JP2002315721A - Stereoscopic system for enucleation of cancer tissue - Google Patents
Stereoscopic system for enucleation of cancer tissueInfo
- Publication number
- JP2002315721A JP2002315721A JP2001123044A JP2001123044A JP2002315721A JP 2002315721 A JP2002315721 A JP 2002315721A JP 2001123044 A JP2001123044 A JP 2001123044A JP 2001123044 A JP2001123044 A JP 2001123044A JP 2002315721 A JP2002315721 A JP 2002315721A
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- Prior art keywords
- image
- cancer tissue
- stereoscopic
- camera
- microscope
- Prior art date
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Links
- 201000011510 cancer Diseases 0.000 title claims abstract description 38
- 206010028980 Neoplasm Diseases 0.000 title claims abstract description 37
- 230000007159 enucleation Effects 0.000 title abstract 2
- 239000007850 fluorescent dye Substances 0.000 claims abstract description 9
- 238000001356 surgical procedure Methods 0.000 claims description 13
- 230000002194 synthesizing effect Effects 0.000 claims description 7
- 238000003384 imaging method Methods 0.000 claims description 5
- 238000002271 resection Methods 0.000 claims description 4
- ZGXJTSGNIOSYLO-UHFFFAOYSA-N 88755TAZ87 Chemical compound NCC(=O)CCC(O)=O ZGXJTSGNIOSYLO-UHFFFAOYSA-N 0.000 abstract description 11
- 238000000034 method Methods 0.000 description 9
- 230000003287 optical effect Effects 0.000 description 8
- 239000004973 liquid crystal related substance Substances 0.000 description 7
- 230000015572 biosynthetic process Effects 0.000 description 3
- 238000003786 synthesis reaction Methods 0.000 description 3
- 238000012757 fluorescence staining Methods 0.000 description 2
- 208000035965 Postoperative Complications Diseases 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 230000004069 differentiation Effects 0.000 description 1
- 230000005284 excitation Effects 0.000 description 1
- 230000009545 invasion Effects 0.000 description 1
- 230000033001 locomotion Effects 0.000 description 1
- 238000010297 mechanical methods and process Methods 0.000 description 1
- 238000004393 prognosis Methods 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
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- Microscoopes, Condenser (AREA)
- Endoscopes (AREA)
Abstract
Description
【0001】[0001]
【発明の属する技術分野】本発明は、癌組織摘出手術用
の立体視システムに関するものである。BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a stereoscopic system for surgical removal of cancer tissue.
【0002】[0002]
【従来の技術】悪性腫瘍などの「癌」は、MRI・CT
などにより、事前の検査で診断できるが、実手術におけ
る顕微鏡又は内視鏡の視野では、癌組織を視覚により明
瞭に区別ができず、手術操作による組織の移動もあるの
で、癌組織の同定が困難である。従って、1回の手術で
癌組織の完全な除去ができず、再手術が必要になる場合
がある。2. Description of the Related Art "Cancer" such as malignant tumors is obtained by MRI / CT.
Although it can be diagnosed by prior examination, etc., in the field of view of a microscope or endoscope in actual surgery, cancer tissue can not be clearly distinguished visually and there is movement of tissue due to surgical operation, so cancer tissue identification Have difficulty. Therefore, cancer tissue cannot be completely removed by one operation, and re-operation may be required.
【0003】そこで、既に発表されている5−ALA
(5-Aminolevulimic Acid)を使った蛍光染色により癌
組織を正確に色で同定して、手術中における癌組織の状
態を逐次正確に把握することが考えられる。[0003] Therefore, 5-ALA which has already been announced
It is conceivable that the cancer tissue is accurately identified by color by fluorescent staining using (5-Aminolevulimic Acid), and the state of the cancer tissue during the operation is sequentially and accurately grasped.
【0004】[0004]
【発明が解決しようとする課題】しかしながら、このよ
うな5−ALAを使った蛍光染色による癌組織の観察
も、通常のテレビモニタで行ったのでは、解像度の低さ
による画像情報の少なさや、映像の色再現性の劣化等に
より、5−ALAの蛍光染色を利用したことによる本来
の色別性が十分に発揮されないため、現在5−ALAの
蛍光染色を利用した癌組織の観察に最適な立体視システ
ムの提案が待たれている。However, observation of cancer tissue by fluorescence staining using 5-ALA as described above has been performed using a normal television monitor, and the image information has been reduced due to the low resolution. Due to deterioration of the color reproducibility of the image, etc., the original color distinction due to the use of 5-ALA fluorescent staining is not sufficiently exhibited. A proposal for a stereoscopic vision system is awaited.
【0005】本発明は、このような実情に鑑みてなされ
たものであり、5−ALAの蛍光染色を利用した色別性
を高めて、癌組織の完全な除去手術を可能にする癌組織
摘出手術用の立体視システムを提供するものである。[0005] The present invention has been made in view of such circumstances, and it is intended to enhance the color differentiation by using 5-ALA fluorescent staining to remove cancer tissue completely. A stereoscopic vision system for surgery is provided.
【0006】[0006]
【課題を解決するための手段】上記目的を達成するため
に、本発明に係る癌組織摘出手術用の立体視システム
は、顕微鏡又は内視鏡と、顕微鏡又は内視鏡からの左右
の像を立体的に撮影する2つのハイビジョンカメラと、
顕微鏡又は内視鏡と同じ視野の中から5−ALAを吸収
した癌組織の蛍光染色を撮影するセンサーカメラと、ハ
イビジョンカメラの片方とセンサーカメラとを切替える
切替手段と、を有する立体撮像系と、センサーカメラの
映像を保持してハイビジョンカメラの映像に合成するセ
ンサー映像合成系と、ハイビジョンカメラの映像、セン
サーカメラの映像、センサーカメラの映像を合成したハ
イビジョンカメラの映像を表示可能な立体映像表示系
と、から構成されるものである。In order to achieve the above object, a stereoscopic system for cancer tissue resection according to the present invention comprises a microscope or an endoscope, and left and right images from the microscope or the endoscope. Two high-definition cameras that shoot three-dimensionally,
A stereoscopic imaging system having a sensor camera that captures fluorescence staining of cancer tissue that has absorbed 5-ALA from the same field of view as a microscope or endoscope, and a switching unit that switches between one of the high-definition cameras and the sensor camera, A sensor image synthesis system that holds the image of the sensor camera and synthesizes it with the image of the high-definition camera, and a stereoscopic image display system that can display the image of the high-definition camera, the image of the sensor camera, and the image of the high-definition camera that combines the image of the sensor camera And
【0007】本発明によれば、5−ALAを使った蛍光
染色による癌組織の同定画像を、顕微鏡又は内視鏡のハ
イビジョンカメラによる実野像に合成して確認するた
め、癌組織の色区別性が高まる。従って、術中における
癌組織を逐次正確に把握できるようになり、正常な組織
を傷つけることなく、1回の手術で過不足なく癌組織だ
けを確実に除去することができる。According to the present invention, an identification image of a cancer tissue by fluorescent staining using 5-ALA is synthesized with a real image by a high-definition camera of a microscope or an endoscope to confirm the image. The nature increases. Therefore, the cancer tissue during the operation can be sequentially and accurately grasped, and it is possible to reliably remove only the cancer tissue by one operation without damaging the normal tissue.
【0008】このように、術中に5−ALAを使った癌
組織の映像を、正確な手術部位のナビゲーション情報と
して合成表示することにより、癌組織を完全に除去でき
ようになるため、手術の正確性・安全性を高めることが
できる。また、患者の身体的ダメージを最小限にでき、
手術予後の改善、術後合併症の抑制効果により、患者が
早期に回復できるため、入院期間が短縮し、結果的に医
療費の抑制効果も期待される。[0008] As described above, by synthesizing and displaying an image of a cancer tissue using 5-ALA during the operation as accurate navigation information of a surgical site, it becomes possible to completely remove the cancer tissue. It can improve sex and safety. It also minimizes physical damage to the patient,
Improving the prognosis of surgery and suppressing postoperative complications can promptly recover patients, shortening the length of hospital stay and consequently reducing medical costs.
【0009】[0009]
【発明の実施の形態】以下、本発明の好適な実施形態を
図面に基づいて説明する。DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of the present invention will be described below with reference to the drawings.
【0010】この実施形態に係る癌組織摘出手術用の立
体視システムは、立体撮像系Aと、センサー映像合成系
Bと、立体映像表示系Cとから構成されている。The stereoscopic vision system for cancer tissue removal surgery according to this embodiment includes a stereoscopic imaging system A, a sensor video synthesis system B, and a stereoscopic video display system C.
【0011】立体撮像系Aは、手術顕微鏡1と、2つの
ハイビジョンカメラ2、3と、センサーカメラ4と、2
つの光学アダプター5、6と、切替器7とから成る。手
術顕微鏡1は、微細で正確な治療を必要とする脳神経外
科等の手術において用いられる双眼顕微鏡である。The stereoscopic imaging system A includes an operating microscope 1, two high-vision cameras 2, 3, a sensor camera 4,
It comprises two optical adapters 5 and 6 and a switch 7. The operation microscope 1 is a binocular microscope used in operations such as neurosurgery that requires fine and accurate treatment.
【0012】2つの光学アダプター5、6は、手術顕微
鏡1の左右に設けられた2つの側視鏡の光路にそれぞれ
設けられている。この2つの光学アダプター5、6を介
して、左目(L)用のハイビジョンカメラ2と、右目
(R)用のハイビジョンカメラ3が取付けられている。
2つのハイビジョンカメラ2、3は、例えば縦横比V:
Hが9:16用のものであり、接続された光学アダプタ
ー5、6からの左目、右目用の映像を、それぞれがV:
H=9:8の2つの像を接合した1つの映像信号として
撮像することができる。The two optical adapters 5 and 6 are respectively provided in the optical paths of two side endoscopes provided on the left and right sides of the operation microscope 1. A high-definition camera 2 for the left eye (L) and a high-definition camera 3 for the right eye (R) are attached via the two optical adapters 5 and 6.
The two high-definition cameras 2 and 3 have, for example, an aspect ratio V:
H is for 9:16, and the left and right eye images from the connected optical adapters 5 and 6 are V:
An image can be taken as one video signal in which two images of H = 9: 8 are joined.
【0013】そして、センサーカメラ4は、右目用の光
学アダプター5に切替器7を介して接続されている。こ
のセンサーカメラ4は、手術顕微鏡1の焦点位置に特定
波長の励起光を照射して、その視野内における5−AL
Aを吸収した癌組織の蛍光映像をフィルターを介して撮
影するものである。このセンサーカメラ4による撮影
は、切替器7内の可動ミラー8の角度を切替えることに
より逐次行われる。The sensor camera 4 is connected to a right-eye optical adapter 5 via a switch 7. The sensor camera 4 irradiates the focal position of the operation microscope 1 with excitation light having a specific wavelength, and emits 5-AL within its field of view.
A fluorescent image of the cancer tissue that has absorbed A is photographed through a filter. The photographing by the sensor camera 4 is sequentially performed by switching the angle of the movable mirror 8 in the switch 7.
【0014】立体映像表示系Cには、R・Lハイビジョ
ンカメラ立体映像合成回路基板を具備したハイビジョン
液晶モニター9が備えられている。このハイビジョン液
晶モニター9で、送られてきた信号に応じた表示を行う
ことにより、横長の表示画面(V:H=9:16)を左
右にほぼ2分割した画面領域に、左右それぞれの視差を
持った映像が形成される。The three-dimensional image display system C is provided with a high-vision liquid crystal monitor 9 having an R / L high-vision camera three-dimensional image synthesizing circuit board. By performing display in accordance with the transmitted signal on the high-definition liquid crystal monitor 9, the parallax of each of the left and right is divided into a screen area obtained by dividing a horizontally long display screen (V: H = 9: 16) into two right and left parts. The held image is formed.
【0015】センサー映像合成系Bにはコンピュータ1
0が備えられ、センサーカメラ4のための蛍光映像画像
処理回路・ソフト、蛍光映像合成回路、逐次制御システ
ムが具備されており、センサーカメラ4からの蛍光映像
を保持して、必要な時にハイビジョンカメラ2、3から
の映像信号に合成できる。また、コンピュータ10で
は、CTやMRIの映像、経過映像、CG映像、超音波
ナビゲーターによる超音波誘導映像等の医療情報11
も、ハイビジョンカメラ2、3からの映像信号に合成で
きるようになっている。A computer 1 is provided in the sensor image synthesizing system B.
0, equipped with a fluorescent image processing circuit / software for the sensor camera 4, a fluorescent image synthesizing circuit, and a sequential control system. The fluorescent image from the sensor camera 4 is held, and a high-definition camera is used when necessary. It can be combined with video signals from two or three. The computer 10 also provides medical information 11 such as CT and MRI images, progress images, CG images, and ultrasonic guidance images by an ultrasonic navigator.
Can be combined with video signals from the high-vision cameras 2 and 3.
【0016】この実施形態に係る癌組織摘出手術用の立
体視システムは、以上のような構成をしているため、ハ
イビジョンカメラ2、3で撮像された立体映像中に、セ
ンサーカメラ4で逐次撮影した映像を立体映像として合
成し、ハイビジョン液晶モニター9上に表示することが
できる。Since the stereoscopic vision system for surgical removal of cancer tissue according to this embodiment has the above configuration, the sensor camera 4 sequentially captures three-dimensional images captured by the high-vision cameras 2 and 3. The synthesized video can be synthesized as a stereoscopic video and displayed on the high-vision liquid crystal monitor 9.
【0017】ハイビジョン液晶モニター9の立体視の方
法には、補助装置を使わない裸眼による方法と、「立体
視ビューア」と称される観察補助装置による方法があ
る。裸眼視による立体視には平行法と交差法があり、平
行法では左目用像を左側に、右目用像を右側に配置し、
逆に交差法では左目用像を右側に、右目用像を左側に配
置するようにする。これを実現する方法としては、光学
アダプター5、6内に設けられているレンズやミラー、
或いはハイビジョンカメラ2、3自体を回転させて行う
機械系の方法と、フレームメモリと映像合成装置などを
使う電子系の方法とがある。The method of stereoscopic viewing of the high-vision liquid crystal monitor 9 includes a method using the naked eye without using an auxiliary device and a method using an observation auxiliary device called a “stereoscopic viewer”. There are a parallel method and an intersection method in stereoscopic vision with naked eyes, and in the parallel method, an image for the left eye is arranged on the left side, an image for the right eye is arranged on the right side,
Conversely, in the intersection method, the image for the left eye is arranged on the right side, and the image for the right eye is arranged on the left side. As a method for realizing this, a lens or a mirror provided in the optical adapters 5 and 6 is used.
Alternatively, there are mechanical methods that rotate the high-vision cameras 2 and 3 themselves, and electronic methods that use a frame memory and a video synthesizing device.
【0018】いずれにしても、5−ALAを使った蛍光
染色による癌組織の同定画像を、手術顕微鏡1の実野像
に合成して確認することができるため、癌組織の色区別
性が高まり、術中における癌組織を逐次正確に把握でき
るようになる。従って、正常な組織を傷つけることなく
1回の手術で過不足なく癌組織だけを確実に除去するこ
とができる。In any case, since the identification image of the cancer tissue by the fluorescent staining using 5-ALA can be synthesized and confirmed with the real image of the operating microscope 1, the color discrimination of the cancer tissue is improved. In addition, the cancer tissue during the operation can be sequentially and accurately grasped. Therefore, it is possible to reliably remove only the cancer tissue in one operation without damaging the normal tissue.
【0019】しかも、必要により、CTやMRIの映
像、経過映像、CG映像、超音波ナビゲーターによる超
音波誘導映像等の医療情報11も合成することができる
ため、更に底侵襲で効率的な手術ができ、手術時間が短
縮される。Furthermore, if necessary, medical information 11 such as CT and MRI images, progress images, CG images, and ultrasonic guidance images by an ultrasonic navigator can be synthesized, so that more efficient surgery can be performed with a base invasion. Operation time is reduced.
【0020】また、手術顕微鏡1の接眼部を覗いて観察
するのではなく、ハイビジョン液晶モニター9に表示し
て観察するため、主術者は無理のない楽な姿勢で手術を
行うことができ、主術者側における肉体的負担も軽減す
ることができる。Further, since the observation is performed by displaying the image on the high-definition liquid crystal monitor 9 instead of observing the eyepiece of the operating microscope 1 and observing it, the main surgeon can perform the operation in a comfortable and comfortable posture. Also, the physical burden on the main operator can be reduced.
【0021】尚、以上の実施形態では、手術顕微鏡1を
例にしたが、本発明は立体視を必要とする内視鏡に適用
することも可能である。また、ハイビジョン液晶モニタ
ー9を、ハイビジョンのCRTモニターに代えても良
い。更に、センサーカメラ4や切替器7は、一方のハイ
ビジョンカメラ3と別体である必要はなく、このハイビ
ジョンカメラ3の内部に一体的に組み込んでも良い。In the above embodiment, the surgical microscope 1 has been described as an example. However, the present invention can be applied to an endoscope requiring stereoscopic vision. The high-vision liquid crystal monitor 9 may be replaced with a high-vision CRT monitor. Further, the sensor camera 4 and the switching device 7 do not need to be separate from the one high-definition camera 3, and may be integrated inside the high-definition camera 3.
【0022】[0022]
【発明の効果】本発明によれば、5−ALAを使った蛍
光染色による癌組織の同定画像を、顕微鏡又は内視鏡の
ハイビジョンカメラによる実野像に合成して確認するた
め、癌組織の色区別性が高まる。従って、術中における
癌組織を逐次正確に把握できるようになり、正常な組織
を傷つけることなく、1回の手術で過不足なく癌組織だ
けを確実に除去することができる。According to the present invention, an identification image of a cancer tissue by fluorescent staining using 5-ALA is synthesized with a real image by a high-definition camera of a microscope or an endoscope to confirm the image. Color distinction is enhanced. Therefore, the cancer tissue during the operation can be sequentially and accurately grasped, and it is possible to reliably remove only the cancer tissue by one operation without damaging the normal tissue.
【図1】 本発明の一実施形態に係る癌組織摘出手術用
の立体視システムを示す図である。FIG. 1 is a view showing a stereoscopic system for cancer tissue resection surgery according to an embodiment of the present invention.
1 手術顕微鏡 2、3 ハイビジョンカメラ 4 センサーカメラ 5、6 光学アダプター 7 切替器 8 可動ミラー(切替手段) 9 ハイビジョン液晶モニター 10 コンピュータ 11 医療情報 A 立体撮像系 B センサー映像合成系 C 立体映像表示系 DESCRIPTION OF SYMBOLS 1 Surgical microscope 2, 3 High-definition camera 4 Sensor camera 5, 6 Optical adapter 7 Switch 8 Movable mirror (switching means) 9 High-definition liquid crystal monitor 10 Computer 11 Medical information A Stereoscopic imaging system B Sensor image synthesis system C Stereoscopic image display system
───────────────────────────────────────────────────── フロントページの続き (51)Int.Cl.7 識別記号 FI テーマコート゛(参考) G02B 21/36 G02B 21/36 (72)発明者 山口 孝一 神奈川県横浜市中区根岸旭台70番地2 (72)発明者 佐久間 一郎 神奈川県横浜市保土ヶ谷区川島町719番地 24 (72)発明者 土肥 健純 東京都世田谷区中町2−6−30 Fターム(参考) 2H052 AA13 AB19 AF14 AF21 4C061 BB06 WW04 WW17 ──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. 7 Identification symbol FI Theme court ゛ (Reference) G02B 21/36 G02B 21/36 (72) Inventor Koichi Yamaguchi 70-2 Negishi Asahidai, Naka-ku, Yokohama-shi, Kanagawa 72) Inventor Ichiro Sakuma 719 Kawashima-cho, Hodogaya-ku, Yokohama 24, Japan
Claims (3)
からの左右の像を立体的に撮影する2つのハイビジョン
カメラと、顕微鏡又は内視鏡と同じ視野の中から5−A
LAを吸収した癌組織の蛍光染色を撮影するセンサーカ
メラと、ハイビジョンカメラの片方とセンサーカメラと
を切替える切替手段と、を有する立体撮像系と、 センサーカメラの映像を保持してハイビジョンカメラの
映像に合成するセンサー映像合成系と、 ハイビジョンカメラの映像、センサーカメラの映像、セ
ンサーカメラの映像を合成したハイビジョンカメラの映
像を表示可能な立体映像表示系と、 から構成される癌組織摘出手術用の立体視システム。1. A microscope or an endoscope, two high-definition cameras for stereoscopically photographing left and right images from the microscope or the endoscope, and 5-A from the same field of view as the microscope or the endoscope.
A three-dimensional imaging system having a sensor camera for photographing fluorescent staining of LA-absorbed cancer tissue, a switching means for switching between one of the high-definition cameras and the sensor camera, and an image of the high-definition camera holding the image of the sensor camera A stereoscopic image for surgery to remove cancer tissue, consisting of a sensor image synthesizing system that synthesizes, and a stereoscopic image display system that can display the image of the high-definition camera, the image of the sensor camera, and the image of the high-definition camera that combines the image of the sensor camera. Vision system.
視システムであって、 切替手段が、片方のハイビジョンカメラとセンサーカメ
ラとを顕微鏡又は内視鏡に取付けるアダプター内に設置
された可動ミラーであることを特徴とする癌組織摘出手
術用の立体視システム。2. The stereoscopic system for cancer tissue resection surgery according to claim 1, wherein the switching means is provided in an adapter for attaching one of the high-definition camera and the sensor camera to a microscope or an endoscope. A stereoscopic system for surgical removal of cancer tissue, which is a mirror.
手術用の立体視システムであって、 センサー映像合成系において、立体映像表示系で表示さ
れる立体映像に関連する医療情報を含む映像も合成する
ことを特徴とする癌組織摘出手術用の立体視システム。3. The stereoscopic system for cancer tissue resection surgery according to claim 1, wherein the sensor image synthesizing system includes medical information related to a stereoscopic image displayed on the stereoscopic image display system. A stereoscopic system for surgical removal of cancer tissue, which also combines images.
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| JP2001123044A JP2002315721A (en) | 2001-04-20 | 2001-04-20 | Stereoscopic system for enucleation of cancer tissue |
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| JP2001123044A JP2002315721A (en) | 2001-04-20 | 2001-04-20 | Stereoscopic system for enucleation of cancer tissue |
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