JP2003081797A - Composition for the oral cavity - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for the oral cavity including a sulfosuccinate based surfactant to effectively inhibit formation of stein and improving bitterness originating from the sulfosuccinate based surfactant and the odor of the surfactant. SOLUTION: This composition for the oral cavity comprises 0.01-5 wt.% of the sulfosuccinate based surfactant expressed by general formula (1), 0.01-1 wt.% of saccharin sodium and stevioside mixed in the weight ratio of saccharin sodium:stevioside=1:1 to 8:1, and one or more kinds of compound selected from vanillin, anethole and benzylsuccinate. [In the formula either one of X1 and X2 is R1 O-(AO)n or R1 CO-B-(AO)n - and the other is M2 O-, M1 and M2 are each same or different H, an alkali metal or the like, R1 is a 8-22C alkyl or alkenyl group, AO is a 2-3C oxyalkylene group, the average added mole numbers n is 0-20, B is -NH- or the like].

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an oral composition containing a sulfosuccinic acid surfactant.

[0002]

2. Description of the Related Art Stain is a pigment deposit on teeth that is thought to be caused by bactericides such as chlorhexidine, tannin-based substances contained in tea, etc., and metal ions such as iron. It's a problem. As a means for solving this, a method of removing stains and a method of inhibiting the formation of stains can be considered. Although strong abrasives and bleaches are generally used to remove stains, these have the problems of damaging the teeth and strong irritation. As a means to solve this,
Use of a sulfosuccinic acid-based surfactant as a stain formation inhibitor in an oral composition is disclosed in JP-A-10-17443.
It is disclosed in the publication. However, the sulfosuccinic acid-based surfactant has a strong bitterness and a strong odor of the active agent, and if it is simply added to the oral composition, the use feeling is significantly impaired.

In order to solve this problem, Japanese Patent Laid-Open No. 12-
Japanese Patent No. 53547 discloses that a water-soluble divalent metal salt is blended, but although bitterness is suppressed, a problem occurs in that the feeling of use such as foaming is impaired. JP 2
Japanese Patent Application Laid-Open No. 000-319148 discloses that palatinit is mixed, but there is a problem that the manufacturing cost increases. It should be noted that these patents do not mention the solution of the odor of the active agent.

[0004]

An object of the present invention is to incorporate a sulfosuccinic acid type surfactant in order to effectively inhibit stain formation, and to eliminate the bitterness and the odor of the active agent derived from the sulfosuccinic acid type surfactant. It is to provide an improved oral composition.

[0005]

[Means for Solving the Problems] In view of such a current situation,
As a result of intensive studies, the present inventors have found that saccharin sodium and stevioside are selected from vanillin, anethole, and benzyl succinate in a weight ratio of 1: 1 to 8: 1 in a total amount of 0.01 to 1% by weight. It was found that the bitterness and the odor of the active agent derived from the sulfosuccinic acid surfactant can be effectively suppressed by blending one or more kinds of the fragrance compounds described above, and the present invention has been completed. Item 1 0.01 to 5% by weight of at least one sulfosuccinic acid-based surfactant represented by the general formula (1), and sodium saccharin and stevioside in a weight ratio of 1: 1 to 8:
An oral composition containing 0.01 to 1% by weight in total of 1 and at least one selected from vanillin, anethole and benzyl succinate. General formula (1):

[0006]

[Chemical 2]

[Wherein _{one of} X ₁ and X ₂ is R ₁
O- (AO) _n - or _{R 1 CO-B- (AO)} n - is and the other is M ₂ O-, M ₁ and M ₂ are the same or different and each is hydrogen, an alkali metal, alkaline earth Represents a metal, ammonium or alkanolamine, R
₁ is an alkyl group or alkenyl group having 8 to 22 carbon atoms, AO is an oxyalkylene group having 2 to 3 carbon atoms, the average number of moles of addition n is 0 to 20, B is —NH— or 2 to 2 carbon atoms.
3 represents a monoalkanolamine residue of 3. Item 2 The oral composition according to Item 1, wherein the sulfosuccinic acid-based surfactant represented by the general formula (1) has an average number of added moles n of AO groups of 0 to 7. Item 3 The alkyl group or alkenyl group of the sulfosuccinic acid-based surfactant represented by the general formula (1) has 10 carbon atoms.
Item 14. The oral composition according to Item 1, which is -14. Item 4. The oral composition according to Item 1, wherein M ₁ and M ₂ of the sulfosuccinic acid-based surfactant represented by the general formula (1) are sodium.

[0008] Stevioside, vanillin, anethole and benzyl succinate may be mixed with a plant extract containing them.

[0009]

BEST MODE FOR CARRYING OUT THE INVENTION The sulfosuccinic acid surfactant used in the present invention is not particularly limited as long as it is a sulfosuccinic acid monoester represented by the general formula (1). General formula (1):

[0010]

[Chemical 3]

[Wherein _{one of} X ₁ and X ₂ is R ₁
O- (AO) _n - or _{R 1 CO-B- (AO)} n - is and the other is M ₂ O-, M ₁ and M ₂ are the same or different and each is hydrogen, an alkali metal, alkaline earth Represents a metal, ammonium or alkanolamine, R
₁ is an alkyl group or alkenyl group having 8 to 22 carbon atoms, AO is an oxyalkylene group having 2 to 3 carbon atoms, the average number of moles of addition n is 0 to 20, B is —NH— or 2 to 2 carbon atoms.
3 represents a monoalkanolamine residue of 3. ] In the sulfosuccinic acid monoester represented by the general formula (1), R ₁ is a naturally-occurring or synthesized carbon atom having 8 to 22 carbon atoms.
It is a straight-chain or branched alkyl group or alkenyl group to a degree. For example, lauryl, cocoyl, myristyl, stearyl, C ₁₂ -C ₁₄ synthetic alkyl, isononyl, isododecyl, octenyl, and the like Dodekeniru.
The longer the carbon number of R _1, the less bitterness and irritation, but the shorter the carbon number of R ₁ , the higher the effect of inhibiting stain formation. Therefore, the carbon number of R ₁ is preferably about 10 to 16, more preferably about 12 to 14. In particular, it is most preferable to use a combination of C _{12 to} C ₁₄ synthetic alkyl or lauryl and myristyl.

M ₁ and M _{2, which} may be the same or different, are hydrogen, alkali metal, alkaline earth metal, ammonium or alkanolamine. Examples of the alkali metal include sodium and potassium, examples of the alkaline earth metal include magnesium, and examples of the alkanolamine include monoethanolamine, diethanolamine, triethanolamine and the like.
Among these, as M ₁ and M ₂ , sodium and magnesium are more preferable, and sodium is particularly preferable.

The AO group is an oxyalkylene group having about 2 to 3 carbon atoms, preferably an oxyethylene group. The average addition mole number n of AO is preferably about 0 to 20. The smaller the average added mole number n, the higher the effect of inhibiting stain formation and the less bitterness. Therefore, n is preferably about 0 to 7, most preferably about 0 to 2. Here, the average added mole number of 0 means a sulfosuccinic acid monoester to which oxyalkylene is not added.

Examples of the sulfosuccinic acid monoester represented by the general formula (1) include polyoxyethylene (7 mol) disodium lauryl sulfosuccinate, polyoxyethylene (2 mol) disodium lauryl sulfosuccinate and polyoxyethylene ( 1 mol) disodium lauryl sulfosuccinate, disodium lauryl sulfosuccinate, polyoxyethylene (7 mol) disodium myristyl sulfosuccinate, polyoxyethylene (2 mol) alkyl (C12-14) disodium sulfosuccinate,
Polyoxyethylene (1 mol) alkyl (C12-1
4) Disodium sulfosuccinate, alkyl (C12-
14) Disodium sulfosuccinate, polyoxyethylene (2 mol) magnesium lauryl sulfosuccinate, polyoxyethylene (2 mol) alkyl (C12-14)
Magnesium sulfosuccinate, polyoxyethylene (7
Mol) myristyl sulfosuccinic acid 2 triethanolamine and the like. Examples of general formula (2) include oleic acid amide disodium sulfosuccinate, polyoxyethylene (5 mol) lauroylethanolamide disodium succinate, polyoxyethylene (2 mol) cocoylisopropanolamide disodium succinate, etc. Is mentioned.

Further, the most preferred sulfosuccinic acid monoeth
Tell is the same as R in the general formula (1). ₁Has 12 to 1 carbon atoms
Alkyl group of about 4 and AO group is an oxyethylene group
So, the average addition mole number n is about 0-2
It is salt. Specifically, polyoxyethylene (2 mol)
Alkyl (C12-14) sulfosuccinic acid 2 sodium
, Polyoxyethylene (1 mol) alkyl (C12-
14) Disodium sulfosuccinate, alkyl (C12
~ 14) disodium sulfosuccinate and the like can be mentioned.
It

The sulfosuccinic acid ester represented by the general formula (1) may be used alone or in combination of two or more kinds.

The amount of the sulfosuccinic acid monoester represented by the general formula (1) is usually preferably about 0.01 to 5% by weight, more preferably 0.1 to 2% by weight, based on the whole composition. %. 0.01% by weight
If the amount is less than the above range, a sufficient stain formation inhibiting effect cannot be obtained, and if it exceeds about 5% by weight, the feeling of use becomes poor.

The stevioside used in the present invention may be used as a single compound, or may be blended as a plant extract containing stevioside (eg stevia extract).

Sodium saccharin and stevioside are mixed in a weight ratio of 1: 1 to 8: 1, and are added so that the total amount is 0.01 to 1% by weight based on the total weight of the composition. Saccharin sodium or stevioside alone cannot provide a sufficient bitterness suppressing effect. Weight ratio is 1: 1
Less than (1 part by weight of stevioside less than 1 part by weight of saccharin sodium) or more than 8: 1 (1 part by weight of stevioside contains 8 parts by weight of saccharin sodium).
When it exceeds the weight part), there is no sufficient bitterness improving effect. Also,
If the total is less than 0.01%, a sufficient bitterness-suppressing effect cannot be obtained, and if the total exceeds 1%, the sweetness is too strong and there is a problem in the feeling of use.

The preferred blending ratio of sodium saccharin and stevioside is about 1: 1 to 4: 1. Further, the preferable blending amount of saccharin sodium and stevioside is preferably such that the total amount of saccharin sodium and stevioside is about 0.02 to 0.5% by weight based on the total weight of the composition.

With respect to vanillin, anethole, and benzyl succinate, when at least one selected from these is blended, the odor of the active agent of the sulfosuccinic acid type surfactant is masked. Although vanillin, anethole, and benzyl succinate may be used as a single compound, they may be mixed as a plant extract containing essential oils containing them. Examples of such plant extracts include vanilla oil and clove oil as essential oils containing vanillin, anise oil as essential oils containing anethole, star anise oil, fennel oil and the like, and essential oils containing benzyl succinate. Examples include cranberry oil.

The blending amount of at least one of vanillin, anethole and benzyl succinate is usually about 0.0001 to 1% by weight, preferably about 0.001 to 0.5% by weight, based on the whole composition. More preferably 0.0
It is about 01 to 0.2% by weight.

The oral composition for inhibiting stain formation of the present invention comprises a powder toothpaste, a toothpaste, a gel, a pre-paste, a pasta, a liquid toothpaste, a mouthwash, a chewing gum, a dental floss, a patch, a sealant, and Although it can be made into a dosage form such as a tablet, dentifrice, liquid dentifrice,
Alternatively, a mouthwash is particularly preferable.

In the oral composition of the present invention, in addition to the sulfosuccinic acid type surfactant, saccharin, stevioside, vanillin, anethole and benzyl succinate, water,
Lower alcohols, higher alcohols and additives usually used in the art can be appropriately blended depending on the dosage form and the like. Examples of such additives include abrasives, excipients, foaming agents, fragrances other than vanillin, anethole and benzyl succinate, sweeteners other than saccharin and stevioside, binders, pH adjusters, wetting agents, preservatives. , A colorant, various medicinal components and the like can be added within a range that does not impair the effects of the invention.

The amount of water to be added can be appropriately set depending on the dosage form and the like, but is usually 0 to 90 relative to the whole composition.
It is about% by weight, preferably about 10 to 85%. The amount of the lower alcohol compounded is usually about 0 to 20% by weight, preferably about 0 to 10%, based on the entire composition. The amount of higher alcohol is usually 0 to 70% by weight based on the whole composition.
The degree is about 5 to 50%.

For example, in a dentifrice, a second abrasive is used as an abrasive.
Calcium phosphate dihydrate and anhydrate, calcium phosphate, tertiary calcium phosphate, calcium carbonate, calcium pyrophosphate, aluminum hydroxide, alumina,
Silica gel, aluminum silicate, precipitable silica, insoluble sodium metaphosphate, tribasic magnesium phosphate, magnesium carbonate, calcium sulfate, polymethyl methacrylate, bentonite, zirconium silicate, hydroxyapatite, synthetic resin and the like can be used. These abrasives may be used alone or in combination of two or more, and the compounding amount thereof is usually 5 to 9 relative to the total weight of the composition.
It is about 0% by weight, and in the case of toothpaste, it is about 5 to 50% by weight.

Examples of the excipient include ignitable silica, thickening silica (generally, silica having an RDA value of about 30 or less), powdery cellulose containing crystalline cellulose and the like. Of these, pyrogenic silica and thickening silica are preferable. The amount of the excipient to be added is usually about 0.1 to 30% by weight, preferably about 0.5 to 10% by weight, based on the total weight of the composition.

Examples of the foaming agent include anionic surfactants other than the sulfosuccinic acid type surfactant represented by the general formula (1). For example, the number of carbon atoms of the alkyl group such as sodium lauryl sulfate and sodium myristyl sulfate is 8 to 1.
8 higher alkyl sulfate ester salt; N-long chain acyl amino acid salt, α-olefin sulfonate salt, higher fatty acid sodium monoglyceride monosulfate, N-
Methyl-N-palmitoilide salt, N-acyl sarcosine sodium, N-acyl glutamate, N-
Methyl-N-acyl taurine sodium, N-methyl-
Anionic surfactants such as sodium N-acylalanine and sodium α-olefinsulfonate can be exemplified. Many of these anionic surfactants have a high stain-removing effect by chemical dissolution, and it is particularly preferable to add sodium lauryl sulfate because the stain formation-inhibiting effect is synergistically enhanced. These anionic surfactants may be used alone or in combination of two or more kinds. The amount of the anionic surfactant other than the sulfosuccinic acid-based surfactant represented by the general formula (1) is usually about 0.001 to 5% by weight, preferably 0.01 to 5% by weight based on the whole composition. It is about 2% by weight.

In addition to the anionic surfactant, an amphoteric surfactant, a cationic surfactant or a nonionic surfactant usually used in oral compositions may be added.
Examples of such surfactants include polyoxyethylene sorbitan monolaurate and other polyoxyethylene sorbitan fatty acid esters such as polyoxyethylene fatty acid esters, polyoxyethylene hydrogenated castor oil, lauric acid monoethanolamide, myristic acid monoester. Ethanolamide, polyoxyethylene higher alcohol ether, polyoxyethylene polyoxypropylene copolymer, polyoxyethylene polyoxypropylene fatty acid ester alkyl glycoside (for example, alkyl chain: C8-
C16), polyglycerin fatty acid ester (for example, fatty acid part alkyl chain: C8 to C16), sucrose fatty acid ester (for example, fatty acid part alkyl chain: C8-
Nonionic surfactants such as C16) and the like; N-alkyldiaminoethylglycine, alkylbetaine, fatty acid amidopropylbetaine (for example, alkyl chain of fatty acid part: C8 to C16), alkylsulfobetaine, alkylbetaine imidazolium betaine, etc. And amphoteric surfactants such as: alkyl trimethyl ammonium chloride, alkyl trimethyl ammonium bromide, alkyl dimethyl ammonium chloride, and other cationic surfactants. Of these, polyoxyethylene hydrogenated castor oil and alkyl glycosides are preferable.

The amount of the sulfosuccinic acid-based surfactant represented by the general formula (1) and the surfactant excluding the anionic surfactant is usually about 0.001 to 5% by weight based on the whole composition, It is preferably about 0.01 to 2% by weight.

Examples of the binder include cellulose derivatives such as sodium carboxymethyl cellulose; alkali metal alginates such as sodium alginate; gums such as propylene glycol alginate ester, xanthan gum, tragacanth gum, karaya gum, gum arabic, and carrageenan; polyvinyl alcohol, polyacryl. Examples thereof include synthetic binders such as sodium acidate, carboxyvinyl polymer, and polyvinylpyrrolidone. The binder may be used alone or in combination of two or more kinds. The compounding amount thereof is usually about 0.3 to 5% by weight based on the whole composition.

Fragrances other than vanillin, anethole and benzyl succinate include menthol, carvone, eugenol, methyl salicylate, limonene, ocimene,
n-decyl alcohol, citronellol, α-terpineol, methyl acetate, citronellyl acetate,
Examples thereof include methyl eugenol, sionel, linalool, ethyl linalool, vanillin and thymol. These may be used as a single compound, but may also be blended as a plant extract liquid such as an essential oil containing them. Also, as fragrances, thyme oil, nutmeg oil, spearmint oil, peppermint oil, lemon oil, orange oil,
Examples include sage oil, rosemary oil, cinnamon oil, pimento oil, diatom oil, perilla oil, wintergreen oil, eucalyptus oil, basil oil, tea tree oil, and tabana oil. The fragrances may be used alone or in combination of two or more. The blending amount of the fragrance other than vanillin, anethole and benzyl succinate is usually about 0.05 to 10% by weight, preferably about 0.1 to 5% by weight, based on the entire composition.

Examples of sweeteners other than sodium saccharin and stevioside include sweeteners such as acesulfame K, glycyrrhizin, perillartin, taumatine, aspartylphenylalanine methyl ester, xylitol, palatinose, palatinit, erythritol and maltitol. The sweetener can be used alone or 2
You may use together 1 or more types. The amount of the sweetening agent other than sodium saccharin and stevioside is usually about 0.01 to 5% by weight based on the entire composition.

As the wetting agent, for example, sorbit solution,
Examples thereof include glycerin, ethylene glycol, propylene glycol, 1,3-butylene glycol, polyethylene glycol, polypropylene glycol and lactit. The wetting agent may be used alone or in combination of two or more kinds, and the compounding amount thereof is usually 5 to the whole composition.
It is about 70% by weight.

Examples of the pH adjuster include phosphoric acid and its salts (sodium phosphate, sodium hydrogen phosphate, etc.), citric acid and its salts (sodium, etc.), phosphoric acid and its salts, malic acid and its salts, Gluconic acid and its salts, maleic acid and its salts, aspartic acid and its salts, gluconic acid and its salts, succinic acid and its salts, glucuronic acid and its salts, fumaric acid and its salts, glutamic acid and its salts, adipic acid and Examples thereof include salts thereof, hydrochloric acid, sodium hydroxide, potassium hydroxide, sodium silicate and the like. The pH adjuster is
They may be used alone or in combination of two or more. The compounding amount of the pH adjuster is not particularly limited as long as it has a desired pH, but is usually about 0.01 to 5% by weight, preferably about 0.1 to 3% by weight, based on the entire composition. The pH of the composition of the present invention is not particularly limited as long as the effects of the present invention are exhibited, but is usually 4
It is about 10 and preferably about 5.5-9.

Examples of preservatives include benzoates such as sodium benzoate; parabens such as methylparaben and butylparaben. The preservatives may be used alone or in combination of two or more. The content of the preservative is usually about 0.01 to 3% by weight based on the whole composition.

Examples of the colorant include legal dyes such as Blue No. 1, Yellow No. 4, Red No. 202 and Green No. 3; mineral dyes such as ultramarine blue, reinforced ultramarine blue and dark blue; titanium oxide and the like. it can. The colorants may be used alone or in combination of two or more. The amount of the colorant compounded is usually about 0.0001 to 1% by weight based on the entire composition.

Examples of the medicinal component include quaternary ammonium salts such as cetylpyridinium chloride, benzethonium chloride, distearyldimethylammonium chloride, stearyldimethylbenzylammonium chloride, stearyltrimethylammonium chloride, lauryltrimethylammonium chloride and laurylpyridinium chloride, Cationic fungicides such as biguanide fungicides such as chlorhexidine hydrochloride, chlorhexidine acetate, chlorhexidine gluconate, alexidine hydrochloride, alexidine acetate and alexidine gluconate; anionic bactericides such as sodium n-lauroyl sarconcin; triclosan, isopropylmethylphenol Non-ionic fungicides such as dextranase, amylase, papain, protease, mutanase, lysozyme, lysate Enzymes such as enzymes (Litech Enzyme); zinc compounds such as zinc oxide and zinc chloride; alkali metal monofluorophosphates such as sodium monofluorophosphate and potassium monofluorophosphate; fluorine such as sodium fluoride and stannous fluoride. Compounds, tranexamic acid, epsilon aminocaproic acid, aluminum chlorhydroxyl allantoin, dihydrocholesterol, vitamin E derivatives such as tocopherol acetate, glycyrrhizin salts, glycyrrhetinic acid, glycerophosphate, chlorophyll, potassium nitrate, sodium chloride,
Caropeptides, water-soluble inorganic phosphate compounds and the like can be mentioned.

The water-soluble inorganic phosphoric acid compound is represented by the general formula (2): M _{m + 2} P _m O _{3m + 1} [wherein M represents Na or K, and m is an integer of 2 or more]. General formula (3): (MPO ₃ ) _l [In the formula, M represents Na or K, and l is an integer of 3 or more. ] The compound represented by these is illustrated.

M is usually an integer of 2 or more, preferably about 2 to 6. l is usually an integer of 3 or more, preferably about 3 to 6.

Specific examples of the compound represented by the formula (2) include sodium pyrophosphate, potassium pyrophosphate, sodium tripolyphosphate and the like.

Specific examples of the compound represented by the formula (3) include sodium tetrametaphosphate and sodium hexametaphosphate.

The active ingredients may be used alone or in combination of two or more kinds. The compounding amount of the active ingredient is not particularly limited as long as it is within a range in which a desired effect is obtained, and can be appropriately set according to the kind of the active ingredient. The content of the active ingredient is usually about 0.001 to 30% by weight, preferably about 0.01 to 20% by weight, based on the entire composition.

[0044]

The present invention will be described in more detail below with reference to examples, but the present invention is not limited thereto. In addition, unless otherwise specified, [%] indicates [% by weight].

The components shown below were blended and a toothpaste was prepared according to a conventional method and used for evaluation.

Examples 1 to 4 and Comparative Examples 1 to 4 Formulation components Thickening silica 5.0 Precipitating silica 18.0 Solbit solution (70%) 35.0 Sulfosuccinic acid type surfactant Saccharin sodium shown in Table 1 Stevioside as shown in Table 1 Triclosan 0.1 Carboxymethylcellulose sodium 1.0 Vanillin as shown in Table 1 Anethole as shown in Table 1 Benzyl succinate as shown in Table 1 Perfume 0.9 as shown in Table 1 Water balance 100.0 Evaluation method (bitterness The evaluation of bitterness was carried out by evaluating the degree of bitterness when brushing teeth with the test dentifrice on a scale of 5 points. 1 point: No activator odor is felt, 2 points: Almost no activator odor is felt, 3
Point: Slight activator odor, 4 point: Activator odor,
5 points: Very strong odor of the active agent is felt.

Evaluation points of 5 panelists were added, and 5 points or more and 10 points or less were evaluated as O, 11 points or more and 15 points or less Δ, and 16 points or more were evaluated as X. The higher the score, the stronger the bitterness. (Evaluation of Active Agent Odor) The evaluation of the active agent odor was made by evaluating the degree of odor when brushing teeth with the test dentifrice on a scale of 5 points. 1
Points: No active agent odor is felt, 2 points: Almost no active agent odor is felt, 3 points: A little active agent odor is felt, 4 points: Active agent odor is felt, 5 points: Active agent odor is felt very strongly. .

Evaluation points of 5 panelists were added, and 5 points or more and 10 points or less were evaluated as O, 11 points or more and 15 points or less Δ, and 16 points or more were evaluated as X. The higher the score, the stronger the activator odor.

The results of these evaluations are shown in Table 1.

[0050]

[Table 1]

As shown in Table 1, sodium saccharin and stevia extract were mixed in a weight ratio of 1: 1 to 8: 1 of 0.01.
% Or more and less than 1%, and one or two selected from vanillin, anethole and benzyl succinate.
When more than one flavor compound was added, the bitterness was low and the active agent odor was low. In addition, inhibition of stain formation was observed in all of the dentifrices of Examples 1 to 4.

Example 5 A toothpaste was prepared according to a conventional method according to the following formulation.       Ingredient amount (%)       Calcium carbonate 30.0       Thickening silica 3.0       Sorbit solution (70%) 30.0       Carboxymethyl cellulose sodium 1.0       Sodium lauryl sulfate 1.2       Disodium lauryl sulfosuccinate 2.0       n-Lauroyl sarcosine sodium 0.1        Fragrance 0.9       Vanilla oil (containing vanillin) 0.01       Anethole 0.05       Benzyl succinate 0.01       Saccharin sodium 0.2       Stevia extract (70% Stevioside) 0.04       Remaining water       100.0 in total

Example 6 A toothpaste was prepared according to a conventional method according to the following formulation.       Ingredient amount (%)     Thickening silica 5.0     Precipitating silica 15.0     Sorbit solution (70%) 30.0     Glycerin 10.0     Titanium oxide 0.5     Polyethylene glycol 400 3.0     Carboxymethyl cellulose sodium 1.0     Sodium lauryl sulfate 1.0     Polyoxyethylene (60) hydrogenated castor oil 1.0     Polyoxyethylene (2 mol) alkyl     (12-14) Disodium sulfosuccinate 1.0     Sodium fluoride 0.2     Isopropyl methylphenol 0.05     Fragrance 0.9     Vanillin 0.02     Star anise oil (containing anethole) 0.03     Saccharin sodium 0.2     Stevia extract (Stebioside 50%) 0.1     Remaining water     100.0 in total

Example 7 A mouthwash was prepared according to a conventional method according to the following formulation.       Ingredient amount (%)       Glycerin 10.0       Ethanol 8.0       Polyoxyethylene (60) hydrogenated castor oil 0.5       Fragrance 0.3       Vanillin 0.01       Benzyl succinate 0.01       Saccharin sodium 0.03       Stevioside 0.01       Polyoxyethylene (1 mol) lauryl       Disodium sulfosuccinate 0.3       Remaining water       100.0 in total

Example 8 A liquid dentifrice was prepared according to a conventional method according to the following formulation. Ingredients Amount (%) Glycerin 10.0 Ethanol 7.0 Polyoxyethylene (60) Hydrogenated castor oil 0.5 Propylene glycol 5.0 Polyethylene glycol 1.0 Perfume 0.2 Fennel oil (containing anethole) 0.01 Saccharin sodium 0.1 Stevioside 0.02 Disodium lauryl sulfosuccinate 0.4 Cetylpyridinium chloride 0.02 Water balance 100.0 The oral compositions prepared according to Examples 5, 6, 7 and 8 also showed stain formation. Inhibition was observed, and further suppression of bitterness and active agent odor was observed.

[0056]

EFFECTS OF THE INVENTION According to the present invention, there is provided an oral composition capable of maintaining an aesthetically excellent tooth by effectively inhibiting stain formation and having an excellent feeling of use without bitterness or active agent odor. Can be provided.

Continued front page    F-term (reference) 4C083 AA122 AB172 AB242 AB472                       AC102 AC122 AC132 AC171                       AC172 AC211 AC212 AC341                       AC342 AC472 AC662 AC692                       AC782 AC791 AC792 AC812                       AC861 AC862 AD042 AD272                       AD391 AD392 CC41 DD22                       DD23 DD27 EE06 EE07 EE35

Claims (4)

[Claims] 1. 0.01 to 5% by weight of at least one sulfosuccinic acid-based surfactant represented by the general formula (1),
Saccharin sodium and stevioside in a weight ratio of 1:
An oral composition containing 0.01 to 1% by weight in a ratio of 1 to 8: 1 and at least one selected from vanillin, anethole and benzyl succinate. General formula (1): [In the formula, _one of X ₁ and X ₂ is R ₁ O— (AO) _n
- or _{R 1 CO-B- (AO)} n - is and the other is M ₂
O-, M ₁ and M ₂ are the same or different and each represent hydrogen, an alkali metal, an alkaline earth metal, ammonium or an alkanolamine, and R ₁ has 8 to 8 carbon atoms.
22 alkyl groups or alkenyl groups, AO is an oxyalkylene group having 2 to 3 carbon atoms, and the average number n of added moles is 0.
20, B represents -NH- or a monoalkanolamine residue having 2 to 3 carbon atoms. ] 2. The oral composition according to claim 1, wherein the sulfosuccinic acid-based surfactant represented by the general formula (1) has an average number of added moles n of AO groups of 0 to 7. 3. The oral composition according to claim 1, wherein the alkyl group or the alkenyl group of the sulfosuccinic acid-based surfactant represented by the general formula (1) has 10 to 14 carbon atoms. 4. The oral composition according to claim ₁ , wherein M ₁ and M ₂ of the sulfosuccinic acid-based surfactant represented by the general formula (1) are sodium.