JP2002265977A - Perfume composition capable of activating sympathetic nerve - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a new perfume composition having a slenderizing effect. SOLUTION: This perfume composition capable of activating sympathetic nerve and having a slenderizing effect contains one or two or more components selected from a fennel oil, a grapefruit oil, a pepper oil, a hyssop oil, a sage oil, an estragon oil, a eucalyptus oil, a rosemary oil, a cinnamon oil, a clove oil, an ilang-ilang oil, a ginger oil, a geranium oil and an olibanum, or the active constituents of the above-mentioned oils, i.e., limonene, pinene, myrcene and benzyl benzoate, and preferably also contains caffeine.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a perfume composition for activating a sympathetic nerve. More particularly, it relates to a sympathetic nerve-activating fragrance containing at least one or more essential oils.

[0002]

2. Description of the Related Art The autonomic nervous system is classified into a sympathetic nervous system and a parasympathetic nervous system based on differences in their functions, and mutually regulates the function of each organ or organ. Among them, the activation of the sympathetic nervous system is known to exert various effects such as an increase in heart rate, suppression of gastrointestinal activity, and is also caused by a mental state while being affected by hormones and the like. On the other hand, it is traditionally well known that fragrances exert various mental effects, and scents that calm the mind and enhance scent have long been known.

[0003] In recent years, their sedative and arousal effects have been demonstrated by brain wave measurements and the like. The fact that fragrances have various effects on the whole body system, including mental effects, has been clinically conducted around the world as "aromatherapy". However, the effect of fragrances on the autonomic nervous system is to activate the parasympathetic nervous system. At present, only a part of fragrances to be converted into fragrances has been reported, and no fragrances acting on the sympathetic nervous system have been found so far (JP-A-11-209294).

[0004]

In a stressful modern society, it has been desired to provide a sympathetic nervous system activator having few side effects as an autonomic nervous system regulator which is deeply involved in maintaining homeostasis of a living body.

[0005]

Means for Solving the Problems The inventors of the present invention have conducted intensive studies to solve the above-mentioned problems, and as a result, have found that a fragrance of a certain fragrance has a sympathetic nerve activating effect, and completed the present invention. . That is, the present invention relates to a sympathetic nerve activating fragrance comprising at least one kind of fragrance as an active ingredient, and an external preparation for skin and miscellaneous goods characterized by containing them as an active ingredient.

[0006] The fragrance here refers to fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil or It is preferably Oribanum, and these flavors may be used in combination. Also,
It preferably contains limonene, pinene, myrcene or benzyl benzoate, and these fragrances can be used in combination.

Accordingly, the present invention provides fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and Characterized by containing one or more selected from Olibanum, or containing one or more selected from limonene, pinene, myrcene and benzyl benzoate, activating sympathetic nerves A perfume composition is provided. The present invention further provides a skin external preparation composition or miscellaneous goods comprising the above-mentioned perfume composition as an active ingredient.

The present invention further provides fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and A slimming fragrance composition comprising one or more selected from Olibanum, or one or more selected from limonene, pinene, myrcene and benzyl benzoate. Offer things.

The present invention further provides fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and A memory-enhancing fragrance composition characterized by containing one or more kinds selected from Olibanum, or containing one or more kinds selected from limonene, pinene, myrcene and benzyl benzoate. Offer things.

The present invention further relates to fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and A method of slimming, characterized in that one or more kinds selected from Olibanum are bent, or one or more kinds selected from limonene, pinene, myrcene and benzyl benzoate are contained. provide. The present invention further provides a slimming composition comprising the above-mentioned sympathetic nerve activating fragrance composition as an active ingredient. Preferably, the composition further contains caffeine.

[0011]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail. Method for producing essential oil Pepper oil Pepper oil is obtained by steam-distilling an immature berry of a Piper genus plant belonging to the family Pepper, with a dried and blackened outer skin. The fragrance has an exciting refreshing sensation and is widely used as a spice for food all over the world (from Japan Fragrance Association, edited by "Aroma Encyclopedia").

Clove oil clove is an evergreen tree of the family Myrtaceae and is called "cushi" in Chinese medicine. The flower buds before flowering are picked, dried well and steam-distilled are called clove bud oil, and those obtained by steam distillation from leaves or twigs are called clove leaf oil, all of which are used as fragrances for cosmetics and foods. . EU
It has a woody, spicy scent with genol as the main ingredient (edited by the Japan Fragrance Association, "Encyclopedia of Scents").

Estragon oil Estragon is an Artemisia drue belonging to the genus Artemisia of the family Asteraceae.
It is also used in French escargot cuisine in unculus. All the above-ground parts of the flowering season grown in Europe and North America are cut, dried and subjected to steam distillation to obtain oil. The main component of the fragrance is Estragole, which has a sweet anise-like fragrance (from "Fragrance Encyclopedia", edited by Japan Fragrance Association).

Hyssop Oil Hyssop is a plant belonging to the genus Perilla in the Labiatae family, and has been used as a pharmaceutical since ancient times. The leaves and spikes are cut off and steam distilled to obtain a refreshing oil (from "Perfume Encyclopedia", edited by Japan Fragrance Association).

[0015] Sage oil sage is a herb classified in the Labiatae family of the genus Lamiaceae, and is widely distributed throughout the world. The oil is obtained by steam distillation of the dried leaves and has a fresh herbal aroma. It is also widely used as a spice for food in various parts of the world (from Japan Fragrance Association, “Encyclopedia of Fragrances”).

Eucalyptus oil Eucalyptus is an evergreen tree belonging to the family Myrtaceae and is also important as wood. Various types are distributed in the tropics and subtropics, and dried leaves and twigs are subjected to steam distillation to obtain an oil (from "Perfume Encyclopedia", edited by Japan Fragrance Association).

Grapefruit Oil Grapefruit is a so-called Citrus paradis Macf., An evergreen tree of the Rutaceae family native to the West Indies. It is a fruit with a refreshing sweetness and bitterness. The main fragrance is limonene, which has a unique citrus scent (from "The Encyclopedia of Fragrances", edited by Japan Fragrance Association).

[0018] fennel oil fennel belongs to the Umbelliferae, Yo is referred to as fennel or small fennel - has been used from prehistoric times as a medicinal herb in Europe native perennial. It was introduced to Japan during the Heian period and is now widely cultivated worldwide. The fruit has aroma and sweetness, and the essential oil is obtained by steam distillation. The main component of essential oil has a sweet aroma unique to anethole (edited by Japan Fragrance Association,
"From the Encyclopedia of Fragrance").

Rosemary oil Rosemary oil is an evergreen shrub of the Labiatae (scientific name: Rosmarinus officinalis) which is widely distributed in Mediterranean countries.
It is a refreshing sweet scent obtained by steam distillation of leaves and flowers. It is widely used as an active ingredient of pharmaceuticals and as a flavoring agent or a flavoring agent for cosmetics (from "Aroma Encyclopedia").

Ylang-ylang oil Ylang-ylang is obtained by steam distillation of a plant belonging to the family Annonaceae (Canning odorata) as it is, or by solvent extraction of a fresh flower with petroleum ether or the like. One of the most important fragrance plants known since ancient times, it has a floral aroma reminiscent of mild jasmine. It is also used as a harmony for fragrances and fragrances for foodstuffs (from "Scent Encyclopedia").

Cinnamon Oil Cinnamon is an evergreen Takagi tree of the camphoraceae family native to Southeast Asia, and its aroma is characterized by a sweet aroma and a slightly astringent stimulating taste. Cinnamon oil can be obtained by crushing the skin and subjecting it to steam distillation, but can also obtain oil by separately steam-distilling leaves and twigs. Utilizing the characteristics of each form, it is widely used in foods, cosmetics, and pharmaceuticals (from "Encyclopedia of Aroma").

Ginger oil Ginger oil is a perennial herb ginger (Zingiber officinale) of the ginger family which is also used for cooking as it is.
Roscoe) is obtained by drying the rhizome and subjecting it to steam distillation. The flavor varies slightly depending on the place of origin, and depending on its characteristics, it is used in beverages, meat storage products, seasonings, etc. (from "Aroma Encyclopedia").

Geranium Oil Geranium is a member of the family Anthracidae (Pelarg).
geranium oil is obtained by collecting its branches and leaves before the flower opens, leaving it for about one day, and then steam distilling it. is there. Because of the strong rose-like smell,
It can be used in all compounded fragrances, is stable in alkaline medium and does not change its odor, and is often used for perfuming high-grade soaps and detergents (from "Encyclopedia of Scents").

[0024] olibanum northeast America, South Arabia, also native to the poor soils of India, Furousou eyes Burseraceae Geraniales Burseraceae
Resin exuding from the bark of shrubs and small trees such as Boswellia carterii Birdw. Also known as Frankincense or frankincense. The fragrance of the resin itself is weak, but when it is lit on fire, it emits a very strong and unique fragrance, which has long been used during religious ceremonies. Resinoids and the like obtained by extracting an organic solvent from this resin are used for oriental-like compounded fragrances (from "Scent Encyclopedia").

Description of Other Raw Materials Representative limonene monocyclic terpene. Colorless liquid. It is an optical isomer of dextrorotatory d (+)-and levorotatory l (-)-. α-isomer fractionates essential oils obtained by steam distillation of pericarp such as oranges and lemons.
The body is obtained from peppermint oil (from synthetic perfume chemistry and product knowledge by Motoichi Indo, Chemical Daily). It is a representative of pinenterpene-based hydrocarbons and is contained in many essential oils, especially in pinnaceae.

It is produced in large quantities by the thermal decomposition of myrcene β-pinene. Naturally, it is present in bay oil, verbena oil, hop oil, galvanum oil, lemongrass oil and the like. It is a colorless to light brown liquid with a sweet balsam or resinous odor. Benzyl benzoate benzyl benzoate . True Balsam, Peruvian Balsam,
It is present in jasmine oil, cinnamon oil, cananga oil and the like. Colorless liquid with slightly floral and sweet balsam-like aroma. It is widely used as a retention agent and modulator in heavy floral or oriental compounded fragrances and as a solvent for balsams and resinoids.

The amount of these essential oils in the present invention is appropriately selected depending on the type of essential oil to be selected, the relationship with other components, and the like, and is not particularly limited. Usually, it is used in an amount of 0.001 to 100% by weight, preferably 10 to 100% by weight in the flavor composition (in the flavor formulation). The composition of the present invention is, for example, a cosmetic composition, a pharmaceutical composition, a fragrance composition for external preparations on the skin such as quasi-drugs, an incense composition, a fragrance composition for miscellaneous goods such as a space spray, and a beverage, a fragrance composition for food. However, the present invention is not limited to these uses. In addition to the above-mentioned sympathetic nerve-activating fragrance, a general fragrance component can be blended according to a specific mode that the present composition can take as long as the effects of the present invention are not impaired. In addition, sympathetic activation is known to cause slimming and improved memory, and the above essential oil compositions can be used for such applications.

The fragrance composition of the present invention can be used alone by itself, and may further contain other sympathetic activators such as capsaicin, zingerone, piperine and the like, and / or other anti-obesity / slimming ingredients such as Xanthin derivatives such as caffeine, Chinese tea, green tea extract, fennel, peonies, ginger, lavender, red pepper and other crude drugs, tamarind, gymnema sylvester, inosit,
It can be used in combination with dextran sulfate or the like.

In particular, when the present invention is used for slimming, the slimming effect can be further enhanced by using it in combination with caffeine. In other words, due to the synergistic effect of noradrenaline and caffeine secreted into the body by activating the sympathetic nerve,
Fat burning occurs, resulting in a higher slimming effect. This synergistic effect is evident, for example, from Example 2 and Example 3. In Example 2, it is apparent that the fragrance composition of the present invention increases blood catecholamines (adrenaline and noradrenaline). Further, in Example 3, it is apparent that the increase in the expression of uncoupling protein-3 by noradrenaline and caffeine occurs synergistically.

As described in the specification of Japanese Patent Application No. 2001-258346, weight loss occurs by energy consumption (fat consumption) by uncoupling protein-3. Therefore, it is reasonably estimated that the addition of caffeine to the fragrance composition of the present invention produces a synergistic slimming effect. In addition,
The composition of the perfume composition of the present invention and caffeine may be a mixture of these. When such a mixture is applied to the skin, the aroma components evaporate and are smelled from the nose, and caffeine is absorbed transdermally.

The compounding amount of caffeine is 0.00
1 to 5% by weight is blended. As a guide of the fragrance perfume rate,
It is as follows. Product type Perfume flavoring rate Lotion 0.001 to 0.05 Emulsion 0.03 to 0.2 Cream 0.05 to 0.2 Gel 0.005 to 0.2 Aerosol 0.001 to 30 Bath agent 0.2 to 3 Fragrance / room fragrance 1 to 100 Incense 1 to 30 Foam pack 0.03 ~ 0.2

Evaluation of Autonomic Nerve Activity Autonomic nerves are roughly classified into sympathetic nerves and parasympathetic nerves, and regulate internal organs and glands. At that time, it is adrenaline and acetylcholine released from nerve endings that directly act on glands and muscles, and the heart, blood vessels, pupils, gastrointestinal activity,
It regulates the activities of sweat glands and the like almost antagonistically. Therefore, various methods for measuring autonomic nervous activity include methods for directly measuring adrenaline and acetylcholine levels, and methods for measuring heart rate, blood flow / blood pressure, sweating, pupil reaction, etc. Gaku ”Fukumura Publishing). In measuring the effect of the fragrance on the autonomic nervous system, the measuring method is not particularly limited as long as it is an appropriate method.

[0033]

The present invention will be described below in detail with reference to examples, but the present invention is not limited to these examples. Embodiment 1 FIG. Measurement of Sympathetic Nerve Activity The heartbeat interval (pulsation interval) or blood pressure fluctuation (blood pressure fluctuation) fluctuates in a complicated manner even at rest, and is governed by a plurality of systems represented by the sympathetic nerve and parasympathetic nerve. Therefore,
It is known that the activity of each system can be calculated by frequency analysis of the pulsation interval or blood pressure fluctuation. The high frequency component of heart rate variability indicates parasympathetic nervous activity, and the low frequency component indicates mixed activity of the sympathetic nervous system and parasympathetic nervous system, while the low frequency component of blood pressure variability indicates sympathetic nervous activity (Dainippon Pharmaceutical) .

Therefore, the sympathetic nerve activity was measured by analyzing systolic blood pressure fluctuation using an autonomic nervous system activity analysis system (Fraclet, manufactured by Dainippon Pharma Co., Ltd.). After resting in a constant temperature room at room temperature of 24 ° C. for 5 minutes, the upper arm blood pressure value was measured, the blood pressure value of the wrist was corrected, and then the blood pressure was continuously measured from the wrist. At the start of the measurement, cotton was placed under the nose and blood pressure was measured for 3 minutes without scent. Then, the scent was soaked in the cotton under the nose and the blood pressure was measured for 3 minutes. Obtain the low-frequency component of the measured systolic blood pressure fluctuation, calculate the sympathetic nerve activity, and calculate the relative value of the sympathetic nerve activity when there is a scent (the latter three minutes) with no scent (the first three minutes), and the sympathetic nerve of the scent Was measured.

Fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil,
When presenting estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang-ylang oil, ginger oil, geranium oil, oribanum, it is 1.2 ~
A 3.0-fold activation of the sympathetic nerve was observed (FIG. 1). When TEC (triethyl citrate) with no smell was presented, the relative value of sympathetic nerve activity did not change. Furthermore, as a result of conducting GC / MS analysis of the fragrance which activated the sympathetic nerve, limonene, pinene, myrcene and benzyl benzoate were found as components common to these fragrances. As for these fragrance components, the sympathetic nerve activity when smelling the scent was measured in the same manner, and as a result, an effect of increasing the sympathetic nerve activity was found (FIG. 2).

Comparative Example 1 Against the essential oils having an activating effect, rose oil, mill oil, marjoram oil, juniper berry oil, patchouli oil and the like had an effect of calming the sympathetic nerve activity (FIG. 1). The attractive and pleasant aroma of rose oil roses is now well known and recognized around the world. Since ancient times it has been regarded as the Queen of Flowers. Rose oil is characterized by its strength, fragrance lift and gorgeousness compared to absolute, and is often used for floral bases, shipplies, and oriental bases (from "Encyclopedia of Scents").

Mill oil Mainly Geranial
es Resin exuding from the bark of Burseraceae Commiphora.
There are more than 60 species of genus
The sap that oozes from the bark wounds comes into contact with the air and forms a deep, sweet, spicy, balsam-like mass. As a compounding flavor, it is often used for oriental ones, and for flavors, a mouthwash utilizing its bitterness and spiciness,
It is used as a toothpaste (from "Scent Encyclopedia").

Marjoram Oil Marjoram is a plant of the Labiatae native to the eastern coast of the Mediterranean Sea, and typical examples include sweet marjoram (Origanum majorana) and Spanish wild marjoram. Marjoram is widely cultivated in temperate regions and is mainly used as a spice. In addition, it is used as a perfume, fragrance, colon, oriental base (from "Encyclopedia of Aroma")

Juniper berry oil Juniper is a member of the genus Cyperaceae (Juniperius).
communis L.), an evergreen tree with a height of 3 m. It is widely wild in Europe, Asia and North America. Obtain oil from Juniper's ripe blue-black two-year-old fruit. The oil has a balsamic, woody, pine needle-like aroma and is used in the aroma of Western liquors, drinks, oral fresheners, etc. (from "Aroma Encyclopedia").

Patchouli oil Patchouli is a perennial herb belonging to the Labiatae native to southern Asia and has almost no smell when fresh leaves, but smells when dried. Oil is obtained mainly by direct-fired distillation, and its heavy, oriental image scent is widely used for floral and citrus scents.

Comparative Example 2 The effects of the essential oil scent and the hot water extract scent on the sympathetic nerve activity were compared. The essential oil is pepper oil. As the hot water extract, black pepper and green pepper hot water extracts prepared according to a conventional method were used. as a result,
Compared to the high effect on the scent of essential oils, no effect was found on the scent of hot water extract, indicating that the scent components contained in the essential oils greatly contributed to the activation of sympathetic nerves (Fig. 3).

Embodiment 2 FIG . Due to the fragrance of the sympathetic activating fragrance
Increase in blood catecholamines Among the fragrances that activate the sympathetic nerves, pepper oil and grapefruit oil were taken as examples, and changes in blood catecholamines concentration by smelling the fragrance of these fragrances were examined. Twelve subjects smell the aroma of pepper oil or grapefruit oil, respectively.
The concentrations of catecholamines in blood were compared before smelling and after smelling for 7 minutes. After the subject was seated in a chair and kept at rest for 30 minutes, 5 ml of blood was collected,
The sample before the presentation of the scent was used.

Under the subject's nose while resting,
Attached absorbent cotton impregnated with essential oil to smell the scent, 7
Five minutes later, 5 ml of blood was collected again to obtain a sample showing the scent. A blood collection tube containing ADTA.2NA was used for blood collection. The collected blood sample should be immediately
The plasma was collected by centrifugation for 0 minutes and stored frozen until the time of measurement. Catecholamines in plasma were measured using a post-column fluorescence reaction HPLC method using diphenylethylenediamine, a fluorescent reagent that specifically reacts with catechol nuclei, from a deproteinized plasma sample using a catecholamine analyzer (Tosoh, HLC- 8030).

FIG. 5 shows the results. As is clear from the figure, compared to before the scent presentation, after smelling the scent of pepper or grapefruit, catecholamines such as adrenaline and noradrenaline are increasing, the scent of these fragrances activates the sympathetic nerve activity, It has been clarified that the secretion of catecholamines such as adrenaline and noradrenaline is promoted.

Embodiment 3 FIG . Catecholamines (Norad
Synergistic effect of renalin and caffeine Noradrenaline (0.5
μg / ml), caffeine (1m
M) itself enhances uncoupling protein-3 expression, but noradrenaline (0.5 μg / ml) and caffeine (1 m
The simultaneous addition of M) synergistically increased the expression of uncoupling protein-3.

Embodiment 4 FIG . Examination of slimming effect by continuous test
The slimming effect was confirmed using the emulsion described after the proof (Formulation Example 5). Twenty women aged 20 to 30 years old were allowed to use the emulsion for a month on the body every day for one month, and the changes in body weight, circumference (waist, hips 9) before and after the continuous test were compared. The results are shown in Table 1 below. It was as follows.

[0047]

[Table 1] As is clear from Table 1, the weight, waist length and hip length significantly decreased after continuous use, and the slimming effect of the present invention was confirmed.

Formulation Examples In the formulation examples,% means mass%. Fragrance (1) Alcohol 75% (2) Purified water residue (3) Dipropylene glycol 5% (4) Perfume of the present invention 10% (5) Antioxidant appropriate amount (6) Grapefruit oil 5% (7) Pigment appropriate amount ( 8) Suitable amount of UV absorber

Here, the “fragrance” is a substance obtained by dissolving the grapefruit oil of the present invention in alcohol (for example, ethyl alcohol) or aqueous alcohol.
Fragrance is the grapefruit oil 1 of the present invention
Contains 99% by mass. The mixing ratio of water and alcohol is 50:
The range is 50 to 0: 100. Fragrances can contain solubilizers, softeners, humectans, thickeners, bacteriostats, or other materials commonly used in cosmetics. Using ordinary flavoring means, further add a flavor component that is in harmony with the grapefruit oil of the present invention and modulate it, and finish by adding a retaining property or body, or properly add a top note, middle note, last note Combinations can be made into formulations that emit an attractive aroma over time.

For example, an example of a combination of these essential oils exhibiting sympathetic activity is the formulation shown in Formulation Example 1. As a result of comparing the influence of the prescription flavor on the sympathetic nerve activity, a high sympathetic nerve activating effect was recognized (FIG. 4).

[0051]

Formulation Examples 2 and 3 of Novel Flavor No. Formulation Example 2 Formulation Example 3 (1) Grapefruit oil 10.0 5.0 (2) Estragon oil 32.0 30.0 (3) Fennel oil 8.0 1.0 (4) Pepper oil 0.1-(5) ) Hyssop oil 0.1-(6) Bergamot 1.0-(7) CIS-3-hexonol 2.0 0.7 (8) Cis-3-hexenyl acetate 1.0 0.3 (9) Tripral 2.0 0.7 (10) Tomato base 3.0 1.0 (11) Styralyl Acetate 2.0 0.7 (12) Rifarol 3.0 1.0 (13) Caron 1.0 1.0 (14) Linalool 10.0 10.0 (15) Benzyl acetate 1.0 1.0 (16) Hedion 0.5 0.5 (17) β-ionone 1.0 1.0 (18) Menthol 10.0 10.0 ( 19) Musk 1.0 5.0 (20) Triethyl citrate 11.3 31.1

Formulation Examples 4 and 5 of Novel Flavor No. Formulation Example 4 Formulation Example 5 (1) Grapefruit oil 200 200 (2) Linalool 20 20 (3) Linalyl acetate 10 20 (4) Pepper oil 100 20 (5) Fennel oil 20 10 (6) Estragon oil 10 10 (7) Sage oil 20 20 (8) Helional 20-(9) Manzanate 20-(10) hedion 150 150 (11) Dihydromyrcenol 50-(12) Galaxolide 50 50 (13) bergamot oil 50 50 (14) limonene 140 140 (15) cis-3-hexenol 1- (16) helional 2- (17) allyl amyl glycolate 2- (18) α-hexylcinnamic aldehyde − 40 (19) Phenylethyl alcohol − 20 (20) Lilyal − 20 (21) Lylal − 20 (22) β-ionone − 20 (23) Methyl ion Emission gamma - 30 (24) Geraniol - 30 (25) Citronellol - 20 (26) dimethylbenzyl carbonyl acetate - 50 (27) Dipropylene glycol 135 70 Total 1,000 1,000

As an external preparation for skin (cosmetics), it is used for various extracts such as trimethylglycine, brown algae extract, red algae extract, green algae extract, tocopherol acetate, natto extract, dokudami extract, and external preparations for skin such as dipotassium glycyrrhizinate. Various drugs that can be used can be compounded.

Toner (Formulation Example 1) (1) Glycerin 2% (2) Dipropylene glycol 2% (3) PEG-60 hydrogenated castor oil 0.3% (4) Trimethylglycine 0.1% (5) Preservative (6) ) Chelating agent appropriate amount (7) dye appropriate amount (8) perfume of the present invention appropriate amount (9) purified water balance

Lotion (Formulation Example 2) (1) Alcohol 30% (2) Butylene glycol 4% (3) Glycerin 2% (4) PPG-13 decyltetrades 24 0.3% (5) Octyl methoxycinnamate 0.1% (6) Menthol 0.2% (7) Tocopherol acetate 0.1% (8) Suitable amount of chelating agent (9) Suitable amount of dye (10) Suitable amount of fragrance of the present invention (11) Remaining amount of purified water

Emulsion (Formulation Example 1) (1) Ethyl alcohol 10% (2) Cyclomethicone 0.1% (3) Butylene glycol 5% (4) Dimethicone 3% (5) Glycerin 0.1% (6) Menthol 1% (7) ) Trimethylsiloxysilicate 0.1% (8) Caffeine 1% (9) Trimethylglycine 1% (10) Xanthan gum 0.001% (11) Hydroxyethylcellulose 0.1% (12) Soybean fermented extract 1% (13) Lauryl betaine 0.5% ( 14) Brown algae extract 1% (15) Red algae extract 1% (16) Green algae extract 1% (17) Carbomer 0.2% (18) Chelating agent appropriate amount (19) Paraben appropriate amount (20) Benzoic acid appropriate amount (21) The present invention Perfume Appropriate amount (22) Iron oxide Appropriate amount (23) Caustic potassium 0.05% (24) Dipotassium glycyrrhizinate 0.01% (25) Pyridoxine hydrochloride 0.01% (26) Glucos ascorbate 0.01% (27) 0.01% ascorbic acid (28) Arbutin 3% (29) Saxifraga extract 0.1% (30) Water Balance

Emulsion (Formulation Example 2) (1) Butylene glycol 4% (2) Propylene glycol 4% (3) Carbomer 0.2% (4) Caustic potassium 0.2% (5) Behenic acid 0.5% (6) Stearic acid 0.5% ( 7) Isostearic acid 0.5% (8) Glyceryl stearate 1% (9) Glyceryl isostearate 1% (10) Behenyl alcohol 0.5% (11) Bacyl alcohol 0.5% (12) Squalane 5% (13) Trioctanoin 3% ( 14) Phenyltrimethicone 2% (15) Dipotassium glycyrrhizinate 0.01% (16) Suitable amount of preservative (17) Suitable amount of chelating agent (18) Suitable amount of pigment (19) Suitable amount of fragrance of the present invention (20) Remaining amount of purified water

Emulsion (Formulation Example 3) (1) Glycerin 3% (2) Xylitol 2% (3) Carbomer 0.1% (4) Caustic potassium 0.1% (5) Glyceryl isostearate 1% (6) Glyceryl stearate 0.5% ( 7) Behenyl alcohol 1% (8) Bacyl alcohol 1% (9) Hardened palm oil 2% (10) Vaseline 1% (11) Squalane 5% (12) Erythrityl octoate 3% (13) Cyclomethicone 1% (14) Preservative proper amount (15) Chelating agent proper amount (16) Perfume residual amount of the present invention (17) Purified water residual amount (18) Tranexamic acid 1% (19) Pantothenyl ethyl ether 0.5% (20) Nicotinamide 0.1% ( 21) Trehalose 0.1% (22) Rosemary extract 0.1% (23) Vitamin A 0.1% (24) Ascorbic acid glycoside 0.001% (25) Raspberry extract 1% (26) E Gon extract 0.001% (27) bark extract 0.01%

Emulsion (Formulation Example 4) (1) Ethanol 2% (2) Cyclomethicone 10% (3) Glycerin 5% (4) Dibutylene glycol 1% (5) Dimethicone 1% (6) Corn starch 4% (7) ) Mineral oil 2% (8) Trimethylsiloxysilicic acid 5% (9) Polyethylene glycol 3% (10) Menthyl lactate 0.1% (11) PEG-60 hydrogenated castor oil 1% (12) Aminopropyl dimethicone 1% (13 ) Xanthan gum 0.01% (14) Tocopherol acetate 0.01% (15) Caffeine 0.1% (16) Sodium hyaluronate 0.1% (17) Xanthan gum 0.01% (18) Fermented soybean extract 0.01% (19) Hamamelis extract 0.01% (20) Dokudami extract 0.01% (21) Carbomer 0.3% (22) Alkyl acrylate alkyl methacrylate 0.2% (23) HEDTA appropriate amount (24) Preservative appropriate amount (25 ) Perfume of the present invention suitable amount (26) pigment proper amount (27) caustic potash 0.15% (28) aminomethylpropanol 0.05% (29) water remaining amount

Emulsion (Formulation Example 5) (1) Ethanol 15% (2) Cyclomethicone 6% (3) Butylene glycol 0.5% (4) Dimethicone 1% (5) Glycerin 1% (6) Polyethylene glycol 1 (7) Menthyl lactate 1% (8) Menthol 0.1% (9) Trimethylsiloxysilicic acid 1% (10) Caffeine 0.5% (11) Trimethylglycine 0.1% (12) Xanthan gum 0.1% (13) Hydroxyethyl cellulose 0.1% (14) Soy Fermented extract 0.01% (15) Tocopherol acetate 0.05% (16) Lauryl betaine 0.01% (17) Brown alga extract 0.01% (18) Dokudami extract 0.01% (19) Red algae extract 0.01% (20) Green algae extract 0.01% (21) Cellulose powder 1% (22) PEG-60 glyceryl isostearate 1% (23) Isostearic acid 1% (24) Carbomer 0.1% (25) Acrylic acid Alkyl acrylate copolymer 0.1% (26) EDTA 0.1% (27) Sodium metaphosphate 0.1% (28) Phenoxyethanol 0.2% (29) Paraben 0.2% (30) Fragrance of the present invention (Preparation example of compounded fragrance 1) 0.45 ( 31) Iron oxide (red) 0.02% (32) Menthyl glyceryl ether 0.01% (33) Water remaining

Cream (Formulation Example 1) (1) Glycerin 10% (2) Butylene glycol 5% (3) Carbomer 0.1% (4) Caustic potash 0.2% (5) Stearic acid 2% (6) Glyceryl stearate 2% ( 7) Glyceryl isostearate 2% (8) Vaseline 5% (9) Stearyl alcohol 2% (10) Behenyl alcohol 2% (11) Hardened palm oil 2% (12) Squalane 10% (13) 4-Methoxycalicylate 3.0% (14) Preservative appropriate amount (15) Chelating agent appropriate amount (16) Pigment appropriate amount (17) Perfume of the present invention appropriate amount (18) Purified water balance

Cream (Formulation Example 2) (1) Glycerin 3% (2) Dipropylene glycol 7% (3) Polyethylene glycol 3% (4) Glyceryl stearate 3% (5) Glyceryl isostearate 2% (6) Stearyl Alcohol 2% (7) Behenyl alcohol 2% (8) Liquid paraffin 7% (9) Cyclomethicone 3% (10) Dimethicone 1% (11) Octyl methoxycinnamate 0.1% (12) Na hyaluronate 0.05% (13) Preservative (14) Chelating agent (15) Pigment (16) Perfume of the present invention (17) Purified water

Gel (1) Ethyl alcohol 10% (2) Glycerin 5% (3) Butylene glycol 5% (4) Carbomer 0.5% (5) Aminomethylpropanol 0.3% (6) PEG-60 hydrogenated castor oil 0.3% ( 7) Menthol 0.02% (8) Preservative proper amount (9) Chelating agent proper amount (10) Perfume proper amount of the present invention (11) Purified water balance

Aerosol (Formulation Example 1) (1) Glycerin 2% (2) Dipropylene glycol 2% (3) PEG-60 hydrogenated castor oil 0.3% (4) HPPCD (hydroxypropyl β-cyclodextrin) 1.0% (5) Preservative appropriate amount (6) Chelating agent appropriate amount (7) Dye appropriate amount (8) Flavor of the present invention appropriate amount (9) Purified water balance (10) Nitrogen gas 0.8%

Aerosol (Formulation Example 2) (1) Alcohol 15% (2) Butylene glycol 2% (3) Glycerin 1% (4) PPG-13 decyltetrades 24 0.1% (5) Silver-loaded zeolite powder 1.0% ( 6) Suitable amount of chelating agent (7) Suitable amount of dye (8) Suitable amount of perfume of the present invention (9) Remaining amount of purified water (10) LPG 40%

Aerosol (Formulation Example 3) (1) Ethanol 60% (2) Menthyl lactate 0.1% (3) Sodium lactate 0.1% (4) Tocopherol acetate 0.01% (5) Lactic acid 0.01% (6) Caffeine 0.01% ( 7) Fennel extract 1% (8) Hamamelis extract 1% (9) Dokudami extract 1% (10) Dipropylene glycol 1% (11) Nitrogen gas 0.9 (12) Polyoxyethylene polyoxypropylene decyl tetradecyl ether 1% ( 13) Butylene glycol 2% (14) Tocopherol 0.05% (15) Appropriate amount of fragrance of the present invention (16) PEG-60 hydrogenated castor oil 0.1% (17) Water remaining amount

Bath agent (1) Sodium sulfate 45.0% (2) Sodium bicarbonate 45.0% (3) Hyssop oil 10.0% (4) Perfume of the present invention

Room fragrance (1) Alcohol 80.0% (2) Purified water residue (3) Antioxidant 5.0% (4) Appropriate amount of perfume of the present invention (5) 3-Methyl-3-methoxybutanol 5.0% (6) Dibenzylidene Sorbitol 5.0% (7) Sage oil 5.0%

[0070] Incense (1) tab powder 75.5% (2) Sodium benzoate 15.5% (3) Perfume Appropriate amount (4) 1.0% eucalyptus oil of the present invention (5) Fennel oil 1.0% (6) Purified water Balance

Massage gel (1) Erythritol 2.0% (2) Caffeine 5.0% (3) Ouba extract 3.0% (4) Glycerin 50.0% (5) Carboxy vinyl polymer 0.40% (6) Polyethylene glycol 400 30.0% (7) Ethylenediaminehydroxyethyl trisodium triacetate 0.1% (8) Polyoxyethylene (10) methylpolysiloxane copolymer 2.0% (9) Squalane 1.0% (10) Fennel oil 1.0% (11) Potassium hydroxide 0.15% (12) Purified water residue

Foam pack (1) Caffeine 1.0% (2) Sodium metaphosphate 0.02% (3) Trehalose 2.0% (4) Glycerin 7.0% (5) Methyl paraben 0.11% (6) Potassium hydroxide 0.15% (7) Stearin Acid 0.5% (8) Myristic acid 1.0% (9) Bacyl alcohol 1.5% (10) Polyoxyethylene (60) Hardened castor oil 3.0% (11) Pepper oil 0.3% (12) Liquefied petroleum gas 6.0% (13) Dimethyl ether 3.0% (14) Appropriate amount of the fragrance of the present invention (15) Residual water

[0073]

According to the present invention, a sympathetic nerve activating composition having no side effects can be provided, and further, a slimming composition and a memory improving composition are provided.

[Brief description of the drawings]

FIG. 1 is a graph showing sympathetic nerve relative activity by systolic blood pressure fluctuation analysis.

FIG. 2 is a graph showing sympathetic nerve relative activity by systolic blood pressure fluctuation analysis.

FIG. 3 is a graph showing the sympathetic relative activity of a hot water extract of pepper.

FIG. 4 is a graph showing the sympathetic nerve relative activity of a formulation (perfume formulation 1) in which essential oil having an effect of activating the sympathetic nerve is combined.

FIG. 5 is a graph showing an increase in catecholamines in blood due to the aroma of a sympathetic nerve activating fragrance.

FIG. 6 shows uncoupling protein in subcutaneous adipose tissue.
3 is a graph showing the synergistic effect of caffeine and noradrenaline on the expression of 3 genes.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 7/00 A61K 7/00 N 4H059 R SU 7/46 7/46 A 7/48 7/48 7 / 50 7/50 31/01 31/01 31/015 31/015 31/235 31/235 31/522 31/522 35/78 35/78 CK N Q T A61P 3/04 A61P 3/04 17 / 00 17/00 25/02 104 25/02 104 25/28 25/28 43/00 111 43/00 111 // A23L 1/22 A23L 1/22 C 1/221 1/221 C (72) Inventor Aizu Yoko 2-2-1 Hayabuchi, Tsuzuki-ku, Yokohama-shi, Kanagawa Prefecture Inside Shiseido Research Center (Shin-Yokohama) (72) Inventor Yukiko Koizumi 2-2-1 Hayabuchi, Tsuzuki-ku, Yokohama-shi, Kanagawa Shiseido Research Center (Shin-Yokohama) ) F term (reference) 4B047 LB03 LB08 LB09 LG05 LG11 LG12 LG37 LP01 4C083 AA032 A A112 AA121 AA122 AB032 AB082 AB232 AB282 AB312 AB352 AB442 AC011 AC012 AC022 AC031 AC032 AC072 AC102 AC112 AC122 AC132 AC172 AC242 AC262 AC302 AC312 AC341 AC342 AC422 AC432 AC442 AC482 AC532 AC542 AC582 AC622 AC642 AC712 AC851 AC852 AD912 AD332 AD212 AD212 AD12 AD392 AD532 AD622 AD642 AD662 CC04 CC05 CC07 CC50 DD08 DD23 DD27 DD31 DD41 EE06 EE41 EE50 4C086 AA01 AA02 CB07 MA01 MA02 MA03 MA04 MA07 MA09 MA63 NA14 ZA15 ZA25 ZA70 ZA89 ZC02 ZC21 4C088 AB12 AB26 AC33 AB38 AB36 AC11 AC12 BA08 CA15 MA07 MA63 NA14 ZA15 ZA25 ZA70 ZA89 ZC02 ZC21 4C206 AA01 AA02 BA02 BA03 KA01 KA08 MA01 MA02 MA03 MA04 MA11 MA17 MA83 NA14 ZA15 ZA25 ZA70 ZA89 ZC02 ZC21 4H059 BA01 BB05 BB15 BB52 BB15 BB52 DA09

Claims (11)

[Claims] 1. Select from fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and oribanam A sympathetic nerve activating fragrance composition comprising one or more of the above. 2. A sympathetic nerve activating fragrance composition comprising one or more selected from limonene, pinene, myrcene and benzyl benzoate. 3. A skin external preparation composition or miscellaneous goods comprising the sympathetic nerve activating fragrance composition according to claim 1 or 2 as an active ingredient. 4. A material selected from fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and oribanam. A slimming fragrance composition comprising one or more of the above. 5. A slimming fragrance composition comprising one or more selected from limonene, pinene, myrcene and benzyl benzoate. 6. Selected from fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and oribanam. A fragrance composition for improving memory ability, comprising one or more of the above. 7. A memory enhancing fragrance composition comprising one or more selected from limonene, pinene, myrcene and benzyl benzoate. 8. A material selected from fennel oil, grapefruit oil, pepper oil, hyssop oil, sage oil, estragon oil, eucalyptus oil, rosemary oil, cinnamon oil, clove oil, ylang ylang oil, ginger oil, geranium oil and oribanam. Slimming method characterized by bending one or more kinds of slimming. 9. A slimming method characterized by bending one or more selected from limonene, pinene, myrcene and benzyl benzoate. 10. A slimming composition comprising the sympathetic nerve activating fragrance composition according to claim 1 or 2 as an active ingredient. 11. The slimming composition according to claim 10, further comprising caffeine.