JP2002047182A - Composition for external application for improving fur quality of pet - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition for external application capable of supplying a necessary sufficient amount of radical scavenging component to the fur of a pet having fur or feather such as dog, cat or bird by scattering, coating, pasting or spraying to the pet animal, enabling the prevention, suppression or reduction of oxidation stress and improving the abnormal fur occurred and developed by radical. SOLUTION: The composition for external application for improving the fur quality of a pet contains a radical scavenging component having high concentration or a stabilized active radical scavenging component. More specifically, the composition contains a component selected from concentrated L-ascorbic acid as the radical scavenging component having high concentration and stabilized active ascorbic acid as the stabilized active radical component or a complex of both components and, at the same time, a component selected from bleaching preparation, anti-inflammatory agent, humectant and sterilizing agent or their complex.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to an external composition for making pet fur vivid and glossy.

[0002]

2. Description of the Related Art The hair of pets such as dogs, cats, birds and the like is continuously attacked by radicals such as active oxygen for 24 hours, and is oxidatively degraded little by little every day. Cells survive by producing oxygen by breathing oxygen and slowly burning and oxidizing it, but this oxygen also produces toxic substances such as active oxygen (also called radicals or free radicals) and causes hair growth. It is said to damage cells and cause aging of the hair produced therefrom. For example, it has been pointed out that animal species with more active oxygen metabolism generate more active oxygen and have a shorter life span. In addition, it is estimated that an average of 1000 or more molecules of DNA per cell are damaged by active oxygen per day, which naturally has an adverse effect on hair-forming cells, which are one of skin cells. The accumulation of hair-forming cell damage due to this active oxygen causes a phenomenon called “aging of hair”, which promotes a decrease in gloss and color of hair and other deterioration in quality of body hair.

[0003] In addition, active oxygen and ultraviolet light contained in dust and the like in the atmosphere oxidize lipids of the epidermis and body hair of pets such as dogs and cats,
Cleavage of peptide bonds in proteins such as keratin in the body hair, destroying the cuticle of the body hair, and promoting the aging of hair-forming cells in hair-growing tissues, resulting in deterioration of hair level, deterioration of pigment in the body hair, and luster of hair. It is thought that it is causing the deterioration of It also damages cells and tissues around hair-forming cells, exacerbates inflammation such as pustules and dermatitis, and causes various cell damages, such as DNA damage, carcinogenesis, and promotion of telomere gene cleavage, which cause hair loss and apoptosis. It is presumed to be the cause of aging and acceleration of aging. Dogs and cats have more hair than humans, do not wear clothes like humans, and they wash less frequently than baths compared to humans, so sulfur oxides and nitrogen in air and environmental exhaust gas and dust Many radical-generating substances such as oxides are adsorbed on body hair and left. In addition, in the case of pets, the number of hair-forming cells per unit skin area is larger than that of humans, so that the effects of radicals on hair-forming cells are so serious that they cannot be compared with human skin. Naturally, the number of pores is large in proportion to the number of hair-forming cells, and therefore, strong resistance to oxidative stress and infectious diseases caused by pores is required.

[0004] Hydrogen peroxide, hydroxyl radical, superoxide and the like are known as active oxygen generated in a living body, and include lipid hydroperoxide (lipid peroxide) which is an oxidized and damaged oil. It has been pointed out that a group of substances called radicals is a causative substance that promotes skin aging. Radicals such as lipid hydroperoxides need to be scavenged as soon as possible in order to cause a chain reaction and successively generate new radicals. Active oxygen and radicals are also produced in large quantities by factors such as exposure to ultraviolet light, chlorine in tap water, lipid peroxide in foods, and radical producing components contained in cosmetic raw materials. In recent years, pets have become closer to human living environments, and pets are increasingly exposed to harmful chemicals to which humans are exposed.
In addition, pets do not wear clothes or shoes and are directly exposed to harmful ultraviolet rays for a long period of time, and are often directly exposed to tars derived from asphalt etc. on paved roads. There is little chance that residual and deposited radical contaminants will continuously damage pet hair and skin hair-forming cells.

[0005] In addition, pets are bred in stressed environments such as small condominiums, resulting in an increase in cortisol in the pet body, depletion of ascorbic acid in the living body, an increase in active oxygen in the body, and a peroxidation state. Cause. Long-term exposure of pets exposed to such conditions to chlorine radicals from water supply, sulfur dioxide from automobiles, etc., formalin gas from apartment wallpaper and paint, tar on paved roads, ultraviolet rays, etc. When this occurs, not only oxidation of body hair is promoted, but also aging of hair growth cells is accelerated, deterioration of hair level, deterioration of gloss, hair loss, etc. are accelerated, and radical generating substances adhered to body hair remain for a long time in hair growth cells. It continues to damage and induces inflammation not only in the hair-forming cells but also in the surrounding cells, inducing pigmentation and, in severe cases, necrosis of the skin cells, damaging DNA and inducing skin cancer.

It has also been pointed out that many body hair abnormalities are caused by radicals. For example, as a hair abnormality that develops a disease due to a radical generating substance adsorbed on the body hair,
Deterioration of fur, furry fur, dropping or damage of cuticle structure, split ends, worsening of gloss, deterioration of hair color, bleaching of hair, loss of hair due to hair loss, decrease in the number of body hairs, deterioration of body hair strength, diameter of body hair In some cases, a decrease in the color of the hair and a decrease in the contrast of the hair color may be observed, and it is not difficult to imagine that the skin cells around the hair-forming cells are adversely affected.

[0007] As a defense mechanism against these radicals, a living body of an animal is provided with a defense system for eliminating the toxicity of active oxygen and radicals. Glutathione peroxidase, an enzyme that suppresses active oxygen existing in the body,
Catalase, superoxide dismutase (SOD)
Etc. are known. Many other natural radical scavengers such as vitamin C, vitamin E, carotenoids, polyphenols of tea and grape, and raspberry extract are known. However, it is believed that these endogenous radical scavenging systems do not work on the majority of hair that protrudes from the body surface except for the root hair and does not have fluid circulation.

[0008]

[0005] Conventional pet hair quality improving lotions for pets are almost always replenished by applying oil or fat to body hair to replenish the oil content or by adding a humectant to replenish moisture. However, addition of a component that copes with oxidative stress caused by radicals on body hair has not been performed. Some products have a low concentration of about 0.5% L-
Although ascorbic acid and about 0.05% of natural vitamin E were added, the purpose was to prevent the oxidation of the preparation components, not to prevent the oxidation of body hair, but to add L at such a low concentration. -Ascorbic acid and vitamin E were rapidly oxidatively decomposed, and the antioxidant effect could not be expected in severe pet hair.

That is, radical scavenging components such as L-ascorbic acid and natural vitamin E, which have been added to prevent the oxidation of lotions, have radical scavenging activity themselves and are added as storage stabilizers for the components. It is useful for radical scavenging of components in containers, but when released into the air, it is quickly oxidized and decomposed by oxygen in the atmosphere and deactivated, and it is said that radical scavenging effects on pet hair and hair growth cells can hardly be expected There was a problem.

[0010] For this reason, in the conventional pet body hair lotion, the use of the lotion promotes the oxidation of the replenished lipids and the presence of water, which in turn promotes the oxidation of the pet's body hair, and is temporary for a short time after the use of the lotion. Had a problem that it looked beautiful but accelerated the aging of body hair and hair-forming cells.

Therefore, a radical scavenging component such as ordinary L-ascorbic acid or natural vitamin E has poor stability even in the presence of a radical scavenging activity, so that it is blended in an external composition for improving body hair quality for pets such as cosmetics. However, there is a problem that the radical scavenging effect on body hair is not maintained.

[0012] In addition, ordinary radical scavenging components such as L-ascorbic acid and natural vitamin E oxidize themselves in a short period of time. Oxidized and converted to harmful substances such as ascorbic acid radicals and tocopherol radicals, which accelerates the oxidation of body hair.

[0013] Ascorbic acid and natural vitamin E, which have been added to conventional pet lotions, are generally unstable themselves and have a small amount of addition, so that their effects are not sustained.
A sufficient amount of radicals in the body hair could not be eliminated, and a sufficient effect could not be exerted. In particular, pet hair is widely present on the body surface, so it is susceptible to attack by common radical generating factors such as oxygen, light, ultraviolet rays, and other harmful chemicals that promote oxidation in various environments. With this amount, radicals could not be eliminated sufficiently and effectively.

Ascorbic acid sulfate, which is a stable ascorbic acid derivative that is not an active form, is a stable ascorbic acid derivative, but is not hydrolyzed by enzymes in dogs and cats, and is therefore not suitable for external use. It was ineffective as a radical scavenging component.

[0015]

SUMMARY OF THE INVENTION The present invention provides an external composition for improving the quality of body hair for pets by incorporating a high-concentration radical scavenging agent or a radically active radical scavenging agent which has not been conventionally added. The present inventors have found that the hair of a pet can be improved and completed the present invention. In particular, it is possible to dramatically improve the quality of pet hair by blending a high-concentration L-ascorbic acid or L-ascorbic acid-2-phosphate or the like having a high concentration of 11% by weight or more into an external composition for improving hair quality for pets. Was found.

That is, the topical composition of the present invention is sprayed, applied, stuck, and sprayed on animals having body hair or feathers such as dogs, cats and birds to supply a sufficient amount of radical scavenging components to the body hair of pets. Thus, the present inventors have found that oxidative stress can be prevented, prevented, or reduced, and that the body hair abnormality that develops by radicals can be improved, and the present invention has been completed.

The specific effects of the present invention are as follows: improvement of the deteriorated fur, improvement of the fur of the fur, prevention and prevention of split ends, improvement of the hair gloss, improvement of the deterioration of the hair color, improvement of the bleaching of the hair color, improvement of the hair loss Reduction, improvement in hair loss due to hair loss, improvement in hair strength deterioration, improvement in hair diameter reduction, reduction in color contrast of hair color, increase in hair diameter, normalization of hair cuticle Moisture retention rate is increased, and a beautiful glossy fur can be produced. Also,
For example, in the case of a dog with black and white spots, the white hair portion is whiter, the black hair is darker and glossier, the border of the hair color is clearer, and the hair color quality is improved, for example, in the case of dogs with white and black spots it can. The radical scavenging effect can also be exerted on hair-forming cells, pores, and hair roots.

[0018]

DESCRIPTION OF THE PREFERRED EMBODIMENTS The claims of the present invention consist of the following items. An external composition for improving body hair quality for pets, comprising a component selected from a high-concentration radical scavenging component or a stable active radical scavenging component or a compound thereof. 2. The pet according to claim 1, wherein the high-concentration radical scavenging component comprises a high-concentration L-ascorbic acid or a salt thereof, or the stable active radical scavenging component comprises one or a combination of stably-active ascorbic acid or a salt thereof. An external composition for improving body hair quality for pets, which comprises an external composition for improving body hair quality for pets, the auxiliary composition comprising one or a combination thereof selected from a whitening agent, an anti-inflammatory agent, a humectant, and a fungicide. 0.005 ml of the composition for external use for improving body hair quality of pet according to claim 1 or 2 per day
A method for improving the hair quality of a pet by uniformly administering to the pet's body hair, hair-forming cells and hair-forming skin tissue in 1 to 3 divided doses at a concentration in the range of 5 to 5 ml / cm2 (body surface area).

The high-concentration radical scavenging agent which can be used in the present invention may be any radical scavenging agent having a certain or more radical suppression ability when measuring the radical strength by the following method. That is, AAPH (2,2'-azobis (amidinopropane) dihydro
Hydroxy radical is generated by adding 10 mM, and the radical strength is measured by ESR. Then, if necessary, the stable active radical scavenging agent of the present invention is dissolved in an appropriate solvent so that the concentration becomes 10 mM, and then added. When measuring the suppressed radical strength, any radical scavenging agent having an ability to suppress the radical strength to 50% or less of the radical strength before adding the radical scavenging agent may be used.

Specific examples of the high-concentration radical scavenging agent that can be used in the present invention include ascorbic acid or salts thereof (hereinafter, when referred to as salts in this patent, salts having a concentration acceptable from biological safety). And specifically, sodium, potassium, calcium, magnesium, cobalt, manganese, iron, copper, ruthenium, zinc, nickel,
Aluminum, titanium, selenium, silver, vanadium, lead,
It is a simple substance selected from gallium and germanium or a composite thereof. ), Sorbic acid or salts thereof, α-tocopherol (including d-form, L-form and dl-form), retinol,
Retinoic acid, β-carotene, α-carotene, astaxanthin, retinol, retinoic acid, tretinoin,
Carotenoids such as lycopene, lutein, cryptoxanthin and optical isomers thereof, carotenoid liposome capsule, carotenoid 1,3, BG dispersion, carotenoid PG dispersion, carotenoid ethanol, carotenoid cetanol dispersion, carotenoid polyhydric alcohol dispersion Products, carotenoid alcohol dispersion, carotenoid glycerin dispersion, carotenoid jojoba oil coating,
Carotenoid vegetable oil dispersions such as carotenoid room temperature hardened oil coatings, polyphenols such as epigallocatechin, epigallocatechin gallate, epicatechin, proanthocyanidins, catechins, epigallocatechins, amino acids and protein radical scavengers, glutathione ,
Superoxydimustase, metalthionene, cysteine, cystine, catalase, SOD, ceruloplasmin, catalase, glutathione, metallothionene, thioredoxin reductase, estrogen, catecholestrogens, lignan glycosides or sesaminols or sesaminol glycosides or polyphenols Or diterpenes or theaflavins or curcumins, eucalyptus extract, iwamizukura extract, purple ground extract, rice bran extract, wheat extract, black rice extract, kidney bean extract, soybean extract, sage extract, rosemary extract, tea extract extract, fermented tea extract , Grape extract, kiwifruit extract, sesame extract, cephalatin, AsA
Liposome capsule, AsA1,3, butylene glycol (hereinafter abbreviated as BG) dispersion, AsA propylene glycol (hereinafter abbreviated as PG) dispersion, AsA ethanol, A
sA setanol dispersion, AsA polyhydric alcohol dispersion,
AsA alcohol dispersion, AsA glycerin dispersion, A
sA jojoba oil coating, AsA room temperature hardened oil coating, AsA vegetable oil dispersion, TOC, TOC liposome capsule, TOC1,3, BG dispersion, TOCPG
Dispersion, TOC ethanol, TOC ethanol dispersion,
TOC polyhydric alcohol dispersion, TOC alcohol dispersion, TOC glycerin dispersion, TOC jojoba oil coating, TOC room temperature hardened oil coating, TOC vegetable oil dispersion (the TOC may be any of dl, d, and l) ) And the like. Further, the following natural radical scavenging substances can also be used as the radical scavenging agent of the present invention. Epigallocatechin gallate, epicatechin, proanthocyanidins, catechins, succinic acid, plant-derived polyphenols, glutathione, superoxydismutase, metalthionene, kojic acid, cysteine, cystine, dipotassium glycyrrhizinate, catalase, plant seed extract, Grape seed extract, licorice extract. Liposomal capsules of natural radical scavenging products of these natural products, solvent dispersions of the natural radical scavenging products, for example, 1,3, BG dispersion, PG dispersion, ethanol dispersion, ethanol dispersion, polyvalent Alcohol dispersions, alcohol dispersions, glycerin dispersions and the like can be used. In addition, jojoba oil coatings of these natural products, room temperature hardened oil coatings, vegetable oil dispersions and the like can also be used.

The stable active radical scavenging agent of the present invention is an aqueous solution in which the radical scavenging agent is dissolved by 1% by weight when the radical scavenging agent is water-soluble or when the radical scavenging agent is an oil-soluble substance. When the almond oil solution in which 1% by weight of the radical scavenging agent is dissolved is left at 40 ° C. for one month, the radical scavenging substance has a high stability of remaining at least 50% of the radical scavenging activity measured by the following method. Any method can be used as long as the activity of the stable active radical scavenging agent is confirmed by the following method. That is, AAPH (2,
2'-azobis (amidinopropane) dihydrochloride) was added at 10 mM to generate a hydroxyl radical, and the radical strength was measured by ESR. Then, if necessary, the stable active radical scavenging agent of the present invention was added to this solution at 10 mM. When measuring the suppressed radical strength by dissolving in a suitable solvent, any stable active radical scavenging agent having the ability to suppress the radical strength to 50% or less of the radical strength before adding the stable active radical scavenging agent may be used. I just need.

Specific examples of the stable active radical scavenging agent which can be used in the present invention are L-ascorbic acid-2-esters and salts or derivatives thereof, α-tocopherol esters and salts or derivatives thereof. ,
Retinol esters and salts or derivatives thereof, retinoic acid esters and salts or derivatives thereof, and the like are given. More preferably, L-ascorbic acid-2-sodium phosphate, ascorbic acid-2-magnesium phosphate,
The following salts of ascorbic acid-2-potassium phosphate, ascorbic acid-2-phosphate (hereinafter referred to as AP), APN
a, APNa, APK, AP calcium, ascorbic acid-2-glucoside (hereinafter referred to as AG), AG-6-palmitic acid, AG-6-stearic acid, AG-6-fatty acid, AsA-2-polyglucoside, AsA- 2-diglucoside, AsA tetraisopalmitic acid, AsA-6-palmitic acid, AsA-2,6-dipalmitic acid, As
A-6-stearic acid, AsA-6-fatty acid, α-tocopherol acetate, α-tocopherol phosphate, α-tocopherol urate, α-tocopherol citrate, (the α-tocopherol may be any of dl-form, d-form and l-form Ascorbic acid-2-glucoside, ascorbic acid-2-glucosidol 6-palmitic acid, ascorbic acid-2-glucosidol 6-stearic acid, ascorbic acid-2-glucosidol 6-fatty acid, glucoside α-tocopherol, succinic α Tocopherol (the α-tocopherol may be dl-form, d-form, or l-form),
Ascorbic acid-2-polyglucoside, ascorbic acid-2-diglucoside, ascorbic acid α-tocopherol phosphate, ascorbic acid tetraisopalmitic acid, ascorbic acid-6-palmitic acid, ascorbic acid-2,6-dipalmitic acid, ascorbic acid-6 Stearic acid, ascorbic acid-6-fatty acid and all salts thereof.

The high-concentration radical scavenging agent and the stable active radical scavenging agent of the present invention include those coated with a coating agent such as gelatin and oils and fats, or those encapsulated with microcapsules, liposomes, or dextrins, Intercalated products such as diatomaceous earth can also be used.

The total concentration of the high-concentration radical scavenging agent in the present invention may be in the range of 5% to less than 90% by weight, preferably 5% to less than 90% by weight in the external composition for improving body hair quality for pets. From 11% weight to 60%
What is necessary is just the weight range. If it is less than 5%, a sufficient effect cannot be expected, and if it is less than 90%, it must be diluted and used since it causes irritation, which is complicated.

The total addition concentration of the stable active radical scavenging agent in the present invention may be in the range of 0.01 to 50% by weight in the external composition for body hair quality improvement for pets. More preferably, from 1% to 3 in terms of effect.
It may be in the range of 0% by weight. If it is less than 0.01%, a sufficient effect cannot be expected, and if it is less than 50%, it must be used after dilution since it causes irritation, which is complicated.

The following can be added as a whitening agent, an anti-inflammatory agent, a moisturizing agent, or a fungicidal agent that can be added to the composition for improving body hair quality for pets of the present invention.

The whitening agent of the present invention has a cytotoxicity of 50%.
Any component having a melanin pigment production inhibitory effect on B16 melanoma cells at a concentration of not more than% lethality may be used. Examples thereof include kojic acid or kojic acid esters and salts or derivatives thereof, arbutin and salts thereof or The derivative, hydroquinone and its salt or its derivative, chamomile extract and its salt or its derivative, ellagic acid and its salt or its derivative, placenta extract, soybean extract, glycyrrhizic acid and its salt and the like are selected. The added amount of the whitening agent in the present invention is in the range of 0.01% to 10% by weight, more preferably 0.1% to 5% by weight, in total of the simple substance or the composite.

As the humectant, a substance selected from the following may be used: polyhydric alcohols such as petrolatum, glycerin, propylene glycol, 1,3, butylene glycol, glucose, sucrose, and cellulose decomposition products. Monosaccharides and polysaccharides such as N-stearoyl phytosphingosine, ceramide, elastin, hydrolyzed elastin solution, water-soluble elastin, methylsilanol / N-acetylmethionine / hydrolyzed elastin condensate, which is a natural moisturizing factor for animal skin Silanol / hydrolyzed elastin condensate, methylsilanol / lactic acid / hydrolyzed elastin condensate, di-N-lauroyl-L-glutamate (cholesteryl, octyldodecyl), N- [2-hydroxy-3- (stearyldimethylammonio) chloride Propyl) hydrolyzed silk, Water splitting silk compounds, water-soluble silk compounds, water-soluble wheat protein inclusions, water-soluble soybean protein-containing material, water-soluble casein-containing compounds, pyrrolidone carboxylic acid N
a, dl-pyrrolidone carboxylate Na, glycyrrhizin, dipotassium glycyrrhizinate, pyrrolidone carboxylate Na, hydroxyethyl cellulose, etc., water-soluble cellulose compounds, monosaccharides, pectins, water-soluble keratin-containing substances, proleoglycans, peptidoglycans, muco polyps Certain dimethylsilanol / hyaluronic acid condensate, hyaluronic acid, dermatan sulfate, N- [2-hydroxy-3
-[3- (dihydroxymethylsilyl) propoxy] propyl] hydrolyzed collagen, myristoyl hydrolyzed collagen solution, myristoyl succinyl atelocollagen solution, coconut oil fatty acid hydrolyzed collagen, or Na thereof,
K or triethanolamine salt, oleoyl hydrolyzed collagen, taurine or its compounds, hydrolyzed collagen-alanine myristyl condensate, hydrolyzed corn protein, hydrolyzed tosaka solution, hydrolyzed potato protein, hydrolyzed porcine fibronectin, Hydrolyzed egg shell membrane, hydrolyzed egg white, hydrolyzed lanolin, casein, casein Na, succinyl atelocollagen solution, succinylated bovine serum albumin-treated sicon extract, succinyl carboxymethyl chitosan solution, succinyl chitosan, succinyl chitosan solution, water-soluble chitosans, casein Na, Hydrolyzed collagen liquids, oil-soluble collagen extract, lauric acid hydrolyzed collagen Na, lauroyl hydrolyzed collagen K, isostearoyl hydrolyzed collagen, isostearoyl hydrolyzed collagen A Roh methyl propanediol salts, undecylenoyl hydrolyzed collagen K, N-chloride [2-hydroxy-3- (stearyl dimethyl ammonio) propyl] hydrolyzed collagen, collagen,
There are elastin, lecithin, sodium polyaspartate, polyglycine, surfactin, polyglutamic acid, polyamino acid, and the like. General-purpose products include Ajinomoto Co., Inc., Eldeu, Eldew CL-202, Aquadew, Aquadew SPA-30, and the like.

The total amount of the humectant in the present invention is 1
% To 90% by weight, more preferably 3% to 50% by weight.

The anti-inflammatory anti-inflammatory agents usable in the present invention include glycyrrhizic acid and its derivatives, salicylic acid derivative-type anti-inflammatory agents, aniline derivative-type anti-inflammatory agents, antispasmodic agents, pyrazolone derivative-type anti-inflammatory agents, indomethacin-type anti-inflammatory agents, and mefenamic acid-based anti-inflammatory agents. There are anti-inflammatory agents, antihistamines, anti-allergic agents, inflammatory enzyme agents and the like. Specific examples thereof include ε-aminocaproic acid, allantoin, allantoin acetyl-DL-
Methionine, allantoin β-glycyrrhetinic acid, allantoinchlorohydroxyaluminum, allantoin dihydroxyaluminum, allantoin DL-pantothenyl alcohol, allantoin polygalacturonic acid, succinyl glycyrrhetinic acid 2Na, glycyrrhizic acid,
Tri-Na glycyrrhizinate, dipotassium glycyrrhizinate, di-Na glycyrrhizinate, monoammonium glycyrrhizinate, monoammonium α-glycyrrhizinate,
β-glycyrrhetinic acid, glyceryl glycyrrhetinate,
Stearyl glycyrrhetinate, pyridoxine glycyrrhetinate, glycyrrhetinyl stearate, lysozyme chloride, guaiazulene, ethyl guaiazulene sulfonate, sodium guaiazulene sulphonate and the like can be used. In addition, corticosteroids and their derivatives and salts thereof can also be used. For example, glucocorticoids, electrolyte corticoids (mineralcorticoids), adrenal androgens (adrenal hormones), and more specifically, glucocorticoids Contains cortisol (hydrocortisone),
Deoxycortisol and corticosterone can be used. Glucocorticoids, aldosterone, deoxycorticosterone (DOC), the 9α-fluoro compound fludrocortisone acetate (florinef), dehydroepiandrosterone (DHEA), DHEA-sulfate, and androstenedione may also be used. it can. The total amount of the anti-inflammatory agent of the present invention ranges from 0.0001% by weight to 5%.

The bactericides which can be used in the present invention include acrinol, alkylpolyaminoethylglycine, isopropanol, isopropanol / methanol denatured alcohol, ethanol, ethanol / isopropanol,
Benzalkonium chloride, benzethonium chloride, phenol water with hydrochloric acid, oxidol, potassium permanganate, cresol soap solution, chlorhexidine gluconate, sodium hypochlorite, sodium thiosulfate / geraniol modified alcohol, phenol, bronopol, formalin, povidone-iodine , Mercurochrome, iodine tincture, iodoform, iodine, resorcinol, paraben (including methyl, propyl, butylparaben), benzalkonium chloride, phenoxyethanol and the like can be used.

The amount of the fungicide of the present invention to be added is in the range of 0.0001% by weight to 5% in total of the simple substance or the composite. If the bactericide is alcohols, it can be added up to 50%.

The external composition for improving body hair quality for pets containing the high-concentration or stable active radical scavenging agent of the present invention has the following effects on the body hair of pets. That is, oxidative stress in pet hair can be prevented, prevented, and reduced by spraying, applying, sticking, and spraying the composition for external use of the present invention on animals having body hair or feathers such as dogs, cats and birds. It can ameliorate the abnormal hair growth that develops. Specific effects of the present invention include, for example, improvement of deteriorated fur, improvement of fur of fur, prevention and prevention of split ends, improvement of hair gloss, improvement of deterioration of hair color, improvement of bleaching of hair color, reduction of hair loss, hair loss Improves the decrease in the number of body hair, improves the deterioration of the strength of the body hair, improves the decrease in the diameter of the body hair, improves the contrast of the color of the hair color, improves the number of the body hair, increases the growth rate of the body hair, increases the diameter of the body hair Increase, moisture retention of body hair increases, and glossy beautiful fur can be produced. In addition, the contrast of the coat color is increased. For example, in the case of a dog with black and white spots, the white coat becomes whiter and the black coat becomes blacker and glossier, so that the quality of the coat can be improved.

In addition, hair growth cells are improved in inflammation to prevent or improve pigmentation, suppress the necrosis of hair growth cells, increase skin immunity, and enhance skin resident bacteria such as staphylococci. It prevents parasites such as viruses, fungi and ticks and eliminates radicals generated by leukocytes, thereby suppressing infectious inflammation. In addition, skin inflammation such as allergic dermatitis of pets, skin cell necrosis or skin tissue wounds caused by burns, frostbite, wounds, etc., insect bite inflammation, chemical inflammation,
It can also improve skin diseases such as chemical inflammation due to acid-alkali dermatitis.

If the above effects are to be expected from the external composition for improving body hair quality for pets containing the stable active radical scavenging agent of the present invention, the pet composition of the present invention adjusted to the above range is desired. The composition for external use for improving body hair quality is applied, sprayed, and stretched to body hair and hair-forming cells and hair-forming skin tissue in 1 to 3 times at a concentration ranging from 0.005 to 5 ml / cm2 (body surface area) per day. It is preferable to administer the medicine by attaching, spraying or the like.

The other components which can be added to the present invention are not particularly limited, but if necessary, for example, the second edition (198
4) Pharmaceutical Daily, Cosmetic Ingredients Out of Standards (1993) Pharmaceutical Daily, Japan Pharmacopoeia Act and Food Additives Official Manual, 6th Edition (1992) Hirokawa Shoten, Japan Cosmetic Industry Association (Tokyo, Japan) 2-9-14 Minato-ku Toranomon Inventive Hall 4F) All surfactants, humectants, and thickeners listed in the “List of Ingredients” published by the Committee for All Components Labeling updated on August 31, 1999 Agents, natural lipids such as squalane, oils and fats, preservatives, ultraviolet absorbers, anti-inflammatory agents such as glycyrrhizic acid, analgesics, whitening agents, chelating agents, pigments, radical scavenging agents,
Dyes, fragrances, pH adjusters, organic acids, medicinal ingredients, and other bactericides, stabilizers, preservatives, and emulsifiers usually incorporated in cosmetics can be appropriately added together in the range of 0.0001 to 90% by weight.

The form of the external composition for improving body hair quality for pets of the present invention can be in the form of spray, ointment, emulsifier, aqueous solution, emulsion, stick, gel, powder,
It can be in the form of any external preparation such as a cleaning agent, a hair dye, a bath agent, a taping agent and a patch.

[0038]

Embodiments of the present invention will be described below.

According to the following formulation, a water-soluble external preparation composition was produced by a conventional method. The figures below are expressed in weight%.

Example 1 A water-soluble external preparation of the present invention was produced according to the following formulation by a conventional method. L-ascorbic acid 20% Na polyaspartate 1% Na hyaluronate 0.01% Allantoin 0.5% Na citrate 5% Dipotassium glycyrrhizinate 0.3% Ethyl alcohol 5% Paraben 0.3% Purified water residue

Example 2 A water-soluble external preparation was prepared by a conventional method according to the following formulation. L-ascorbic acid 5% L-ascorbic acid-2-magnesium phosphate 5% L-ascorbic acid-2-glucoside 6% propylene glycol 5% Na hydroxide 0.1% xanthan gum 0.3% 1,3 butylene glycol 3 % Citric acid 1% Xanthan gum 0.3% Placenta extract 0.5% Potassium glycyrrhizinate 0.5% Water-soluble collagen 0.01% Phenoxyethanol 0.5% Purified water residue

Example 3 An emulsion was prepared according to the following formulation by a conventional method. L-ascorbic acid 11% kojic acid 1% silica-coated titanium oxide 3% silica-coated zinc oxide 3% polyaspartic acid 3% dipotassium glycyrrhizinate 0.5% avocado oil 11% behenyl alcohol 0.6% stearic acid 0.4% Glycerin fatty acid ester 0.9% Polyoxyethylene sorbitan fatty acid ester 1.1% Polyoxyethylene alkyl ether 0.4% Paraben 0.2% Fragrance 0.4% Purified water residue

Example 4 In the following examples, the names of substances and their abbreviations are abbreviated as follows. L-ascorbic acid-2-phosphate-6-malmitate sodium salt (hereinafter abbreviated as APP), L-ascorbic acid (hereinafter A)
sA), L-ascorbic acid PG dispersion (hereinafter PGAs)
A), L-ascorbic acid-2-phosphate magnesium salt (hereinafter abbreviated as APM), L-ascorbic acid-2-phosphate sodium salt (hereinafter abbreviated as APS), L-ascorbic acid-2- Sulfuric acid ester sodium salt (hereinafter abbreviated as ASS), 2-OD-glucoperidanosyl-L-ascorbic acid (hereinafter abbreviated as AG), L-ascorbic acid-2,6-dipermitate (hereinafter abbreviated as ADP), dl- TOC (DLT
The radical scavenging activity and stability were measured by the following methods, and a stable active radical scavenging agent usable in the present invention was selected. AAPH (2,2'-azobis (amidinopropane) dihydrochlorid
e) ESR by adding 10 mM to generate hydroxyl radical
When the radical strength is measured, the stable scavenging type radical scavenging agent of the present invention is added to this solution at a concentration of 10 mM by dissolving it in an appropriate solvent if necessary. A radical scavenging substance having an activity of suppressing the radical intensity to 50% or less of the radical intensity before adding the sizing agent as + as an active radical scavenging component usable in the present invention;
If not, the results are summarized in the table below. Further, the stability of the radical scavenging component usable in the present invention was evaluated by the following method. Add 1% aqueous solution of the following radical scavenger or squalane oil solution to 4
A radical scavenging component having stability in which 50% or more of the radical scavenging substance remains when left at 0 degrees for one month is designated as + as a stable radical scavenging component which can be used in the present invention, and-as a stable radical scavenging component which can be used in the present invention. The results are summarized in Table 1. As a result, only the component which became + in both tests was used as the stable active radical scavenging agent of the present invention. Although the stability test was negative, a component found to be an active radical scavenging component was taken as the high-concentration radical scavenging component of the present invention. as a result,
The stable active radical scavenging component of the present invention includes L-ascorbic acid-2-phosphate-6-palmitic acid ester sodium salt (hereinafter abbreviated as APP), L-ascorbic acid PG dispersion (hereinafter referred to as PGA)
sA), L-ascorbic acid-2-phosphate magnesium salt (hereinafter abbreviated as APM), L-ascorbic acid-2-phosphate sodium salt
(Hereinafter abbreviated as APS), 2-OD-coulcohyperanosyl-L-ascorbic acid (hereinafter abbreviated as AG), L-ascorbic acid-2,6-dipalmitate (hereinafter abbreviated as ADP), dl-TOC (hereinafter abbreviated as DLT). Abbreviated) was found to be suitable. Ascorbic acid as a high-concentration radical scavenging component of the present invention,
Sorbic acid, dl-α-tocopherol, retinol,
β-carotene, astaxanthin and epigallocatechin were found to be applicable. However, the stable active radical scavenging component and the high concentration radical scavenging component of the present invention are not limited to these.

[Table 1]

Example 5 The effect of improving the fur of pets was observed using the external composition for improving body hair quality of pets of the present invention of Examples 1 to 3. Controls 1-3, control 2-, and control 3-were obtained by removing only the radical scavenging components of Examples 1 to 3. Moreover, the control group 1-, except that the radical scavenging component and the humectant, the bactericide, the anti-inflammatory agent, and the whitening agent of Examples 1 to 3 were removed as a control group.
It was described as a control group 2-- and a control group 3--. In the experiment, dogs and cats with bad coats were collected in groups of 20 each, and a total of 120 rats were sprayed with each agent once a day at a concentration of 0.1 ml / cm2 (body surface area) once a day for 15 days. Evaluation was made based on the criterion of perfect score, and the average value is shown in the table below. Judgment is evaluated by 10 people, and the best is 10
The worst was set to 0. Table 2 summarizes the average value of 20 animals in each group evaluated by 10 persons, rounded off. From these results, the effect of the composition for external use for improving body hair quality of pets of the present invention could be confirmed.

[Table 2]

[0040]

According to the present invention, there is provided an external composition containing a high-concentration radical scavenging agent or a stable active type radical scavenging agent which has not been conventionally added to a pet body hair quality improving external composition. By spraying, applying, sticking, and spraying on animals with body hair and feathers such as dogs, cats, birds, etc., it is possible to replenish the radical scavenging component necessary and sufficient for pet hair and prevent, prevent or reduce oxidative stress It is possible to improve the abnormal hair which develops by the radicals. Specific effects of the present invention include, for example, improvement of deteriorated fur, improvement of fur of fur, prevention and prevention of split ends, improvement of hair gloss, improvement of deterioration of hair color, improvement of bleaching of hair color, reduction of hair loss, hair loss Improves the decrease in the number of body hair, improves the deterioration of the strength of the body hair, improves the decrease in the diameter of the body hair, improves the contrast of the color of the hair, improves the diameter of the body hair, normalizes the cuticle of the body hair, and retains moisture. Increases and a glossy and beautiful fur can be produced. In addition, the contrast of coat color is increased, for example, in the case of white and black spot dogs, the white part is whiter, the black part is darker and glossier, the boundary part of the coat color is clear, and the quality of the fur is improved. be able to.

Claims (3)

[Claims] An external composition for improving the hair quality of a pet, comprising a component selected from a high-concentration radical scavenging component or a stable active radical scavenging component or a compound thereof. 2. The high-concentration radical scavenging component comprises a high-concentration L-ascorbic acid or a salt thereof, or the stable active radical scavenging component comprises one or a combination of a stable active ascorbic acid or a salt thereof. The pet hair quality improving external composition for pets, wherein the pet hair quality improving external composition for pets according to claim 1 further comprises a sub-component comprising one or a compound selected from a whitening agent, an anti-inflammatory agent, a humectant, or a fungicide. Composition. 3. The composition according to claim 1, wherein the composition for external use for improving body hair quality of pets is 0.005 ml / cm 2 to 5 ml / cm 2 per day.
(Body surface area) A method for improving the body hair quality of a pet by uniformly administering to the body hair, hair-forming cells, and hair-forming skin tissue of the pet in 1 to 3 divided doses within the range of (body surface area).