JP2000281144A - Packaging body - Google Patents

Abstract

PROBLEM TO BE SOLVED: To manufacture a packaging body bringing an instrument into contact with a liquid simply and sterilely and preventing the dissipation of odor to the outside, pollution, infection and the like after the use of the instrument. SOLUTION: A packing material 2 for a packaging body 1 is manufactured by being fusion bonded with a sheet material, and a first space 4 and a second space 5 parted by a partition 22 are formed therein. A weak sealing section 23 is formed on the partition 22. A catheter 7 and a deodorizing agent 8 stored in a container 81 provided with breathability are stored in the first space 4. A fluid substance 10 is stored in the second space 5. When the seal sealing section 23 is peeled off and the fluid substance 10 is made to flow into the first space 4 and brought into contact with the catheter 7, the surface of the catheter 7 is wetted to reduce the friction resistance.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a package for packaging a device such as a catheter.

[0002]

2. Description of the Related Art Catheters to be inserted into trachea, digestive tract, urethra, blood vessels, other body cavities, various organs, living tissues, etc.
On the surface of a medical device such as a guide wire inserted into the catheter, a large number of thrombus, tissue adhesion or foreign body reaction is generally confirmed. Therefore, it is necessary to reduce the damage to the living tissue and securely insert it into the target site. Further, in order to suppress mucosal inflammation and mucosal damage during indwelling in a living tissue, it is necessary to impart lubricity to the device surface.

For this reason, a low friction material is used as a base material, or water, a physiologically isotonic liquid or a lubricant is applied to the surface of the device prior to use. To elaborate,
The base material of the catheter has a multilayer laminated structure, and the outermost layer (or innermost layer) is made of a low friction material such as fluororesin or polyethylene resin, and the surface of the device is lubricated with water, physiological isotonic solution, glycerin, oil, etc. Agent is applied.

However, in selecting the material of the catheter base material, there is a limit in improving the slidability, and it is difficult to reach a satisfactory level.

[0005] Further, when a lubricant or the like is applied, if the product is to be commercialized while being brought into contact with the medical device, the lubricant may be used for a long time before the medical device is used. There is concern about deterioration, deterioration, peeling off from the surface of the medical device, etc., and there have been problems in terms of stability (preservability) and associated safety.

Further, it is very difficult to aseptically contact a medical device and a lubricant during use, and there is a problem that bacterial infection or the like may occur.

In an emergency, since maintaining the life of the patient is the highest priority, the operation of applying the lubricant becomes troublesome. In some cases, the lubricant is not applied and the surface is kept dry. May be used in

[0008] As a method for causing a compound which exhibits lubricity when wetted on the surface of a medical device to be present, an international application WO 9
In 001344, at least one of an alkali metal alcoholate, an amino group, an alkali metal amide group, a carboxylic acid group, a sulfonic acid group, a magnesium halide group and a fluorine-boron complex group is introduced into the polyurethane surface by a coating operation. By operation,
A technique for immobilizing a hydrophilic polymer that can react with these functional groups on the surface is disclosed.

[0009] Similarly, a method of causing a compound which exhibits lubricity when wetted on the surface of a medical device to be present is disclosed in Japanese Patent Publication No. 6-32652, Japanese Patent Application Laid-Open No. 6-7426, International Application WO9219289, Japanese Patent Application Publication No. -502854, Tokiohei 10-502855, Tokiohei 10-502856
No., etc. are also disclosed.

[0010] However, in these methods, lubricating properties are not exhibited by drying, and the medical device is taken out of the packaging material at the time of use, and a liquid such as water or a physiologically isotonic solution is put on the surface of the medical device. The operation of supplying and contacting is essential. Moreover, it is very difficult to perform this operation aseptically, except when using special operations or facilities.
For this reason, as described above, there is a risk of infection, and in an emergency, it may be inserted directly into the trachea, digestive tract, urethra, blood vessels, etc. in a dry state, and there is concern that mucous membranes may be damaged. Was to be done.

On the other hand, when blood comes in contact with foreign substances other than vascular endothelial cells, adhesion of plasma proteins and platelets and blood coagulation are induced on the surface of the foreign substances, and thrombus is formed. This thrombus formation becomes a problem when using medical devices such as catheters and guide wires.

For this reason, blood anticoagulants such as heparin are administered to blood, or blood anticoagulants are applied to the surface of medical instruments, or antithrombotic materials are used as base materials. Have been done.

[0013] However, in the former case, harmful effects such as bleeding tendency are caused to the patient, and in the latter case, a contact operation with a liquid is required at the time of use. , As described above, in that it is very difficult.

Further, in an emergency, since maintaining the life of the patient is the highest priority, the patient may be directly used without performing an anticoagulant operation, and there is a concern that there may be an adverse effect due to thrombus formation.

After use of these medical instruments, they are discarded as medical waste. Usually, inactivation operations (disinfection / sterilization operations) of bacteria, viruses and the like in body fluids and blood are performed.
It was discarded without infective or deodorizing operations, while remaining infectious or allowing odor release.

[0016] For this reason, after the medical device is used and before it is incinerated, the odor may be radiated or body fluids such as urine and blood may leak out, resulting in contamination or infection of the surroundings.

[0017]

SUMMARY OF THE INVENTION The present invention has been made in view of the above-mentioned problems, and an object of the present invention is to enable simple and aseptic contact between an instrument and a liquid, and to use the instrument. It is another object of the present invention to provide a package capable of preventing the emission of odor to the outside, contamination, infection and the like.

[0018]

This and other objects are achieved by the present invention which is defined below as (1) to (15).

(1) A packaging material having a first space and a second space which are separated from each other by a partition portion and can communicate with each other when necessary, and are stored in the first space and inserted or attached to a living body for use. A device that is stored in the first space and eliminates or reduces odor, and a flow that is stored in the second space and can contact the surface of the device and reduce its frictional resistance. A package comprising: a conductive substance.

(2) The package according to the above (1), wherein the main component of the substance that extinguishes or reduces the odor is titanium oxide.

(3) A packaging material having a first space and a second space which are separated from each other by a partition portion and can communicate with each other when necessary, and are stored in the first space and inserted or attached to a living body for use. A device that is stored in the first space and has a function of suppressing at least the growth of microorganisms; and a device that is stored in the second space and contacts the surface of the device to reduce its frictional resistance. And a flowable substance.

(4) The package according to (3), wherein the main component of the substance having a function of suppressing the growth of microorganisms is titanium oxide.

(5) A packaging material having a first space, a second space, and a third space which are separated from each other by a partition portion and can communicate with each other when necessary, and are housed in the first space and inserted into a living body. Or a device to be mounted and used, a fluid substance stored in the second space, which can be brought into contact with the surface of the device to reduce its frictional resistance, and a fluid material stored in the third space, A substance capable of absorbing and retaining a liquid.

(6) A packaging material having a first space, a second space, and a third space which are separated from each other by a partition portion and can communicate with each other when necessary, and a packaging material which is housed in the first space and inserted into a living body. Alternatively, it is characterized by comprising a device to be worn and used, a blood anticoagulant stored in the second space, and a substance stored in the third space and capable of absorbing and retaining a liquid. Packaging.

(7) The above (5), wherein the first space and the second space are formed adjacent to each other, and the first space and the third space are formed adjacent to each other. ) Or the package according to (6).

(8) The package according to any one of (1) to (7), wherein the second space is formed inside the first space.

(9) The package according to any one of the above (1) to (8), wherein the partition portion is constituted by a seal portion formed by fusing a sheet material constituting the packaging material.

(10) The package according to any one of the above (1) to (9), wherein at least a part of the partition portion is constituted by a weak seal portion having a lower joint strength than other portions.

(11) The above-mentioned (1) to (1), further comprising an opening portion for taking out the device from the first space, and sealing means for sealing the opening after opening the opening portion.
0) The package according to any one of the above.

(12) The package according to any one of the above (1) to (11), wherein the packaging material has a steam barrier property.

(13) The package according to any one of (1) to (12), wherein the device is a catheter or a guide wire.

(14) The package according to any one of (1) to (12) above, wherein the device is a catheter used by being inserted into the urethra.

(15) The package according to any one of the above (1) to (14), wherein a compound that develops lubricity by wetting is provided on at least a part of the surface of the device.

[0034]

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, a package according to the present invention will be described in detail based on preferred embodiments shown in the accompanying drawings.

FIG. 1 is a plan view (an internal perspective view) showing a first embodiment of the package of the present invention. As shown in FIG. 1, a package 1 includes a packaging material 2 having a first space and a second space.
have.

The packaging material 2 is a bag-like material obtained by sealing a sheet material as described later in a desired pattern by fusing (or bonding). A band-shaped seal portion 21 is formed on the outer peripheral portion of the packaging material 2 and the like.

A partition 22 is formed in the middle of the packaging material 2. The partition 22 is formed by fusing (or adhering) a sheet material in a band shape similarly to the seal portion 21. The partition 22 divides the inside of the packaging material 2 into a first space 4 and a second space 5 (isolated from each other).

As shown by hatching in FIG.
A part of 2 is composed of a weak seal part (easy peel seal part) 23 having lower bonding strength (peeling strength) than the other part (seal part 21). By peeling (breaking) the weak seal portion 23, the first space 4 and the second space 5 are separated.
Communicates with

The sealing portion 21 has a completely joined state in which the opposing sheet materials are completely fused together, while the weak sealing portion 23 has a structure in which the opposing sheet materials are fused at a lower temperature. The state is such that the fusion between them is incomplete to some extent. However, the liquid tightness (airtightness) is ensured also in the weak seal portion 23. And the effect lasts over time.

To peel (break) the weak seal portion 23,
Pressing (pressing) a portion of the packaging material 2 that defines the second space 5
However, it becomes possible by increasing the internal pressure of the second space 5. In addition, the weak seal portion 23 may be rubbed and loosened by hand, or these methods may be used in combination. Thus, the first space 4 and the second space 5 can be communicated with each other with a very simple operation.

It should be noted that the weak seal portion 23 is connected to the partition
Or may be formed at more than
2 may be formed over almost the entirety.

The sealing portion 2 at the upper end of the packaging material 2 in FIG.
1, a weak seal portion (opening portion) 24 similar to the weak seal portion 23 is formed. The weak seal portion 24 is peeled (ruptured), the packaging material 2 is opened, and the stored items in the first space 4 can be taken in and out.

A zipper (sealing means) 3 which can be opened and closed is provided near the upper end side of the weak seal portion 24 in FIG. Even after the weak seal portion 24 has been peeled (ruptured) and the packaging material 2 has been opened, the zipper 3 can be closed to seal the opening. When the zipper 3 is opened, the opening can be opened again.

The zipper 3 may be of any known configuration, such as a zipper formed of grooves and projections that fit together.

The first space 4 contains a device to be inserted into or attached to a living body, and a substance for eliminating or reducing odor. A catheter or a guide wire is preferably used as an instrument to be inserted or attached to a living body. In the present embodiment, a catheter 7 and a deodorant (deodorant) 8 are housed in the first space 4. I have.

The catheter 7 is inserted into, for example, the trachea, digestive tract, urethra, vagina, blood vessels, lymph vessels, bile ducts, other body cavities, various organs such as lungs, hearts, kidneys, and other living tissues. Although various catheters and balloon catheters can be mentioned, catheters (urethral catheters, urinary catheters) used by inserting into the urethra are particularly preferable.

The urinary drainage method for dysuria is preferably an aseptic intermittent urinary drainage method instead of an indwelling catheter. In recent years, self-urinary drainage, in which a patient himself discharges urine using a catheter, has become widespread as an effective treatment method. . Urinary dysfunction is caused by obstruction of the urethra due to benign prostatic hyperplasia, stones, tumors, and neuropathic bladder caused by disorders of the brain, spinal cord, and pelvic nerves. It is necessary to drain urine regularly because the internal pressure increases and places a burden on the kidneys. The self-guided urinary method performed at this time has the advantages of completely excreting urine at low pressure, reducing existing urinary infections, relieving urinary frequency, urinary incontinence, and not burdening the bladder and kidneys. The patient inserts a catheter into the bladder through the urethra about 4 to 6 times a day, and removes the urine when the urine has been discharged. The frequency is, for example, 4
Every 5 hours, the night is before bedtime.

The surface of the catheter 7 is preferably provided with, for example, a substance which exhibits lubricity when wet. Examples of such a substance include, for example, JP-A-60-2
59269 and Japanese Patent Application Laid-Open No. 1-195863. Further, for example, Japanese Patent Publication No. 6-32652, Japanese Patent Application Laid-Open No. 6-7426,
International application WO8802623, International application WO89075
21, international application WO8909246, international application WO90
01344, International application WO9219289, International application W
O9311751, International application WO9529722, JP-T10-502854, JP-T10-502855
And the materials and methods disclosed in JP-A-10-502856. Such a substance exists on the surface of the catheter 7 in a non-wetting state (dry state).

Such a substance is a polymer chemically bonded to the surface of the base material of the catheter 7, and peeling from the surface of the base material of the catheter 7 is caused by elution into water, a physiological isotonic solution, other lubricants, or the like. Are less likely to occur from the viewpoints of lubricity continuity and safety.

As the deodorant (deodorant) 8, any of commercially available deodorants, deodorants, fragrances and the like may be used. In this case, the odor removing mechanism of the deodorant 8 also includes a physical deodorizing method (porous substances such as activated carbon and zeolite) and a chemical deodorizing method (various organic and inorganic compounds, plant extracts, ozone, noble metal-based oxidation). Catalyst), biological deodorization method (microorganisms, artificial enzymes), sensory deodorization method (aromatic compounds, vegetable oil)
For example, any device that can be stored in the first space 4 may be used.

A particularly preferred deodorizing agent 8 is titanium oxide (TiO ₂ ). This titanium oxide has the following advantages.

1) It is a harmless inorganic oxide and can be harmonized with the environment. 2) As a result of ultraviolet light excitation, it has strong oxidizing power and can decompose the adsorbed organic matter at room temperature. 3) The adsorbed oxygen is changed into oxygen radicals, and the organic substances adsorbed by the radicals can be decomposed at room temperature. 4) The effects of 2) and 3) above are caused by the illumination light of the daily living space.

Due to such excellent functions of titanium oxide, not only a deodorizing effect but also an antibacterial and antifungal effect can be obtained. Preferably, such titanium oxide is supported on a base material of organic synthetic fibers such as paper and nonwoven fabric, and fibers composed of an organic compound such as pulp.

The deodorant 8 is contained in a container (packaging material) 81 having air permeability. The container 81 is preferably made of a material that allows gas to permeate but does not allow liquid to permeate. Such a container 8
Examples of the constituent material 1 include a water-impermeable porous body such as a polyethylene nonwoven fabric and a polytetrafluoroethylene porous body.

The second space 5 contains (fills) a flowable substance (liquid or semi-liquid substance) 10 which can come into contact with the surface of the catheter 7 and reduce its frictional resistance.

Examples of the fluid substance 10 include water, physiologically isotonic solutions (physiological saline), oils such as glycerin, silicone oil and olive oil, xylocaine jelly and the like (hereinafter, these are collectively referred to as “lubricating oil”). Agent ").

In the case where the surface of the catheter 7 is provided with a substance that exhibits lubricity by wetting as described above, the fluid substance 10 may be any substance that can wet this substance. Typical examples thereof include water, physiologically isotonic solution (physiological saline), glycerin aqueous solution, and the like.

The packaging material 2 (preferably the entire packaging material 2) is
It preferably has air barrier properties. Here, the steam bath
The term “rear” means that the water vapor permeability is preferably 30 g / m 2.
^Two・ 24hrs ・ 25μm thickness ・ 40 ℃ ・ 90% RH or less
Below, more preferably 10 g / m ^Two・ 24hrs ・ 25μ
m thickness ・ 40 ℃ ・ 90% RH or less, more preferably 1g
/ M^Two・ 24hrs ・ 25μm thickness ・ 40 ℃ ・ 90% RH
Say that: This water vapor permeability is measured according to JIS
It is measured by the method described in K7129 (Method A).

As described above, since the packaging material 2 has a water vapor barrier property, evaporation of moisture from the interior of the packaging material 2, particularly from the second space 5, can be prevented. As a result, it is possible to prevent the liquid material (fluid substance 10 and the like) in the second space 5 from being reduced and concentrated, and the amount of the liquid material is required to be a minimum necessary amount. Weight can be reduced. In addition, it is possible to prevent water vapor from entering the first space 4 from the outside of the packaging material 2 or from the second space 5.

A sheet material (film) constituting the packaging material 2;
In particular, as the sheet material having the steam barrier property,
For example, polyethylene, polypropylene and other polyolefin resins, blended resins of these polyolefin resins,
Polyester resins such as polyethylene terephthalate, polyvinylidene chloride, single-layer films such as vinyl chloride-vinylidene chloride copolymer, aluminum and silica vapor-deposited on these films, aluminum films,
A metal foil such as an aluminum laminate film or a film containing a metal foil can be used. Moreover,
Those obtained by laminating two or more of these films can also be used.

In the weak seal portions 23 and 24,
The layer (sealant layer) directly involved in fusion is composed of a blend resin of two or more incompatible polyolefin resins or a random or block copolymer having two or more incompatible polyolefins in segments. Is preferred.

In the present invention, it is preferable that the entire packaging material 2 or at least a portion defining the second space 5 of the packaging material 2 is formed of a sheet material having a water vapor barrier property.
Such sheet materials include, for example, [1] a single-layer film composed of one kind of polyolefin resin, [2] a single-layer film composed of a blend resin of two or more incompatible polyolefin resins, 3] A multilayer film of a polyolefin resin or polyester resin using a polyolefin resin (a blended resin of a polyolefin resin can also be used) for the sealant layer (layer involved in fusion).

In order to obtain a higher water vapor barrier property, for example, [4] a film in which the sealant layer is composed of a polyolefin resin (a blended resin of a polyolefin resin can also be used), and a polyolefin or polyester whose outer layer is coated with polyvinylidene chloride Multilayer film composed of films, etc., [5] Sealant layer composed of polyolefin resin (blend resin of polyolefin resin can also be used), Polyolefin film or polyester film with outer layer deposited by aluminum or silica Multilayer film.

Further, in order to obtain an extremely high water vapor barrier property, for example, [6] the sealant layer is made of a polyolefin resin (a blended resin of a polyolefin resin can also be used).
A multilayer film composed of an aluminum film as the intermediate layer and a polyester film as the outermost layer. In this case, one of the pair of sheet materials facing each other is an opaque aluminum film,
The other is preferably a transparent water vapor barrier film such as a vapor-deposited silica film, because the contents of the packaging material 2 can be visually confirmed. The aluminum film may be partly or wholly removable if necessary.

The thickness of the sheet material (single-layer or multi-layer laminate) constituting the packaging material 2 depends on the layer structure and the characteristics (flexibility, strength, water vapor permeability, heat resistance, etc.) of the material used. It is determined appropriately and is not particularly limited, but is usually preferably about 60 to 700 μm,
More preferably, it is about 500 μm.

The sheet material constituting such a packaging material 2 is as follows:
For example, inflation method, T-die method, blow molding method, dry lamination method, hot melt lamination method,
It can be manufactured by various methods such as a coextrusion inflation method, a coextrusion T-die method, and a hot press method.

Next, a second embodiment of the package of the present invention will be described focusing on differences from the first embodiment, and the description of the same items will be omitted.

In the package of the second embodiment, in place of the deodorant 8 in the package 1 shown in FIG. 1, at least a substance having a function of suppressing the growth (propagation) of microorganisms (bacteria, viruses, etc.) is stored. Things. A typical example of this substance is an antibacterial agent, which will be described below. Here, the antimicrobial agent is a general term for substances having a sterilizing, disinfecting, disinfecting, antibacterial or bacteriostatic action.

The antibacterial agent may be either an organic antibacterial agent or an inorganic antibacterial agent. However, from the viewpoint of giving more importance to safety such as prevention of emergence of resistant bacteria, for example, metals, metal oxides, various antibacterial agents, etc. Inorganic antibacterial agents such as ceramics are preferred.

Antibacterial agents can be classified into cell wall synthesis inhibition, cell membrane disorder, protein synthesis inhibition, DNA synthesis disorder, intracellular metabolism disorder, etc. based on their mechanism of action. May be.

[0071] Such antibacterial agents are particularly preferred.
The above-mentioned titanium oxide (TiO 2) _Two).
This titanium oxide is as described above.

The antibacterial agent is housed in a container (packing material) made of, for example, woven fabric, mesh (net-like body) or the like, which has air permeability and liquid permeability, or the container (packaging material) 81 described above. It is preferable that it is housed in the first space 4 in a state where it is closed.

FIG. 2 is a plan view (an internal perspective view) showing a third embodiment of the package of the present invention. Hereinafter, the package of the third embodiment will be described focusing on the differences from the first embodiment, and the description of the same items will be omitted.

As shown in FIG. 2, the package 1 of the third embodiment
Is a sheet-shaped antibacterial agent, that is, an antibacterial sheet 9 stored as an antibacterial agent (at least a substance having a function of suppressing the growth of microorganisms) in the first space 4 of the packaging material 2.

As the antibacterial sheet 9, for example, a sheet,
A material in which an organic antibacterial agent, an antibacterial agent such as a metal having antibacterial activity such as silver, copper or zinc, or an antibacterial agent such as ceramics is supported on a base material such as a porous body. In particular, an inorganic antibacterial agent that is less likely to cause resistant bacteria is preferred.

In the illustrated configuration, the antibacterial sheet 9
Although disposed in a part of the first space 4, an antibacterial sheet sized to cover almost the entire area of the first space 4 can be used. Also, a plurality of antibacterial sheets 9 may be stored.

As in the second and third embodiments, since the antibacterial agent is stored in the first space 4, the used catheter can be used as well as the catheter 7 before or after the packaging material 2 is opened. Even when the catheter 7 is returned to the first space 4, the antibacterial effect can be exerted on the catheter 7, and the transportation and disposal until disposal can be performed sanitarily and safely.

FIG. 3 is a plan view (an internal perspective view) showing a fourth embodiment of the package of the present invention. Hereinafter, the package of the fourth embodiment will be described focusing on the differences from the first embodiment, and the description of the same items will be omitted.

As shown in FIG. 3, the package 1 of the fourth embodiment
Is such that the second space 5 is formed inside the first space 4. That is, the packaging material 2 has a first space 4 in which the catheter 7 and the deodorant 8
(Or an antibacterial agent) and a parcel material (bag) 11 are stored.

The small wrapping material 11 is formed by laminating the same sheet material as the above-mentioned wrapping material 2 and sealing the outer peripheral portion by fusion (or adhesion) to form a bag. , A second space 5 is formed. The fluid substance 10 described above is stored (filled) in the second space 5.

The seal portion on the outer periphery of the parcel material 11 constitutes a partition portion 22 for dividing the second space 5 and the first space 4. A weak seal portion 23 similar to the above is formed in a part of the partition portion 22. By peeling (breaking) the weak seal portion 23, the first space 4 and the second space 5 are separated.
And the fluid substance 10 can flow into the first space 4.

The package 1 having such a structure has the following effects (advantages). First, by selecting the volume of the parcel material 11 to be put into the first space 4, the amount and weight of the contents (such as the fluid substance 10) of the parcel material 11 can be easily set. Secondly, since the parcel material 11 is movable in the first space 4, an operation of peeling (breaking) the weak seal portion 23 and an operation of pushing out the fluid substance 10 and the like from the inside of the parcel material 11 are performed. It can be done easily.
Third, because of the double packaging, the required level of the steam barrier property of the parcel material 11, which is a container of the fluid substance 10, may be lower than that of the first to third embodiments. Thus, the degree of freedom in selecting the constituent material of the package material 11 is increased, and the sheet thickness can be reduced, which is advantageous in manufacturing.
Fourth, since the parcel material 11 can be manufactured independently, manufacturing and management are easy.

In the case of the package 1 of the fourth embodiment, only the small package material 11 may have a steam barrier property.

Next, the method of use (operation) of each package 1 described above will be described.

For example, when the weak seal portion 23 is peeled (ruptured) by the above-described method, the first space 4 and the second space 5 communicate with each other, and the fluidity stored in the second space 5 is removed. The substance 10 flows into the first space 4 and contacts the surface of the catheter 7. Thereby, lubricity is expressed on the surface of the catheter 7, and the frictional resistance is reduced. After peeling (breaking) the weak seal portion 23, if necessary, pressing (pressing) the outside of the packaging material 2 by hand or the like to squeeze out the fluid substance 10 or the like from the second space 5 is performed. May go.

The first space 4 and the second space 5 are sterilized in advance, and the operation of developing the lubricity on the surface of the catheter 7 is performed in the inside of the sealed packaging material 2. Is performed without contact with the outside air, the catheter 7 can maintain sterility.

Since the flowable substance 10 flowing into the first space 4 cannot pass through the container 81, the deodorant 8 in the container 81 does not get wet with the flowable substance 10, so that A decrease in the deodorizing function (deodorizing function) is prevented.

Conventionally, in order to prevent bacterial infection, an operation of immersing a catheter in a disinfecting solution such as a 1% povidone iodoglycerin solution to disinfect the catheter before inserting the catheter into a living body has been performed. However, in many cases, the adjustment of the disinfecting solution is very complicated, and in many cases, it is difficult to obtain the disinfecting solution itself, so that the burden on the patient himself is large and the safety is not sufficiently ensured. Also, for the same catheter,
When used repeatedly for multiple times after repeated disinfection, it may become a breeding ground for bacterial propagation due to the formation of a biofilm on the catheter surface and the like. On the other hand, in the present invention, as described above, the catheter 7 can be brought into a usable state (low friction state) without opening the packaging material 2 and the catheter 7 is kept sterile. Since such a state can be obtained, such a conventional problem is solved.

When the operation of developing the lubricity on the surface of the catheter 7 is completed, the weak seal portion 24 is peeled (ruptured),
The zipper 3 is opened, the catheter 7 in the first space 4 is taken out, and inserted or attached to a target part of the living body. When the catheter 7 is a urethral catheter (urinary catheter), the catheter 7 is inserted into the urethra and the bladder,
Urination is performed via the catheter 7. At this time, the insertion of the catheter 7 can be performed smoothly and safely because the surface of the catheter 7 has lubricity. When urination is completed, the catheter 7 is withdrawn from the urethra.

Although the used catheter 7 is discarded, instead of discarding the catheter 7 alone, the catheter 7 is returned to the first space 4 of the packaging material 2 again, the zipper 3 is closed, and the packaging material is closed. It is preferable to discard every two.

In particular, in the case of self-urination by a patient, it is difficult to use the catheter 7 in the private room of the toilet when going out and then throw it away in the installed trash box.
I would like to take it home and discard it.
In addition, it is not preferable that urine odor emitted from the used catheter 7 leaks to the outside during returning home (during transportation). Furthermore, there is a concern that bacteria, viruses and the like in the urine may propagate due to urine remaining in the catheter 7, which is not hygienic.

In the present invention, when the used catheter 7 is stored in the first space 4 of the packaging material 2, the deodorant 8 eliminates or reduces odors such as urine odor emitted from the catheter 7. Antibacterial agents (titanium oxide, antibacterial sheet 9 etc.)
Inhibits the growth of bacteria, viruses and the like. Thereby, the above-mentioned problems are solved, and the used catheter 7 can be hygienically conveyed without emitting odor.

FIG. 4 is a plan view (internal perspective view) showing a fifth embodiment of the package of the present invention. Hereinafter, the package according to the fifth embodiment will be described focusing on differences from the first embodiment and the like, and description of the same items will be omitted.

As shown in FIG. 4, the package 1 of the fifth embodiment
Has a first space 4, a second space 5, and a third space 6 partitioned by a partition portion 25 in the packaging material 2.

On the outer peripheral portion of the packaging material 2 and the like, a band-shaped sealing portion 21 in which a sheet material constituting the packaging material 2 is fused (or bonded).
Are formed.

The partition 25 is formed by fusing (or adhering) a sheet material in a band shape like the seal portion 21, and has a T-shape. Due to this partition part 25, the inside of the packaging material 2
A first space 4, which is independent (isolated from each other) 4,
It is partitioned into a second space 5 and a third space 6.

In this case, the first space 4, the second space 5, and the third space 6 are arranged adjacent to each other.
Therefore, the second space 5 to the first space 4 as described later
Of liquid to the first space 4 to the third space 6
Can be quickly and reliably performed.

The partition 22 has weak seals 26 and 27 similar to the weak seal 23. By peeling (breaking) the weak seal portion 26, the first space 4 and the second space 5 communicate with each other. By peeling (breaking) the weak seal portion 27, the first space 4 and the third space 3 are broken. Space 6
Communicates with

In the first space 4, the above-mentioned catheter 7 is stored, and in the second space 5, the above-mentioned fluid substance 10 is stored.

The third space 6 contains a water-absorbing material 12 as a substance capable of absorbing and retaining a liquid. Examples of the water absorbing material 12 include a polyacrylate, a polyvinyl alcohol, a polyacrylamide,
Preferred are synthetic polymers such as polyoxyethylene-based or maleic acid-based materials, and polymeric water-absorbing materials such as natural materials such as polysaccharide materials such as starch, cellulose, and alginic acid. In addition, other, for example, sponge,
Examples thereof include cotton, gauze, nonwoven fabric, and those in which the above-mentioned polymer water-absorbing material is supported (for example, those used for diapers, sanitary products, and the like). These water absorbing materials 1
2 can take various forms such as, for example, powder, film, sheet, and fiber (aggregate of fibers).

The first space 4 or the third space 6
In addition, the above-mentioned deodorant and / or antibacterial agent may be stored. In particular, when these are stored in the third space 6, a configuration in which the deodorant (a component having a deodorizing function) and / or an antibacterial agent (a component having an antibacterial function) is carried on the water absorbing material 12 as described above. It is preferable that

FIG. 5 is a plan view (internal perspective view) showing a sixth embodiment of the package of the present invention. Hereinafter, the package of the sixth embodiment will be described focusing on the differences from the fifth embodiment and the like, and the description of the same items will be omitted.

As shown in FIG. 5, the package 1 of the sixth embodiment
The first space 4 and the third space 6 are separated by a partition portion 25 having a weak seal portion 27, and the second space 5 is
Is formed inside the space 4. That is, in the first space 4 of the packaging material 2, the above-described catheter 7 and the same small packaging material (bag body) 11 as described above are stored.

The outer peripheral portion of the package material 11 is constituted by a partition portion 22 having a weak seal portion 23, and a second space 5 is formed inside the partition portion 22. The fluid substance 10 described above is stored (filled) in the second space 5. By peeling (breaking) the weak seal portion 23, the first space 4 and the second space 5 communicate with each other, and the fluid substance 10 can flow into the first space 4.

Further, in the third space 6, the same water-absorbing material (substance capable of absorbing and retaining a liquid) 12 as described above is accommodated.

The package 1 having such a structure has the same effect (advantage) as the package 1 of the fourth embodiment.

FIG. 6 is a plan view (an internal perspective view) showing a seventh embodiment of the package of the present invention. Hereinafter, the package of the seventh embodiment will be described focusing on the differences from the fifth embodiment, the sixth embodiment, and the like, and the description of the same items will be omitted.

As shown in FIG. 6, the package 1 of the seventh embodiment
Is such that the second space 5 and the third space 6 are respectively formed inside the first space 4. That is,
In the first space 4 of the packaging material 2, the catheter 7 described above is provided.
And a parcel material (bag body) 14 are stored.

The small packaging material 14 is formed by stacking the same sheet material as the above-described packaging material 2 and sealing the outer periphery and the middle thereof by fusion (or adhesion) to form a bag. Inside, a second space 5 and a third space 6 are formed via a partition 28.

In the second space 5, the above-mentioned fluid substance 1
0 is stored (filled), and the above-described water-absorbing material (substance capable of absorbing and holding a liquid) 12 is stored in the third space 6.

The outer peripheral portion of the package material 14 and the seal portion crossing the middle thereof constitute a partition portion 28 for isolating (partitioning) the first space 4, the second space 5 and the third space 6. A weak seal portion 26 for opening the second space 5 and a weak seal portion 27 for opening the third space 6 are formed in a part of the partition portion 28. In this embodiment,
The weak seal portions 27 are provided at two places.

The package 1 having such a structure has the following effects (advantages). First, by selecting the capacity of the parcel material 14 to be put in the first space 4 (the respective capacities of the second space 5 and the third space 6), the contents (fluidity) of the parcel material 14 are selected. Substance 10 and water absorbing material 12)
Amount and weight can be easily set. Secondly, since the parcel material 14 is movable in the first space 4, an operation of peeling (breaking) the weak seal portions 26 and 27 or squeezing out the fluid substance 10 or the like from the second space 5. The operation and the operation of collecting the liquid into the third space 6 can be easily performed (at an appropriate position). The same applies to the third and fourth advantages of the above-described parcel material 11.

In this embodiment, the second space 5 and the third space 6 are formed in one parcel material 14.
The present invention is not limited to this. Two separated parcels are stored in the first space 4, and the second parcels 5
And the third space 6 may be formed.
With this configuration, the same effect as described above can be obtained.

FIG. 7 is a plan view (internal perspective view) showing an eighth embodiment of the package of the present invention. Hereinafter, the package of the eighth embodiment will be described focusing on differences from the fifth embodiment and the like, and the description of the same items will be omitted.

As shown in FIG. 7, the package 1 of the eighth embodiment
Has a U-shaped second space 5 on the lower end side, and the above-mentioned fluid substance 10 is stored (filled) in the second space 5.

A third space 6 is formed inside the second space 5 (on the center side of the packaging material 2) via a U-shaped partition portion 29, and is formed in the third space 6. Contains the water-absorbing material (substance capable of absorbing and retaining a liquid) 12 described above.

The partition 25 separates the first space 4 from the second space 5 and the first space 4 from the third space 6, respectively. The partition 25 has a weak seal 27 for opening the third space 6.

On one side of the partition 25, a sealing member 13 which can be broken and opened is provided. The sealing member 13 is fused to the partition 25 so as to intersect with the partition 25. Hereinafter, the configuration of the sealing member 13 will be described.

FIG. 8 is a longitudinal sectional view showing an example of the structure of the sealing member 13. As shown in FIG. As shown in the figure, a sealing member 13 is composed of a short tube 131 made of a flexible resin such as soft polyvinyl chloride,
1 and a cylindrical body 132 whose one end is closed by a solid columnar portion 133.

The upper end of the short tube 131 in FIG.
8 and the lower end of the cylindrical body 132 in FIG.
Space 5.

A thin and fragile breaking portion 134 is formed on the outer periphery in the middle of the cylindrical body 132. The internal flow path of the sealing member 13 is opened by bending the solid columnar portion 133 together with the short tube 131 from the outside of the short tube 131 by the finger or the like to break the broken portion 134 and separate the solid columnar portion 133. . Thereby, the first space 4 and the second space 5
And the fluid substance 10 in the second space 5 can flow into the first space 4.

As a constituent material of the cylindrical body 132, for example,
Hard materials such as hard polyvinyl chloride, polycarbonate, and polyester are exemplified.

The upper end 135 of the solid columnar portion 133 is also provided.
Has a wedge shape (flat shape). Thereby, after the solid columnar part 133 is fractured and separated, the solid columnar part 133 is separated.
However, the short tube 131 is not closed, and a sufficient liquid flow can be secured.

The inner diameter of the upper end of the short tube 131 in FIG. 8 is reduced, so that the solid columnar portion 133 after breaking and separation cannot pass through the reduced diameter portion 136. I have. Thus, the solid columnar portion 133 that has been broken and separated can be prevented from entering the first space 4 and freely moving in the first space 4.

In the fifth, sixth, seventh, and eighth embodiments, the second space 5 contains the fluid substance 10, but in each of these embodiments, Instead of the fluid substance 10, a liquid containing a blood anticoagulant (antithrombotic) may be stored in the second space 5. Thereby, when using the catheter 7, a blood anticoagulant function can be provided to the catheter 7.
Examples of the blood anticoagulant include those shown in Table 1 below.

[0126]

[Table 1]

In each of the above embodiments, the packaging material 2 is made of a flexible sheet material. However, the present invention is not limited to this. For example, a part of the packaging material 2 is made of a relatively hard material. May be used. A specific example thereof is a so-called blister container. The blister container is made of a relatively hard material, and includes a main body having a recess forming a storage space (for example, a first space), and a film for hermetically sealing an opening of the recess.
The film is opened by peeling off the film.

Next, the method of use (operation) of each package 1 of the fifth to eighth embodiments will be described. When the weak seal portion 23 or 26 is peeled (ruptured) (in the case of the eighth embodiment,
When the solid columnar portion 133 of the sealing member 13 is broken and separated),
The first space 4 and the second space 5 communicate with each other, and the second space 5
The fluid substance 10 stored therein flows into the first space 4 and comes into contact with the surface of the catheter 7. This allows
Lubricity is developed on the surface of the catheter 7, and frictional resistance is reduced. If necessary, the fluid substance 10 is pressed from the outside of the packaging material 2 by hand (pressing) from the second space 5.
For example, an operation of ironing out may be performed.

The first space 4 and the second space 5 have been sterilized in advance, and the operation of developing the lubricity on the surface of the catheter 7 is performed in the inside of the sealed packaging material 2. Is performed without contact with the outside air, the catheter 7 can maintain sterility. As described above, the catheter 7 can be used without opening the packaging material 2 (low friction state), and such a state can be achieved while maintaining the sterility of the catheter 7. Therefore, the conventional problem described above is solved.

When the operation for developing the lubricity on the surface of the catheter 7 is completed, the weak seal portion 24 is peeled off (ruptured).
The zipper 3 is opened, the catheter 7 in the first space 4 is taken out, and inserted or attached to a target part of the living body. When the catheter 7 is a urethral catheter (urinary catheter), the catheter 7 is inserted into the urethra and the bladder,
Urination is performed via the catheter 7. At this time, the insertion of the catheter 7 can be performed smoothly and safely because the surface of the catheter 7 has lubricity. When urination is completed, the catheter 7 is withdrawn from the urethra.

Although the used catheter 7 is discarded, instead of discarding the catheter 7 alone, the catheter 7 is returned to the first space 4 of the packaging material 2 again, the zipper 3 is closed, and the packaging material is closed. It is preferable to discard every two.

At this time, the weak seal portion 27 is peeled (ruptured) and opened by the method described above. As a result, the first space 4 and the third space 6 communicate with each other, and bodily fluids such as urine adhered to the surface of the catheter 7 or remaining in the catheter 7 are stored in the third space 6. Can be absorbed and retained by the water-absorbing material 12. As a result, leakage of bodily fluids such as urine can be more reliably prevented, and the used catheter 7 can be conveyed hygienically with the packaging material 2 and discarded.

In particular, when the water-absorbing material 12 carries a deodorant (a component having a deodorizing function) and / or an antibacterial agent (a component having an antibacterial function), it emits odor and prevents bacteria, viruses and the like. Proliferation can be suppressed, and more hygienic and safe transport and disposal can be performed.

As described above, according to the package 1 of the present invention, it is possible to easily and aseptically contact the lubricant, blood anticoagulant, etc. with the catheter, and also to carry and unpack the patient. Not only is it simple, but it can also be transported and disposed of hygienically and safely after use of the catheter.

[0135] In the present invention, examples of instruments housed in the first space 4 include the following.

Oral or nasal such as gastric tube catheter, feeding catheter, tube for tube feeding, oxygen catheter, oxygen cannula, tube and cuff for endotracheal tube, tube and cuff for tracheostomy tube, intratracheal suction catheter, etc. Catheters to be inserted and detained.

Catheters to be inserted and placed in various body cavities, organs, and tissues such as suction catheters, drainage catheters, peritoneal catheters, rectal catheters, and trocars.

Catheters to be inserted and placed in blood vessels such as angiographic catheters, PTCA balloon catheters, IABP balloon catheters, indwelling catheters, and arterial infusion catheters.

Various guidewires used alone or with each of the catheters described above.・ Artificial blood vessels, stents, colostomy, artificial bones, artificial joints, prostheses, artificial eyes.・ Injection needle, indwelling needle, sheath, catheter introducer.

An endoscope, a cardiac output measuring instrument, an ultrasonic measuring / diagnosing instrument, an ultrasonic crushing probe, a pacemaker,
Thermometer.・ Thread for suture or ligature ・ Enema ・ Contact lens ・ Contraceptive device such as condom

In the present invention, the arrangement of the first space 4, the second space 5, and the third space 6 is not limited to that of each of the illustrated embodiments. And the third space may be arranged in a line in this order. Further, the packaging material may further have a fourth space.

The first space 4, the second space 5, and the third space 6 may each contain any other than the above.

[0143]

The present invention will be specifically described below with reference to examples.

Example 1A Polypropylene (XF18)
00, manufactured by Chisso Corporation and 60 parts by weight and a styrene-based elastomer (Hybra HVS-3, manufactured by Kuraray Co., Ltd.), 40 parts by weight, are used to form an inflation sheet (thickness: 300 μm, water vapor permeability: 15 g) by co-extrusion molding. / m ² · 24
hrs, 25 μm thickness, 40 ° C., 90% RH). This sheet was sealed by heat sealing to form a packaging material having the configuration shown in FIG.

In the first space of the packaging material, a Neraton catheter (Safide, 14Fr, manufactured by Terumo Corporation) as a catheter used by being inserted into the urethra, and a water-impermeable porous material made of polyethylene Non-woven fabric (trade name: TYPEC, Asahi DuPont Flash Span Products Co., Ltd.)
Deodorant / air freshener (trade name: Airnip, manufactured by Tact Co., Ltd.). In addition, as for this Neraton catheter, the surface has a 0.2 wt% polyvinylpyrrolidone-chloroform solution (trade name: Kolydone K).
30, BASF Japan Co., Ltd.) coated with a layer of a hydrophilic polymer material. Also, in the second space of the packaging material, put 10 ml of water,
Sealed.

Sealing part of packaging material (part other than weak sealing part)
Was heat-sealed at 200 ° C. for 4 seconds and 0.25 kgf / cm ² , and the weakly sealed portion was heat-sealed at 105 ° C. for 4 seconds and 0.25 kgf / cm ² and subjected to high-pressure steam sterilization at 110 ° C. for 60 minutes. .

After sterilization, the package was vibrated violently, but peeling of the weak seal was not observed, and there was no contact between water and the catheter.

Next, when the packaging material was pressed and pressed by hand to apply a load to the weak seal portion 23, only the weak seal portion 23 was peeled off, and water in the second space was introduced into the first space. It spilled and came into contact with the catheter. Thereby, it was confirmed that the water and the catheter can be easily and aseptically contacted with each other.

After contact of the catheter with water, the weak seal portion 24 was opened, and the catheter was taken out and rubbed against the surface. As a result, the surface showed lubricity, the frictional resistance was reduced, and It was suggested that the operability of the insertion operation was improved.

Thereafter, the catheter was immersed in artificial urine having the components shown in Table 2 below for 30 seconds. Then, the catheter was returned to the first space of the packaging material, and the zipper was closed and sealed, and left for a predetermined time. The face was brought close to the packaging material, but no unpleasant sensation such as urine odor was observed.

Therefore, after using the catheter, the patient can easily take the catheter home without hesitation around, and can not only be relieved from the mental burden but also have a urinary odor to the outside air. Does not leak,
It was suggested that it was also favorable for hygiene.

[0152]

[Table 2]

(Examples 2A, 3A and 4A) The same inflation sheet as in Example 1A was sealed by heat sealing to form a packaging material having the structure shown in FIG.

In the first space of the packaging material, the same Neraton catheter (without surface coating) as described above was placed, and in the second space, a lubricant having the composition shown in Table 3 below was placed, and each was hermetically sealed. did. In the first space, a deodorant, an fragrance, and the like packaged with a water-impermeable porous body shown in Table 3 below were placed.

[0155]

[Table 3]

Sealing part of packaging material (part other than weak sealing part)
Was heat-sealed at 200 ° C. for 4 seconds and 0.25 kgf / cm ² , and the weakly sealed portion was heat-sealed at 105 ° C. for 4 seconds and 0.25 kgf / cm ² and subjected to high-pressure steam sterilization at 110 ° C. for 60 minutes. .

After sterilization, the package was vibrated violently, but peeling of the weak seal was not observed, and there was no contact between the liquid in the second space and the catheter.

Next, when the packaging material was pressed and pressed by hand and a load was applied to the weak seal portion 23, only the weak seal portion 23 was peeled off, and the liquid in the second space was introduced into the first space. It spilled and came into contact with the catheter. Thereby, it was confirmed that the liquid and the catheter can be easily and aseptically contacted with each other.

After the contact between the liquid in the second space and the catheter, the weak seal portion 24 was opened, and the catheter was taken out and rubbed against the surface. The sliding resistance value on the surface has been reduced,
The improvement of the operability of the insertion operation into the body cavity was suggested.

Thereafter, the catheter was immersed in artificial urine having the components shown in Table 2 for 30 seconds. Then, the catheter was returned to the first space of the packaging material, and the zipper was closed and sealed, and left for a predetermined time. I brought my face close to the packaging material, but I felt a urine odor.
No unpleasant feeling was observed.

Therefore, after using the catheter, the patient can easily take the catheter home without hesitation around, and can not only be relieved from the mental burden, but also have a urinary odor to the outside air. Does not leak,
It was suggested that it was also favorable for hygiene.

(Examples 5A and 6A) The same inflation sheet as in Example 1A was sealed by heat sealing to form a packaging material having the structure shown in FIG.

In the first space of the packaging material, the same Neraton catheter (without surface coating) as described above was placed, and in the second space, a lubricant having the composition shown in Table 4 below was placed, and each was hermetically sealed. did. In the first space, an antimicrobial sheet shown in Table 4 below was placed.

[0164]

[Table 4]

Sealing part of packaging material (part other than weak sealing part)
Was heat-sealed at 200 ° C. for 4 seconds and 0.25 kgf / cm ² , and the weakly sealed portion was heat-sealed at 105 ° C. for 4 seconds and 0.25 kgf / cm ² and subjected to high-pressure steam sterilization at 110 ° C. for 60 minutes. .

After sterilization, the package was vibrated violently, but peeling of the weak seal was not observed, and there was no contact between the liquid in the second space and the catheter.

Next, when the packaging material was pressed and pressed by hand to apply a load to the weak seal portion 23, only the weak seal portion 23 was peeled off, and the liquid in the second space was introduced into the first space. It spilled and came into contact with the catheter. Thereby, it was confirmed that the liquid and the catheter can be easily and aseptically contacted with each other.

After the liquid in the second space and the catheter came into contact with each other, the weak seal portion 24 was opened, the catheter was taken out, and the surface was rubbed. The sliding resistance value on the surface has been reduced,
The improvement of the operability of the insertion operation into the body cavity was suggested.

Thereafter, the catheter was immersed in artificial urine having the components shown in Table 2 for 30 seconds. Then, the catheter was returned to the first space of the packaging material, and the zipper was closed and sealed, and left for a predetermined time. I brought my face close to the packaging material, but I felt a urine odor.
No unpleasant feeling was observed. Furthermore, the antibacterial action of the antibacterial sheet suppressed the proliferation of urinary bacteria, viruses and the like adhering to and remaining on the catheter.

[0170] Therefore, after using the catheter, the patient can easily take the catheter home without hesitating to the surroundings, and not only can be released from the mental burden, but also can have urinary odor to the outside air. It was suggested that it was preferable from the viewpoint of hygiene, because there was no possibility of leakage and no possibility of bacterial infection.

(Example 7A) The same inflation sheet as in Example 1A was sealed by heat sealing to form a packaging material having the structure shown in FIG.

In the first space of the packaging material, the same Neraton catheter (having the same surface as in Example 1A) was placed, and in the second space, 10 ml of water was placed.
And sealed each. In the first space,
Deodorizing and antibacterial sheet containing titanium oxide (trade name: PM-I
N-CD, manufactured by Mitsubishi Paper Mills).

Sealing part of packaging material (part other than weak sealing part)
Was heat-sealed at 200 ° C. for 4 seconds and 0.25 kgf / cm ² , and the weakly sealed portion was heat-sealed at 105 ° C. for 4 seconds and 0.25 kgf / cm ² and subjected to high-pressure steam sterilization at 110 ° C. for 60 minutes. .

After sterilization, the package was vibrated violently, but peeling of the weak seal was not observed, and there was no contact between the liquid in the second space and the catheter.

Next, when the packaging material was pressed and pressed by hand and a load was applied to the weak seal portion 23, only the weak seal portion 23 was peeled off, and water in the second space was introduced into the first space. It spilled and came into contact with the catheter. Thereby, it was confirmed that the water and the catheter can be easily and aseptically contacted with each other.

After the water in the second space came into contact with the catheter, the weak seal portion 24 was opened, and the catheter was taken out and rubbed against the surface. The sliding resistance on the surface was significantly reduced, suggesting improved operability of the insertion operation into the body cavity.

Thereafter, the catheter was immersed in artificial urine having the components shown in Table 2 for 30 seconds. Then, the catheter was returned to the first space of the packaging material, the zipper was closed and sealed, and left for a predetermined time. I brought my face close to the packaging material, but I felt a urine odor.
No unpleasant feeling was observed. Furthermore, the antibacterial action of the deodorizing / antibacterial sheet suppressed the proliferation of bacteria, viruses, and the like in the urine that had adhered to and remained on the catheter.

Therefore, after using the catheter, the patient can easily take the catheter home without hesitating to the surroundings, and can not only be relieved from the mental burden, but also can have urinary odor to the outside air. It was suggested that it was preferable from the viewpoint of hygiene, because there was no possibility of leakage and no possibility of bacterial infection.

(Example 8A) The same inflation sheet as in Example 1A was sealed by heat sealing to form a packaging material containing a small packaging material having the structure shown in FIG.

In the first space of the packaging material, the same Neraton catheter and the small packaging material as in Example 1A were put and sealed.
The second space of the parcel material was filled with 20 ml of water and sealed. In the first space, a deodorant / fragrance (trade name) packaged by a polyethylene nonwoven fabric (trade name: TYPEC, manufactured by Asahi DuPont Flash Spun Products Co., Ltd.) which is a water-impermeable porous body : Air Nip, manufactured by Tact Co., Ltd.).

The sealing part (the part other than the weak sealing part) of the packaging material and the small packaging material is 200 ° C., 4 seconds, 0.25 kgf / c
m ^2, and the weak seal portion, 105 ° C., 4 seconds, 0.25 kg
f / cm ² at 110 ° C, 60
The autoclave was autoclaved for a minute.

After sterilization, the package was vibrated violently, but peeling of the weak seal was not observed, and there was no contact between the liquid in the second space and the catheter.

Next, when the small packaging material was pressed and pressed by hand from above the packaging material to apply a load to the weak seal portion 23, only the weak seal portion 23 was peeled off, and the water in the second space was removed from the second space. 1 and came into contact with the catheter. Thereby, it was confirmed that the water and the catheter can be easily and aseptically contacted with each other. In addition, since this operation was performed by moving the small package material to a suitable position in the package material, the opening operation of the small package material could be performed more easily and reliably.

After the water in the second space came into contact with the catheter, the weak seal portion 24 was opened, and the catheter was taken out and rubbed against the surface. The sliding resistance on the surface was significantly reduced, suggesting improved operability of the insertion operation into the body cavity.

Thereafter, the catheter was immersed in artificial urine having the components shown in Table 2 for 30 seconds. Then, the catheter was returned to the first space of the packaging material, the zipper was closed and sealed, and the container was left for a predetermined time. I brought my face close to the packaging material, but I felt a urine odor.
No unpleasant feeling was observed. Further, the antibacterial action of the deodorizing / antibacterial agent suppressed the proliferation of bacteria and viruses in urine attached to and remaining on the catheter.

Therefore, after using the catheter, the patient can easily take the catheter home without hesitating to the surroundings, and can not only be relieved from the mental burden, but also have a urinary odor to the outside air. It was suggested that it was preferable from the viewpoint of hygiene, because there was no possibility of leakage and no possibility of bacterial infection.

Example 1B Polypropylene (XF18)
00, manufactured by Chisso Corporation and 60 parts by weight and a styrene-based elastomer (Hybra HVS-3, manufactured by Kuraray Co., Ltd.), 40 parts by weight, are used to form an inflation sheet (thickness: 300 μm, water vapor permeability: 15 g) by co-extrusion molding. / m ² · 24
hrs, 25 μm thickness, 40 ° C., 90% RH). This sheet was sealed by heat sealing to form a packaging material having the structure shown in FIG.

In the first space of the packaging material, the same Neraton catheter as in Example 1A was placed, in the second space, 10 ml of water was placed, and in the third space, a cross-linking material, which was a water-absorbing material, was placed. Sodium polyacrylate (trade name: Aquaric,
1 g of Nippon Shokubai Kagaku Kogyo Co., Ltd.) was added, and each was sealed.

Sealing part of packaging material (parts other than weak seal part)
Was heat-sealed at 200 ° C. for 4 seconds at 0.25 kgf / cm ² , and the weakly sealed portion was heat-sealed at 105 ° C. for 4 seconds at 0.25 kgf / cm ² , and γ-ray sterilized at ² Mrad.

After sterilization, the package was vibrated violently, but peeling of the weak seal was not observed, and there was no contact between water and the catheter and no contact between water and the water-absorbing material.

Next, when the packaging material was pressed and pressed by hand and a load was applied to the weak seal portion 26, only the weak seal portion 26 was peeled off, and the water in the second space was introduced into the first space. It spilled and came into contact with the catheter. Thereby, it was confirmed that the water and the catheter can be easily and aseptically contacted with each other.

After contact of the catheter with water, the weak seal portion 24 was opened, and the catheter was taken out and rubbed against the surface. As a result, the surface showed lubricity, reduced frictional resistance, and reduced the body cavity. It was suggested that the operability of the insertion operation was improved.

Thereafter, the catheter was soaked in bovine blood for 30 seconds, and then the catheter was returned to the first space of the packaging material, and the zipper was closed and sealed.

Next, when the weak seal portion 27 was opened to make the first space and the third space communicate with each other and the packaging material was vibrated, the blood adhering and remaining on the surface and inside of the catheter was removed. The water was absorbed and retained by the water-absorbing material in the third space. Therefore, even if the zipper was opened, blood did not leak.

Therefore, even if the used catheter is transported in a packaging material and discarded together with the packaging material, there is no blood leakage during that time, blood contamination and infection are prevented, and high safety is suggested. Was done.

(Example 2B) The same inflation sheet as in Example 1B was sealed by heat sealing to form a packaging material containing a small packaging material having the structure shown in FIG.

In the first space of the packaging material, the same Neraton catheter and guide wire (inserted into the lumen of the catheter) as in Example 1A and a small packaging material are placed.
Sealed. In the second space of the package material, 18 ml of the CPDA-1 solution shown in Table 1 above was placed as a blood anticoagulant solution and sealed. In a third space of the packaging material, 2 g of crosslinked sodium polyacrylate (trade name: Aquaric, manufactured by Nippon Shokubai Chemical Industry Co., Ltd.) as a water-absorbing material was placed and sealed.

The sealing part (the part other than the weak sealing part) of the packaging material and the small packaging material is 200 ° C., 4 seconds, 0.25 kgf / c
m ^2, and the weak seal portion, 105 ° C., 4 seconds, 0.25 kg
heat seal at f / cm ² and γ at ² Mrad
X-ray sterilization was performed.

After sterilization, the package was vibrated violently, but peeling of the weak seal was not observed, and there was no contact between the anticoagulant solution and the catheter and between the anticoagulant solution and the water absorbent material. .

Next, when the small package material was pressed and pressed by hand from above the package material to apply a load to the weak seal portion 23, only the weak seal portion 23 was peeled off, and the anticoagulant in the second space was removed. The liquid is first
Out of the space and contacted the catheter. Thereby, it was confirmed that the anticoagulant solution and the catheter can be easily and aseptically contacted with each other. In addition, since this operation was performed by moving the small package material to a suitable position in the package material, the opening operation of the small package material could be performed more easily and reliably.

After contact between the anticoagulant solution and the catheter, the weak seal portion 24 was opened, the catheter was taken out, and the surface was rubbed. The catheter surface showed lubricity due to the moisture of the anticoagulant solution. , The frictional resistance has been reduced,
The improvement of the operability of the insertion operation into the body cavity was suggested. Also,
Since the anticoagulant is attached to the surface of the catheter,
It is considered that when inserted into a blood vessel, an excellent anticoagulant effect is exhibited.

Thereafter, the catheter was soaked in bovine blood for 30 seconds, and then the catheter was returned to the first space of the packaging material, and the zipper was closed and sealed.

Next, when the weak seal portion 27 is opened to make the first space and the third space communicate with each other and the packaging material is vibrated, the blood adhering and remaining on the surface and inside of the catheter is removed. The water was absorbed and retained by the water-absorbing material in the third space. Therefore, even if the zipper was opened, blood did not leak.

Therefore, even if the used catheter is transported in a packaging material and discarded together with the packaging material, there is no leakage of blood during that time, blood contamination and infection are prevented, and safety is high. Was done.

Example 3B An inflation sheet similar to that of Example 1B was sealed by heat sealing to form a packaging material containing a small packaging material having the structure shown in FIG.

In the first space of the packaging material, the same Neraton catheter and guide wire (in the state inserted into the lumen of the catheter) and the small packaging material as in Example 1A were placed.
Sealed. In the second space of the parcel material, 18 ml of the heparin solution shown in the above Table 1 was put as a blood anticoagulant solution, and in the third space, crosslinked sodium polyacrylate (trade name: Aquaric), which is a water-absorbing material. , Nippon Shokubai Chemical Industry Co., Ltd.
2 g) were sealed and each was sealed.

The sealing part (the part other than the weak sealing part) of the packaging material and the small packaging material is 200 ° C., 4 seconds, 0.25 kgf / c.
m ^2, and the weak seal portion, 105 ° C., 4 seconds, 0.25 kg
heat seal at f / cm ² and γ at ² Mrad
X-ray sterilization was performed.

After sterilization, the package was vibrated violently, but peeling of the weak seal was not observed, and there was no contact between the anticoagulant solution and the catheter and no contact between the anticoagulant solution and the water absorbent material. .

Next, when the upper half of the small packaging material in FIG. 6 was pressed and pressed by hand from above the packaging material to apply a load to the weak seal portion 26, only the weak seal portion 26 was peeled off, and the second The anticoagulant liquid in the space flowed out into the first space and came into contact with the catheter. Thereby, it was confirmed that the anticoagulant solution and the catheter can be easily and aseptically contacted with each other. In addition,
Since this operation was performed by moving the small packaging material to a suitable position within the packaging material, the operation of opening the weak seal portion 26 could be performed more easily and reliably.

After the anticoagulant solution was brought into contact with the catheter, the weak seal portion 24 was opened, the catheter was taken out, and the surface was rubbed. The catheter surface showed lubricity due to the moisture of the anticoagulant solution. , The frictional resistance has been reduced,
The improvement of the operability of the insertion operation into the body cavity was suggested. Also,
Since the anticoagulant is attached to the surface of the catheter,
It is considered that when inserted into a blood vessel, an excellent anticoagulant effect is exhibited.

Thereafter, the catheter was dipped in bovine blood for 30 seconds, and then the catheter and the guide wire were returned to the first space of the packaging material, and the zipper was closed and sealed.

Next, the weak seal portion 27 of the parcel material is opened to make the first space and the third space communicate with each other, and when the wrapping material is vibrated, it adheres and remains on the surface and inside of the catheter. The collected blood was absorbed and retained by the water-absorbing material in the third space. Therefore, even if the zipper was opened, blood did not leak. In addition, since this operation was performed by moving the small packaging material to a suitable position in the packaging material, the opening operation of the weak seal portion 27 and the absorption of the remaining blood could be performed more easily and reliably.

Therefore, even if the used catheter is transported in a packaging material and discarded together with the packaging material, there is no blood leakage during that time, thereby preventing contamination and infection, and suggesting high safety. Was done.

(Examples 4B, 5B, 6B) The same inflation sheet as in Example 1B was sealed by heat sealing to form a packaging material having the structure shown in FIG.

In the first space of the packaging material, the same Neraton catheter as in Example 1B (without surface coating)
, And a lubricant having the composition shown in Table 5 below was placed in the second space, and each was sealed. The third space was filled with a water-absorbing material shown in Table 5 below and sealed.

[0216]

[Table 5]

Sealing part of packaging material (part other than weak sealing part)
Was heat-sealed at 200 ° C. for 4 seconds at 0.25 kgf / cm ² , and the weakly sealed portion was heat-sealed at 105 ° C. for 4 seconds at 0.25 kgf / cm ² , and γ-ray sterilized at ² Mrad.

After sterilization, the package was vibrated violently, but no peeling of the weak seal portion or breakage of the sealing member was observed.
There was no contact between the lubricant and the catheter and no contact between the lubricant and the water-absorbing material.

Next, the sealing member (the structure shown in FIG. 8) is bent by hand from the outside of the packaging material, the solid columnar portion is broken and separated at the breaking portion, and the portion of the second space of the packaging material is pressed. As a result, the lubricant in the second space flowed into the first space and came into contact with the catheter. Thereby, it was confirmed that the lubricant can be easily and aseptically contacted with the catheter.

[0220] After contact between the lubricant and the catheter, the weak seal portion 24 was opened, and the catheter was taken out and rubbed against the surface. As a result, the surface showed lubricity and the frictional resistance was reduced. It was suggested that the operability of the insertion operation into the device was improved.

Thereafter, the catheter was immersed in artificial urine having the components shown in Table 2 for 30 seconds, and then the catheter was returned to the first space of the packaging material, and the zipper was closed and sealed.

Next, the weak seal portion 27 was opened to make the first space and the third space communicate with each other, and when the packaging material was vibrated, the artificial urine adhering and remaining on the surface and inside of the catheter was removed. Was absorbed and retained by the water-absorbing material in the third space. Therefore, even if the zipper was opened, leakage of artificial urine did not occur.

Therefore, even if the used catheter is transported in a packaging material and discarded together with the packaging material, there is no leakage of bodily fluids such as urine during that time, thereby preventing contamination and infection and high safety. It has been suggested.

(Example 1C) As a sheet constituting a packaging material, polypropylene (manufactured by Mitsubishi Chemical Corporation, SPX960)
0) monolayer film (film thickness 300 μm, water vapor transmission rate 21 g / m ² · 24 hrs · 25 μm thickness · 40 ° C. ·
A package having the configuration shown in FIG. 1 was manufactured in the same manner as in Example 1A except that 90% RH) was used. The items stored in the first space and the second space of the packaging material are the same as those in the embodiment 1A.

(Example 2C) A linear low-density polyethylene (Nippon Polychem Co., Ltd.)
Monolayer film (film thickness 30) made of a polymer blend of Novatec LL UF340 manufactured by Novotech Co., Ltd. and polypropylene (Chisso Polypro K7714 manufactured by Chisso Corp.)
0 μm, water vapor transmission rate 18 g / m ²・ 24 hrs ・ 25 μ
Example 1 except that m-thickness / 40 ° C./90% RH) was used.
A package having the configuration shown in FIG. 1 was manufactured in the same manner as in A.
The items stored in the first space and the second space of the packaging material are the same as those in the embodiment 1A.

(Example 3C) As a sheet constituting a packaging material, a two-layer composed of a first layer made of a polymer blend film of linear low-density polyethylene and polypropylene and a second layer made of a silica-deposited polyethylene terephthalate film Laminated film (Dai Nippon Printing Co., Ltd.
Film thickness 300 [mu] m, water vapor permeability 0.6g / m ² · ²
4 hrs, 25 μm thickness, 40 ° C., 90% RH)
A package having the configuration shown in FIG. 1 was manufactured in the same manner as in Example 1A, except that the layers were used so as to be joined to each other. The storage items in the first space and the second space of the packaging material are also the same as those of the first embodiment.
Same as A.

(Example 4C) As sheets constituting the packaging material, the first layer of a polymer blend film of linear low-density polyethylene and polypropylene, the second layer of an aluminum film, and the third layer of a polyethylene terephthalate film Constructed three-layer laminated film (Toyo Aluminum Co., Ltd., film thickness 300μ)
m, water vapor transmission rate 0.3 g / m ² · 24 hrs · 25 µ
m thickness, 40 ° C., 90% RH) in the same manner as in Example 1A, except that the first layers were joined to each other.
Was manufactured. The items stored in the first space and the second space of the packaging material are also the same as those in Example 1A.

Example 5C Example 4C was repeated except that the liquid stored in the second space was 10 ml of an aqueous glycerin solution (manufactured by Kenei Pharmaceutical Co., Ltd., glycerin concentration: 84 to 87%).
A package similar to the above was produced.

<Test 1> Each package of Examples 1C to 5C was left for 4 weeks in an environment of a temperature of 40 ° C. and a humidity of 75% RH.
After one week, two weeks and four weeks, the second
The change over time in the rate of decrease of the liquid stored in the space was examined. The results are shown in Table 6 below. Here, the reduction rate of the liquid was calculated by the following equation.

Reduction rate (%) = (W ₀ −W) / W ₀ × 100 where W ₀ : the total weight of the liquid at the start of the test (10 g) W: each liquid after 2, 4 and 4 weeks Weight of

[0231]

[Table 6]

As shown in Table 6, in all of the packages of Examples 1C to 5C, since the packaging material had a steam barrier property, the reduction rate of the liquid was low. It was confirmed that the reduction and concentration could be prevented, and the invasion of water vapor into the first space could be prevented.

In particular, the water vapor permeability is 1 g / m ² · 24 h
Example 3 rs, 25 μm thickness, 40 ° C., 90% RH or less
The package of C to 5C has a very small reduction rate of the liquid, and such an effect is more remarkably exhibited. Example 5C
In, the liquid stored in the second space was an aqueous glycerin solution having a lower volatility than water, so that the liquid hardly decreased.

<Test 2> Each of the packages of Examples 1C to 5C was left in the above environment for another 4 weeks. However, peeling of the weak seal portions 23 and 24 was not observed, and water from the second space was not observed. No leakage occurred.

After that, when the portion forming the second space of the packaging material was pressed and pressed by hand, the weak seal portion 23 could be easily and reliably peeled off from any of the packages, and It was confirmed that peel sealability was ensured.

<Study of Effective Storage Period of Package> In the package according to the present embodiment, when the liquid stored in the second space is reduced by evaporation and its weight becomes about half or less,
It becomes difficult to open (peel) the weak seal portion by applying pressure. Therefore, the time required for the amount of liquid stored in the second space to decrease by half under the test conditions was calculated by the following equation.

Time (year) = (5 g / ΔW) × (28 days / 365 days) Here, ΔW: reduction amount of liquid after 4 weeks ΔW = 10 g × (rate of reduction of liquid after 4 weeks / 100)

As a result, 1.9 years was obtained in Example 1C, 2.2 years in Example 2C, 5.4 years in Example 3C, and 1 year in Example 4.
It is 2.7 years and 38.0 years in Example 5C.

From the above results, by using a packaging material having a steam barrier property as in Examples 1C to 5C,
It has been found that it is possible to suppress a decrease in the stored liquid and to hold the liquid for a long time.

[0240]

As described above, according to the present invention, a device such as a catheter can be easily and aseptically contacted with a liquid. In particular, the communication operation between the isolated spaces in the packaging material and the opening operation of the packaging material can be performed easily and reliably.

The type of liquid stored in the second space,
By selecting the composition, amount, etc., various functions are imparted to the device, in particular, advantageous functions such as surface lubrication and anticoagulation (antithrombotic) when inserting or attaching the device to a living body. Can be.

In addition, by storing used equipment in a packaging material, it is possible to prevent the emission of odors to the outside, the growth of microorganisms, or the prevention of contamination and infection due to leakage of liquid adhering or remaining on the equipment. And contribute to the improvement of safety. It is also advantageous for downsizing the package. Therefore, it is advantageous for the disposal of used equipment or for transportation and storage until disposal.

In particular, in the case of self-urination in which the patient himself urinates using a catheter, labor and mental burden are reduced in transporting and disposing of the used catheter when going out, so that the patient's comfortable life (quality・ Of life).

[Brief description of the drawings]

FIG. 1 is a plan view (an internal perspective view) showing a first embodiment of a package of the present invention.

FIG. 2 is a plan view (an internal perspective view) showing a third embodiment of the package of the present invention.

FIG. 3 is a plan view (an internal perspective view) showing a fourth embodiment of the package of the present invention.

FIG. 4 is a plan view (an internal perspective view) showing a fifth embodiment of the package of the present invention.

FIG. 5 is a plan view (an internal perspective view) showing a sixth embodiment of the package of the present invention.

FIG. 6 is a plan view (an internal perspective view) showing a seventh embodiment of the package of the present invention.

FIG. 7 is a plan view (an internal perspective view) showing an eighth embodiment of the package of the present invention.

FIG. 8 is a longitudinal sectional view illustrating a configuration example of a sealing member.

[Explanation of symbols]

 DESCRIPTION OF SYMBOLS 1 Package 2 Packaging material 21 Seal part 22 Partition part 23, 24 Weak seal part 25 Partition part 26, 27 Weak seal part 28, 29 Partition part 3 Zipper 4 1st space 5 2nd space 6 3rd space 7 Catheter 8 Deodorant 81 Container 9 Antibacterial sheet 10 Fluid substance 11 Small packaging material 12 Water-absorbing material 13 Sealing member 131 Short tube 132 Cylindrical body 133 Solid columnar part 134 Breaking part 135 Upper end part 136 Reduced diameter part 14 Small packaging material

 ──────────────────────────────────────────────────続 き Continuation of front page (72) Inventor Masaomi Imai 2-44-1, Hatagaya, Shibuya-ku, Tokyo Terumo Corporation F-term (reference) 3E067 AA03 AA11 AB83 AB96 AB97 AC06 BB12A BB14A BB15A BB16A BB25A CA05 CA09 CA24 EA06 EA25 EB17 EE21 GB15 GC05 GD08

Claims (15)

[Claims] 1. A packaging material having a first space and a second space which are separated from each other by a partition portion and can communicate with each other when necessary. The packaging material is housed in the first space and inserted or attached to a living body for use. A device that is contained in the first space and eliminates or reduces odor; and a fluidity that is contained in the second space and is capable of contacting the surface of the device and reducing its frictional resistance. And a substance. 2. The package according to claim 1, wherein a main component of the substance that extinguishes or reduces the odor is titanium oxide. 3. A packaging material having a first space and a second space which are separated from each other by a partition portion and can communicate with each other when necessary, and which is stored in the first space and inserted or attached to a living body for use. A device that is stored in the first space and has a function of suppressing at least the growth of microorganisms; and a device that is stored in the second space and contacts the surface of the device to reduce its frictional resistance. And a flowable substance. 4. The package according to claim 3, wherein a main component of the substance having a function of suppressing the growth of microorganisms is titanium oxide. 5. A packaging material having a first space, a second space, and a third space which are separated from each other by a partition portion and can be communicated when necessary, and a packaging material which is housed in the first space and inserted into a living body or A device that is mounted and used; a fluid material that is stored in the second space and that can contact the surface of the device and reduce its frictional resistance; and a fluid that is stored in the third space and Characterized by comprising a substance capable of absorbing and retaining the compound. 6. A packaging material having a first space, a second space, and a third space which are separated from each other by a partition portion and can communicate when necessary, and a packaging material which is housed in the first space and inserted into a living body or A package comprising: a device to be mounted and used; a blood anticoagulant stored in the second space; and a substance stored in the third space and capable of absorbing and holding a liquid. body. 7. The device according to claim 5, wherein the first space and the second space are formed adjacent to each other, and the first space and the third space are formed adjacent to each other. 7. The package according to 6. 8. The package according to claim 1, wherein the second space is formed inside the first space. 9. The partition section is formed of a sealing section formed by fusing sheet materials constituting the packaging material.
9. The package according to any one of items 1 to 8. 10. The package according to claim 1, wherein at least a part of the partition part is formed by a weak seal part having a lower joining strength than other parts. 11. The apparatus according to claim 1, further comprising: an opening for removing the device from the first space; and sealing means for sealing the opening after opening the opening. The package as described. 12. The package according to claim 1, wherein the packaging material has a steam barrier property. 13. The package according to claim 1, wherein the device is a catheter or a guide wire. 14. The package according to claim 1, wherein the device is a catheter used by being inserted into the urethra. 15. On at least a part of the surface of the device,
The package according to any one of claims 1 to 14, further comprising a compound exhibiting lubricity when wetted.