JP2002338487A - Drug for external use - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a drug for external use effective for suppressing itchiness, curing roughened skin and improving the cleanliness, smoothness, moistness and softness of the skin. SOLUTION: The drug for external use contains mugwort extract, ethanol and sodium bicarbonate.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation.

[0002]

2. Description of the Related Art
Various drugs such as corticosteroids have been developed to stop itching of human skin. However, some of these drugs have strong side effects, require careful use, and are difficult to use for a long time. On the other hand, those with weak side effects have a low effect on itch. Artemisia extract has few side effects,
It is known that it has an effect of suppressing itch, but it is desired that the effect can be improved more than the extract alone. Extracts from mugwort have been used in cosmetics and external medicines, and their effects include antibacterial,
Deodorant, antioxidant, amylase inhibition, improvement of atopic dermatitis, promotion of blood circulation, improvement of skin pruritus, testosterone-5
Inhibition of α-reductase, inhibition of glycosyltransferase, inhibition of collagenase, and the like are known.

[0003]

SUMMARY OF THE INVENTION The present invention relates to an external preparation containing a mugwort extract, ethanol and sodium bicarbonate. As used herein, the term “external preparation” includes external preparations as pharmaceuticals or quasi-drugs, and cosmetics. The mugwort used in the present invention is a plant belonging to the genus Artemisia, including what is commonly called mugwort, such as mugwort, sagebrush, sagebrush, sagebrush, sagebrush, etc., and can be used alone or in combination. .

In order to obtain the extract of mugwort used in the present invention, any site such as mugwort flowers, stems, leaves and roots, or whole plants may be used. And either raw or dried ones can be used. In the present invention, these mugwort extracts are used. For the extraction, water or a polar organic solvent is used. However, considering the subsequent treatment, it is preferable to use water or ethanol. In the case where water is used, the treatment can be performed at room temperature, but is preferably performed by heating. The amount of water used is, for example, 10 L or less, preferably 7 L per 100 g of dried mugwort.
Hereinafter, 1-5 L is more preferably used. The heating is
It is preferable to carry out at around the boiling point of the solvent. The heating time may be long, for example, 15 minutes or more, preferably 20-60
Minutes. After the solvent treatment, the mixture is cooled to room temperature, and the mugwort body is removed by filtration, decantation, or the like to obtain an extract. The obtained extract can be treated, for example, concentrated, and the obtained concentrate can be used.

In the present invention, ethanol and sodium hydrogen carbonate are added to the obtained aqueous extract of mugwort. Since sodium hydrogen carbonate is insoluble in ethanol, care must be taken when adding it. The amount of ethanol used is 0.5 to 2 times, preferably 0.8 to 1.5 times the volume of the aqueous extract of mugwort. The amount of sodium bicarbonate used is 0.0% by weight with respect to the aqueous extract of mugwort.
The concentration is from 5 times to the saturation concentration, preferably from 0.06 times to the saturation concentration. In the present invention, the object can be achieved by using both ethanol and sodium hydrogen carbonate in combination.

[0006] To further achieve the effects of the present invention, a humectant may be added. The humectants used include camellia oil, olive oil and the like. The amount used may be a small amount, for example, 0.1-5 mL, preferably 1-3 mL.

[0007] The external preparation of the present invention can be used in the form of a liquid, for example, a lotion, and in the form of an emulsion, cream, gel, ointment, powder or the like according to a conventional method. Further, the external preparation of the present invention contains, in addition to the above-mentioned active ingredients, if necessary, additives used in conventional external preparations such as fragrances, coloring agents, and preservatives as long as the effects of the present invention are not impaired. Fees and the like.

[0008] The external preparation of the present invention is effective for stopping itching. Further, it is effective as a cosmetic for improving skin cleanliness, rough skin, smoothness, moisture or softness, and the like. The amount of the external preparation of the present invention, when used for anti-itch, is 1 day per day depending on the degree of itching.
Apply one to several times. In addition, when used as cosmetics, it follows the manner in which ordinary cosmetics are used.

The external preparation of the present invention has no toxicity due to its constitution.

[0010]

EXAMPLE 1 The leaves and stems of a mugwort were collected, washed with water, shaded for 3-4 days, and dried. 2.5 kg of the dried mugwort obtained was added to 50 parts of water.
Boiled in L for about 30 minutes, then cooled and filtered. 45 L of the obtained filtrate was used as a stock solution. Separately, 10 g of sodium bicarbonate was added to 100 mL of water and heated to 40 ° C. to form a solution. Stock solution 50 mL, aqueous sodium hydrogen carbonate solution 1
00 mL and 50 mL of ethanol were mixed, and 10 drops of camellia oil was added to the mixture. The resulting solution was applied three times a day to the affected area of a patient who complained of itching. If you continue applying for two weeks,
Itching stopped. Before the application of the mixture, the patient used only mugwort extract for one month, but the itch did not stop.

Example 2 1 kg of whole mugwort was placed in 2 L of a 50% aqueous ethanol solution and immersed at room temperature for 3 days. The extract was filtered, and the filtrate was used as a stock solution. Separately, add 10 g of sodium bicarbonate to 100
mL and heated to 40 ° C. to form a solution. Stock solution 50
mL, 100 mL of an aqueous sodium hydrogen carbonate solution and 50 mL of ethanol were mixed, and 10 drops of olive oil were added to the mixture. Apply the resulting solution to the affected area of a patient who complains of itching.
It was applied three times a day. After 3 weeks of application, itching stopped. Before the application of the mixture, the patient used only mugwort extract for 2 months, but the itch did not stop.

Example 3 A solution was obtained by adding 7 g of sodium hydrogencarbonate to 100 mL of water. 50 m of the stock solution obtained in Example 1 was added to the obtained solution.
L and 50 mL of ethanol were added and mixed, and 5 drops of camellia oil was added to the mixture. When the obtained solution was used, the same effect as in Example 1 was obtained.

Example 3 A lotion was prepared using a mixture of the water extract of mugwort obtained in the manner of Example 1, sodium bicarbonate and ethanol. The components were as follows: 94.75% by weight of the mixture, 4% by weight of glycerin, 1% by weight of polyoxyethylene hydrogenated castor oil, 0.1% by weight of citric acid,
0.05% by weight of methyl paraben, 0.1% by weight of fragrance. The obtained cosmetic solution was more effective than the mugwort extract alone in preventing and improving skin roughness.

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Claims (2)

[Claims] An external preparation containing a mugwort extract, ethanol and sodium hydrogen carbonate. 2. The external preparation according to claim 1, further comprising a humectant.