JP2003012511A - Aerosol composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an aerosol composition capable of stably keeping urea in such an amount that the urea exhibits a desirable effect. SOLUTION: This aerosol composition comprises a propellant and a stock solution which contains 2-35 wt.% of the urea and 30-90 wt.% of water, wherein the propellant and the stock solution are together mixed so as to have a mixed volume ratio of the propellant to the stock solution of 10:90 to 75:25 in a liquid state.

Description

Detailed Description of the Invention

[0001]

TECHNICAL FIELD The present invention relates to an aerosol composition containing a stock solution containing urea as an essential component and a propellant. More specifically, the present invention, by holding urea in a stable state, effectively exerts a desired effect such as a moisturizing effect of urea, a keratin softening effect or an antipruritic effect,
Moreover, the present invention relates to an aerosol composition in which the generation of malodor caused by the decomposition of urea is significantly suppressed.

[0002]

2. Description of the Related Art An aerosol composition is mainly composed of an aqueous stock solution and a propellant, and a liquefied gas or a compressed gas is usually used as the propellant. Since such a propellant is a component that exerts an effect of giving a cooling sensation to the user by removing heat of vaporization from the skin surface when applied to the skin, it is indispensable for an aerosol composition having a cooling effect. It is an ingredient.

By the way, conventionally, an external preparation containing urea has been known as an external preparation having a moisturizing action, a keratin softening action or an antipruritic action.

[0004] Urea has an effect of increasing the water retention of the keratin, improving the decrease in the water retention of the stratum corneum in keratoderma sicca, dissolving and exfoliating the keratin, and enhancing skin permeability. It is known to have various actions such as a bactericidal action, a wound healing action, a cell activation action, and an antipruritic action against pruritus caused by drying. In order to obtain such a desired effect, it is necessary to mix urea in the preparation at a certain concentration or more, and it is general that urea is dissolved and retained in the preparation using water as a carrier due to its water solubility.

On the other hand, however, urea is known to be unstable in an aqueous solution and decompose into ammonia and carbon dioxide by hydrolysis. And this decomposition is accelerated by heat. Such decomposition not only lowers the drug efficacy due to urea, but also leads to deterioration of the formulation due to pH fluctuations and reduction in commercial value due to coloration or generation of ammonia odor, and therefore must be resolved in the development of urea-containing formulations. This is an important issue. Especially in the case of aerosols,
From the usage form of spraying, a slight amount of ammonia generated by decomposition of urea causes an offensive odor to significantly reduce the commercial value, and therefore, there is great significance in solving the above problems.

[0006]

SUMMARY OF THE INVENTION It is an object of the present invention to solve the above problems of urea-containing external preparations, particularly aerosol compositions, which are associated with the instability of urea in the presence of water. In particular, the present invention aims to provide an aerosol composition that stably holds an amount of urea that exerts the desired effect. More specifically, it is an object of the present invention to provide an aerosol composition in which urea is stably retained in the presence of water, thereby significantly suppressing the generation of malodor associated with the decomposition of urea. .

Further, the present invention aims to provide a method for stably holding urea in an aerosol composition containing urea as an essential component together with water, and a method for preventing generation of a bad odor due to decomposition of urea. It is also something to do.

[0008]

Means for Solving the Problems As a result of intensive studies to solve the above problems, the present inventors have found that in an aerosol composition comprising a propellant and a stock solution containing water and urea as essential components, 2 urea in 100% by weight stock solution
To 30% by weight and 30 to 90% by weight of water were prepared to prepare a stock solution, and the stock solution was added to a propellant.
By blending so as to have a ratio of 25:75 to 90:10 (liquid state, volume ratio), (i) stable retention of urea in the presence of water, (ii) decomposition of urea It was found that the problem of bad odor does not occur, and (iii) the effective effect of urea that is expected can be sufficiently exhibited by containing a stable amount of urea in an effective amount. Then, it was confirmed that such an aerosol composition is useful as a content component of an aerosol agent having a moisturizing action, a keratin softening action or an antipruritic action. The present invention was developed based on such knowledge.

That is, the present invention is an aerosol composition as follows: (1) A propellant, 2 to 35% by weight of urea and 30 to 30% of water.
An aerosol composition comprising an undiluted solution containing 90% by weight, wherein the mixing volume ratio of the propellant and the undiluted solution is 10:90 to 75:25 in the liquid state. (2) The mixing volume ratio of the propellant and the stock solution is 10 in the liquid state:
90 to 50:50, The aerosol composition according to (1). (3) The proportion of urea contained in 100% by weight of the stock solution is 5 to 5.
The aerosol composition according to (1) or (2), which is 30% by weight. (4) The aerosol composition according to any one of (1) to (3), wherein the propellant is at least one selected from dimethyl ether and liquefied petroleum gas. (5) The aerosol composition according to any one of (1) to (4), which further contains a lower alcohol in a proportion of 0.1 to 50% by weight in the stock solution. (6) The aerosol composition according to (5), wherein the undiluted solution further contains a polyhydric alcohol in a proportion of 0.1 to 30% by weight. (7) At least one selected from the group consisting of an antipruritic component, an antiphlogistic analgesic component, an anti-inflammatory component, a local anesthetic component, an antihistamine component, a steroid component, an antibacterial component, a moisturizing component, a vitamin component and an animal or plant extract in the stock solution. The aerosol composition according to any one of (1) to (6), which is

Further, the present invention is an aerosol agent containing the above aerosol composition as a content component. The aerosol is particularly useful as an external preparation (cosmetic, pharmaceutical, quasi drug) having a moisturizing effect, keratin softening effect or antipruritic effect. Therefore, the present invention can be restated as a moisturizing preparation in the form of an aerosol, a keratin softening preparation in the form of an aerosol, and an antipruritic preparation in the form of an aerosol.

The present invention also relates to a method for stably holding urea in an aerosol composition containing urea as an essential component together with water. In this method, a propellant and a stock solution containing urea in an amount of 2 to 35% by weight and water in an amount of 30 to 90% by weight are mixed in a liquid state at a ratio of 10:90 to 75:25 (volume ratio). It can be realized by preparing an aerosol composition as described above.

Further, the present invention relates to a method for preventing the generation of a bad odor due to the decomposition of urea in an aerosol composition containing urea as an essential component together with water. The method comprises 2 to 35% by weight of propellant, urea and 30 to 30% of water.
90% by weight of the stock solution containing 1% in the liquid state
It can be realized by preparing an aerosol composition obtained by mixing at a ratio of 0:90 to 75:25 (volume ratio).

[0013]

BEST MODE FOR CARRYING OUT THE INVENTION The aerosol composition of the present invention comprises a stock solution containing urea and water as essential components, and a propellant.

As described above, urea is added to the preparation at a ratio of a certain concentration or more to increase the water retention of the keratin and reduce the water retention of the stratum corneum in keratosis sicca. It is known that it has various actions such as improving action and dissolving and exfoliating keratin, as well as skin permeability enhancing action, bactericidal action, wound healing action, cell activation action, and further itching action of pruritus due to dryness. Has been. Therefore, in the present invention, in order to effectively bring out the effects of these ureas, it is preferable to add urea in an amount of 2% by weight or more to 100% by weight of the stock solution (chemical solution) to be added to the aerosol composition. In the present invention, by blending 2% by weight or more of urea in the undiluted solution, it is possible to prepare an aerosol composition having a moisturizing effect, an antipruritic effect and a keratin softening effect, and particularly an aerosol composition having an excellent moisturizing effect. . By blending 5% by weight or more of urea, an aerosol composition having a particularly excellent antipruritic effect can be prepared. Further, by blending 10% by weight or more of urea, an aerosol composition having an excellent keratin softening effect can be prepared.

The upper limit of urea to be added to the stock solution is the proportion of water to be added to the stock solution, and the combination with the stock solution, taking into consideration the stability of urea in the aerosol composition, and in particular, the prevention of generation of a bad odor due to decomposition of urea. Can be specified based on the relationship with the blending ratio of the propellant used. In the present invention, the upper limit of urea to be added to 100% by weight of the stock solution (chemical solution) is 35% by weight, preferably 30% by weight. That is, in the present invention, urea is used as the stock solution 10
By blending in an amount of 2 to 35% by weight, preferably 5 to 30% by weight in 0% by weight, the desired effect inherent to urea can be exhibited, and the aerosol composition is excellent in its stability. Can be prepared.

The proportion of water to be added to the stock solution is such that the solubility and stability of urea and, above all, the prevention of a bad odor due to decomposition of urea can be taken into consideration. It can be specified from the relationship with the blending ratio of the propellant used in combination with. The proportion of water in the stock solution 100% by weight is usually 30 to 90% by weight, preferably 30 to 75% by weight, more preferably 30 to 60% by weight.
A range of weight% can be mentioned.

The undiluted solution used in the aerosol composition of the present invention may contain at least the above urea and water as essential components, and may contain other components as long as the effects of the present invention are not impaired. Is not limited in any way.

Examples of such other components include lower alcohols. Here, examples of the lower alcohol include linear or branched alcohols having 1 to 6 carbon atoms such as ethanol, propanol, isopropanol, butanol and the like. Among them, ethanol or isopropanol is preferable from the viewpoint of formulation stability of the components. These lower alcohols may be used alone or in any combination of two or more.

Lower alcohols are useful in enhancing the stability of urea or other ingredients to stock solutions or aerosol compositions. For example, when crotamiton is added as another component, the solubility can be increased by a lower alcohol to make a stable formulation. Further, when an aerosol composition is applied to the skin by blending a lower alcohol, heat of vaporization gives the skin a cooling sensation and a refreshing sensation. Further, the lower alcohol is effective in increasing the compatibility between the water in the stock solution and the propellant and homogenizing the aerosol composition.

When a lower alcohol is blended for the purpose of obtaining such effects, 0.1% by weight or more, preferably 5% by weight or more, and more preferably 10% by weight in 100% by weight of the stock solution.
It is preferably used in a proportion of not less than wt%. It should be noted that the lower alcohol blending has a cooling effect by dissipating the heat of vaporization, but at the same time, tends to deprive sebum and cause skin dryness. 50% by weight, preferably 40% by weight
It is preferable to mix with the upper limit of.

As another component, a polyhydric alcohol can be mentioned. Specific examples of the polyhydric alcohol include propylene glycol, 1,3-butylene glycol, glycerin, diethylene glycol, triethylene glycol, dipropylene glycol, hexylene glycol, polyethylene glycol and ethoxydiglycol. These polyhydric alcohols may be used alone or in any combination of two or more. From the viewpoint of safety and moisturizing effect, preferred are propylene glycol, 1,3-butylene glycol, dipropylene glycol, polyethylene glycol, ethoxydiglycol and glycerin.

Since the polyhydric alcohol is effective in alleviating the cooling sensation caused by the dissipation of the heat of vaporization and protecting the skin from the dryness caused by degreasing, it is used in combination with the above lower alcohol. Is preferred.

When blending a polyhydric alcohol, the stock solution 1
0.1 to 30% by weight in 00% by weight, preferably 0.1 to
It can be used in a proportion of 20% by weight, more preferably 3 to 10% by weight.

The stock solution used in the present invention may also contain an active ingredient other than urea.

As such an active ingredient, various active ingredients which can be usually added to an external preparation can be used. A component having a moisturizing effect, antipruritic effect, keratin softening effect, or an effect of enhancing these effects is desirable. Specifically, antipruritic components, antiphlogistic and analgesic components, anti-inflammatory components, local anesthetic components, antihistamine components, steroid components, antibacterial components, moisturizing components, vitamin components, local paralytic components, and animal and plant extracts can be exemplified. . In addition, these 1 type or 2 types or more can be used in combination.

Here, as the antipruritic ingredient, crotamiton,
Ictamol, moctamol, thymol acid, etc. are illustrated. Preferred is crotamiton. Examples of the anti-inflammatory and analgesic components include indomethacin, salicylic acid and derivatives thereof (methyl salicylate, salicylic acid monoglycol ester, etc.), ketoprofen, flurbiprofen, piroxicam, diclofenac, ibuprofen, mefenamic acid and the like. Salicylic acid or a derivative thereof is preferable. As the anti-inflammatory component, guaiazulene or a salt thereof, allantoin, glycyrrhetinic acid or a derivative thereof (such as a nitrate ester or acetic acid ester of glycyrrhetinic acid), glycyrrhizic acid or a derivative thereof (a nitrate ester or acetate ester of glycyrrhizinic acid, stearyl glycyrrhizinate, etc.) Is exemplified. Preferred are allantoin, glycyrrhetinic acid or a derivative thereof, and glycyrrhizic acid or a derivative thereof. Examples of the local anesthetic component include lidocaine, dibucaine, amino acid ethyl benzoate and the like. Lidocaine or dibucaine is preferred.
Examples of the antihistamine component include chlorpheniramine, diphenhydramine, isothibenzyl and derivatives thereof. Examples of the steroid component include hydrocortisone, dexamethasone, prednisolone, and their derivatives. Examples of the antibacterial component include undecylenic acid, pentachlorophenol, clotrimazole, tolnaftate, trichomycin, miconazole, potassium iodide, chlorhexidine, acrinol, benzalkonium, penicillin, tetracycline, fradiomycin, kanamycin or derivatives thereof. .

As the moisturizing component, polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol and dipropylene glycol; squalane, liquid paraffin, avocado oil, soybean oil, castor oil, rice germ oil, etc. Examples include liquid oils; amino acids such as glycine, alanine and aspartic acid; sugars such as sorbitol, maltitol, trehalose and glucose; organic acids such as lactic acid and pyrrolidonecarboxylic acid. As the vitamin component, those having an effect of recovering NMF component or skin damage and suppressing inflammation are preferable. Vitamin E and its derivatives such as tocopherol, vitamin B6 and its derivatives such as pyridoxine, vitamin A such as retinol and the like. Examples thereof include derivatives thereof, pantothenic acid and derivatives thereof, vitamin C such as ascorbic acid and derivatives thereof, biotin and the like. As a local paralysis component,
Examples include capsicum, mustard, cantharis, cantharidin, capsaicin and the like. In addition, as the animal and plant extract, those which are said to have a moisturizing effect, an anti-inflammatory effect, or an effect of improving skin roughness are preferred, and specifically, keratins, collagens, hyaluronic acid, chondroitin sulfate, aloe. Extract, hamamelis extract, rosemary extract, horse chestnut extract, cucumber extract, quince extract, royal jelly extract, seaweed extract, tea extract, carrot extract, peach extract, peach leaf extract , Licorice extract, sardine extract, eucalyptus extract, peppermint extract, lavender extract, evening primrose extract,
Examples thereof include chamomile extract, Japanese citrus extract, and fermented rice extract.

The above-mentioned specific components include pharmaceutically acceptable salts thereof, particularly pharmaceutically acceptable salts usually used in the art for the purpose of external use.

The stock solution used in the present invention usually has a pH of 2 to 10.
It should have the liquid property of
Also, from the viewpoint of good feeling on skin use, pH is preferable.
It is preferably 3 to 9, more preferably weakly acidic to neutral with a pH of 5 to 8.

If the viscosity of the undiluted solution is less than 0.5 cSt, the adhesion of the aerosol composition to the skin tends to be low, and if the viscosity exceeds 20 cSt, the skin tends to be sticky. Therefore, from the viewpoint of obtaining a good feeling in use, it is desirable to adjust the viscosity of the stock solution to a range of usually 1 cSt to 20 cSt. In addition, the viscosity here is a BL viscometer (BL
It means the kinematic viscosity measured by using an adapter, rotation speed 30 rpm, measuring temperature 29 ° C., density measurement: using pycnometer). Preferably 1 cSt to 10 cSt, more preferably 1 cSt
~ 5 cSt.

The aerosol composition of the present invention can be prepared by blending the above-mentioned stock solution with a propellant.

The propellant used in the present invention may be any propellant having compatibility with the above-mentioned stock solution, and specifically, liquefied petroleum gas (eg, ethane, propane, ethylene, isobutane, normal butane, propylene). Such as a gas that easily liquefies, a mixed gas thereof [eg, a mixed gas of isobutane and propane, a mixed gas of propane and butane], an ether propellant (such as dimethyl ether),
Examples thereof include fluorocarbon (for example, fluorocarbon, chlorofluorocarbon, bromochlorofluorocarbon), compressed gas (carbon dioxide, air, mixed gas names thereof, etc.), or CFC gas (monochlorodifluoroethane, tetrafluoroethane, etc.). In addition, these propellants may be used alone or in any combination of two or more. Preferred is dimethyl ether, or liquefied petroleum gas, and particularly preferred is dimethyl ether, which has excellent usability including cooling feeling.
Alternatively, it is a mixed gas of dimethyl ether and liquefied petroleum gas.

The mixing ratio of the undiluted solution and the propellant in the aerosol composition of the present invention is based on the volume of the undiluted solution:
It is preferable that the propellant is 25:75 to 90:10 (volume ratio). More preferably stock solution: propellant = 50: 5
It is 0 to 90:10. If the proportion of the undiluted solution blended in the aerosol composition is less than 25% by volume, the stability of urea tends not to be sufficiently maintained, while if the proportion of the propellant is less than 25% by volume, it is used as an aerosol agent. In such a case, all of the stock solution containing the active ingredient cannot be used to the end, and there is a tendency that the solution remains in the container.

In the aerosol composition of the present invention, if necessary, a cooling agent, a solubilizing agent, a surfactant, a chelating agent,
A pH adjuster, a preservative, an antioxidant, a fragrance, or the like may be added.

Among them, the cooling agent has the effect of increasing the cooling sensation and not only excels in the feeling of use, but also has the effect of immediately suppressing the itch, which is useful for the preparation of an aerosol for the purpose of antipruritus. Is. As the cooling agent, l-menthol and 3-L-methoxypropane-1,2-diol are preferable. Particularly, 1-menthol or an essential oil containing 1-menthol is preferable.

As the solubilizing agent, diisopropyl adipate, isopropyl myristate, 1,3-butylene glycol, propylene glycol, polyethylene glycol, glycerin, lactic acid, sodium hydroxide and the like; as the surfactant, polyoxyethylene Sorbitan fatty acid ester, sorbitan fatty acid ester, polyoxyethylene hydrogenated castor oil, polyoxyethylene polyoxypropylene alkyl ether, polyoxyethylene cetyl ether, glyceryl monostearate, etc .; chelating agents edetic acids, hydroxyethanediphosphonic acids, phytin Acids and the like; preservatives such as paraben, benzoate, isopropylmethylphenol and the like; antioxidants such as tocopherol acetate, dibutylhydroxytoluene and butylhydroxy Toluene and the like.

The aerosol composition of the present invention is used in the form of an aerosol by filling a stock solution and a propellant into an aerosol container such as steel or aluminum by a known method. As long as the object of the present invention is not impaired, not only the composition of the undiluted solution, but also the injection amount or spraying / injection state of the content, the pressure in the aerosol container, the injection hole diameter in the valve of the aerosol container, the diameter of the stem passage, etc. are appropriately set. By setting, it can be appropriately selected and used according to the purpose.

The aerosol composition of the present invention can be applied to makeup cosmetics such as foundations, lipsticks, and nail enamel, and basic cosmetics; cleansing agents such as face cleansing agents, cleansing agents, and body wash agents; armpit deodorants, athlete's foot remedies. In the field of cosmetics, topical drugs or quasi-drugs such as agents, antipruritic agents, wound healing agents, anti-inflammatory analgesics, acne treatment agents, antiseptic agents, whitening agents, UV protectants, moisturizers, keratin softeners, etc. It can be used as an aerosol for various external applications to which it belongs. The present invention is preferably prepared as an aerosol agent having a moisturizing effect, a keratin softening effect or an antipruritic effect which is the effect of urea. Specific examples include cosmetics or detergents in the form of an aerosol having a moisturizing effect, keratin softening effect or antipruritic effect, and an antipruritic preparation, a moisturizing preparation or a keratin softening preparation in the form of an aerosol.

[0039]

EXAMPLES The present invention will be described below in more detail based on Examples and Test Examples, but the present invention is not limited to these Examples and the like. In each prescription below,%
Unless otherwise specified, it means% by weight (W / W).

Example 1 Moisturizing preparation <stock solution> Urea 10.0 (%) Vitamin E 5.0 1,3-butylene glycol 5.0 Ethanol 40.0 Purified water 40.0 Total 100.0% <Propellant > Dimethyl ether 100.0% <stock solution>: <propellant> = 70:30 (volume ratio)

Example 2 Cosmetic <Undiluted solution> Urea 5.0 (%) Glycerin 5.0 Lactic acid 1.5 Ethanol 30.0 Fragrance 0.1 Purified water 58.4 Total 100.0% <Propellant> Liquefaction Petroleum gas 100.0% <stock solution: propellant> = 60:40 (volume ratio).

Example 3 Skin Protective Foam <Undiluted solution> Urea 7.0 (%) Hydroxyethyl cellulose 0.3 Xanthan gum 0.1 Propylene glycol 5.0 Squalane 1.0 Cetanol 1.0 Glyceryl monostearate 0.2 Polyoxy Ethylene cetyl ether 0.3 KSG16 (Shin-Etsu Chemical) 0.5 Laurylmethyl taurine Na 3.0 Ethanol 1.0 Perfume 0.2 Purified water 80.4 Total 100.0% <Propellant> Dimethyl ether 50.0 Liquefied petroleum Gas 50.0 100.0% <stock solution: propellant> = 55:45 (volume ratio).

Example 4 Shaving foam <stock solution> Urea 15.0 (%) Stearic acid polyglyceride 1.0 Dipropylene glycol 20.0 Stearic acid 0.5 Cetanol 2.0 Paraffin 0.5 Polyoxyethylene hydrogenated castor oil 1.0 Silicone KF-96A (20cs) (Shin-Etsu Chemical) 1.0 Hydroxyethyl cellulose 0.4 Sodium hydroxide (adjusted to pH 7) 0-0.1 Purified water 58.5-58.6 Total 100.0% <Propellant> Liquefied petroleum gas 100.0% <Undiluted solution: propellant> = 95: 5 (volume ratio).

Example 5 Antipruritic preparation <stock solution> Urea 8.0 (%) Chlorpheniramine maleate 1.0 Crotamiton 5.0 Prednisolone 0.1 Allantoin 0.1 Isopropylmethylphenol 0.1 l-Menthol 0.2 Ethanol 40.0 Purified water 45.5 Total 100.0% <propellant> Liquefied petroleum gas: dimethyl ether = 50:50 <stock solution: propellant> = 80:20 (volume ratio).

Example 6 Preparation for athlete's foot <stock solution> Urea 5.0 (%) Sulconazole nitrate 0.5 Dibucaine hydrochloride 0.1 Ethanol 3.0 Purified water 91.4 Total 100.0% <Propellant> Dimethyl ether: Liquefied petroleum gas = 90:10 <stock solution: propellant> = 50:50 (volume ratio).

Example 7 Keratin softening preparation <stock solution> urea 25.0 (%) polyoxyethylene sorbitan fatty acid ester 1.0 glycerin 3.0 jojoba oil 5.0 purified water 66.0 total 100.0%. <Propellant> dimethyl ether: liquefied petroleum gas = 40:60 <stock solution: propellant> = 80:15 (volume ratio).

Test Example 1 Stability of Urea in Aerosol Composition According to the formulation shown in Table 1, a stock solution containing urea and water at a predetermined ratio was prepared, and then this stock solution and a propellant were mixed at a predetermined ratio. Then, it was filled in an aerosol can and stored in a constant temperature bath at 40 ° C. for 1 month to confirm the stability of urea (decomposition resistance, dissolution stability) (Examples 8 to 16 and Comparative Examples 1 to 1).
4).

(1) Stability (decomposition resistance) The stability (decomposition resistance) of aerosol compositions (Examples 8 to 16 and Comparative Examples 1 to 4) is based on the fact that urea decomposes to generate ammonia. Then, the presence or absence of ammonia odor in the sprayed product when sprayed for 1.5 seconds was evaluated.

The strength of ammonia odor was evaluated according to the following 5 grades. − Do not feel the smell of ammonia + Feel a slight amount ++ Significantly feel ++++ Feel strongly ++++ Feel strongly ++++++ Feel uncomfortably strong.

(2) Dissolution stability The dissolution stability of the aerosol compositions (Examples 8 to 16 and Comparative Examples 1 to 4) was determined by observing the state of the contents of the aerosol can (aerosol composition) with a microscope and causing precipitation. It was evaluated by examining the presence or absence of a substance or crystal precipitation. Further, after spraying, the aerosol can was left at room temperature for 1 day, and then the presence or absence of crystal precipitation at the injection port of the can was visually observed. The presence / absence of crystal precipitation was evaluated as "+" for existence and "-" for absence. The results are also shown in Table 1.

[0051]

[Table 1]

As can be seen from the results in Table 1, all of the aerosol compositions having the formulations of the present invention have excellent thermal stability (decomposition resistance, dissolution stability), and the results show that even after long-term storage, urea composition Have been shown to be stably held.

[0053]

The aerosol composition of the present invention is characterized by being prepared by blending a stock solution containing urea and water in a specific ratio with a propellant in a specific ratio. According to the aerosol composition of the present invention prepared by such a formulation, urea is stably retained for a long period of time even in the coexistence of water, and therefore, the desired effect of urea (moisturizing effect, keratin softening and hardening) is obtained according to the blended amount. It is suitable as a content composition of an aerosol agent (spray agent) to be used by spray discharge because it can exert an antipruritic effect) and does not generate a bad odor due to decomposition of urea. Further, the aerosol composition of the present invention,
Since urea is stably retained without precipitation or precipitation even after long-term storage, it does not cause inconveniences such as clogging of the discharge port of an aerosol container, and is useful as a content composition of an aerosol agent (spray agent). be able to.

─────────────────────────────────────────────────── ─── Continued Front Page (51) Int.Cl. ⁷ Identification Code FI Theme Coat (Reference) A61K 7/00 A61K 7/00 S 9/12 9/12 45/00 45/00 47/06 47/06 47/10 47/10 A61P 17/00 A61P 17/00 17/04 17/04 17/16 17/16 F term (reference) 4C076 AA24 BB31 CC04 CC18 CC20 DD34 DD37 DD38 DD39 FF57 FF70 4C083 AB032 AC011 AC012 AC022 AC072 AC101 AC102 AC111 AC122 AC152 AC171 AC172 AC182 AC242 AC302 AC392 AC432 AC681 AC682 AC792 AD042 AD112 AD282 AD352 AD662 CC21 DD08 EE10 EE12 4C084 AA02 AA03 AA16 AA27 CA13 CA17 CA59 MA02 MA13 MA63 NA05 ZA082 ZA212 ZA902 ZA912 ZB112 ZC132 4C206 AA01 HA27 MA01 MA02 MA05 MA83 NA05 ZA89 ZA91

Claims (7)

[Claims] 1. An aerosol composition comprising a propellant and a stock solution containing urea in an amount of 2 to 35% by weight and water in an amount of 30 to 90% by weight, wherein a mixing volume ratio of the propellant to the stock solution is 1. An aerosol composition, which is 10:90 to 75:25 in a liquid state. 2. The aerosol composition according to claim 1, wherein the mixing volume ratio of the propellant and the stock solution is 10:90 to 50:50 in the liquid state. 3. The aerosol composition according to claim 1, wherein the proportion of urea contained in 100% by weight of the stock solution is 5 to 30% by weight. 4. The propellant is at least one selected from dimethyl ether and liquefied petroleum gas.
The aerosol composition according to any one of 1 to 3. 5. A lower alcohol is further added to the stock solution in an amount of 0.1 to 1.
The aerosol composition according to any one of claims 1 to 4, which is contained in a proportion of 50% by weight. 6. A polyhydric alcohol is further added to the stock solution in an amount of 0.1 to 10.
The aerosol composition according to claim 5, which is contained in a proportion of 30% by weight. 7. An antipruritic component, an anti-inflammatory analgesic component in the stock solution,
The aerosol according to any one of claims 1 to 6, which is at least one selected from the group consisting of an anti-inflammatory component, a local anesthetic component, an antihistamine component, a steroid component, an antibacterial component, a moisturizing component, a vitamin component and an animal or plant extract. Composition.