JP2001354522A - Hair tonic containing ascorbic acid derivative - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a hair tonic comprising an L-ascorbic acid derivative exhibiting excellent effects on hair restoration, hair growth, hair growth promotion and hair nutrition, not showing harmful side effects such as skin irritation, etc. SOLUTION: This hair tonic contains an L-ascorbic acid derivative.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to a novel hair restorer.

[0002]

2. Description of the Related Art In general, hair restorers, hair growth agents, hair growth promoters,
Since a hair restorer called a hair restorer or the like is used continuously for a relatively long period of time, it is required to have excellent hair growth, hair growth, promotion of hair growth, hair growth effect, and high safety.
Further, it is more desirable that the components used are stable against air, heat, and the like. However, none of the conventionally known components has such a satisfactory effect.

Some of the L-ascorbic acid derivatives have already been incorporated into pharmaceuticals, foods, cosmetics, etc. for the purpose of stabilizing agents, antioxidants, etc., but the L-ascorbic acid derivatives have an effect on hair growth. There are no reports of involvement.

[0004]

SUMMARY OF THE INVENTION The object of the present invention is to
A new hair restorer is provided.

[0005]

The present inventors have newly found that an L-ascorbic acid derivative is useful as a component capable of solving the above-mentioned problems, and completed the present invention.

[0006] That is, the present invention relates to a hair restorer containing an L-ascorbic acid derivative and a hair composition containing the L-ascorbic acid derivative as a hair restorer.

BEST MODE FOR CARRYING OUT THE INVENTION

Hereinafter, the present invention will be described. The hair restorer in the present invention means any of a hair restorer, a hair growth, a hair growth-promoting, and a hair-growth, or a combination of two or more of these. should not be done.

[0008] L-ascorbic acid is widely used as a water-soluble antioxidant vitamin (generally also referred to as vitamin C) having strong reducing properties in medicines, foods, cosmetics, etc., but has the highest stability among water-soluble vitamins. It is low, easily oxidized by oxygen in the atmosphere, is weak to heat, and has particularly low stability when a trace amount of metal such as copper is present. Furthermore, since this is water-soluble, it is difficult to mix it with a lipophilic one. In recent years, these problems have been improved by using alkali (earth) metal salts such as sodium salts and calcium salts of L-ascorbic acid, and esters of L-ascorbic acid with fatty acids, phosphoric acid, and sulfuric acid. is there. The present invention relates to those L
-It relates to a hair restorer containing an ascorbic acid derivative.

Hereinafter, the L-ascorbic acid derivative according to the present invention will be described in detail. Specific examples of the L-ascorbic acid derivative in the present invention include L-ascorbic acid fatty acid ester, L-ascorbic acid phosphate, L-ascorbic acid sulfate and salts thereof.

In the present invention, L-ascorbic acid fatty acid ester is preferable as the L-ascorbic acid derivative, and L-ascorbic acid fatty acid ester is preferably an ester of L-ascorbic acid and a medium-chain or long-chain fatty acid. Examples of the medium-chain fatty acid include a saturated or unsaturated fatty acid having 6 to 13 carbon atoms, and specifically, caproic acid, enanthic acid, caprylic acid, pelargonic acid, capric acid, undecylic acid, undecylenic acid, Lauric acid and the like can be mentioned. As long-chain fatty acids,
Examples thereof include a saturated or unsaturated fatty acid having 14 to 22 carbon atoms, and specifically, myristic acid, pentadecanoic acid, palmitic acid, palmitoleic acid, margaric acid,
Stearic acid, oleic acid, linoleic acid, linolenic acid,
Nonadecanoic acid, arachiic acid, eicosenoic acid, arachidonic acid, behenic acid and the like can be mentioned. The ester of L-ascorbic acid and a fatty acid is formed by one or more hydroxyl groups of L-ascorbic acid and an ester bond of the fatty acid. When a plurality of hydroxyl groups are ester-bonded to the fatty acid, the fatty acids are the same. Or a different one.

Examples of the L-ascorbic acid fatty acid ester in the present invention include L-ascorbic acid myristate, L-ascorbic acid palmitate, L-ascorbic acid stearate, L-ascorbic acid dipalmitate, L-ascorbic acid distearate and the like. be able to. Among them, L-ascorbic acid-6-palmitate, L-ascorbic acid-6-stearate and L-ascorbic acid-2,6-dipalmitate can be mentioned as particularly preferred.

Examples of the L-ascorbic acid phosphate include L-ascorbic acid-2-phosphate, L-ascorbic acid-3-phosphate and the like. Examples of the L-ascorbic acid sulfate include: L-ascorbic acid-2-sulfate, L-ascorbic acid-
3-sulfate ester and the like can be mentioned.

L-ascorbic acid fatty acid ester, L-ascorbic acid phosphate ester, and L-ascorbic acid sulfate ester may form a salt, and the salt may be an alkali metal salt such as a sodium salt or a potassium salt, or a calcium salt. And alkaline earth metal salts such as magnesium salts.

These L-ascorbic acid derivatives can be obtained by a known synthetic technique. A commercially available L-ascorbic acid derivative can also be used.

The hair restorer and the composition for hair of the present invention can be administered orally or parenterally, but preparations which can be administered parenterally and directly to the hair scalp are preferred. An external preparation can be mentioned as a form. Specifically, as the dosage form of the oral administration preparation, tablets, powders,
Capsules, granules, oral liquids and the like can be mentioned, and examples of dosage forms of parenteral administration preparations include external preparations such as lotions and aerosols, and injections. Also, shampoo, rinse, conditioner,
You may mix | blend with a hair tonic, a hair cream, a hair liquid, etc. In the present invention, an external preparation is preferable as a dosage form.

The preparation can be carried out by a known preparation technique, and an appropriate preparation additive can be added to the preparation. Pharmaceutical additives include excipients, suspending agents, emulsifiers,
Preservatives, humectants, fragrances and the like can be mentioned. In addition,
The formulation additives to be added in the formulation, in the dosage of the formulation,
It is necessary to be harmless to the living body such as the human body, and not to hinder the effect of the active ingredient in the preparation.

The formulated hair restorer of the present invention, that is, the composition for hair, is used in an appropriate amount depending on the sex, age, symptoms, etc. of the user, in a site where hair is reduced and / or a site where hair is generated. May be applied or sprayed. In the formulation
The amount of the L-ascorbic acid derivative may be appropriately determined in consideration of the sex, age, symptoms, purpose of use, etc. of the user, but is preferably in the range of 0.001 to 10% by weight,
More preferably, it is in the range of 1 to 5% by weight.

Further, to the hair restorer and the composition for hair of the present invention, a known component having a hair growth, hair growth, hair growth promotion and hair growth effect may be further added. As these components, for example, goshuyu, gomiko, peony skin, cucumber, white moss bark, gokahi, midsummer, rhubarb, beef knee, guikoko, bukuryo, dried ginger,
Chen skin, licorice, hundred parts, bone skin, Saiko, Tenma, Hakushoku, thorn,
Keishi, ginseng, narcissus wisteria, bone crushing, pepper, yellow ream, ginseng, black bean, koshu, ginseng, bamboo ginseng, osseous fat, toki, chicken blood wisteria, dansin, safflower, peach, windbreak, Akane Kusane, Kensan, Sanshuyu,
Herbal medicines such as semi-lily, Yangmei skin, side bamboo leaf and this medicine, and extracts of these crude drugs (tinctures, extracts, etc.), furthermore, carpronium chloride, pantothenyl ethyl ether, minoxidil, cepharanthin, benzyl nicotinate, nicotinamide, Biotin, D-pantothenyl alcohol, isopropylmethylfinol, hinokitiol,
L-menthol, soluble cystine, octopirox, benzalkonium chloride, pyridoxine and its derivatives,
Salicylic acid, diphenhydramine hydrochloride, glycyrrhizic acid, glycyrrhetinic acid, glyceride pentadecanoate and the like can be mentioned. These components may be added alone to the hair restorer and the hair composition of the present invention, or may be added in combination of two or more.

The hair restorer and the composition for hair of the present invention are specifically used for hair growth, hair growth, promotion of hair growth and / or hair growth. Therefore, the effects and effects of the hair restorer and the hair composition of the present invention include hair growth, hair growth, thinning hair, promotion of hair growth, promotion of hair growth, prevention of hair loss (hair loss), hair loss after disease and postpartum, hair growth, Alopecia areata, hair loss deficiency, pityriasis alopecia, seborrheic alopecia, diffuse alopecia, young baldness (mature alopecia), and elderly baldness can be mentioned.

[0020]

The L-ascorbic acid derivative according to the present invention has excellent hair growth, hair growth, promotion of hair growth and hair growth.
It did not show any harmful side effects such as skin irritation. Therefore, the L-ascorbic acid derivative is useful as a component of a hair restorer.

[0021]

EXAMPLES The present invention will be described in more detail with reference to the following Examples, which by no means limit the present invention. [Example 1] Hair growth test using C3H mice Six-week-old C3H / He male mice were preliminarily reared for one week and then used in experiments. That is, a 7-week-old C3H / He male mouse with a resting hair cycle was cut with a hair clipper in a range of about 4 to 5 cm ² of the back coat, and further cut with an electric shaver until the skin was completely visible. . On the day after cutting, select mice without scars and hair residue, and
Each animal was divided into groups.
Was applied evenly five times a week, and the hair growth effect was evaluated. As an index of the hair-growth effect, the change in skin color of the cut hair part is measured using a colorimeter (Minolta “Color-colorimeter CR-300: Measurement diameter 22 mm”) to measure the L value, and the change in skin color over time (ΔL) is measured. It was calculated by the following equation.

ΔL = L value at start−L value at measurement

Further, changes (such as presence or absence of inflammation) of the shaved area to which the test solution was applied were visually observed. The test solution was
It was prepared by dissolving L-ascorbic acid-6-palmitate in 100% ethanol to a predetermined concentration. The results are shown in FIG.

As a result, L-ascorbic acid-6-palmitate promoted mouse hair growth in a concentration-dependent manner. In addition, no harmful changes such as inflammation were observed on the skin at the site of application.

[Brief description of the drawings]

FIG. 1 is a graph showing the results of Example 1.

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Claims (7)

[Claims] 1. A hair restorer containing an L-ascorbic acid derivative. 2. The L-ascorbic acid derivative is one or more selected from the group consisting of L-ascorbic acid fatty acid ester, L-ascorbic acid phosphate ester and L-ascorbic acid sulfate ester. Item 10. The hair restorer according to Item 1. 3. A hair restorer containing L-ascorbic acid fatty acid ester. 4. The method according to claim 1, wherein the L-ascorbic acid fatty acid ester is L-ascorbic acid.
The hair restorer according to claim 3, which is an ester of ascorbic acid with a medium-chain or long-chain fatty acid. 5. The method according to claim 5, wherein the L-ascorbic acid fatty acid ester is L-ascorbic acid.
-Ascorbic acid palmitate, L-ascorbic acid stearate, L-ascorbic acid dipalmitate and L
The hair restorer according to claim 3 or 4, which is one or more kinds selected from the group consisting of ascorbic acid distearate. 6. A hair composition containing an L-ascorbic acid derivative as a hair growth component. 7. The hair composition according to claim 6, wherein the dosage form is an external preparation.