JP2001159635A - Sample processing system - Google Patents

Abstract

(57) [Summary] [PROBLEMS] To efficiently create a primary mixed sample and a secondary mixed sample. An original sample after blood collection is supplied to a receiving device, and an unsuitable sample is extracted in the receiving device. Thereafter, the original sample is introduced into any one of the basic systems 42 by the transport system. This basic system 42
In, one primary mixed sample is created from m original samples, and one secondary mixed sample is created from n primary mixed samples. Each sample is managed by a barcode label, and a table 51 representing the correspondence between each sample is created in the storage device 50. When the secondary mixed sample is determined to be positive, the corresponding primary mixed sample and original sample are specified with reference to the table 51. The dispensing unit has a function of dispensing a dummy sample.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a sample processing system, and more particularly to a system for automatically preparing a primary mixed sample and a secondary mixed sample from an original sample.

[0002]

2. Description of the Related Art A blood test center performs various tests on blood samples (original samples) sent from blood collection centers in various places. The number of samples per day inspected by an inspection center reaches, for example, 10,000, and there is a strong demand for rationalization and efficiency of the inspection. Note that some serologic tests are also performed as primary screening at the blood collection center, but a wider range and higher accuracy are performed at the test center.

In recent years, nucleic acid amplification tests (NAT: Nucleic
acid amplification test) has been put into practical use, and high-sensitivity blood tests can be performed. However, the cost per inspection is relatively high, and the process is complicated, so that the number of NAT inspections per day cannot be increased so much at present.

[0004] Therefore, a technique of inspecting a large number of specimens at once is used. Specifically, first, a primary mixed sample (primary pool sample) is created by combining, for example, 50 original samples into one, and then, for example, 10 primary mixed samples are collected into one.
A secondary mixed sample (secondary pool sample) is created. The primary mixed sample and the secondary mixed sample are stored for a certain period. In parallel with the storage, a test by the NAT method is performed on the secondary mixed sample. If the result of the test is positive, a test by the NAT method is performed on a plurality of primary samples used in preparing a secondary sample as the positive sample, and further, it is determined to be positive thereby. Inspection by the NAT method is performed on a plurality of original samples used when creating the primary mixed sample. Thereby, a positive original sample is specified. Note that various methods have been proposed for tracking a positive original sample.

[0005] Usually, the probability of occurrence of a positive sample is extremely low. Therefore, according to the above-described batch test of a mixed sample, a positive sample can be reliably determined while improving the test efficiency.

[0006]

However, conventionally, a large amount of manual work was required to prepare a mixed sample by the above-mentioned pretreatment, and efficient processing was difficult. Therefore, there is a demand for an automated system that efficiently performs a series of steps from the reception of an original sample to the creation of a secondary mixed sample, while taking into account the specific circumstances of the mixed sample.

The present invention has been made in view of the above-mentioned conventional problems, and has as its object to provide a sample processing system having a high processing capability.

Another object of the present invention is to provide a sample processing system which can flexibly cope with an increase or decrease in the number of samples.

[0009]

Means for Solving the Problems (1) In order to achieve the above object, the present invention provides a primary dispensing method in which a fixed amount is collected from m original samples and mixed to prepare a primary mixed sample. Means, a predetermined amount of each sample from the n primary mixed samples, and a secondary dispensing means for mixing them to create a secondary mixed sample, and a correspondence relationship between the original sample, the primary mixed sample, and the secondary mixed sample. A storage unit for storing, and a tracking unit for specifying the primary mixed sample and the original sample corresponding to the positive sample by referring to the correspondence when any of the secondary mixed samples is designated as a positive sample; and , Is included.

According to the present invention, as shown in FIG. 1A, first, a predetermined amount is collected from m original samples 30 by primary dispensing means, and is mixed as one primary mixed sample 32. Is done. Here, for example, the original sample is a blood sample that has been centrifuged after collection. As shown in (B), when n primary mixed samples are created by the above processing,
A predetermined amount of each primary mixed sample is collected by the secondary dispensing means and mixed as one secondary mixed sample 34 (see (C)). Here, the primary dispensing means and the secondary dispensing means may be the same dispensing device, but if they are configured as separate dispensing devices, efficient dispensing can be realized.
As shown in (D), a predetermined test is performed on the secondary mixed sample, and if the test result is positive, the tracking means detects the primary mixed sample and the original sample corresponding to the secondary mixed sample. Is easily identifiable. Then, the positive original sample is determined using various methods.

According to the present invention, the operation of preparing the primary mixed sample and the secondary mixed sample can be automated, and the positive samples can be efficiently tracked according to the stored correspondence between the samples. The parameter m is, for example, 50, and the parameter n is 10. Under this condition, the secondary mixed sample is a sample obtained by mixing 500 samples.

Preferably, the original sample, the primary mixed sample, and the secondary mixed sample are managed by a label including sample identification information, and the sample identification information of each sample is registered in the storage unit. According to this label management, individual management of each sample can be reliably performed. Label readers and label applicators will be provided where necessary on the system.

Preferably, the apparatus further includes mixing number setting means for variably setting the parameters m and n, wherein the primary dispensing means and the secondary dispensing means operate according to the mixing number condition set by the mixing number setting means. I do. According to this configuration, an appropriate mixing ratio, the number of mixing, and the like can be freely set according to the inspection conditions, and automatic dispensing is performed according to the settings.

Preferably, a dummy sample holding means for holding a dummy sample, and a fraction processing for executing the dispensing of the dummy sample by the shortage when the number of samples is insufficient when n primary mixed samples are created. Means. According to this configuration, when a secondary mixed sample is sequentially created in units of m × n original samples for a large number of original sample groups, the last remaining original sample count is m × n Even if the number is less than the number, it is possible to create a predetermined amount of the secondary sample by supplementing the shortage with the dummy sample. Here, as the dummy sample, a liquid (physiological saline or the like) that does not hinder the test is used. This replenishment of the dummy sample is performed at least at the time of creating the primary mixed sample and at the time of creating the secondary mixed sample.

Preferably, dummy sample holding means for holding a dummy sample, and suction abnormality handling means for executing dispensing of the dummy sample instead of the sample according to a predetermined condition when a sample suction abnormality is detected. ,including. According to this configuration, when a dispensing abnormality occurs, the substitute dispensing of the dummy sample can be performed to maintain a predetermined mixing ratio or a predetermined mixing amount. Therefore, it is possible to individually deal with the dispensing abnormality without obstructing the flow of the entire system, and prevent a decrease in work efficiency.

(2) In order to achieve the above object, the present invention provides a sample processing system including at least one sample processing station, wherein the sample processing station comprises:
An opening device that opens the original sample, a primary dispensing device that collects a fixed amount from the m original samples after opening and mixes them to create a primary mixed sample, and n primary mixing devices It includes a secondary dispensing device that collects a predetermined amount of each sample from the sample and mixes them to create a secondary mixed sample, and a stopper device that closes each of the samples.

According to the above arrangement, in preparing the primary mixed sample and the secondary mixed sample, the stopper of the original sample (blood collection tube) is automatically removed, and after dispensing, the stopper is attached to each sample (test tube). Thus, subsequent storage can be facilitated. As described above, a series of flows is automated, and the number of processes per day can be significantly improved as compared with the related art.

Preferably, the sample processing station includes a centrifugal separator for performing a centrifugal separation process on the original sample prior to the opening in order to prevent the droplets from scattering at the time of opening. The sample may be attached to the back of the stopper or the like due to the influence of transportation or transportation. In this case, if the stopper is opened unintentionally, the sample may be scattered and contamination may occur. In contrast, if centrifugation is performed before opening,
The sample attached to the back of the stopper can be shaken off to prevent contamination.

Preferably, the plugging device includes a handling unit for holding the stopper, and a robot mechanism for three-dimensionally transporting the handling unit. If the handling unit is configured to be three-dimensionally movable in this manner, the degree of freedom in positioning the original sample, the primary mixed sample, and the secondary mixed sample can be increased.

Preferably, the apparatus further includes a sample extracting apparatus for executing an adequacy test on each of the original samples prior to introducing the original samples into the sample processing station and extracting an unsuitable sample. According to this configuration, for example, a sample for which a positive test result has already been obtained in a preliminary test, a sample having a management problem, and the like can be excluded from processing targets.

(3) In order to achieve the above object, the present invention provides a plurality of sample processing stations capable of operating in parallel with each other, an original sample supply device for distributing an original sample to the plurality of sample processing stations, An operation management device that performs operation management of the sample processing station, wherein each of the sample processing stations includes an opening device that opens the original sample and an m number of the original samples after opening. A primary dispensing device that collects a certain amount at a time and mixes them to create a primary mixed sample, and a secondary dispensing device that collects a fixed amount from n primary mixed samples and mixes them to create a secondary mixed sample It is characterized by including a dispensing device and a stopper device for closing each of the above specimens.

According to the above configuration, there is an advantage that the sample processing stations having the same function are installed in parallel, and the number of operating sample processing stations can be appropriately adjusted according to processing conditions such as the number of processed samples. Further, even if a trouble occurs in one sample processing station, the sample processing can be advanced using another sample processing station.

[0023]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Preferred embodiments of the present invention will be described below with reference to the drawings.

FIG. 2 conceptually shows each processing in the test center 12 in which the sample processing system according to the present invention is installed. In FIG. 2, the original sample group transported from the blood collection centers 10 in various places is
2 (see reference numeral 14), and then an unsuitable sample is extracted from the original sample group (reference numeral 1).
6). Here, the unnecessary sample to be extracted is
For example, a positive sample determined to be positive in the pre-test at the blood collection center 10, a reserved sample for which the judgment was suspended in the pre-test, an information-unregistered sample to which no sample information is added, and a bar code assigned to each sample. An unreadable sample that could not be read, and the like. As described above, since the unsuitable sample is extracted prior to the creation of the primary mixed sample and the secondary mixed sample, there is an advantage that unnecessary sample processing can be eliminated and processing efficiency can be improved. Incidentally, the result of the pre-test at the blood collection center 10 is, for example, FD
The electronic information is sent to the inspection center 12 as electronic information stored in the storage device or the like or electronic information transmitted online.

After the extraction of the unsuitable sample, a primary mixed sample is prepared as indicated by reference numeral 18. As described with reference to FIG. 1, for example, one primary mixed sample is created from m original samples, and by repeating this, n primary mixed samples are created. Then, as indicated by reference numeral 20, one secondary mixed sample is created from the n primary mixed samples. Here, if m is 50 and n is 10, the secondary mixed sample corresponds to a sample obtained by mixing 500 original samples.
Incidentally, the primary mixed sample preparation step and the secondary mixed sample preparation step indicated by reference numerals 18 and 20 are executed by using an automatic dispensing device described later.

The above-described steps are repeatedly executed, and the inspection based on the above-described NAT method is executed as indicated by reference numeral 24 on the secondary mixed specimens sequentially prepared. Incidentally, the original sample, the primary mixed sample, and the secondary mixed sample are respectively stored and prepared for later tracking (see reference numeral 22). Of course, the correspondence of each sample is managed electronically,
Specifically, the correspondence is managed by a sample correspondence table.

If the secondary mixed sample is determined to be negative by the test based on the NAT method, the negative is found uniformly for, for example, 500 original samples from which the secondary mixed sample is based. On the other hand, if the secondary mixed sample is determined to be positive, for example, any of the original samples in the 500 samples is considered to be a positive sample. Therefore, as indicated by reference numeral 26, a positive sample tracking process is executed according to the above-described correspondence between the samples.

In this case, for example, first, a retest is performed for each of the n primary mixed samples corresponding to the secondary mixed sample, and if a positive sample is present among them, The m original samples constituting a certain primary mixed sample are identified, and a positive original sample is finally identified from them. Incidentally, various methods can be adopted for this tracking method. In any case, when such tracking is performed, the correspondence between samples is referred to.

In FIG. 2, reference numerals 100 and 102
All or some of the functions indicated by are realized by the sample processing system according to the present embodiment. In the tracking indicated by reference numeral 26, the re-inspection itself is performed by an inspection device that executes the inspection process indicated by reference numeral 24. Of course, it is also possible to integrate both such a test apparatus and a sample processing system to form an integrated test system.

Next, a preferred embodiment of the sample processing system according to the present embodiment will be described with reference to FIG. This sample processing system is a preprocessing system that creates a primary mixed sample and a secondary mixed sample from a plurality of original samples prior to a sample test.

In FIG. 3, the sample processing system is roughly divided into a system controller 36, a receiving device 38, a transport system 40, and a plurality of basic systems 42. The system controller 36 is constituted by, for example, a computer machine, and data of a pre-inspection result is input to the system controller 36 via a recording medium or a network. Further, data of a NAT inspection result is input from an inspection device (not shown) via a recording medium or a network. The pre-inspection result is used in a sampling process in the reception device 38 described later, and the NAT inspection result is used as a precondition for performing the tracking shown in FIG.

The system controller 36 has a display 46
And the input unit 48 are connected. The display unit 46 is a display, and the display unit 46 displays various information such as the operation status of the present system. The input unit 48 includes various user interfaces such as a keyboard and a mouse, and specifies the number of basic systems 42 actually operated via the input unit 48, and specifies the number of original samples to be supplied to each basic system 42. It can be performed. That is, the system according to the present embodiment includes a plurality of basic systems 42 connected in parallel in order to realize the most efficient preprocessing according to the variation in the number of samples transported to the test center in large quantities. It is possible to operate only an arbitrary number of basic systems 42 among the plurality of basic systems 42. For example, it is possible to operate all the basic systems 42 in the normal state, and to operate only a part of the basic systems 42 at the end of the preprocessing. Further, even if a trouble occurs in a part of the basic system 42, there is an advantage that the other basic system 42 can be operated to prevent the whole system from going down.

The system controller 36 has a storage device 5
0 is connected. The storage device 50 is a device such as a RAM or a hard disk.
At the top is stored a sample correspondence table 51 to be described later with reference to the drawings. In tracking the positive sample, the sample correspondence table 51 is referred to.

The original sample group that has arrived is input to the receiving device 38, and the check is performed for each sample. Specifically, a sample extraction process as indicated by reference numeral 16 in FIG. 2 is executed. That is, the barcode label attached to the original sample (blood collection tube) is read, and an unsuitable sample such as a positive sample or a determination pending sample is automatically extracted according to the contents and the pre-test result, and the primary mixed sample and the secondary sample are collected. Only the original sample suitable for preparing the next mixed sample will be discharged. Incidentally, the extraction of the sample is performed on a sample basis or on a rack basis. The original sample that has undergone predetermined processing by the receiving device 38 is mounted on a loading device 52 in the transport system 40 in rack units.

The loading device 52 has two mounting tables, and an original sample rack is set on each table. Then, the racks are sequentially flown from those two tables to the transport line 54, and the racks are transported from the transport line 54 to the respective basic systems 42. Here, such transport is managed by the transport system 40 controlled by the system controller 36.

In the system according to the present embodiment, a bar code reader and a bar code label sticker are provided at required positions on the system.
D number etc. are confirmed. For example, the loading device 52 is provided with a label reader, and a label reader is also provided at a required position of the basic system 42. Further, the dispensing unit 60 described later has a prepared primary mixed sample and a secondary mixed sample. A sticker for sticking a barcode label is provided.

As described above, in the present embodiment, a plurality of basic systems 42 are connected in parallel, and an appropriate number of basic systems 42 can be operated according to the increase or decrease in the number of samples. Here, this basic system 42
Functions as a sample processing station including a plurality of units or devices.

In the basic system 42, two centrifugal units 56 are provided on the transport line. Each centrifugal unit 56 has two rotors 56A to 56D. And those four rotors 56A to 56D
The centrifugal separation process is performed on each sample by appropriately using. Here, by performing such a centrifugal separation process prior to opening, the blood sample adhering to the back side of the stopper of the blood collection tube can be shaken down, and the blood sample generated at the time of opening is scattered. Such problems can be effectively prevented. Therefore, as long as such an effect is obtained, the rotation speed, the rotation time, and the like may be appropriately set. In the present embodiment, each centrifugal unit 56 has an auto balance mechanism and the like.

The original sample after the centrifugation treatment is the opening unit 5
8 The plug opening unit 58 is a device for removing a plug provided above the blood collection tube. Here, in order to more reliably prevent contamination at the time of opening, a protective shutter that can be opened and closed is provided between the opener and the location of the original sample after opening. The original sample after opening is dispensing unit 6
Transported to zero.

The dispensing unit 60 is roughly composed of a first unit 60A and a second unit 60B. First
The unit 60A has, for example, two nozzles, and a first mixed sample is created by the first unit 60A. On the other hand, the second unit 60B has, for example, one nozzle, and a second mixed sample is created by the second unit 60B. Each of the units 60A and 60B has a configuration similar to that of a conventional automatic dispensing apparatus, and aspirates and discharges a sample from a metallic nozzle base and a disposable tip attached to the tip of the nozzle. By the way,
Each disposable chip is automatically exchanged for each sample.

In this embodiment, since two dispensing devices for preparing the primary mixed sample and two dispensing devices for preparing the secondary mixed sample are provided, the two can be operated in parallel to enable efficient processing. . In particular, since there is a difference in the capacity of each dispensing device, N
Dispensing suitable for pretreatment in the AT inspection method can be realized.

In this embodiment, the dispensing unit 60 has a dummy dispensing function. This will be described later in detail with reference to FIG. Incidentally, in order to equalize the concentration of the mixed sample, sample agitation using suction and discharge is performed. The original sample, the primary sample, and the secondary sample after dispensing are sent to the stopper unit 62, respectively.

In the present embodiment, the capping unit 62 comprises a handling unit and a transport mechanism for transporting the handling unit three-dimensionally. The handling unit is for holding the stopper and attaching it to a desired test tube. In this embodiment, the handling unit is configured to be three-dimensionally movable, so that the original sample to which the stopper is attached, There is an advantage that the degree of freedom of the arrangement position of the mixed sample and the secondary mixed sample can be increased.

The discharge unit 64 discharges the sealed original sample. Incidentally, the primary mixed sample and the secondary mixed sample may be further discharged to the discharge unit 64. Alternatively, only the primary mixed sample may be discharged to the discharge unit 64, and the secondary mixed sample may be left on the dispensing unit. Each sample after dispensing is transferred to a predetermined cool box by an artificial operation.

FIG. 4 shows a specific image of the sample processing system according to the present embodiment shown in FIG.

The system configuration described above is an example, and various system configuration examples can be adopted as long as the processes shown in FIG. 1 or FIG. 2 can be realized.

FIG. 5 shows a specific example of the sample correspondence table 51 formed on the storage device 50 shown in FIG. As shown in the figure, a primary mixed sample is associated with a secondary mixed sample, and an original sample is associated with each primary mixed sample. Here, each sample is managed by barcode label information. By storing the correspondence between the specimens in this way, the corresponding specimen can be instantaneously specified at the stage when the NAT test result is obtained,
As a result, there is an advantage that the follow-up of a positive sample can be performed quickly. In addition, it is possible to specify an original sample without errors.

FIG. 6 is a flowchart showing the dummy processing function of the dispensing unit 60. This dummy processing is for supplementing the missing samples by using the dummy samples, and is executed at the time of individual dispensing of each sample, and is also executed when the original sample is eventually insufficient. In addition,
Each step shown in FIG. 6 is executed at the time of creating the primary sample, but the same processing is executed at the time of creating the secondary sample as needed.

In step S101, a predetermined amount of the original sample is aspirated by the nozzle. In S102, the suction abnormality is determined based on the fluctuation of the air pressure in the pipe. here,
If there is no such suction abnormality, in S107, the sucked original sample is discharged to the primary mixed sample container.
After that, the disposable chip is replaced in S108 before the next dispensing of the original sample.

On the other hand, if the suction abnormality is determined in S102, if the discharge is performed as it is, insufficient discharge or the like will occur. In this embodiment, in S103, the sucked original sample is discharged again into the original blood collection tube. Will be returned. Then, in S104, the disposable chip is replaced,
If it is the first abnormality determination in S105, S10 is performed again.
At 1, the original sample is aspirated. If it is determined in step S102 that the suction is normal after such re-suction,
Steps 107 and subsequent steps are executed. On the other hand, when the second abnormality determination is made in S102, S103 to S103
After step 105, step S106 is executed to aspirate the dummy sample.

Here, the dummy sample is placed in the dispensing unit 60.
For example, physiological saline, distilled water, or the like stored and held in a container provided in the above. Various liquids can be selected as those liquids as long as the inspection does not hinder the NAT inspection.

After the dummy sample is aspirated in S106, the dummy sample is discharged to the primary sample container in S107 instead of the original sample for which a suction abnormality has been determined. Then, the disposable chip is replaced in S108 as described above.

In S109, it is determined whether or not the final sample has been processed.
At 111, it is determined whether or not dispensing has been performed for a predetermined number of original samples, that is, whether or not the number of mixtures has reached a predetermined number.
3 and the steps from S101 are repeated. On the other hand, if it is determined in S111 that the mixing number has reached the predetermined number, the primary sample container of the ejection destination is replaced in S112, and S113 and S10
Each step from 1 is repeatedly executed.

If it is determined in step S109 that the processing has reached the final sample, step S110 is executed. In this S110, it is determined whether or not the number of mixtures has reached a predetermined value, similarly to S111. If it is determined that the number of mixtures is still less than the predetermined number even after the final dispensing of the original sample, , S106, the dummy sample is aspirated in the same manner as described above, and is discharged to the primary sample container (S106).
107). Then, in S110, the above steps are repeated until the number of mixing (number of mixing) reaches a predetermined number,
When the number of mixtures reaches the predetermined number, this routine ends.

Therefore, according to the above-described processing, the shortage can be compensated for by using the dummy sample when there is a dispensing abnormality, and when the original sample number is less than the predetermined number, the dummy sample can be used. There is an advantage that a supplementary amount of the primary mixed specimen can be always secured. Further, FIG.
If the processing shown in (1) is also applied to the preparation of a secondary sample, a predetermined amount of a secondary mixed sample having a constant mixing ratio can always be obtained. Therefore, there is an advantage that efficient pre-processing corresponding to the fluctuating number of original samples can be realized. Note that a record of a sample for which substitute dispensing of a dummy sample has been performed is recorded, and an alarm is output as necessary.

[0056]

As described above, according to the present invention,
A sample processing system with high processing capacity can be realized, and in particular, it is possible to flexibly cope with an increase or decrease in the number of samples.

[Brief description of the drawings]

FIG. 1 is a conceptual diagram showing the principle of creating a primary mixed sample and a secondary mixed sample.

FIG. 2 is a conceptual diagram showing each processing step in an inspection center.

FIG. 3 is a block diagram illustrating an overall configuration of a sample processing system according to the present embodiment.

FIG. 4 is a diagram illustrating an actual image of the sample processing system according to the present embodiment.

FIG. 5 is a diagram showing an example of a sample correspondence table.

FIG. 6 is a flowchart of a dispensing process.

[Explanation of symbols]

10 blood collection centers, 12 test centers, 30 original samples, 32 primary mixed samples, 34 secondary mixed samples, 36
System controller, 38 reception device (drawing device), 40 transport system, 42 basic system.

 ──────────────────────────────────────────────────続 き Continued on the front page (72) Inventor Masaaki Takeda 6-22-1, Mure, Mitaka City, Tokyo Aloka Co., Ltd. (72) Inventor Masaaki Hibino 6-22-1, Mure, Mitaka City, Tokyo Aloka Co., Ltd. (72) Inventor Hiroaki Niwayama 6-22-1 Mury, Mitaka-shi, Tokyo Aloca Inc. F-term (reference) 2G058 AA09 BA06 CA02 FA01 GC02 GC05 GC09 HA00 4B024 AA11 AA19 HA11 4B063 QA01 QQ03 QQ21 QQ41 QQ61 QS10 QS11 QS QS39

Claims (10)

[Claims] 1. A primary dispensing means for collecting a fixed amount from m original samples and mixing them to form a primary mixed sample, and collecting a fixed amount from n primary mixed samples and mixing them A secondary dispensing means for preparing a secondary mixed sample by performing the above procedure; a storage means for storing a correspondence relationship between the original sample, the primary mixed sample and the secondary mixed sample; And a tracking means for referring to the correspondence relationship when specified, and identifying a primary mixed sample and an original sample corresponding to the positive sample. 2. The system according to claim 1, wherein the original sample, the primary mixed sample, and the secondary mixed sample are managed by a label including sample identification information, and the sample identification information of each sample is stored in the storage unit. A sample processing system, wherein the sample processing system is registered. 3. The system according to claim 1, further comprising mixing number setting means for variably setting parameters m and n, wherein said primary dispensing means and said secondary dispensing means are set by said mixing number setting means. A sample processing system that operates according to the set mixing number condition. 4. The system according to claim 1, wherein a dummy sample holding means for holding a dummy sample, and when the number of samples is insufficient when n primary mixed samples are created, the number of the dummy samples is equal to the shortage. A sample processing system, comprising: fraction processing means for executing dispensing. 5. The system according to claim 1, wherein a dummy sample holding means for holding a dummy sample, and when a sample suction abnormality is detected, according to a predetermined condition.
And a suction abnormality countermeasure for executing dispensing of the dummy sample instead of the sample. 6. A sample processing system including at least one sample processing station, wherein said sample processing station collects a predetermined amount from an m number of original samples after opening the opening device for opening the original sample. A primary dispensing device that mixes them to create a primary mixed sample, and a secondary dispensing device that collects a fixed amount from n primary mixed samples and mixes them to create a secondary mixed sample. A sample processing system, comprising: a stopper device for closing each of the above samples. 7. The apparatus according to claim 6, wherein the sample processing station performs a centrifugal separation process on the original sample prior to the opening to prevent droplets from being scattered at the time of opening. A sample processing system comprising a device. 8. The sample processing system according to claim 6, wherein the capping device includes: a handling unit that grasps a stopper; and a robot mechanism that three-dimensionally transports the handling unit. 9. The system according to claim 6, further comprising a sample extracting device that performs a pass / fail test on each of the original samples and extracts an unsuitable sample before inputting the original samples into the sample processing station. Sample processing system. 10. A plurality of sample processing stations that can operate in parallel with each other, an original sample supply device that distributes an original sample to the plurality of sample processing stations, and an operation management device that performs operation management of the plurality of sample processing stations. In each of the sample processing systems, each of the sample processing stations includes an opening device for opening the original sample, and a certain amount collected from the m original samples after opening, and mixing them to perform primary mixing. A primary dispensing device that creates a sample, a secondary dispensing device that collects a fixed amount from n primary mixed samples, mixes them to create a secondary mixed sample, and plugs each of the above samples A sample processing system, comprising: a capping device.