JP2003113031A - Skin care preparation - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a skin care preparation which has safety, bleaching effect, inhibitory effect on active oxygen, amelioration effect on chapped skin, firmness of the skin and amelioration effect on wrinkles and spread of cosmetic. SOLUTION: This skin care preparation comprises one or more kinds of extracts of Aeschynomene indica L., Alysicarpus vaginalis, Anthyllis vuleneraia L., Butea monosperma, Cercis chinesis, Campylotropis trigonoclada Schindl, Campylotropis ichangensis Schindl, Campylotropis delavayi Schindl, Campylotropis hirella Schindl, Fordia cauliflora, Lysidice rhodostegia, Lotus corniculatus L., Lotus tenuis Kitag, Lathyrus quinquenervius Litv, Lathyrus maritimus Bigel, Moghania macrophylla, Moghania philippinensis, Moghania strobilifera and Ormosia henryis Prain and is known to have improved bleaching effect, amelioration effect on chapped skin, firmness of the skin, amelioration effect on wrinkles, spread of cosmetic and high effectiveness as a skin care preparation. The extracts have been utilized for medicinal use from long ago and it goes without saying that these extracts have no problem at all in terms of safety from the results of various tests.

Description

Description: BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external preparation for skin such as pharmaceuticals, quasi-drugs and cosmetics. For more details, Kusanem, Sasahagi and Wound. Klee, Juketsu, Hanazu-oh, San-Yoshi-Ko-shi-shaw, Giant-faced-ki-shaw-shaw, Seinan-shi-ko-sha-shi, Skeweed-shaw-shaw, Kanka-tou, Jin-hoa, Miyakogusa, Watari-miyako-gusa, Ren-ri-so, Hama-endo, Daisen-kinbatsu, Tulsen-kin-batsu, Malhovana-Kin-batsu, Malhovana-Kin-batsu The present invention relates to a safe and effective skin external preparation characterized by incorporating at least one extract. 2. Description of the Related Art Xanem (scientific name: Aesynome)
ne indica L. ) Ranges from temperate to tropical,
In Japan, it is an annual plant widely found in wetlands such as rice fields and riversides. Whole grass is used as diuresis. Sasahagi (scientific name = Alysicarpus vagin)
alis) is a perennial plant that is widely distributed in the tropics of the eastern hemisphere and grows in vacant lots and grasslands, and its seed is used as an indigestion and cough medicine. Und. Clay (scientific name = Anthyllis vule
neraria L. ) Are widely found on lawns, forests and roadsides in Europe. Whole grass is used to treat bruises and wounds. [0003] Juketsu (scientific name = Butea monos)
perma) is a tall tree with a height of 10 to 30 m, which is distributed in forests of India, Sri Lanka and Myanmar, and its leaves are used for diuresis and convergence. Hanazou (scientific name = Cercis chinensi
s), also known as Shijing, is a shrub distributed along the mountain slopes and mountain streams in northern, southern, central and southwestern China and in shrub bushes, and its bark (purple thorn bark) is applied to bruises and the like. Sanryo Oshiwashi (Surrounded by three ridges) (scientific name = C
ampytropis trigonoclada
Schindl) is a shrub that grows on mountain slope forests and shrub bushes in Yunnan, Guizhou and Sichuan provinces of China, and uses foliage and roots for fever and bruises. Gishokushiyusha (Yichang pile branch) (scientific name = Campy)
lotropis ichangensis Schi
ndl) is a shrub that grows on grass slopes and valleys in the mountains of Sichuan, Hubei, Jiangxi, Anhui and Jiangsu provinces in China, and uses its branches and leaves for diarrhea and bruises. Seinanushi-shi (Southwest pile support) (scientific name = Camp)
ylotropicsdelavayi School
l) is a shrub that grows in bushes and plexus of shrubs in dry areas in Yunnan, Guizhou and Sichuan provinces of China, and uses foliage and roots for fever and bruises. Scarlet Shaw (hair pile support) (scientific name = Campylot)
(ropis hirtella Schindl) is a shrub that grows in mountain valleys, paddy fields, flora, and shrubs in mountainous areas of Yunnan and Sichuan provinces in China, and uses branches and leaves and roots for congestion and detoxification. [0004] Kankato (stem flower bean) (scientific name = Fordi)
a cauliflora is a shrub that grows on mountain slopes, in valleys, and in valleys in Guangxi Autonomous Region, Guangdong Province, China, and uses its branches and leaves and roots for rheumatoid arthritis and bruises. Jinhua (scientific name = Lysidice rhodoste)
Gia) is a tree that grows in Yunnan, Guizhou, Guangxi, and Guangdong provinces of China and in riversides and coppice forests in Taiwan, and uses its branches and leaves for congestion and swelling. Lotus japonicus (scientific name = Lotus corniculat
us L. ) Is a perennial plant that grows in temperate zones such as Japan, China, Taiwan, Korea, the Himalayas, Oceania, North America, and northern Africa, and in subtropical roadsides, plexuses, and rice fields. Cottonweed (scientific name = Lotus tenuis)
Kitag) is a perennial plant that grows in the provinces of Gansu, Shaanxi, Shanxi and Guizhou in China, Xinjiang Uygur Autonomous Region and grasslands and watersides in Europe. [0005] Lotus root (scientific name = Lathyrus q
uinquenervius Litv or L. pa
lustris L .; var. lineaifoli
u) is a perennial plant that grows in temperate and slightly humid grasslands in Honshu, Kyushu, Korea, China and East Siberia in Japan, and detoxifies the whole plant and uses it for scabies. Yellow pea (scientific name = Lathyrus mariti
mus Bigel) is a perennial plant that grows on the sandy shores of temperate to temperate shores in Japan, northern Asia, northern Europe, and North America, and uses whole plants as medicines. The enamel bean (Scientific name = Moghaniamacrophylla) is a shrub that grows on mountain slopes, wastelands and shrub bushes in the provinces of Jiangxi, Fujian, Sichuan, Yunnan, Guizhou, Guangxi, Guangdong and Taiwan. The root is used for rheumatoid arthritis and bruises. Tsursenkinbatu (vines 1000 buns) (scientific name = Moghan
ia philippinensis) is Hunan, China.
The roots of the shrubs in Hubei, Guizhou, Guangxi, Guangdong, Fujian provinces and mountains of Taiwan and the Philippines are used to promote and sweat the roots. Malhovana Senkinbats
Ghonia stabilifera is a shrub that grows in the provinces of Yunnan and Guangdong in China, and in the flora of Taiwan, the Philippines, India and Malaysia, and its roots are used for coughing and expectorant. Karinboku (Kariniki) (scientific name = Ormosia hen)
(ryi Plan) is an evergreen small tree that grows in the provinces of Hunan, Hubei, Jiangxi, Fujian, Sichuan, Yunnan, Guizhou, Guangdong, Anhui, Zhejiang and Vietnam. [0006] Skin external preparations such as cosmetics are often used continuously for a long period of time, and are applied to organs having a large area such as the skin. There is a variety of efficacy requirements for skin external preparations, but whitening is particularly important in Japan because white skin is preferred. is there. Further, there is a demand for an effect of improving rough skin, an effect of improving skin swelling, wrinkles, and an effect of improving makeup sizing. Means for Solving the Problems As a result of intensive studies in consideration of safety and effectiveness with the skin, Kusanem, Sasahagi, Undo. Clay, Juketsu, Hanazuo, Sansho-shikihoshi, Gyokushikihoshihashi, Seinanshihihashi, Kokeshishah, Kankatou, Jinhua, Miyakogusa, Watarimiyakogusa, Renrensou, Hamaendo, Daisenkinbatsu, Tsurusenkinbatsu, Marhobanasenbuki It has been found that compounding the product is optimal for the purpose of the present invention. [0008] Kusanem, Sasahagi, Undo. Clay, Juketsu, Hanazuo, Sansho-shikihoshi, Gyokushikihoshihashi, Seinanshihihashi, Kokeshishah, Kankatou, Jinhua, Miyakogusa, Watarimiyakogusa, Renrensou, Hamaendo, Daisenkinbatsu, Tsurusenkinbatsu, Marhobanasenbuki There is no particular limitation on how to use the product extract,
When used as an extract, to facilitate extraction,
If necessary, cut and crush with a mixer. This is extracted with water or a hydrophilic organic solvent. The hydrophilic organic solvent used is methanol, ethanol, acetone, glycerin,
1,3 butylene glycol, propylene glycol, etc.
Alternatively, the mixture is extracted with a mixture thereof, or a mixture of at least one hydrophilic organic solvent and water. However, since it is a preparation to be applied to the skin, a solvent having no problem even when used for an external preparation for skin, such as water, ethanol, and glycerin, has a wider range of use because there is no need to remove the solvent. In our experiments, hot water extraction or a low concentration aqueous solution of a hydrophilic organic solvent is preferred. The extraction conditions vary depending on the degree of cutting, the purpose, and the type of the solvent, but when only water is used, considerable heating is possible, and even when the temperature is increased to 100 ° C., the effectiveness does not decrease significantly.
Depending on the type of the solvent and the form of the external preparation for skin, one part or all of the solvent is distilled off. This is mixed with a skin external preparation. Kusanem, Sasahagi, Undo. Clay, Juketsu, Hanazuo, Sansho-shikihoshi, Gyokushikihoshihashi, Seinanshihihashi, Kokeshishah, Kankatou, Jinhua, Miyakogusa, Watarimiyakogusa, Renrensou, Hamaendo, Daisenkinbatsu, Tsurusenkinbatsu, Marhobanasenbuki The compound is mixed with the external preparation for skin, and it varies depending on the extraction method and the purpose of mixing, but the compounding amount is preferably 0.0001 to 5.0% as a solid content. In addition, since the other ingredients to be blended are not limited, they may be freely selected, but it is a matter of course that ingredients that do not contradict the purpose of the safe and effective skin external preparation of the present invention are selected. It is. For this reason, the use of various agents effective for whitening, antioxidation, cell activation (prevention of cell aging), moisturization, prevention of rough skin and improvement thereof makes the object of the present invention more effective. In addition, there is no problem in selecting an arbitrary dosage form such as a cream, an emulsion, a lotion, a pack, a spray, and a gel depending on the use and the like. [0010] In the following, a production example as an example of an actual extraction method and an example in which the production example is blended will be described. Production Example 1 After cutting 100 g of dried whole plant of Kusanem, 2 kg of purified water was added, heated to 80 ° C., and after 5 hours, allowed to cool, filtered with filter paper, and the filtrate was filtered. It was concentrated under reduced pressure. Production Example 2 After 100 g of dried whole plant of Kusanem was chopped, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was allowed to stand for 10 days with stirring. After filtration with filter paper, the filtrate was concentrated under reduced pressure. . Preparation Example 3 After cutting 100 g of dried whole plant of Kusanem, 1 kg of purified water and 1 kg of 1,3-butylene glycol were added, and the mixture was allowed to stand for 10 days with stirring. Was concentrated under reduced pressure. Production Example-4 After cutting 100 g of dried seeds of Sasahagi, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was allowed to stand for 10 days with stirring. After filtration with filter paper, the filtrate was concentrated under reduced pressure. Production Example-5 Wind. After shredding 100 g of the dried clay whole plant,
After adding 1 kg of purified water and 1 kg of ethanol, the mixture was allowed to stand with stirring for 10 days, filtered with a filter paper, and the filtrate was concentrated under reduced pressure. Production Example-6 After cutting 100 g of dried dried bean leaves, chopped purified water 1
After addition of 1 kg of ethanol and 1 kg of ethanol, the mixture was allowed to stand with stirring for 10 days, filtered through filter paper, and concentrated under reduced pressure. Preparation Example 7 After 100 g of dried bark of Hanazou were cut into small pieces, 2 kg of purified water was added, heated to 80 ° C., and after 5 hours, allowed to cool, filtered with filter paper, and the filtrate was decompressed. Concentrated. Production Example-8 After cutting 100 g of dried bark of the Japanese bark, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred for 10 hours.
After standing for a day, the mixture was filtered with filter paper, and the filtrate was concentrated under reduced pressure. Production Example-9 After cutting 100 g of dried leaves of the leaves of Sanrius oxensis, 1 kg of purified water and 1 kg of ethanol were added.
After standing for 10 days while stirring, the mixture was filtered with filter paper, and the filtrate was concentrated under reduced pressure. Production Example-10 After cutting 100 g of the dried product of the root of the sorghum magpie, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was allowed to stand for 10 days with stirring. After filtration with filter paper, the filtrate was decompressed. Concentrated. Preparation Example 11 After cutting 100 g of the dried leaves of the leaves of Saenanthus oleracea, 2 kg of purified water was added, the mixture was heated to 80 ° C., after 5 hours, allowed to cool, filtered through filter paper, and filtered. Was concentrated under reduced pressure. Production Example-12 After 100 g of dried roots of S. antelope were chopped, 2 kg of purified water was added, the mixture was heated to 80.degree. C., after 5 hours, allowed to cool, filtered through filter paper, and filtered. Was concentrated under reduced pressure. Production Example-13 After cutting 100 g of the dried product of the branches and leaves of Betula lucidum,
After adding 1 kg of purified water and 1 kg of ethanol, the mixture was allowed to stand with stirring for 10 days, filtered with a filter paper, and the filtrate was concentrated under reduced pressure. Preparation Example 14 After cutting 100 g of dried root of Betula serrata, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred for 1 hour.
After standing for 0 days, the mixture was filtered with filter paper, and the filtrate was concentrated under reduced pressure. Production Example-15 After 100 g of the dried leaves of Kankatou were cut into small pieces, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred for 10 minutes.
After standing for a day, the mixture was filtered with filter paper, and the filtrate was concentrated under reduced pressure. Production Example 16 After 100 g of dried dried coconut root was cut into pieces, 1 kg of purified water and 1 kg of ethanol were added, the mixture was allowed to stand with stirring for 10 days, filtered through filter paper, and concentrated under reduced pressure. Production Example 17 After 100 g of the dried leaves of Jinhua were cut into small pieces, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was allowed to stand for 10 days with stirring. After filtration with filter paper, the filtrate was concentrated under reduced pressure. Production Example 18 After 100 g of the dried product of the root of Jinhua were chopped, purified water 1
After addition of 1 kg of ethanol and 1 kg of ethanol, the mixture was allowed to stand with stirring for 10 days, filtered through filter paper, and concentrated under reduced pressure. Production Example-19 After 100 g of dried root of Lotus japonicus was chopped, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was allowed to stand for 10 days with stirring. After filtration with filter paper, the filtrate was concentrated under reduced pressure. Preparation Example 20 After 100 g of dried root of Lotus japonicus was chopped, 2 kg of purified water was added, heated to 80 ° C., and after 5 hours, allowed to cool, filtered with filter paper, and the filtrate was decompressed. Concentrated. Production Example 21 After chopping 100 g of dried leaves of cottonweed leaves,
After adding 1 kg of purified water and 1 kg of ethanol, the mixture was allowed to stand with stirring for 10 days, filtered with a filter paper, and the filtrate was concentrated under reduced pressure. Production Example-22 After 100 g of dried whole plant of spinach was chopped, 1 kg of purified water and 1 kg of ethanol were added, and 10 g of the mixture was stirred.
After standing for a day, the mixture was filtered with filter paper, and the filtrate was concentrated under reduced pressure. Preparation Example 23 After 100 g of dried whole plant of spinach was chopped, 2 kg of purified water was added, the mixture was heated to 80 ° C., 5 hours later, allowed to cool, filtered through filter paper, and filtered. It was concentrated under reduced pressure. Production Example-24 After cutting 100 g of dried whole plant of cucumbers, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred for 1 hour.
After standing for 0 days, the mixture was filtered with filter paper, and the filtrate was concentrated under reduced pressure. Production Example-25 After cutting 100 g of dried roots of radish, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was allowed to stand with stirring for 10 days. After filtration with filter paper, the filtrate was filtered. It was concentrated under reduced pressure. Production Example-26 100 g of dried roots of malhovana serrata were chopped, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was allowed to stand with stirring for 10 days. After filtration with filter paper, the filtrate was filtered. It was concentrated under reduced pressure. Production Example 27 After drying 100 g of dried roots of malhovana serrata, 1 kg of purified water and 1 kg of 1,3-butylene glycol were obtained.
Was added, and the mixture was allowed to stand for 10 days with stirring. After filtration with filter paper, the filtrate was concentrated under reduced pressure. Production Example-28 After cutting 100 g of dried Karinboku branches and leaves, 1 kg of purified water and 1 kg of ethanol were added, and the mixture was stirred for 10 minutes.
After standing for a day, the mixture was filtered with filter paper, and the filtrate was concentrated under reduced pressure. In the examples, the formulations shown in Table 1 are used. Both A and B are heated and dissolved at 80 ° C., and B is gradually added to A while stirring to emulsify. The mixture was cooled with stirring, the stirring was stopped at 35 ° C., and a cream was prepared by leaving the mixture. [Table 1] Example 5 The same procedure as in Example 1 was carried out except that Production Example 1 of Example 1 was replaced with Production Example 4. Example 6 The procedure of Example 2 was repeated except that Production Example 2 of Example 2 was replaced with Production Example 5. Example 7 The procedure of Example 3 was repeated except that Production Example 3 of Example 3 was replaced with Production Example 6. Example 8 Production Example 1 of Example 1 is Production Example 4 and Production Example 2 is Production Example 5.
Then, Production Example 3 was replaced with Production Example 6, and the other conditions were the same as in Example 4. Example 9 The procedure of Example 1 was repeated except that Production Example 1 of Example 1 was replaced with Production Example 7. Example 10 The same procedure as in Example 2 was repeated except that Production Example 2 of Example 2 was replaced with Production Example 8. Example 11 The procedure of Example 3 was repeated except that Production Example 3 of Example 3 was replaced with Production Example 9. Example 12 Manufacturing Example 1 of Example 1 is changed to Manufacturing Example 7, and Manufacturing Example 2 is changed to Manufacturing Example 8.
Then, Production Example 3 was replaced with Production Example 9, and the other conditions were the same as in Example 4. Example 13 The same procedure as in Example 1 was carried out except that Production Example 1 of Example 1 was replaced with Production Example 10. Example 14 The procedure of Example 2 was repeated except that Production Example 2 of Example 2 was replaced with Production Example 11. Example 15 The same procedure as in Example 3 was carried out except that Production Example 3 of Example 3 was replaced with Production Example 12. Example 16 Production Example 1 of Example 1 was replaced with Production Example 10, Production Example 2 was replaced with Production Example 11, and Production Example 3 was replaced with Production Example 12, except for Example 4. Example 17 The procedure of Example 1 was repeated except that Production Example 1 of Example 1 was replaced with Production Example 13. Example 18 The same procedure as in Example 2 was carried out except that Production Example 2 of Example 2 was replaced with Production Example 14. Example 19 The procedure of Example 3 was repeated, except that Production Example 3 of Example 3 was replaced with Production Example 15. Example 20 Production Example 1 of Example 1 was replaced with Production Example 12, Production Example 2 was replaced with Production Example 13, Production Example 3 was replaced with Production Example 6, and the rest of Example 1 was replaced with Production Example 6.
4 was prepared in the same manner. Example 21 The procedure of Example 1 was repeated except that Production Example 1 of Example 1 was replaced with Production Example 16. Example 22 The same procedure as in Example 2 was repeated except that Production Example 2 of Example 2 was replaced with Production Example 17 to produce the same. Example 23 The same procedure as in Example 3 was carried out except that Production Example 3 of Example 3 was replaced with Production Example 18. Example 24 Production Example 1 of Example 1 was replaced with Production Example 16, Production Example 2 was replaced with Production Example 17, and Production Example 3 was replaced with Production Example 18, except that Example 4 was prepared. Example 25 The same procedure as in Example 1 was carried out except that Production Example 1 of Example 1 was replaced by Production Example 19. Example 26 The same procedure as in Example 2 was carried out except that Production Example 2 of Example 2 was replaced with Production Example 20. Example 27 The same procedures as in Example 3 were carried out except that Production Example 3 of Example 3 was replaced with Production Example 21. Example 28 Production Example 1 was replaced with Production Example 19, Production Example 2 was replaced with Production Example 20, and Production Example 3 was replaced with Production Example 21. Example 29 A device was prepared in the same manner as in Example 1 except that Production Example 1 of Example 1 was replaced with Production Example 22. Example 30 A device was prepared in the same manner as in Example 2 except that Production Example 2 of Example 2 was replaced with Production Example 23. Example 31 The procedure of Example 3 was repeated except that Production Example 3 of Example 3 was replaced by Production Example 24. Example 32 The same procedure as in Example 4 was carried out except that Production Example 1 of Example 1 was replaced with Production Example 22, Production Example 2 was replaced with Production Example 23, and Production Example 3 was replaced with Production Example 24. Example 33 The procedure of Example 1 was repeated except that Production Example 1 of Example 1 was replaced with Production Example 25. Example 34 The same procedure as in Example 2 was carried out except that Production Example 2 of Example 2 was replaced with Production Example 26. Example 35 The same procedure as in Example 3 was carried out except that Production Example 3 of Example 3 was replaced with Production Example 27. Example 36 Production Example 1 of Example 1 was replaced with Production Example 25, Production Example 2 was replaced with Production Example 26, and Production Example 3 was replaced with Production Example 27, and the other processes were the same as in Example 4. Example 37 The procedure of Example 1 was repeated except that Production Example 1 of Example 1 was replaced with Production Example 28. The following experiment was conducted to confirm the effect. On the basis of the following criteria, 5 persons per experiment
After a month of use, we heard about the whiteness of the skin, the effect of improving the roughness of the skin, the effect of improving skin swelling, wrinkles, and the application of makeup. The results are shown in Tables 2 and 3. The numbers represent average values. (Note that
No one complained of skin abnormalities during the test period) Very improved compared to before use 3 Improved compared to before use 2 Slightly improved compared to before use 1 Change from before use None 0 Deteriorated compared to before use -1 Deteriorated compared to before use -2 Very deteriorated compared to before use -3 [Table 3] As for the safety test, a primary skin irritation test, a cumulative skin irritation test, a sensitization test, and a human patch test were performed, but no problem was found. According to the present invention, Xanem, Sasahagi, Undo. clay,
Juketsu, Hanazu-oh, San-Yoshi-Koushi-shaw, Giant-short-faced ox-shape, Seinan-shi-ko-sha-shi, Koke-shi-ko-sha, Kanka-tou, Jin-ho-a, Lotus japonicus, Watari-ya-kogusa, Renrensou, Hama-endo, Daisen-kin-batsu, Tsuru-sen-kin-batsu, Mar-ho-ka-ka-n-ba-k-in An external preparation for skin characterized by combining one or more kinds, a whitening effect, a skin roughness improving effect, a skin sticking,
It has been found that the effect of improving wrinkles and the application of makeup are improved, and that it is highly effective as an external preparation for skin. Needless to say, it has been considered edible since ancient times, and there is no problem in safety at all from the results of various tests.

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Claims (1)

[Claim 1] Kusanem, Sasahagi, Undo. Clay, Juketsu, Hanazuo, Sansho-shikihoshi, Gyokushikihoshihashi, Seinanshihihashi, Kokeshishah, Kankatou, Jinhua, Miyakogusa, Watarimiyakogusa, Renrensou, Hamaendo, Daisenkinbatsu, Tsurusenkinbatsu, Marhobanasenbuki External preparation for skin characterized by incorporating at least one kind of substance