cga aga ggt aca 2544 Ser Cys Val Val Pro Cys Ser Gly Asn Phe Thr Gln Arg Arg Gly Thr 835 840 845 atc ctg tcc ccc ggc tac cct gag cca tac gga aac aac ttg aac tgt 2592 Ile Leu Ser Pro Gly Tyr Pro Glu Pro Tyr Gly Asn Asn Leu Asn Cys 850 855 860 ata tgg aag atc ata gtt acg gag ggc tcg gga att cag atc caa gtg 2640 Ile Trp Lys Ile Ile Val Thr Glu Gly Ser Gly Ile Gln Ile Gln Val 865 870 875 880 atc agt ttt gcc acg gag cag aac tgg gac tcc ctt gag atc cac gat 2688 Ile Ser Phe Ala Thr Glu Gln Asn Trp Asp Ser Leu Glu Ile His Asp 885 890 895 ggt ggg gat gtg acc gca ccc aga ctg gga agc ttc tca ggc acc aca 2736 Gly Gly Asp Val Thr Ala Pro Arg Leu Gly Ser Phe Ser Gly Thr Thr 900 905 910 gta ccg gca ctg ctg aac agt act tcc aac caa ctc tac ctg cat ttc 2784 Val Pro Ala Leu Leu Asn Ser Thr Ser Asn Gln Leu Tyr Leu His Phe 915 920 925 cag tct gac att agt gtg gca gct gct ggt ttc cac ctg gaa tac aaa 2832 Gln Ser Asp Ile Ser Val Ala Ala Ala Gly Phe His Leu Glu Tyr Lys 930 935 940 act gta ggt ctt gct gca tgc caa gaa cca gcc ctc ccc agc aac agc 2880 Thr Val Gly Leu Ala Ala Cys Gln Glu Pro Ala Leu Pro Ser Asn Ser 945 950 955 960 atc aaa atc gga gat cgg tac atg gtg aac gac gtg ctc tcc ttc cag 2928 Ile Lys Ile Gly Asp Arg Tyr Met Val Asn Asp Val Leu Ser Phe Gln 965 970 975 tgc gag ccc ggg tac acc ctg cag ggc cgt tcc cac att tcc tgt atg 2976 Cys Glu Pro Gly Tyr Thr Leu Gln Gly Arg Ser His Ile Ser Cys Met 980 985 990 cca ggg acc gtt cgc cgt tgg aac tat ccg tct ccc ctg tgc att gca 3024 Pro Gly Thr Val Arg Arg Trp Asn Tyr Pro Ser Pro Leu Cys Ile Ala 995 1000 1005 acc tgt gga ggg acg ctg agc acc ttg ggt ggt gtg atc ctg agc ccc 3072 Thr Cys Gly Gly Thr Leu Ser Thr Leu Gly Gly Val Ile Leu Ser Pro 1010 1015 1020 ggc ttc cca ggt tct tac ccc aac aac tta gac tgc acc tgg agg atc 3120 Gly Phe Pro Gly Ser Tyr Pro Asn Asn Leu Asp Cys Thr Trp Arg Ile 1025 1030 1035 1040 tca tta ccc atc ggc tat ggt aag tgaaaatgtt accaattcct aaaagttcat 3174 Ser Leu Pro Ile Gly Tyr Gly Lys 1045 ttttttcatt tccatcttgg aaagaattaa gcagaataaa atgccttatt ctgttggcat 3234 aactgtatct gtaattgaaa gtggcgtaca gatttaaata aagctttggc agagt 3289 <210> 23 <211> 3373 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(2341) <400> 23 a aaa gat gca agt atg acc caa gcc ctt tgc aga atg att gac tgg cta 49 Lys Asp Ala Ser Met Thr Gln Ala Leu Cys Arg Met Ile Asp Trp Leu 1 5 10 15 tcc tgg cca ttg gct cag cat gtg gat aca tgg gta att gca ctc ctg 97 Ser Trp Pro Leu Ala Gln His Val Asp Thr Trp Val Ile Ala Leu Leu 20 25 30 aaa gga ctg gca gct gtc cag aag ttt act att ttg ata gat gtt act 145 Lys Gly Leu Ala Ala Val Gln Lys Phe Thr Ile Leu Ile Asp Val Thr 35 40 45 ttg ctg aaa ata gaa ctg gtt ttt aat cga ctt tgg ttt cct ctt gtg 193 Leu Leu Lys Ile Glu Leu Val Phe Asn Arg Leu Trp Phe Pro Leu Val 50 55 60 aga cct ggt gct ctt gca gtt ctt tct cac atg ctg ctt agc ttt cag 241 Arg Pro Gly Ala Leu Ala Val Leu Ser His Met Leu Leu Ser Phe Gln 65 70 75 80 cat tct cca gag gcg ttc cat ttg att gtt cct cat gtg gtt aat ttg 289 His Ser Pro Glu Ala Phe His Leu Ile Val Pro His Val Val Asn Leu 85 90 95 gtt cat tct ttc aaa aat gat ggt ctg cct tca agt aca gcc ttc tta 337 Val His Ser Phe Lys Asn Asp Gly Leu Pro Ser Ser Thr Ala Phe Leu 100 105 110 gta caa tta aca gaa ttg ata cac tgt atg atg tat cat tat tct gga 385 Val Gln Leu Thr Glu Leu Ile His Cys Met Met Tyr His Tyr Ser Gly 115 120 125 ttt cca gat ctc tat gaa cct att ctg gag gca ata aag gat ttt cct 433 Phe Pro Asp Leu Tyr Glu Pro Ile Leu Glu Ala Ile Lys Asp Phe Pro 130 135 140 aag ccc agt gaa gag aag att aag tta att ctc aat caa agt gcc tgg 481 Lys Pro Ser Glu Glu Lys Ile Lys Leu Ile Leu Asn Gln Ser Ala Trp 145 150 155 160 act tct caa tcc aat tct ttg gcg tct tgc ttg tct aga ctt tct gga 529 Thr Ser Gln Ser Asn Ser Leu Ala Ser Cys Leu Ser Arg Leu Ser Gly 165 170 175 aaa tct gaa act ggg aaa act ggt ctt att aac cta gga aat aca tgt 577 Lys Ser Glu Thr Gly Lys Thr Gly Leu Ile Asn Leu Gly Asn Thr Cys 180 185 190 tat atg aac agt gtt ata caa gcc ttg ttt atg gcc aca gat ttc agg 625 Tyr Met Asn Ser Val Ile Gln Ala Leu Phe Met Ala Thr Asp Phe Arg 195 200 205 aga caa gta tta tct tta aat cta aat ggg tgc aat tca tta atg aaa 673 Arg Gln Val Leu Ser Leu Asn Leu Asn Gly Cys Asn Ser Leu Met Lys 210 215 220 aaa tta cag cat ctt ttt gcc ttt ctg gcc cat aca cag agg gaa gca 721 Lys Leu Gln His Leu Phe Ala Phe Leu Ala His Thr Gln Arg Glu Ala 225 230 235 240 tac gca cct cgg ata ttc ttt gag gct tcc aga cct cca tgg ttt act 769 Tyr Ala Pro Arg Ile Phe Phe Glu Ala Ser Arg Pro Pro Trp Phe Thr 245 250 255 ccc aga tca cag caa gac tgt tct gaa tac ctc aga ttt ctc ctt gac 817 Pro Arg Ser Gln Gln Asp Cys Ser Glu Tyr Leu Arg Phe Leu Leu Asp 260 265 270 agg ctc cat gaa gaa gaa aag atc ttg aaa gtt cag gcc tca cac aag 865 Arg Leu His Glu Glu Glu Lys Ile Leu Lys Val Gln Ala Ser His Lys 275 280 285 cct tct gaa att ctg gaa tgc agt gaa act tct tta cag gaa gta gct 913 Pro Ser Glu Ile Leu Glu Cys Ser Glu Thr Ser Leu Gln Glu Val Ala 290 295 300 agt aaa gca gca gta cta aca gag acc cct cgt aca agt gac ggt gag 961 Ser Lys Ala Ala Val Leu Thr Glu Thr Pro Arg Thr Ser Asp Gly Glu 305 310 315 320 aag act tta ata gaa aaa atg ttt gga gga aaa cta cga act cac ata 1009 Lys Thr Leu Ile Glu Lys Met Phe Gly Gly Lys Leu Arg Thr His Ile 325 330 335 cgt tgt ttg aac tgc agg agt acc tca caa aaa gtg gaa gcc ttt aca 1057 Arg Cys Leu Asn Cys Arg Ser Thr Ser Gln Lys Val Glu Ala Phe Thr 340 345 350 gat ctt tcg ctt gcc ttt tgt cct tcc tct tct ttg gaa aac atg tct 1105 Asp Leu Ser Leu Ala Phe Cys Pro Ser Ser Ser Leu Glu Asn Met Ser 355 360 365 gtc caa gat cca gca tca tca ccc agt ata caa gat ggt ggt cta atg 1153 Val Gln Asp Pro Ala Ser Ser Pro Ser Ile Gln Asp Gly Gly Leu Met 370 375 380 caa gcc tct gta ccc ggt cct tca gaa gaa cca gta gtt tat aat cca 1201 Gln Ala Ser Val Pro Gly Pro Ser Glu Glu Pro Val Val Tyr Asn Pro 385 390 395 400 aca aca gct gcc ttc atc tgt gac tca ctt gtg aat gaa aaa acc ata 1249 Thr Thr Ala Ala Phe Ile Cys Asp Ser Leu Val Asn Glu Lys Thr Ile 405 410 415 ggc agt cct cct aat gag ttt tac tgt tct gaa aac act tct gtc cct 1297 Gly Ser Pro Pro Asn Glu Phe Tyr Cys Ser Glu Asn Thr Ser Val Pro 420 425 430 aac gaa tct aac aag att ctt gtt aat aaa gat gta cct cag aaa cca 1345 Asn Glu Ser Asn Lys Ile Leu Val Asn Lys Asp Val Pro Gln Lys Pro 435 440 445 gga ggt gaa acc aca cct tca gta act gac tta cta aat tat ttt ttg 1393 Gly Gly Glu Thr Thr Pro Ser Val Thr Asp Leu Leu Asn Tyr Phe Leu 450 455 460 gct cca gag att ctt act ggt gat aac caa tat tat tgt gaa aac tgt 1441 Ala Pro Glu Ile Leu Thr Gly Asp Asn Gln Tyr Tyr Cys Glu Asn Cys 465 470 475 480 gcc tct ctg caa aat gct gag aaa act atg caa atc acg gag gaa cct 1489 Ala Ser Leu Gln Asn Ala Glu Lys Thr Met Gln Ile Thr Glu Glu Pro 485 490 495 gaa tac ctt att ctt act ctc ctg aga ttt tca tat gat cag aag tat 1537 Glu Tyr Leu Ile Leu Thr Leu Leu Arg Phe Ser Tyr Asp Gln Lys Tyr 500 505 510 cat gtg aga agg aaa att tta gac aat gta tca ctg cca ctg gtt ttg 1585 His Val Arg Arg Lys Ile Leu Asp Asn Val Ser Leu Pro Leu Val Leu 515 520 525 gag ttg cca gtt aaa aga att act tct ttc tct tca ttg tca gaa agt 1633 Glu Leu Pro Val Lys Arg Ile Thr Ser Phe Ser Ser Leu Ser Glu Ser 530 535 540 tgg tct gta gat gtt gac ttc act gat ctt agt gag aac ctt gct aaa 1681 Trp Ser Val Asp Val Asp Phe Thr Asp Leu Ser Glu Asn Leu Ala Lys 545 550 555 560 aaa tta aag cct tca ggg act gat gaa gct tcc tgc aca aaa ttg gtg 1729 Lys Leu Lys Pro Ser Gly Thr Asp Glu Ala Ser Cys Thr Lys Leu Val 565 570 575 ccc tat cta tta agt tcc gtt gtg gtt cac tct ggt ata tcc tct gaa 1777 Pro Tyr Leu Leu Ser Ser Val Val Val His Ser Gly Ile Ser Ser Glu 580 585 590 agt ggg cat tac tat tct tat gcc aga aat atc aca agt aca gac tct 1825 Ser Gly His Tyr Tyr Ser Tyr Ala Arg Asn Ile Thr Ser Thr Asp Ser 595 600 605 tca tat cag atg tac cac cag tct gag gct ctg gca tta gca tcc tcc 1873 Ser Tyr Gln Met Tyr His Gln Ser Glu Ala Leu Ala Leu Ala Ser Ser 610 615 620 cag agt cat tta cta ggg aga gat agt ccc agt gca gtt ttt gaa cag 1921 Gln Ser His Leu Leu Gly Arg Asp Ser Pro Ser Ala Val Phe Glu Gln 625 630 635 640 gat ttg gaa aat aag gaa atg tca aaa gaa tgg ttt tta ttt aat gac 1969 Asp Leu Glu Asn Lys Glu Met Ser Lys Glu Trp Phe Leu Phe Asn Asp 645 650 655 agt aga gtg aca ttt act tca ttt cag tca gtc cag aaa att acg agc 2017 Ser Arg Val Thr Phe Thr Ser Phe Gln Ser Val Gln Lys Ile Thr Ser 660 665 670 agg ttt cca aag gac aca gct tat gtg ctt ttg tat aaa aaa cag cat 2065 Arg Phe Pro Lys Asp Thr Ala Tyr Val Leu Leu Tyr Lys Lys Gln His 675 680 685 agt act aat ggt tta agt ggt aat aac cca acc agt gga ctc tgg ata 2113 Ser Thr Asn Gly Leu Ser Gly Asn Asn Pro Thr Ser Gly Leu Trp Ile 690 695 700 aat gga gac cca cct cta cag aaa gaa ctt atg gat gct ata aca aaa 2161 Asn Gly Asp Pro Pro Leu Gln Lys Glu Leu Met Asp Ala Ile Thr Lys 705 710 715 720 gac aat aaa cta tat tta cag gaa caa gag ttg aat gct cga gcc cgg 2209 Asp Asn Lys Leu Tyr Leu Gln Glu Gln Glu Leu Asn Ala Arg Ala Arg 725 730 735 gcc ctc caa gct gca tct gct tca tgt tca ttt cgg ccc aat gga ttt 2257 Ala Leu Gln Ala Ala Ser Ala Ser Cys Ser Phe Arg Pro Asn Gly Phe 740 745 750 gat gac aac gac cca cca gga agc tgt gga cca act ggt gga ggg ggt 2305 Asp Asp Asn Asp Pro Pro Gly Ser Cys Gly Pro Thr Gly Gly Gly Gly 755 760 765 gga gga gga ttt aat aca gtt ggc aga ctc gta ttt tgatcctgag 2351 Gly Gly Gly Phe Asn Thr Val Gly Arg Leu Val Phe 770 775 780 agagtccaaa atgcactggt cacgaaacgt ctaatactat gactgttaaa atgtcagact 2411 ataacaaata tctatctttt atttttcatt agacccttat acttcaagag aacacactca 2471 gtgcttgttt ttattttctt gacacattta ttaacaaaat gcatcatgga aaaaaaatct 2531 acctcttaaa attccatttg cttttatggt tagacatgct tgaccaaaaa tgttcagaag 2591 aaaatatgta cctggtccct aattaagctg cgttaaattt ggtagaagca tttaaatggt 2651 ctatcttcag ttttactgaa caaaaaatgt aatttattta gcattcttta taaaagaatt 2711 gatgctagag gtaaaaaaaa atacttgttt ttaaaaaatc ctttacgtct tgtgtaatta 2771 ccccattatt aaattcaagt ccttgaaaat caactagaga ttataaagtc tctaaagaag 2831 gcaataacaa aatttatcaa gatatagtac ttttcagttt ttgtttagtg tcttcagcat 2891 cactgtgtct gtatttcaag tacaaatgtt tttaaaaagg attctttata catatgtgct 2951 gaattgattt taagaaagtt gcatgatcct gtaggagcaa catttttacc taaaaaatgc 3011 taactttata gtatttctaa ttgttcaagg attttaaaat tctatttcag ggagtatatc 3071 ttctgtggtt ttgaaggagg tgagttctgt atgtgccttg cagtactgta attcaaaaat 3131 aggaatcttt ggctgcaaaa ttttaatgaa atgttaggaa gtaattttcg tgctaacatt 3191 aaaattataa ctttttgaaa ggtaatagat tttccagaag taaaatctga tggttctaaa 3251 tcaatcaatg tgatagttca tttttaactc ttagaagaat tcagaggaaa ttaacccagc 3311 taagtaaaaa atctgtcttg attttgttac ttattcctca gaatattaaa cattgatcac 3371 at 3373 <210> 24 <211> 3439 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1032) <400> 24 gga gaa gct agg aag aaa atg gcg gcc gtg gct gca gag gcg gca gcg 48 Gly Glu Ala Arg Lys Lys Met Ala Ala Val Ala Ala Glu Ala Ala Ala 1 5 10 15 act gca gcg tcc ccc ggg gag ggg ggc gcc ggc gag gcc gag ccg gag 96 Thr Ala Ala Ser Pro Gly Glu Gly Gly Ala Gly Glu Ala Glu Pro Glu 20 25 30 atg gag ccc atc ccc ggc agt gag gcc ggc act gac ccc ctc ccg gtc 144 Met Glu Pro Ile Pro Gly Ser Glu Ala Gly Thr Asp Pro Leu Pro Val 35 40 45 acg gcc act gaa gcg tct gtg ccg gat ggc gag act gac ggg cag caa 192 Thr Ala Thr Glu Ala Ser Val Pro Asp Gly Glu Thr Asp Gly Gln Gln 50 55 60 tcc gct cct cag gcc gac gag ccg ccg ctc ccg ccg cca ccg ccg ccg 240 Ser Ala Pro Gln Ala Asp Glu Pro Pro Leu Pro Pro Pro Pro Pro Pro 65 70 75 80 ccg ggg gag ctc gcc cgc agc cca gag gcg gtg ggg ccg gag ctg gag 288 Pro Gly Glu Leu Ala Arg Ser Pro Glu Ala Val Gly Pro Glu Leu Glu 85 90 95 gct gag gag aaa ctg tcc gtt cgg gtg gcg gag tcg gcg gca gcc gcg 336 Ala Glu Glu Lys Leu Ser Val Arg Val Ala Glu Ser Ala Ala Ala Ala 100 105 110 cct cag gga ggg ccg gaa ctt cca cct tct cct gca tcg ccg ccg gag 384 Pro Gln Gly Gly Pro Glu Leu Pro Pro Ser Pro Ala Ser Pro Pro Glu 115 120 125 cag ccc ccg gct ccc gag gag cgc gag gag ccg ccg ctg cct cag ccc 432 Gln Pro Pro Ala Pro Glu Glu Arg Glu Glu Pro Pro Leu Pro Gln Pro 130 135 140 gta gcc ccg gcg ctc gtg ccg ccg gcg ggc ggg gac tcc acg gtg tcg 480 Val Ala Pro Ala Leu Val Pro Pro Ala Gly Gly Asp Ser Thr Val Ser 145 150 155 160 caa ctg atc ccg ggc tcg gag gtg cgg gtc acg ctg gac cac atc att 528 Gln Leu Ile Pro Gly Ser Glu Val Arg Val Thr Leu Asp His Ile Ile 165 170 175 gag gac gcg ctt gtc gtg tcg ttc cgc ttc ggg gag aag ctc ttc tcc 576 Glu Asp Ala Leu Val Val Ser Phe Arg Phe Gly Glu Lys Leu Phe Ser 180 185 190 ggg gtc ctc atg gat ctg tcc aaa agg tac cgc gcc cgc ccc cag cac 624 Gly Val Leu Met Asp Leu Ser Lys Arg Tyr Arg Ala Arg Pro Gln His 195 200 205 cct ccg gtc cgc tgg gtc ccc agg gag gga gtg agc ccg ggc ggc ccc 672 Pro Pro Val Arg Trp Val Pro Arg Glu Gly Val Ser Pro Gly Gly Pro 210 215 220 ctc tcc ccg agc cct cgc ttc ccc gct gcc cgg ggc ccc gcc ctc tgg 720 Leu Ser Pro Ser Pro Arg Phe Pro Ala Ala Arg Gly Pro Ala Leu Trp 225 230 235 240 tcc tgc gcg gcg cgt ggc gcg cgc tcc gag tgg ggc agg cgc gcg aga 768 Ser Cys Ala Ala Arg Gly Ala Arg Ser Glu Trp Gly Arg Arg Ala Arg 245 250 255 ccg gga gag ggc ggt ccc ggc ccc agg tgg gcg cct gcg ggg cag gtg 816 Pro Gly Glu Gly Gly Pro Gly Pro Arg Trp Ala Pro Ala Gly Gln Val 260 265 270 tgc cac cag gtg gga ggg tgc agg tgc aga tgg gct cac agg tct cac 864 Cys His Gln Val Gly Gly Cys Arg Cys Arg Trp Ala His Arg Ser His 275 280 285 ccc tca cgc ctg gtc ttc ttc tgc gac ttg gcc tgg agt cac cgt cac 912 Pro Ser Arg Leu Val Phe Phe Cys Asp Leu Ala Trp Ser His Arg His 290 295 300 tgg gcg ggt ggg tta atg caa gat gca gat gga ttt ttg cag aga acg 960 Trp Ala Gly Gly Leu Met Gln Asp Ala Asp Gly Phe Leu Gln Arg Thr 305 310 315 320 gag tgt tgg acg ggg gga cgg ggg ggc ggg ggg cat tgc ttg cga gga 1008 Glu Cys Trp Thr Gly Gly Arg Gly Gly Gly Gly His Cys Leu Arg Gly 325 330 335 ggc act tgt ctg tcc tct aac gtt taactttagc gggattggag aaaggggtgt 1062 Gly Thr Cys Leu Ser Ser Asn Val 340 gtacattggg gttcccaaaa ggttacctgt cactccttac agggggaaga gcatttgtta 1122 aaatgaacct tttaactgta attcttacgg ttagaagtca ttcccgttag gttaaccatt 1182 caacagagaa gcatattttg ctaattttaa tgatagttta agaaaagttt aaagaagaga 1242 ttggagattt ttaaaaaatc ctttaatgtc aaggtggtgt agcataaaaa tgttcaagta 1302 acttctaaca cctgggattc agtttatgta ttaaggacaa gaaggttgag ttcatctaca 1362 aatttggctt aaccacattt tcattttttg atttaaaatg tttttgggct ctgctttcaa 1422 caggggaaga gaacctgttc taagtctgga gttaaccttt ttattctctt cttttgcaga 1482 tatgaagtgc agagactccc attcacggct ttccattctg tttcctgcaa cagcacacgc 1542 tctgatcgta tctcacctgt ttgcaatggc ttattagtat gttttactct taaacttgct 1602 tgctctccca tcaagaccca ggaatccttc tttcccattt ggggaaaaaa gccatttaaa 1662 atttcatatt gaagtatggt gtttgagggg aaagatgaga gcagttattc tgtattattt 1722 aatctcaaat atcttttttt ttttttttga gacggagtct cactctgtca cccaggctgg 1782 agtgcagtgg cgccatatcg tctcactgca acctccgcct cctgggttca agcgattctc 1842 ccgcctcagc ctcccaagta gctgggacta caggcgtgcg ccaccatgct ggtctaattt 1902 ttgtattttt taactagagc cgggatttca ccatgttggc caggctggtc ttgaaatcct 1962 gacctcaggt tatccacccg cctcagcctc ccaaagggct gggattacag gcatgagccg 2022 ccgtgcccgg cctcaagtat cttttttaaa aataattttg gattagggca tttgcacttc 2082 tgtttatgtt tgtttgttta cttatttatt agagacaggg tcttgctgtg ctgcctaggc 2142 tggtctcaga ctcctgggct caagcgatcc tactgccttg gccttccaaa gtgctgaaat 2202 tacaggcgtg agccactgtg cccggcctgc actcctgttt tcataattag aaagcagaat 2262 aaggtgagtg tgctttctat tgatgtattt tatttattta tttatttatt tatttttgag 2322 acagagtttc gctcttgttg tccaggctgc agtggtacaa tctctgctca ctgcaccctc 2382 cacctccctg gttcaagtga ttctcctacc tcagcctccc aagtagctgg gattacaggc 2442 atgtgccacc acgcctggct aattttgtat ttttagtaga gatggggttt caccatgttg 2502 gtcaggttgg tctcaaactc ctgacctcag gtgatccacc caccttggcc tcccaaagtg 2562 ctgagattac aggcatgagc cacctcgccc ggcctctact gatgtatata atagtaagag 2622 acactctggt gtgtatgctg ttgaatgaaa cagaagagat ggccagtgat tgtgtgagaa 2682 tctggatttc aaatctgcaa aaggaaggtg cagaaggttt gggccccatg gtatccctgt 2742 gacagtattt cccaaaaggg aatataagga taaaccagaa gccatgccgc tccaaagtaa 2802 tacattccaa gaagggacag aagtcaagtg tgaagcaaat ggtgctgttc ccgatgaccc 2862 ttctcctgtc ccgcatcccg agctgagctt ggctgaaagc ctgtggactt ccaaaccacc 2922 acctctcttc catgaaggag caccttatcc tccccctttg tttatcaggg acacatataa 2982 ccaatcaata cctcagccac ctcctcggaa aattaagcga cccaaacgaa aaatgtacag 3042 ggaagaaccc acttcaataa tgaatgctat taaactacga cccaggcaag ttctgtgtga 3102 taaatgtaaa aacagtgttg ttgctgaaaa aaaggaaatt agaaaaggta gtagtgcaac 3162 tgactcttct aaatatgaag ataaaaaacg gagaaatgaa agtgtaacta ctgtgaacaa 3222 aaaactgaaa actgaccata aagtggatgg gaaaaaccaa aatgaaagcc agaaaagaaa 3282 tgctgtggtt aaggtttcaa atattgctca cagcagaggc agagtagtaa aagtttctgc 3342 tcaggcaaat acatcaaaag ctcagttaag tactaaaaaa gttctccaga gtaagaacat 3402 ggatcatgcg aaagctcggg aagtgttaaa aattgcc 3439 <210> 25 <211> 3083 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (777)..(2366) <400> 25 cgctcagccc gggcgggcga tgcgggcggc gcgggcggcc ccctcccccg gcccgcgtct 60 ccgggacggc tgcgggcggc ccccccggcg gccggagggc tccctggccc cgatctgacg 120 gcggcggcgg cggcggccac agcggcggga gcggcgcggg gaaggagcag cggctcgcag 180 ccctcggccc gcgcccccac ccagcgccag cccgaggggg gaggcgcagc gccggagggt 240 ggcggtcctc ggccctccca ggtctccgcg ccgggaagcc gctccgagcc ggggctggag 300 ggttgttttg ccgttgtgtt gagcacgtca cccattaaga gccctttaaa gacctggatt 360 gattggaagg acaaaaatta aaagcaatct gatccagcct catgcaggat ccctgcggat 420 tttctcctta tcccatttcc atccactgtc acaatttgag aatctgcctg atttgatcag 480 attcacctcc aggggaggtg tgataccagg gttaggagga cgtgaagtta tgggcaactt 540 tctgatctgt ccatcagcag tctgagaaac gctggctctg aattttccgt gtcggccttt 600 tggaaacaac aagttcctcg ctgtttgcaa agcttcagtg ctcgggtccc tgggacaccc 660 cggccaccct cgcctggtag atgtggcatt tccatgctga ggccgcgagt cccgcctgac 720 cccgtcgctg cctctccagg gcttctctgg gccgcgcctc tgcagactgc gcagcc atg 779 Met 1 ctg cat ctg ctg gcg ctc ttc ctg cac tgc ctc cct ctg gcc tct ggg 827 Leu His Leu Leu Ala Leu Phe Leu His Cys Leu Pro Leu Ala Ser Gly 5 10 15 gac tat gac atc tgc aaa tcc tgg gtg acc aca gat gag ggc ccc acc 875 Asp Tyr Asp Ile Cys Lys Ser Trp Val Thr Thr Asp Glu Gly Pro Thr 20 25 30 tgg gag ttc tac gcc tgc cag ccc aag gtg atg cgc ctg aag gac tac 923 Trp Glu Phe Tyr Ala Cys Gln Pro Lys Val Met Arg Leu Lys Asp Tyr 35 40 45 gtc aag gtg aag gtg gag ccc tca ggc atc aca tgt gga gac ccc cct 971 Val Lys Val Lys Val Glu Pro Ser Gly Ile Thr Cys Gly Asp Pro Pro 50 55 60 65 gag agg ttc tgc tcc cat gag aat ccc tac cta tgc agc aac gag tgt 1019 Glu Arg Phe Cys Ser His Glu Asn Pro Tyr Leu Cys Ser Asn Glu Cys 70 75 80 gac gcc tcc aac ccg gac ctg gcc cac ccg ccc agg ctc atg ttc gac 1067 Asp Ala Ser Asn Pro Asp Leu Ala His Pro Pro Arg Leu Met Phe Asp 85 90 95 aag gag gag gag ggc ctg gcc acc tac tgg cag agc atc acc tgg agc 1115 Lys Glu Glu Glu Gly Leu Ala Thr Tyr Trp Gln Ser Ile Thr Trp Ser 100 105 110 cgc tac ccc agc ccg ctg gaa gcc aac atc acc ctt tcg tgg aac aag 1163 Arg Tyr Pro Ser Pro Leu Glu Ala Asn Ile Thr Leu Ser Trp Asn Lys 115 120 125 acc gtg gag ctg acc gac gac gtg gtg atg acc ttc gag tac ggc cgg 1211 Thr Val Glu Leu Thr Asp Asp Val Val Met Thr Phe Glu Tyr Gly Arg 130 135 140 145 ccc acg gtc atg gtc ctg gag aag tcc ctg gac aac ggg cgc acc tgg 1259 Pro Thr Val Met Val Leu Glu Lys Ser Leu Asp Asn Gly Arg Thr Trp 150 155 160 cag ccc tac cag ttc tac gcc gag gac tgc atg gag gcc ttc ggt atg 1307 Gln Pro Tyr Gln Phe Tyr Ala Glu Asp Cys Met Glu Ala Phe Gly Met 165 170 175 tcc gcc cgc cgg gcc cgc gac atg tca tcc tcc agc gcg cac cgc gtg 1355 Ser Ala Arg Arg Ala Arg Asp Met Ser Ser Ser Ser Ala His Arg Val 180 185 190 ctc tgc acc gag gag tac tcg cgc tgg gca ggc tcc aag aag gag aag 1403 Leu Cys Thr Glu Glu Tyr Ser Arg Trp Ala Gly Ser Lys Lys Glu Lys 195 200 205 cac gtg cgc ttc gag gtg cgg gac cgc ttc gcc atc ttt gcc ggc ccc 1451 His Val Arg Phe Glu Val Arg Asp Arg Phe Ala Ile Phe Ala Gly Pro 210 215 220 225 gac ctg cgc aac atg gac aac ctc tac acg cgg ctg gag agc gcc aag 1499 Asp Leu Arg Asn Met Asp Asn Leu Tyr Thr Arg Leu Glu Ser Ala Lys 230 235 240 ggc ctc aag gag ttc ttc acc ctc acc gac ctg cgc atg cgg ctg ctg 1547 Gly Leu Lys Glu Phe Phe Thr Leu Thr Asp Leu Arg Met Arg Leu Leu 245 250 255 cgc ccg gcg ctg ggc ggc acc tat gtg cag cgg gag aac ctc tac aag 1595 Arg Pro Ala Leu Gly Gly Thr Tyr Val Gln Arg Glu Asn Leu Tyr Lys 260 265 270 tac ttc tac gcc atc tcc aac atc gag gtc atc ggc agg tgc aag tgc 1643 Tyr Phe Tyr Ala Ile Ser Asn Ile Glu Val Ile Gly Arg Cys Lys Cys 275 280 285 aac ctg cat gcc aac ctg tgc tcc atg cgc gag ggc agc ctg cag tgc 1691 Asn Leu His Ala Asn Leu Cys Ser Met Arg Glu Gly Ser Leu Gln Cys 290 295 300 305 gag tgc gag cac aac acc acc ggc ccc gac tgc ggc aag tgc aag aag 1739 Glu Cys Glu His Asn Thr Thr Gly Pro Asp Cys Gly Lys Cys Lys Lys 310 315 320 aat ttc cgc acc cgg tcc tgg cgg gcc ggc tcc tac ctg ccg ctg ccc 1787 Asn Phe Arg Thr Arg Ser Trp Arg Ala Gly Ser Tyr Leu Pro Leu Pro 325 330 335 cat ggc tct ccc aac gcc tgt gcc gct gca ggt tcc ttt ggc aac tgc 1835 His Gly Ser Pro Asn Ala Cys Ala Ala Ala Gly Ser Phe Gly Asn Cys 340 345 350 gaa tgc tac ggt cac tcc aac cgc tgc agc tac att gac ttc ctg aat 1883 Glu Cys Tyr Gly His Ser Asn Arg Cys Ser Tyr Ile Asp Phe Leu Asn 355 360 365 gtg gtg acc tgc gtc agc tgc aag cac aac acg cga ggt cag cac tgc 1931 Val Val Thr Cys Val Ser Cys Lys His Asn Thr Arg Gly Gln His Cys 370 375 380 385 cag cac tgc cgg ctg ggc tac tac cgc aac ggc tcg gca gag ctg gat 1979 Gln His Cys Arg Leu Gly Tyr Tyr Arg Asn Gly Ser Ala Glu Leu Asp 390 395 400 gat gag aac gtc tgc att gag tgt aac tgc aac cag ata ggc tcc gtg 2027 Asp Glu Asn Val Cys Ile Glu Cys Asn Cys Asn Gln Ile Gly Ser Val 405 410 415 cac gac cgg tgc aac gag acc ggc ttc tgc gag tgc cgc gag ggc gcg 2075 His Asp Arg Cys Asn Glu Thr Gly Phe Cys Glu Cys Arg Glu Gly Ala 420 425 430 gcg ggc ccc aag tgc gac gac tgc ctc ccc acg cac tac tgg cgc cag 2123 Ala Gly Pro Lys Cys Asp Asp Cys Leu Pro Thr His Tyr Trp Arg Gln 435 440 445 ggc tgc tac ccc aac gtg tgc gac gac gac cag ctg ctg tgc cag aac 2171 Gly Cys Tyr Pro Asn Val Cys Asp Asp Asp Gln Leu Leu Cys Gln Asn 450 455 460 465 gga ggc acc tgc ctg cag aac cag cgc tgc gcc tgc ccg cgc ggc tac 2219 Gly Gly Thr Cys Leu Gln Asn Gln Arg Cys Ala Cys Pro Arg Gly Tyr 470 475 480 acc ggc gtg cgc tgc gag cag ccc cgc tgc gac ccc gcc gac gat gac 2267 Thr Gly Val Arg Cys Glu Gln Pro Arg Cys Asp Pro Ala Asp Asp Asp 485 490 495 ggc ggt ctg gac tgc gac cgc gcg ccc ggg gcc gcc ccg cgc ccc gcc 2315 Gly Gly Leu Asp Cys Asp Arg Ala Pro Gly Ala Ala Pro Arg Pro Ala 500 505 510 acc ctg ctc ggc tgc ctg ctg ctg ctg ggg ctg gcc gcc cgc ctg ggc 2363 Thr Leu Leu Gly Cys Leu Leu Leu Leu Gly Leu Ala Ala Arg Leu Gly 515 520 525 cgc tgagccccgc ccggaggacg ctccccgcac ccggaggccg ggggtcccgg 2416 Arg 530 ggtcccgggg cggggccggc gtccgaggcc gggcggtgag aagggtgcgg cccgaggtgc 2476 tcccaggtgc tactcagcag ggccccccgc ccggcccgcg ctcccgcccg cactgccctc 2536 cccccgcagc aggggcgcct tgggactccg gtccccgcgc ctgcgatttg gtttcgtttt 2596 tcttttgtat tatccgccgc ccagttcctt tttttgtctt tctctctctc tctttttttt 2656 tttttttttc tggcggtgag ccagagggtc gggagaaacg ctgctcgccc cacaccccgt 2716 cctgcctccc accacactta cacacacggg actgtggccg acaccccctg gcctgtgcca 2776 ggctcacggg cggcggcgga ccccgacctc cagttgccta caattccagt cgctgacttg 2836 gtcctgtttt ctattcttta tttttcctgc aacccaccag accccaggcc tcaccggagg 2896 cccggtgacc acggaactca ccgtctgggg gaggaggaga gaaggaaggg gtggggggcc 2956 tggaaacttc gttctgtaga gaactatttt tgtttgtatt cactgtcccc tgcaaggggg 3016 acggggcggg agcactggtc accgcggggg ccgatggtgg agaatccgag gagtaaagag 3076 tttgctc 3083 <210> 26 <211> 3016 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(1674) <400> 26 aag atg caa gaa aag gac agt ctc aca gaa agc ttc cca gca gct ctg 48 Lys Met Gln Glu Lys Asp Ser Leu Thr Glu Ser Phe Pro Ala Ala Leu 1 5 10 15 gcc aaa acc ctt gag gat gca gcg ctg agg gag gag aat gaa caa ctt 96 Ala Lys Thr Leu Glu Asp Ala Ala Leu Arg Glu Glu Asn Glu Gln Leu 20 25 30 tcc aat gcc tca tca tcc atc ggc tta tgc gta gat cct tta aaa ggt 144 Ser Asn Ala Ser Ser Ser Ile Gly Leu Cys Val Asp Pro Leu Lys Gly 35 40 45 cgc tgt ctc gtt gcc aca aaa gat att ctc cca gga gag ctc ctg gtg 192 Arg Cys Leu Val Ala Thr Lys Asp Ile Leu Pro Gly Glu Leu Leu Val 50 55 60 cag gag gat gct ttt gtg agt gtt ctc aac cca gga gaa ctg cca cca 240 Gln Glu Asp Ala Phe Val Ser Val Leu Asn Pro Gly Glu Leu Pro Pro 65 70 75 80 ccg cat cac ggc cta gac agc aaa tgg gac acc aga gtc acc aat ggg 288 Pro His His Gly Leu Asp Ser Lys Trp Asp Thr Arg Val Thr Asn Gly 85 90 95 gac ctc tat tgt cac cga tgt ttg aag cac act ttg gcc aca gtt ccg 336 Asp Leu Tyr Cys His Arg Cys Leu Lys His Thr Leu Ala Thr Val Pro 100 105 110 tgt gac gga tgc agt tat gcc aag tat tgc agc cag gag tgt ttg cag 384 Cys Asp Gly Cys Ser Tyr Ala Lys Tyr Cys Ser Gln Glu Cys Leu Gln 115 120 125 cag gcc tgg gag ctc tac cac agg aca gaa tgt cct ctg gga ggg ctg 432 Gln Ala Trp Glu Leu Tyr His Arg Thr Glu Cys Pro Leu Gly Gly Leu 130 135 140 ctt ctc aca ctg ggt gtc ttt tgc cac att gcc ctg agg ttg act ctt 480 Leu Leu Thr Leu Gly Val Phe Cys His Ile Ala Leu Arg Leu Thr Leu 145 150 155 160 ttg gtg gga ttt gag gat gtt cgc aaa atc ata acg aag ctt tgt gat 528 Leu Val Gly Phe Glu Asp Val Arg Lys Ile Ile Thr Lys Leu Cys Asp 165 170 175 aag att agt aac aag gac atc tgt tta cct gaa agc aac aat cag gtc 576 Lys Ile Ser Asn Lys Asp Ile Cys Leu Pro Glu Ser Asn Asn Gln Val 180 185 190 aag aca ctt aat tat ggc cta ggg gag agt gag aaa aat ggc aac atc 624 Lys Thr Leu Asn Tyr Gly Leu Gly Glu Ser Glu Lys Asn Gly Asn Ile 195 200 205 gtt gag acc cca att cct gga tgc gat att aat ggg aag tat gaa aat 672 Val Glu Thr Pro Ile Pro Gly Cys Asp Ile Asn Gly Lys Tyr Glu Asn 210 215 220 aat tat aat gct gtc ttc aac ctt ttg ccc cac act gaa aac cat agc 720 Asn Tyr Asn Ala Val Phe Asn Leu Leu Pro His Thr Glu Asn His Ser 225 230 235 240 cca gag cac aaa ttc ctc tgt gct ctc tgt gtt tct gca ctg tgc aga 768 Pro Glu His Lys Phe Leu Cys Ala Leu Cys Val Ser Ala Leu Cys Arg 245 250 255 cag cta gaa gca gcc agt tta cag gcc atc cca act gag agg att gtg 816 Gln Leu Glu Ala Ala Ser Leu Gln Ala Ile Pro Thr Glu Arg Ile Val 260 265 270 aac tcc tct cag ctt aaa gca gca gtg aca cct gaa ttg tgt cct gac 864 Asn Ser Ser Gln Leu Lys Ala Ala Val Thr Pro Glu Leu Cys Pro Asp 275 280 285 gtg act att tgg gga gtg gcg atg ctg aga cac atg tta cag ctt cag 912 Val Thr Ile Trp Gly Val Ala Met Leu Arg His Met Leu Gln Leu Gln 290 295 300 tgt aac gct cag gcg atg acc acc ata caa cgc aca gga cct aaa ggg 960 Cys Asn Ala Gln Ala Met Thr Thr Ile Gln Arg Thr Gly Pro Lys Gly 305 310 315 320 agc atc gtt acc gac agc agg cag gtg cgc ctt gcc aca ggc atc ttc 1008 Ser Ile Val Thr Asp Ser Arg Gln Val Arg Leu Ala Thr Gly Ile Phe 325 330 335 cct gtt atc agc ctc ctg aac cac tcc tgt agc ccc aac acc agc gtg 1056 Pro Val Ile Ser Leu Leu Asn His Ser Cys Ser Pro Asn Thr Ser Val 340 345 350 tcc ttc att agc act gtc gcc acc atc cgg gcg tca cag tgg att aga 1104 Ser Phe Ile Ser Thr Val Ala Thr Ile Arg Ala Ser Gln Trp Ile Arg 355 360 365 aag ggg caa gag att ctc cac tgc tat ggg cct cac aag agc cgg atg 1152 Lys Gly Gln Glu Ile Leu His Cys Tyr Gly Pro His Lys Ser Arg Met 370 375 380 ggg gtt gcc gaa agg cag cag aag ctg agg tct cag tat ttc ttt gac 1200 Gly Val Ala Glu Arg Gln Gln Lys Leu Arg Ser Gln Tyr Phe Phe Asp 385 390 395 400 tgc gcc tgt cca gct tgt caa act gag gca cac agg atg gct gca ggg 1248 Cys Ala Cys Pro Ala Cys Gln Thr Glu Ala His Arg Met Ala Ala Gly 405 410 415 ccc agg tgg gaa gca ttc tgt tgc aac agt tgc gga gcg ccc atg cag 1296 Pro Arg Trp Glu Ala Phe Cys Cys Asn Ser Cys Gly Ala Pro Met Gln 420 425 430 gga gat gac gtg ctg cgc tgt ggc agc aga tct tgt gca gaa tcc gcc 1344 Gly Asp Asp Val Leu Arg Cys Gly Ser Arg Ser Cys Ala Glu Ser Ala 435 440 445 gtc agc agg gac cac ctg gtc tct cgg tta cag gac cta cag cag cag 1392 Val Ser Arg Asp His Leu Val Ser Arg Leu Gln Asp Leu Gln Gln Gln 450 455 460 gtc aga gtg gcc cag aag ctt ctc aga gat ggt gaa cta gag cga gct 1440 Val Arg Val Ala Gln Lys Leu Leu Arg Asp Gly Glu Leu Glu Arg Ala 465 470 475 480 gtt cag cgg ctg tcg ggg tgc cag cgt gac gcc gag agc ttc ctg tgg 1488 Val Gln Arg Leu Ser Gly Cys Gln Arg Asp Ala Glu Ser Phe Leu Trp 485 490 495 gca gag cac gcc gtg gtg gga gag atc gcg gat ggc ctg gcc cgg gcc 1536 Ala Glu His Ala Val Val Gly Glu Ile Ala Asp Gly Leu Ala Arg Ala 500 505 510 tgt gct gcc tta gga gac tgg caa aag tca gcc acc cat cta cag agg 1584 Cys Ala Ala Leu Gly Asp Trp Gln Lys Ser Ala Thr His Leu Gln Arg 515 520 525 agt ctc tgc gtg gtg gag gtt cgc cac ggg ccg tcc agt gtt gaa atg 1632 Ser Leu Cys Val Val Glu Val Arg His Gly Pro Ser Ser Val Glu Met 530 535 540 ggc cat gag ctc ttc aaa ttg gcc cag atc ttt ttc aac ggg 1674 Gly His Glu Leu Phe Lys Leu Ala Gln Ile Phe Phe Asn Gly 545 550 555 tgagtccctt tcccacttca cagggcacac actgttcctt tcctaggctc ttctgggtat 1734 tacttttttt ctatggtgtt tttaaaagca tgttgaaact tctttatttc ctctttagga 1794 gagatctttg ccttctgttt tgctaacaaa cataacgctt tagaatttcc tcctgggagg 1854 cggagcttgc agtgagccaa gatcgcgcca ctgcactgta gcctgggcga cagagcgaga 1914 ctccatctca aaaaaaaaaa aaaaaagaat ttcctcctgg gagatatggg gaaagctttt 1974 agatctcaag tgagtttccc agagagaact tggccaggca gccccaccca cactccagta 2034 tagctctcct tctggttgtt ctctggttcg tcacagcccc tttggctgtc tcattcccag 2094 cactctcagc tccaggctct ctgccttctc cctactctgc atcctcttcc ttttaaagca 2154 tttgcttgaa ccagggctga ttttaccccc agacaacatg tggcattgcc tggagacttt 2214 tttttttttt tttttgagaa ggggtcttgc tgtcttgccc aggctggagt acagtggctc 2274 ggtcacagct cactgcttcc tgcaactcct gggctcaagc gatctctgga gatattttgg 2334 attgtcatga cttggaaggg ggttgctgct ggcatctatt cgaaagaggc cagaggtgct 2394 gctaagcatc ctcccgggta caagacagtg ccccccccac caaccccagc aaagaaggag 2454 ccagcaacag tgtcaatagt gtcagggtcg agaaaccctg cttttttgct gctgttgttt 2514 gttttttgtt ttaaatcccc tgttctactt tgaaggttaa aaggaaagaa cagcacgctg 2574 atgagctgat gccaaatcca cttttgctac tgagaccatt tagggcccaa tttcaggatt 2634 tccgggtgga acctccaacc ctggtaaagc tgcccttggt gtatgtggct atgagaaagt 2694 gcttaaagct tcaacctaag gctgtgctga gtgggcctgg tacccaagac acagagacat 2754 tctgtttggt cagagagaga gaaaagggct gcagagttag gtcagaggtc agccctaaga 2814 tggtcaccct aaaatgaaaa ctgctatgta aacctgtggt aaataccaga tgaaaacttt 2874 gaggccgggt gtggtagctc acgcctgtaa tccagctgcc caggaggttg aggcaggaga 2934 atcacttgaa cccgggaggc ggaggttgca gtgagccgag gtcgcacaaa tacctgggcg 2994 acaagagtga aactcttgtc tc 3016 <210> 27 <211> 3228 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2158)..(3228) <400> 27 attttttgta ttttcagttg aaacgaggtt tcaccatatt ggccaggctg gtctcgaact 60 tctgacctca ggtgatccac cccccgcctc gtcctccaaa agagctggga ttacaagtgt 120 gagccaccgc gcccggccca gttgtggact ttaacagagg gaagctttaa acatgtttaa 180 ccacaggccc aatttgaaca aagatacttc aatcattata gagaggaaaa cagtactttt 240 tgttcaattg tgcaaactct ccaagtatct aatggagaag tagagaagaa ccctaatgaa 300 actgagtgtg aatgaggctc agctaggctt ctacttgggt tcactttctc atctgtctgc 360 ctgtcctggg attgaccctc gctcctctga agaccagcct gaaagcctta aaactggtca 420 gatgatggat gagtctgatg aggactttaa agaactctgc gctagctttt tccaaagggt 480 gaaaaaacat ggaatcaagg aagtgtcagg agaaaggaag acacaaaagg ctgcctcaaa 540 cggcactcag ataagaagca aattgaaaag gaccaaacaa actgctacca agaccaaaac 600 ccttcaaggc cctgcagaga agaaacctcc gtctggcagc caggccccta ggactaaaaa 660 gcaaagggta accaaatggc aagcaagtga accggcccac tctgtgaatg gggagggggg 720 tgtgcttgcc tctgctccag atccacctgt gctccgggaa acagcacaaa acacccagac 780 gggtaaccag caagaaccat cgccaaacct ttccagagag aaaaccagag agaatgtgcc 840 caacagcgac tcccagcctc ctccttcctg tttgacaaca gcagtgccaa gtccctccaa 900 accccgcaca gcacaattgg tcctacagcg aatgcagcag ttcaagagag cagaccccga 960 gcgtttgaga cacgcttcag aagagtgctc cctcgaggct gcgcgggaag aaaatgtccc 1020 aaaggatcct caagaggaga tgatggcggg gaatgtgtat gggcttgggc cccctgcccc 1080 agagagcgac gctgcggtgg ccttgaccct gcagcaggag tttgcacggg taggagcatc 1140 ggcacatgat gatagcctgg aggaaaaggg tttgttcttc tgccagattt gtcaaaagaa 1200 cctctcagcc atgaacgtga cccgaaggga acagcatgtg aacaggtggg ggcagcttgg 1260 gccgtcgcct ctcccgtgta tgtgaccaga atccccaagc accccagggc tggagtgcgg 1320 atctccacac cttaccatga caacagcacc tcagctttgt tgtcaaccta ccccttttta 1380 aaaataactt cgttgagata caattcacag aacatatagt tcacccattt aaactgaaca 1440 aatcactact tttgggatat tcacacagtt gggcaactgt caccacaatc acttctggat 1500 tattttcatc acccccaaaa gaatccccac acccattggc agccactccc tattgcccct 1560 ctctcccctg acaaccacta atcaacattc tgtctggatg gatttgccga ttctgaaatt 1620 gcacagttgt ccttttgtgt ctgccttctt tgacttaata tgttgttttt gaggttcatc 1680 catgttgtag catggagcag gcttcattcc tttttatggc tgagcagtat ctcattgtat 1740 ggctagactg tgtttttccc attcttagat gaggaatatg accatggttt atcctttcgt 1800 ccattggcgg acatttggag catttctacc ctttgggatt gtggatagag ctgccgtgaa 1860 catgggtttc atgtatttgt ttgggtacct gctttcagtt ctttggggtc tctacttagg 1920 agtggaattt ctaagtcatc atgtaactgc atttaatctt tccttgcttt ctttagccaa 1980 ctttgctgac agatacctaa gtgtagtgtc taggggctga ctgccgggag acggagccag 2040 gctgtgtaga ggggattggc tttggggaac ttgctttgac cacagcacgt ctgtgttgac 2100 ctggacccac atttgctcca atccacattc ctggggaggg tggttctcct gtattga 2157 ctg ttt tcc ttc agg tgc ttg gat gaa gct gaa aag aca cta aga cct 2205 Leu Phe Ser Phe Arg Cys Leu Asp Glu Ala Glu Lys Thr Leu Arg Pro 1 5 10 15 tct gtg cct cag atc cct gag tgc ccg att tgt ggg aaa ccg ttt ctt 2253 Ser Val Pro Gln Ile Pro Glu Cys Pro Ile Cys Gly Lys Pro Phe Leu 20 25 30 acc tta aag agc aga acc agt cac ttg aag cag tgt gct gtg aag atg 2301 Thr Leu Lys Ser Arg Thr Ser His Leu Lys Gln Cys Ala Val Lys Met 35 40 45 gag gtt ggc ccc cag ctc ctg ctt cag gct gtg cgg ctg cag aca gca 2349 Glu Val Gly Pro Gln Leu Leu Leu Gln Ala Val Arg Leu Gln Thr Ala 50 55 60 cag cct gag ggt agc agc agc cca ccc atg ttc agc ttc agt gat cac 2397 Gln Pro Glu Gly Ser Ser Ser Pro Pro Met Phe Ser Phe Ser Asp His 65 70 75 80 agt aga ggt ctg aaa cgg aga gga ccc acc agc aag aag gag cca cgg 2445 Ser Arg Gly Leu Lys Arg Arg Gly Pro Thr Ser Lys Lys Glu Pro Arg 85 90 95 aag agg cgg aag gtg gac gag gca ccg tcc gag gac ctg ctg gtg gcc 2493 Lys Arg Arg Lys Val Asp Glu Ala Pro Ser Glu Asp Leu Leu Val Ala 100 105 110 atg gct ctg tcc cgg tcg gag atg gag ccg ggt gcg gct gta cca gcg 2541 Met Ala Leu Ser Arg Ser Glu Met Glu Pro Gly Ala Ala Val Pro Ala 115 120 125 ctc agg ctg gaa agt gcc ttt tct gag agg ata aga cca gaa gca gag 2589 Leu Arg Leu Glu Ser Ala Phe Ser Glu Arg Ile Arg Pro Glu Ala Glu 130 135 140 aat aaa agt cgc aag aag aaa ccc ccg gta tcc ccc cca ttg ttg tta 2637 Asn Lys Ser Arg Lys Lys Lys Pro Pro Val Ser Pro Pro Leu Leu Leu 145 150 155 160 gtc cag gac tct gaa acc aca ggc cga cag ata gag gac cgt gtg gcc 2685 Val Gln Asp Ser Glu Thr Thr Gly Arg Gln Ile Glu Asp Arg Val Ala 165 170 175 ctg ctc ctc tct gag gaa gtg gaa ttg tct agc acg cca cca ctt cct 2733 Leu Leu Leu Ser Glu Glu Val Glu Leu Ser Ser Thr Pro Pro Leu Pro 180 185 190 gcc agc agg att tta aag gaa ggg tgg gaa aga gcg ggc cag tgt cct 2781 Ala Ser Arg Ile Leu Lys Glu Gly Trp Glu Arg Ala Gly Gln Cys Pro 195 200 205 cct cca cct gaa cgc aag cag agc ttt ctg tgg gag ggc agc gca ctg 2829 Pro Pro Pro Glu Arg Lys Gln Ser Phe Leu Trp Glu Gly Ser Ala Leu 210 215 220 act ggg gcc tgg gcc atg gag gac ttc tac acg gcc agg ctg gtc cct 2877 Thr Gly Ala Trp Ala Met Glu Asp Phe Tyr Thr Ala Arg Leu Val Pro 225 230 235 240 cct ctc gtg ccc cag cgg cct gcc cag ggc ctt atg cag gag ccc gtg 2925 Pro Leu Val Pro Gln Arg Pro Ala Gln Gly Leu Met Gln Glu Pro Val 245 250 255 ccg cct ctg gtg cca cct gag cac tca gag ctg agc gag cga agg tca 2973 Pro Pro Leu Val Pro Pro Glu His Ser Glu Leu Ser Glu Arg Arg Ser 260 265 270 ccc gct ctc cac ggc acc ccc act gca ggc tgt ggc tcc agg ggc ccg 3021 Pro Ala Leu His Gly Thr Pro Thr Ala Gly Cys Gly Ser Arg Gly Pro 275 280 285 tcg cct tcg gcc agc cag agg gag cac cag gcc ctg cag gac ctc gtg 3069 Ser Pro Ser Ala Ser Gln Arg Glu His Gln Ala Leu Gln Asp Leu Val 290 295 300 gac ctg gcg agg gag gga ctg agc gcc agc ccg tgg ccc ggc agt ggg 3117 Asp Leu Ala Arg Glu Gly Leu Ser Ala Ser Pro Trp Pro Gly Ser Gly 305 310 315 320 ggc ctg gct ggc tcg gaa ggg act gca ggg ttg gac gtg gtg ccc ggc 3165 Gly Leu Ala Gly Ser Glu Gly Thr Ala Gly Leu Asp Val Val Pro Gly 325 330 335 ggc ctt cct ctg act ggg ttt gtg gtg cca tcg cag gac aag cac ccg 3213 Gly Leu Pro Leu Thr Gly Phe Val Val Pro Ser Gln Asp Lys His Pro 340 345 350 gac agg ggc ggc cgc 3228 Asp Arg Gly Gly Arg 355 <210> 28 <211> 3458 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (593)..(1213) <400> 28 ctgtctcaat aaaaaaaaag aaaagttaaa caattaactt tttaaaagag tataaatgag 60 aaaaagatat tttatatgtg ctaatcttct gcctacatga tgaaaaagag aaggtacagt 120 ttaccaatga gagaatgaga gatgtaggca cagtggcgtg tgcctatact ctcatctatt 180 tgagaatctt aggtgggagg atcacttgaa tccaggagtt tgagaccagc aggggaacat 240 agtgagaccc tatctcttta ataataaaaa aaaagaatgt gaggacctca atgcagatct 300 tttagacatt aaaaggataa gtaaaattat gaacattatt atgccaataa tttttttttt 360 tttttttttt gagacagcgt ctatctctgt tgcccgggct ggagtgcggt ggcgcgatct 420 cagcccactg caacctccat ctcccgggtt caggcgattc tcctgcccca gcctcccagg 480 tggctgggat tataggtgtg tgccaccaaa cctagctaat ttctgtattt ttagtagaga 540 cggggttttg gcatgttggt cgggcaggtt tcgagctcct gacctcaggt ga cct gcc 598 Pro Ala 1 tgc ctc agc ctc cca agg tgc tgg gat tgc agg tgt gag cca cca cgc 646 Cys Leu Ser Leu Pro Arg Cys Trp Asp Cys Arg Cys Glu Pro Pro Arg 5 10 15 cca gcc tat gcc aat aac ttt tac agc tta gat ata atg gac aaa ttc 694 Pro Ala Tyr Ala Asn Asn Phe Tyr Ser Leu Asp Ile Met Asp Lys Phe 20 25 30 cat gaa aaa cac aaa cca tca aaa ttc cct cga gaa caa ata gag aac 742 His Glu Lys His Lys Pro Ser Lys Phe Pro Arg Glu Gln Ile Glu Asn 35 40 45 50 cta aat aac ttt aca tta aga act tgg tct ttt cct ctt gga agc ccc 790 Leu Asn Asn Phe Thr Leu Arg Thr Trp Ser Phe Pro Leu Gly Ser Pro 55 60 65 ctc tct ctc act aga gag aga gct gat ttc ctt tct tta tct ttc tct 838 Leu Ser Leu Thr Arg Glu Arg Ala Asp Phe Leu Ser Leu Ser Phe Ser 70 75 80 ctt ttg cct gtt aaa cct cca ctc cta aat tcc tca tgt gtg tcc gtg 886 Leu Leu Pro Val Lys Pro Pro Leu Leu Asn Ser Ser Cys Val Ser Val 85 90 95 tcc aaa att ttc ctg gca cga gat gat gaa cct cag gta ttt acc cca 934 Ser Lys Ile Phe Leu Ala Arg Asp Asp Glu Pro Gln Val Phe Thr Pro 100 105 110 gac aac gta gct gct tca tac tgg gga cct cgt ccc aga tat caa ggt 982 Asp Asn Val Ala Ala Ser Tyr Trp Gly Pro Arg Pro Arg Tyr Gln Gly 115 120 125 130 aca gca ttc atc aaa acg caa cat ctg gtg gag gca aac cag tgt tac 1030 Thr Ala Phe Ile Lys Thr Gln His Leu Val Glu Ala Asn Gln Cys Tyr 135 140 145 aac cca tcg gaa tgg cta aca gca atc aaa ctc caa atg gtg ctg cag 1078 Asn Pro Ser Glu Trp Leu Thr Ala Ile Lys Leu Gln Met Val Leu Gln 150 155 160 aca gaa cca cac atg gac gtg cct ttc ttc cga gga ctc tta gat cgg 1126 Thr Glu Pro His Met Asp Val Pro Phe Phe Arg Gly Leu Leu Asp Arg 165 170 175 ccc cag gag gag ccc tac ctg ctg ttc ccc aca caa cac ctc ttt tca 1174 Pro Gln Glu Glu Pro Tyr Leu Leu Phe Pro Thr Gln His Leu Phe Ser 180 185 190 gca gga agt agc cag aaa gag tcc tcg tcc aac agc ccc taatagtagt 1223 Ala Gly Ser Ser Gln Lys Glu Ser Ser Ser Asn Ser Pro 195 200 205 tagggttacc actccagagc ggggaatgat acaggtgtta agaagaaatt acttaggtgg 1283 atactgaggg tacagaagtc cttggtaagg ttttccattt aatgaaaagc agccccaaat 1343 tattttcttt ctaacaaaga gcagcctgta aaattcagtt gcagacatag atgttagcag 1403 ttatgaaatc atgttcaaga tgggagcttc atcttccctt cgctttgtca accatatgta 1463 cagtaaggag cagacaagat ggcaccagcc aaggggaaag ttcatttgca taataacatt 1523 agggtggggt agccagcctt cccctaaagc tatgtaaaca tcatacctga ttgaaccaat 1583 ctgtaatccc tatgtaaatc agacgccgcc gcctcaagcc tgagtaaaat ccagcacatc 1643 tgccaccaac tggtctggga gtcccctctc tcacgagaga gagctgtttt actttctctt 1703 tctttctttt ttttttcttt ttttcctatt aaacctttgc tcctacactc cttaaaaaaa 1763 aaaaaaaaga aagaaattga atttgtagtt tcaaaaatct ttcaacaaag aaaacttaag 1823 gtctagatgg tggccttact agtaaattat agcaaacatt taaggaggaa ataataccaa 1883 ttatacacac agtctttcag aaaatgggag gaagcactta ccagctcgtt ttatgaagcc 1943 agcattatac taatatcaaa accaaataaa gacatgagaa gcatagaaag ttacagcccc 2003 agtatccatc atgaacatag atgtaaaaat attctataaa acttaagcaa gtttaagtca 2063 agagatacat aaaaagaata atacatcatg aacaaatggg gttcacttga aaatcagtgc 2123 agtccactat attagtagac taaaaaataa ccacatgatc tcaagatata gcagaaaaat 2183 catttgtcta aattatcaaa aacctaggct atgcattctc atcaggtgaa aattggctct 2243 tgcttgggag ggagaatcta aaatgttaac aattttttgt gccctttcag ggggccataa 2303 tacataaaca gatatacagt atatctggta ttaaaatttc ttgggtggag agcacaatga 2363 ccacaaaaca aagtctgaaa aggctctttg gagaatgata atgaaataat gtttgaaaaa 2423 cacaactatg tataagtaga atatcatata atatgaaaga ttgacttctt cctcttaggt 2483 tcaggaacaa agcaaggatg tcagcttttg taacttctat tcagtatttt actggagtta 2543 gtggtcagta tgaagaaata aaagggaaaa aggggaaaag gaaaacaaaa gaagagacat 2603 acagattgga aagaagtaaa atgattttta ttctcagaca acatgatcat ctatgtagaa 2663 atccagagat ctacaaaaaa gctaatatta taatgagttt tttcaatatt acatgataca 2723 aagtcaacat acaaagatca attatttttc tgtatgatag caatgaacaa ttagaaattg 2783 aaatgtaatg ggaggttgaa gcaggagaat tccttgaacc tgggaggcag aagcttcagt 2843 gagccgagca tcataaaatc atgaagtgct tagggacaaa tttagccaat acctacaaga 2903 cacatacact gaagactaca acatattact gagagaaatt aaagaatacc taaataaatg 2963 aagagatata ccatatttgt ggatccaaag attgaatatg ggctgcgtgt ggtggctcat 3023 gtctgtaatc ctagcacttt gggaaactga agtgggagaa tcacttgagg ccaggagttt 3083 gagaccagcc tgggcaacac agcaagatcc catctctaca aaaaaattgt taaaagataa 3143 agaaaaaata acaataatga aaaataggcc gagcgccgtg gctaactcac gcctgtaatc 3203 ctagcgcttc gggaggccga ggcaggcaga tcacctgagg tcgggagttc gagaccagcc 3263 tgaccaacat ggagaaaccc tgtctctact aaaaatacaa aattagccag gcatggtggc 3323 acatgcctgt aatcccagct tctcgggagg ctgaggcagg agaattgctt gaacccggga 3383 ggcagaggtt gcagtgagct gagatcgtgc cattgcactc tagcctgggc aatgagcgaa 3443 actccttctt aaaag 3458 <210> 29 <211> 3326 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2)..(979) <400> 29 g aag gaa ggg cac cgc caa gat gga gag ggg gcc tta gca gct cct gaa 49 Lys Glu Gly His Arg Gln Asp Gly Glu Gly Ala Leu Ala Ala Pro Glu 1 5 10 15 gct gag cca gca gga aag gtg cag gcc cct gag ggg ctg atc cca gcc 97 Ala Glu Pro Ala Gly Lys Val Gln Ala Pro Glu Gly Leu Ile Pro Ala 20 25 30 aca ggc cag gca gag gag cta gca gcc aaa gat cac gac tcc tgc gca 145 Thr Gly Gln Ala Glu Glu Leu Ala Ala Lys Asp His Asp Ser Cys Ala 35 40 45 gga ctg gag ggg aga gct gaa ggg caa gga gga gtg gat gtc gtg cta 193 Gly Leu Glu Gly Arg Ala Glu Gly Gln Gly Gly Val Asp Val Val Leu 50 55 60 agg acc cag gaa gct gtt gct gag gaa gat ccc ata atg gca gaa aag 241 Arg Thr Gln Glu Ala Val Ala Glu Glu Asp Pro Ile Met Ala Glu Lys 65 70 75 80 ttc agg gag gaa gcg gtg gat gag gac cca gag gag gaa gag gac aaa 289 Phe Arg Glu Glu Ala Val Asp Glu Asp Pro Glu Glu Glu Glu Asp Lys 85 90 95 gag tgc act ctg gag aca gaa gcg atg cag gac agg aac tcg gaa ggg 337 Glu Cys Thr Leu Glu Thr Glu Ala Met Gln Asp Arg Asn Ser Glu Gly 100 105 110 gac ggg gac atg gaa gga gaa gga aac aca caa aag aat gag ggc atg 385 Asp Gly Asp Met Glu Gly Glu Gly Asn Thr Gln Lys Asn Glu Gly Met 115 120 125 gga gga gga agg gtt gtg gct gtg gaa gtt cta cac gga ggt ggt gaa 433 Gly Gly Gly Arg Val Val Ala Val Glu Val Leu His Gly Gly Gly Glu 130 135 140 acg gca gaa aca gcc gca gag gag agg gag gtg ttg gca ggt tcg gag 481 Thr Ala Glu Thr Ala Ala Glu Glu Arg Glu Val Leu Ala Gly Ser Glu 145 150 155 160 aca gcc gag gag aaa aca ata gca aat aaa gcc tcc tcc ttt tca gat 529 Thr Ala Glu Glu Lys Thr Ile Ala Asn Lys Ala Ser Ser Phe Ser Asp 165 170 175 gtt gct gag gaa gaa acc tgg cac caa cag gat gag tta gta gga aaa 577 Val Ala Glu Glu Glu Thr Trp His Gln Gln Asp Glu Leu Val Gly Lys 180 185 190 aca gca gct gca ggg aag gtg gtg gta gag gaa tta gca cgg agt ggg 625 Thr Ala Ala Ala Gly Lys Val Val Val Glu Glu Leu Ala Arg Ser Gly 195 200 205 gag gaa gtg cca gca gca gag gag atg aca gtg aca tat aca aca gag 673 Glu Glu Val Pro Ala Ala Glu Glu Met Thr Val Thr Tyr Thr Thr Glu 210 215 220 gct ggg gtg ggc act cca gga gcc ctg gag cgg aag acc tca ggg cta 721 Ala Gly Val Gly Thr Pro Gly Ala Leu Glu Arg Lys Thr Ser Gly Leu 225 230 235 240 gga cag gag caa gag gaa ggg tca gag ggc cag gag gca gcc act ggg 769 Gly Gln Glu Gln Glu Glu Gly Ser Glu Gly Gln Glu Ala Ala Thr Gly 245 250 255 agt ggc gat ggg agg cag gag aca gga gca gct gaa aaa ttc cga tta 817 Ser Gly Asp Gly Arg Gln Glu Thr Gly Ala Ala Glu Lys Phe Arg Leu 260 265 270 gga tta tca cgg gag gga gag agg gaa ttg agt ccg gag agt cta cag 865 Gly Leu Ser Arg Glu Gly Glu Arg Glu Leu Ser Pro Glu Ser Leu Gln 275 280 285 gcg atg gca aca ctt cca gtg aag cct gat ttc act gaa acc cga gag 913 Ala Met Ala Thr Leu Pro Val Lys Pro Asp Phe Thr Glu Thr Arg Glu 290 295 300 aag caa cag cat atg gtg caa gga gaa agc gag act gca gat gtt tcc 961 Lys Gln Gln His Met Val Gln Gly Glu Ser Glu Thr Ala Asp Val Ser 305 310 315 320 ccc aac aac atg cag gtc taggagactt gctggcagac ggataattta 1009 Pro Asn Asn Met Gln Val 325 aagatgtctt ctgaagatgt aaagagtgga gaaagattca cgcaagcatc tcaccaggat 1069 tcttgatttt ctctctctcc tctttagttg ctggttgcgc ttgtctgaga tgattcccaa 1129 tctgtcagcc ctggtcagta gctcagtaag caccttgaga atagctcaag tagatctgta 1189 ggacccttct tagaagcagt ggttcctcat ggagaaactt gtgaggctgt tacacattct 1249 acacacctaa cattattttc aaacaaaaat gataattttc agatgcttga cttttaccaa 1309 agatcactgg aaggcccagt cctaatgtta ggggtttgtt taaagtcctt tttattttac 1369 aatacagagc cccagtcaat tccacaatct caatttcata catgggaatt ttatttaaaa 1429 atctgtggtt tggggcttta atgaattggc ctgtgaaaat gagctctaaa tttcctccca 1489 cgtacactca aaactcaaga ttgctccaaa tctctaagtt cttccagcaa aagatttctt 1549 ggcatgtata ttcacttata cttagaaata ttcattcttt taatttatgc cagaataaca 1609 aagtggaaat cttatttcaa aatgctcttt gtttttttgt gtgtgtttct gtagttctgc 1669 tttctggggt agactagtaa aatggtagct tccagcattt tgtccctggg gccttcttta 1729 tagggccact caaatttaaa taaaagtagt aaataattta gctaagtgga ataagtataa 1789 taattatagt ggtaagcata gcacatcagc attatgccaa cattctagac tctttagttg 1849 atgtcattaa atggaaaaga aacttggatt aaatgagtgt gctgctcacc ttcccaagtt 1909 ctgttatttc aaacctgtga actaaccttg cagttcatta taaatcaaca gtaacaactg 1969 cattctaaat tactccctga tattattttc tagttgtgta tcagcctgtc tcctaggggt 2029 tttcatttcc ctgaagacat acaagtgccc cagagcgcat gtatatgtct accatttctc 2089 tatatgagaa ggtaaaaaaa atttccttaa gcagtgattt tccagccaga atatacatta 2149 gattttcatg ggacgctttt ataaatgact caaccctttt ccccacccca gagattcaga 2209 cttaattcgt tttagatgga tctacacatc agtatatata tatttttaac ttttcacttg 2269 attcttctct gtagccaagg ttgagaaccg ctgttctaaa tcatcatata atccatgctg 2329 gccacattac actcaaggtc cctagggacc aggcatatta tcatagtagg tattttccat 2389 tttaatgtgt aatggagcca ttcaatgatc aaaaatacac tggaccagat agtagactgg 2449 tcccttgatc agaagcatca gcacatcagc atcacctgga aattgttccc agcctttgtc 2509 tcctacctac taaattagaa actcttggtg ggttccagta atccatagct taacaagccc 2569 tgcagttaat actgatgtac actgatgtcc aaaaactgct gtcatggact attgattgta 2629 ttgaggatta gtctcagttg gaaagccaac tacagaggca ttttgaactt tctttctttg 2689 cctctctatg tctctctgtc ttttcctgtc ttctgattta tctgtctttc tttctctagt 2749 aaatggcact caatataaaa gtggtggagt caatcttaaa cttattttta ttatgattgt 2809 attgatacat gcacgaagtc cctctgccct actccctatt caaggatatt actcactgca 2869 catcataaat ctccatcatc tgtcttaaag ttttatgagt agatttcatc tacattatat 2929 tcaagttcat ttattactga gctgtattac tgtggagctc taacagtatt tgtttcctga 2989 tttcaaactc aatgctacag agcactttga atacatcaca ccttatagga aagatagtaa 3049 atgtattaat cccattgaaa aattagtttt gtacaatgtg ctaaatagta ttgcattgga 3109 ttacttttat atttaacaca ctccatcaaa acatcccata acataatttt acaatctgca 3169 tgtgaattta actgtgaaat tcagtattgt gatattttga ataagtgaat tctttctctg 3229 caaatactat gttgataaaa ttacttgtat gttcccctga aatggtttgt ttcctgtttc 3289 ttcattatta aaacataaat caatcatatg tttacag 3326 <210> 30 <211> 3386 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3)..(1544) <400> 30 aa aat gtt tct tac atg tgc cag cca ggc tac acg atg gaa ttg aat 47 Asn Val Ser Tyr Met Cys Gln Pro Gly Tyr Thr Met Glu Leu Asn 1 5 10 15 ggc tcc aga atc agg act tgt aca att aat ggc aca tgg agt gga gta 95 Gly Ser Arg Ile Arg Thr Cys Thr Ile Asn Gly Thr Trp Ser Gly Val 20 25 30 atg cca act tgt aga gct gtt acc tgc cca act cct ccc cag atc tct 143 Met Pro Thr Cys Arg Ala Val Thr Cys Pro Thr Pro Pro Gln Ile Ser 35 40 45 aat gga agg ctg gaa gga aca aat ttc gac tgg ggc ttt agt att agc 191 Asn Gly Arg Leu Glu Gly Thr Asn Phe Asp Trp Gly Phe Ser Ile Ser 50 55 60 tac atc tgt tct cca ggc tat gag cta tcc ttc cct gct gtt ttg acc 239 Tyr Ile Cys Ser Pro Gly Tyr Glu Leu Ser Phe Pro Ala Val Leu Thr 65 70 75 tgt gta ggg aat ggt acc tgg agt ggt gaa gta ccg cag tgc tta cca 287 Cys Val Gly Asn Gly Thr Trp Ser Gly Glu Val Pro Gln Cys Leu Pro 80 85 90 95 aag ttt tgt ggt gac cct ggt ata cct gcc caa gga aaa aga gaa ggc 335 Lys Phe Cys Gly Asp Pro Gly Ile Pro Ala Gln Gly Lys Arg Glu Gly 100 105 110 aaa agc ttt ata tac cag tca gag gtt tca ttc agc tgc aat ttt cct 383 Lys Ser Phe Ile Tyr Gln Ser Glu Val Ser Phe Ser Cys Asn Phe Pro 115 120 125 ttc ata tta gtg gga tca agc acc aga ata tgt caa gca gat ggc act 431 Phe Ile Leu Val Gly Ser Ser Thr Arg Ile Cys Gln Ala Asp Gly Thr 130 135 140 tgg agt ggt tca tca cct cac tgc ata gag cct acc caa acc tct tgt 479 Trp Ser Gly Ser Ser Pro His Cys Ile Glu Pro Thr Gln Thr Ser Cys 145 150 155 gaa aac cca ggt gtg cct cgg cat gga tct cag aac aat aca ttc gga 527 Glu Asn Pro Gly Val Pro Arg His Gly Ser Gln Asn Asn Thr Phe Gly 160 165 170 175 ttt caa gta gga agt gtt gta cag ttc cat tgc aaa aaa gga cac ctt 575 Phe Gln Val Gly Ser Val Val Gln Phe His Cys Lys Lys Gly His Leu 180 185 190 ctc caa ggg tct aca aca cgc acc tgc ctc cct gat ctt acg tgg agt 623 Leu Gln Gly Ser Thr Thr Arg Thr Cys Leu Pro Asp Leu Thr Trp Ser 195 200 205 ggg att cag cct gaa tgc ata ccc cac agc tgt aaa cag cca gaa act 671 Gly Ile Gln Pro Glu Cys Ile Pro His Ser Cys Lys Gln Pro Glu Thr 210 215 220 cct gct cat gca aat gtc gta ggg atg gac ctt cca tct cat ggg tat 719 Pro Ala His Ala Asn Val Val Gly Met Asp Leu Pro Ser His Gly Tyr 225 230 235 aca ctg att tat acc tgt cag cct ggc ttc ttc tta gca ggt gga aca 767 Thr Leu Ile Tyr Thr Cys Gln Pro Gly Phe Phe Leu Ala Gly Gly Thr 240 245 250 255 gaa cat aga gtg tgt aga tcc gat aac acc tgg act gga aaa gtt ccc 815 Glu His Arg Val Cys Arg Ser Asp Asn Thr Trp Thr Gly Lys Val Pro 260 265 270 att tgt gaa gct ggt tct aaa ata ttg gtg aaa gat cct aga cct gca 863 Ile Cys Glu Ala Gly Ser Lys Ile Leu Val Lys Asp Pro Arg Pro Ala 275 280 285 ctg gga aca ccc agc cca aag cta agt gtt cct gat gat gta ttt gcc 911 Leu Gly Thr Pro Ser Pro Lys Leu Ser Val Pro Asp Asp Val Phe Ala 290 295 300 caa aat tat ata tgg aaa ggc tct tac aat ttc aaa gga agg aaa caa 959 Gln Asn Tyr Ile Trp Lys Gly Ser Tyr Asn Phe Lys Gly Arg Lys Gln 305 310 315 ccc atg acc tta aca gtt act agt ttc aat gct tcc act ggg aga gtt 1007 Pro Met Thr Leu Thr Val Thr Ser Phe Asn Ala Ser Thr Gly Arg Val 320 325 330 335 aac gca aca ctg agc aat agc aac atg gag ctg cta ctt tca ggg gta 1055 Asn Ala Thr Leu Ser Asn Ser Asn Met Glu Leu Leu Leu Ser Gly Val 340 345 350 tat aaa agc cag gaa gct cgc cta atg tta cgc ata tat ctt att aaa 1103 Tyr Lys Ser Gln Glu Ala Arg Leu Met Leu Arg Ile Tyr Leu Ile Lys 355 360 365 gta cct gct cat gct tct gtg aag aaa atg aag gaa gaa aat tgg gca 1151 Val Pro Ala His Ala Ser Val Lys Lys Met Lys Glu Glu Asn Trp Ala 370 375 380 atg gat ggc ttt gtt tct gct gag cct gat gga gct act tat gta ttt 1199 Met Asp Gly Phe Val Ser Ala Glu Pro Asp Gly Ala Thr Tyr Val Phe 385 390 395 caa gga ttt att caa ggc aaa gat tat gga caa ttt ggc cta caa aga 1247 Gln Gly Phe Ile Gln Gly Lys Asp Tyr Gly Gln Phe Gly Leu Gln Arg 400 405 410 415 ctg gga ctg aat atg tca gaa ggt tca aat tct tca aat caa cct cat 1295 Leu Gly Leu Asn Met Ser Glu Gly Ser Asn Ser Ser Asn Gln Pro His 420 425 430 ggt aca aat agt agt tct gta gcc att gct att ctt gtg cct ttt ttt 1343 Gly Thr Asn Ser Ser Ser Val Ala Ile Ala Ile Leu Val Pro Phe Phe 435 440 445 gca ctt ata ttt gca gga ttt gga ttt tat ctt tat aaa caa agg act 1391 Ala Leu Ile Phe Ala Gly Phe Gly Phe Tyr Leu Tyr Lys Gln Arg Thr 450 455 460 gca cct aaa aca cag tat aca gga tgt tca gtt cat gaa aat aac aat 1439 Ala Pro Lys Thr Gln Tyr Thr Gly Cys Ser Val His Glu Asn Asn Asn 465 470 475 ggc caa gca gct ttt gaa aat ccc atg tat gac acc aac gca aag tca 1487 Gly Gln Ala Ala Phe Glu Asn Pro Met Tyr Asp Thr Asn Ala Lys Ser 480 485 490 495 gtg gaa ggg aag gcg gta cga ttt gat ccc aac ttg aac acg gtt tgc 1535 Val Glu Gly Lys Ala Val Arg Phe Asp Pro Asn Leu Asn Thr Val Cys 500 505 510 aca atg gta taacgaggca acctttgcct tcttcagaag cttggaaatc 1584 Thr Met Val gacacacaaa acagtgcaca tttagttcac tgctaaacaa attaaagcac acttttcagg 1644 acttgctggg tcaccttttc ctgaggaatg atacagaaga gtgttttttc ataaactgga 1704 ccataattct tcatgtttac catggagagt tttacagaaa tttggctgca ctctgagagt 1764 gcttactcac agtttatttg ctttttttaa aaaggagatt attctaaaat ataaacttat 1824 ttgcatatat tggaggagca tccactatca gtatttctgt gctttataaa ctatattaga 1884 gggactgggt ttaaaaaaaa agatataggg tagaaataag agctatactt acaagagtca 1944 atagatcact gacttctctt taactgtcct gagctacatc acgcccacaa atctgtcttt 2004 cataccactc tatctgccat tcattcttgt taaatgaggc attgttttct ttatttaaga 2064 ttgagttatg actttaaatg tttatgagct agtttatgcc tcggaagaca taaggtttcc 2124 cattccaatt tgaatctttc tatttcttta gcatcatatt gctcttcttc ttttagactg 2184 gttgtcatag tttctgcaaa gggcaagttc attgtgctac cctcccaatt cccccattat 2244 ggagtaacca gtattattca gtgagctatg gggtagtgtt tcactccttg cttcaatatg 2304 gttttttcct atttattttt attatttttt aatcccaaat gtgatagtag cttcagtatg 2364 tttcctcacc caaaaaccat ttggctggca gaaattatct agaaaaatta ttattttgca 2424 gttatctgag acaccaaact taccatcctt tattttacaa tatttttgat cgaccaaata 2484 aaatgtccta ataatctact ctatttatat ctacatttcc ttccagctga gtcttcaaat 2544 ttagcattat tttgacactt ttaattttca tttaacaatg gattagaaaa atattttggt 2604 ctagccacta aacataatga ctgaaaaaaa ttattattat aaatcaccaa tataaattta 2664 ttgcctacaa ttgtggactt atcatatttt tatatatttt taaatttctg tacctttatt 2724 gttaaacacc aagtttcaca tacaagaggt ttctttcatt gtcaaattaa gatatgtatt 2784 tgtaagttat tggtggctca tttaaactgt atcatacagt aatgccagca tttttattta 2844 ataggtcatc gtcttccttt tatagctgtt ttacttcatt gaatacgatc atgtacccag 2904 tgttaactct ttgttgttgt ccctttcaaa tatggataac tctgtgaaca gtcttgactt 2964 tttgtatcat gagacagagt gcctaagaga aacccttgca cctgggagcg ctgcttggct 3024 ctatctctac aacatttaat gaatttcttg taaaccactt tgagatacat tgttttggaa 3084 attcatacaa ttttctcaac atggtactct actggcagga tgcagtttta aattttatgc 3144 catcagttat ttattcttgt ttattcaaat gactgcaata acaatgattc attcattaat 3204 gttaaggcta atacatttaa gatcttgttt aaacaatgtt tcttctgcaa ctggctactc 3264 ctcttatatt aatgcataca cttttgtaaa gaagtatatt tttatgaaaa gaaactttgt 3324 aaaagtatga tgtaaatttt cagtgcaatg taaacaaaat aaaaatggat aattgctttt 3384 gt 3386 <210> 31 <211> 3515 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (1)..(2112) <400> 31 gtt ctc ggt ggt ctc ctc ctg ctt gga gtt gct cag ctg ggt ctc ttt 48 Val Leu Gly Gly Leu Leu Leu Leu Gly Val Ala Gln Leu Gly Leu Phe 1 5 10 15 ctg gag gaa aag ctg cgg gag cat ctg gca gag aag gag aag ctg aac 96 Leu Glu Glu Lys Leu Arg Glu His Leu Ala Glu Lys Glu Lys Leu Asn 20 25 30 gag gag agg cta gag caa gag gag aag ctc aaa gcc aaa atc agg caa 144 Glu Glu Arg Leu Glu Gln Glu Glu Lys Leu Lys Ala Lys Ile Arg Gln 35 40 45 ctg acg gaa gag aag gcg gct ttg gag gag tac att act caa gag aga 192 Leu Thr Glu Glu Lys Ala Ala Leu Glu Glu Tyr Ile Thr Gln Glu Arg 50 55 60 aac aga gcg aaa gag act tta gag gaa gaa cgg aag aga atg caa gaa 240 Asn Arg Ala Lys Glu Thr Leu Glu Glu Glu Arg Lys Arg Met Gln Glu 65 70 75 80 ctg gag agc ctc ctg gcc cag cag aag aag gct ttg gcg aaa agc att 288 Leu Glu Ser Leu Leu Ala Gln Gln Lys Lys Ala Leu Ala Lys Ser Ile 85 90 95 acc cag gag aag aac aga gtg aag gaa gca tta gag gaa gag cag aca 336 Thr Gln Glu Lys Asn Arg Val Lys Glu Ala Leu Glu Glu Glu Gln Thr 100 105 110 aga gtc caa gag ctg gag gaa cgc ttg gcc cgc cag aag gag atc tca 384 Arg Val Gln Glu Leu Glu Glu Arg Leu Ala Arg Gln Lys Glu Ile Ser 115 120 125 gag agc aac att gcg tac gag aaa cgc aaa gca aag gag gcc atg gag 432 Glu Ser Asn Ile Ala Tyr Glu Lys Arg Lys Ala Lys Glu Ala Met Glu 130 135 140 aag gaa aag aaa aag gtg caa gac ctg gag aat cgc tta acc aag cag 480 Lys Glu Lys Lys Lys Val Gln Asp Leu Glu Asn Arg Leu Thr Lys Gln 145 150 155 160 aaa gag gaa tta gaa tta aaa gag caa aaa gag gac gtt tta aat aat 528 Lys Glu Glu Leu Glu Leu Lys Glu Gln Lys Glu Asp Val Leu Asn Asn 165 170 175 aaa tta agt gac gca ctg gcc atg gtt gaa gag act cag aaa aca aag 576 Lys Leu Ser Asp Ala Leu Ala Met Val Glu Glu Thr Gln Lys Thr Lys 180 185 190 gca act gaa agt cta aaa gca gag agc ctc gcc ttg aaa tta aat gaa 624 Ala Thr Glu Ser Leu Lys Ala Glu Ser Leu Ala Leu Lys Leu Asn Glu 195 200 205 aca tta gcc gaa ctg gaa act acc aag aca aaa atg atc atg gtg gaa 672 Thr Leu Ala Glu Leu Glu Thr Thr Lys Thr Lys Met Ile Met Val Glu 210 215 220 gag cgg cta atc ctg cag cag aag atg gta aag gcc ctc cag gat gag 720 Glu Arg Leu Ile Leu Gln Gln Lys Met Val Lys Ala Leu Gln Asp Glu 225 230 235 240 cag gaa tca cag aga cac ggg ttt gga gaa gag atc atg gaa tat aag 768 Gln Glu Ser Gln Arg His Gly Phe Gly Glu Glu Ile Met Glu Tyr Lys 245 250 255 gag caa atc aaa cag cac gcc cag aca att gtg agc ctc gaa gag aaa 816 Glu Gln Ile Lys Gln His Ala Gln Thr Ile Val Ser Leu Glu Glu Lys 260 265 270 ctc cag aaa gtc act cag cac cat aaa aaa ata gaa ggc gag att gca 864 Leu Gln Lys Val Thr Gln His His Lys Lys Ile Glu Gly Glu Ile Ala 275 280 285 aca ttg aag gac aat gac cca gcc cca aag gag gaa agg ccg caa gac 912 Thr Leu Lys Asp Asn Asp Pro Ala Pro Lys Glu Glu Arg Pro Gln Asp 290 295 300 cct ctg gtg gct ccc atg aca gag agc agt gcc aaa gac atg gcg tac 960 Pro Leu Val Ala Pro Met Thr Glu Ser Ser Ala Lys Asp Met Ala Tyr 305 310 315 320 gaa cat ctg ata gat gac tta ttg gct gct cag aag gaa att ctg tct 1008 Glu His Leu Ile Asp Asp Leu Leu Ala Ala Gln Lys Glu Ile Leu Ser 325 330 335 cag cag gaa gtc atc atg aag tta agg aaa gac ctt acc gaa gcc cac 1056 Gln Gln Glu Val Ile Met Lys Leu Arg Lys Asp Leu Thr Glu Ala His 340 345 350 agc aga atg tcg gat ttg aga ggg gag cta aac gag aag cag aag atg 1104 Ser Arg Met Ser Asp Leu Arg Gly Glu Leu Asn Glu Lys Gln Lys Met 355 360 365 gaa ctg gag cag aac gtg gtg ctg gtc cag cag cag agc aag gag ctg 1152 Glu Leu Glu Gln Asn Val Val Leu Val Gln Gln Gln Ser Lys Glu Leu 370 375 380 agt gtg ctc aag gag aag atg gcc cag atg agc agc ctg gta gaa aag 1200 Ser Val Leu Lys Glu Lys Met Ala Gln Met Ser Ser Leu Val Glu Lys 385 390 395 400 aaa gat cgg gag ctg aag gcc ctt gag gag gca ctc agg gct tcc caa 1248 Lys Asp Arg Glu Leu Lys Ala Leu Glu Glu Ala Leu Arg Ala Ser Gln 405 410 415 gag aaa cac aga ctc cag ctg aac aca gag aag gaa cag aag ccc cgg 1296 Glu Lys His Arg Leu Gln Leu Asn Thr Glu Lys Glu Gln Lys Pro Arg 420 425 430 aag aag acc cag acg tgt gac acc tct gtg cag ata gaa ccc gtc cac 1344 Lys Lys Thr Gln Thr Cys Asp Thr Ser Val Gln Ile Glu Pro Val His 435 440 445 act gag gcc ttc tcc agc agc caa gag cag caa tcc ttc agc gat cta 1392 Thr Glu Ala Phe Ser Ser Ser Gln Glu Gln Gln Ser Phe Ser Asp Leu 450 455 460 ggg gtc agg tgc aaa ggg tcc cgg cac gag gag gtc att cag cgt cag 1440 Gly Val Arg Cys Lys Gly Ser Arg His Glu Glu Val Ile Gln Arg Gln 465 470 475 480 aaa aag gcc tta tct gaa ctt cga gcg cga att aaa gaa ctc gag aag 1488 Lys Lys Ala Leu Ser Glu Leu Arg Ala Arg Ile Lys Glu Leu Glu Lys 485 490 495 gcg cgc tca cca gat cat aaa gac cac cag aat gaa tca ttt cta gat 1536 Ala Arg Ser Pro Asp His Lys Asp His Gln Asn Glu Ser Phe Leu Asp 500 505 510 tta aag aac ctc aga atg gaa aac aat gtc cag aaa ata cta ctg gat 1584 Leu Lys Asn Leu Arg Met Glu Asn Asn Val Gln Lys Ile Leu Leu Asp 515 520 525 gca aaa ccg gat ttg cca act ctc tca aga ata gag atc cta gcg cct 1632 Ala Lys Pro Asp Leu Pro Thr Leu Ser Arg Ile Glu Ile Leu Ala Pro 530 535 540 cag aat ggc ctt tgc aac gca agg ttc ggc tca gcc atg gag aag tca 1680 Gln Asn Gly Leu Cys Asn Ala Arg Phe Gly Ser Ala Met Glu Lys Ser 545 550 555 560 ggg aag atg gat gtg gct gag gct tta gag ctc agt gaa aag ctg tac 1728 Gly Lys Met Asp Val Ala Glu Ala Leu Glu Leu Ser Glu Lys Leu Tyr 565 570 575 ctg gat atg agc aaa acc ctc gga agt ctc atg aac atc aag aat atg 1776 Leu Asp Met Ser Lys Thr Leu Gly Ser Leu Met Asn Ile Lys Asn Met 580 585 590 tca ggc cac gtg tcc atg aaa tac ctc tcc cgc cag gag agg gag aag 1824 Ser Gly His Val Ser Met Lys Tyr Leu Ser Arg Gln Glu Arg Glu Lys 595 600 605 gtc aac cag ctt cga caa agg gac ctc gac ctg gtg ttt gat aag atc 1872 Val Asn Gln Leu Arg Gln Arg Asp Leu Asp Leu Val Phe Asp Lys Ile 610 615 620 acc caa ctc aag aac cag ctg ggg agg aaa gag gag ctg ttg aga gga 1920 Thr Gln Leu Lys Asn Gln Leu Gly Arg Lys Glu Glu Leu Leu Arg Gly 625 630 635 640 tat gaa aag gac gtt gaa cag ctc agg cgg agc aaa gtg tcc att gag 1968 Tyr Glu Lys Asp Val Glu Gln Leu Arg Arg Ser Lys Val Ser Ile Glu 645 650 655 atg tac cag tcg cag gtg gca aag ctg gag gat gat atc tac aaa gag 2016 Met Tyr Gln Ser Gln Val Ala Lys Leu Glu Asp Asp Ile Tyr Lys Glu 660 665 670 gcc gaa gag aag gcc ctg ctg aag gag gcc ctg gag cgc atg gag cac 2064 Ala Glu Glu Lys Ala Leu Leu Lys Glu Ala Leu Glu Arg Met Glu His 675 680 685 cag ctg tgc cag gag aag agg atc aac agg gcc atc cgg cag cag aag 2112 Gln Leu Cys Gln Glu Lys Arg Ile Asn Arg Ala Ile Arg Gln Gln Lys 690 695 700 tagatgggag cttccagccc ctgcctcgca gacagatggt gaggatgaaa gaatgcaggc 2172 atccctcgct atctgctgtc cactctcgct gtcgtcatac ctcaggagcc aagtgctttt 2232 ggatggtgag ggtgcttgtc ccgtctctga agcacctgcc cagggcctgg caccagccgg 2292 cggacactgc cttccccatg ctgcccatga cccatgctgc ccgtgaccca tgcaggtggt 2352 ctcctgggtg agtcctgcct cagacccggt agggtctaca cactggaaag tttccccaaa 2412 gcaagtcaca catgagcagc acccgggcgg cttccaaagc tccctgaaag ctggcagagg 2472 ggctttcctg tctgctttgc agttgacata ttcatcatcc actcctgcag tccacaaggc 2532 actggaacag tgacctctaa atagagccag actctccctt tccttcactc ttgcctaagg 2592 tggagcagat cccaaggctg gggttaggca agtcagggaa agaaccacag tcactgtttc 2652 ttcatgaccg tctccaggcc agggactggg ctcacctgag ctttgcagcc gtgatagggc 2712 ttattaatgc ctctaatagc cctgcctggt acgatgatcc ctattttaca gatgaggaaa 2772 ctgcgcctca gagagttaag aggcgcccaa gtgcacacag cggctggtaa ggacagctgg 2832 gacctgaccc cagatccctc tgaccctggt tctcctgctg tctgcagggt tggccgtgag 2892 tcccctcctt gtaactgtca gcttttatgt gtgtgtgcat tctcgtgtgt gtgtacattc 2952 tcatgtgtgt gtgtgtgtgc acatgtgtac catgtgcatg agggtttggc tgtgtgtgac 3012 actatgtgtg tgtgtttgtg tgtgttgcct gcctgagctc agagagagcc aaacccccag 3072 agaagggtgc cccctccacc aaccaggtga gctccttgca gaggcctggc cttcatccca 3132 caaaccttgc agaccacagg ctccctggct tgcagccccc aaaaatgaag gcagcgctct 3192 gctctggacg tggcctttcc agcactcacc actctgaatt aaacatcaca ggcccccatc 3252 tgcacatgtc gtggggctgc ctcgggcaga ggaccgtttc cttttacgct gtgccatgcc 3312 agggagatct gggcagcagc agagtcctga gatgtccttt gatgtaccca caggagagtt 3372 cgctccttcc cgaggcagtg tcccccaggg cttggcaggc caggcccaca gcagagacac 3432 caaaccacag aatgggacgg cagagggccc taaaaagccc attgtcatgc actggctgaa 3492 aatgaaagaa aacctgcaga ttt 3515 <210> 32 <211> 2247 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3)..(2246) <400> 32 ag aag atg gat ttc aag tcc tca aag cag gcc gat tcc act tcc ata 47 Lys Met Asp Phe Lys Ser Ser Lys Gln Ala Asp Ser Thr Ser Ile 1 5 10 15 gga aag gag gat cct ggg tcc tca cgg aag gca gat ccc atg ttt aca 95 Gly Lys Glu Asp Pro Gly Ser Ser Arg Lys Ala Asp Pro Met Phe Thr 20 25 30 gga aag gca gag cct gaa atc ttg gga aag ggg gat cct gtg gct cct 143 Gly Lys Ala Glu Pro Glu Ile Leu Gly Lys Gly Asp Pro Val Ala Pro 35 40 45 gga agg atg gat ccc atg act gta aga aag gaa gat ctt gga tcc ctg 191 Gly Arg Met Asp Pro Met Thr Val Arg Lys Glu Asp Leu Gly Ser Leu 50 55 60 gga aaa gta gat cct ttg tgc tcc agc aag acg tat aca gtg tca ccg 239 Gly Lys Val Asp Pro Leu Cys Ser Ser Lys Thr Tyr Thr Val Ser Pro 65 70 75 agg aag gag gat cct ggg tct ttg aga aag gtg gat cct gtg tcc tca 287 Arg Lys Glu Asp Pro Gly Ser Leu Arg Lys Val Asp Pro Val Ser Ser 80 85 90 95 gac aaa gtg gac cct gta ttc cca aga aag gag gag ccc agg tat tca 335 Asp Lys Val Asp Pro Val Phe Pro Arg Lys Glu Glu Pro Arg Tyr Ser 100 105 110 gga aaa gag cat cct gtg tcc tca gaa aag gtc gct cct aca tct gca 383 Gly Lys Glu His Pro Val Ser Ser Glu Lys Val Ala Pro Thr Ser Ala 115 120 125 gaa aag gta gat ctt gta ttg tcg gga aag aga gat cct ggg ccc tcg 431 Glu Lys Val Asp Leu Val Leu Ser Gly Lys Arg Asp Pro Gly Pro Ser 130 135 140 gga aag gca gat ccc gtg ccc ttg gaa agc atg gat tct gcg tcc aca 479 Gly Lys Ala Asp Pro Val Pro Leu Glu Ser Met Asp Ser Ala Ser Thr 145 150 155 gga aag aca gag ccg ggg ctc ctg ggc aag ctg att cca ggc tca tca 527 Gly Lys Thr Glu Pro Gly Leu Leu Gly Lys Leu Ile Pro Gly Ser Ser 160 165 170 175 ggc aag aat ggg cct gta tcc tct ggg acc ggg gct cct ggg tcc ttg 575 Gly Lys Asn Gly Pro Val Ser Ser Gly Thr Gly Ala Pro Gly Ser Leu 180 185 190 gga agg ctg gat ccc aca tgc ttg ggg atg gca gat ccc gca tct gtg 623 Gly Arg Leu Asp Pro Thr Cys Leu Gly Met Ala Asp Pro Ala Ser Val 195 200 205 gga aat gta gaa act gtg cct gcc aca aaa gag gac tcc cgg ttc ctg 671 Gly Asn Val Glu Thr Val Pro Ala Thr Lys Glu Asp Ser Arg Phe Leu 210 215 220 gga aag atg gac cct gcc tcc tca gga gag ggg cgt cct gtg tct ggc 719 Gly Lys Met Asp Pro Ala Ser Ser Gly Glu Gly Arg Pro Val Ser Gly 225 230 235 cac acg gat act acg gct tca gca aag aca gat ctc aca tct ttg aaa 767 His Thr Asp Thr Thr Ala Ser Ala Lys Thr Asp Leu Thr Ser Leu Lys 240 245 250 255 aat gtg gat ccc atg tct tca ggc aag gtg gat cca gtt tct ctg gga 815 Asn Val Asp Pro Met Ser Ser Gly Lys Val Asp Pro Val Ser Leu Gly 260 265 270 aag atg gac ccc atg tgc tca gga aag cca gag ctc ttg tct cct gga 863 Lys Met Asp Pro Met Cys Ser Gly Lys Pro Glu Leu Leu Ser Pro Gly 275 280 285 cag gca gag cgt gtg tct gtg gga aag gca gga act gta tcc cca gga 911 Gln Ala Glu Arg Val Ser Val Gly Lys Ala Gly Thr Val Ser Pro Gly 290 295 300 aaa gag gac ccg gtg tcc tcc aga agg gag gac ccc ata tct gct gga 959 Lys Glu Asp Pro Val Ser Ser Arg Arg Glu Asp Pro Ile Ser Ala Gly 305 310 315 agt aga aag aca tca tct gaa aaa gtg aat cct gag tct tca gga aag 1007 Ser Arg Lys Thr Ser Ser Glu Lys Val Asn Pro Glu Ser Ser Gly Lys 320 325 330 335 aca aac cct gtg tct tca ggt cca ggc gat ccc agg tcc ttg ggg aca 1055 Thr Asn Pro Val Ser Ser Gly Pro Gly Asp Pro Arg Ser Leu Gly Thr 340 345 350 gca ggt ccc cca tct gca gta aag gct gag cca gcg acg ggg gga aaa 1103 Ala Gly Pro Pro Ser Ala Val Lys Ala Glu Pro Ala Thr Gly Gly Lys 355 360 365 gga gat ccc ctg tcc tcg gag aag gca ggt ctg gtg gcc tct gga aag 1151 Gly Asp Pro Leu Ser Ser Glu Lys Ala Gly Leu Val Ala Ser Gly Lys 370 375 380 gcg gct ccc aca gcc tca ggg aag gcc gag ccc ctc gcg gtg ggc aag 1199 Ala Ala Pro Thr Ala Ser Gly Lys Ala Glu Pro Leu Ala Val Gly Lys 385 390 395 gag gac cct gtg agc aag gga aag gca gac gct ggc ccc tct gga caa 1247 Glu Asp Pro Val Ser Lys Gly Lys Ala Asp Ala Gly Pro Ser Gly Gln 400 405 410 415 ggg gac tct gtg tct ata ggt aaa gtg gtc tca act cca gga aaa aca 1295 Gly Asp Ser Val Ser Ile Gly Lys Val Val Ser Thr Pro Gly Lys Thr 420 425 430 gtc ccg gtg ccc tcg ggg aag gtg gat ccc gtg tcc ctg gga aaa gca 1343 Val Pro Val Pro Ser Gly Lys Val Asp Pro Val Ser Leu Gly Lys Ala 435 440 445 gaa gct atc cca gag gga aaa gtg ggt tct ctg cct cta gag aag ggg 1391 Glu Ala Ile Pro Glu Gly Lys Val Gly Ser Leu Pro Leu Glu Lys Gly 450 455 460 agt cct gtt acc acc aca aag gcg gat ccc agg gcc tcg ggg aaa gca 1439 Ser Pro Val Thr Thr Thr Lys Ala Asp Pro Arg Ala Ser Gly Lys Ala 465 470 475 cag ccg cag tct ggt ggc aaa gca gaa aca aag ctc cct ggg caa gag 1487 Gln Pro Gln Ser Gly Gly Lys Ala Glu Thr Lys Leu Pro Gly Gln Glu 480 485 490 495 ggc gct gca gca cca gga gaa gca ggg gct gtg tgt ttg aaa aag gag 1535 Gly Ala Ala Ala Pro Gly Glu Ala Gly Ala Val Cys Leu Lys Lys Glu 500 505 510 aca cca cag gcc tca gag aag gtg gat cct gga tcc tgc aga aaa gca 1583 Thr Pro Gln Ala Ser Glu Lys Val Asp Pro Gly Ser Cys Arg Lys Ala 515 520 525 gag ccc ctt gcc tca ggg aag gga gag cct gtg tcc ctg ggg aaa gcc 1631 Glu Pro Leu Ala Ser Gly Lys Gly Glu Pro Val Ser Leu Gly Lys Ala 530 535 540 gac tct gca cct tcc aga aaa acg gag tcc cca tcc ttg ggg aag gtg 1679 Asp Ser Ala Pro Ser Arg Lys Thr Glu Ser Pro Ser Leu Gly Lys Val 545 550 555 gtc ccc ctg agt ctg gag aag acc aag ccg tcc tcc tcc tcc agg cag 1727 Val Pro Leu Ser Leu Glu Lys Thr Lys Pro Ser Ser Ser Ser Arg Gln 560 565 570 575 tta gac cgc aaa gcc ctc ggc tca gcc cgg tct ccc gag ggt gcc agg 1775 Leu Asp Arg Lys Ala Leu Gly Ser Ala Arg Ser Pro Glu Gly Ala Arg 580 585 590 ggc agt gaa ggc cgc gtg gag ccg aag gcc gag ccc gtg tcc agc acc 1823 Gly Ser Glu Gly Arg Val Glu Pro Lys Ala Glu Pro Val Ser Ser Thr 595 600 605 gag gcc tcc agt ctc ggc cag aaa gac ctg gaa gcc gct ggg gcc gag 1871 Glu Ala Ser Ser Leu Gly Gln Lys Asp Leu Glu Ala Ala Gly Ala Glu 610 615 620 aga agc ccc tgc cca gag gcc gca gcg ccc ccg ccg ggg ccg cgg act 1919 Arg Ser Pro Cys Pro Glu Ala Ala Ala Pro Pro Pro Gly Pro Arg Thr 625 630 635 cgc gac aac ttc acc aag gcg ccg tcg tgg gag gcg agc gcc ccg ccg 1967 Arg Asp Asn Phe Thr Lys Ala Pro Ser Trp Glu Ala Ser Ala Pro Pro 640 645 650 655 ccg ccg cgc gag gac gcg ggc act cag gcg ggc gcg cag gcc tgc gtc 2015 Pro Pro Arg Glu Asp Ala Gly Thr Gln Ala Gly Ala Gln Ala Cys Val 660 665 670 tca gtg gcc gtg agc ccc atg tct ccg cag gac ggc gct ggg ggc tcg 2063 Ser Val Ala Val Ser Pro Met Ser Pro Gln Asp Gly Ala Gly Gly Ser 675 680 685 gcc ttc agc ttc cag gcg gcg ccg cgc gcg ccc agc ccg ccc tcg cgc 2111 Ala Phe Ser Phe Gln Ala Ala Pro Arg Ala Pro Ser Pro Pro Ser Arg 690 695 700 cga gat gcg ggc ctg cag gtg tcg ctg ggc gcc gcc gag acg cgc tcc 2159 Arg Asp Ala Gly Leu Gln Val Ser Leu Gly Ala Ala Glu Thr Arg Ser 705 710 715 gtg gcc act ggg ccc atg aca cct caa gcc gcc gcg ccg ccc gcc ttc 2207 Val Ala Thr Gly Pro Met Thr Pro Gln Ala Ala Ala Pro Pro Ala Phe 720 725 730 735 ccc gaa gtg cgg gtg cgg ccc ggc tca gcg ctg gcg gcc g 2247 Pro Glu Val Arg Val Arg Pro Gly Ser Ala Leu Ala Ala 740 745 <210> 33 <211> 3512 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (818)..(2344) <400> 33 ccaaagatgg gttttgtctg cgggtgattt gggctctcga agtgcaactt tgtggccggg 60 acgcggatcg gccggcctgg gctcctgcag agcagatcct gtctgcgtcc tccaggagga 120 gtgggtggca ggactggggt ttcccacagg ttttggggcg gcggcgagat tggcacggtc 180 cggggtcgca ggcgcgcagc cacgcccctg gaagtccgcc ccggcccccg cccccaaccc 240 gcctcttcgg ggctttatgg cgtgaggttt ggggctggga tccatctgga gccgagcaga 300 aaacttttcc cctcccgttc ccggtccctt ttgtctttct tggacgcggt ggcggcgccg 360 cctgagcggc gactccctct cccctgcccg gcttgctgcg cccggtgccc tccgagggca 420 ggcgcgcctg gactctgcgc ccggatggcg gcggccctct gtgagcaccg gcagcggcgc 480 atcccctgcc ccgaggcctc cggtgccccc ccggcgcggg cataggggcg cccccaccct 540 ccgtccgctt gcaccccttg ccacccgccc cctcgcctga ctcatccgcc cgcggtggcc 600 gcccgagccc tgggatgggg agggagaccg cggctgcccg cggcggccga gattcccgct 660 gacgcccccg accctgccgc cttcttcgtc cgcctccaga ggcgcccgac gtcccgacag 720 ctcctggagt gagaccagga ctgagaacag ggagaggcga cccgaccccc agggcccggt 780 gctcaggaca gcacacagag ccgctgaaaa cgactga aga gag caa ggg att tcc 835 Arg Glu Gln Gly Ile Ser 1 5 tgg gac atc tgg ctc tgg aga gta aaa ggc caa gct atg ata gca act 883 Trp Asp Ile Trp Leu Trp Arg Val Lys Gly Gln Ala Met Ile Ala Thr 10 15 20 ggt gga gtg ata act ggc ctg gcc gcc ttg aaa agg caa gac tct gcc 931 Gly Gly Val Ile Thr Gly Leu Ala Ala Leu Lys Arg Gln Asp Ser Ala 25 30 35 aga tca cag cag cat gtc aac ctc agc ccg tct cct gct acc caa gag 979 Arg Ser Gln Gln His Val Asn Leu Ser Pro Ser Pro Ala Thr Gln Glu 40 45 50 aag aag ccc atc agg cgc cgg ccc cgg gca gat gtt gtg gtt gtt cgt 1027 Lys Lys Pro Ile Arg Arg Arg Pro Arg Ala Asp Val Val Val Val Arg 55 60 65 70 ggc aaa atc cgg ctt tat tcc cca tct ggt ttt ttt ctt att tta gga 1075 Gly Lys Ile Arg Leu Tyr Ser Pro Ser Gly Phe Phe Leu Ile Leu Gly 75 80 85 gtg ctc atc tcc att ata gga att gct atg gcc gtt ctt gga tat tgg 1123 Val Leu Ile Ser Ile Ile Gly Ile Ala Met Ala Val Leu Gly Tyr Trp 90 95 100 ccc caa aaa gaa cat ttt att gat gct gaa aca aca ctg tca aca aat 1171 Pro Gln Lys Glu His Phe Ile Asp Ala Glu Thr Thr Leu Ser Thr Asn 105 110 115 gaa act cag gtc att cgg aat gaa ggc ggt gtg gtg gtt cgc ttc ttt 1219 Glu Thr Gln Val Ile Arg Asn Glu Gly Gly Val Val Val Arg Phe Phe 120 125 130 gag cag cat ttg cat tct gat aag atg aaa atg ctt ggc cca ttc acc 1267 Glu Gln His Leu His Ser Asp Lys Met Lys Met Leu Gly Pro Phe Thr 135 140 145 150 atg ggg att ggc att ttc att ttc att tgt gct aat gcc att ctt cat 1315 Met Gly Ile Gly Ile Phe Ile Phe Ile Cys Ala Asn Ala Ile Leu His 155 160 165 gaa aac cgt gac aaa gag acc aaa atc ata cac atg agg gat atc tat 1363 Glu Asn Arg Asp Lys Glu Thr Lys Ile Ile His Met Arg Asp Ile Tyr 170 175 180 tcc aca gtc att gac att cac acg cta aga atc aag gag caa agg caa 1411 Ser Thr Val Ile Asp Ile His Thr Leu Arg Ile Lys Glu Gln Arg Gln 185 190 195 atg aac ggc atg tac act ggt ttg atg gga gaa aca gaa gta aaa cag 1459 Met Asn Gly Met Tyr Thr Gly Leu Met Gly Glu Thr Glu Val Lys Gln 200 205 210 aat ggg agc tcc tgt gcc tcg aga ttg gca gca aat acg atc gcc tct 1507 Asn Gly Ser Ser Cys Ala Ser Arg Leu Ala Ala Asn Thr Ile Ala Ser 215 220 225 230 ttc tcg ggt ttt cgg agc agt ttt cga atg gac agc tcc gtg gag gag 1555 Phe Ser Gly Phe Arg Ser Ser Phe Arg Met Asp Ser Ser Val Glu Glu 235 240 245 gat gaa ctt atg tta aat gaa ggt aag agt tct ggg cat ctt atg ccc 1603 Asp Glu Leu Met Leu Asn Glu Gly Lys Ser Ser Gly His Leu Met Pro 250 255 260 cct ttg ctc tct gac agc tct gtg tct gtc ttt ggc ctc tat cca cct 1651 Pro Leu Leu Ser Asp Ser Ser Val Ser Val Phe Gly Leu Tyr Pro Pro 265 270 275 cct tcc aag aca act gat gat aag acc agc ggc tct aag aaa tgt gaa 1699 Pro Ser Lys Thr Thr Asp Asp Lys Thr Ser Gly Ser Lys Lys Cys Glu 280 285 290 acc aag tca att gtg tca tcg tcc atc agt gct ttt aca ttg cct gtg 1747 Thr Lys Ser Ile Val Ser Ser Ser Ile Ser Ala Phe Thr Leu Pro Val 295 300 305 310 atc aaa ctt aat aac tgt gtt att gat gag ccc agt ata gat aac atc 1795 Ile Lys Leu Asn Asn Cys Val Ile Asp Glu Pro Ser Ile Asp Asn Ile 315 320 325 act gaa gat gct gac aac ctc aaa agt agg tca agg aat ttg tca atg 1843 Thr Glu Asp Ala Asp Asn Leu Lys Ser Arg Ser Arg Asn Leu Ser Met 330 335 340 gat tcc ctt gtg gtt cct ttg ccc aac acc agt gaa tcc ttc cag ccc 1891 Asp Ser Leu Val Val Pro Leu Pro Asn Thr Ser Glu Ser Phe Gln Pro 345 350 355 gtc agc aca gtg cta cca agg aat aat tcc att ggg gag tcg ttg tcg 1939 Val Ser Thr Val Leu Pro Arg Asn Asn Ser Ile Gly Glu Ser Leu Ser 360 365 370 agt cag tac aag tca tct atg gct ctc gga cct ggg gct gga cag ctc 1987 Ser Gln Tyr Lys Ser Ser Met Ala Leu Gly Pro Gly Ala Gly Gln Leu 375 380 385 390 ttg tct cct ggg gct gcc aga aga cag ttt ggg tcc aat aca tcc ttg 2035 Leu Ser Pro Gly Ala Ala Arg Arg Gln Phe Gly Ser Asn Thr Ser Leu 395 400 405 cat ttg ctc tcg tca cac tca aag tcc ttg gac tta gac cgg ggt ccc 2083 His Leu Leu Ser Ser His Ser Lys Ser Leu Asp Leu Asp Arg Gly Pro 410 415 420 tcc act cta act gtt cag gca gaa caa cgg aaa cat cca agt tgg cct 2131 Ser Thr Leu Thr Val Gln Ala Glu Gln Arg Lys His Pro Ser Trp Pro 425 430 435 agg ttg gat cgg aac aac agc aag gga tat atg aaa cta gag aac aaa 2179 Arg Leu Asp Arg Asn Asn Ser Lys Gly Tyr Met Lys Leu Glu Asn Lys 440 445 450 gaa gac ccg atg gat agg ttg ctt gtg ccc caa gtt gcc atc aaa aag 2227 Glu Asp Pro Met Asp Arg Leu Leu Val Pro Gln Val Ala Ile Lys Lys 455 460 465 470 gac ttt acc aat aag gag aag ctt ctt atg att tca aga tct cac aat 2275 Asp Phe Thr Asn Lys Glu Lys Leu Leu Met Ile Ser Arg Ser His Asn 475 480 485 aat ttg agt ttt gaa cat gat gag ttt ttg agt aac aac cta aag agg 2323 Asn Leu Ser Phe Glu His Asp Glu Phe Leu Ser Asn Asn Leu Lys Arg 490 495 500 gga act tct gaa aca agg ttt taatgttaaa agaatatatc attttacaag 2374 Gly Thr Ser Glu Thr Arg Phe 505 ggtatatatt ttaaaacgat tttcactggt gtttccttct taaagtattg gctgtaagcc 2434 tttttaatca aatggtttgt agtgtattag aattggctgc ttagttctgt aatgaagatg 2494 gttgtatgtt tgggttactt gtgactgcag tactctatgt taccacacat gattttattt 2554 ttctcttcct ttgaaagcat gatctctttt attaatatga atgcaaaatg cttgcatcca 2614 aattaaagct tattttcttt acttttaagt tctttgattg ccctattcat aaaatgaaat 2674 gtccagtatg gaaaacatag ggtaccaaag tgtggaccag gagtacaaat tcagtcccaa 2734 tactcaatac gtattataga tgactatgag tgcaaacctt aggatgtgat tttctgaata 2794 attgttcttt gtaggatttg gttacattat ttaaaatgaa aaagatctag ttttagtgtg 2854 agctcagtaa tgttaattgg ttaagttcat tgtgaatctt gagttttaga taagtagtta 2914 tttttttcaa tatcacttct gtttttagtg atattatatc aagaaacaac gtattcaaga 2974 gccatggctg acagtgccag atatacttag ggataaacat caaaatgcaa ttatagttgc 3034 tataacgtta gatactcgga atcaaaattt atttgcaagc tgacttgata aactaaatga 3094 accaataaaa tttgtagaaa tgctatcctg aaataattat atacatgaag acaatgttga 3154 ctaatgaatt aagatacatt atatactagt taatgctaac tagtctcagt acctgttttt 3214 agccatctgt tactgtccaa tagcacctca ttcccacatt ctattttccc ccggtattct 3274 ttagatccta gtatttggaa aacaatcggc taaccttgac atttcttttt accttcatat 3334 gccactatct cggtagttca aaaaaattta gttcttgata aattgccttg aagtttacct 3394 tgtgctggag agccttatga taactccaaa gactttctta cggtataata catgttgttt 3454 aggattgtgt ttcttagtca ctgaagataa taaatattaa aatggatgtt ttcatcag 3512 <210> 34 <211> 3700 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (224)..(1603) <400> 34 ctgggtctcc agcacaccct ggagaaaagc aggtcagggg gtggtgcttc tgtttccaga 60 tgagcaaact agggctgagg gagagggcgt tctctggtca gggtggtaga gccagtctcg 120 tggaagccgg ctgagccact gaaacagaat cagttttctc atggaccaaa cggggatagt 180 gtctggcctg cgccacccca agtgtattgt gaagatgaaa tga gaa ggg gtt ttt 235 Glu Gly Val Phe 1 tgt tgt ggt tgc tgg aag gag atc cta gaa ggg agg aat ggg gga gaa 283 Cys Cys Gly Cys Trp Lys Glu Ile Leu Glu Gly Arg Asn Gly Gly Glu 5 10 15 20 gat ggc aaa ggg atc cta gga cga ggc gta tgg gca agg gaa gct tgt 331 Asp Gly Lys Gly Ile Leu Gly Arg Gly Val Trp Ala Arg Glu Ala Cys 25 30 35 ctt tct ggg agg aaa atc tcg aac caa gaa ttt cag gaa gaa ggc act 379 Leu Ser Gly Arg Lys Ile Ser Asn Gln Glu Phe Gln Glu Glu Gly Thr 40 45 50 ggg aaa aga ggg agg agg tgc cct cag atc cat gga ggt gag tgt cag 427 Gly Lys Arg Gly Arg Arg Cys Pro Gln Ile His Gly Gly Glu Cys Gln 55 60 65 ccc cca gat ctc ttg tgt ggc cac cac ttt cac ggc aac cac tcc tca 475 Pro Pro Asp Leu Leu Cys Gly His His Phe His Gly Asn His Ser Ser 70 75 80 ctg gga atc ctt gga gtc tgg tgc ttt cac cac cct gcc ccg gct gct 523 Leu Gly Ile Leu Gly Val Trp Cys Phe His His Pro Ala Pro Ala Ala 85 90 95 100 tca tgt gtg cca cct cgc cct gtt tcc aga ctg atg cag aga aag ttc 571 Ser Cys Val Pro Pro Arg Pro Val Ser Arg Leu Met Gln Arg Lys Phe 105 110 115 tca gag ccc aac act tac atc gat ggc ctg cct agc cag gac cgc cag 619 Ser Glu Pro Asn Thr Tyr Ile Asp Gly Leu Pro Ser Gln Asp Arg Gln 120 125 130 gag gag ctg tat gac gac gtg gac ctg tca gag ctc aca gct gcg gtg 667 Glu Glu Leu Tyr Asp Asp Val Asp Leu Ser Glu Leu Thr Ala Ala Val 135 140 145 gag cct acc gag gaa gcc acc cct gtt gca gat gac cca aat gag aga 715 Glu Pro Thr Glu Glu Ala Thr Pro Val Ala Asp Asp Pro Asn Glu Arg 150 155 160 gaa tct gac cga gtg tac ctg gac ctc aca cct gtc aag tcc ttt ctg 763 Glu Ser Asp Arg Val Tyr Leu Asp Leu Thr Pro Val Lys Ser Phe Leu 165 170 175 180 cat ggc ccc agc agt gca cag gcc cag gcc tcc tcc ccg acg ttg tcc 811 His Gly Pro Ser Ser Ala Gln Ala Gln Ala Ser Ser Pro Thr Leu Ser 185 190 195 tgc ctg gac aat gca act gag gcc ctc ccg gca gac tca ggc cca ggt 859 Cys Leu Asp Asn Ala Thr Glu Ala Leu Pro Ala Asp Ser Gly Pro Gly 200 205 210 ccc acc cca gat gag ccc tgc ata aag tgt cca gag aac ctg gga gaa 907 Pro Thr Pro Asp Glu Pro Cys Ile Lys Cys Pro Glu Asn Leu Gly Glu 215 220 225 cag cag ctg gag agt ttg gag cca gag gat cct tcc ctg aga atc acc 955 Gln Gln Leu Glu Ser Leu Glu Pro Glu Asp Pro Ser Leu Arg Ile Thr 230 235 240 acc gtc aaa atc cag acg gaa cag cag aga atc tcc ttc cca ccg agc 1003 Thr Val Lys Ile Gln Thr Glu Gln Gln Arg Ile Ser Phe Pro Pro Ser 245 250 255 260 tgc ccg gat gcc gtg gtg gcc acc cca cct ggt gcc agc cca cct gtg 1051 Cys Pro Asp Ala Val Val Ala Thr Pro Pro Gly Ala Ser Pro Pro Val 265 270 275 aag gac agg ttg cgc gtg acc agt gca gag atc aag ctt ggc aag aat 1099 Lys Asp Arg Leu Arg Val Thr Ser Ala Glu Ile Lys Leu Gly Lys Asn 280 285 290 cgg aca gaa gct gag gtg aag cgg tac aca gag gag aag gag agg ctt 1147 Arg Thr Glu Ala Glu Val Lys Arg Tyr Thr Glu Glu Lys Glu Arg Leu 295 300 305 gaa aag aag aag gaa gaa atc cgg ggg cac ctg gct cag ctc cgg aaa 1195 Glu Lys Lys Lys Glu Glu Ile Arg Gly His Leu Ala Gln Leu Arg Lys 310 315 320 gag aaa cgg gag cta aag gaa acc cta ctg aaa tgc aca gac aag gaa 1243 Glu Lys Arg Glu Leu Lys Glu Thr Leu Leu Lys Cys Thr Asp Lys Glu 325 330 335 340 gtc ctg gcg agc ctg gag cag aag ctg aag gaa att gac gag gag tgc 1291 Val Leu Ala Ser Leu Glu Gln Lys Leu Lys Glu Ile Asp Glu Glu Cys 345 350 355 cgg ggc gag gag agc agg cgc gtg gac ctg gag ctc agc atc atg gag 1339 Arg Gly Glu Glu Ser Arg Arg Val Asp Leu Glu Leu Ser Ile Met Glu 360 365 370 gtg aag gac aac ctg aag aag gct gag gca ggg cct gtg acg tta ggc 1387 Val Lys Asp Asn Leu Lys Lys Ala Glu Ala Gly Pro Val Thr Leu Gly 375 380 385 acc acc gtg gac acc acc cac ctg gag aat gtg agc ccc cgc ccc aaa 1435 Thr Thr Val Asp Thr Thr His Leu Glu Asn Val Ser Pro Arg Pro Lys 390 395 400 gct gtc aca cct gcc tct gcc cca gac tgt acc cca gtc aac tct gca 1483 Ala Val Thr Pro Ala Ser Ala Pro Asp Cys Thr Pro Val Asn Ser Ala 405 410 415 420 acc aca ctc aag aac agg cct ctc tcg gtc gtg gtc aca ggc aaa ggc 1531 Thr Thr Leu Lys Asn Arg Pro Leu Ser Val Val Val Thr Gly Lys Gly 425 430 435 act gta ctc cag aaa gcc aag gta agc agt cac tcc cag cct ccc ttg 1579 Thr Val Leu Gln Lys Ala Lys Val Ser Ser His Ser Gln Pro Pro Leu 440 445 450 ggg cca gca gaa atg tca cta agg taggggacca tcttctgacc caggtggtgc 1633 Gly Pro Ala Glu Met Ser Leu Arg 455 460 tttgtggctt ttggcaccag ctctgagcaa gggctcggca ctcaccaagg agtggccatg 1693 gctttgccat gccttcagct cagtctctgg cactgaccaa ccagaaaggt gtctgcactt 1753 ggttcgagca tccttccctg tgagcttggg gatgcttcag ttcttgccct ccacacagct 1813 atgggtagat tccaggaggc cagctgcagc tcagggacag attatgactg agttttcaaa 1873 ccaaaaagtc agtcagtgac tccacaggac ttctaccatt aaaactaaag aaacagactc 1933 acataggtgg tttgaattgc ccaaagttgc ccacccaact actggcaaaa ttctcagcaa 1993 gttgtgaatg aggaatccat gctatgatgc ggtttctccc tgatggctag tcaaaaaagt 2053 atcattaatc atttactcat ttactcattt gtacactaaa gaacatgcct agggctgcct 2113 ttgcttttgg caaattctgc tccttattcc tatcctcctt acctgctgga gatatttgga 2173 ggtcccacaa caatggctaa ccaataaatc catgcaagca tctgaacctc cactcccttg 2233 ttgctgtgag agacatcact tataggcact cgctgttgtg ccacagtctc aaaatctctg 2293 aataggcact ctaagcagtg atgaacacac agggtttgaa acatttatca cctctgtgcc 2353 taaaatagtt tttctcacat tttttctatg tatatcaagg ttgctacagt ggataactaa 2413 ctatcttttt ggtggggggt gggtgctggt atttgaatgg taccctagga atgggagaag 2473 aaaggagcaa gttagaaaac aagcttcatc taaagactct catgtcaatg tggaccttgg 2533 tgacaatcct gctttgttaa agcaaaaact atgcgaaagg gtgagtctgt ttagaagaaa 2593 aagcaaagac tgaggtactg tgaatggaga gcttcagcta agaggaggct ctgtcccttt 2653 tcagagccaa aggaaataat acaacaaaaa ggaggcttct ttggagacct aagtctattg 2713 gatgtaaaca agacgttgta tttagggatg ttctgtgttt ctttcttttt tgaagttgtc 2773 atcaattgct ttactaagat ttttaaatag tgaaaacctc ctgtttagac tttggtggaa 2833 gatgaatcaa ggaagcaggg ccctgtctta tgggtcacgt gtctttggtg agtgagaaga 2893 cctaaactcc tggccatcat ctcttatcca atacttagca gttggggatt aaaccatcct 2953 tgccttcagt tctctccaat attaccaggc ccaactcagt cttcagtgat tttaaacagc 3013 attgacatca tctgtaaaac catcatctgt aaaaccatct atgacatgag ttttgagaaa 3073 caataatggg gaaaatattt gggaccaagc tgaagcacta atcccactaa gttaaagact 3133 tctttccagt ccaaggcagg cctgaatcaa ctgtctttaa ataaaatttt aagtgatgct 3193 gtattatata taggaaaaaa tgcttaaaat cctgtcattt agaacagtga aaagtatctt 3253 ttgagattaa agtgactctt tactgtagga aaaatattac tctgtgttta cagattcatt 3313 gctgtggtca ggccattttt aagggaagag ttatttaata taaatagtct ctgattttaa 3373 gttctgttta atgttcattc tccttccaag aacaaagtgg tgatttttgg ttagggtgat 3433 cgccctctta aaattggcag tgctgttcct tgtgctgccc ctgtcttttc ctctgatggc 3493 attttttttt ttttttaaca caggttgaaa catttcatct attatctctg cctcatttct 3553 ggagggttgt gtatcagttc tctaacactt gttcctgaga actaaatgtc ttttttattc 3613 ttatttcctc tctcataaac atttggtgac cttttaccaa gtggtgagtt agttaggttt 3673 tttaaaataa aatgttcatt gtatttg 3700 <210> 35 <211> 3712 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (407)..(1909) <400> 35 gcgaggacag ctgaataact gggagctcga agttgcttgc tgcctccggg agtggtctgc 60 ttggctgtcg cgttttcctt ttcttttttt tttaaaaaaa aaaaagccaa acgtttgctc 120 accatcacct gcagaagtga gtttttattg aagaagctcc agctgctttc tccttattgc 180 cggcagcctg gcaagcctcc cttagagtga gctacttctc aggccgggca cgacagcagt 240 gctagcacat ttgaaaaagc aggaaaccgc ccctgcatgc agagcttcca gcctgagaac 300 cccaggccag tcctcccagc agctgtgtag ccagagagcc ttggtactgt ggtcacatcc 360 ctcaaaagtg aacagtcgcc atcggaggcg tttggaggag accgtg atg ttg cag 415 Met Leu Gln 1 atg ctg tgg cat ttc cta gct agc ttt ttc ccc agg gct ggg tgc cac 463 Met Leu Trp His Phe Leu Ala Ser Phe Phe Pro Arg Ala Gly Cys His 5 10 15 ggc tcc aga gag ggg gac gat cgt gaa gtc aga ggc acc cca gcc cct 511 Gly Ser Arg Glu Gly Asp Asp Arg Glu Val Arg Gly Thr Pro Ala Pro 20 25 30 35 gcc tgg aga gac cag atg gca agc ttt ttg ggg aaa cag gac gga agg 559 Ala Trp Arg Asp Gln Met Ala Ser Phe Leu Gly Lys Gln Asp Gly Arg 40 45 50 gct gag gcc acg gaa aaa aga ccc acc att ttg ctg gtg gtt gga cct 607 Ala Glu Ala Thr Glu Lys Arg Pro Thr Ile Leu Leu Val Val Gly Pro 55 60 65 gca gag cag ttt cct aag aaa att gta caa gct gga gat aag gac ctt 655 Ala Glu Gln Phe Pro Lys Lys Ile Val Gln Ala Gly Asp Lys Asp Leu 70 75 80 gat ggg cag cta gac ttt gaa gaa ttt gtc cat tat ctc caa gat cat 703 Asp Gly Gln Leu Asp Phe Glu Glu Phe Val His Tyr Leu Gln Asp His 85 90 95 gag aag aag ctg agg ctg gtg ttt aag agt ttg gac aaa aag aat gat 751 Glu Lys Lys Leu Arg Leu Val Phe Lys Ser Leu Asp Lys Lys Asn Asp 100 105 110 115 gga cgc att gac gcg cag gag atc atg cag tcc ctg cgg gac ttg gga 799 Gly Arg Ile Asp Ala Gln Glu Ile Met Gln Ser Leu Arg Asp Leu Gly 120 125 130 gtc aag ata tct gaa cag cag gca gaa aaa att ctc aag aga ata cga 847 Val Lys Ile Ser Glu Gln Gln Ala Glu Lys Ile Leu Lys Arg Ile Arg 135 140 145 acg ggc cat ttc tgg ggc cct gtc acc tac atg gat aaa aac ggc acg 895 Thr Gly His Phe Trp Gly Pro Val Thr Tyr Met Asp Lys Asn Gly Thr 150 155 160 atg acc atc gac tgg aac gag tgg aga gac tac cac ctc ctc cac ccc 943 Met Thr Ile Asp Trp Asn Glu Trp Arg Asp Tyr His Leu Leu His Pro 165 170 175 gtg gaa aac atc ccc gag atc atc ctc tac tgg aag cat tcc acg atc 991 Val Glu Asn Ile Pro Glu Ile Ile Leu Tyr Trp Lys His Ser Thr Ile 180 185 190 195 ttt gat gtg ggt gag aat cta acg gtc ccg gat gag ttc aca gtg gag 1039 Phe Asp Val Gly Glu Asn Leu Thr Val Pro Asp Glu Phe Thr Val Glu 200 205 210 gag agg cag acg ggg atg tgg tgg aga cac ctg gtg gca gga ggt ggg 1087 Glu Arg Gln Thr Gly Met Trp Trp Arg His Leu Val Ala Gly Gly Gly 215 220 225 gca ggg gcc gta tcc aga acc tgc acg gcc ccc ctg gac agg ctc aag 1135 Ala Gly Ala Val Ser Arg Thr Cys Thr Ala Pro Leu Asp Arg Leu Lys 230 235 240 gtg ctc atg cag gtc cat gcc tcc cgc agc aac aac atg ggc atc gtt 1183 Val Leu Met Gln Val His Ala Ser Arg Ser Asn Asn Met Gly Ile Val 245 250 255 ggt ggc ttc act cag atg att cga gaa gga ggg gcc agg tca ctc tgg 1231 Gly Gly Phe Thr Gln Met Ile Arg Glu Gly Gly Ala Arg Ser Leu Trp 260 265 270 275 cgg ggc aat ggc atc aac gtc ctc aaa att gcc ccc gaa tca gcc atc 1279 Arg Gly Asn Gly Ile Asn Val Leu Lys Ile Ala Pro Glu Ser Ala Ile 280 285 290 aaa ttc atg gcc tat gag cag atc aag cgc ctt gtt ggt agt gac cag 1327 Lys Phe Met Ala Tyr Glu Gln Ile Lys Arg Leu Val Gly Ser Asp Gln 295 300 305 gag act ctg agg att cac gag agg ctt gtg gca ggg tcc ttg gca ggg 1375 Glu Thr Leu Arg Ile His Glu Arg Leu Val Ala Gly Ser Leu Ala Gly 310 315 320 gcc atc gcc cag agc agc atc tac cca atg gag gtc ctg aag acc cgg 1423 Ala Ile Ala Gln Ser Ser Ile Tyr Pro Met Glu Val Leu Lys Thr Arg 325 330 335 atg gcg ctg cgg aag aca ggc cag tac tca gga atg ctg gac tgc gcc 1471 Met Ala Leu Arg Lys Thr Gly Gln Tyr Ser Gly Met Leu Asp Cys Ala 340 345 350 355 agg agg atc ctg gcc aga gag ggg gtg gcc gcc ttc tac aaa ggc tat 1519 Arg Arg Ile Leu Ala Arg Glu Gly Val Ala Ala Phe Tyr Lys Gly Tyr 360 365 370 gtc ccc aac atg ctg ggc atc atc ccc tat gcc ggc atc gac ctt gca 1567 Val Pro Asn Met Leu Gly Ile Ile Pro Tyr Ala Gly Ile Asp Leu Ala 375 380 385 gtc tac gag acg ctc aag aat gcc tgg ctg cag cac tat gca gtg aac 1615 Val Tyr Glu Thr Leu Lys Asn Ala Trp Leu Gln His Tyr Ala Val Asn 390 395 400 agc gcg gac ccc ggc gtg ttt gtg ctc ctg gcc tgt ggc acc atg tcc 1663 Ser Ala Asp Pro Gly Val Phe Val Leu Leu Ala Cys Gly Thr Met Ser 405 410 415 agt acc tgt ggc cag ctg gcc agc tac ccc ctg gcc cta gtc agg acc 1711 Ser Thr Cys Gly Gln Leu Ala Ser Tyr Pro Leu Ala Leu Val Arg Thr 420 425 430 435 cgg atg cag gcg caa gcc tct att gag ggc gct ccg gag gtg acc atg 1759 Arg Met Gln Ala Gln Ala Ser Ile Glu Gly Ala Pro Glu Val Thr Met 440 445 450 agc agc ctc ttc aaa cat atc ctg cgg acc gag ggg gcc ttc ggg ctg 1807 Ser Ser Leu Phe Lys His Ile Leu Arg Thr Glu Gly Ala Phe Gly Leu 455 460 465 tac agg ggg ctg gcc ccc aac ttc atg aag gtc atc cca gct gtg agc 1855 Tyr Arg Gly Leu Ala Pro Asn Phe Met Lys Val Ile Pro Ala Val Ser 470 475 480 atc agc tac gtg gtc tac gag aac ctg aag atc acc ctg ggc gtg cag 1903 Ile Ser Tyr Val Val Tyr Glu Asn Leu Lys Ile Thr Leu Gly Val Gln 485 490 495 tcg cgg tgacgggggg agggccgccc ggcagtggac tcgctgatcc tgggccgcag 1959 Ser Arg 500 cctggggtgt gcagccatct cattctgtga atgtgccaac actaagctgt ctcgagccaa 2019 gctgtgaaaa ccctagacgc acccgcaggg agggtgggga gagctggcag gcccagggct 2079 tgtcctgctg accccagcag accctcctgt tggttccagc gaagaccaca ggcattcctt 2139 agggtccagg gtcagcaggc tccgggctca catgtgtaag gacaggacat tttctgcagt 2199 gcctgccaat agtgagcttg gagcctggag gccggcttag ttcttccatt tcacccttgc 2259 agccagctgt tggccacggc ccctgccctc tggtctgccg tgcatctccc tgtgccctct 2319 tgctgcctgc ctgtctgctg aggtaaggtg ggaggagggc tacagcccac atcccacccc 2379 ctcgtccaat cccataatcc atgatgaaag gtgaggtcac gtggcctccc aggcctgact 2439 tcccaaccta cagcattgac gccaacttgg ctgtgaagga agaggaaagg atctggcctt 2499 gtggtcactg gcatctgagc cctgctgatg gctggggctc tcgggcatgc ttgggagtgc 2559 agggggctcg ggctgcctgg cctggctgca cagaaggcaa gtgctggggc tcatggtgct 2619 ctgagctggc ctggaccctg tcaggatggg ccccacctca gaaccaaact cactgtcccc 2679 actgtggcat gagggcagtg gagcaccatg tttgagggcg aagggcagag cgtttgtgtg 2739 ttctggggag ggaaggaaaa ggtgttggag gccttaatta tggactgttg ggaaaagggt 2799 tttgtccaga aggacaagcc ggacaaatga gcgacttctg tgcttccaga ggaagacgag 2859 ggagcaggag cttggctgac tgctcagagt ctgttctgac gccctggggg ttcctgtcca 2919 accccagcag gggcgcagcg ggaccagccc cacattccac ttgtgtcact gcttggaacc 2979 tatttatttt gtatttattt gaacagagtt atgtcctaac tatttttata gatttgttta 3039 attaatagct tgtcattttc aagttcattt tttattcata tttatgttca tggttgattg 3099 taccttccca agcccgccca gtgggatggg aggaggagga gaaggggggc cttgggccgc 3159 tgcagtcaca tctgtccaga gaaattcctt ttgggactgg aggcagaaaa gcggccagaa 3219 ggcagcagcc ctggctcctt tcctttggca ggttggggaa gggcttgccc ccagccttag 3279 gatttcaggg tttgactggg ggcgtggaga gagagggagg aacctcaata accttgaagg 3339 tggaatccag ttatttcctg cgctgcgagg gtttctttat ttcactcttt tctgaatgtc 3399 aaggcagtga ggtgcctctc actgtgaatt tgtggtgggc gggggctgga ggagagggtg 3459 gggggctggc tccgtccctc ccagccttct gctgcccttg cttaacaatg ccggccaact 3519 ggcgacctca cggttgcact tccattccac cagaatgacc tgatgaggaa atcttcaata 3579 ggatgcaaag atcaatgcaa aaattgttat atatgaacat ataactggag tcgtcaaaaa 3639 gcaaattaag aaagaattgg acgttagaag ttgtcattta aagcagcctt ctaataaagt 3699 tgtttcaaag ctg 3712 <210> 36 <211> 3299 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (3)..(3041) <400> 36 tt cag ttt ctc ttc gat gtg ctg cag aaa aca ctt tca ctc aag ctg 47 Gln Phe Leu Phe Asp Val Leu Gln Lys Thr Leu Ser Leu Lys Leu 1 5 10 15 gtc cat gtt gct ggt cct ggc ccc aca ggg ccc atc aag att ttc ccc 95 Val His Val Ala Gly Pro Gly Pro Thr Gly Pro Ile Lys Ile Phe Pro 20 25 30 ttc aaa tcc ctt cgg cac ctg gag ctc cga ggt gtt ccc ctc cac tgt 143 Phe Lys Ser Leu Arg His Leu Glu Leu Arg Gly Val Pro Leu His Cys 35 40 45 ctg cat ggc ctc cga ggc atc tac tcc cag ctg gag acc ctg att tgc 191 Leu His Gly Leu Arg Gly Ile Tyr Ser Gln Leu Glu Thr Leu Ile Cys 50 55 60 agc agg agc ctc cag gca tta gag gag ctc ctc tca gcc tgc ggc ggc 239 Ser Arg Ser Leu Gln Ala Leu Glu Glu Leu Leu Ser Ala Cys Gly Gly 65 70 75 gac ttc tgc tct gcc ctc cct tgg ctg gct ctg ctt tct gcc aac ttc 287 Asp Phe Cys Ser Ala Leu Pro Trp Leu Ala Leu Leu Ser Ala Asn Phe 80 85 90 95 agc tac aat gca ctg acc gcc tta gac agc tcc ctg cgc ctc ttg tca 335 Ser Tyr Asn Ala Leu Thr Ala Leu Asp Ser Ser Leu Arg Leu Leu Ser 100 105 110 gct ctg cgt ttc ttg aac cta agc cac aat caa gtc cag gac tgt cag 383 Ala Leu Arg Phe Leu Asn Leu Ser His Asn Gln Val Gln Asp Cys Gln 115 120 125 gga ttc ctg atg gat ttg tgt gag ctc cac cat ctg gac atc tcc tat 431 Gly Phe Leu Met Asp Leu Cys Glu Leu His His Leu Asp Ile Ser Tyr 130 135 140 aat cgc ctg cat ttg gtg cca aga atg gga ccc tca ggg gct gct ctg 479 Asn Arg Leu His Leu Val Pro Arg Met Gly Pro Ser Gly Ala Ala Leu 145 150 155 ggg gtc ctg ata ctg cga ggc aat gag ctt cgg agc ctg cat ggc cta 527 Gly Val Leu Ile Leu Arg Gly Asn Glu Leu Arg Ser Leu His Gly Leu 160 165 170 175 gag cag ctg agg aat ctg cgg cac ctg gat ttg gca tac aac ctg ctg 575 Glu Gln Leu Arg Asn Leu Arg His Leu Asp Leu Ala Tyr Asn Leu Leu 180 185 190 gaa gga cac cgg gag ctg tca cca ctg tgg ctg ctg gct gag ctc cgc 623 Glu Gly His Arg Glu Leu Ser Pro Leu Trp Leu Leu Ala Glu Leu Arg 195 200 205 aag ctc tac ctg gag ggg aac cct ctt tgg ttc cac cct gag cac cga 671 Lys Leu Tyr Leu Glu Gly Asn Pro Leu Trp Phe His Pro Glu His Arg 210 215 220 gca gcc act gcc cag tac ttg tca ccc cgg gcc agg gat gct gct act 719 Ala Ala Thr Ala Gln Tyr Leu Ser Pro Arg Ala Arg Asp Ala Ala Thr 225 230 235 ggc ttc ctt ctc gat ggc aag gtc ttg tca ctg aca gat ttt cag act 767 Gly Phe Leu Leu Asp Gly Lys Val Leu Ser Leu Thr Asp Phe Gln Thr 240 245 250 255 cac aca tcc ttg ggg ctc agc ccc atg ggc cca cct ttg ccc tgg cca 815 His Thr Ser Leu Gly Leu Ser Pro Met Gly Pro Pro Leu Pro Trp Pro 260 265 270 gtg ggg agt act cct gaa acc tca ggt ggc cct gac ctg agt gac agc 863 Val Gly Ser Thr Pro Glu Thr Ser Gly Gly Pro Asp Leu Ser Asp Ser 275 280 285 ctc tcc tca ggg ggt gtt gtg acc cag ccc ctg ctt cat aag gtt aag 911 Leu Ser Ser Gly Gly Val Val Thr Gln Pro Leu Leu His Lys Val Lys 290 295 300 agc cga gtc cgt gtg agg cgg gca agc atc tct gaa ccc agt gat acg 959 Ser Arg Val Arg Val Arg Arg Ala Ser Ile Ser Glu Pro Ser Asp Thr 305 310 315 gac ccg gag ccc cga act ctg aac ccc tct ccg gct gga tgg ttc gtg 1007 Asp Pro Glu Pro Arg Thr Leu Asn Pro Ser Pro Ala Gly Trp Phe Val 320 325 330 335 cag cag cac ccg gag ctg gag ctc atg agc agc ttc cgg gaa cgg ttc 1055 Gln Gln His Pro Glu Leu Glu Leu Met Ser Ser Phe Arg Glu Arg Phe 340 345 350 ggc cgc aac tgg ctg cag tac agg agt cac ctg gag ccc tcc gga aac 1103 Gly Arg Asn Trp Leu Gln Tyr Arg Ser His Leu Glu Pro Ser Gly Asn 355 360 365 cct ctg ccg gcc acc ccc act act tct gca ccc agt gca cct cca gcc 1151 Pro Leu Pro Ala Thr Pro Thr Thr Ser Ala Pro Ser Ala Pro Pro Ala 370 375 380 agc tcc cag ggc ccc gac act gca ccc aga cct tca ccc ccg cag gag 1199 Ser Ser Gln Gly Pro Asp Thr Ala Pro Arg Pro Ser Pro Pro Gln Glu 385 390 395 gaa gcc aga ggc ccc cag gag tca cca cag aaa atg tca gag gag gtc 1247 Glu Ala Arg Gly Pro Gln Glu Ser Pro Gln Lys Met Ser Glu Glu Val 400 405 410 415 agg gcg gag cca cag gag gag gaa gag gag aag gag ggg aag gag gag 1295 Arg Ala Glu Pro Gln Glu Glu Glu Glu Glu Lys Glu Gly Lys Glu Glu 420 425 430 aag gag gag ggg gag atg gtg gaa cag gga gaa gag gag gca gga gag 1343 Lys Glu Glu Gly Glu Met Val Glu Gln Gly Glu Glu Glu Ala Gly Glu 435 440 445 gag gaa gaa gag gag cag gac cag aag gaa gtg gaa gcg gaa ctc tgt 1391 Glu Glu Glu Glu Glu Gln Asp Gln Lys Glu Val Glu Ala Glu Leu Cys 450 455 460 cgc ccc ttg ttg gtg tgt ccc ctg gag ggg cct gag ggc gta cgg ggc 1439 Arg Pro Leu Leu Val Cys Pro Leu Glu Gly Pro Glu Gly Val Arg Gly 465 470 475 agg gaa tgc ttt ctc agg gtc act tct gcc cac ctg ttt gag gtg gaa 1487 Arg Glu Cys Phe Leu Arg Val Thr Ser Ala His Leu Phe Glu Val Glu 480 485 490 495 ctc caa gca gct cgc acc ttg gag cga ctg gag ctc cag agt ctg gag 1535 Leu Gln Ala Ala Arg Thr Leu Glu Arg Leu Glu Leu Gln Ser Leu Glu 500 505 510 gca gct gag ata gag ccg gag gcc cag gcc cag agg tcg ccc agg ccc 1583 Ala Ala Glu Ile Glu Pro Glu Ala Gln Ala Gln Arg Ser Pro Arg Pro 515 520 525 acg ggc tca gat ctg ctc cct gga gcc ccc atc ctc agt ctg cgc ttc 1631 Thr Gly Ser Asp Leu Leu Pro Gly Ala Pro Ile Leu Ser Leu Arg Phe 530 535 540 tcc tac atc tgc cct gac cgg cag ttg cgt cgc tat ttg gtg ctg gag 1679 Ser Tyr Ile Cys Pro Asp Arg Gln Leu Arg Arg Tyr Leu Val Leu Glu 545 550 555 cct gat gcc cac gca gct gtc cag gag ctg ctt gcc gtg ttg acc cca 1727 Pro Asp Ala His Ala Ala Val Gln Glu Leu Leu Ala Val Leu Thr Pro 560 565 570 575 gtc acc aat gtg gct cgg gaa cag ctt ggg gag gcc agg gac ctc ctg 1775 Val Thr Asn Val Ala Arg Glu Gln Leu Gly Glu Ala Arg Asp Leu Leu 580 585 590 ctg ggt aga ttc cag tgt cta cgc tgt ggc cat gag ttc aag cca gag 1823 Leu Gly Arg Phe Gln Cys Leu Arg Cys Gly His Glu Phe Lys Pro Glu 595 600 605 gag ccc agg atg gga tta gac agt gag gaa ggc tgg agg cct ctg ttc 1871 Glu Pro Arg Met Gly Leu Asp Ser Glu Glu Gly Trp Arg Pro Leu Phe 610 615 620 caa aag aca gaa tct cct gct gtg tgt cct aac tgt ggt agt gac cac 1919 Gln Lys Thr Glu Ser Pro Ala Val Cys Pro Asn Cys Gly Ser Asp His 625 630 635 gtg gtt ctc ctc gct gtg tct cgg gga acc ccc aac agg gag cgg aaa 1967 Val Val Leu Leu Ala Val Ser Arg Gly Thr Pro Asn Arg Glu Arg Lys 640 645 650 655 cag gga gag cag tct ctg gct cct tct ccg ttt gcc agc cct gtc tgc 2015 Gln Gly Glu Gln Ser Leu Ala Pro Ser Pro Phe Ala Ser Pro Val Cys 660 665 670 cac cct cct ggc cat ggt gac cac ctt gac agg gcc aag aac agc cca 2063 His Pro Pro Gly His Gly Asp His Leu Asp Arg Ala Lys Asn Ser Pro 675 680 685 cct cag gca ccg agc acc cgt gac cat ggt agt tgg agc ctc agt ccc 2111 Pro Gln Ala Pro Ser Thr Arg Asp His Gly Ser Trp Ser Leu Ser Pro 690 695 700 ccc cct gag cgc tgt ggc ctc cgc tct gtg gac cac cga ctc cgg ctc 2159 Pro Pro Glu Arg Cys Gly Leu Arg Ser Val Asp His Arg Leu Arg Leu 705 710 715 ttc ctg gat gtt gag gtg ttc agc gat gcc cag gag gag ttc cag tgc 2207 Phe Leu Asp Val Glu Val Phe Ser Asp Ala Gln Glu Glu Phe Gln Cys 720 725 730 735 tgc ctc aag gtg cca gtg gca ttg gca ggc cac act ggg gag ttc atg 2255 Cys Leu Lys Val Pro Val Ala Leu Ala Gly His Thr Gly Glu Phe Met 740 745 750 tgc ctt gtg gtt gtg tct gac cgc agg ctg tac ctg ttg aag gtg act 2303 Cys Leu Val Val Val Ser Asp Arg Arg Leu Tyr Leu Leu Lys Val Thr 755 760 765 ggg gag atg cgt gag cct cca gct agc tgg ctg cag ctg acc ctg gct 2351 Gly Glu Met Arg Glu Pro Pro Ala Ser Trp Leu Gln Leu Thr Leu Ala 770 775 780 gtt ccc ctg cag gat ctg agt ggc ata gag ctg ggc ctg gca ggc cag 2399 Val Pro Leu Gln Asp Leu Ser Gly Ile Glu Leu Gly Leu Ala Gly Gln 785 790 795 agc ctg cgg cta gag tgg gca gct ggg gcg ggc cgc tgt gtg ctg ctg 2447 Ser Leu Arg Leu Glu Trp Ala Ala Gly Ala Gly Arg Cys Val Leu Leu 800 805 810 815 ccc cga gat gcc agg cat tgc cgg gcc ttc cta gag gag ctc ctt gat 2495 Pro Arg Asp Ala Arg His Cys Arg Ala Phe Leu Glu Glu Leu Leu Asp 820 825 830 gtc ttg cag tct ctg ccc cct gcc tgg agg aac tgt gtc agt gcc aca 2543 Val Leu Gln Ser Leu Pro Pro Ala Trp Arg Asn Cys Val Ser Ala Thr 835 840 845 gag gag gag gtc acc ccc cag cac cgg ctc tgg cca ttg ctg gaa aaa 2591 Glu Glu Glu Val Thr Pro Gln His Arg Leu Trp Pro Leu Leu Glu Lys 850 855 860 gac tca tcc ttg gag gct cgc cag ttc ttc tac ctt cgg gcg ttc ctg 2639 Asp Ser Ser Leu Glu Ala Arg Gln Phe Phe Tyr Leu Arg Ala Phe Leu 865 870 875 gtt gaa ggc cct tcc acc tgc ctc gta tcc ctg ttg ctg act ccg tcc 2687 Val Glu Gly Pro Ser Thr Cys Leu Val Ser Leu Leu Leu Thr Pro Ser 880 885 890 895 acc ctg ttc ctg tta gat gag gat gct gca ggg tcc ccg gca gag ccc 2735 Thr Leu Phe Leu Leu Asp Glu Asp Ala Ala Gly Ser Pro Ala Glu Pro 900 905 910 tct cct cca gca gca tct ggc gaa gcc tct gag aag gtg cct ccc tcg 2783 Ser Pro Pro Ala Ala Ser Gly Glu Ala Ser Glu Lys Val Pro Pro Ser 915 920 925 ggg ccg ggc cct gct gtg cgt gtc agg gag cag cag cca ctc agc agc 2831 Gly Pro Gly Pro Ala Val Arg Val Arg Glu Gln Gln Pro Leu Ser Ser 930 935 940 ctg agc tcc gtg ctg ctc tac cgc tca gcc cct gag gac ttg cgg ctg 2879 Leu Ser Ser Val Leu Leu Tyr Arg Ser Ala Pro Glu Asp Leu Arg Leu 945 950 955 ctc ttc tac gat gag gtg tcc cgg ctg gag agc ttt tgg gca ctc cgt 2927 Leu Phe Tyr Asp Glu Val Ser Arg Leu Glu Ser Phe Trp Ala Leu Arg 960 965 970 975 gtg gtg tgt cag gag cag ctg aca gcc ctg ctt gcc tgg atc cgg gaa 2975 Val Val Cys Gln Glu Gln Leu Thr Ala Leu Leu Ala Trp Ile Arg Glu 980 985 990 cca tgg gag gag ctg ttt tcc atc gga ctc cgg aca gtg atc caa gag 3023 Pro Trp Glu Glu Leu Phe Ser Ile Gly Leu Arg Thr Val Ile Gln Glu 995 1000 1005 gcg ctg gcc ctt gac cga tgagggtccc acgctgacct tggccctgac 3071 Ala Leu Ala Leu Asp Arg 1010 ctcaggagcc acgctgtaga cattccctct cctggtctct gggtctggct tccaggctct 3131 ggctgtggat gtcttcagcc tctgggtgct ggccagtgag gtcccaaatg acccagggct 3191 taagggagag gcgagagaat gatctggcct caggggacag gccacctggt caggaggaat 3251 atttttcctg cactttttct caggtatcaa taaagttgtt tccaactc 3299 <210> 37 <211> 6814 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (517)..(849) <400> 37 ggttcattgc cttgtgtcct ctgctccggg agacttcggt gattctgcca ctcactccgt 60 cgctctgtga cctgctggca ttgaatgatt tatagctaag actccaggac acccctgaag 120 ccgagaaatg tggaaaagcg agattgtctt tgaccatttg ctatggacat tgtcagggat 180 ggtgcagcct gaatgagaat gtctgcggta tttcccgaaa taagtatccc tcaaggatga 240 tactgtggac ctcactcagg aagaatgtgt ccttcaggga aagctgcaca gagacgtgat 300 gctggagaag cagtcatctg gttactttag catgaatgag agatcctttc gcttcacgtc 360 tttgccagca tttggtgttg tcagtgttct agattttggc cattatagta catgacttca 420 ggctcctatg tgcagaagtc ctcaaccccc aggctgcaga ccagtacctg tccatggcct 480 gttaggaaac tggccgcaca gcaggaggtg aaatga tta ttg cag ttt cga ggg 534 Leu Leu Gln Phe Arg Gly 1 5 gag atg atg tca caa gat ctc gaa ccc ata tct cag aac cgc ctg cct 582 Glu Met Met Ser Gln Asp Leu Glu Pro Ile Ser Gln Asn Arg Leu Pro 10 15 20 cct ccc aca cac tct ggc tgt cct gac cat cac ttc aag ccc acc agc 630 Pro Pro Thr His Ser Gly Cys Pro Asp His His Phe Lys Pro Thr Ser 25 30 35 cct gca gca aaa aaa atc aaa cga gta gtt cag aag gca aag tct gca 678 Pro Ala Ala Lys Lys Ile Lys Arg Val Val Gln Lys Ala Lys Ser Ala 40 45 50 agg gaa gga agt ata ttg gga ggt aca gta agt att cct gtc tgg aga 726 Arg Glu Gly Ser Ile Leu Gly Gly Thr Val Ser Ile Pro Val Trp Arg 55 60 65 70 agg tct tct ttg ggg cta gaa act gag cca gtg cta aag cca tgc agg 774 Arg Ser Ser Leu Gly Leu Glu Thr Glu Pro Val Leu Lys Pro Cys Arg 75 80 85 aag gag gaa ata atc agt gag cca cgg gct gaa ctt gtg gaa aag aaa 822 Lys Glu Glu Ile Ile Ser Glu Pro Arg Ala Glu Leu Val Glu Lys Lys 90 95 100 tgg agg gca agg tca caa acc agt ccc taactgcttc taatttaatg 869 Trp Arg Ala Arg Ser Gln Thr Ser Pro 105 110 taatcctcac tgtttgtcat tattgctttt gatggccatg aaatctgttt tttcccagtt 929 ctctagtgta atttggaatt aatttcccag ctgctttatt ttttttctag aagagtcggg 989 gacattttca ggattagtag aggtgtttct acaacacctt catgccttcg atagtgtgta 1049 agagttcacc aattgaatta ccttattctg ttcagaagta gtaactatgg agtttaacca 1109 ctctggacat attatatact taatggagac catagctgtg tggtgactga aaacatgcat 1169 tgtctactcc ttatggtgag actgctttcc ttcatgaagt cagtaaagaa gggtaacttt 1229 tctgtagatt tttgtatttt taaaaaaggt caagatcttc ggcagttttc tgaattgaat 1289 tgtttgtgat atttgctctg tttttaaaat cttctaaggc cattaccagg ttcagtgctt 1349 atcttagtac aatttaaatt gattccgtga ataatttttc ctgcctccag tttccctttt 1409 acatagtggg ctcatgtttt aatatgttaa acaattctga cattgaaata attttatttt 1469 atatttttgc atccacaaat actaattttc tccatatatt aatggtgatg tagtttctcc 1529 tctgcaatat tttattgcct actcatgttt tatgtcccct ggattacagc actgtcattc 1589 cactgtgccc tatttcttgg ttatgatgaa aagactctta attccagtat gaaatcattt 1649 ctgcattcca taaatttcat ttggcatctg tggaattaag gcatcttcat tgtatttgga 1709 tctctgaatc ataagtgata tttgcctata aattaagcaa tgatatttaa ataagagatt 1769 accacaatca tattttataa atatacaacc atttttaaaa acctgacaaa atctacaaaa 1829 aaaagaaaat gaaatatatg tggagtttta gaaaagactg actaggtcca aggttgaggc 1889 acatagtggt taagcacatt gtcagctccg gactctgcct cttacaagga aggagggggc 1949 tttagatgtt atttagctgt tatttagcct ttctacacct aagttcccct cacctgtaaa 2009 aaaaaaaata ataataaatt gcttactttg tagaatcatt gtaaatgttc tatgtaaaat 2069 atgaatatag tactcacagt aaatatgtgt gtgtgtggtg tgtggtgtgt ggtgtgtagt 2129 tcagcaatag aaaatggaat ttaataagaa cgttatgagt tgaaaacaat ggtctgtgga 2189 caatattgaa tttcagttgc caaaataaaa tagacctcat gtttcccttc aggatcctct 2249 aactctgaat atgaatagaa gtatcagtca ctggaaaaga acaaatgtcc tctagggatg 2309 tggcaatagg aataatctta tctcagacca taattgggtt cctgatgaaa atattttttc 2369 tttagcattg tatttctctt tatttcacca aatgcacatt aaggtctaca gatctgattc 2429 tcaaacacct ggctgtagcc acctcctttg tgatacttta taaaggagcc ccacagagaa 2489 tgcctgcttt tgggttgaaa cattttctca atcataatta ggtacaaact tgttttctat 2549 gttcacaaag tgggcagggc tgtgtgcatt ggcaccactt gccttttgaa tatcttctag 2609 gccatcacag tcagccccat gtactcctgc tgggcagacc tgaaactaca agctcccaaa 2669 tagaatgggt gctccaacat cctctgctgg attgtgatat gctggtaacc gcacgtgact 2729 ggcaagtgga atggcgaaaa caacacaaag aaggatttgg ttactgttct gcagtagtta 2789 ataactgata tggtttggct atgtccccac tcaaacctca tcttgaattc ctatgtgttg 2849 tgggaggaac ttggtgggag gtgattgaat tatgggggca ggtcttttct gtattgttct 2909 cgggatggtg aatgagtctc atgagacctg atggttttaa aaacaggagt ttccctgtac 2969 aagctctctc tttgcctgct cccatccatg taagacctga cttgctcctg cttaccttcc 3029 gccatgattg tgaggcctcc ccaaccatgt ggaactgaaa gtttgttaaa cctttttttc 3089 ttcccagtct tgggtatgtc tttatcagca atgtgaaaaa aaatggacta atacagcaaa 3149 gtggtatcag tagagtgggg tgctgctgaa aagataccca aaaatttgga agcgactttg 3209 gaactgggta acagggaaag gttggaatac ttgagatggc tcaaaagaag aaaggaaaat 3269 gtgggaaagt ttggaacttc ctagagactt gttgaatggt tttacccaaa atgctgatag 3329 caataaagtc caggctaagg tggtctcaga tggagatgag gaacttgttg gaaactggag 3389 caaaggtgac tctcgttatg ttttagcaaa gagactgatg gtattttgcc cctgccctag 3449 agatttgtgg aactttgaac ttgagagaga tgatttaggg tatctggcag aagaaatttc 3509 taagcagcaa agcattcaag aggtgacttg ggtgctgtta aaggcattca ttttttaaat 3569 caatacctcc tgaagtcctc ctgagagcgc cagatatgca ttcgggccac atggagcaga 3629 aaaggagggc tccatcactc cctgctggcc atcagggtgc agtgcaggac actcagagct 3689 caatacttag ttgtttccca gtgccccctg ctagacctcc taccgaatcc tgaaattctc 3749 aatttcttga tctgtctgct cctttggctg aacatgcgtc aaatccacgg gagcatcaca 3809 aaaggattct ttctcagtca tgcctgtgtg ataggacctt cttccagttt ctttcaaaaa 3869 ttgaaaaaaa catctgaatg atgcagtcta cacttctatc ctcagactct gctgcagagc 3929 ttcatcctgc aggacacaga tgactacagg gctgtttgag atggaatctt cctttctaaa 3989 tcttctaggt ttgatcacag tcacaaatga gcagagcaga tgaaagtgaa aaatcttctg 4049 gcttgtccct atttggggag agctctccag aagtattttc aagaaattag tagctattcg 4109 agggagtgaa atacagctgg tttgccttcg agaaaggaaa gtgaagtgtg cttttgtttc 4169 ctctcattta acagttgcaa aaggcaaatt ataaaatagg aatactcatg acactttctt 4229 ataaatactg ctaaacaaaa taatctacat tcatattttt gtactggtaa aatatctgaa 4289 agcaaaatca tgggaagata tttaagtata ttatacatca tgaatttcaa aaacagagtg 4349 aagatcatga tacaggtttc ttatatgaat aactgtatgg tttatatttt ccttcgcctt 4409 ttgaaatact caggaaatgt ttgttgtaca cagaatttga ataaaaattg tccaggccag 4469 gtgcagtggc tcacacctat aatcccagca ctttgggagg ccaaggcagg cagatcacct 4529 gaggtcagaa gttcaagacc agcctgacca atatggtgaa accttgcctc tactaaaaat 4589 gcaaacatta gctgggcgtg atggcaagtg cctgtagtcc cagctacttg agaggctgag 4649 ataggagaat tgcttgaacc caggaggcgg aggttgcagt gagccgagat tgtgccactg 4709 cactccagcc tgggcgacag agtgagactc catctcaaaa taaataaata aataaataaa 4769 taaataaata aatataaaaa taaaaatttc catgcaaact tttcttcaat atatttttgt 4829 tacagttaac gtaaaattag ctgttgtaat agacaaacct gaatttatca gcagtttgat 4889 catcatgtaa tatttatcat tgctggcata taccacctca acacaggctt tcaaatgtca 4949 tgtgactctg cttgtggatt ttcctccaaa tatggattta gggaccccca taccttctat 5009 tggtgtattt ctcattgcta acctgtgtct tcaaatctgg ctatggtgct tgggaaaatt 5069 tcatgcagtt gtatggcaaa aaatatttgg ggcttcacag agggtgtttt cacaggtcag 5129 gcctgtacca ggtaaatgtc gtttccaccc actcagctag gatgcttgta tggccagacc 5189 tcagaacaaa aagcctgggg aagggagtct tgaactgtga gaccagcggg aatacaagat 5249 tggtctggtg aataagacca ctgtttttct tacactatgt gaaaaaaatg ctgttaatat 5309 gagcaacagc cggttttcct gctttcatac atttacgcaa gaaaatgtga cttaaaatct 5369 aattccacag attaaaccta gagaatatat ttcagggaag agggcaaaaa ggtcaataag 5429 gctcacactg ttgaccatct gaaaggggat tcccattgaa tcccaaaagc acagagtaga 5489 gttgaaatat tccctagaca agtgttgtca aaaaaaatat gaaagtacat tacatatgta 5549 ggaatattta gatatgaact gacactagtg ccaacactca gtcaccacga gaggccctca 5609 agcatccagg atagcctgtt cttccctcag cataaccata atgtaacaag ctaacctttt 5669 cacaaagggt ggctatgatt ataaaccgag tatcagtaat gagttaacac aggcaacgat 5729 aatatcttgc tactgtaact taaaaacgtg tttttatgtc catcaaaatc aagtagtgat 5789 tgtgcataaa attttgtaat atttaagggt taggtatcca tcaaacatgt tacagaccag 5849 gcagttactc cagaaatacc tttaaaagga gagaattatt gcaaaccaca taagatattt 5909 agtctgcatt aggaaatgaa aatgcaagaa acattctgca atgtggaatg aacaaatatg 5969 attccttaaa atgcataaaa ctcagcaagg acagaaaacc acgctgtttc tccactgtgc 6029 tgcaaacaca gtggtcaaca aaaccacatt aacattttgc catgcctttg tcaataactt 6089 ttcttggcag cctcagatat agccttcact tgcaagacaa gttgaaaggg tcttgtaaca 6149 tctttctctt ttgaaaacca atttatcaaa atgaaaacct tttattgttg atttcaccat 6209 aaagttagta gaatctcaga aaagatacag ataatgcata tgtgtctgag aaagagctcc 6269 tgtaaagccc aacaccaaat acaggtcata tcatagaagt attggtgtcc tgcattttgc 6329 tcttgtaatt atacctgcgt ttattactct ggggagattc tcaggaccag cattgctgca 6389 ttttgctttt ctatatttta attgttaata gatattgttt ggttgccagc ccctaaatgt 6449 ggaacacttt ataatcgtaa tatgcaaggt atgagaacac agtacttctt tcatcatctg 6509 tgatgtatga ttattcaccc taattttctt gagtctgagc agtttaacgg aggtatattt 6569 ttattagttc actattgttt aaatttcttg tcttttcatg ctaaaaggaa agttgatatt 6629 tatctatatc tatgtctgta tatgcatgta tatctataga agtagatcca tttgtttgaa 6689 caaccctctg taattaattg tgatgaatta tgcctgtttt agaaagtatt ttgtacacat 6749 atttttaata aaaattttcc ccccgaatat ttaaccagta tgacattaaa agagtcagga 6809 atttg 6814 <210> 38 <211> 6734 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2994)..(4055) <400> 38 caggagacct cccaggaccc tgcaggaaac attcctcatt cacagcatgg gggcctcagc 60 tcctcacctt cccagagcaa cccaggctcc cagaggcccc cgcctacaca gtgccttttc 120 tggcactgct gtgactgtct ccatcactct gtgcctgtga cagtagcact tccttgcaag 180 tttattttct cccaaatctc tttaagtcca ggacattttc tggaaaactg gaagactgga 240 cacaggactg cccccaagca ctggggaagg agggagaatc ccatcttcct gcagctttta 300 tcagagggaa tgcatttaga taagggccaa gggagaaaac agtcctcaga aagtgtggag 360 ggaagtgggg tacaggcctg gacgcctgga attggagaaa ggggagacct ggagaggcag 420 acgtggggat ttcttcaccc cacttttact gcccctatca taagaggctc ccagagggcc 480 atgtgtgagt cactgttctg cactgtcccc tgcgtagact cgactgaagc aggaggaagg 540 agcccccggt aacaccctgg gtgggactgg ggaggccagg gctttggggc ttttcctttc 600 ctaagggcgg tgccatggaa tcttttggct ggagatgaca ttggggtttc tttccctgtg 660 cccagctcca agcaggtcgc tgtgtggcca ccccacccaa aggaatgcac gggttgctgg 720 ctgggagatt cttcaagagc acacactctc aggcccgatc gagctgttct cagtttttgg 780 gtttcccata gaaaacccaa agttttatct tccagcttct tgacaggaaa agtgggcaga 840 aagccttttc cccaccacac tgataaaagg cgtttgagta ctgaaacgtt cttaaaggct 900 gtgtggcttg gctcaccaaa gcagcctcct ggtgcttctc aggtggcctt gaacacagcc 960 tgggccactt gcctgccggc ctcgcccagg aggcacactg tggacccttc caggctgccc 1020 tggccctggg cacagccttg gtttggagtg gggagagttg ggggtgatgc ctggcctggg 1080 gctggactgc tgggagaatg tgctgtcatt gagttctttt cccggcagcc actccgggca 1140 tgggcacaca cccttgttct gtcattggtc aggggacacc aggacaagct gtcccgggag 1200 gcaggcatcc tggggaagga aggagaattc catcttcctg tagcttttat cagagtgaat 1260 gcatttagat aagggccaag agagaatact acctagagag tgtggaagga agtgggggtg 1320 caggcctgta ctcctggaat tagagaaggg ggaggcctgg ctcttgtctc acagactcca 1380 ggctctctcc ttctgagccc agttgttcct ccagcagtac ctggcatggg gttggttctg 1440 taggatggag cctgaagctg cgttttctgt gggttccgtc ttcctctggg atggaggctt 1500 ctgagcaggg agggatttga gctttcatgc agcagtgagg ggctgagggc atgagctgtg 1560 gagggggctc ctgctcctca gagtggaagc agagccatcg aatcagccag gacaggagtc 1620 atcccaaagg ccagaggccc caagtgttga tgctccccat agaaggagcc cgctaataac 1680 actctccagc acataacccc tggcatcttc gccaccacca agagtgctgc cccagactct 1740 cggcacccac cgcacgctaa tcatctctgg cagtttctgt tggcctttgt ctccttaact 1800 ctcctcctct tctaaattgt aagtagtcag ctttcatcca cgcgataaca cgtgcatttc 1860 aagcaaaaca gccaaccaca agcccagccc accaacgcac tgcgcgcctc gttagaggtt 1920 agcgtccatc tctgacaaat gcatgttctc ctggctttgt tttctaaccc acgcctcctg 1980 tctgctgagc cttgctgcct gtttggtgag gagtgtgtgt gtctggtgtg cttttgtgct 2040 attaactctt acacgggttt gctctccgga cctattcgct ggttacccta aaacccgtaa 2100 aggacacacc aggagctggt aaccagtgca gagggacagt cctatccatt tttatagccc 2160 tttggagggg aacactctgc ctgcttctgc atgctgtgtt catgagcagt tttgtaacta 2220 gaccctccta gggatctgga gtcaaatgtg aaattcccaa ggataccggc ccagtgcagg 2280 tttatgaaga tggcaagaaa gaggtctggg gacagggagt tttgttcctc cccattgtga 2340 ggggaaggaa agggtcagag agaccagcct ccctccggag ggtgtcaggg tttatagtca 2400 ctgggctcag ccagcggctc accgtgcacc ctcaaacaag caggctcctc tcctgggtct 2460 tagttgcctg tctaggtccc atgatctaaa tctttgacct cactacttgc ccttataaag 2520 aacaaagtta caagcattct gtcctgcaga cagagcaggt ggcctcgtag gaagttcaga 2580 gccagtgccc actgctctgc aacattttcc accccgggga cccttgtcaa tttgcaaaat 2640 ttcatctgag cctctgtacg tgggggaaag aaaggtcccc tcatagtcat gggtgaaaag 2700 tggtaggccc ccgtgtgtat tgtaggttgg ctgccctggt aaggcttaga taacgaactg 2760 aaagaccctt gtaattagcc aagactgggc cccagaagag aggcgaaaag agcatcaatt 2820 gcccacgagt ggtcctggag caaggggaca cactgggctt cacacactag gtcagcaggt 2880 gtttcaaagc tagtgaccca ctttgcctga catgaggagt tgaagccagg catccagact 2940 tcccggtggc tgccagctgc caggaccaca gcctagggca gctcacaagg tga ggg 2996 Gly 1 gaa gtc agt ggc ccc agc act tgg gtg ttg tcc tca gag aga tca gca 3044 Glu Val Ser Gly Pro Ser Thr Trp Val Leu Ser Ser Glu Arg Ser Ala 5 10 15 cta atc acg gtg ttg cgc tca aca gtg aag gag aag cca cag tat ggc 3092 Leu Ile Thr Val Leu Arg Ser Thr Val Lys Glu Lys Pro Gln Tyr Gly 20 25 30 aag aac ccc gtg gtg atg gtg gac gag att atg agc tcc agc cct ccc 3140 Lys Asn Pro Val Val Met Val Asp Glu Ile Met Ser Ser Ser Pro Pro 35 40 45 aag ttc acc ttc cct gaa gca ggc tta cga atc atg atc acc aat aag 3188 Lys Phe Thr Phe Pro Glu Ala Gly Leu Arg Ile Met Ile Thr Asn Lys 50 55 60 65 ttt gga ccc agg acc cga cta cgg atg gcc agc agg atc atc att aat 3236 Phe Gly Pro Arg Thr Arg Leu Arg Met Ala Ser Arg Ile Ile Ile Asn 70 75 80 gag cgg cag aga ctg atc aac tcg gcc aat ggt gtg agc agt aag ccg 3284 Glu Arg Gln Arg Leu Ile Asn Ser Ala Asn Gly Val Ser Ser Lys Pro 85 90 95 ctt caa aac ggg agg cac gag aac att gag aac ggg aat gtt cct gtg 3332 Leu Gln Asn Gly Arg His Glu Asn Ile Glu Asn Gly Asn Val Pro Val 100 105 110 gaa aac ccc gaa gac cct cag cag aat cag gag cag cag ccg ccg cca 3380 Glu Asn Pro Glu Asp Pro Gln Gln Asn Gln Glu Gln Gln Pro Pro Pro 115 120 125 cag cca cca ccg cca gag cca gag ccg gtg gag gct gac ttc ctg tcc 3428 Gln Pro Pro Pro Pro Glu Pro Glu Pro Val Glu Ala Asp Phe Leu Ser 130 135 140 145 ccc ttc tcc gtg ccg gag gcc aga ggg gac aag gtc aag tgg gtg ttc 3476 Pro Phe Ser Val Pro Glu Ala Arg Gly Asp Lys Val Lys Trp Val Phe 150 155 160 acc tgg ccc ctc atc ttc ctc ctg tgc gtc acc att ccc aac tgc agc 3524 Thr Trp Pro Leu Ile Phe Leu Leu Cys Val Thr Ile Pro Asn Cys Ser 165 170 175 aag ccc cgc tgg gag aag ttc ttc atg gtc acc ttc atc acc gcc acg 3572 Lys Pro Arg Trp Glu Lys Phe Phe Met Val Thr Phe Ile Thr Ala Thr 180 185 190 ctg tgg atc gct gtg ttc tcc tac atc atg gtg tgg ctg gtg act att 3620 Leu Trp Ile Ala Val Phe Ser Tyr Ile Met Val Trp Leu Val Thr Ile 195 200 205 atc gga tac aca ctt ggg atc ccg gat gtc atc atg ggc att act ttc 3668 Ile Gly Tyr Thr Leu Gly Ile Pro Asp Val Ile Met Gly Ile Thr Phe 210 215 220 225 ctg gca gca ggg aca agt gtt cca gac tgc atg gcc agc cta att gtg 3716 Leu Ala Ala Gly Thr Ser Val Pro Asp Cys Met Ala Ser Leu Ile Val 230 235 240 gcg aga caa ggc ctt ggg gac atg gca gtc tcc aac acc ata gga agc 3764 Ala Arg Gln Gly Leu Gly Asp Met Ala Val Ser Asn Thr Ile Gly Ser 245 250 255 aac gtg ttt gac atc ctg gta gga ctt ggt gta ccg tgg ggc ctg cag 3812 Asn Val Phe Asp Ile Leu Val Gly Leu Gly Val Pro Trp Gly Leu Gln 260 265 270 acc atg gtt gtt aat tat gga tca aca gtg aag atc aac agc cgg ggg 3860 Thr Met Val Val Asn Tyr Gly Ser Thr Val Lys Ile Asn Ser Arg Gly 275 280 285 ctg gtc tat tcc gtg gtc ctg ttg ctg ggc tct gtc gct ctc acc gtc 3908 Leu Val Tyr Ser Val Val Leu Leu Leu Gly Ser Val Ala Leu Thr Val 290 295 300 305 ctc ggc atc cac cta aac aag tgg cga ctg gac cgg aag ctg ggt gtc 3956 Leu Gly Ile His Leu Asn Lys Trp Arg Leu Asp Arg Lys Leu Gly Val 310 315 320 tac gtg ctg gtt ctc tac gcc atc ttc ttg tgc ttc tcc ata atg ata 4004 Tyr Val Leu Val Leu Tyr Ala Ile Phe Leu Cys Phe Ser Ile Met Ile 325 330 335 gag ttt aac gtc ttt acc ttc gtc aac ttg ccg atg tgc cgg gaa gac 4052 Glu Phe Asn Val Phe Thr Phe Val Asn Leu Pro Met Cys Arg Glu Asp 340 345 350 gat tagcgctgag tcgcggcccc tgggagctga tctggacacc ctgtgacact 4105 Asp ggcgtcctcc tctcccctcc ttcccccacc acaggtctct cctgcatagg cagccactgt 4165 ccgttctttc acacactgga aggaagagcc atcgtggtct ttgtctggcc acaggccagg 4225 ctgctgggca tcctcctcct ccttggagtt ccacccctgc aaggctggat ttgggggcca 4285 ttatctgagc agcttcaaag acccctgagc tgccaaccac ggagatgtgc caagcatctc 4345 atctctcctg cacactttag tcagaaggac ttctgcatgc agtttgtctt tctgttctgc 4405 aggcagcttc agaattgagg tcatttgtga gcacaagatc tcatagggca ggtgcaaaat 4465 aggaatgttg ttctcaagtg tcacctccag cccagaggtg gttccttagg cagcatgtgc 4525 tcctgggagc ctctgacttt tgctggaagc acccacagtt tggaaggggc aagacctcaa 4585 cctgttgggg tttagggccc atgatggcag acattctacc ccttttcctg gaaaaactgg 4645 aagaatgaaa ataatttttt tctgtggaag agagaaaatg agtgaatatt cttctcactt 4705 ttattgatgc attcagagaa taagcaatga aatattaaaa aatgaaacat catataggtc 4765 atcatacttg aaaattatca ttccatatga aaggatcatg atacacacca aaaaagtaat 4825 gatcgtaaag acacaaatcc tctgtatgcc atcttgcatt ggcactgagg tgtttggttt 4885 ggaataggga aaaaggtaag agactaacgt ggaaaggtgc taactcagag actggagatt 4945 atagtttaca gctgtacttt ccagatcttc tatgtgacac aatgcactgt ccttgtgggt 5005 ttgtcattta ttggttaatg ctctagtttc aaaaccaccc tgttgaaagt tccagttatt 5065 tatatgccca acaaatttca tagcctgctg aactgaactg agtgtgtcag aagtgctggt 5125 taatgacgag aagagattgc ctgaaaaaca acaaactgct ttctggttag ctgaaggcaa 5185 gtgtgaaaat cagaatttag aatatttaga gctaagcttc tggaaccacg tagtttctac 5245 acgtggcagg ccaagaatgg gaggctgact caaaactaga tagaaaaata taaaataatc 5305 ttcgaccact tgatagctct caaatatata tttaaaagat ttatgaatac aaaccattta 5365 tggtttatga tttctaaaaa gaaagcacaa ttaattttat agagaggttt tttatttttt 5425 taatatttct attgcaaaag tctatccgat ttgatgcact ttgaatattg agatattttg 5485 cacggatgaa tgtatgggaa ctacccatga tgatgtaaga ggaaagaaca tttttttgtg 5545 attcaccaga catcacttta aacttggtga tgagtttaaa tccagtagct aatcccttcc 5605 tgagactcaa agatcgtgac gctggttgga atttctgact gtgcccttta gggcctcctg 5665 agtttcaaaa ggaggaagtg ttcgtgcttg tgtccctgaa gttccctgtt gcatgagcct 5725 gcgacaggac ctcaccccca ccaccaggct tctatttggg attcacatca gtattagtat 5785 cgtagctaca ccaagttcag gcttctcttt ttgttttttt acctagaaat tgggctcagt 5845 ggtcttcaac ttgaggacga gggtgatttt cctaagaaat cagcaaagag ggaaggcagg 5905 gcccctgtag attcaccagt ataaacttca gctgcaggga ttccagagcc ctcgggacca 5965 ctctgtcacc ttaatagcca agttctcctg gttcctccga tcttacaggc tcatccaggt 6025 tccaaagtgc ttctgtctct gttttgattc tccaaactgc tctgtgatgt atgtagggat 6085 tattctcccc acttaacaga aagtagtgtc ttggagaggt caagggtctc tagttcaatg 6145 gccagtcata gcagaaggga ggccaagcac cagtccatca cccctcccag gccagcctct 6205 gtaagttggc cacacttggg gagtgagtgt gggtatgact ttaccctcct ggttggttct 6265 tactgtttga gtcaaaacct catcaatata tcattgactc ctgggttcct caggtcattt 6325 cctaatatct gtccctatcc aatgcctcta ttttatcttg aaaaaaggac caaaaattat 6385 ttttagctat ggcaaggcac aggccacatg gcccctgatg gcgtccctgc tggttttcaa 6445 ttctctgaag ccttgtgtag ctttcagagc acacgtatcc taattaccct cctcttcctc 6505 agcagaaccc atttgagatt ctaaatgaat actcttagtc tctaaagttg cagttagaaa 6565 ctaaaataat gttttttaat atgtaatatg ctcctcttgg ctaattttct tttgacttta 6625 atgtgccaat gtaacttcct ttaaaggatc tatgcattta ttaaatctgg aaaactatat 6685 gtacactgta ggtggaaaat tctctttttt aactaaatat ttttccatc 6734 <210> 39 <211> 5499 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (83)..(1921) <400> 39 aatggcggaa gtggcaccgt tgccaggcag ccgttgcctg gcgtcgcggg gcgtactctg 60 cgctgggcgc gcggaggcct ag gcg gga agc tcg agc ggc ggc gcc atg gcc 112 Ala Gly Ser Ser Ser Gly Gly Ala Met Ala 1 5 10 cga ggt agc gcg cgg ctg gcg ggg gtc ccg agg atc ccg ggt tcc ggg 160 Arg Gly Ser Ala Arg Leu Ala Gly Val Pro Arg Ile Pro Gly Ser Gly 15 20 25 gtt ccg ggg tcc agg gtc ggc ggc cgg agc gct cag ggc ccc cgc cta 208 Val Pro Gly Ser Arg Val Gly Gly Arg Ser Ala Gln Gly Pro Arg Leu 30 35 40 ggc cct gag gcc aga gtc ccc gct cag gca ggg tcc cgt ctg ccg ggc 256 Gly Pro Glu Ala Arg Val Pro Ala Gln Ala Gly Ser Arg Leu Pro Gly 45 50 55 gcc cac cct cgg gct ccc gga gct tgg ctt ccc tcg ggc gcc cgg cct 304 Ala His Pro Arg Ala Pro Gly Ala Trp Leu Pro Ser Gly Ala Arg Pro 60 65 70 cgt ccc gcc agc cta gct ggc gtt ggc gtc gcc ggg gaa ggc gcg gag 352 Arg Pro Ala Ser Leu Ala Gly Val Gly Val Ala Gly Glu Gly Ala Glu 75 80 85 90 agc ccc ggc tcc tgc ctg gtc ccc gag gcc cgg ccc agc ccc gca gtg 400 Ser Pro Gly Ser Cys Leu Val Pro Glu Ala Arg Pro Ser Pro Ala Val 95 100 105 gcc ccg gct cgc gtg gcc gag tcc cct gac gcc cgg cgc ccg ctc ccc 448 Ala Pro Ala Arg Val Ala Glu Ser Pro Asp Ala Arg Arg Pro Leu Pro 110 115 120 gca gcg tgg cag cac ccg ttc ctc aac gtc ttc aga cac ttc cgg gtg 496 Ala Ala Trp Gln His Pro Phe Leu Asn Val Phe Arg His Phe Arg Val 125 130 135 gac gag tgg aag cgc tcc gcc aag cag ggg gac gtg gcc gtg gtc acg 544 Asp Glu Trp Lys Arg Ser Ala Lys Gln Gly Asp Val Ala Val Val Thr 140 145 150 gac aag acc ctg aag ggc gcc gtg tat cgc att cgg ggc tca gtc tct 592 Asp Lys Thr Leu Lys Gly Ala Val Tyr Arg Ile Arg Gly Ser Val Ser 155 160 165 170 gcc gcc aac tac atc cag ctc cct aag agc agc acc cag tct ctg ggg 640 Ala Ala Asn Tyr Ile Gln Leu Pro Lys Ser Ser Thr Gln Ser Leu Gly 175 180 185 ctg acg gga cga tac ctg tat gtg ctc ttt cgg ccc ctg ccc agc aag 688 Leu Thr Gly Arg Tyr Leu Tyr Val Leu Phe Arg Pro Leu Pro Ser Lys 190 195 200 cac ttc gtc atc cac ctc gat gtg tcc tcc aag gac aac caa gtc atc 736 His Phe Val Ile His Leu Asp Val Ser Ser Lys Asp Asn Gln Val Ile 205 210 215 cgt gtg tct ttc tcc aac ctc ttc aag gag ttt aag tct acg gcc acg 784 Arg Val Ser Phe Ser Asn Leu Phe Lys Glu Phe Lys Ser Thr Ala Thr 220 225 230 tgg ctc cag ttt ccc ttg gtc ctg gag gcc agg aca cct cag aga gat 832 Trp Leu Gln Phe Pro Leu Val Leu Glu Ala Arg Thr Pro Gln Arg Asp 235 240 245 250 ctg gtg ggt ttg gcc ccc tcc gga gcc cgc tgg acc tgc ctg cag ctc 880 Leu Val Gly Leu Ala Pro Ser Gly Ala Arg Trp Thr Cys Leu Gln Leu 255 260 265 gat ctg cag gac gtt ctc ctg gtc tac ctg aac cgg tgc tac ggc cat 928 Asp Leu Gln Asp Val Leu Leu Val Tyr Leu Asn Arg Cys Tyr Gly His 270 275 280 ctc aag agc atc agg ctg tgc gcc agc ctg ctg gtc agg aac ctg tac 976 Leu Lys Ser Ile Arg Leu Cys Ala Ser Leu Leu Val Arg Asn Leu Tyr 285 290 295 acc agt gac ctg tgc ttt gag cct gcc atc tct ggg gcc cag tgg gca 1024 Thr Ser Asp Leu Cys Phe Glu Pro Ala Ile Ser Gly Ala Gln Trp Ala 300 305 310 aag ctg ccc gtg act cct atg cct cgg gaa atg gca ttc cct gtg ccc 1072 Lys Leu Pro Val Thr Pro Met Pro Arg Glu Met Ala Phe Pro Val Pro 315 320 325 330 aag gga gag agc tgg cat gac cgc tac atc cac gtc cgg ttt cca agt 1120 Lys Gly Glu Ser Trp His Asp Arg Tyr Ile His Val Arg Phe Pro Ser 335 340 345 gag agc ttg aaa gtg cct tcc aag ccg att gag aag agc tgt tcc cct 1168 Glu Ser Leu Lys Val Pro Ser Lys Pro Ile Glu Lys Ser Cys Ser Pro 350 355 360 cct gag gca gtc ctc ctg ggg ccg ggg cca cag cct ctc cct tgc ccg 1216 Pro Glu Ala Val Leu Leu Gly Pro Gly Pro Gln Pro Leu Pro Cys Pro 365 370 375 gtg gcc tcc agc aaa cct gtg cgg ttc agt gtg tct cca gtg gtc cag 1264 Val Ala Ser Ser Lys Pro Val Arg Phe Ser Val Ser Pro Val Val Gln 380 385 390 acg ccc agc ccc aca gcc cag tcc ggc cgg gcc gcc ttg gca ccc agg 1312 Thr Pro Ser Pro Thr Ala Gln Ser Gly Arg Ala Ala Leu Ala Pro Arg 395 400 405 410 ccc ttc ccg gag gtc agc ctg tcc caa gag cgc tca gac gcc tcc aac 1360 Pro Phe Pro Glu Val Ser Leu Ser Gln Glu Arg Ser Asp Ala Ser Asn 415 420 425 gcg gat ggc ccc ggt ttc cat agc ctt gag ccc tgg gcc cag ctg gag 1408 Ala Asp Gly Pro Gly Phe His Ser Leu Glu Pro Trp Ala Gln Leu Glu 430 435 440 gcc tct gac atc cac acg gct gct gcc ggc acc cac gtg ttg act cac 1456 Ala Ser Asp Ile His Thr Ala Ala Ala Gly Thr His Val Leu Thr His 445 450 455 gag tcg gct gag gtg ccc gtg gcc cgc acc ggc tcc tgc gaa ggc ttc 1504 Glu Ser Ala Glu Val Pro Val Ala Arg Thr Gly Ser Cys Glu Gly Phe 460 465 470 ctc cca gac cca gtc ctg agg ctc aag ggc gtc atc ggc ttt ggg ggc 1552 Leu Pro Asp Pro Val Leu Arg Leu Lys Gly Val Ile Gly Phe Gly Gly 475 480 485 490 cac ggc acc aga cag gcc ctg tgg acc cca gac ggg gcg gct gtc gtg 1600 His Gly Thr Arg Gln Ala Leu Trp Thr Pro Asp Gly Ala Ala Val Val 495 500 505 tac ccc tgc cat gcg gtc atc gtc gtc ctg ctc gtg gac acg ggg gag 1648 Tyr Pro Cys His Ala Val Ile Val Val Leu Leu Val Asp Thr Gly Glu 510 515 520 cag cgc ttc ttc ctt ggc cac aca gac aag gtc tcc gcc ctg gcg ctg 1696 Gln Arg Phe Phe Leu Gly His Thr Asp Lys Val Ser Ala Leu Ala Leu 525 530 535 gat ggc agc agc tca cta ttg gcc tcg gcc cag gca agg gcc cct agt 1744 Asp Gly Ser Ser Ser Leu Leu Ala Ser Ala Gln Ala Arg Ala Pro Ser 540 545 550 gtg atg cgg ctc tgg gac ttc cag acc ggg cgg tgc ttg tgc ctg ttc 1792 Val Met Arg Leu Trp Asp Phe Gln Thr Gly Arg Cys Leu Cys Leu Phe 555 560 565 570 cgg agc cca atg cac gtt gtc tgc tct ctc agc ttc tct gac agc ggg 1840 Arg Ser Pro Met His Val Val Cys Ser Leu Ser Phe Ser Asp Ser Gly 575 580 585 gcc ctt ctc tgc ggg gtt ggc aag gac cac cac ggg agg acg gta aca 1888 Ala Leu Leu Cys Gly Val Gly Lys Asp His His Gly Arg Thr Val Thr 590 595 600 ggg ccc tgg ctg cgg gtt ggg gtg ggg ctg tcc tgatgcacgc agacagctgg 1941 Gly Pro Trp Leu Arg Val Gly Val Gly Leu Ser 605 610 aagggtcttg gttttctgaa actccagctt catgtgaccc tgggtccctg ctctgtgtcc 2001 tccctgtggt ggggctccct gcactctggt gttcatgccg cccccgtgcc ctgcacaaaa 2061 accaccacca gcagctcaca tttcacgtct cggcttttcg gccatcggag tcggtttaag 2121 ccagcgttta cacacctcgc ctcgttctct ctgctggtga tgcggttgta agattttcac 2181 gtggcagagc ccctgcagct gacccacgct tgggcatcaa tggcacctcc acacagccga 2241 agcacccggc atcttggtgg gggcaccttt ttaaacattt tttttttgag agagagcctt 2301 gttctgtcac ctaggctgga atgcagtggt gcaatcatag ctcactgcag ccttgacccc 2361 ctccctgacc tccccgccag ctggactcca gccatcctcc tgcctcagct tcccagatag 2421 ctgggccaca ggcgtgtgcc accacacctg gctaactttt tttttttttt tttttttgag 2481 atggcatctt gctctgtcgc ccaggatgga gtgcagtggc gcgatcttag ctcactgcaa 2541 gctccgcctc ccaggttcac accattctcc tgcctcagcc tccccagtag ctgggactac 2601 aggcgcctgc caacatgcct ggctaatttt ttttttttgt atttttagta gagataggct 2661 ttcaccttgt tagccaggat ggtctcacgt tttgtttttt taactttttg tagagatagg 2721 gtttcattac attgctcagg ctggtctcaa actccagggc tcaagcagtc ctcccacctc 2781 agcctcccaa agtgctggga tcacaggcat gagccactgt gcccagccac gagctgcttt 2841 ttatccacct tccggcttgc gggggggttt gtacttctct gcgaatgggt tgcagtgctc 2901 agcattgcgg gtctctgtag aagtcccaaa gcttcaggat gagaagatgg aggggctggt 2961 ttccttccac tctccacggc cgcacgctca gaggctggtc tccgcatgag agaaaagcca 3021 cctccgggtg gggctcggct gggccttgca gaatcgaggt ggccccgact ggccctgccg 3081 tgcgggctca gcctgggctt gttgcagatg gtggtggcct ggggcaccgg ccaggtgggc 3141 ctcggtggcg aggtggtcgt tctggcaaag gcgcacactg actttgacgt ccaggccttc 3201 cgggtcacct tttttgatga aaccaggatg gcgtcgtgcg ggcagggcag tgtgcggctc 3261 tggcggctgc gtggcggggt gctgcgttcc tgccccgtgg acttagggga gcaccacgcg 3321 ctgcagttca ccgacctggc cttcaagcag gcccgggacg gctgcccgga gccctcggct 3381 gccatgctct tcgtgtgcag ccgcagtggc cacatcttgg agattgactg tcagcgcatg 3441 gtcgtgcggc atgcccgccg cctgctcccc acacggactc caggcggtcc ccacccacag 3501 aagcagacct tcagctcagg ccccggcatt gccatcagca gcctcagcgt ctccccggcc 3561 atgtgtgctg tgggctctga ggacggcttc ttgcggctct ggcccctgga cttctcctcg 3621 gtgctcctgg aggcaggtga tgctgtgggc acgctctccc aactccggga gagcctcgcc 3681 tggatgctgg ggcggggaag gcccagtccc cggggctctg ctgtcagccg ccctggctcc 3741 tggctgcaca gggtgccacg gggccaagtg gcatatccag agccctgggg cggctgatgc 3801 cagggcggcc cgcggggcag cctcacggaa gggcccggtg ggacgtgggt agtgtgtgaa 3861 gcccctcagc ctgggtcccg cctagcctaa gagtggtggc ctcgagggag ctgcatcttg 3921 cagccgtgtg gagcctggga ctttgagcag cagggagtgc atttgctggg gtgtcgggga 3981 cccgaagcct gagcatgcgg ctcaccccgg ggtggccctg gaggcccctg accccacccc 4041 acccacagag cacgagggcc ccgtcagctc agtctgtgtc agccccgatg gcctccgtgt 4101 gctgtctgcc acctcctcgg gccacctggg cttcctggac acgctgtccc gggtgtacca 4161 catgctggct cgctcccaca ccgccccggt gttggccctc gccatggagc agaggcgggg 4221 acagctggcc accgtgtccc aggaccgtac cgtccgcatc tgggacctgg ccaccctgca 4281 gcagctatac gacttcacat catcagagga cgccccgtgc gctgtcacct tccaccccac 4341 aaggccaacc tttttctgtg gctttagcag tggggccgtg cgctccttca gcctggaggc 4401 cgctgaggtc ctggtggaac acacgtgcca ccgaggagct gtcaccggcc tgaccgccac 4461 ccctgacggc cgcctgctct tcagctcctg ctcccagggc tccctggccc agtacagctg 4521 tgcggacccc cagtggcatg tcctccgagt ggcagcggac atggtatgcc cggatgcccc 4581 cgcgagcccc agcgccctgg cagtcagcag ggatggccgc ctgctggcct ttgtgggacc 4641 ctccaggtgc acagtgacag tcatgggctc ggcctccctt gatgagctgc tgcgagttga 4701 catcggcact ctggacctgg ccagcagccg cctggactca gccatggctg tgtgctttgg 4761 ccctgcagct ctgggccacc tgctggtgtc cacctcgtcc aacagagtcg tggtgctgga 4821 tgctgtgtcg ggccgcatca tccgggagct gcccggtgtc caccctgagc cctgcccctc 4881 cttgacgctc agtgaggacg cccgcttcct gctgattgcc gccggccgga ccatcaaggt 4941 gtgggactac gccacacagg ccagcccagg cccccaggtg tacatcggcc actcggaacc 5001 cgtgcaggct gtggccttct ctcctgacca gcagcaggtc ctcagcgcag gggacgccgt 5061 cttcctctgg gatgtcctgg cccctactga gagcgaccaa agcttccccg gggccccccc 5121 agcctgcaag acaggcccgg gcgcaggacc gctggaggac gcagcgtcca gggccagcga 5181 gctcccccgg cagcaggtcc ccaagccatg tcaggcatct ccaccacggc tgggcgtctg 5241 tgccaggcct cccgaaggtg gcgatggcgc cagggacacc aggaattcgg gggccccacg 5301 caccacctac ctggcttcct gcaaggcctt cacgcctgcc agggtcagct gcagccccca 5361 ctctgccaag ggcacttgcc cgcctcccgc cagcggtggg tggctgcgtc tgaaggctgt 5421 cgtcggttac agcgggaatg ggcgggccaa catggtctgg aggccggaca caggcttctt 5481 tgcctacacg tgcggccg 5499 <210> 40 <211> 5497 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (472)..(4266) <400> 40 cagtcaagta gcttcccagt cccgaacgcc gcccgtcccc accccgccgt ggccactagc 60 aacgacctct gtgaagttgg agaggcggta acggaggcac tccccctgct gcaccccgcc 120 gtttctacgg ggctcagaaa ccagtttgtt tgtttcgtcg gggtagtgtc gacctgtctt 180 acgggcgtcg cccgagacag gacggagtca aacccgtggt atcaactgaa gacgagtgtc 240 aggtgtggag agtctcagtg ccccctttca gtctggactg tgagctgctg ctggttagac 300 agtcttggtt tctctttcag gatgtcattt tcaaaatgcg ggatggtacc tctgctttat 360 taagccccgt aggaagactg ccacacctag actgatgctt attagtcatc accgttattc 420 ctactaacgt cctgtgtcac tgagtttttt aaatgtctag catatctgta a aga tgc 477 Arg Cys 1 ctt aga aaa aga atc atg gag aag tat gtt aga cta cag aag att gga 525 Leu Arg Lys Arg Ile Met Glu Lys Tyr Val Arg Leu Gln Lys Ile Gly 5 10 15 gaa ggt tca ttt gga aaa gcc att ctt gtt aaa tct aca gaa gat ggc 573 Glu Gly Ser Phe Gly Lys Ala Ile Leu Val Lys Ser Thr Glu Asp Gly 20 25 30 aga cag tat gtt atc aag gaa att aac atc tca aga atg tcc agt aaa 621 Arg Gln Tyr Val Ile Lys Glu Ile Asn Ile Ser Arg Met Ser Ser Lys 35 40 45 50 gaa aga gaa gaa tca agg aga gaa gtt gca gta ttg gca aac atg aag 669 Glu Arg Glu Glu Ser Arg Arg Glu Val Ala Val Leu Ala Asn Met Lys 55 60 65 cat cca aat att gtc cag tat aga gaa tca ttt gaa gaa aat ggc tct 717 His Pro Asn Ile Val Gln Tyr Arg Glu Ser Phe Glu Glu Asn Gly Ser 70 75 80 ctc tac ata gta atg gat tac tgt gag gga ggg gat ctg ttt aag cga 765 Leu Tyr Ile Val Met Asp Tyr Cys Glu Gly Gly Asp Leu Phe Lys Arg 85 90 95 ata aat gct cag aaa ggc gtt ttg ttt caa gag gat cag att ttg gac 813 Ile Asn Ala Gln Lys Gly Val Leu Phe Gln Glu Asp Gln Ile Leu Asp 100 105 110 tgg ttt gta cag ata tgt ttg gcc ctg aaa cat gta cat gat aga aaa 861 Trp Phe Val Gln Ile Cys Leu Ala Leu Lys His Val His Asp Arg Lys 115 120 125 130 att ctt cat cga gac att aaa tct cag aac ata ttt tta act aaa gat 909 Ile Leu His Arg Asp Ile Lys Ser Gln Asn Ile Phe Leu Thr Lys Asp 135 140 145 gga aca gta caa ctt gga gat ttt gga att gct aga gtt ctt aat agt 957 Gly Thr Val Gln Leu Gly Asp Phe Gly Ile Ala Arg Val Leu Asn Ser 150 155 160 act gta gag ctg gct cga act tgc ata ggg acc cca tac tac ttg tca 1005 Thr Val Glu Leu Ala Arg Thr Cys Ile Gly Thr Pro Tyr Tyr Leu Ser 165 170 175 cct gaa atc tgt gaa aac aaa cct tac aat aat aaa agt gac att tgg 1053 Pro Glu Ile Cys Glu Asn Lys Pro Tyr Asn Asn Lys Ser Asp Ile Trp 180 185 190 gct ctg ggg tgt gtc ctt tat gag ctg tgt aca ctt aaa cat gct ttt 1101 Ala Leu Gly Cys Val Leu Tyr Glu Leu Cys Thr Leu Lys His Ala Phe 195 200 205 210 gaa gct ggc agt atg aaa aac ctg gta ctg aag ata ata tct gga tct 1149 Glu Ala Gly Ser Met Lys Asn Leu Val Leu Lys Ile Ile Ser Gly Ser 215 220 225 ttt cca cct gtg tct ttg cat tat tcc tat gat ctc cgc agt ttg gtg 1197 Phe Pro Pro Val Ser Leu His Tyr Ser Tyr Asp Leu Arg Ser Leu Val 230 235 240 tct cag tta ttt aaa aga aat cct agg gat aga cca tca gtc aac tcc 1245 Ser Gln Leu Phe Lys Arg Asn Pro Arg Asp Arg Pro Ser Val Asn Ser 245 250 255 ata ttg gag aaa ggt ttt ata gcc aaa cgc att gaa aag ttt ctc tct 1293 Ile Leu Glu Lys Gly Phe Ile Ala Lys Arg Ile Glu Lys Phe Leu Ser 260 265 270 cct cag ctt att gca gaa gaa ttt tgt cta aaa aca ttt tcg aag ttt 1341 Pro Gln Leu Ile Ala Glu Glu Phe Cys Leu Lys Thr Phe Ser Lys Phe 275 280 285 290 gga tca cag cct ata cca gct aaa aga cca gct tca gga caa aac tcg 1389 Gly Ser Gln Pro Ile Pro Ala Lys Arg Pro Ala Ser Gly Gln Asn Ser 295 300 305 att tct gtt atg cct gct cag aaa att aca aag cct gcc gct aaa tat 1437 Ile Ser Val Met Pro Ala Gln Lys Ile Thr Lys Pro Ala Ala Lys Tyr 310 315 320 gga ata cct tta gca tat aag aaa tat gga gat aaa aaa tta cac gaa 1485 Gly Ile Pro Leu Ala Tyr Lys Lys Tyr Gly Asp Lys Lys Leu His Glu 325 330 335 aag aaa cca ctg caa aaa cat aaa cag gcc cat caa act cca gag aag 1533 Lys Lys Pro Leu Gln Lys His Lys Gln Ala His Gln Thr Pro Glu Lys 340 345 350 aga gtg aat act gga gaa gaa agg agg aaa ata tct gag gaa gca gca 1581 Arg Val Asn Thr Gly Glu Glu Arg Arg Lys Ile Ser Glu Glu Ala Ala 355 360 365 370 aga aag aga agg ctg gaa ttt att gaa aaa gaa aag aaa caa aag gat 1629 Arg Lys Arg Arg Leu Glu Phe Ile Glu Lys Glu Lys Lys Gln Lys Asp 375 380 385 cag att att agt tta atg aag gct gaa caa atg aaa agg caa gaa aag 1677 Gln Ile Ile Ser Leu Met Lys Ala Glu Gln Met Lys Arg Gln Glu Lys 390 395 400 gaa agg ttg gaa aga ata aat agg gcc agg gaa caa gga tgg aga aat 1725 Glu Arg Leu Glu Arg Ile Asn Arg Ala Arg Glu Gln Gly Trp Arg Asn 405 410 415 gtg cta agt gct ggt gga agt ggt gaa gta aag gct cct ttt ctg ggc 1773 Val Leu Ser Ala Gly Gly Ser Gly Glu Val Lys Ala Pro Phe Leu Gly 420 425 430 agt gga ggg act ata gct cca tca tct ttt tct tct cga gga cag tat 1821 Ser Gly Gly Thr Ile Ala Pro Ser Ser Phe Ser Ser Arg Gly Gln Tyr 435 440 445 450 gaa cat tac cat gcc att ttt gac caa atg cag caa caa aga gca gaa 1869 Glu His Tyr His Ala Ile Phe Asp Gln Met Gln Gln Gln Arg Ala Glu 455 460 465 gat aat gaa gct aaa tgg aaa aga gaa ata tat ggt cga ggt ctt cca 1917 Asp Asn Glu Ala Lys Trp Lys Arg Glu Ile Tyr Gly Arg Gly Leu Pro 470 475 480 gaa aga gga att ctg cct gga gtt cgt cca gga ttt cct tat ggg gct 1965 Glu Arg Gly Ile Leu Pro Gly Val Arg Pro Gly Phe Pro Tyr Gly Ala 485 490 495 gca ggt cat cac cat ttt cct gat gct gat gat att aga aaa act ttg 2013 Ala Gly His His His Phe Pro Asp Ala Asp Asp Ile Arg Lys Thr Leu 500 505 510 aaa aga ttg aag gcg gtg tct aaa caa gcc aat gca aac agg caa aaa 2061 Lys Arg Leu Lys Ala Val Ser Lys Gln Ala Asn Ala Asn Arg Gln Lys 515 520 525 530 ggg cag cta gct gta gaa aga gct aaa caa gta gaa gag ttc ctg cag 2109 Gly Gln Leu Ala Val Glu Arg Ala Lys Gln Val Glu Glu Phe Leu Gln 535 540 545 cga aaa cgg gaa gct atg cag aat aaa gct cga gcc gaa gga cat atg 2157 Arg Lys Arg Glu Ala Met Gln Asn Lys Ala Arg Ala Glu Gly His Met 550 555 560 gtt tat ctg gca aga ctg agg caa ata aga cta cag aat ttc aat gag 2205 Val Tyr Leu Ala Arg Leu Arg Gln Ile Arg Leu Gln Asn Phe Asn Glu 565 570 575 cgc caa cag att aaa gcc aaa ctt cgt ggt gaa aag aaa gaa gct aat 2253 Arg Gln Gln Ile Lys Ala Lys Leu Arg Gly Glu Lys Lys Glu Ala Asn 580 585 590 cat tct gaa gga caa gaa gga agt gaa gag gct gac atg agg cgc aaa 2301 His Ser Glu Gly Gln Glu Gly Ser Glu Glu Ala Asp Met Arg Arg Lys 595 600 605 610 aaa atc gaa tca ctg aag gcc cat gca aat gca cgt gct gct gta cta 2349 Lys Ile Glu Ser Leu Lys Ala His Ala Asn Ala Arg Ala Ala Val Leu 615 620 625 aaa gaa caa cta gaa cga aag aga aag gag gct tat gag aga gaa aaa 2397 Lys Glu Gln Leu Glu Arg Lys Arg Lys Glu Ala Tyr Glu Arg Glu Lys 630 635 640 aaa gtg tgg gaa gag cat ttg gtg gct aaa gga gtt aag agt tct gat 2445 Lys Val Trp Glu Glu His Leu Val Ala Lys Gly Val Lys Ser Ser Asp 645 650 655 gtt tct cca cct ttg gga cag cat gaa aca ggt ggc tct cca tca aag 2493 Val Ser Pro Pro Leu Gly Gln His Glu Thr Gly Gly Ser Pro Ser Lys 660 665 670 caa cag atg aga tct gtt att tct gta act tca gct ttg aaa gaa gtt 2541 Gln Gln Met Arg Ser Val Ile Ser Val Thr Ser Ala Leu Lys Glu Val 675 680 685 690 ggc gtg gac agt agt tta act gat acc cgg gaa act tca gaa gag atg 2589 Gly Val Asp Ser Ser Leu Thr Asp Thr Arg Glu Thr Ser Glu Glu Met 695 700 705 caa aag acc aac aat gct att tca agt aag cga gaa ata ctt cgt aga 2637 Gln Lys Thr Asn Asn Ala Ile Ser Ser Lys Arg Glu Ile Leu Arg Arg 710 715 720 tta aat gaa aat ctt aaa gct caa gaa gat gaa aaa gga aag cag aat 2685 Leu Asn Glu Asn Leu Lys Ala Gln Glu Asp Glu Lys Gly Lys Gln Asn 725 730 735 ctc tct gat act ttt gag ata aat gtt cat gaa gat gcc aaa gag cat 2733 Leu Ser Asp Thr Phe Glu Ile Asn Val His Glu Asp Ala Lys Glu His 740 745 750 gaa aaa gaa aaa tca gtt tca tct gat cgc aag aag tgg gag gca gga 2781 Glu Lys Glu Lys Ser Val Ser Ser Asp Arg Lys Lys Trp Glu Ala Gly 755 760 765 770 ggt caa ctt gtg att cct ctg gat gag tta aca cta gat aca tcc ttc 2829 Gly Gln Leu Val Ile Pro Leu Asp Glu Leu Thr Leu Asp Thr Ser Phe 775 780 785 tct aca act gaa aga cat aca gtg gga gaa gtt att aaa tta ggt cct 2877 Ser Thr Thr Glu Arg His Thr Val Gly Glu Val Ile Lys Leu Gly Pro 790 795 800 aat gga tct cca aga aga gcc tgg ggg aaa agt ccg aca gat tct gtt 2925 Asn Gly Ser Pro Arg Arg Ala Trp Gly Lys Ser Pro Thr Asp Ser Val 805 810 815 cta aag ata ctt gga gaa gct gaa cta caa ctt cag aca gaa cta tta 2973 Leu Lys Ile Leu Gly Glu Ala Glu Leu Gln Leu Gln Thr Glu Leu Leu 820 825 830 gaa aat aca act att aga agt gag att tct ccc gaa ggg gaa aag tac 3021 Glu Asn Thr Thr Ile Arg Ser Glu Ile Ser Pro Glu Gly Glu Lys Tyr 835 840 845 850 aaa ccc tta att act gga gaa aaa aaa gta caa tgt att tca cat gaa 3069 Lys Pro Leu Ile Thr Gly Glu Lys Lys Val Gln Cys Ile Ser His Glu 855 860 865 ata aac cca tca gct att gtt gat tct cct gtt gag aca aaa agt ccc 3117 Ile Asn Pro Ser Ala Ile Val Asp Ser Pro Val Glu Thr Lys Ser Pro 870 875 880 gag ttc agt gag gca tct cca cag atg tca ttg aaa ctg gaa gga aat 3165 Glu Phe Ser Glu Ala Ser Pro Gln Met Ser Leu Lys Leu Glu Gly Asn 885 890 895 tta gaa gaa cct gat gat ttg gaa aca gaa att cta caa gag cca agt 3213 Leu Glu Glu Pro Asp Asp Leu Glu Thr Glu Ile Leu Gln Glu Pro Ser 900 905 910 gga aca aac aaa gat gag agc ttg cca tgc act att act gat gtg tgg 3261 Gly Thr Asn Lys Asp Glu Ser Leu Pro Cys Thr Ile Thr Asp Val Trp 915 920 925 930 att agt gag gaa aaa gaa aca aag gaa act cag tcg gca gat agg atc 3309 Ile Ser Glu Glu Lys Glu Thr Lys Glu Thr Gln Ser Ala Asp Arg Ile 935 940 945 acc att cag gaa aat gaa gtt tct gaa gat gga gtc tcg agt act gtg 3357 Thr Ile Gln Glu Asn Glu Val Ser Glu Asp Gly Val Ser Ser Thr Val 950 955 960 gac caa ctt agt gac att cat ata gag cct gga acc aat gat tct cag 3405 Asp Gln Leu Ser Asp Ile His Ile Glu Pro Gly Thr Asn Asp Ser Gln 965 970 975 cac tct aaa tgt gat gta gat aag tct gtg caa ccg gaa cca ttt ttc 3453 His Ser Lys Cys Asp Val Asp Lys Ser Val Gln Pro Glu Pro Phe Phe 980 985 990 cat aag gtg gtt cat tct gaa cac ttg aac tta gtc cct caa gtt caa 3501 His Lys Val Val His Ser Glu His Leu Asn Leu Val Pro Gln Val Gln 995 1000 1005 1010 tca gtt cag tgt tca cca gaa gaa tcc ttt gca ttt cga tct cac tcg 3549 Ser Val Gln Cys Ser Pro Glu Glu Ser Phe Ala Phe Arg Ser His Ser 1015 1020 1025 cat tta cca cca aaa aat aaa aac aag aat tcc ttg ctg att gga ctt 3597 His Leu Pro Pro Lys Asn Lys Asn Lys Asn Ser Leu Leu Ile Gly Leu 1030 1035 1040 tca act ggt ctg ttt gat gca aac aac cca aag atg tta agg aca tgt 3645 Ser Thr Gly Leu Phe Asp Ala Asn Asn Pro Lys Met Leu Arg Thr Cys 1045 1050 1055 tca ctt cca gat ctc tca aag ctg ttc aga acc ctt atg gat gtt ccc 3693 Ser Leu Pro Asp Leu Ser Lys Leu Phe Arg Thr Leu Met Asp Val Pro 1060 1065 1070 acc gta gga gat gtt cgt caa gac aat ctt gaa ata gat gaa att gaa 3741 Thr Val Gly Asp Val Arg Gln Asp Asn Leu Glu Ile Asp Glu Ile Glu 1075 1080 1085 1090 gat gaa aac att aaa gaa gga cct tct gat tct gaa gac att gtg ttt 3789 Asp Glu Asn Ile Lys Glu Gly Pro Ser Asp Ser Glu Asp Ile Val Phe 1095 1100 1105 gaa gaa act gac aca gat tta caa gag ctg cag gcc tcg atg gaa cag 3837 Glu Glu Thr Asp Thr Asp Leu Gln Glu Leu Gln Ala Ser Met Glu Gln 1110 1115 1120 tta ctt agg gaa caa cct ggt gaa gaa tac agt gaa gaa gaa gag tca 3885 Leu Leu Arg Glu Gln Pro Gly Glu Glu Tyr Ser Glu Glu Glu Glu Ser 1125 1130 1135 gtc ttg aag aac agt gat gtg gag cca act gca aat ggg aca gat gtg 3933 Val Leu Lys Asn Ser Asp Val Glu Pro Thr Ala Asn Gly Thr Asp Val 1140 1145 1150 gca gat gaa gat gac aat ccc agc agt gaa agt gcc ctg aac gaa gaa 3981 Ala Asp Glu Asp Asp Asn Pro Ser Ser Glu Ser Ala Leu Asn Glu Glu 1155 1160 1165 1170 tgg cac tca gat aac agt gat ggt gaa att gct agt gaa tgt gaa tgc 4029 Trp His Ser Asp Asn Ser Asp Gly Glu Ile Ala Ser Glu Cys Glu Cys 1175 1180 1185 gat agt gtc ttt aac cat tta gag gaa ctg aga ctt cat ctg gag cag 4077 Asp Ser Val Phe Asn His Leu Glu Glu Leu Arg Leu His Leu Glu Gln 1190 1195 1200 gaa atg ggc ttt gaa aaa ttc ttt gag gtt tat gag aaa ata aag gct 4125 Glu Met Gly Phe Glu Lys Phe Phe Glu Val Tyr Glu Lys Ile Lys Ala 1205 1210 1215 att cat gaa gat gaa gat gaa aat att gaa att tgt tca aaa ata gtt 4173 Ile His Glu Asp Glu Asp Glu Asn Ile Glu Ile Cys Ser Lys Ile Val 1220 1225 1230 caa aat att ttg gga aat gaa cat cag cat ctt tat gcc aag att ctt 4221 Gln Asn Ile Leu Gly Asn Glu His Gln His Leu Tyr Ala Lys Ile Leu 1235 1240 1245 1250 cat tta gtc atg gca gat gga gcc tac caa gaa gat aat gat gaa 4266 His Leu Val Met Ala Asp Gly Ala Tyr Gln Glu Asp Asn Asp Glu 1255 1260 1265 taatcctcaa aatgtttttt aatcctcaac tatatgaaag catttgaatt tggcttatca 4326 gaataacaag cttcagtggg aaatacagca attatttatt taaaaaatca gatttaagat 4386 ggactttctt attgcatgaa aaagatggag aaacatgcca tttttcaatg aagattctaa 4446 tattttatct attttgttca ttgaattcca tggttaaatc tcataaaata tatactttat 4506 taaatcatcc aaccaaagca taggaaacat tgacccagaa cctgacttaa tggttttgaa 4566 gatttactat gcaatagggt aactttgagt ttcagcaaat gtctttaggt tgaaggaatt 4626 acctatgtca tgaaggacct gtctgtggtt tttcaatgga gtctttaagc atgatctttt 4686 ttctgtctag tacttgtttt cattctggcc agcagttcta cattaaatca ccttgtcaag 4746 ggctctgttt acatctacac attttgaaga tgaaattttt agccttaaag tttatattct 4806 caagtccttt tacaatcagt gtgtctcctg aactagcaca caggctgtag aaacagtctt 4866 agaaatcatt gaaagatttg attatgaaag aatagcaaaa ttatatttct tgacataaaa 4926 agttggttta atgcctttat ttctctttaa ggaccagaac caggaatact gtatcgaaaa 4986 attagtctgt ggatttaaca ctgacttagc atatagctta aagttgctct tttggttttt 5046 aacttcctcc atacataagc ttcaaggaca ataagatgtt aaaaaggagg aaataattat 5106 ttttattttg acactgtgac agttttggta actaggatcc tagggaggga aatgtttgcc 5166 tgttgaactt ctttctgtta tgagaggatt tagttaggtc attaagatgt tgatcacaca 5226 gcttcaatca caatatgcca agtataacct ggtttcgtta gaggtgtcta cagtccagat 5286 gttcttcgta ataaaagcaa agtttttgaa cctctgagtc caaagcaggc tggttggcat 5346 aatatgtaat ttgaaaaata aaatcttatc ttgcagcact atcagtatgt tgaatttatt 5406 atgtatatta tttctaatat ccgaaactaa atacttgatt ttttaatatg tgtgtttatt 5466 ttatgatatt gctattaaat ttttattatc t 5497 <210> 41 <211> 4237 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (2393)..(3271) <400> 41 gcggcactgg ggctgcagcg gcgccgggct ctagagagcc gcaggatcgg ccagagtgcg 60 gactggacac ccgggtccca gatactacag acacccggag aggtggctcc ttcgccctga 120 agccttcctc ggccccctac gcactcgggc cccttccgca gaggattcgc agcgtgagcg 180 ccccgcagcc cgctcaggac cagctcacag gactaaggac caaaggcatt tctgggcact 240 gagatcctac ctctctgcct gcagctatga gcagacgtgt ggttcggcaa agcaagttcc 300 gccatgtgtt tgggcaggca gcaaaggccg accaggccta cgaggacatc cgtgtgtcca 360 aggtcacatg ggacagctcc ttctgtgccg tcaaccccaa attcctggcc attattgtgg 420 aggctggagg cgggggtgcc ttcatcgtcc tgcctctggc caaggtgtgg cagattccag 480 actatacccc catgcgcaac attacggaac ctatcatcac acttgagggc cactccaagc 540 gtgtgggcat cctctcctgg caccctactg ccaggaatgt cctgctcagt gcaggtctgg 600 gggctaagga ggggtccccc atagatgggt gggtggtggc aaaggtggga cccaggtgac 660 catgcctggc cactctgggc aggtggtgac aatgtgatca tcatctggaa tgtgggcacc 720 ggggaggtgc tgctgagcct ggatgatatg cacccagacg tcatccacag tgtgtgctgg 780 aacagcaacg gtagcctgct agccaccacc tgcaaggaca agaccttgcg catcattgac 840 cccagaaaag gccaagtggt ggcggtgagt gcctggcctg gccactcccc agaacccctt 900 gaccagtggc cagctgtcag cacccttgta cccaccatta tcagagcccc tggtcccggc 960 tttcacctgt cgcatccctg ctccagagac tagccccctt cccccgtctc tgcaaccaca 1020 ggtctctgcc ctaagtaagc ccccagcctg caattctctg cccggctcct gttccctccc 1080 ctcccttgca tctcagaagc tcagagaagg gctcctcgct ttgggattga ggaggggaga 1140 agctggaaac tccatcctcc caccagaacc tgcatgaaac ctgagctcct ggacccctct 1200 cctctcagcc ggcacccaga cgcatcttcc agggtctggg gcctgacact ggctcgaggg 1260 ctggcccttt ctccttgtgg acccgctggg cgggggatgg ggcaaccctc gcgcgttgct 1320 tatcccagcc ggatgccctg ggagggcggc ggccctggcc tcgccagcct caagtctaac 1380 ctggggtgcg ggtgcgtggg ccgcgtgcat gtctgcgtgg agcaagcgcg ccgagagcgg 1440 tcggggctgg cgccggggcg ctctaaccca ctaacccggc gagcaggagc aagcccggcc 1500 tcacgagggc gcccgcccgc tgcgggctgt cttcaccgca gacgggaagc tgctcagcac 1560 cggcttcagc aggatgagtg agcggcaact cgcgctctgg gacccggtag gccaggccgc 1620 gccgggcgcg ctagctcgct ccttctctgg gtctgccggg agcgccttcc cgggctgtgg 1680 ctggcgccca agaggccaga gcggagcggg gagctcccat tcgggaaaag cctcgctgcg 1740 actccgggga gccagcagac acccctgctc tagggatcgg cctttgagcg cgcttaaggg 1800 ttcgggatcg gctgagagcc gcgtgcctcc tgctctctcc aggcccggat gctctccagg 1860 tcaggggcca gacgtggccc cgcaggaagc tgagtgctta ggccccattt gtctcttccc 1920 cgcatccgct cctccacccc ggacacccaa gtcagcaagc tggttgctca tccctccatg 1980 ctcctcaggg caggcagctg ggtgatgtcc ctccctgtct ccccctcccc ccaggagagg 2040 tttgcggccc acgaggggat gaggcccatg cgggccgtct tcacgcgcca gggccatatc 2100 ttcaccacgg gcttcacccg catgagccag cgagagctgg gcctgtggga cccggtaacg 2160 cagctggagg cttggggtgt gtgcctcggg gactggcatc acgggagagt ggccaggcgc 2220 cccccacccg cagggcatgc ccacctggac aggactgaag gctgctgcca cctctgcagc 2280 gcctgccatt ctcacaccca cccctctgcc cagttttgct gcgtcgcgtg aaggatcctg 2340 cgctggcgcc cccacctggt gatgccgagt ccctgggggt ggtttgctgt ga ctg cat 2398 Leu His 1 gcg gcg cgc agc ggg tat atg tgc agg gga gga gga gct atg tgc gca 2446 Ala Ala Arg Ser Gly Tyr Met Cys Arg Gly Gly Gly Ala Met Cys Ala 5 10 15 ggg gag gag gag aga tgt gcc cag ggg agg ggc ctg caa ctc tgg tca 2494 Gly Glu Glu Glu Arg Cys Ala Gln Gly Arg Gly Leu Gln Leu Trp Ser 20 25 30 cta gag gtt tgg ggc ata ggg ttt ggg aag gcc agg aag cgt aaa ggg 2542 Leu Glu Val Trp Gly Ile Gly Phe Gly Lys Ala Arg Lys Arg Lys Gly 35 40 45 50 gct tct ggg ggt ccc gaa gta gca cgg gag ggt ggg gca ggg ctg gtc 2590 Ala Ser Gly Gly Pro Glu Val Ala Arg Glu Gly Gly Ala Gly Leu Val 55 60 65 acg cct cct gtg ctc ggg cag aac aac ttc gag gag cca gtg gca ctg 2638 Thr Pro Pro Val Leu Gly Gln Asn Asn Phe Glu Glu Pro Val Ala Leu 70 75 80 cag gag atg gac aca agc aac ggg gtc cta ttg ccc ttt tac gat ccc 2686 Gln Glu Met Asp Thr Ser Asn Gly Val Leu Leu Pro Phe Tyr Asp Pro 85 90 95 gac tcc agc atc gtc tac ctg tgt ggc aag ggc gac agc agc att cgg 2734 Asp Ser Ser Ile Val Tyr Leu Cys Gly Lys Gly Asp Ser Ser Ile Arg 100 105 110 tac ttt gag att acc gac gag ccg cct ttc gtg cac tac ctg aac acg 2782 Tyr Phe Glu Ile Thr Asp Glu Pro Pro Phe Val His Tyr Leu Asn Thr 115 120 125 130 ttc agc agc aaa gag ccg cag cgg ggc atg ggt ttc atg ccc aaa agg 2830 Phe Ser Ser Lys Glu Pro Gln Arg Gly Met Gly Phe Met Pro Lys Arg 135 140 145 gga ctg gat gtc agc aag tgt gag atc gcc cgg ttc tac aag cta cac 2878 Gly Leu Asp Val Ser Lys Cys Glu Ile Ala Arg Phe Tyr Lys Leu His 150 155 160 gaa aga aag tgt gaa cct atc atc atg act gtg ccc cgc aag tca gac 2926 Glu Arg Lys Cys Glu Pro Ile Ile Met Thr Val Pro Arg Lys Ser Asp 165 170 175 ctc ttc cag gac gat ctg tac ccg gat acg cca ggc ccg gag ccg gcc 2974 Leu Phe Gln Asp Asp Leu Tyr Pro Asp Thr Pro Gly Pro Glu Pro Ala 180 185 190 cta gaa gcg gac gaa tgg cta tcc ggc cag gac gcc gaa ccc gtg ctc 3022 Leu Glu Ala Asp Glu Trp Leu Ser Gly Gln Asp Ala Glu Pro Val Leu 195 200 205 210 att tcg ctg agg gac ggc tat gtg ccc ccc aag cac cgc gag ctc cgg 3070 Ile Ser Leu Arg Asp Gly Tyr Val Pro Pro Lys His Arg Glu Leu Arg 215 220 225 gtc acg aag cgc aac atc ctg gac gtg cgc ccg ccc tcc ggc ccc cgc 3118 Val Thr Lys Arg Asn Ile Leu Asp Val Arg Pro Pro Ser Gly Pro Arg 230 235 240 cgc agc cag tcg gcc agc gac gcc ccc ttg tcg cag cac acc ctg gag 3166 Arg Ser Gln Ser Ala Ser Asp Ala Pro Leu Ser Gln His Thr Leu Glu 245 250 255 acg ctg ctg gaa gag atc aag gcc ctc cgc gag cgg gtg cag gcc cag 3214 Thr Leu Leu Glu Glu Ile Lys Ala Leu Arg Glu Arg Val Gln Ala Gln 260 265 270 gag cag cgc atc acg gct ctg gag aac atg ctg tgc gag ctg gtg gac 3262 Glu Gln Arg Ile Thr Ala Leu Glu Asn Met Leu Cys Glu Leu Val Asp 275 280 285 290 ggc acg gac tagccccgcg cgccaggcag gcggagcggg gcggggcgca 3311 Gly Thr Asp caagctcggc cccgccccgg cttttagtcc cgaactccgg accccgcctt cttgggctgg 3371 gcccgggggc gggactgggg agggaactcc gcccctcgcg ggagaccaga actcttggag 3431 cttaggggag acccacgtcg ctccagcgga ggctggactg cgagcctcgt ctgggactcg 3491 gctggagctg gcctagggag gcctggggta acctgggggg ctcagcaatg gtgctgcacg 3551 gcgaggtggt gtcccccttt gtcctccgcc cagggcaggg aaagtgctta gtattagcgt 3611 gatgcttggg gttattggag cctgagcttg acctcaaacg ggtggcgatt tgatgggtac 3671 ccccaggctg gggaaaatga cagcgcttct cctaatcagc tcactggatt ccatcaccct 3731 gagcggtaaa ccagatgggc gtcaccccag ttctgcagac acatacacaa cccgtttgct 3791 gcagagccgg acccagtggc tacacccaca gcggtctgtg gtagagaact ctcttccttc 3851 tttccaccga caggggcgag ggctgcttcc tcgcggcagc ccccgcgaag aaatctcgag 3911 agaactggca tgaggagtta ggttcatcac aaatacacac acactgcccc caaccctctg 3971 ccgttgcctc tctcagaaaa acaagacgta ctgaatgaaa tattttacta agcgttcagt 4031 ctgtgcctcc tgcatgggtg ggagtgaggg gaacgagacc cccagcctct gcaaatgcta 4091 cccccaggct cctgggagac ctggcgatgc actcctgggc tcagggtcca tcaggcagcc 4151 tcttacccta gagctctctc cactctgagg ttcagaagga ccccaaccca caccgtaggc 4211 gttcccccca agtaaagtta ggtagc 4237 <210> 42 <211> 4118 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (597)..(3377) <400> 42 aaaccccgtc tctacttaaa atacaaaaat tagccagatg tggtggcgtg tgactgtaat 60 cccagctact ggggaggcag aggcaggaaa attgcttgaa aacgggaggt ggaagttgca 120 gtgagccgag atcacactac tgcactccag cctgggcaac agagtgagac tacatctcaa 180 aaaaaaaaaa aaaaaaggcc aggcacggtg gctcacacct gtaatcccag cactttggga 240 ggccgaggca ggtagatcac ctgaggtcag gagttcaaga ccagcctggc caacatagtg 300 aaaccccatc tttattaaga atacaaagat tagccgggta tgatgccatg cgcctgtagt 360 cccagctact agggaggctg aggcaggaga atcgcttaaa cccgggaggt ggaggttgca 420 gtgagccaag atagcgccgc tgcactcccg cctgggtgaa agagtgagac tctaaaaaaa 480 aaaaaaatag gaaaccaaag cccagtccgg acacgacgct cacgcctgta atcccagcta 540 ctcgggaggc ggaggcagga aaatcgcttg aacctgggat gaggaggttg cagtga gcc 599 Ala 1 aag atc ata cca ctg cac tcc agc ctg ggc aac aga ggg aga ctc tgt 647 Lys Ile Ile Pro Leu His Ser Ser Leu Gly Asn Arg Gly Arg Leu Cys 5 10 15 ctc aaa aat aaa aaa tat aat aaa aaa caa agc cca gag agg tgc agg 695 Leu Lys Asn Lys Lys Tyr Asn Lys Lys Gln Ser Pro Glu Arg Cys Arg 20 25 30 cac tta ccc aag gtc acg cgg caa gtg act gaa agg ggt agg aca ggg 743 His Leu Pro Lys Val Thr Arg Gln Val Thr Glu Arg Gly Arg Thr Gly 35 40 45 acc caa ggg tgc tca ctc cct gag tcc gtg ctg tgg tcc ctc aag cct 791 Thr Gln Gly Cys Ser Leu Pro Glu Ser Val Leu Trp Ser Leu Lys Pro 50 55 60 65 gcc cct gga ggc agg ttg gag gcc agg att cac ggc aca gtt tct gcc 839 Ala Pro Gly Gly Arg Leu Glu Ala Arg Ile His Gly Thr Val Ser Ala 70 75 80 ccc gtt gta cca cag agt gct atg cag gtt att ggg atc ccg ccc agc 887 Pro Val Val Pro Gln Ser Ala Met Gln Val Ile Gly Ile Pro Pro Ser 85 90 95 atc cag cag ctg gtc ctg cag ctc gtg gcg ggg atc ttg cac ctg ggg 935 Ile Gln Gln Leu Val Leu Gln Leu Val Ala Gly Ile Leu His Leu Gly 100 105 110 aac atc agt ttc tgt gaa gac ggg aat tac gcc cga gtg gag agt gtg 983 Asn Ile Ser Phe Cys Glu Asp Gly Asn Tyr Ala Arg Val Glu Ser Val 115 120 125 gac ctc ctg gcc ttt ccc gcc tac ctg ctg ggc att gac agc ggg cga 1031 Asp Leu Leu Ala Phe Pro Ala Tyr Leu Leu Gly Ile Asp Ser Gly Arg 130 135 140 145 ctg cag gag aag ctg acc agc cgc aag atg gac agc cgc tgg ggc ggg 1079 Leu Gln Glu Lys Leu Thr Ser Arg Lys Met Asp Ser Arg Trp Gly Gly 150 155 160 cgc agc gag tcc atc aat gtg acc ctc aac gtg gag cag gca gcc tac 1127 Arg Ser Glu Ser Ile Asn Val Thr Leu Asn Val Glu Gln Ala Ala Tyr 165 170 175 acc cgt gat gcc ctg gcc aag ggg ctc tat gcc cgc ctc ttc gac ttc 1175 Thr Arg Asp Ala Leu Ala Lys Gly Leu Tyr Ala Arg Leu Phe Asp Phe 180 185 190 ctc gtg gag gcc atc aac cgt gct atg cag aaa ccc cag gaa gag tac 1223 Leu Val Glu Ala Ile Asn Arg Ala Met Gln Lys Pro Gln Glu Glu Tyr 195 200 205 agc atc ggt gtg ctg gac att tac ggc ttc gag atc ttc cag aaa aat 1271 Ser Ile Gly Val Leu Asp Ile Tyr Gly Phe Glu Ile Phe Gln Lys Asn 210 215 220 225 ggc ttc gag cag ttt tgc atc aac ttc gtc aat gag aag ctg cag caa 1319 Gly Phe Glu Gln Phe Cys Ile Asn Phe Val Asn Glu Lys Leu Gln Gln 230 235 240 atc ttt atc gaa ctt acc ctg aag gcc gag cag gag gag tat gtg cag 1367 Ile Phe Ile Glu Leu Thr Leu Lys Ala Glu Gln Glu Glu Tyr Val Gln 245 250 255 gca ggc atc cgc tgg act cca atc cag tac ttc aac aac aag gtc gtc 1415 Ala Gly Ile Arg Trp Thr Pro Ile Gln Tyr Phe Asn Asn Lys Val Val 260 265 270 tgt gac ctc atc gaa aac aag ctg agc ccc cca ggc atc atg agc gtc 1463 Cys Asp Leu Ile Glu Asn Lys Leu Ser Pro Pro Gly Ile Met Ser Val 275 280 285 ttg gac gac gtg tgc gcc acc atg cac gcc acg ggc ggg gga gca gac 1511 Leu Asp Asp Val Cys Ala Thr Met His Ala Thr Gly Gly Gly Ala Asp 290 295 300 305 cag aca ctg ctg cag aag ctg cag gcg gct gtg ggg acc cac gag cat 1559 Gln Thr Leu Leu Gln Lys Leu Gln Ala Ala Val Gly Thr His Glu His 310 315 320 ttc aac agc tgg agc gcc ggc ttc gtc atc cac cac tac gct ggc aag 1607 Phe Asn Ser Trp Ser Ala Gly Phe Val Ile His His Tyr Ala Gly Lys 325 330 335 gtc tcc tac gac gtc agc ggc ttc tgc gag agg aac cga gac gtt ctc 1655 Val Ser Tyr Asp Val Ser Gly Phe Cys Glu Arg Asn Arg Asp Val Leu 340 345 350 ttc tcc gac ctc ata gag ctg atg cag acc agt gag cag gcc ttc ctc 1703 Phe Ser Asp Leu Ile Glu Leu Met Gln Thr Ser Glu Gln Ala Phe Leu 355 360 365 cgg atg ctc ttc ccc gag aag ctg gat gga gac aag aag ggg cgc ccc 1751 Arg Met Leu Phe Pro Glu Lys Leu Asp Gly Asp Lys Lys Gly Arg Pro 370 375 380 385 agc acc gcc ggc tcc aag atc aag aaa caa gcc aac gac ctg gtg gcc 1799 Ser Thr Ala Gly Ser Lys Ile Lys Lys Gln Ala Asn Asp Leu Val Ala 390 395 400 aca ctg atg agg tgc aca ccc cac tac atc cgc tgc atc aaa ccc aac 1847 Thr Leu Met Arg Cys Thr Pro His Tyr Ile Arg Cys Ile Lys Pro Asn 405 410 415 gag acc aag agg ccc cga gac tgg gag gag aac aga gtc aag cac cag 1895 Glu Thr Lys Arg Pro Arg Asp Trp Glu Glu Asn Arg Val Lys His Gln 420 425 430 gtg gaa tac ctg ggc ctg aag gag aac atc agg gtg cgc aga gcc ggc 1943 Val Glu Tyr Leu Gly Leu Lys Glu Asn Ile Arg Val Arg Arg Ala Gly 435 440 445 ttc gcc tac cgc cgc cag ttc gcc aaa ttc ctg cag agg tat gcc att 1991 Phe Ala Tyr Arg Arg Gln Phe Ala Lys Phe Leu Gln Arg Tyr Ala Ile 450 455 460 465 ctg acc ccc gag acg tgg ccg cgg tgg cgt ggg gac gaa cgc cag ggc 2039 Leu Thr Pro Glu Thr Trp Pro Arg Trp Arg Gly Asp Glu Arg Gln Gly 470 475 480 gtc cag cac ctg ctt cgg gcg gtc aac atg gag ccc gac cag tac cag 2087 Val Gln His Leu Leu Arg Ala Val Asn Met Glu Pro Asp Gln Tyr Gln 485 490 495 atg ggg agc acc aag gtc ttt gtc aag aac cca gag tcg ctt ttc ctc 2135 Met Gly Ser Thr Lys Val Phe Val Lys Asn Pro Glu Ser Leu Phe Leu 500 505 510 ctg gag gag gtg cga gag cga aag ttc gat ggc ttt gcc cga acc atc 2183 Leu Glu Glu Val Arg Glu Arg Lys Phe Asp Gly Phe Ala Arg Thr Ile 515 520 525 cag aag gcc tgg cgg cgc cac gtg gct gtc cgg aag tac gag gag atg 2231 Gln Lys Ala Trp Arg Arg His Val Ala Val Arg Lys Tyr Glu Glu Met 530 535 540 545 cgg gag gaa gct tcc aac atc ctg ctg aac aag aag gag cgg agg cgc 2279 Arg Glu Glu Ala Ser Asn Ile Leu Leu Asn Lys Lys Glu Arg Arg Arg 550 555 560 aac agc atc aat cgg aac ttc gtc ggg gac tac ctg ggg ctg gag gag 2327 Asn Ser Ile Asn Arg Asn Phe Val Gly Asp Tyr Leu Gly Leu Glu Glu 565 570 575 cgg ccc gag ctg cgt cag ttc ctg ggc aag agg gag cgg gtg gac ttc 2375 Arg Pro Glu Leu Arg Gln Phe Leu Gly Lys Arg Glu Arg Val Asp Phe 580 585 590 gcc gat tcg gtc acc aag tac gac cgc cgc ttc aag ccc atc aag cgg 2423 Ala Asp Ser Val Thr Lys Tyr Asp Arg Arg Phe Lys Pro Ile Lys Arg 595 600 605 gac ttg atc ctg acg ccc aag tgt gtg tat gtg att ggg cga gag aaa 2471 Asp Leu Ile Leu Thr Pro Lys Cys Val Tyr Val Ile Gly Arg Glu Lys 610 615 620 625 gtg aag aag gga cct gag aag ggc cag gtg tgt gaa gtc ttg aag aag 2519 Val Lys Lys Gly Pro Glu Lys Gly Gln Val Cys Glu Val Leu Lys Lys 630 635 640 aaa gtg gac atc cag gct ctg cgg gga gtc tcc ctc agc acg cga cag 2567 Lys Val Asp Ile Gln Ala Leu Arg Gly Val Ser Leu Ser Thr Arg Gln 645 650 655 gac gac ttc ttc atc ctc caa gag gat gcc gcc gac agc ttc ctg gag 2615 Asp Asp Phe Phe Ile Leu Gln Glu Asp Ala Ala Asp Ser Phe Leu Glu 660 665 670 agc gtc ttc aag acc gag ttt gtc agc ctt ctg tgc aag cgc ttc gag 2663 Ser Val Phe Lys Thr Glu Phe Val Ser Leu Leu Cys Lys Arg Phe Glu 675 680 685 gag gcg acg cgg agg ccc ctg ccc ctc acc ttc agc gac aca cta cag 2711 Glu Ala Thr Arg Arg Pro Leu Pro Leu Thr Phe Ser Asp Thr Leu Gln 690 695 700 705 ttt cgg gtg aag aag gag ggc tgg ggc ggt ggc ggc acc cgc agc gtc 2759 Phe Arg Val Lys Lys Glu Gly Trp Gly Gly Gly Gly Thr Arg Ser Val 710 715 720 acc ttc tcc cgc ggc ttc ggc gac ttg gca gtg ctc aag gtt ggc ggt 2807 Thr Phe Ser Arg Gly Phe Gly Asp Leu Ala Val Leu Lys Val Gly Gly 725 730 735 cgg acc ctc acg gtc agc gtg ggc gat ggg ctg ccc aag agc tcc aag 2855 Arg Thr Leu Thr Val Ser Val Gly Asp Gly Leu Pro Lys Ser Ser Lys 740 745 750 cct acg cgg aag gga atg gcc aag gga aaa cct cgg agg tcg tcc caa 2903 Pro Thr Arg Lys Gly Met Ala Lys Gly Lys Pro Arg Arg Ser Ser Gln 755 760 765 gcc cct acc cgg gcg gcc cct gcg ccc ccc aga ggc atg gat cgc aat 2951 Ala Pro Thr Arg Ala Ala Pro Ala Pro Pro Arg Gly Met Asp Arg Asn 770 775 780 785 ggg gtg ccc ccc tct gcc aga ggg ggc ccc ctg ccc ctg gag atc atg 2999 Gly Val Pro Pro Ser Ala Arg Gly Gly Pro Leu Pro Leu Glu Ile Met 790 795 800 tct gga ggg ggc acc cac agg cct ccc cgg ggc cct ccg tcc aca tcc 3047 Ser Gly Gly Gly Thr His Arg Pro Pro Arg Gly Pro Pro Ser Thr Ser 805 810 815 ctg gga gcc agc aga cga ccc cgg gca cgt ccg ccc tca gag cac aac 3095 Leu Gly Ala Ser Arg Arg Pro Arg Ala Arg Pro Pro Ser Glu His Asn 820 825 830 aca gaa ttc ctc aac gtg cct gac cag ggc atg gcc ggc atg cag agg 3143 Thr Glu Phe Leu Asn Val Pro Asp Gln Gly Met Ala Gly Met Gln Arg 835 840 845 aag cgc agc gtg ggg caa cgg cca gtg cct ggt gtg ggc cga ccc aag 3191 Lys Arg Ser Val Gly Gln Arg Pro Val Pro Gly Val Gly Arg Pro Lys 850 855 860 865 ccc cag cct cgg aca cat ggt ccc agg tgc cgg gcc cta tac cag tac 3239 Pro Gln Pro Arg Thr His Gly Pro Arg Cys Arg Ala Leu Tyr Gln Tyr 870 875 880 gtg ggc caa gat gtg gac gag ctg agc ttc aac gtg aac gag gtc att 3287 Val Gly Gln Asp Val Asp Glu Leu Ser Phe Asn Val Asn Glu Val Ile 885 890 895 gag atc ctc atg gaa gat ccc tcg ggc tgg tgg aag ggc cgg ctt cac 3335 Glu Ile Leu Met Glu Asp Pro Ser Gly Trp Trp Lys Gly Arg Leu His 900 905 910 ggc cag gag ggc ctt ttc cca gga aac tac gtg gag aag atc 3377 Gly Gln Glu Gly Leu Phe Pro Gly Asn Tyr Val Glu Lys Ile 915 920 925 tgagctgggc cctgggatac tgccttctct ttcgcccgcc tatctgcctg ccggcctggt 3437 ggggagccag gccctgccaa tgagagcctc gtttacctgg gctgcaatag cctaaaagtc 3497 cagtcctttg gcctccagtc ctgcccaggc cctgggtcac caggtcactg ctgcagcccc 3557 cgcccctggg ccctggtctt cctccaacat cacacctgct gcccattctc catttctgtg 3617 tgtgtcaaag gggactaaca gcagaatcta cctcccaact gccatgtgat taagaaatgg 3677 gtcttgagtc ctgtgctgtt ggcaaagtgc caggcacagt tggggagggg ggggtcctta 3737 acaagcgtga ctttgctcat tctgtcatca ctaaggcaat aaacctttgc caggtgaaag 3797 cacgagttaa cttactaagt gcccaacaag gacgatgttt tcacagccct gtgaggtagg 3857 agctgtgaag gaccccatct tacaggtgga acaatggagg ttcagagagg ttcactgacc 3917 caagactgca cagagccatg ccttgcattc atatgtgacc ataaagcttg aatttgtccc 3977 agtttgggct gggcgcagtg gctcacgcct gtaatcccag cactttggga ggctgaggcg 4037 ggcagatcac gtgagaccag gagttcaaga ccagcctgga taacacagca aaaccctgtt 4097 tctactaaaa atttaaaaaa g 4118 <210> 43 <211> 4382 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (815)..(3856) <400> 43 caactagagg agctcgcccc ctgcctgtga cagcttaggg tcgcctactt tttgtggaca 60 cactgccgtc cacggagtgc agaggccgcc tgcagttttc ttgcgtccct gtgagacgca 120 cggtggcgca attcccgagc gtgccaatcc cgggctggct ggagggcggg ctcttcaaat 180 ttgaattgcg gaagtgtttt gtgtgttaga gaacgtcgcg gaggaggtaa gcgtcgcttg 240 gcgcctggcc gccgcgggca ggatacaccg tgggcctgag gcgcgagccc ggcggcgtgc 300 ggccctctct ccgcgcggag ccgagccgga actgcggcag tctctccctg ccaggctctt 360 catccaaggt ttctgtggat cccttctgaa gttctatctg aaaattgcgc ttaagtgaat 420 tttctgttag aagaacttgg ttgctacttt cttgtcaaga tgattgcaac acctttgaaa 480 cattcaagaa tttacttacc tccagaggca tcttctcaaa ggagaaatct acccatggat 540 gcaatctttt ttgacagcat tccttcaggc acacttactc ctgtaaaaga tttggtgaaa 600 tatcagaact cctccttaaa attgaatgac cataaaaaga atcagttcct aaaaatgaca 660 acttttaaca ataaaaatat atttcaatca actatgctaa cagaggctac tacctctaac 720 agttctcttg atatcagtgc tataaagccc aacaaggatg gattaaaaaa taaagcaaac 780 tatgaatcac caggaaaaat atttctaaga atga aag aaa aag tac tgc gtg aca 835 Lys Lys Lys Tyr Cys Val Thr 1 5 agc aag aac agc cat caa gaa aca gta gtt tgt tgg aac cac aga aaa 883 Ser Lys Asn Ser His Gln Glu Thr Val Val Cys Trp Asn His Arg Lys 10 15 20 gtg gaa ata atg aaa cct tca ctc cta aca gag ttg aaa aaa aaa aaa 931 Val Glu Ile Met Lys Pro Ser Leu Leu Thr Glu Leu Lys Lys Lys Lys 25 30 35 ttg cag cat acc tac cta tgt gaa gaa aag gaa aac aac aaa tca ttc 979 Leu Gln His Thr Tyr Leu Cys Glu Glu Lys Glu Asn Asn Lys Ser Phe 40 45 50 55 cag tca gat gac agt tca cta aga gcc tca gtc caa gga gtt cct cta 1027 Gln Ser Asp Asp Ser Ser Leu Arg Ala Ser Val Gln Gly Val Pro Leu 60 65 70 gaa tca tca aat aat gat att ttc ctc ccg gtc aaa caa aag att cag 1075 Glu Ser Ser Asn Asn Asp Ile Phe Leu Pro Val Lys Gln Lys Ile Gln 75 80 85 tgc cag cag gaa aag aaa gca cca ctg cac aat tta act tac gaa ctt 1123 Cys Gln Gln Glu Lys Lys Ala Pro Leu His Asn Leu Thr Tyr Glu Leu 90 95 100 cca act ctg aac caa gaa cag gaa aat ttt ttg gct gta gaa gcc cga 1171 Pro Thr Leu Asn Gln Glu Gln Glu Asn Phe Leu Ala Val Glu Ala Arg 105 110 115 aac aag aca tta act aga gct cag ttg gct aaa caa att ttt cac tca 1219 Asn Lys Thr Leu Thr Arg Ala Gln Leu Ala Lys Gln Ile Phe His Ser 120 125 130 135 aag gag agt ata gtt gca acc act aaa tcc aaa aag gac acg ttt gtt 1267 Lys Glu Ser Ile Val Ala Thr Thr Lys Ser Lys Lys Asp Thr Phe Val 140 145 150 tta gaa agc gtt gat tct gct gat gaa caa ttt caa aat act aat gct 1315 Leu Glu Ser Val Asp Ser Ala Asp Glu Gln Phe Gln Asn Thr Asn Ala 155 160 165 gag act ctc agt act aat tgt att cct att aaa aat ggc agc ctg tta 1363 Glu Thr Leu Ser Thr Asn Cys Ile Pro Ile Lys Asn Gly Ser Leu Leu 170 175 180 atg gtt tct gat agt gag agg aca aca gaa ggg act tcg caa cag aaa 1411 Met Val Ser Asp Ser Glu Arg Thr Thr Glu Gly Thr Ser Gln Gln Lys 185 190 195 gtt aag gaa gga aat gga aaa aca gtg cct gga gag aca ggt ctt cca 1459 Val Lys Glu Gly Asn Gly Lys Thr Val Pro Gly Glu Thr Gly Leu Pro 200 205 210 215 ggt tcc atg aaa gat aca tgt aaa att gta ctt gca aca cca aga ctt 1507 Gly Ser Met Lys Asp Thr Cys Lys Ile Val Leu Ala Thr Pro Arg Leu 220 225 230 cat ata aca ata cct cgg agg tca aaa aga aat att tca aag ctt tct 1555 His Ile Thr Ile Pro Arg Arg Ser Lys Arg Asn Ile Ser Lys Leu Ser 235 240 245 cct cca aga ata ttt caa act gtt aca aat gga ctt aaa aaa aat cag 1603 Pro Pro Arg Ile Phe Gln Thr Val Thr Asn Gly Leu Lys Lys Asn Gln 250 255 260 gta gtt cag cta cag gaa tgg atg att aaa agc atc aat aat aat act 1651 Val Val Gln Leu Gln Glu Trp Met Ile Lys Ser Ile Asn Asn Asn Thr 265 270 275 gct ata tgt gta gaa gga aaa ttg ata gac gtc act aac ata tat tgg 1699 Ala Ile Cys Val Glu Gly Lys Leu Ile Asp Val Thr Asn Ile Tyr Trp 280 285 290 295 cac agt aat gta att ata gag cgg att gag cac aac aaa ctt agg act 1747 His Ser Asn Val Ile Ile Glu Arg Ile Glu His Asn Lys Leu Arg Thr 300 305 310 ata tca ggc aac gtt tat ata tta aaa ggc atg ata gac caa att tcc 1795 Ile Ser Gly Asn Val Tyr Ile Leu Lys Gly Met Ile Asp Gln Ile Ser 315 320 325 atg aaa gaa gca gga tat cca aat tat ctc ata agg aaa ttt atg ttt 1843 Met Lys Glu Ala Gly Tyr Pro Asn Tyr Leu Ile Arg Lys Phe Met Phe 330 335 340 gga ttt cca gaa aat tgg aaa gag cac att gat aat ttt ctg gaa caa 1891 Gly Phe Pro Glu Asn Trp Lys Glu His Ile Asp Asn Phe Leu Glu Gln 345 350 355 tta agg gct ggt gaa aag aac agg gaa aag acc aaa caa aaa cag aaa 1939 Leu Arg Ala Gly Glu Lys Asn Arg Glu Lys Thr Lys Gln Lys Gln Lys 360 365 370 375 act gga aga tct gtc cgt gac ata agg aaa tca atg aaa aat gat gca 1987 Thr Gly Arg Ser Val Arg Asp Ile Arg Lys Ser Met Lys Asn Asp Ala 380 385 390 caa gaa aac caa aca gat act gct caa aga gcc acc acc act tac gat 2035 Gln Glu Asn Gln Thr Asp Thr Ala Gln Arg Ala Thr Thr Thr Tyr Asp 395 400 405 ttt gat tgt gat aat ttg gaa ctg aag agt aat aag cac agt gag tca 2083 Phe Asp Cys Asp Asn Leu Glu Leu Lys Ser Asn Lys His Ser Glu Ser 410 415 420 cca gga gct aca gaa tta aac atg tgc cac agt aat tgc caa aat aaa 2131 Pro Gly Ala Thr Glu Leu Asn Met Cys His Ser Asn Cys Gln Asn Lys 425 430 435 cca aca tta agg ttc cca gat gac caa gta aat aat act att caa aat 2179 Pro Thr Leu Arg Phe Pro Asp Asp Gln Val Asn Asn Thr Ile Gln Asn 440 445 450 455 gga gga gga gat gac tta tct aat cag gaa tta att gga aaa aaa gaa 2227 Gly Gly Gly Asp Asp Leu Ser Asn Gln Glu Leu Ile Gly Lys Lys Glu 460 465 470 tat aaa atg tct tca aag aaa cta aaa att ggt gaa aga aca aat gaa 2275 Tyr Lys Met Ser Ser Lys Lys Leu Lys Ile Gly Glu Arg Thr Asn Glu 475 480 485 agg ata ata aaa agt cag aag caa gag aca act gaa gaa ttg gat gta 2323 Arg Ile Ile Lys Ser Gln Lys Gln Glu Thr Thr Glu Glu Leu Asp Val 490 495 500 tcc att gat att cta acc tca agg gaa cag ttt ttc tca gat gaa gaa 2371 Ser Ile Asp Ile Leu Thr Ser Arg Glu Gln Phe Phe Ser Asp Glu Glu 505 510 515 aga aaa tac atg gcc atc aat cag aag aaa gct tat att tta gta aca 2419 Arg Lys Tyr Met Ala Ile Asn Gln Lys Lys Ala Tyr Ile Leu Val Thr 520 525 530 535 cca ctt aaa tct aga aaa gtg ata gag caa aga tgc atg agg tat aat 2467 Pro Leu Lys Ser Arg Lys Val Ile Glu Gln Arg Cys Met Arg Tyr Asn 540 545 550 ctg tcc gct ggc acc atc aaa gca gta aca gat ttt gta ata cca gag 2515 Leu Ser Ala Gly Thr Ile Lys Ala Val Thr Asp Phe Val Ile Pro Glu 555 560 565 tgt caa aaa aaa agt ccc atc agc aag tcc atg ggg act tta gaa aat 2563 Cys Gln Lys Lys Ser Pro Ile Ser Lys Ser Met Gly Thr Leu Glu Asn 570 575 580 aca ttt gaa ggt cat aaa agt aaa aac aag gaa gat tgc gat gaa cgt 2611 Thr Phe Glu Gly His Lys Ser Lys Asn Lys Glu Asp Cys Asp Glu Arg 585 590 595 gac tta ctt act gtc aac cgg aaa ata aaa ata tct aac ctt gaa aag 2659 Asp Leu Leu Thr Val Asn Arg Lys Ile Lys Ile Ser Asn Leu Glu Lys 600 605 610 615 gaa caa atg ctc acc tct gac ttt aag aaa aat acc aga cta tta cca 2707 Glu Gln Met Leu Thr Ser Asp Phe Lys Lys Asn Thr Arg Leu Leu Pro 620 625 630 aaa ttg aag aaa ata gaa aat cag gta gct atg tca ttt tat aag cat 2755 Lys Leu Lys Lys Ile Glu Asn Gln Val Ala Met Ser Phe Tyr Lys His 635 640 645 cag tcc tca cca gat ttg tca agt gaa gaa agt gaa aca gaa aag gaa 2803 Gln Ser Ser Pro Asp Leu Ser Ser Glu Glu Ser Glu Thr Glu Lys Glu 650 655 660 att aaa agg aaa gct gaa gtt aag aaa acc aaa gca gga aac acc aaa 2851 Ile Lys Arg Lys Ala Glu Val Lys Lys Thr Lys Ala Gly Asn Thr Lys 665 670 675 gaa gca gtg gtt cac ctg aga aag agc aca aga aac aca agt aat att 2899 Glu Ala Val Val His Leu Arg Lys Ser Thr Arg Asn Thr Ser Asn Ile 680 685 690 695 cca gtg att ttg gaa cct gaa act gaa gaa agt gaa aat gaa ttt tat 2947 Pro Val Ile Leu Glu Pro Glu Thr Glu Glu Ser Glu Asn Glu Phe Tyr 700 705 710 atc aaa caa aag aaa gct aga cct tcc gtc aaa gaa act ctt cag aag 2995 Ile Lys Gln Lys Lys Ala Arg Pro Ser Val Lys Glu Thr Leu Gln Lys 715 720 725 tct ggt gtt agg aaa gag ttt cca att act gag gca gta gga tct gat 3043 Ser Gly Val Arg Lys Glu Phe Pro Ile Thr Glu Ala Val Gly Ser Asp 730 735 740 aag aca aat agg cat ccc tta gaa tgc tta cct ggt tta att cag gat 3091 Lys Thr Asn Arg His Pro Leu Glu Cys Leu Pro Gly Leu Ile Gln Asp 745 750 755 aag gaa tgg aat gag aag gag tta cag aaa ctt cat tgt gct ttt gca 3139 Lys Glu Trp Asn Glu Lys Glu Leu Gln Lys Leu His Cys Ala Phe Ala 760 765 770 775 tct ctt cca aag cac aaa cct ggt ttc tgg tca gag gta gct gcg gct 3187 Ser Leu Pro Lys His Lys Pro Gly Phe Trp Ser Glu Val Ala Ala Ala 780 785 790 gta ggt tct cga tct cct gaa gaa tgc cag agg aaa tac atg gaa aat 3235 Val Gly Ser Arg Ser Pro Glu Glu Cys Gln Arg Lys Tyr Met Glu Asn 795 800 805 ccc aga gga aaa gga tcc cag aaa cat gtc act aag aag aag cca gcc 3283 Pro Arg Gly Lys Gly Ser Gln Lys His Val Thr Lys Lys Lys Pro Ala 810 815 820 aat tcc aaa ggc caa aat ggc aag aga ggt gat gct gat cag aaa caa 3331 Asn Ser Lys Gly Gln Asn Gly Lys Arg Gly Asp Ala Asp Gln Lys Gln 825 830 835 act att aag ata act gcc aaa gtg gga act ctt aaa agg aag caa cag 3379 Thr Ile Lys Ile Thr Ala Lys Val Gly Thr Leu Lys Arg Lys Gln Gln 840 845 850 855 atg agg gaa ttt ctg gaa cag ttg cca aaa gat gac cat gat gat ttt 3427 Met Arg Glu Phe Leu Glu Gln Leu Pro Lys Asp Asp His Asp Asp Phe 860 865 870 ttc agt aca aca cct tta cag cat caa aga ata ctg ttg cca agt ttc 3475 Phe Ser Thr Thr Pro Leu Gln His Gln Arg Ile Leu Leu Pro Ser Phe 875 880 885 cag gac agt gaa gat gat gat gat att ctg cca aat atg gac aaa aat 3523 Gln Asp Ser Glu Asp Asp Asp Asp Ile Leu Pro Asn Met Asp Lys Asn 890 895 900 cca aca act cca tca tca gtt atc ttt cca ttg gta aaa act cct caa 3571 Pro Thr Thr Pro Ser Ser Val Ile Phe Pro Leu Val Lys Thr Pro Gln 905 910 915 tgt cag cat gtc agt cct ggc atg cta ggt tct ata aat agg aat gac 3619 Cys Gln His Val Ser Pro Gly Met Leu Gly Ser Ile Asn Arg Asn Asp 920 925 930 935 tgt gat aaa tat gtt ttt cgt atg caa aaa tat cat aaa agt aat ggt 3667 Cys Asp Lys Tyr Val Phe Arg Met Gln Lys Tyr His Lys Ser Asn Gly 940 945 950 ggt att gtc tgg ggc aac atc aag aaa aaa tta gtt gaa act gat ttc 3715 Gly Ile Val Trp Gly Asn Ile Lys Lys Lys Leu Val Glu Thr Asp Phe 955 960 965 tca act cca aca cca aga agg aaa acc cca ttt aac aca gac tta gga 3763 Ser Thr Pro Thr Pro Arg Arg Lys Thr Pro Phe Asn Thr Asp Leu Gly 970 975 980 gaa aac tct ggt att gga aaa ctt ttc act aat gct gtg gaa tct tta 3811 Glu Asn Ser Gly Ile Gly Lys Leu Phe Thr Asn Ala Val Glu Ser Leu 985 990 995 gat gaa gaa gag aaa gat tat tat ttt tcg aac tct gat tct gca 3856 Asp Glu Glu Glu Lys Asp Tyr Tyr Phe Ser Asn Ser Asp Ser Ala 1000 1005 1010 tagtaaaatg agaaaatatg attcctggga tttttaccat aaagcagaca gtgtttgtat 3916 tttcaactgg agtacatgta ttttctttgt aaagtagctt cctatgaaaa tgtggacttt 3976 tttgaaggtt tcatatgttt gtgttcaaag taaaatatcc tcattgctgc agcttactaa 4036 aaatgtaaag aaaattgttt ttgctcgtgt agatatctgt aaatttgttt ttgcatatta 4096 aaatatatat agataatttt ttaataagca tccaagtctg tttactttaa gaaaaccatt 4156 tcccaaacag attttttttt tatttcaaga aaattttgct accatttaag taagagaagg 4216 tgagaaggat gacagaggtt gtattggtag ctattgaatt catgaaaact tttaagttag 4276 catttgttag cagttattat ccaagccaga gtaggatttg ttaccagttg ttatccaaac 4336 ctaatgttta aattacacat tgttgaaatt aaattacaca ttgttg 4382 <210> 44 <211> 8262 <212> DNA <213> Homo sapiens <220> <221> CDS <222> (5728)..(5955) <400> 44 gtccttttaa aaaaactcat tttggccagg cgcggtggct cacgcctgta atcccagcac 60 tttgggaggc tgagacgggc ggatcatttg aggtcaggag tttgagacca ccctggccaa 120 catggtaaaa ccctatctct actaaaaata caaaaattag cagagtgtgg tggcacgtgc 180 ctataaaccc agctactcag gaggctgagg cacgagaatc acttgaaccc gggaggtgga 240 ggttgcagtg agccgagatg gtgccactgc actccagcct gggcaacaga gtgagactct 300 gtctcaagaa aagcccccat tttaaccact ctgtctcttc ttccaggcct ttagaggcag 360 aagagaacca ttgtaaattc cagcacaagc tctttcaggc attgtttata gtttaataaa 420 tcctgccacc tctattcatc ccggtaatga aggggcgact gctcaggaga aaagccaggg 480 tgcacaaaga gatgggcatt agcatataaa aggacagagg tgggccttcc accctttgca 540 acgatgctcc ttgtacatcc acagagaatt cccttctgat cagtgcacag tgagtaaagg 600 cgccggctcc aaagatgcct gctcagagtg gctgggcgtg tctgccccag gctgtcctgt 660 tgtttcgggt tcatcatggt gggaggtggt gtcagggatc agaacaggca gagatgcctg 720 gggatggatg ccacagcctc aggaagggac catcgtcatg tatttaataa cttgaaacag 780 attaagacca cgagtgtgcg tgcacacaca cacacttgcg cttgcatacg tgcactcaca 840 gaactgtgct ttgctcagca ctttcccagc tgaatggccc tcttcaggtg cctgaaggcc 900 tctggaacac acacttgtct gtctgtcgac cacctgttca tgcacgatgc tttgagtgcc 960 tctgaacatt cggactccat gtgttctagt tctgcatgct ggacataaca gactgacaag 1020 caccatcccc tgctctggag gagccttcca ttgagagggg tcagggagta gacatacctc 1080 caccagagtc cgcgaaagcg ctcggcaggg agagctgggg agaggggctc ccctgtctgg 1140 ccacgggcag tgtctagtca cctggcttgt tttcttcttt ggcaaaccag cagcagagac 1200 cttgtgggca gaagtctcca ctctggccgg acccttgact ggggtagcca cccatccatg 1260 gcaccactgt cgaggggaga ggagccgttg cccccagggc tcttccctcc ctctctgccg 1320 gcatcattgg gtagaaagca ggcatccttg acactgctag ccatcaggag agccagtgtt 1380 accaaaggcc atcaggagag ccggtgtcac caaaggaagt catgtttctt tctctgaagt 1440 ccgtgtgtca gtcccacagg atgtgagacg tcagaagatg aagatagctc ttctggtggg 1500 gactttgatg ttacgacttg cagcaccaca gagcacctgc ttttcatata agttctttct 1560 gtggacctga aataatccaa aatcatctca tcaagtggaa tatgccatat gatatttaaa 1620 tacctgtaat ttctctaaaa ccctggggcc agaaactcta gtggttgctc tattcatgga 1680 ttcatgttgc agtaaaatgt gataattgat gaatatctgt ggaaatggat atgattgtgt 1740 ccttttaaat gagctaacaa tttcacgccg aaatctcagc agtgctattg tttagaataa 1800 aaggagacat gcaaatgagg ccagggtgca gattgtggta gaacaatgct ggcagcctct 1860 ttattggacc cattaattaa ttccccatca gccagtttcc ctgggaatga actggaaaaa 1920 taattaaaat gatacatgag gtaaggagtt tagaaattca aaaggtgaag gcgagaatta 1980 gtttaatacg taattagaca tattatttgt gactctacgt ttttttaaat gtggctcact 2040 gaggcagtag ggtcctattt ttagtcctgg atagttaata aatatcactt ggggctgttt 2100 ttcaacccac aatggctcat aaattttctt aataacatta agtggctaat tatattgtac 2160 attgttaaaa taacttctat tgcaaaatct aataatacca caaaagtttg caaaagcaag 2220 tttttagagg aattcatttg actcaatttc caagtgagat ctggcacacg tagaccaaac 2280 tgaaaaatgt atagcaaaga atctgcaggt tcacatatat ttttgttgca aacatgatcc 2340 aaacaatctc aaaacccaac ttcgttttag tgtgagtggt gcagatggaa cgtcgtacct 2400 cccagagttc agactgagtg ctggctccat ggctcttggg agtggcggaa tcttaacgga 2460 acgtgcttcc actgctgtgt cctctcggtg aggcctcggc cctagcctca gtgttgcata 2520 tgtcaggatg gacgaacgtg agtcttggca tggtgcaagt gcatctgaat tgcatgtctc 2580 tgtccttgct ggagcaaaac cctgttgttt ggatggagcg gagctgacct gacggttcca 2640 ggctgttccc tgttgtttgg ttggacgctg ttccctgttt ggatggagtg gagctgactt 2700 gacggttccc ggctgttccc tgttgtttgg ttggagcggg gctgacctga cggtcctggc 2760 tgttcccggt tgtttggttg gagcggagct gacctgacgg tcctggctgt tccctattgt 2820 ttggttggag cagagctgac ttgacggttc ccggctgttc cctgttgttt ggttggagcg 2880 gggctgacct gacggttcca ggctgttccc tgttgtttgg ttggagcgga gctgacttga 2940 cggttccagc gctgtcccct gttgtttggt tggagcagag ctgacctgac ggtcccagcg 3000 ctgtcccctg tttggttgga gcggagctga cctgacggtc ccagcgctgt cccctgttgt 3060 ttggttggag cggagctgac ctgatggttc caggctgttc cctgttgttt ggttggacgc 3120 tgtcccctgt tgtttggttg gagcggagct gacttgatgg ttcgagactg ttccctgttg 3180 tttggttgga gcagggctga cctgacggtc ctggctgttc cctgttgttt ggttggacgc 3240 tgtcccctgt tgtttggttg gagcggagct gacctgacgg ttccaggctg ttccctgttg 3300 tttggttgga cgctgtcccc tgttgtttgg ttggagcgga gctgacttga tggttccagg 3360 ctgttccctg ttgtttggtt ggagcggggc tgacctgacg gtcctggctg ttccctgttg 3420 tttggttgga gcggagctga cctgacggtt ccaggttgtt ccctgttgtt tggttggacg 3480 ctgtcccctg ttgtttggtt ggagcggagc tgacctgacg gttccaggct gttccctgtt 3540 gtttggttgg agcggagctg acctgactgt tccaggctgt tccctgttgt ttggttggac 3600 gctgtcccct gttgtttggt tggagcggag ctgacctgac ggttccaggc tgtcccctgt 3660 tgtttggctg gagcggggct gacctgacgg ttccaggctg ttccctgttg tttggctgga 3720 gcggggctga cctgacggtt ccaggctgtt ccctgttgtt tggctggagc ggggctgacc 3780 tgacggttcc aggctgttcc ctgttgtttg gctggagcgg ggctgacctg acggttccag 3840 gctgttccct gttgtttggc tggagcgggg ctgacctgac ggttccaggc tgttccctgt 3900 tgtttggctg gagcggggct gacctgacgg ttccaggctg ttccctgttg tttggttgga 3960 gcggagctga cctgacggtc ccggcgctgt tcgtgtaagt tgtttctgtt tccctgttat 4020 tttgaatata cttaaatggc ccaataattc catttctgtg aacctaagag tataaacatt 4080 tcataagatt attgaactta aagtgatagg cctggctgga aatattttac cccatacctg 4140 tgcttatttc tttttaatga gcaactgaaa agtaatttta gtaaccaacc tcccatacct 4200 ttggagaaca aataaaacca cagtaatttc cacgtattaa gagcccacat gcgcctatca 4260 ctgtcatcca cagtctgcac ctgttagctt gtttaagcct cccaggagct tgcacagagt 4320 atggccagat acccgcctta cagcctgtgc tgctgtggcc aaggaaaaga ggttttgtgc 4380 ctggggcagt cagaccttcc agtgggagtg actcttggct gctccctgcc cgtcctcagt 4440 tgctttttgg tggaagtgca ggcccctctc tccccactct gccctcccag ccacctgagc 4500 cactgagctt ctgcagcagc acaagccctt tcagtcttcc tgagtcggcc ccactctggg 4560 gtgggctccc gcttttaggc tctttgcttt cacaatcaaa gttacaacgg gaagcccttc 4620 actcggggcc ggcgggaaag gatccagccc tgctacttcc attctttcct tttaaacaag 4680 actctgtcca ttaatcatcc tctggtttga tctgtcaatc cagaaaccct tgctaatgct 4740 ttatggctgt ggtttgttgc ggttctggga aagaggaaaa gaaatgagcc agtcctaata 4800 aatgaaagtt atttcctcat ttgaatttct gagtcctgag agtcaatatg atgcagacat 4860 caatcttgtt attctcggag tggagagaca gtttctgatt gtgcctctcc ctgggttgtg 4920 atgataaaac gtgtggtgtg tttggctggg ctcagtcatg gcctctcctg agaccccctg 4980 cctttttata ttgcagataa cacacatggc ttaatgctgg aaacaggcct gtgttccctt 5040 ggtctttacg agtgttattc tagaaaactt catgtttcta aggtggtttc atttgtcatg 5100 aatactcaga tgcggttttc tctagcagcc ctccgagtgt gctcggaaag gtgaggcccc 5160 cgaggcagag gcatggccag gacgctggtg ggcttctttg ggaattagga ggaaaaagag 5220 gagtggggca gagcctggag aggctgccct cctggggtgc aggccggtgg aggatgtgga 5280 gctgcccagc tggcaggtgg cagaattggg actgaagctc agtccccact cgtccaggcc 5340 acagcttctc ctttggggcc actctgcctc attcaccatc tctccagcac caagcaattg 5400 tgtgattctt acaatgtgcc tgtcgtgctt ctggtcgcag cctccttggc tttgcagcag 5460 tgcagtgcct gggcctgcat ttggcagaag tggagttccc agtcccatcc gtggagtggc 5520 cttcccctga gagcttgcct ggtatgtttc agatgcaggg gcttctgtct ctccatgcct 5580 tatgcacttg gccacacccc tgttagcacc cctgccattt cccagggcca ctgttgcagg 5640 cacccaggaa ggtgcctgac ctggctctac atcccacacc ctgtgcaggg ggcctagcat 5700 gctggcagcc tgctaagagc tggatag gta tgt ggt gag cac atg gca ccc cga 5754 Val Cys Gly Glu His Met Ala Pro Arg 1 5 tcc gat tta ctt ggt gtc ctg tcg ggc aca ctt gtg aat acc cgc cag 5802 Ser Asp Leu Leu Gly Val Leu Ser Gly Thr Leu Val Asn Thr Arg Gln 10 15 20 25 gcc tgt gtg tgg gtg gag aca gaa cct gcc ctc tgg cca tcg agg ctg 5850 Ala Cys Val Trp Val Glu Thr Glu Pro Ala Leu Trp Pro Ser Arg Leu 30 35 40 tgc ctc ttg gcc ata cat gtc atg gtc ttg ttc atc aga cct gcc ctg 5898 Cys Leu Leu Ala Ile His Val Met Val Leu Phe Ile Arg Pro Ala Leu 45 50 55 cct gtc tgc tgg gag ggc ccg cat gga gcc tct tgc cca gct gca gac 5946 Pro Val Cys Trp Glu Gly Pro His Gly Ala Ser Cys Pro Ala Ala Asp 60 65 70 aag gga ggg tgaccggccc cacactccta tatgaaggat ggatagctct 5995 Lys Gly Gly 75 gggcagcttt ttggttctgg ggtcagattt gaatgtaaaa ctgaaaagtc ctaaatttat 6055 taaaggcttt cttttggggc tggaatatgc aatagatttt ctatccctct caattccctc 6115 ttaaaattta atactgccat aaaaatgatg gataacaaat tattccagga aaaatggtac 6175 tgaaagactc ttctaactgt tgaagcagaa gtacagactt ggcgaagaaa tagacatgac 6235 ccagaaaact cacgaggaaa gaggaaatcg tgtactttgt ggaaaccata tccacgtaat 6295 gttgttccag gctgtagaaa gcaactattg ttattccaga tactgaagca cagagtctat 6355 tttgtgccgc tggcggtttc attaacatag taacactctg cctttctaga attgggtgag 6415 cagccttccc tgtttggaac actgcagagg gagactgaac cccacaattg atatcagaag 6475 gccccgtgtg gatgcctctt cagggtgcct tccacagagc tctgccagca tgctgaggct 6535 gcggggaaaa accatgaagc ctcataaata tatacaatga ttgtgtgtac ccataatcat 6595 tagaaataaa aatttaaaaa aacacataaa accacaaggg ctctgattgc tgggtctagg 6655 acttccccac tccgacagtg atggtagcag aaacaaggcc tgacagccag accccagggc 6715 aggcagcagg gaggaaaaca gatttaaaaa tcgcaccaga cactcatttt ctacagaagt 6775 ctgcgtgtcg ttaatacatg ggcaaacagc cctttgttcc ttagtaggcc ttaaagacac 6835 caccccatgg gagctttcta aaaaagatag tattaaaaga ctatgattca ggctgggcac 6895 attagcacac acctgtaatc tcagcacttt ggaaggtcga ggagggcaga tcacttgagt 6955 ctaggagttt gagaccagcc tgggcaacat agcaagacct gatctctcta caaaaattag 7015 ctgagtatgg tggcatacac ctctggtctc agctactcgg gaggatcagt cgggccccgg 7075 aggttgaggc tgcagtgagc tatgatcgca ccactgtact ctagcctggg tgacagtgag 7135 acccagtctc aaaagcaaaa caaaacaccc cacaaagtat ataattcaga cttaacatcc 7195 tgactcttgt ttttactcca aggcaatgaa gcaatgatgt ggacgatgcg tgtcctaatc 7255 cggagcgcct cccaggctag gaatccaagc caggttatgg cttaaatgga gaccgatgga 7315 gctgctagct gagatcgccc acattggcct ctgcagactc ccttgttttc cctaatgtgt 7375 gtcaacacat ctattaaggg gaaaggactg ctcggtatca atgatttcca cttggaaatg 7435 tcaccatgac aactgaggag gtgctggaag caggcacttt gttaattctg tcttaaccca 7495 tcccaggcaa cttcaaaact ttttctctgg agagaaatag gcttatttag gaaaggcgtc 7555 tctcattgat cctcagctac atccactgaa gtgaataatt tacttctttg gcaggtttag 7615 aaaattagat gcatacaatc taatatccct tctttgtaca ttttcatgtg aaatcttttg 7675 gagtgctttt tgatagccac cccctcgggg acctggaagt ggcactgtct gaattctgtt 7735 ctgtcggttc tgtgagggac agatgctcca tgtcatcctg agagccatcc taccgccttc 7795 ctgcccagtc ctcttcactg gcacctccat tggccaacag atcaagtctg cacaccgcag 7855 cctggctgcg agggtccttt tcatccagcc tcattcatca gtgttcttgt gagcatctac 7915 tctgggttag gcccagacct cctgggttaa tcagattgaa caaaggggtg taatagagaa 7975 ccaaagggcc aggtgcggtg gctcacgcct gtaatcccac cactttggga ggccaaggca 8035 ggcagatcac gaggtcagga gattgagacc atcctggcta gcacagtgaa accctgtctc 8095 tactaaaaat acaaaaaatt agccacgcat gttggcgggc gcctgtagtc ccagctgctc 8155 ggtaggctga ggcaggagaa tggcgtgaac cagggaggcg gagcttgcag tgagacgaga 8215 tcacaccact gcagtccagc ctgggcgaca gagcgagatt ccgtctc 8262

───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.⁷ 識別記号 ＦＩ テーマコート゛(参考） Ａ６１Ｋ 48/00 Ａ６１Ｋ 37/02 (72)発明者 中島 大輔 千葉県木更津市矢那1532番３号 財団法人 かずさディー・エヌ・エー研究所内 Ｆターム(参考） 4B024 AA01 AA11 CA04 EA04 GA14 HA01 4B050 CC03 DD11 LL01 LL03 4C084 AA01 AA13 BA35 4C087 BC83 CA12 NA14 4H045 AA10 BA10 CA40 EA20 EA50 FA74

Claims (5)

【特許請求の範囲】
1. 【請求項１】 以下の（ａ）又は（ｂ）のポリペプチド
   をコードする塩基配列を含むＤＮＡ： （ａ）配列番号：１乃至４４（但し、配列番号７、１１
   及び２５は除く）のいずれか一つで示されるアミノ酸配
   列と同一又は実質的に同一のアミノ酸配列から成るポリ
   ペプチド、 （ｂ）配列番号：１乃至４４（但し、配列番号７、１１
   及び２５は除く）のいずれか一つで示されるアミノ酸配
   列において、一部のアミノ酸が欠失、置換又は付加され
   たアミノ酸配列から成り、（ａ）のポリペプチドの機能
   と実質的に同質の生物学的活性を有するポリペプチド。
2. 【請求項２】 以下の（ａ）又は（ｂ）のＤＮＡ： （ａ）配列番号：１乃至４４（但し、配列番号７、１１
   及び２５は除く）のいずれか一つで示される塩基配列に
   おいて、夫々の配列で示されるアミノ酸配列をコードす
   る塩基配列を含むＤＮＡ、 (ｂ）（ａ）のＤＮＡとストリンジェントな条件下でハ
   イブリダイズし、（ａ）のポリペプチドの機能と実質的
   に同質の生物学的活性を有する蛋白質をコードするＤＮ
   Ａ。
3. 【請求項３】 請求項１又は２記載のヒトＤＮＡを含む
   遺伝子。
4. 【請求項４】 以下の（ａ）又は（ｂ）の組換えポリペ
   プチド： （ａ）配列番号：１乃至４４（但し、配列番号７、１１
   及び２５は除く）のいずれか一つで示されるアミノ酸配
   列と同一又は実質的に同一のアミノ酸配列から成るポリ
   ペプチド、 (ｂ）配列番号：１乃至４４（但し、配列番号７、１１
   及び２５は除く）のいずれか一つで示されるアミノ酸配
   列において、一部のアミノ酸が欠失、置換又は付加され
   たアミノ酸配列から成り、（ａ）のポリペプチドの機能
   と実質的に同質の生物学的活性を有するポリペプチド。
5. 【請求項５】 請求項３に記載の遺伝子にコードされる
   組換え蛋白質。