JP2000044481A - Preparation for external use for skin - Google Patents

Abstract

PROBLEM TO BE SOLVED: To obtain a preparation for external use for skin having excellent inflammation inhibitory activity and itch inhibitory activity by formulating a combination of each specific plant extract. SOLUTION: This preparation for external use for skin contains a combination of at least one kind of extract derived from plant(s) selected from Sophora angustifolia, lmpatience balsamina L. and peppermint with at least another kind of extract derived from plant(s) selected from Artemisia princeps, Ligusticum acutilobum, Sanguisorba officinalis, root of Glycyrrhiza glabra, Aloe, Luffa cylindrica, root of Scutellaria baicalensis, sea algae, Matricaria chamomilla, Cape jasmine, Sasa albo-marginata, Morus alba, Perilla frutescens crispa, Betula tauschii, Equisetum arvense, Achillea milefolium, carrot, Hamamelis virginiana L., rose, Aesculus hippocastanum, Ganoderma lucidum, Calendula officinalis, rosemary, apple, Hedera helix, Coix lachrymajobi, peach, Prunus armeniaca, Paeonia lactiflora, rhizome of Zingiber officinale, Kochia scoparia, and peony.

Description

DETAILED DESCRIPTION OF THE INVENTION

[0001]

TECHNICAL FIELD The present invention relates to an external preparation for skin having an excellent inflammation-suppressing action and an itching-inhibiting action when combined with extracts of specific plants.

[0002]

2. Description of the Related Art In recent years, skin diseases such as atopic dermatitis and senile pruritus have been regarded as problems, and the number of patients has been increasing year by year. These skin diseases are known as itch-related diseases, but itching causes mental discomfort to the patient and worsens the symptoms by scratching.
In order to prevent or treat these skin diseases, various external preparations have been proposed. For example, corticosteroids are excellent anti-inflammatory agents and have excellent anti-inflammatory effects on diseases,
Although it has an itching-suppressing effect, there are concerns about side effects, and it is hard to say that it is a satisfactory therapeutic agent. It is also considered to use a plant extract as a substance having a mild effect on the skin, and it has been proposed to suppress itching and inflammation.

[0003]

Means for Solving the Problems The present inventors diligently studied a naturally occurring drug which is effective in suppressing itch and inflammation.
That is, histamine is well known as an itch-inducing substance, and histamine is released into tissues by degranulation of mast cells, causing itch, which is an initial reaction in which inflammation occurs. Has a histamine release inhibitory effect (in vitro) on various plant extracts.
o) and an anti-inflammatory effect (in vivo) against an inflammatory agent (compound 48/80) were searched for as an index. By using an extract of a specific plant in combination, a more excellent anti-inflammatory and anti-itch effect was obtained. They have found out that they have achieved this, and have completed the present invention.

[0004]

DESCRIPTION OF THE PREFERRED EMBODIMENTS That is, the present invention relates to an extract of at least one selected from Clara, Balsam, and mint, as well as mugwort, toki, waremokou, licorice, aloe, luffa, giant gourd, seaweed, chamomile and gardenia. , Kumazasa, Mulberry, Perilla, Birch, Horsetail, Caribbean, Hawberry, Rose, Marronnier, Mannentake, Toukisenka, Rosemary, Apple, Atlantic Owl, Barley, Peach, Apricot, Peony,
The present invention relates to an external preparation for skin, which exhibits an excellent inflammation-suppressing action and itching-suppressing action, characterized in that it is used in combination with at least one or more extracted extracts selected from ginger, pufferfish and buttonpicks.

[0005] The plant used in the present invention may be whole plant or a preferable part. For example, Clara has roots, Balsam has flowers, mint has leaves, mugworts have leaves, Toki has roots, Warm Mocks has roots, Licorice has roots,
Aloe for leaves, loofah for above-ground parts, ogre for roots, chamomile for flowers, gardenia for fruits, Kumazasa for leaves, mulberry for roots, perilla for leaves, birch for bark, carrots for roots. , Hamamelis leaves, roots, bark, roses, flowers, ginseng, fruit bodies, rosemary, flowers, rosemary, leaves or flowers, apples, fruits, adlay seeds, peaches, seeds or fruits. Or leaves, apricots use seeds, peonies use roots, and ginger use roots. Extracts extracted from these plants can be obtained by the following method. For example, a raw or dried plant is extracted with water or an aqueous organic solvent. Usually, it is preferable that the extraction solvent is added 2 to 5 times the volume of the raw material and the extraction is repeated 2 to 3 times. Although extraction can be sufficiently performed with water, an aqueous organic solvent may be used to prevent decay of the extract and to promote extraction. Examples of the aqueous organic solvent include lower alcohols such as methanol and ethanol. This extraction is promoted by heating, and the raw material is preferably crushed or pulverized. It should be noted that there is no problem if these components are incorporated into the cosmetics as they are, but they may be treated with activated carbon or the like for the purpose of decolorization or deodorization as required.

[0006] The external preparation for skin combined with the specific plant extract thus obtained has an excellent anti-inflammatory and anti-itch effect as described later, and also has an excellent effect of preventing and improving rough skin. It turned out to be. These effects are 0.0
It is remarkably observed when it is blended in the range of 01 to 20% by weight, and preferably when both extracts are blended in the amount of 0.1 to 10% by weight.

[0007] The external preparation for skin of the present invention has an anti-inflammatory effect commonly used in cosmetics, quasi-drugs, pharmaceuticals, etc., in addition to the plant extract, if necessary, as long as the effects of the present invention are not impaired. Ingredients, for example, oxybenzone, tranexamic acid, and derivatives thereof, allantoin, epsilon aminocaproic acid, glycyrrhizic acid, Photosensitizer No. 301, 40
No. 1, one or two or more of diphenhydramine hydrochloride, adenosine acid, calamine, water-soluble azulene, aminocaproic acid, salicylic acid, and bisapolol extract may be blended.

The external preparation of the present invention may further contain, in addition to the above-mentioned active ingredients, if necessary, components generally used in cosmetics, quasi-drugs, pharmaceuticals, etc. as long as the effects of the present invention are not impaired. Activators, humectants such as glycerin, 1,3-butylene glycol, hyaluronic acid, ceramide, ultraviolet absorbers and ultraviolet scattering agents, thickeners, preservatives, antioxidants, fragrances,
A coloring agent or the like can be blended. The agent system of the external preparation of the present invention is arbitrary, and for example, it can be prepared in an agent system such as an aqueous solution system, a solubilizing system, an emulsifying system, a powder system, an oil liquid system, a gel system and an ointment system.

[0009]

EXAMPLES The effects of the present invention will be described below with reference to experimental examples. EXPERIMENTAL EXAMPLE 1 <Preparation of Extract> 400 g of dried plant material was added to 50% (V
/ V) After immersion in 5 liters of an aqueous ethanol solution, extraction was performed by heating under reflux for 2 hours. Then the same amount of ethanol:
After similarly extracting with heating and refluxing for 2 hours using a water mixture, the extracts were combined by filtration, and then evaporated to dryness under reduced pressure to obtain a brown powdery substance.

<Histamine release inhibition test> Male rats (W
ister / ST system, weight about 150g), 0.1% intraperitoneally
BSA phosphate buffer was injected, mast cells were collected according to a conventional method, and a cell suspension was prepared. 25 μg / ml (final concentration) or 50 μg / m
l (final concentration), or a combination of the above extracts in the range of 5 μg / ml to 25 μg / ml (final concentration).
10 minutes after the addition of the extracted extract,
d48 / 80) was added, and the amount of free and intracellular histamine for 10 minutes was quantified by a fluorescence method, and the release inhibition rate (%) was calculated according to the formula shown in Equation 1. Table 1 shows the results.

[0011]

(Equation 1)

[0012]

[Table 1]

[0013] As shown in Table 1, balsam, mint,
At least one or more extracted extracts selected from Clara, mugwort, toki, waremokou, licorice, aloe, luffa, ougon, seaweed, chamomile, gardenia, kumazasa,
At least one selected from mulberry, perilla, birch, horsetail, Achillea millefolium, carrot, hamamelis, rose, marronnier, mannenthus mushroom, cornflower, rosemary, apple, prunus omelette, barley, peach, apricot, peonies, gingerbread, squirrel, buttonpipi
It can be seen that when more than one kind of extract is used in combination, histamine release is synergistically suppressed as compared with the case where the same amount of extract is used alone.

<Paw edema inhibition test> 2.5% by weight or 5.0% by weight of the above-mentioned extract or 2.5% by weight of each extract
The extract mixed by weight% was mixed into macrogol ointment, which was applied to the right hind paw of a male rat (Wister / ST system, body weight: about 150 g). Compound48 / dissolved in physiological saline
80 was injected subcutaneously. Thirty minutes later, the swelling volume was measured by a foot volume measuring device, the edema rate was calculated according to the equation shown in Equation 2, and the edema rate was compared with the edema rate in a control group to which Macrogol ointment containing no extract was applied. The suppression rate was calculated according to the formula shown in FIG. Table 2 shows the results.

[0015]

(Equation 2)

[0016]

(Equation 3)

[0017]

[Table 2]

As shown in Table 2, the balsam, mint,
At least one or more extracted extracts selected from Clara, mugwort, toki, waremokou, licorice, aloe, luffa, ougon, seaweed, chamomile, gardenia, kumazasa,
At least one selected from mulberry, perilla, birch, horsetail, Achillea millefolium, carrot, hamamelis, rose, marronnier, mannentake, toukisenka, rosemary, apple, prunus sylvestris, barley, peach, apricot, peonies, gingerbread, squirrel, buttonpipi
It can be seen that when more than one kind of extract is used in combination, paw edema is synergistically suppressed as compared with the case where the same amount of extract is used alone. Furthermore, it was also confirmed that when the ointment of Example 1 was applied to the skin of a person having rough skin, there was an effect of improving the rough skin.

Example 27: Ointment Ingredients Compounding amount (% by weight) Artemisia extract 2.5 Clara extract 2.5 Propylene glycol # 400 15.0 Macrogol ointment 80.0 The artemisia extract and Clara extract obtained in Experimental example 1 are uniformly dispersed in propylene glycol # 400. After that, macrogol ointment is added and mixed.

Example 28: Ointment Ingredients Compounding amount (% by weight) Rose extract 1.5 Artemisia extract 1.0 Balsam extract 2.5 Propylene glycol # 400 15.0 Macrogol ointment 80.0 The rose extract, artemisia extract and artemisia extract obtained in Experimental Example 1 were converted to propylene glycol # 400. And then add Macrogol ointment and mix.

Example 29: Lotion lotion component content (% by weight) mugwort extract 1.0 seaweed extract 1.0 mannentake extract 1.0 mint extract 1.0 clara extract 1.0 glycerin 6.0 ethanol 9.0 polyoxyethylene hydrogenated castor oil 0.8 methyl paraben 0.05 citric acid 0.05 sodium citrate 0.07 Fragrance 0.1 Purified water Remainder Total 100.0 Glycerin, citric acid, sodium citrate,
The mugwort extract, seaweed extract, ginseng extract, mint extract and Clara extract obtained in Experimental Example 1 are dissolved. Polyoxyethylene hydrogenated castor oil (60.EO), methyl paraben, and fragrance were individually dissolved in ethanol, added to the above aqueous solution, solubilized, and filtered to obtain a lotion.

Example 30: Lotion Component Ingredients Amount (wt%) Peony Extract 1.0 Apple Extract 1.0 Mannentake Extract 1.0 Clara Extract 1.0 Datura Extract 1.0 Glycerin 6.0 Ethanol 9.0 Polyoxyethylene Hardened Castor Oil 0.8 Methylparaben 0.05 Citric Acid 0.05 Sodium Citrate 0.07 Fragrance 0.1 Purified water Remainder Total 100.0 Glycerin, citric acid, sodium citrate,
The peony extract, the apple extract, the Ganoderma lucidum extract, the Clara extract and the balsam pear extract obtained in Experimental Example 1 are dissolved. Polyoxyethylene hydrogenated castor oil (60.EO), methyl paraben,
The fragrance was dissolved, added to the aqueous solution to solubilize, and filtered to obtain a lotion.

Example 31: Cream Ingredients Compounding amount (% by weight) Ingredient (A) Polyglycerin fatty acid ester 4.0 Cetanol 2.0 Stearic acid 1.0 Isopropyl myristate 5.0 Olive oil 2.0 Squalane 9.0 Self-emulsifying glyceryl monostearate 3.0 Paraben 0.3 Ingredient (B Peach extract 0.5 Aloe extract 0.5 Clara extract 0.5 Mint extract 0.5 Glycerin 5.0 Trimethylglycine 1.0 Fragrance 0.2 Purified water Remaining component (C) Potassium hydroxide aqueous solution 3.0 (prepared to 100% with purified water) Heat and dissolve component (A), Bring to 80 ° C. Separately, the component (B) excluding the fragrance is dissolved by heating and kept at 80 ° C., and the component (A) is added thereto with stirring and mixed well. Further, the component (C) was added, the mixture was cooled with stirring, a flavor was added, and the mixture was further mixed to obtain a cream.

Example 32: Cream Ingredients Compounding amount (% by weight) Ingredient (A) Polyglycerin fatty acid ester 4.0 Cetanol 2.0 Stearic acid 1.0 Isopropyl myristate 5.0 Olive oil 2.0 Squalane 9.0 Self-emulsifying glyceryl monostearate 3.0 Paraben 0.3 Ingredient (B ) Barley extract 0.5 Birch extract 0.5 Japanese gourd extract 0.5 Balsam pear extract 0.5 Mint extract 0.5 Glycerin 5.0 Trimethylglycine 1.0 Perfume 0.2 Purified water Remaining component (C) Potassium hydroxide aqueous solution 3.0 (prepared to 100% with purified water) Component (A) Heat and melt to 80 ° C. Separately, the component (B) excluding the fragrance is dissolved by heating and kept at 80 ° C., and the component (A) is added thereto with stirring and mixed well. Further, the component (C) was added, the mixture was cooled with stirring, a flavor was added, and the mixture was further mixed to obtain a cream.

[0025]

The external preparation for skin obtained by the present invention has an excellent anti-inflammatory and anti-itch effect, and skin symptoms accompanied by inflammation and inflammation such as atopic dermatitis and senile pruritus. To alleviate and improve the effect. Furthermore, the obtained external preparation for skin was effective for excellent skin roughness improvement.

──────────────────────────────────────────────────続 き Continued on the front page (51) Int.Cl. ⁷ Identification symbol FI theme coat ゛ (reference) // A61K 9/06 A61K 9/06 GF term (reference) 4C076 AA08 AA12 BB31 CC18 DD37E DD38E DD38F DD43E EE23 EE23A EE54 EE54A EE54E EE58A FF15 FF16 4C083 AA031 AA032 AA111 AA112 AA122 AC022 AC072 AC102 AC122 AC242 AC302 AC352 AC422 AC432 AC482 AC582 AD042 CC03 CC04 CC05 DD22 DD23 DD27 DD31 EE11 EE13 4C088 AA18 AB18A AB18 AB AB51 AB52 AB58 AB59 AB60 AB76 AB77 AB81 AB86 AC01 AC02 AC03 AC04 AC05 AC06 AC11 AC13 AC17 BA04 BA05 BA09 BA10 MA07 MA63 NA14 ZA89 ZB11 ZC13

Claims (1)

[Claims] Claims: 1. An extract of at least one selected from Clara, Balsam, and Mint, Artemisia, Toki, Warmoko, Licorice, Aloe, Loofah, Ogon, Seaweed, Chamomile, Gardenia, Kumazasa, Mulberry, Perilla, Birch , Horse chestnut, Achillea millefolium, carrot, hamamelis, rose, marronnier, mannentake, toukisenka, rosemary, apple, pear sword, adlay, peach, apricot, peonies, gingerbread, pear, peanut, buttonpipi and at least one or more extracted extracts An external preparation for skin, characterized by comprising: