JP2001114691A - Intraintestinal product-deodorizing composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain the subject composition containing, as active ingredient(s), raffinose and, if needed, composite-type dietary fibers such as beet fibers. SOLUTION: This composition containing the above substance(s) as active ingredient(s) is such as to diminish or entirely eliminate offensive odor emitted from offensive odor-generating gaseous to solid substances produced intraintestinally such as feces.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to the deodorization of intestinal products, and more particularly, to intestinal malodors such as feces and intestinal gas using raffinose and, if necessary, complex dietary fiber. The present invention relates to a technique for removing odors from generated products.

[0002]

2. Description of the Related Art In recent years, interest in odors has increased,
Tolerance to foul odors is generally decreasing, and effective measures are required even among healthy persons. Among the offensive odors, fecal odor derived from feces has become a problem especially in hospitals and nursing homes, but there is still no odor that can be satisfied with an efficient deodorizing system that has an excellent deodorizing effect and has both safety and convenience. It has not been developed yet.

[0003]

When nursing a bedridden elderly person or a patient wearing a diaper, the treatment of excrement, especially the treatment of feces, is one of the important tasks. Odors from feces are mentioned. If there is no smell of stool, diaper change and subsequent processing can be performed easily, and it is a great good news and help not only for the caregiver but also for those who are in the room such as the hospitalized room. Also,
A colectomy patient with a colostomy can freely attach and detach the colostomy without worrying about the smell, and even if there is some leakage, it does not make the surroundings uncomfortable.

[0004] If the odor can be efficiently removed from the stool in this manner, the treatment of the stool, which is one of the causes of troubles at the time of nursing care and the like, should not be a particularly troublesome treatment. In addition, it is not necessary to say that it is unpleasant odor caused by feces such as fecal odor even in healthy persons and ordinary households, and it is preferable to remove it.

[0005] In recent years, dogs, cats and other pets have been often bred especially indoors, and the odor caused by the feces of the pets has been highlighted. This point
It has been recognized in pet farms, animal hospitals, livestock farms such as pig farms, and even zoos, and it has been required not only for humans but also for animals to reduce or eliminate the bad smell of feces.

[0006]

SUMMARY OF THE INVENTION The present invention has been made to solve the above-mentioned problems and to develop a new system for reducing or completely eliminating fecal odor. As a result of diligent studies and studies from various fields, oral administration of raffinose not only eliminated the smell of feces, but also eliminated the smell of exhausted gases and reduced raffinose against various substances produced in the intestine. For the first time, they found that they have a deodorizing effect, and as a result of further research, completed the present invention.

Further, it has been confirmed that the effect is enhanced when dietary fiber is used in combination, and that the present invention has an effect of promoting defecation. Furthermore, the effect of the present invention is exerted not only on humans but also on animals. This was also confirmed, and the present invention was completed based on these useful new findings.

[0008] That is, the present invention relates to a composition for deodorizing intestinal products characterized by containing raffinose (and complex dietary fiber) as a main component.

As raffinose, it is possible to use a purified oligosaccharide consisting of one molecule of D-galactose, D-glucose and D-fructose, and it is also possible to extract raffinose from molasses produced as a by-product when producing sugar beet. It is also possible to use crude products such as raffinose-containing products obtained by separation, and purified raffinose obtained therefrom.

[0010] The composite dietary fiber used in the present invention contains both water-soluble fiber and water-insoluble fiber. In general, fiber materials derived from plants include pectin, hemicellulose, cellulose and lignin. And the like. Beet fiber, wheat bran, rice bran,
One or more of corn fiber, apple fiber, soy fiber and the like can be mentioned.

The composition of the present invention orally administers the composition to deodorize intestinal products. In the present invention, the reduction of odor and the complete elimination thereof are all included in the deodorization. In addition, the intestinal products include all of gaseous to liquid to paste to semi-solid to solid products generated in the intestine, and include intestinal exhaust gas and the like in addition to feces. Included. In addition, ordinary feces is water 7
0-80% is referred to as stool of which constipation is 70% or less of water, and feces of diarrhea is 80% or more of water. The present invention covers all of these stools. In the present invention, animals also include humans.

The composition according to the present invention contains raffinose as an active ingredient, but may further contain a complex dietary fiber. In the latter case, the ratio of raffinose to the complex type dietary fiber is effective even if it is optional, but it is usually preferable to set the ratio of both to 10: 1 to 1:10.
The ratio is preferably 5: 1 to 1: 5, and most preferably 2: 1. Each of the active ingredients is a food or a food-related substance, and has no particular toxicity. As a result of a 10-day acute toxicity test using mice, 1000
No deaths were observed even after oral administration of mg / kg.

The detailed mechanism of the deodorizing action of the composition according to the present invention must be clarified in future studies, but at present, the following is considered. First, raffinose suppresses intestinal spoilage products, improves intestinal bacterial flora,
It is considered to have an effect of improving stool, adjusting the water content of feces, etc., and these effects work synergistically, and / or the effect of directly deodorizing the unique malodor of raffinose, thereby efficiently deodorizing. .

On the other hand, the dietary fiber includes a water-soluble dietary fiber, a composite dietary fiber, and a water-insoluble fiber. The water-soluble fiber activates the activity of the intestinal flora and slightly increases the amount of feces. Furthermore, since the fiber reaches the large intestine in a liquid state, it has a drawback that the osmotic pressure is increased and rapid fermentation and diarrhea are induced. On the other hand, water-insoluble dietary fiber increases the amount of feces but does not affect the activity of intestinal flora. Compared to these water-soluble and water-insoluble dietary fibers, conjugated dietary fiber is water-insoluble in the intestine, has no burden on the intestine as seen in water-soluble fiber, has slow fermentation, and peristalsis in the large intestine. It is suitable for excretion of ordinary feces, such as promotion and increase of feces, and is also related to deodorization of feces, and further enhances the deodorizing effect of raffinose. In addition, as described above, raffinose (and complex dietary fiber) has useful effects such as deodorization of various intestinal products, promotion of defecation, and improvement of constipation.

When used as a food or drink type composition, the present active ingredient can be used as it is or in combination with other foods or food ingredients, and can be used according to a conventional method as appropriate. The composition according to the present invention using the present active ingredient,
It may be solid (powder, granule, etc.), paste, liquid or suspension, but it is formulated into a drink using sweeteners, sours, vitamins and other ingredients commonly used in the production of drinks. It is also possible.

When used as a pharmaceutical type composition, the active ingredient is administered in various forms. Examples of the administration form include tablets, capsules, granules, powders,
Oral administration using a syrup or the like can be mentioned. These various preparations are commonly used in the pharmaceutical preparation technical field such as excipients, binders, disintegrants, lubricants, flavoring agents, solubilizing agents, suspending agents, coating agents, etc. in the main drug according to the usual method. It can be formulated using known adjuvants.

The active ingredient of the raffinose or raffinose-containing composition according to the present invention is 1 as raffinose.
５5 g (per meal) is appropriate, and the active ingredient of the composition containing raffinose and complex dietary fiber as main components is
0.1 to 10 g, preferably 1 to 4.5 g, 2-3 times a day
By taking the medicine during the meal, between meals and after the meal, the bad smell of the intestinal products can be reduced or eliminated. For example, changing a diaper for a bedridden elderly person can be carried out smoothly without giving the caregiver and surrounding people a bad odor. Since there is no residue, the next person can use the toilet immediately. In addition, constipation can be improved by taking the product of the present invention before and after meals by a person having a problem with constipation, which also contributes to deodorization of intestinal products.

The animals include small animals such as dogs and cats bred at home, as well as animals bred at home and zoos. At this time, the present active ingredient may be prepared individually without preparation, and may be directly added to pet food or other normal animal feed or drinking water as it is, or if necessary, contains the active ingredient in advance. Pet food or premixes may be manufactured. Hereinafter, examples of the present invention will be described.

[0019]

Example 1 (Preparation of intestinal product deodorizing composition 1) In producing sugar beet, molasses and sugar beet pulp produced as by-products are used as raw materials. After separating the raffinose fraction from molasses by chromatography, the fraction is concentrated, crystallized and used as raffinose pentahydrate.

On the other hand, sugar beet pulp refers to a residue obtained by cutting or grinding, squeezing and squeezing sugar beet root into strips and then immersing the mixture in warm water to sufficiently extract and remove soluble components mainly composed of sucrose. This sugar beet pulp is decolorized, deodorized, dried, crushed,
Necessary treatment such as sieving is performed, and this is used as a beet fiber. This beet fiber is used as a powder having 30 mesh through, more preferably 10 mesh through.

After finely pulverizing the raffinose crystal, the raffinose crystal is uniformly mixed with the beet fiber powder at a weight ratio of 2: 1.
Water 10 (weight ratio) was added to the uniformly mixed mixture 100, and the mixture was uniformly mixed. The mixture was then extruded with a granulator (FINERYUZER Model E, manufactured by Fuji Paudal Co., Ltd.).
XR-60, granulation at processing capacity of 40-150 kg / hr), drying for 3 hours in a blast low temperature incubator at 70 ° C (Yamato Scientific Co., Ltd. model DN910) for 3 hours, and granular 3 g per packet of the present invention Obtain the composition. Because it is a granular composition, it can be eaten and drink smoothly without getting caught in the throat. On the other hand, the paste-like composition is prepared by dissolving and dispersing raffinose and beet fiber powder in a ratio of 2 to 1 in about 8 to 10 times of water, sterilizing and packaging in the form of a plastic container, a bottle or a can. Can be In the case of a paste, other nutrients such as vitamins, minerals, proteins, and sugars may be used in combination.

[0022]

Example 2 (Preparation of intestinal product deodorizing composition 2) The concentration of molasses (rBx80) derived from beet sugar was diluted to rBx60, and the diluted solution was applied to a chromatographic separator (a multi-component separator using a simulated moving bed: Organo). Supply, sweet oligo fraction 540
0 L was collected. The method for collecting the sweet oligo fraction (hereinafter also referred to as the SO fraction) is to separate the sucrose and disaccharide from sucrose and disaccharides that are separated by ash, polysaccharides and derivatives thereof, raffinose and other trisaccharides after chromatographic separation. Trisaccharide ratio 2-7
Was collected as a sweet oligo fraction. This SO
The fraction concentrated to rBx60 is used as a sweet oligo fraction concentrate (SO). The composition of SO was as follows. rBx 60 trisaccharide 19 SD% (inner raffinose 16 SD%) sucrose 75 SD% monosaccharide 2 SD%

(Deodorizing Effect of Intestinal Product Deodorizing Composition) The above-mentioned SO is used for healthy persons (I to H) who have normal defecation habits.
10 g was added to coffee, tomato, yogurt and the like, and they were eaten (after each meal). This was continued for five days.
After defecation, 便 indicates no feeling of fecal smell, Δ indicates slight feeling, and X indicates many feelings. The results obtained are shown in the table below. As is clear from the results, it was demonstrated that the present invention exerted an excellent deodorizing effect, and the intestinal gas released during the test was examined for its odor. The name showed the disappearance of the odor or a significant decrease, and the other two also showed a decrease.

(Table 1) Day 0 × × × × × × × × Day 1 △ △ × × △ △ △ △ Day 2 △ ○ △ △ ○ △ △ ○ Day 3 Day ○ ○ △ △ ○ △ △ ○ Day 4 ○ ○ ○ △ ○ △ ○ ○ Day 5 ○ ○ ○ ○ ○ ○ ○ ○

[0025]

Example 3 (Deodorizing effect of intestinal product deodorizing composition) The granular composition obtained in Example 1 was used. The granular composition was given to patients with constipation (AG) who had bowel movements no more than once every two days. 1 cup (3g) for morning, lunch and dinner
Eat with ~ 2 glasses of water. This was continued for five days. For those who have bowel movements, ask them to examine the fecal odor.
In addition, a person who did not defecate was marked with-. The results obtained are shown in Table 2 below. As is clear from the results, it was demonstrated that the present invention exerts an excellent deodorizing effect.

[0026]

As is clear from the above results, it was proved that the composition of the present invention not only deodorized the feces of constipation patients very efficiently, but also exhibited an excellent defecation promoting effect. Was. In addition, about the amount of stool, 4 out of 7 people
No patient reported that the number had increased and had decreased.

[0028]

Example 4 Preparation of Intestinal Product Deodorizing Composition 3 Granular raffinose prepared by extruding and granulating the raffinose pentahydrate crystals prepared in Example 1 is used. Also, crystalline raffinose and other nutrients, for example, minerals, vitamins, proteins, sugars and the like are used in combination to form a formulation, and granules and pastes are used.

(Improvement of bowel movements of bedridden elderly and reduction of fecal odor) The bedridden elderly were asked to take 4 g of the above granular raffinose during each meal. A dosing test was performed for three days.
Conventionally, the smell was strong when the diaper was changed, but the smell was greatly reduced one day after taking the diaper, and the smell was almost eliminated on the third day. Similarly, the other three were tried with similar results. This test also improved bowel movements for all four.

[0030]

Example 5 (Improvement of animal bowel movement and reduction of fecal odor) Intestinal product deodorizing composition (containing raffinose and beet fiber) of Example 1 in guide dog Laplacley Red River 3
g (every meal) was sprinkled with pet food. As a result, it was confirmed that the bad smell in the conventional feces had almost disappeared two days later, and at the same time, the improvement of the bowel movement was also recognized.

[0031]

According to the present invention, malodors derived from intestinal products such as feces can be reduced or completely eliminated, so that malodors derived from excretions in general households, hospitals, nursing homes and the like can be obtained. , Life can be comfortable and the caregiver's work is greatly reduced. In addition, the stool collection and the inspection itself in an inspection such as a stool test can be performed without any discomfort. Furthermore, the present invention can be widely applied to not only humans but also various animals, and is very suitable for modern life in which many people live in closed spaces such as condominiums.

──────────────────────────────────────────────────の Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61P 1/14 A61P 1/14 // C07H 3/06 C07H 3/06 (72) Inventor Katsuaki Ohno Tokyo 2-3-13 Kyobashi, Chuo-ku Nippon Sugar Beet Sugar Co., Ltd. F-term (reference) 4C057 BB01 BB04 4C086 AA01 AA02 EA01 MA01 MA02 MA04 MA07 ZA66 ZA73 4C088 AB12 AB51 AB61 AB73 AB74 AB78 AC04 BA09 BA12 MA52 ZA66 ZA73

Claims (6)

[Claims] An intestinal product deodorizing composition characterized by containing raffinose or a raffinose-containing substance as a main component. 2. An intestinal product deodorizing composition comprising raffinose and complex dietary fiber as main components. 3. The composite dietary fiber is beet fiber,
The composition according to claim 1 or 2, wherein the composition is at least one selected from wheat bran, rice bran, corn fiber, apple fiber, and soy fiber. 4. The method of claim 1, wherein the ratio of raffinose to complex dietary fiber is from 10: 1 to 1:10.
The composition according to any one of claims 1 to 3. 5. The composition according to claim 1, wherein the composition is a food or beverage type or a pharmaceutical type composition. 6. An intestinal product deodorizing composition for animals other than humans, characterized by further comprising raffinose and, if necessary, a complex type dietary fiber as a main component.