JP2003063938A - Toothpaste composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a toothpaste composition that has high formative property on a toothbrush, keeps softened state allowing easy penetration into a narrow crevice of the mouth, and has excellent dispersibility in the mouth. SOLUTION: This toothpaste composition holds a viscosity curb of δ<1/2> =k0 +k1 γ<1/2> (wherein, δ represents a shearing stress; γ represents a shearing speed; k0 and k1 are each a constant; (k0 )<2> represents a yield stress; and (k1 )<2> represents a plastic viscosity}, having (k0 )<2> of 80 to 400 Pa and (k1 )<2> of 10 Pa.s or less}.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to a toothpaste having a high moldability on a toothbrush, a soft kneading state that allows easy entry into a narrow gap in the oral cavity, and an excellent dispersibility in the oral cavity. It relates to a composition.

[0002]

BACKGROUND OF THE INVENTION Toothpaste is required to have excellent moldability on a toothbrush as one of its basic functions because it requires an operation of taking it from a container onto the toothbrush in use. To be On the other hand, as a means to make the dentifrice function more effectively in a short brushing time, it is said that it is more effective for each ingredient such as the active ingredient and the cleaning ingredient to spread quickly into the oral cavity and spread to every corner. It also needs to be excellent. From this point of view, Japanese Patent Laid-Open Nos. 10-45549 and 10-17445 have been proposed as dentifrices having high dispersibility, but dentifrices having a low viscosity have been proposed to ensure dispersibility. However, the moldability equivalent to that of general dentifrice is not obtained. Further, there is known a technique for obtaining an excellent feeling of use by defining the rheological properties of the dentifrice (Japanese Patent No. 3120881 and Japanese Patent Application Laid-Open No. 8-175942). It was not enough to quickly spread into the oral cavity and spread to every corner.

The present invention has been made in view of the above circumstances.
An object of the present invention is to provide a toothpaste composition which is excellent in moldability on a toothbrush and quickly spreads in the oral cavity and can easily penetrate into an interdental part or a narrow gap between a tooth and a gum.

[0004]

Means for Solving the Problems and Modes for Carrying Out the Invention The inventors of the present invention have made extensive studies as a result of achieving the above object, and as a result, as a rheological property of a toothpaste composition, the following viscosity curve σ ^1/2 = K ₀ + k ₁ γ ^1/2 (where σ is shear stress, γ is shear rate, k ₀ and k ₁ are constants, (k ₀ ) ² is yield stress, and (k ₁ ) ² is plastic viscosity. (Corresponding to each other), (k ₀ ) ^{2 is set} to 80 Pa or more and 400 Pa or less, and (k ₁ ) ^{2 is set} to 10 Pa · s or less, and thus the plastic viscosity of the toothpaste composition is reduced, whereby the toothpaste composition It was found that the toothpaste component can act effectively even before entering the narrow gap and sufficiently dispersing in saliva.

That is, in order to ensure a high cleaning effect and an excellent effect of the active ingredient, the toothpaste composition can easily enter the interdental part or the narrow gap between the tooth and the gum by light brushing. It has been found that it is important not only to prepare a toothpaste composition, but also to be a soft toothpaste that easily penetrates into a narrow gap by brushing. In a conventional toothpaste composition having a high plastic viscosity, the toothpaste composition does not reach a narrow gap sufficiently because the toothpaste composition is harder than the stress in brushing in a stage before being sufficiently dispersed in saliva, I could not bring out the effect. However, when a soft toothpaste composition is simply used, there is a problem that the ease of putting the toothpaste on the toothbrush becomes poor and the feeling of use is unsatisfactory. Therefore, it is necessary to define the plastic viscosity as a very characteristic kneading property that has the same moldability as a normal toothpaste composition on a toothbrush but sharply decreases the kneading hardness when stress is applied by brushing. In order to facilitate the penetration of the toothpaste composition into every corner of the gap, and to regulate the yield stress to ensure the ease of collapsing and high dispersibility of the paste, the object of the present invention is to be solved. It was And
Thus intensive result of extensive investigations, the viscosity curve _{^{σ 1/2 = k 0 +}} k 1 γ 1/2 by the above formula Casson, (k
₀ ) ² is 80 Pa or more and 400 Pa or less, (k ₁ ) ² is 10 P
By using a toothpaste composition of a · s or less, the moldability on the toothbrush, the softness of the paste that easily penetrates into every corner, and the high dispersibility in saliva are secured, and the present invention is achieved. It is a thing.

The present invention will be described in more detail below.
The toothpaste composition of the present invention, like the conventional toothpaste composition,
Containing an abrasive, a thickener, a binder, a surfactant, and if necessary, a sweetener, an antiseptic, an active ingredient, a dye, a fragrance, etc., and kneading these ingredients with water. Is.

In this case, the polishing agent is silica gel,
Silica-based abrasives such as precipitated silica, pyrogenic silica, aluminosilicate and zirconosilicate, dicalcium phosphate dihydrate, dicalcium phosphate anhydrous, calcium pyrophosphate, aluminum hydroxide, alumina, 2
Titanium oxide, crystalline zirconium silicate, polymethylmethacrylate, insoluble calcium metaphosphate, light calcium carbonate, heavy calcium carbonate, magnesium carbonate, magnesium triphosphate, zeolite, zirconium silicate, hydroxyapatite, fluoroapatite, calcium-deficient apatite, Examples include tricalcium phosphate, quaternary calcium phosphate, octocalcium phosphate, synthetic resin-based abrasives, and the like. Among these, a silica-based abrasive can obtain more excellent dispersibility. The content of the abrasive is 10 to 50% (mass percentage,
The same applies hereinafter), particularly preferably 15 to 40%.

As the thickener, one kind or two or more kinds of glycerin, sorbit, propylene glycol, polyethylene glycol having a molecular weight of 200 to 6000, ethylene glycol, polyhydric alcohol such as saccharified reduced starch and the like can be used, and their blending is possible. The amount is 10-40 of the total composition.
%, Particularly 20 to 30% is preferable.

Examples of the binder include sodium polyacrylate, xanthan gum, sodium alginate, propylene glycol alginate, carboxymethyl cellulose, polyvinyl alcohol, hydroxyethyl cellulose, carrageenan, carbopol, guar gum, gelatin, Avicel, montmorillonite, kaolin and bentonite. Inorganic binders and the like can be used, and they can be blended within a range that does not impair the characteristics of the present invention, but usually 0.5 to 2.0%, particularly 1.0 to 1.5% of the entire composition.
% Is preferred.

Examples of the surface active agent include an anionic surface active agent, a cationic surface active agent, a nonionic surface active agent, and the like. Specifically, sodium lauryl sulfate, sodium N-lauroyltaurine, N-acyl sarcosinate,
α-Sodium olefin sulfonate, N-acyl glutamate, 2-alkyl-N-carboxymethyl-N-
Examples thereof include hydroxyethyl imidazolinium betaine, N-acyl taurate, sucrose fatty acid ester, alkylol amide, polyoxyethylene sorbitan monostearate, pluronic, and decaglyceryl laurate. Good dispersibility can be obtained by adjusting the total amount of these surfactants to be 0.5 to 5% of the total composition.

As the sweetener, saccharin sodium,
As preservatives such as asparatame, stevioside, stevia extract, paramethoxycinnamic aldehyde, neohesperidyl dihydrochalcone, perillartine, etc.,
Parabens such as butyl paraben and ethyl paraben, paraoxybenzoic acid ester, sodium benzoate and the like can be mentioned.

Various active ingredients include various anti-inflammatory agents, fluorides such as sodium fluoride, potassium fluoride, stannous fluoride, strontium fluoride, and sodium monofluorophosphate, potassium salts of orthophosphoric acid, and sodium. Water-soluble phosphate compounds such as salts, allantoin chlorohydroxyaluminum, hinokitiol, ascorbic acid, lysozyme chloride, glycyrrhizic acid and its salts, sodium chloride, dl-tocopherol acetate, dihydrocholesterol, α-bisabolol, isopropylmethylphenol, chlorhexidine salts, Triclosan, biosol, cetylpyridinium chloride, azulene, glycyrrhetin, glycyrrhetinic acid, copper chlorophyllin sodium,
Chlorophyll, chelating phosphate compounds such as glycerophosphate, copper compounds such as copper gluconate, aluminum lactate, strontium chloride, potassium nitrate, berberine, hydroxamic acid and its derivatives, sodium tripolyphosphate, zeolite, methoxyethylene, maleic anhydride co-polyester Extracts of coalesced, polyvinylpyrrolidone, epidihydrocholesterin, benzethonium chloride, sodium chloride, dihydrocholesterol, trichlorocarbanilide, zinc citrate, soft-towberry extract, buckthorn extract, chamomile, clove, rosemary, sorghum, safflower, etc. Is mentioned.

As the fragrance, peppermint oil, spearmint oil, anise oil, eucalyptus oil, wintergreen oil, cassia oil, clove oil, thyme oil, sage oil, lemon oil, orange oil, peppermint oil, cardamom oil, coriander oil, Mandarin oil, lime oil, lavender oil, rosemary oil, laurel oil, chamomile oil, caraway oil, marjoram oil, bay oil, lemongrass oil, origanum oil, pine needle oil, neroli oil, rose oil, jasmine oil, iris Natural fragrances such as concrete, absolute peppermint, absolute rose, orange flower, etc. and processing of these natural fragrances (pre-drain cut,
After-cutting fraction cut, fractionation, liquid-liquid extraction, essence, powdered fragrance, etc.), and menthol, carvone, anethole, cineol, methyl salicylate, cinnamic aldehyde, eugenol, 3,1-menthoxypropane- 1,2-diol, thymol, linalool, linalyl acetate, limonene, menthone, menthyl acetate, N-substituted-paramenthane-3-carboxamide,
Pinene, octyl aldehyde, citral, pulegone,
Carbyl acetate, anisaldehyde, ethyl acetate, ethyl butyrate, allyl cyclohexane propionate, methyl anthranilate, ethylmethylphenylglycidate, vanillin, undecalactone, hexanal, ethyl alcohol, propyl alcohol,
Butanol, isoamyl alcohol, hexenol, dimethyl sulfide, cyclotene, furfural, trimethylpyrazine, ethyl lactate, ethyl thioacetate and other single fragrances, further, strawberry flavor, apple flavor, banana flavor, pineapple flavor, grape flavor, mango flavor,
Known perfume materials used in toothpaste compositions such as butter flavors, milk flavors, fruit mix flavors and tropical fruit flavors can be used, without being limited to the perfume of the examples.

The amount of the fragrance material is not particularly limited, but it is preferable to use 0.000001 to 1% of the fragrance material in the pharmaceutical composition. Further, as the perfume for perfuming using the above-mentioned perfume material, it is preferable to use 0.1 to 2% in the formulation composition.

Examples of colorants include Blue No. 1, Yellow No. 4, Green No. 3, and the like. The blending amount of these components is
A usual amount can be used within a range that does not impair the effects of the present invention.

The toothpaste composition of the present invention can be prepared by using the above components in appropriate amounts. In the present invention, the viscosity curve σ ^1/2 = k ₀ + k ₁ γ shown below is used as its rheological property.
^1/2 (where σ is shear stress, γ is shear rate, k ₀ and k ₁ are constants, (k ₀ ) ² corresponds to yield stress, and (k ₁ ) ² corresponds to plastic viscosity). , (K ₀ ) ² is 80 Pa
It is 400 Pa or less, and (k ₁ ) ² is 10 Pa · s or less.

That is, the yield stress (k ₀ ) ² is 80 Pa or more 4
It is important that the pressure is 00 Pa or less in order to secure moldability and dispersibility of the kneading, and more preferably 100 Pa or more and 25
It is 0 Pa or less. If it is less than 80 Pa, sufficient kneadability may not be obtained, and the ease with which it can be taken up on the toothbrush may deteriorate. If it exceeds 400 Pa, the toothpaste may not collapse easily and the dispersibility in saliva may deteriorate.

On the other hand, when the plastic viscosity (k ₁ ) ² exceeds 10 Pa · s, the hardness of the kneading mixture during brushing becomes strong, and the toothpaste composition has a low penetration property into a narrow interdental part or a gap between a tooth and a gum. become worse. More preferable plastic viscosity (k ₁ ) ² is _{1 to 10} Pa.
s, particularly preferably 3 to 9 Pa · s.

The toothpaste composition having such rheological properties may be prepared by using any of the components generally contained in the dentifrice composition. The present inventors have surprisingly found that a toothpaste composition having a high yield stress and an extremely small plastic viscosity can be formulated by incorporating a specific amount of a specific polyacrylic acid into a binder.

In this case, for example, as the thickening silica, Tokuseal GU-N manufactured by Tokuyama Soda Co., Ltd. is used in an amount of 3-5.
%, Rheozic 250H (Nippon Pure Chemicals Co., Ltd.) in sodium polyacrylate to be added as a binder is 0.6% or more, preferably 0.7% or more and 50% of the total amount of the binder.
By blending as described above, the rheological properties of the present invention can be obtained. Since polyacrylic acid has a high content of carboxyl groups in the unit molecular weight, it has high pH sensitivity, and when the pH of the composition is less than 6.0, the function as a binder is remarkably reduced and the yield stress is reduced. Therefore, the pH of the composition is preferably 6.5 or higher, more preferably 7.0 or higher. The pH of the composition
Is preferably 10 or less in terms of usability.

Further, it is useful to set the content of water-insoluble solid components such as abrasives to 25% or less to increase the proportion of liquid phase including the wetting agent, and to reduce the amount of the abrasive compounded, a high cleaning power is required. It is preferable to combine abrasive silica and thickening silica, and usually mix them in an amount of 15 to 25% (thickening silica of 3 to 5%). In addition, the ratio of anionic surfactant such as sodium lauryl sulfate is 90% as the surfactant.
As described above, it is effective to set it to 100%. When a large amount of a nonionic surfactant or the like is used in combination, the viscosity may increase due to a change in the phase behavior such as mixed micelle formation of the surfactant, and the desired rheological properties may not be obtained.

The toothpaste composition of the present invention contains the anti-inflammatory agent, which is an active ingredient used for the prevention of periodontal disease, because the toothpaste component easily enters the gap between the narrow tooth and the gum. Since it acts on the affected area before being diluted with saliva, an excellent anti-inflammatory effect can be imparted.

The anti-inflammatory agent as used herein is a non-steroidal anti-inflammatory agent, and examples thereof include acidic non-steroidal anti-inflammatory agents such as ibuprofen, indomethacin and aspirin, and basic non-steroidal anti-inflammatory agents such as tiaramide and timolidine. , Lysozyme chloride, semi-alkaline proteinase,
Anti-inflammatory enzyme agents such as trypsin, ε-aminocaproic acid,
Examples include antiplasmin agents such as tranexamic acid. Above all, an antiplasmin agent is suitable because of the storage stability of the toothpaste composition. The blending amount of these anti-inflammatory agents is an effective amount, preferably 0.001 to 2.0%, particularly 0.00
It is 5 to 1.0%.

In the toothpaste composition of the present invention, B
The viscosity at 25 rpm measured by an H-type viscometer is 400 to 1000 Pa · s, especially 550 to 850 Pa at 20 rpm.
-S is preferable.

[0025]

EFFECTS OF THE INVENTION The toothpaste composition of the present invention has high moldability on a toothbrush, has a soft kneading state that allows easy entry into narrow gaps in the oral cavity, and has excellent oral dispersibility. It is a thing.

[0026]

EXAMPLES The present invention will be specifically described below by showing Examples and Comparative Examples, but the present invention is not limited to the following Examples. In addition, unless otherwise indicated,% indicates a mass percentage. [Evaluation Method] (1) Rheological Property: ReoStress RS50
(HAAKE) using a cone plate type sensor (D = 60 mm, 4 °) at 25 ° C. and a shear rate of 0 to
Measured at 10 sec ^-1, C in 0.3～1.5Sec ^-1
Viscosity curve σ ^1/2 = k ₀ + k _{1 according} to Asson's plot
Fitting to γ ^1/2 , yield stress (k ₀ ) ² , plastic viscosity (k ₁ )
I asked for ² . (2) Moldability: The sample was filled in a container having an inner diameter of 6 mm in the mouth portion, and evaluated by the shape change when 0.5 g was placed on the toothbrush. 5: No deformation on the toothbrush is observed. 4: A slight deformation on the toothbrush is observed. 3: Gradually lose its shape on the toothbrush. 2: Immediately loses its shape on the toothbrush. 1: There is no moldability on the toothbrush. (3) Ease of entry into the gap of toothpaste: A sample having a mouth diameter of 6 mm was filled with the sample, and 0.5 g was placed on the toothbrush, 1
Tooth brushing was carried out by 0 professional panelists and evaluated according to the following criteria to obtain an average score. 3: The stress of kneading at the time of brushing is small (kneading is soft), and the dentifrice component sufficiently penetrates into narrow interdental parts and narrow gaps between teeth and gums. 2: The stress of kneading during brushing is a little large (kneading is a little hard), and the toothpaste component enters the narrow interdental part or the gap between the teeth and gums to some extent. 1: The stress of kneading during brushing is large (kneading is hard),
Toothpaste does not enter into narrow interdental spaces or gaps between teeth and gums. (4) Dispersibility: 1 g of sample toothpaste was taken in a test tube,
3 ml of the following artificial saliva was added and shaken 15 times. After that, the dispersion was recovered, the dry weight was measured, and the dispersion rate was calculated according to the following formula. Dispersion rate of toothpaste component (%) = (dispersed toothbrush weight / total dispersed weight) × 100 * Artificial saliva: 50 mM KCl + 1 mM KH ₂ PO ₄ +
1 mM CaCl ₂ +0.1 mM MgCl ₂ , pH =
7.0

[Examples 1 to 5] Toothpaste compositions of the present invention shown in Table 1 were prepared according to a conventional method.

[Table 1] 1) Tokusil GU-N 2) Rheozic 250H

Table 2 shows the evaluation results of Examples 1 to 5 and commercial toothpaste (11 products). Viscosity curve σ showing rheological properties
^1/2 = k ₀ + k ₁ γ ^1/2 , (k ₀ ) ² is 80 Pa or more 4
The toothpaste composition of the present invention having 00 Pa or less and (k ₁ ) ² of 10 Pa · s or less has good moldability on the toothbrush, easy penetration into the gap of the kneading, and dispersibility. It was

[0029]

[Table 2] 3) SKB Co., Ltd .: SmithKline Beecham Pharmaceutical Co., Ltd.

   ─────────────────────────────────────────────────── ─── Continued front page    (72) Inventor Yasuhiko Ide             1-3-7 Honjo, Sumida-ku, Tokyo Rio             Within the corporation (72) Inventor Takashi Yamamoto             1-3-7 Honjo, Sumida-ku, Tokyo Rio             Within the corporation F-term (reference) 4C083 AB172 AB472 AC112 AC622                       AC862 AD092 AD352 CC41                       DD22 EE01 EE07

Claims (2)

[Claims] 1. The following viscosity curve σ ^1/2 = k ₀ + k ₁ γ ^1/2 (where σ is shear stress, γ is shear rate, k ₀ and k ₁ are constants, and (k ₀ ) ² is (Yield stress, (k ₁ ) ² corresponds to plastic viscosity, respectively.), (K ₀ ) ² is 80 Pa or more and 400 Pa or less, and (k ₁ ) ² is 10 Pa · s or less. Toothpaste composition. 2. The toothpaste composition according to claim 1, which contains an anti-inflammatory agent.