JP2001240541A - Extermination method and exterminator for animal ectoparasites - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an extermination method for ectoparasites (ixodids or the like) in domestic animal and pet or the like which has generalized and sustained effects by means of a convenient oral administration or the like. SOLUTION: The extermination method and exterminator for animal ectoparasites are characterized by administering a drug having 2-(2,6- difluorophenyl)-4-(2-ethoxy-4-tertiary-butylphenyl)-2-oxazoline as an active ingredient to host animals and exterminating ectoparasites via blood of them.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a method for controlling ectoparasites, particularly ticks, and a pesticide therefor.

[0002]

2. Description of the Related Art As a means for controlling ticks ectoparasitic to livestock, pets and the like, a so-called non-systemic administration method in which a liquid preparation is applied to the skin of an animal is generally used. However, such a method, except for the processing unit, especially in the portion far from the processing unit, the effect is slow,
In addition, the effect was not always satisfactory in terms of immediate effect and residual effect, for example, the effect was lowered or the effect was unstable due to washing with a water bath, body hair, body surface, and the like.

[0003]

Under these circumstances, the present inventors have conducted intensive studies and as a result, have found that 2- (2,6-difluorophenyl) -4- (2-ethoxy-4-tert-butylphenyl). It has been found that by administering -2-oxazoline, ticks can be effectively controlled from the whole body of an animal via blood, and the present invention has been completed. That is, the present invention relates to a method for administering a host animal, comprising administering 2- (2,6-difluorophenyl) -4- (2-ethoxy-4-tert-butylphenyl) -2-oxazoline to the host animal. It is intended to provide a method for controlling ectoparasites from the whole body of the host animal via blood and a parasiticidal agent therefor.

[0004]

DESCRIPTION OF THE PREFERRED EMBODIMENTS 2- (2,6) used in the present invention
-Difluorophenyl) -4- (2-ethoxy-4-tert-butylphenyl) -2-oxazoline (generic name: ethoxazole) is a compound known to have a controlling effect on various mites. Until now, however, it has been used exclusively in the treatment area, and it is completely known that it can be effectively eliminated from the whole body of animals through blood by administering it as an oral preparation, transdermal preparation, injection, etc. Not been.

2- (2,6-difluorophenyl) -4
-(2-ethoxy-4-tert-butylphenyl)
2-Oxazoline (hereinafter, referred to as the present compound) can be produced according to the method described in JP-A-4-508705. The oral dose of the present compound is 1k body weight of the host animal.
Per g, usually 0.01 mg to 1000 mg, preferably 0.1 mg
mg to 100 mg.

[0006] The method of administration to a host animal is an administration method in which the present compound is finally transferred to the blood of the animal. For example, oral administration, parenteral administration, administration by transplantation and the like can be mentioned.

[0007] Oral administration includes, for example, a method in which the animal is fed with a feed in which the present compound is previously mixed, and a method in which the compound is administered as an easy-to-drink animal such as biscuits, wafers, tablets, liquids, and capsules.

Suitable carriers in these dosage forms include lactose, sucrose, saccharides such as mannitol, sorbitol, cellulose and derivatives thereof, and excipients such as calcium phosphate;
Starch paste using starch of corn, wheat, rice, potato, binder such as gelatin, tragacanth, methylcellulose, agar, alginic acid, alginate; lubricant such as silica, talc, stearic acid, stearic acid salt; gum arabic, talc Saccharide cores composed of saccharide solutions containing, for example, polyvinylpyrrolidone, polyethylene glycol, titanium dioxide and the like. It is also possible to appropriately add a coloring agent and a seasoning.

As an orally administrable agent, for example, a mixture comprising the present compound, an excipient such as lactose, a binder such as starch, a lubricant such as talc and magnesium stearate, a stabilizer and the like, is dried capsules made of gelatin. Or a mixture obtained by dissolving or suspending the present compound in an appropriate liquid, for example, fatty oil, paraffin oil, or liquid polyethylene glycol, and adding a stabilizer as necessary. Glycerol, sorbitol, etc.).

[0010] Parenteral administration includes, for example, transdermal administration using a transdermal absorbent, subcutaneous administration using an injection for subcutaneous injection, intramuscular administration using an injection for intramuscular injection, and injection for intravenous injection. Methods include intravenous administration, anal administration using suppositories, and the like.

For transdermal administration and injection administration, solutions, suspensions and emulsions of the compounds are employed. As the solvent, water, physiological saline, aqueous solvents such as Ringer's solution, fatty oil,
Examples include lipophilic solvents such as sesame oil, corn oil, and synthetic fatty acid esters. In the case of an aqueous solution using an aqueous solvent, a water-soluble salt of the present compound is usually used. For suppositories, oleaginous bases such as cacao butter, lauryl butter, hardened oils, semi-synthetic bases (Witepsol, Suppocire, Pharmasol, etc.), or macrogol bases, glycerogelatin bases, gel bases (mainly And water-soluble base such as methyl cellulose and sodium carboxymethylcellulose) and mixed with the present compound.

[0012] Another example is a method in which a preparation in which the present compound is applied or kneaded on a resin piece or the like is transplanted into a host animal.

In the control method of the present invention, in addition to the present compound, other generally known insecticidal components can be added. As other insecticidal components, for example, pyriproxyfen, methoprene, hydroprene, rufenuron, chlorfluazuron, flufenoxuron,
Insect growth regulators such as hexaflumuron, diflubenzuron, cyromazine and tebufenozoid; insecticides such as N-phenylpyrazole compounds; animal endoparasiticides such as milbemycin, abamectin, ivermectin and the like.

The ectoparasites controlled by the control method of the present invention include Haemaphyxa, which is an ectoparasite of livestock such as cattle and sheep and pets such as dogs and cats.
lislongicornis), Haemaphysalis ja
ponica), Boophilus microplus, Dermacentor recticulatus, Dermacentor taiwanensis, Haemaphysalis flava, Ixodes ov
atus), acarid pests such as Ixodes persulcatus, house fly (Musca hervei), house fly (Musca bezzii), and fly fly (Haematobia irritan)
s), Simulium iwatens, Culicoides oxystoma, Tabbyus (Tabanus chrysur)
us), Culex pipiens, Aedes albopictus and other dipteran pests, lice
ematopinus eurysternus, sheep lice (Damalinia)
ovis) and lice of the louse, Cat flea (Ctenocephalides)
felis), fleas such as dog flea (Ctenocephalides canis), and flea insects (Xenopsylla cheopis).

The target animals include livestock and pets, such as cattle, sheep, horses, goats, and other livestock.
Pets include, for example, rodents such as mice, rats, hamsters and squirrels, lagomorphs such as rabbits, carnivores such as dogs, cats and ferrets, and birds such as ducks, chickens and pigeons.

[0016]

Next, the present invention will be described in more detail with reference to Formulation Examples and Test Examples. Formulation Example 1 2- (2,6-difluorophenyl) -4- (2-ethoxy-4-tert-butylphenyl) -2-oxazoline (hereinafter referred to as compound A) 30 mg, dextrin 70 g, potato starch 20 g, 6g powdered animal feed (made by Oriental Yeast, CE-2), sesame oil 2
g and 2 g of water are mixed and kneaded, 1 g of the obtained powder is put in a mold, and a pressure of about 8 tons is applied to obtain a tablet.

Formulation Example 2 0.2 g of Compound A is dissolved in glycerol formal to make a total volume of 100 ml to obtain a liquid preparation for injection.

Test Example 1 50 adult mites of Haemaphyxalis longicornis were infested on the body surface of a beagle dog (live weight 12 kg). Compound A (360 mg) was added to 30 g of dog food (Science Diet Maintenance: Hills),
After mixing, the whole amount was taken orally (corresponding to 30 mg / kg administration). Thereafter, Haemaphysalis longicornis, which had fallen from dogs after blood feeding, were collected, bred individually in test tubes and spawned. 100 laying eggs are placed in a test tube, and the
They were stored in a thermostat at 2 ° C. and a relative humidity of 90% or more, and the number of hatchings was examined one month later. In addition, the number of hatching eggs was also examined in the same manner as for the laying eggs obtained from the tick, Haemaphysalis longicornis, which were infested with the drug-free group. As a result, the hatching inhibition was 10% or less in the drug non-administration group, whereas the hatching inhibition was 80% or more in the drug administration group.

[0019]

According to the present invention, ticks ectoparasitic to livestock, pets, etc. can be systemically ectoparasiticized through the blood of the host animal by administration of simple oral, transdermal and injection preparations. Insects can be controlled.

Claims (5)

[Claims] 1. 2- (2,6-difluorophenyl)-
An animal characterized in that a drug containing 4- (2-ethoxy-4-tert-butylphenyl) -2-oxazoline as an active ingredient is administered to a host animal, and ectoparasites are eliminated through the blood of the host animal. How to control ectoparasites. 2. 2- (2,6-difluorophenyl)-
The dose of 4- (2-ethoxy-4-tert-butylphenyl) -2-oxazoline was determined to be
The method according to claim 1, wherein the amount is 0.1 to 100 mg / kg. 3. The ectoparasiticide according to claim 1 or 2, wherein the administration is carried out by oral administration, transdermal absorption, subcutaneous administration, intramuscular administration, intravenous administration or suppository. . 4. 2- (2,6-difluorophenyl)-
An ectoparasite-controlling agent for controlling ectoparasites via blood of a host animal, comprising 4- (2-ethoxy-4-tert-butylphenyl) -2-oxazoline as an active ingredient. 5. An oral administration agent, a transdermal absorption agent, a subcutaneous administration agent,
5. An intramuscular administration, an intravenous administration, or a suppository.
The ectoparasiticide as described.