JP2003081844A - Skin irritation relief agent - Google Patents

Abstract

(57) [Solution] An agent for alleviating skin irritation by a plant extract comprising cedrol. Component (A) cedrol and component (B)
An external preparation for skin containing a plant extract. [Effect] The present invention has an excellent effect of alleviating skin irritation caused by a plant extract, and the external preparation for skin of the present invention can alleviate skin irritation of a plant extract and increase the content thereof. It has excellent effects of plant extracts, such as reduction of rashes such as acne, improvement of dryness, and reduction of desquamation.

Description

Detailed Description of the Invention

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a skin irritation relieving agent and a skin external preparation with reduced skin irritation caused by a plant extract comprising cedrol.

[0002]

2. Description of the Related Art Human skin has a proper moisturizing property when it is in a healthy state, and usually does not require special care.
However, the skin may be changed or hindered by various environmental factors (for example, temperature change, humidity change, contact with light or water), contact with chemical substances, or aging. Various plant extracts have an improving effect against such changes and obstacles, and are essential components for the current cosmetics.

[0003]

However, the amount that can be blended is limited due to problems such as irritation while having excellent effects, and it cannot be said that the original effects are sufficiently exhibited. Also, removing stimulants from these plant extracts would be costly and impractical. The purpose of the present invention is to
It is intended to provide a skin irritation alleviating agent for alleviating skin irritation of a plant extract and a skin external preparation containing the same.

[0004]

[Means for Solving the Problems] The present inventors have found that cedrol has an excellent stimulant alleviating action, and by using it in combination with various plant extracts, the content of the plant extract can be dramatically increased. It was found that a skin external preparation capable of exerting the original effect of the extract can be obtained.

The present invention provides a skin irritation alleviating agent using a plant extract comprising cedrol. Also,
The present invention provides a skin external preparation containing the following components (A) and (B): (A) cedrol and (B) plant extract.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The skin irritation relieving agent of the present invention comprises cedrol, which is one of sesquiterpene alcohols and has optical isomers, but preferably d represented by the formula (1). It is the body.

[0007]

[Chemical 1]

Cedrol is generally known as a perfume ingredient contained in essential oils of plants such as the genus Himalayan, the cypress family Raptor, juniper, and kurobe. Further, it can be obtained by refining from an essential oil such as cedar wood oil and hiba oil by distillation or the like, but it can also be obtained by synthesis. Cedrol used in the present invention is an essential oil refined product,
Any of synthetic products may be used, and commercially available products may be used.

When the purity of cedrol is low, the influence of other coexisting components remains, and the crystal form of cedrol tends not to be easy to handle. Therefore, the purity is preferably 70% or more. More preferably 8
0%, more preferably 90% or more, still more preferably 95% or more, particularly preferably 97.0% or more.

Component (A) used in the external preparation for skin of the present invention
The content of sedrol in the external preparation for skin can be appropriately selected depending on the usage form, purpose of use, usage method, dosage form, etc.
It is usually 0.001 to 10% by weight (hereinafter simply referred to as%), preferably 0.1 to 5%.

Component (B) used in the external preparation for skin of the present invention
The plant extract of is a plant extracted with a solvent such as an organic solvent, water or an aqueous solution of an inorganic salt, a steam distillate, a squeezed extract, etc., and the extract is directly used or further concentrated. May be used. Of these, solvent extracts are preferred. The extraction is usually performed by immersing the plant in a solvent at room temperature for 1 to 7 days, but when water or an aqueous solution of an inorganic salt is used, the extraction may be performed with heating. After the extraction, the solution is filtered and, if necessary, the extract is diluted or concentrated. In addition, the plant extract is commercially available, and thus may be used.

As the plant, any plant can be used as long as it has leaves, stems, roots, flowers, seeds and the like, and its medicinal effect on the skin has been confirmed. Regarding the medicinal effect on the skin, moisturizing effect, anti-inflammatory effect, blood circulation promoting effect, antibacterial effect, whitening effect, astringent effect, skin softening effect, hair growth effect, UV protection effect, deodorant effect, hair loss prevention, antioxidant effect, Among them, medicinal plants having a moisturizing effect, a whitening effect, an antibacterial effect, and an astringent effect are preferable as the plant used in the present invention.

As specific examples of preferable plants, as for moisturizing effect, Asunaro (Chamaeaceae, Asunaro), Buttonpi (Peonyceae, genus Button), Thyrus (Nutaceae, Dates), Carrot (Ceriaceae, Carrot), Horse chestnut (Echinaceae) Aesculus), Yuzu (Rutaceae citrus)
Extracts of plants selected from the group are aloe (Liliaceae, Aloe), Ougon (Lamiaceae, Spodoptera), Peony (Peonyaceae), Cha (Camellia camellia), Toki (Seriaceae). An extract of a plant selected from the group of the family of the family (Physaceae), the button (the family of the genus Button, genus Judithami), and the worm moth (the genus Rosaceae), which has an antibacterial effect. The extract of a plant selected from the group of chamomile (Chrysanthemum family Asteraceae), clove (Aceraceae Fusarium genus), Hammamelis (Hawthorne family Hawthorn genus) has the astringent effect on thistle (Asteraceae thistle),
Altea (Amaceae hollyhock genus), linden (Linaceae linden genus), eucalyptus (Butberry eucalyptus genus)
An extract of a plant selected from the group

In the external preparation for skin of the present invention, the component (B) is
The dry solid content is 0.001 to 0.5%, preferably 0.01 to 0.3%.

In addition to these components, the external preparation for skin of the present invention includes sequestering agents such as disodium edetate, trisodium edetate, sodium citrate, sodium polyphosphate, sodium metaphosphate and gluconic acid; caffeine,
Tannins, tranexamic acid and its derivatives; Tocopherol acetate, glycyrrhizic acid and its derivatives; Whitening agents such as vitamin C; Sugars such as glucose, fructose, trehalose; Polysaccharides such as xanthan gum, hyaluronic acid, pullulan, hydroxycellulose, carrageenan and mannan. It may contain polyethylene glycol having a molecular weight of 1000 or more. In addition to these components, components usually used for external preparations for skin such as cosmetics, for example, whitening agents, moisturizers, antioxidants, ultraviolet absorbers, surfactants,
Thickeners, alcohols, organic acids, alkalis, powder components, colorants, aqueous components, water, fragrances, various skin nutrition agents and the like can be appropriately added as needed.

The external preparation for skin of the present invention is, for example, a cream,
It is preferably used as a cosmetic such as emulsion, lotion, pack and gel.

[0017]

Example 1 A skin external preparation having the following composition was prepared. Composition 1: Cedrol 0.1% Asunaro extract Table 1 Polyoxyethylene (60) hydrogenated castor oil 1 Glycerin 5 Olive oil 1 1,3-butylene glycol 5 Purified water balance Composition 2: Asunaro extract Table 1 Polyoxyethylene (60 ) Hardened castor oil 1 Glycerin 5 Olive oil 1 1,3-butylene glycol 5 Purified water Balance production method: After heating and dissolving the oil phase component at 70 ° C., it was added to the heated water phase component and emulsified. After cooling, Table 1
The external preparation for skin was prepared by adding the asunaro extract of various concentrations described in 1.

(Stimulation Evaluation Method) Sensitive Skin Panelists (10
After washing the face with soap, the external preparation was applied to the skin, and after 1 minute, it was evaluated whether or not the skin felt a slight stimulus. Irritation judgment: A 0 people who felt a little stimulating feeling B 0 People who felt a little stimulating feeling 1-2 people C People who felt a little stimulating feeling 3 people or more The concentration which becomes C rank in irritation judgment It was judged to be irritating. The concentration of B rank immediately before that was defined as the maximum plant extract blending concentration, and the ratio of the plant extract maximum blending concentration with and without cedrol was defined as the plant extract blending concentration improvement rate (times).

(Formula) Plant extract compounding concentration improvement rate (times)
= (Maximum concentration of plant extract blended with cedrol) / (maximum concentration of plant extract blended with no cedrol)

The results are shown in Table 1. It was confirmed that in the external preparation for skin containing cedrol of the present invention, the concentration at which a stimulus derived from a plant extract is felt is increased, and the concentration at which the plant extract is mixed is increased.

[0021]

[Table 1]

Example 2 The same formulation as in Example 1 was used instead of the asunaro extract.
A skin external preparation was prepared using the plant extract described in 1.

(Plant Extract Maximum Blending Concentration) After determining the irritation at the blending concentration of each plant extract in the same manner as in Example 1, the maximum blending concentration was determined to contain cedrol.
The degree of improvement of the concentration of the plant extract in the absence of the substance was calculated.

(Skin quality improvement effect evaluation method) Professional panelists (1
0) is the maximum amount of the plant extract-containing external preparation for skin (control) containing the highest concentration of the plant extract in the case of not containing cedrol in the preceding paragraph, and the plant extract containing 0.1% of cedrol is the highest. The sedrol containing concentration and the external preparation for skin containing the plant extract were visually evaluated for the effect of improving the skin quality when used for one month in the usual manner. For the determination, the plant extract having a moisturizing effect has an effect of improving bulkiness, the plant extract having an antibacterial effect has a reduction in rashes such as acne, and the plant extract having astringent and whitening effects has a reduction in desquamation. The accompanying effect of improving the skin color was judged, and it was judged that there was an effect when three or more persons recognized an effect on the control for each effect.

[0025]

[Table 2]

[0026] Example 3 (milky lotion)   Cedrol 0.3%   Carrot extract (solid content 1.2%)   (50% 1,3 butylene glycol extract) 10   Sorbitan monostearate 1.5   Olive oil 2.5   Methyl polysiloxane (6cs) 0.5   Cholesterol 0.2   Cholesteryl isostearate 0.1   Behenyl alcohol 0.5   Batyl alcohol 0.3   Glycerin 10   Carboxyvinyl polymer   (Carbopol 980, manufactured by B.F.GOODRICH) 0.2   Potassium hydroxide 0.1   Succinic acid 0.01   Paraoxybenzoic acid ester 0.2   Purified water balance

[0027] Example 4 (gel)   Cedrol 0.1%   Eucalyptus extract (solid content 0.2%)   (50% 1,3 butylene glycol extract) 4   Altea extract (solid content 1.5%)   (30% 1,3 butylene glycol extract) 10   Polyoxyethylene (40) hydrogenated castor oil 0.2   Squalane 1   Glycerin 6   Ethyl alcohol 15   Carboxyvinyl polymer   (Carbopol 980, manufactured by B.F.GOODRICH) 0.7   Adipic acid 0.02   Potassium hydroxide 0.3   Paraoxybenzoate 0.3   Purified water balance

[0028] Example 5 (lotion)   Cedrol 0.1%   Asunaro extract (solid content 1.0%)   (50% 1,3 butylene glycol extract) 10   Yokuinin extract (solid content 0.3%)   (50% 1,3 butylene glycol extract) 5   Chamomile extract (solid content 1.7%)   (50% 1,3 butylene glycol extract) 12   Polyoxyethylene (60) hydrogenated castor oil 0.5   Dipropylene glycol 1.5   Glycerin 10   Tris (ethoxyethoxyethyl) phosphate 2   Acrylic acid / alkyl methacrylate copolymer 0.1   Potassium hydroxide 0.2   Succinic acid 0.1   Edetate disodium 0.02   Paraoxybenzoic acid ester 0.5   Purified water balance

[0029] Example 6 (cream)   Cedrol 0.2%   Clove extract (4.5% solids)   (50% ethyl alcohol extract) 1   Sorbitan monostearate 3.5   Cetyl alcohol 1.5   Stearyl alcohol 1   Polyoxyethylene (20) sorbitan monostearate 4   Cholesterol 0.8   Cholesteryl isostearate 0.5   Glycerin 20   Succinic acid 0.02   Sodium hydroxide 0.002   Paraoxybenzoic acid ester 0.2   Purified water balance

The cosmetics of Examples 2 to 5 had no irritation derived from the plant extract and the compounding concentration could be increased,
It has a remarkable effect on rough skin.

[0031]

INDUSTRIAL APPLICABILITY The present invention has an excellent effect of reducing skin irritation, and the external preparation for skin of the present invention can reduce the skin irritation of a plant extract and increase its content, such as acne. It has excellent effects of plant extracts such as reduction of rash, improvement of bulkiness and reduction of desquamation.

─────────────────────────────────────────────────── ─── Continuation of front page (51) Int.Cl. ⁷ Identification code FI theme code (reference) A61K 35/78 A61K 35/78 Q TUV 7/00 7/00 C K 31/045 31/045 A61P 17/00 A61P 17/00 (72) Inventor Toshio Uesaka 2-1-3 Fumika, Sumida-ku, Tokyo F-term inside the research institute of Kao Corporation (reference) 4C083 AA111 AA112 AA121 AA122 AB032 AC022 AC072 AC091 AC092 AC102 AC122 AC292 AC432 AC442 AC482 AC902 AD092 AD112 AD152 AD492 CC02 CC04 CC05 DD23 DD31 DD41 EE10 EE12 4C088 AB03 AB12 AB13 AB26 AB38 AB40 AB45 AB51 AB57 AB58 AB62 AB77 AB86 BA08 CA03 MA02 MA63 NA14 ZA89 4C206 AA01 AA02 CA09 MA01 MA02 MA14 MA11 MA83 MA14 MA14 MA11 MA83

Claims (5)

[Claims] 1. A stimulant for skin irritation caused by a plant extract comprising cedrol. 2. A skin external preparation containing the following components (A) and (B): (A) sedrol and (B) a plant extract. 3. The component (B) comprises asunaro, button pipi, tansou, carrot, horse chestnut, yuzu, aloe, sardine, peony, cha, toki, button, yokinin,
3. The external preparation for skin according to claim 2, which is an extract of a plant selected from the group consisting of oleander, psyllium, chamomile, clove, clam, hamamelis, thistle, altea, linden, and eucalyptus. 4. The external preparation for skin according to claim 2, which contains 0.001 to 10% by weight of the component (A). 5. The external skin preparation is a cosmetic composition.
The external preparation for skin according to any one of 1.