JP2001031580A - Preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To improve the unsatisfactory effect of a preparation for external use for skin to a satisfactory level, for example, insufficient anti-inflammatory effect of a preparation for external use for skin containing only anti- inflammatory agent as an active ingredient, or cannot attain a desired level of the effect due to its deterioration in the preparation. SOLUTION: This preparation for external use for skin comprises (A) an extract from fruits of a fruit tree (Myrciari Dubia) in the family Myrtaceae extracted by using an extraction solvent and (B) an anti-inflammatory agent.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

[0001] The present invention relates to an external preparation for skin, and more particularly, to a skin preparation containing a camcam extract and an anti-inflammatory agent to suppress inflammation such as hot flashes and erythema after sunburn. The present invention relates to an external preparation for skin such as cosmetics and external medicine having an excellent anti-inflammatory effect and a whitening effect on the skin.

[0002]

2. Description of the Related Art Conventionally, various medicinal ingredients have been added to skin external preparations such as emulsions, creams, lotions, packs, detergents, ointments, dispersions, and external preparations for the purpose of anti-inflammatory and whitening. I have. For example, anti-inflammatory agents such as glycyrrhizic acid, indomethacin, aloe extract, chamomile extract and the like are added for the purpose of calming inflammation such as hot flashes and erythema of the skin after sunburn and suppressing the occurrence of pigmentation and the like. ing.

[0003]

However, skin external preparations containing these anti-inflammatory agents, such as cosmetics and external medicines, do not have sufficient effect of the anti-inflammatory agent or may deteriorate in the preparation. In many cases, the desired medicinal effect cannot be obtained, and improvement has been desired.

[0004]

Means for Solving the Problems The present inventors diligently improve the effect of an anti-inflammatory agent added to a topical skin preparation for the purpose of suppressing inflammation such as hot flashes and erythema of the skin after sunburn and whitening. As a result of research, they have found that the combination of a camcam extract and an anti-inflammatory agent can sufficiently exert the action originally possessed by the anti-inflammatory agent, and completed the present invention.

[0005] That is, the present invention provides an external preparation for skin characterized by containing the following components (A) and (B): (A) a cam-cam extract; and (B) an anti-inflammatory agent.

[0006]

BEST MODE FOR CARRYING OUT THE INVENTION The cam cam extract which is the component (A) of the present invention is a cam cam (Myr) which is a fruit tree of the family Myrtaceae.
ciaria Dubia) using an extraction solvent. The preparation method is not particularly limited, but, for example, extraction is performed at low temperature or at room temperature to heating using various suitable solvents.

As the extraction solvent, for example, one or more of water; lower monohydric alcohols such as methyl alcohol and ethyl alcohol; and liquid polyhydric alcohols such as glycerin, propylene glycol and 1,3-butylene glycol are used. be able to. As an example of a preferred extraction method, extraction is performed at a low temperature for 2 to 3 days using ethyl alcohol having a water content of 20 to 90% (v / v), followed by filtration, and the obtained filtrate is left for about 5 days. And then aging and filtering again.

The content of the cam cam extract, which is the component (A) of the present invention, is 0.0001 as a dry solid content in all the components.
To 5% by weight (hereinafter simply referred to as "%"), preferably 0.001 to 3%. When the content of the camu cam extract is in this range, the effects of the present invention are better exhibited.

As the anti-inflammatory agent which is the component (B) of the present invention, the following are preferred.

Preferred anti-inflammatory agents include zinc oxide, sulfur and derivatives thereof, glycyrrhizic acid and its derivatives such as glycyrrhizic acid, dipotassium glycyrrhizinate and monoammonium glycyrrhizinate, and derivatives thereof, β-glycyrrhetinic acid, stearyl glycyrrhetinate and 3-succinyl. Glycyrrhetinic acid and its derivatives such as disodium oxyglycyrrhetinate and its derivatives, tranexamic acid and its derivatives, chondroitin sulfate and its derivatives, mefenamic acid and its derivatives, allantoin and its derivatives, guaiazulene and its derivatives, phenylbutazone, indomethacin, ibuprofen, ketoprofen , Ε-aminocaproic acid, diclofenac sodium and the like. Note that these “derivatives” also include salts that can be formed.

Among these anti-inflammatory agents, particularly preferred are zinc oxide, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, chondroitin sulfate and its derivatives, allantoin and its derivatives, and guaiazulene and its derivatives.

Other preferable examples of the anti-inflammatory agent include aloe extract, Altea extract, Ashitaba extract, Arnica extract, cling extract, nettle extract, turmeric extract, oak extract and hypericum extract , Chamomile extract, licorice extract, goldfish extract, watercress extract, comfrey extract, salvia extract, siconium extract, perilla extract, birch extract, calendula extract, elder extract, squirrel extract ,
Examples include a mud mallow extract, astragalus extract, mugwort extract, gentian extract, licorice extract and eucalyptus extract.

Among these anti-inflammatory agents, particularly preferred are aloe extract, nettle extract, hypericum extract, licorice extract, comfrey extract, birch extract, perilla extract, and sapling extract. Can be

The content of the anti-inflammatory agent as the component (B) of the present invention is preferably 0.0001 to 5% by weight, more preferably 0.001 to 3% by dry solid content. When the extract is used as it is as the extract, it may be in this range as a dry solid content. And if the anti-inflammatory is in this range,
When combined with the camcam extract, it does not affect the formulation and the camcam extract in the formulation, has good temporal stability, and can exhibit a high anti-inflammatory effect.
The anti-inflammatory agent can be used alone or in combination of two or more.

The external preparation for skin of the present invention can be prepared according to a conventional method, using essential components (A) and (B) in various forms known as ordinary external compositions.

Examples of the form of the external preparation for skin are not particularly limited, and include, for example, skin care cosmetics such as milky lotions, creams, lotions, packs, cleaning agents, makeup cosmetics such as lipsticks and foundations, and hair cosmetics. Cosmetics, ointments, dispersions, and pharmaceuticals such as liquids for external use can be used, and there is no particular limitation on the form of the preparations. Solid, paste, mousse, gel, powder, solution, It can be a solubilizing system, an emulsifying system, a powder dispersion system, or a multilayer.

In addition to the components (A) and (B), the external preparation for skin of the present invention usually contains cosmetics, quasi-drugs, and external medicines as long as the effects of the present invention are not impaired. Ingredients used in the formulation, namely water (purified water, hot spring water,
Oils, surfactants, metal soaps, gelling agents, powders, alcohols, water-soluble polymers, film-forming agents,
Resins, UV protective agents, clathrate compounds, antibacterial agents, fragrances, deodorants, salts, PH regulators, cooling agents, extracts from animals and microorganisms, plant extracts, blood circulation promoters, astringents, antiseborrheic agents , Active oxygen scavenger, cell activator, humectant, keratolytic agent, enzyme,
Hormones, vitamins and the like can be added. Specific examples of suitable components include those shown below. The “derivatives” of the various components exemplified below also include salts that can be formed.

The oil may be a natural oil or a synthetic oil, as long as it is used in ordinary cosmetics to improve the constituent components of the base or the usability and usability. Alternatively, irrespective of properties such as solid, semi-solid, and liquid, hydrocarbons, waxes, fatty acids, higher alcohols, ester oils, silicone oils, fluorine-based oils, and the like can be used. . For example, squalane, squalene, ceresin, paraffin, paraffin wax, liquid paraffin, pristane, polyisobutylene, microcrystalline wax, hydrocarbons such as petrolatum, beeswax, carnauba wax, candelilla wax, wax such as whale wax, tallow, cow Leg fat, beef bone fat, hardened tallow, hardened oil, turtle oil, animal oils such as lard, horse fat, mink oil, liver oil, egg yolk oil, lanolin, liquid lanolin, reduced lanolin, lanolin alcohol, hard lanolin, lanolin acetate, Lanolin fatty acid isopropyl, POE lanolin alcohol ether, POE lanolin alcohol acetate, lanolin fatty acid polyethylene glycol, lanolin derivatives such as POE hydrogenated lanolin alcohol ether, lauric acid,
Myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, oleic acid, arachidonic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (D
HA), fatty acids such as isostearic acid, 12-hydroxystearic acid, lauryl alcohol, myristyl alcohol, palmityl alcohol, stearyl alcohol, behenyl alcohol, hexadecyl alcohol, oleyl alcohol, isostearyl alcohol, hexyldecanol, octyldodecanol, Higher alcohols such as cetostearyl alcohol, 2-decyltetradecinol, cholesterol, phytosterol, sitosterol, lanosterol, POE cholesterol ether, monostearyl glycerin ether (bacyl alcohol), diisobutyl adipate, and adipic acid-2-
Hexyldecyl, di-2-heptylundecyl adipate, N-alkyl glycol monoisostearate, isosetyl isostearate, trimethylolpropane triisostearate, ethylene glycol di-2-ethylhexanoate, cetyl 2-ethylhexanoate Trimethylolpropane tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, cetyl octanoate, octyldodecyl gum ester, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate, 2-ethylhexyl succinate, isocetyl stearate, butyl stearate, diisopropyl sebacate,
Di-2-ethylhexyl sebacate, cetyl lactate, myristyl lactate, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, cholesteryl 12-hydroxystearate, dipentaerythritol Fatty acid esters, isopropyl myristate, octyldodecyl myristate, 2-hexyldecyl myristate, myristyl myristate, hexyldecyl dimethyloctanoate, ethyl laurate, hexyl laurate, N-lauroyl-L-octyldodecyl glutamate Ester, ester oil such as diisostearyl malate, acetoglyceride, triisooctanoic acid glyceride, triisostearic acid glyceride, triisopalmitic acid Riseraido, tri-2-ethylhexanoic acid glyceride, tristearate glyceride,
Glyceride oils such as tri-2-heptylundecanoic acid glyceride and trimyristate glyceride, dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane Oils, such as silicone oils such as styrene, tetramethyltetrahydrogencyclotetrasiloxane, higher alkoxy-modified silicones, higher fatty acid-modified silicones, silicone resins, silicone rubbers, silicone resins, perfluoropolyethers, perfluorodecane, and perfluorooctane And the like.

Surfactants are used for emulsifying and solubilizing oils and the like, and anionic, cationic, nonionic and amphoteric surfactants can be used.

The metal soap and the gelling agent are used for stabilizing the system, improving the usability, and improving the usability. Metal soaps include aluminum 12-hydroxystearate, zinc stearate, aluminum stearate, calcium stearate, magnesium stearate, zinc myristate, magnesium myristate, zinc cetyl phosphate, calcium cetyl phosphate, zinc sodium cetyl phosphate, zinc laurate And zinc undecylenate.

As the gelling agent, N-lauroyl-L-
Amino acid derivatives such as glutamic acid and α, γ-di-n-butylamine; dextrin fatty acid esters such as dextrin palmitate, dextrin stearate, dextrin 2-ethylhexanoate palmitate, sucrose palmitate, and sucrose stearin Sucrose fatty acid esters such as acid esters; benzylidene derivatives of sorbitol such as monobenzylidene sorbitol and dibenzylidene sorbitol; and organically modified clay minerals such as dimethylbenzyl dodecyl ammonium montmorillonite clay and dimethyl dioctadecyl ammonium montmorillonite clay.

The powder is used for a variety of purposes, mainly for coloring makeup cosmetics, for concealing the skin, or for improving the feeling of use. If the powder is used for ordinary cosmetics, the shape (spherical, acicular, etc.) is used. , Plate-like, etc.), particle diameter (fume-like, fine particles, pigment grade, etc.) and particle structure (porous, non-porous, etc.), any of which can be used. Examples include magnesium oxide, barium sulfate, calcium sulfate, magnesium sulfate, calcium carbonate, magnesium carbonate, talc, synthetic mica, mica,
Kaolin, sericite, muscovite, synthetic mica, phlogopite, mica, biotite, lithia mica, silicic acid, silicic anhydride, aluminum silicate, magnesium silicate, aluminum magnesium silicate, aluminum sulfate silicate, silica Organic powders such as calcium silicate, barium silicate, strontium silicate, metal tungstate, hydroxyapatite, vermiculite, heidilite, montmorillonite, zeolite, ceramic powder, dicalcium phosphate, alumina, aluminum hydroxide, boron nitride, etc. , Polyamide powder, polyester powder, polyethylene powder, polypropylene powder,
Polystyrene powder, polyurethane, benzoguanamine powder, polymethylbenzoguanamine powder, tetrafluoroethylene powder, polymethyl methacrylate powder, silk powder, nylon powder, 1
2 nylon, 6 nylon, styrene / acrylic acid copolymer, divinylbenzene / styrene copolymer, vinyl resin, urea resin, phenol resin, fluororesin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, fine resin Crystal fiber powder, lauroyl lysine and the like, and as the colored pigment, iron oxide, iron hydroxide,
Inorganic red pigments of iron titanate, inorganic brown pigments such as γ-iron oxide, yellow iron oxide, inorganic yellow pigments such as loess, black iron oxide,
Inorganic black pigments such as carbon black, inorganic purple pigments such as manganese violet and cobalt violet, inorganic green pigments such as chromium hydroxide, chromium oxide, cobalt oxide, and cobalt titanate; inorganic blue pigments such as dark blue and ultramarine blue; and tar pigments Laked pigments, laked natural pigments, and pearl pigments include titanium oxide-coated mica, titanium oxide-coated mica, bismuth oxychloride,
Metal powder pigments, such as titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, fish scale foil, titanium oxide-coated colored mica, and the like, aluminum powder, copper powder, stainless powder, and the like, and other natural pigments such as carmine Can be These powders may be compounded, or may be surface-treated with an oil agent, silicone, or a fluorine compound.

UV protection agents protect skin from ultraviolet rays and are useful when used in combination with anti-inflammatory agents. Examples thereof include 2-ethylhexyl paramethoxycinnamate, isopropyl paramethoxycinnamate, and paramethoxyhydrocinnamate. Cinnamic acid ultraviolet absorbers such as diethanolamine salt, glyceryl diparamethoxycinnamate-mono-2-ethylhexanoate, octyl methoxycinnamate and methyl diisopropylcinnamate, 2-phenylbenzimidazole-5
Sulfonic acid, 2-hydroxy-4-methoxybenzophenone, 2-hydroxy-4-methoxybenzophenone-
5-sulfuric acid, 2-hydroxy-4-methoxybenzophenone-5-sodium sulfate, 2,4-dihydroxybenzophenone, 2,2′-dihydroxy-4,4′-dimethoxybenzophenone, 2,2′-dihydroxy-4-methoxy Benzophenone ultraviolet absorbers such as benzophenone, 2,2 ', 4,4'-tetrahydroxybenzophenone, 2-hydroxy-4-n-octoxybenzophenone, para-aminobenzoic acid, ethyl para-aminobenzoate, butyl para-aminobenzoate, para-butyl benzoate Benzoic acid ultraviolet absorbers such as dimethylaminobenzoic acid-2-ethylhexyl, paraaminobenzoic acid glyceryl, and paraaminobenzoic acid amyl, salicylic acid-2-ethylhexyl, salicylic acid triethanolamine, homomenthyl salicylate, dipropylene glycol salicylate Lumpur, methyl salicylate,
Ethylene glycol salicylate, phenyl salicylate,
Salicylic acid ultraviolet absorbers such as amyl salicylate, benzyl salicylate, isopropylbenzyl salicylate, and potassium salicylate, 4-t-butyl-4′-methoxydibenzoylmethane, 4-isopropyldibenzoylmethane, 4-methoxydibenzoylmethane, 4-methoxydibenzoylmethane dibenzoylmethane-based ultraviolet absorbers such as t-butyl-4'-hydroxydibenzoylmethane, menthyl-O-aminobenzoate, 2-phenyl-benzimidazole-5-sulfate, 2-phenyl-5-methylbenzoxazole, 3-
(4-methylbenzylidene) camphor, 2-ethylhexyl-2-cyano-3,3'-diphenylacrylate, 2-ethyl-2-cyano-3,3'-diphenylacrylate, 2- (2'-hydroxy-5 Examples include anthranilic acid-based ultraviolet absorbers such as methylphenyl) benzotriazole and menthyl anthranilate, urocanic acid-based ultraviolet absorbers such as ethyl urocanate, titanium oxide, zirconium oxide, and cerium oxide.

Specific examples of the water-soluble polymer used for stabilizing the system, improving the usability and usability, and for obtaining the moisturizing effect include gum arabic, tragacanth, galactan, and guar gum. Plant-based polymers such as karaya gum, carrageenan, pectin, agar, trant gum, locust bean gum, galactomannan, microbial polymers such as xanthan gum, dextran, succinoglucan, animal polymers such as casein, albumin, and gelatin; Starch, carboxymethyl starch, starch-based polymers such as methylhydroxypropyl starch, methylcellulose, ethylcellulose, methylhydroxypropylcellulose, carboxymethylcellulose, hydroxymethylcellulose, hydroxypropylcellulose, nitrocell Over vinegar, sodium cellulose sulfate,
Sodium carboxymethylcellulose, crystalline cellulose, cellulosic polymer of cellulose powder, sodium alginate, alginic acid polymers such as propylene glycol alginate, polyvinyl polymers such as polyvinyl methyl ether, carboxyvinyl polymer, alkyl-modified carboxyvinyl polymer, poly Oxyethylene polymers, polyoxyethylene polyoxypropylene copolymer polymers, acrylic polymers such as sodium polyacrylate, polyethyl acrylate, polyacrylamide, polyethylene imine, cationic polymers, bentonite, laponite, hectorite, etc. There are inorganic water-soluble polymers and the like. In addition, film-forming agents such as polyvinyl alcohol and polyvinyl pyrrolidone are also included in these.

Cell activators are used for the purpose of improving skin roughness and the like. Mucopolysaccharides such as dermatan sulfate, heparan sulfate, heparin and keratan sulfate or derivatives thereof, collagen, eicosapentaenoic acid and derivatives thereof, estradiol, ethynyl Estradiol, glycolic acid, citric acid, lactic acid, malic acid, tartaric acid, succinic acid,
Organic acids such as salicylic acid and derivatives thereof, deoxyribonucleic acid and derivatives thereof, adenosine triphosphate, adenosine diphosphate, adenylic acid derivatives such as adenosine monophosphate, ribonucleic acid and derivatives thereof, cyclic AMP, cyclic GMP, Flavin adenine dinucleotide,
Guanine, adenine, cytosine, thymine, xanthine,
Caffeine and its derivatives, theophylline and its derivatives, calf blood extract, serum deproteinized extract, spleen extract,
Egg ingredients such as birds, cockscomb extract, shell extract, shellfish extract, royal jelly, silk protein and its degradation products or their derivatives, hemoglobin or its degradation products, lactoferrin or its degradation products, mollusc extracts such as cuttlefish , Fish meat extract, asparagus extract, apricot extract,
Ginkgo extract, panax ginseng extract, barley extract, orange extract, cucumber extract, shiitake extract, horsetail extract, assembly extract, daisy extract,
Capsicum extract, garlic extract, carrot extract,
Examples include boukuroyou extract, peach extract, lettuce extract, lemon extract, lily extract, rosemary extract, hinokitiol, cepharanthin, grape seed oil and the like.

Examples of whitening agents include endothelin antagonists, glutathione and its derivatives, cysteine and its derivatives such as N, N'-diacetylcystine dimethyl, resorcin and its derivatives, hydroquinone and its derivatives, glabridine, glabrene, liquiritin, isoliquiritin, Astaxanthin, carotenoids such as lutein, neo-agarobiose, agarose oligosaccharide, pea extract, oedum extract, pentagon extract, ononis extract, seaweed extract, raspberry extract, kujin extract, keikei extract, Coffee extract, kokahi extract, wheat germ extract, vegetable oil containing linoleic acid such as sesame and perilla, saicin extract, hawthorn extract, sampens extract, shirayuri extract, peonies extract, sempukuka extract Digest, soy extract, green tea, black tea,
Tea extract such as oolong tea, molasses extract, tomato extract, syrup extract, beech bud extract, grape extract, flow de manita extract, hop extract, maikaika extract, mocca extract, saxifrage extract , Yokuinin extract and arhat extract.

The active oxygen scavenger is used for the purpose of suppressing lipid peroxide and the like, and includes superoxide dismutase,
Mannitol, beta-carotene, bilirubin, tryptophan, histidine, quercetin, quercitrin,
Catechin and its derivatives, rutin and its derivatives, taurine, thiotaurine, eggshell membrane extract, gallic and its derivatives, yeast extract, ganoderma extract, yasajitsu extract, genoshoko extract, buttonpi extract, melissa extract, parsley Extracts, dicoppi extracts, retinol and its derivatives (retinol palmitate, retinol acetate, etc.), retinal and its derivatives, dehydroretinal, carotenoids such as carotene and other vitamins A, thiamines (thiamine hydrochloride, thiamine sulfate) , Riboflavins (riboflavin, riboflavin acetate, etc.), pyridoxines (pyridoxine hydrochloride, pyridoxine dioctanoate, etc.), cyanocobalamins, folic acids, nicotinic acids (nicotinamide, benzyl nicotinate, etc.), and vitamin Bs such as choline , Vitamin C, such as Corvin acid
, Ergocalciferol, cholecalciferol,
Vitamin Ds such as dihydroxystannal, tocopherol and derivatives thereof (dl-α (β, γ) -tocopherol, dl-α-tocopherol acetate, nicotinic acid-d
l-α-tocopherol, linoleic acid-dl-α-tocopherol, dl-α-tocopherol succinate, etc.), vitamin Es such as ubiquinones, dibutylhydroxytoluene and butylhydroxyanisole.

Examples of the humectant include proteins such as elastin, fibronectin and keratin, derivatives thereof, hydrolysates and salts thereof, glycine, alanine, valine, isoleucine, serine, threonine, aspartic acid, glutamic acid, asparagine, glutamine, and the like. Amino acids such as lysine, hydroxylysine, arginine, cystine, methionine, phenylalanine, tyrosine, proline, theanine, hydroxyproline, ortinine, and citrulline and derivatives thereof, sorbitol, erythritol, maltitol, xylitol, xylose, trehalose, inositol, glucose,
Pentaerythritol, fructose, sucrose and its esters, dextrin and its derivatives, sugars such as honey,
D-panthenol and its derivatives, urea, phospholipid, glycolipid, ceramide, avocado extract, almond extract,
Carob extract, rice extract, strawberry extract, fennel extract, russia oil extract, spinach extract,
Olive oil, edible soybean extract, cacao butter, oats extract, kizuta extract, kumazasa extract, gardenia extract, grapefruit extract, burdock extract, kobotdul extract, cactus extract, saponosa extract, ginger extract, shobu Extract, Jiao extract, Shea butter, Spiraea extract, Stevia extract, Senkyu extract, Zeniaoi extract, Tachijakoso extract, Camellia extract, Maize extract, Eucommia extract, Tormentilla extract, Dokudami extract , Bacmondou extract, Gourd extract, Hamamelis extract, Mentha extract, Green peppermint extract, Common peppermint extract, Rose extract, Sunflower extract, Cypress extract, Dandelion extract, Prune extract, Butchers bloom extract , Safflower extraction , Borage oil, jojoba oil, bodaige extract, pine extract, maroni extract, macadamia nut oil, quince extract, purple extract, meadow home oil, cornflower extract, yuzu extract, lime extract, lavender extract, Gentian extract, apple extract and the like.

As blood circulation promoters, nonylate valenylamide, capsaicin, zingerone, canthari tincture,
Ictamol, α-borneol, inositol hexanicotinate, cyclanderate, cinnarizine, tolazoline, acetylcholine, verapamil, γ-oryzanol and the like.

Tanninic acid and the like as skin astringents, thiantrol and the like as antiseborrheic agents, lipase as enzymes and
Papain and the like.

[0031]

EXAMPLES Next, the present invention will be described in more detail with reference to Reference Examples, Test Examples, Examples and Comparative Examples, but the present invention is not limited thereto.

REFERENCE EXAMPLE 1 Production of cam cam extract Cam cam (Myrcilia, a fruit tree belonging to the family Myrtaceae)
100 ml of 80% (v / v) water-containing ethyl alcohol was added to 30 g of dried Dubia) fruit, extracted at room temperature for 3 days, and filtered to obtain a cam cam extract. (Dry solid content 3.0%)

Reference Example 2 Production of chamomile extract 20 g of dried chamomile flowers were minced, 100 ml of 1,3-butylene glycol was added, the mixture was extracted for 5 days at room temperature with occasional stirring, and filtered to remove the chamomile extract. Obtained. (Dry solid content 0.9%)

Test Example 1 Erythema Inhibition Test and Pigmentation Inhibition Test The backs of colored guinea pigs (15 per group) were shaved and irradiated with ultraviolet light under anesthesia. UV irradiation is performed by FL2 manufactured by Toshiba Corporation.
Irradiate three 0S • BLB lamps and three FL20S • E30 lamps at the same time, and the amount of ultraviolet rays is 4.8 × 10 ⁶ erg /
cm ² . Twenty-four hours before ultraviolet irradiation, immediately after irradiation, and 12 hours after and 24 hours after irradiation, 0.2 ml each of the composition shown in Table 1 and a sample prepared by the following method were applied to four places on the back of the guinea pig. However, before irradiation, the application site was thoroughly washed with warm water. 24 hours after irradiation,
After 7 days, the degree of pigmentation was observed and evaluated according to the following criteria. The results are also shown in Table 1.

(Composition and results)

Table 1 Examples 1 and 2 and Comparative Examples 1 to 4

(Production method) A. Components (1)-(6), (8) and (10) are mixed and heated to 70 ° C. B. Ingredient (12) is mixed and heated to 70 ° C. C. Add B to A, mix and cool, (7)
(9) and (11) were added and uniformly mixed to obtain a cream.

(Evaluation Criteria for Erythema Inhibition Effect) <Evaluation> <Contents> Excellent Erythema is not observed at all. Effective Very little erythema is observed. Slightly effective Erythema is observed, but the boundary with the non-irradiated part is unclear. Ineffective Erythema was observed, and the boundary with the non-irradiated part was clear.

(Evaluation Criteria for Pigmentation Inhibition Effect) <Evaluation> <Contents> Excellent Effect No pigmentation was observed at all. Effective Very slight pigmentation is observed. Slightly effective pigmentation is observed, but the boundary with the non-irradiated part is unclear. Ineffective Pigmentation was observed, and the boundary with the non-irradiated part was clear.

As shown in the results of Table 1, the composition of the present invention obtained by combining the camcam extract represented in Example 1 with stearyl glycyrrhetinate and the camcam extract and chamomile extract represented in Example 2 were used. It has been found that the combined compositions of the present invention, when applied to the skin, effectively suppress erythema formation and subsequent pigmentation by ultraviolet light.

[0040]

(Production method) Components (1) to (4), (8) and (9) are mixed and dissolved. B. Components (5), (6), (7) and (10) are mixed and dissolved. C. A and B were mixed and made uniform to obtain a lotion.

[0042]

(Production method) The components (11) to (14) are mixed by heating and kept at 70 ° C. B. Components (1) to (6) and (10) are mixed by heating.
Keep at 0 ° C. C. Add A to B, mix and emulsify uniformly. D. After cooling C, (7), (8), (9) and (15) were added and mixed uniformly to obtain an emulsion.

Embodiment 5 FIG. Ointment (Formulation) (%) (1) Stearic acid 18.0 (2) Cetanol 4.0 (3) Triethanolamine 2.0 (4) Glycerin 5.0 (5) Camcam extract * 1 1.0 ( 6) Licorice extract * 2 1.0 (7) Guaiazulene * 3 0.1 (8) Remaining amount of purified water * 1 Produced in Reference Example 1 * 2 Maruzen Pharmaceutical * 3 Sigma

(Production method) A part of components (3), (4) and (8) are mixed by heating and kept at 75 ° C. B. Heat mix components (1) and (2) and maintain at 75 ° C. C. Add A slowly to B. D. C was dissolved in the remainder of (8) while cooling (5),
(6) and (7) were added to obtain an ointment.

Examples 3 to 5 were excellent in stability over time and, when applied to the skin, calmed hot flashes due to sunburn and effectively suppressed pigmentation.

Embodiment 6 FIG. Pack (Formulation) (%) (1) Polyvinyl alcohol 20.0 (2) Ethyl alcohol 20.0 (3) Glycerin 5.0 (4) Kaolin 6.0 (5) Camcam extract * 1 0.05 (6) ) Comfrey extract * 2 0.2 (7) Preservative 0.2 (8) Perfume 0.1 (9) Purified water Remaining * 1 Produced in Reference Example 1 * 2 Ichimaru Falcos

(Production method) A. Mixing components (1), (3), (4) and (9),
Heat to 70 ° C. and stir. B. Mix components (2), (7) and (8). C. B is added to A, mixed and cooled (5),
(6) was uniformly dispersed to obtain a pack.

Example 6 was a pack which was excellent in stability over time and applied to the skin to calm down hot flashes.

Embodiment 7 FIG. Detergent (Prescription) (%) (1) Stearic acid 10.0 (2) Palmitic acid 8.0 (3) Myristic acid 12.0 (4) Lauric acid 4.0 (5) Oleyl alcohol 1.5 (6) ) Purified lanolin 1.0 (7) Fragrance 0.1 (8) Preservative 0.2 (9) Glycerin 18.0 (10) Potassium hydroxide 6.0 (11) Camcam extract * 1 0.5 (12) ) Gentian extract * 2 0.01 (13) Perilla extract * 3 0.5 (14) Remaining purified water * 1 Produced in Reference Example 1 * 2 Maruzen Pharmaceutical * 3 Maruzen Pharmaceutical

(Production method) Mix components (9), (10) and (14) and mix
Heat to ° C. B. Mix components (1)-(6) and (8) and heat to 70 ° C. C. B was added to A, mixed, cooled to 50 ° C., and components (7), (11) and (12), (13) were added, and the mixture was cooled to obtain a cleaning agent.

Example 7 was a cleaning agent which was excellent in stability over time and suppressed hot flashes when applied to the skin.

Embodiment 8 FIG. Gel ointment (Formulation) (%) (1) Carboxyvinyl polymer 1.0 (2) Triethanolamine 1.0 (3) 1,3-butylene glycol 10.0 (4) Camcam extract * 1 0.01 ( 5) Allantoin * 2 0.02 (6) Remaining purified water * 1 Manufactured in Reference Example 1 * 2 Merck

(Production method) Components (1) and (3) to (6) are mixed and dissolved. B. Component (2) was added to A and mixed to make a uniform, and a gel ointment was obtained.

The gel ointment of Example 8 has excellent stability over time,
By applying to the skin, erythema due to sunburn was suppressed, and pigmentation was effectively prevented.

[0056]

(Production method) A. Components (1) to (6) are mixed and dissolved. B. Add the components (11) to (13) and (15) to A and mix them uniformly. C. Components (7) to (10) are uniformly dissolved and kept at 70 ° C. D. Add C to B and emulsify uniformly. E. FIG. After cooling D, components (14) and (16) were added to obtain a liquid foundation.

Example 9 was a liquid foundation which was excellent in stability over time and applied to the skin to prevent darkening of the skin due to sunburn, spots and freckles.

[0059]

As described above, the inherent performance of the anti-inflammatory agent can be fully exhibited by including the camcam extract and the anti-inflammatory agent. That is, since it has a stable and excellent anti-inflammatory action, it is effective in suppressing hot flashes due to sunburn and erythema due to ultraviolet irradiation and suppressing pigmentation. Therefore, the composition of the present invention can sufficiently exhibit the inherent performance of an anti-inflammatory agent, and is extremely useful in beauty and medicine.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI Theme coat ゛ (Reference) A61K 35/78 A61K 35/78 V 4C206 7/00 7/00 BCCD KU 7/42 7/42 7/48 7/48 31/015 31/015 31/19 31/19 31/192 31/192 31/195 31/195 31/196 31/196 31/405 31/405 31/415 31/415 31 / 4166 31/4166 31/56 31/56 31/737 31/737 33/04 33/04 33/30 33/30 45/00 45/00 A61P 17/06 A61P 17/06 29/00 29/00 C07H 15 / 256 C07H 15/256 A // A61K 7/50 A61K 7/50 F term (Reference) 4C057 BB03 DD01 JJ54 4C083 AA031 AA082 AA111 AA112 AB032 AB111 AB211 AB432 AB442 AC022 AC072 AC102 AC122 AC172 AC212 AC242 AC342 AC551 AC542 AC542 AC681 AC682 AC812 AC851 AD092 AD112 AD272 AD341 AD512 AD531 AD532 BB51 CC02 CC04 CC05 CC07 CC12 CC23 DD22 DD23 DD31 DD41 EE12 FF01 4C084 AA17 MA63 NA14 ZA892 ZB112 4C086 AA01 AA02 BC13 BC36 BC38 DA08 MA63 NA14 ZA89 ZB11 4C088 AB12 AB13 AB25 AB26 AB29 AB38 AB40 AB41 AB57 AB59 AB60 AB62 AB67 AB81 AB86 AB99 BA09 BA10 CA03 MA08 MA09 MA63 NA14 ZA89 ZB11 DA02 FA09 MA04 MA83 NA14 ZA89 ZB11

Claims (6)

[Claims] 1. An external preparation for skin, comprising the following components (A) and (B): (A) a camcam extract; and (B) an anti-inflammatory agent. 2. An anti-inflammatory agent comprising zinc oxide, sulfur and its derivatives, glycyrrhizic acid and its derivatives, glycyrrhetinic acid and its derivatives, tranexamic acid and its derivatives, chondroitin sulfate and its derivatives, mefenamic acid and its derivatives, allantoin and 2. The external preparation for skin according to claim 1, which is selected from a derivative thereof, guaiazulene and derivatives thereof, phenylbutazone, indomethacin, ibuprofen, ketoprofen, ε-aminocaproic acid, and diclofenac sodium. 3. The content of the anti-inflammatory agent is 0.0001-5.
3. The external preparation for skin according to claim 2, which is contained in a weight%. 4. An anti-inflammatory agent comprising an aloe extract, an Altea extract, an Ashitaba extract, an Arnica extract, a clam extract, a nettle extract, a turmeric extract, a syrup extract, a hypericum extract, a chamomile extract, Licorice extract, Kingfisher extract, Watercress extract, Comfrey extract, Salvia extract, Shikon extract, Perilla extract,
The extract is selected from a birch extract, a calendula extract, an elder extract, an asparagus extract, a sage extract, a botanical extract, a mugwort extract, a gentian extract, a licorice extract and a eucalyptus extract. The topical skin preparation according to the above. 5. The method according to claim 1, wherein the content of the anti-inflammatory agent is a dry solid content.
The external preparation for skin according to claim 4, which is 0.0001 to 5% by weight. 6. The skin external preparation according to any one of claims 1 to 5, wherein the content of the camcam extract is 0.0001 to 5% by weight as a dry solid content.