JP2001054571A - Blood plasma purifying device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To embody a blood plasma purifying device which lessens the burden on a patient by lessening the amount of circulating liquid to be admitted into the patient and is improved in the reliability of recovery operation. SOLUTION: This blood plasma purifying device captures the blood by a blood pump BP disposed in a blood specimen collection circuit, feeds the blood into a blood plasma separator 1, introduces the blood plasma separated from this blood plasma separator 1 by a blood plasma pump PP to a blood plasma component separator 2 disposed in a blood plasma circuit to separate the blood plasma to a high-molecular weight component and a low-molecular weight component, introduces the high-molecular weight component by a replacement pump RP to a discharge path C to discharge, supplies a replenisher solution to the low-molecular weight component by a replenisher solution supply means 3, joins this low-molecular weight component and the blood past the blood plasma separator and returns the blood through a blood return circuit E. After the end of the blood purification treatment, the low-molecular weight component and blood stagnating in the purifying device described above are extruded by the air and are recovered into the body.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

The present invention relates to a method for separating plasma separated from blood into a high molecular weight component and a low molecular weight component, discharging high molecular weight components containing harmful substances, and supplying a replacement fluid for the low molecular weight component. More specifically, the present invention relates to a plasma purification device having a recovery means for returning blood and plasma remaining in the device after purification to the body using air by using a double filtration membrane method for returning the blood to the body.

[0002]

2. Description of the Related Art One of the methods for treating blood for the purpose of treatment is to separate plasma from blood, further separate it into high molecular weight components and low molecular weight components, and then remove harmful and unnecessary substances. A so-called plasma double filtration membrane method is known in which a high molecular weight component containing is discharged, and a low molecular weight component is supplied with a replacement fluid in place of the discharged high molecular weight component to be combined with the original blood and returned.

FIG. 2 shows an apparatus for performing a plasma treatment by a double filtration membrane method. A blood collection circuit A for taking blood collected through a blood pump BP into a circuit and feeding the blood to a plasma separator 1 is provided with a plasma collection circuit A. A plasma circuit B for guiding the plasma separated by the separator 1 to a plasma component fractionator 2 by a plasma pump PP to separate it into a high molecular weight component and a low molecular weight component, and then returning the low molecular weight component. A discharge path C for discharging by a pump RP, a replacement fluid supply path D for connecting the replacement fluid supply means 3 to the plasma circuit via a replacement fluid pump RP, and a low molecular weight component supplied with replacement fluid and blood passing through the plasma component separator 2. And a blood replenishing circuit E that combines the fluid and the replacement fluid and then returns the blood.

[0004] In Fig. 2, a dual type pump capable of simultaneously mounting two tubes for a high-molecular-weight component discharge channel and a tube for a replacement fluid supply channel is used as the replacement liquid pump RP, and can be simultaneously executed by a pump through the discharge channel. It is configured as
Equivalent exchange between high molecular weight components of plasma and replacement fluid is guaranteed.

At key points in the circuit, pressure detectors P3, P5,
Drip chambers D1, D2, D4, D6, D7 provided with pressure detectors P1, P2, P4, P6, P7 are provided, and valves V1 to V4 for opening and closing and switching control of a flow path are provided.
In addition to V10, V13 to V15, a physiological saline injector 4 for washing the circuit and collecting residual blood, a heparin injector HP for preventing blood coagulation, and blood leakage in plasma flowing out of the plasma separator 1. Blood leak detector 5 for detecting
A warmer HT for warming the returned blood to a predetermined temperature, a bubble detector 6 for detecting the incorporation of bubbles in the returned blood, a liquid out detector 8 for confirming the supply of physiological saline 7 and replacement fluid. , 8a and other necessary equipment are provided.

Operation of blood pump BP, plasma pump PP, replacement liquid pump RP and valves V1 to V10, V13 to V
The opening and closing operation of the device 15 and the pressure detectors P3 and P
5 based on a detection signal from the CPU 5 and the like.
18 and a control device including a ROM 19 and the like.

The valves V1 to V10 and V13 to V15 are
Open / close control is performed in conjunction with each of the pumps BP, PP, and RP, and the flow path is automatically switched for each process.
That is, a preparatory step for mounting the circuit and washing with the physiological saline solution 7 before the start of the processing, a step of introducing blood into the circuit to perform plasma processing by double filtration, and a step of collecting blood remaining in the circuit after the processing. When executing such operations as described above, the control means controls the valve V so that a flow path corresponding to each step is formed.
Open / close of 1 to V10 and V13 to V15 are operated.

Next, a method for treating plasma by the above-mentioned purifying apparatus will be described. In the following description, each pressure detector P1,
The pressures measured at P2...
It will be described as 2 ...

In the configuration shown in FIG. 2, prior to the execution of the plasma treatment, the circuit is mounted and the inside of the circuit is washed with the physiological saline 7. After the necessary preparation process is completed, the blood pump BP is started to operate, blood is taken from the blood collection end of the blood collection circuit A into the circuit, and is sent to the plasma separator 1.

[0010] The plasma separated by the plasma separator 1 is guided to the plasma component fractionator 2 by the plasma pump PP, where it is separated into a high molecular weight component and a low molecular weight component. Among them, the high molecular weight component contains harmful substances and unnecessary substances, which are discharged through the discharge path by the replacement liquid pump RP.

The replacement liquid pump RP is equipped with a replacement fluid supply tube and a high molecular weight component discharge tube.
Because it is a continuous type, at the same time as discharging high molecular weight components,
An equivalent amount of the replacement fluid 9 is supplied from the replacement fluid supply means 3 to the low molecular weight component through the replacement fluid supply passage D.

The low-molecular-weight component supplied with the replacement fluid merges with the blood that has passed through the plasma separator 1 and is returned through the heater HT. When a predetermined amount of plasma processing is completed, the physiological saline 7 is introduced, and the plasma and blood remaining in the circuit are collected. Note that the valve V12 is used during circuit cleaning and is normally closed.

[0013]

By the way, in such an apparatus, the physiological saline 7 is introduced in order to collect the blood remaining in the circuit (return to the body).
In that case, it is difficult to return only the blood, and extra physiological saline 7 is mixed. Therefore, the burden on the patient increases.

Although it is conceivable to use air instead of the physiological saline 7, manual collection such as securing of the intake port, operation of forceps by manual operation, and confirmation of the air flow path requires complicated operations. The present invention has been made to solve the above-mentioned problem. The inlet and the outlet of the plasma component fractionator 2 are connected by a dummy tube, and the ROM 11 of the control device shown in FIG.
It is an object of the present invention to realize a blood purification apparatus capable of automatically collecting blood by air by adding a blood collection procedure to the blood purification apparatus. .

[0015]

In order to achieve the above object, according to the first aspect of the present invention, blood is taken in by a blood pump provided in a blood collection circuit, sent to a plasma separator, and the plasma is separated from the blood. The plasma separated from the blood by the separator is guided to a plasma component fractionator provided in the plasma circuit by a plasma pump to separate the high molecular weight component and the low molecular weight component, and the high molecular weight component is guided to a discharge path by a displacement pump. A blood purification device that discharges and supplies a replacement fluid to the low molecular weight component by a replacement fluid supply unit, and then combines the low molecular weight component with blood passing through the plasma separator and returns the combined blood through a blood return circuit. After the purification process is completed, the low-molecular-weight component and blood staying in the purification device are extruded by air and collected in the body.

According to a second aspect of the present invention, in the plasma purifying apparatus according to the first aspect, when the low-molecular weight component staying in the plasma component fractionator is pushed out by air and collected in the body, the plasma component fractionator is used. In order to prevent the recovery of high molecular weight components remaining in the plasma, a primary tube of the plasma component separator is bypassed, and a dummy tube for supplying air when collecting plasma in the plasma circuit is provided.

According to a third aspect of the present invention, in the plasma purifying apparatus according to the first aspect, when the low-molecular-weight component remaining in the plasma component fractionator is pushed out by air and collected in the body, it is connected to the replacement fluid supply means. The removed needle is removed and air is supplied from the removed portion.

According to a fourth aspect of the present invention, in the plasma purifying apparatus according to the first aspect, when blood remaining in the plasma separator is collected into the body by air, the blood is first collected by a collection liquid, and then the collected liquid is collected by air. It is characterized by being pushed out and collected inside the body. According to a fifth aspect of the present invention, in the plasma purifying apparatus according to the fourth aspect, when blood staying in the plasma separator is collected into the body by air, a needle connected to the collected liquid is removed in advance, and the blood is extruded by air. It is characterized in that it is to be collected.

[0019]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described below in detail with reference to the drawings. FIG. 1 shows an example of an embodiment of the present invention, and is different from FIG. 2 shown as a conventional example in that an inlet and an outlet of a plasma component fractionator 2 are connected by a dummy tube 20 so that plasma The only difference is that the inflow of blood is prevented, and the sequence of the blood collection sequence using air is added to the ROM 11 of the control device shown in FIG.

Next, the operation of the apparatus will be described. After the treatment is completed, as a preparation stage, the primary entrance and exit of the plasma component fractionator 2 are stopped with forceps, removed from the circuit, and replaced with a dummy tube 20. A blood collection needle (not shown) is removed from the patient, and the needle is connected to a physiological saline (recovery solution) 7. The needle connected to the physiological saline (recovery liquid) 4 is removed.

Next, when a collection button (not shown) is pressed,
The sequence written in the ROM 11 of the control device shown in FIG. 2 is started. As a result, the control device opens the valve 13,
The other valves are closed, and only the blood pump BP is rotated forward (the pumps PP and RP are stopped) so that the processing amount of the BP is set to a specified value (this specified value is set in advance from the volume of the plasma separator 1 and the blood return circuit E). The blood in the blood separator 1 is collected (within the body) using the collected liquid until the blood pressure is reduced.

This step is not preferable in that the physiological saline (recovered liquid) 7 is mixed into the body, but the volume of the blood return circuit E is 50 to 100 C even if the volume of the plasma separator 1 is included.
Since it is about C, the burden on the patient does not increase.

Next, the control device stops the blood pump BP, opens V3, V4, and V13, closes V10, and reverses the plasma pump PP. As a result, the plasma between the secondary side of the plasma separator 1 and the inlet (point X) of the plasma component separator 2 is pushed back from the secondary side of the plasma separator to the primary side and collected by the air taken in from the V3 part. .

It is to be noted that liquid can pass through the primary ← → secondary side of the plasma separator 1 but air cannot pass through it. Here, the secondary side of the plasma separator 1 is pressurized with air and collected until the pressure of the pressure gauge P3 measuring the air pressure exceeds a specified value. The determination as to whether or not the predetermined value is exceeded is made by automatically storing a predetermined value in the control device.

Next, the plasma pump PP is stopped, and V1, V
3, V6, V8, V9, V13 open, V2, V4, V
5, V7, V10 are closed, and the replacement liquid pump RP is rotated forward. As a result, the air taken in from V1 drives out the plasma on the secondary side of blood component fractionator 2 and collects the plasma.

In this operation, the taken-in air is returned to the blood return circuit E.
And returns to the drip chamber D7 provided until the liquid level in the blood return chamber D7 drops. The volume including the secondary side of the blood component fractionator 2, the replacement fluid supply path, and the plasma circuit is 300 to 400.
cc.

Subsequently, when performing re-air recovery of blood,
Remove the needle connected to the physiological saline (recovery solution) 7,
Press the collection button again. As a result, the control device
V14 is opened according to the sequence written in 1,
Rotate blood pump BP forward. As a result, the plasma separator 1
The physiological saline solution inside pushes out the air in the blood return circuit E, and this air flows out from V14 provided in the drip chamber D7. Thereafter, physiological saline flows in after the air and reaches a predetermined level. Next, the valve V14 is closed and V13 is opened to collect the physiological saline solution into the body.

It is to be noted that the above description of the present invention has been presented by way of explanation and illustration only of particular preferred embodiments. Thus, it will be apparent to one skilled in the art that the present invention may be modified or modified in many ways without departing from its essentials. The scope of the present invention, which is defined by the description in the appended claims, is intended to cover alterations and modifications within the scope.

[0029]

As described above, according to the present invention, after the blood purification process is completed, the low molecular weight components and blood staying in the purification device are extruded by air and collected in the body. The amount of liquid entering the patient can be reduced, and the burden can be reduced. Further, starting / stopping of each pump and opening / closing of each valve are automatically performed based on a sequence written in advance, so that safety and reliability can be improved more than in the case where manual operation is performed.

[Brief description of the drawings]

FIG. 1 is a schematic diagram showing a circuit configuration showing an example of an embodiment of a blood purification processing apparatus according to the present invention.

FIG. 2 is a diagram schematically illustrating a control device used in the related art and the present invention.

FIG. 3 is a schematic diagram showing a circuit configuration of a conventional blood purification processing apparatus.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Plasma separator 2 Plasma component fractionator 3 Replenisher supply means 4,7 Physiological saline injector 5 Blood leak detector 6 Bubble detector 8 Out-of-liquid detector 9 Replenisher 20 Dummy tubes D1-D7 Drip chambers P1-P5 Pressure gauge V1 to V10, V12 to V15 valves BP Blood pump PP Plasma pump RP Replacement liquid pump A Blood collection circuit B Plasma circuit C Discharge path D Replenisher supply path E Blood return circuit

Claims (5)

[Claims] 1. A blood pump provided in a blood collection circuit takes blood and sends it to a plasma separator, and the plasma separated from the blood by the plasma separator is supplied to a plasma component fractionator provided in the plasma circuit by a plasma pump. After being separated into a high-molecular-weight component and a low-molecular-weight component, the high-molecular-weight component is guided and discharged to a discharge path by a displacement pump, and after a replacement fluid is supplied to the low-molecular-weight component by replacement fluid supply means, the low-molecular-weight component and In a blood purification apparatus that combines blood passing through the plasma separator and returns the blood through a blood return circuit, after the blood purification processing is completed, the low molecular weight components and blood remaining in the purification apparatus are pushed out by air to remove the blood from the body. A blood purification apparatus characterized in that it is collected in a blood purification apparatus. 2. When the low molecular weight component staying in the plasma component fractionator is pushed out by air and collected in the body, the high molecular weight component staying in the plasma component fractionator is not collected, so that the plasma component fraction is not collected. 2. The plasma purification device according to claim 1, further comprising a dummy tube that bypasses a primary side of the painter and supplies air for collecting plasma in the plasma circuit. 3. When the low molecular weight component staying in the plasma component fractionator is pushed out by air and collected in the body, a needle connected to the replacement fluid supply means is removed and air is supplied from the removed portion. 2. The plasma purification device according to claim 1, wherein the plasma purification device is used. 4. The method according to claim 1, wherein when the blood remaining in the plasma separator is collected into the body by air, the blood is previously collected by a collection liquid, and then the collection liquid is extruded by air and collected in the body. The plasma purification device according to claim 1. 5. The method according to claim 5, wherein when collecting blood retained in said plasma separator into the body by air, a needle connected to the collected liquid is removed in advance and extruded by air to collect the blood into the body. The plasma purification device according to claim 4.